using new data source https://howbad.info/essd.zip

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1.json

@@ -1 +1 @@
-{"Constipation ": 17.649962607021507, "Dyspnoea ": 3.549147030514927, "Flatulence ": 77.6903463799255, "Oropharyngeal pain ": 23.775160354588635, "Stevens-Johnson syndrome ": 67.16782399335501, "Toxic epidermal necrolysis ": 102.8388320701753}
+{"Constipation": 17.649962607021507, "Dyspnoea": 3.5490943061549447, "Flatulence": 77.68403086713583, "Oropharyngeal pain": 23.775160354588635, "Stevens-Johnson syndrome": 67.16782399335501, "Toxic epidermal necrolysis": 102.8388320701753}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/10.json

@@ -1 +1 @@
-{"Anaemia ": 3.221139019553731, "Ascites ": 10.14915246132696, "Bone disorder ": 10.893484085997594, "Breast cancer ": 12.773341168622522, "Breast cancer metastatic ": 138.3994817997619, "Burning sensation ": 2.8588241058322024, "Cellulitis ": 2.494823195421424, "Cholangitis ": 15.685979048365702, "Colitis ": 3.2960868771241767, "Cytogenetic analysis abnormal ": 137.05939990758466, "Dehydration ": 2.809936588812284, "Disease progression ": 5.21830205447912, "Drug-induced liver injury ": 2.0043875657427934, "Dyspnoea exertional ": 3.8190710535249415, "Enterocolitis ": 11.859604200114305, "Febrile neutropenia ": 11.1327560184904, "Gene mutation ": 91.3961623391678, "Hepatic lesion ": 55.30702437836333, "Hypophagia ": 23.78003164441682, "Hypoxia ": 2.816162523260792, "Immune-mediated enterocolitis ": 17.59032851999298, "Interstitial lung disease ": 10.92154847537796, "Joint stiffness ": 8.050645948755175, "Liver disorder ": 2.642989716356119, "Malignant neoplasm progression ": 23.199986162423457, "Metastases to bone ": 67.35189139787303, "Metastases to central nervous system ": 13.197444504172031, "Metastases to liver ": 33.89317051002639, "Metastases to lung ": 27.63412771485676, "Metastases to pelvis ": 264.92328007524685, "Metastases to peritoneum ": 49.41912303055205, "Metastases to skin ": 81.71431836821557, "Metastasis ": 30.71685088447018, "Mouth ulceration ": 9.370436500008594, "Mucosal inflammation ": 4.013792314933522, "Myelosuppression ": 5.778864293248316, "Nail avulsion ": 1241.19955539701, "Neoplasm progression ": 12.139220611551323, "Neuropathy peripheral ": 8.785271456498513, "Neutropenia ": 3.59197947071274, "Neutrophil count decreased ": 3.848992886754123, "PIK3CA-activated mutation ": 384.2762242630757, "Palmar-plantar erythrodysaesthesia syndrome ": 3.692960490420063, "Pancreatic carcinoma ": 3.9089567940666585, "Pancreatic carcinoma metastatic ": 22.55899605603173, "Peripheral sensory neuropathy ": 14.671557522902848, "Pleural effusion ": 8.437691917801445, "Pneumonitis ": 10.89664039951243, "Pulmonary mass ": 23.2670822950978, "Skin disorder ": 2.1930768722299785, "Spinal compression fracture ": 11.192615021638726, "Staphylococcal infection ": 5.857026410008794, "Stomatitis ": 5.317968489156255, "Thrombocytopenia ": 2.46024335371934, "Tumour marker increased ": 50.55661377691028, "White blood cell count decreased ": 2.5571074605085102}
+{"Emotional distress": 161.85208465362794, "Hypersensitivity": 70.04082379006084, "Injury": 405.2825412437928}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1001.json

@@ -1 +1 @@
-{"Intentional overdose ": 36.05160301566608}
+{"Blood creatinine increased": 10.554728842142492, "Kidney transplant rejection": 453.1409148085539}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1002.json

@@ -1 +1 @@
-{"Alpha 1 foetoprotein increased ": 117.58745308698218, "Ascites ": 5.550053398271658, "Blister ": 3.4120996548188627, "Diarrhoea ": 3.340768320133641, "Disease progression ": 5.839117538334553, "Drug ineffective for unapproved indication ": 6.258355117317848, "Erythema multiforme ": 5.510979238909851, "Haematotoxicity ": 11.741519357162655, "Hepatic encephalopathy ": 10.293247755647284, "Hepatic failure ": 6.0591430036270655, "Hepatocellular carcinoma ": 45.14421136202953, "Hepatotoxicity ": 5.478867204588851, "Hyperkeratosis ": 18.3733643542266, "Hypertension ": 3.0134384879071807, "Hypocalcaemia ": 9.6470695970997, "International normalised ratio increased ": 2.1038195462158686, "Malignant neoplasm progression ": 2.809789132493224, "Metastases to adrenals ": 69.905760963194, "Metastases to bone ": 8.459648334480317, "Metastases to liver ": 6.502514645388471, "Metastases to lung ": 30.543054872294285, "Metastatic renal cell carcinoma ": 30.86796027671447, "Mucosal inflammation ": 8.28979992726653, "Neoplasm progression ": 3.452534897166229, "Off label use ": 5.294186295744967, "Osteonecrosis of jaw ": 14.70981260897226, "Palmar-plantar erythrodysaesthesia syndrome ": 71.92652538146406, "Product use in unapproved indication ": 7.835608085660607, "Rash maculo-papular ": 2.776626436271433, "Renal cell carcinoma ": 15.910019249109528, "Skin exfoliation ": 2.8192660283382813, "Skin reaction ": 4.758319618050393, "Skin toxicity ": 49.06436858647975, "Skin ulcer ": 6.50701368486814, "Squamous cell carcinoma of skin ": 28.353003645537928, "Stevens-Johnson syndrome ": 4.156051349482739, "Thrombocytopenia ": 3.7812584689836473, "Tumour lysis syndrome ": 15.731632606322991, "Weight decreased ": 2.306152531961974}
+{"Acute kidney injury": 3.534002050770199, "Angioedema": 7.539282653142957, "Drug ineffective for unapproved indication": 20.73629511858232, "Drug interaction": 16.028467435603925, "Liver transplant rejection": 340.61135450972023, "Off label use": 3.728950871336153, "Product use in unapproved indication": 8.56891060528179, "Transplant rejection": 68.93462089310147}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1003.json

@@ -1 +1 @@
-{"Alanine aminotransferase increased ": 10.805313105473848, "Aspartate aminotransferase increased ": 9.902324177422711, "Blood bilirubin increased ": 9.164748462552684, "Diarrhoea ": 5.963991070516686, "Disease progression ": 10.689063711986478, "Drug-induced liver injury ": 10.625814518937682, "Hepatic enzyme increased ": 5.34836961827246, "Hepatic function abnormal ": 9.268010685628123, "Hepatotoxicity ": 44.974335675532025, "Liver disorder ": 6.937692081216955, "Liver function test increased ": 17.2586945444678, "Lung adenocarcinoma ": 136.47393837646254, "Lung neoplasm malignant ": 12.518128619614066, "Non-small cell lung cancer ": 917.6710243441228, "Non-small cell lung cancer metastatic ": 2736.759079656651, "Off label use ": 2.092753891529357, "Therapy partial responder ": 73.56637711356981}
+{"Alanine aminotransferase increased": 4.805884049268032, "Anaemia": 3.8919569772032, "Aspartate aminotransferase increased": 4.228994240474632, "Blood potassium decreased": 18.92882110415466, "Death": 2.4279047452921247, "Drug-induced liver injury": 11.672797761891626, "Electrocardiogram QT prolonged": 112.0765038457217, "Haemoglobin decreased": 2.7795116537951228, "Hepatic function abnormal": 4.097208895425196, "Hypokalaemia": 3.030467415493918, "Intentional product use issue": 20.168822450481315, "Liver injury": 12.052242875590746, "Neuropathy peripheral": 7.837996165019741, "Off label use": 5.954478088971817, "Product use issue": 5.170778410045484, "Pulmonary tuberculosis": 70.57367086101097, "Rash pruritic": 3.546455720479756, "Respiratory failure": 11.78429460621224}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1004.json

@@ -1 +1 @@
-{"Altered state of consciousness ": 2.024050394367631, "Ammonia increased ": 7.394131877404162, "Anaemia ": 8.55958588248953, "Ascites ": 9.094616982559542, "Atrial septal defect ": 6.304609474381127, "Autoimmune hepatitis ": 4.34647692809549, "Blood bilirubin increased ": 7.412695506256812, "Cerebral haemorrhage ": 2.4261612946622457, "Cerebral infarction ": 3.809744463535769, "Colitis ischaemic ": 5.542067546483547, "Death ": 2.0131114079317567, "Depression ": 2.201360839632474, "Disseminated intravascular coagulation ": 2.2543983797041407, "Drug ineffective ": 9.329143511706736, "Genotype drug resistance test positive ": 15.422815593871432, "Glomerular filtration rate decreased ": 4.504709760160125, "Haematemesis ": 3.071148194505439, "Haemoglobin decreased ": 8.082692589051026, "Haemolytic anaemia ": 12.313385417004216, "Hepatic cancer ": 14.629033122198743, "Hepatic cancer recurrent ": 602.0039890255414, "Hepatic cirrhosis ": 22.786745654044303, "Hepatic encephalopathy ": 28.74600624895768, "Hepatic failure ": 5.931417114939051, "Hepatic fibrosis ": 12.041285487330828, "Hepatitis ": 3.55365924842276, "Hepatitis B reactivation ": 24.750836315201404, "Hepatitis C ": 140.67988130454347, "Hepatitis C RNA increased ": 76.9606002229754, "Hepatitis C RNA positive ": 259.072465501785, "Hepatitis C virus test positive ": 55.05430937726681, "Hepatocellular carcinoma ": 48.2368636220552, "Hepatorenal syndrome ": 16.059846038349804, "Hyperbilirubinaemia ": 19.273544181611605, "Incorrect product administration duration ": 6.3377282494176175, "Infection reactivation ": 75.01193638089899, "Jaundice ": 7.378857502671108, "Loss of consciousness ": 2.441487455317065, "Lung neoplasm malignant ": 2.0633085005915626, "Lymphoma ": 6.231909913666382, "Mood swings ": 2.400183233757752, "Multiple organ dysfunction syndrome ": 2.8095887428918456, "Neoplasm malignant ": 2.3829166882263846, "Oedema peripheral ": 2.315672842128636, "Oesophageal varices haemorrhage ": 38.12947358924573, "Pancreatitis acute ": 2.857094945402418, "Photosensitivity reaction ": 2.332324622538988, "Portal vein thrombosis ": 15.421635932283817, "Product complaint ": 2.159330908377829, "Renal impairment ": 4.034343000103323, "Septic shock ": 3.187501681052547, "Spontaneous bacterial peritonitis ": 47.82313725936973, "Treatment failure ": 15.409961112093988, "Treatment noncompliance ": 3.1921722220004702, "Unevaluable event ": 2.45048167784442, "Upper gastrointestinal haemorrhage ": 2.09455964634024, "Viral load increased ": 23.913711484866848, "Virologic failure ": 24.4060372416836}
+{"Acute kidney injury": 2.587392476279438, "Angioedema": 3.835539714065976, "Atrial fibrillation": 3.154099036720609, "Blood glucose increased": 2.143764055540013, "Completed suicide": 19.66567288460777, "Diabetes mellitus": 7.759073765927343, "Diabetes mellitus inadequate control": 24.894974495762845, "Drug interaction": 3.1260122672941804, "Hyperkalaemia": 6.013446941180351, "Hypoglycaemia": 13.789757839468932, "Infusion site extravasation": 175.88972800076286, "Lactic acidosis": 21.52830886033204, "Loss of consciousness": 2.3881972117019874, "Pemphigoid": 36.49822139696445, "Product monitoring error": 290.8439585151044, "Toxicity to various agents": 5.338830471858231, "Tremor": 2.0420126053534013, "Wrong patient received product": 94.19399297381086}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1005.json

@@ -1 +1 @@
-{"Pancreatitis acute ": 73.61796610087383}
+{}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1008.json

@@ -1 +1 @@
-{"Acute generalised exanthematous pustulosis ": 11.07671652950718, "Acute kidney injury ": 8.422207320297622, "Aortic valve incompetence ": 11.268573145889905, "Ascites ": 2.1136240177036707, "Asthenia ": 3.9685167624373614, "Atrial fibrillation ": 2.971471402157264, "Atrioventricular block first degree ": 35.292927625036306, "Blood bicarbonate decreased ": 18.995486497641668, "Blood creatinine increased ": 4.861131845862096, "Blood potassium decreased ": 6.039902749214058, "Blood potassium increased ": 16.094187136185464, "Blood urea increased ": 7.348090767427529, "Bradycardia ": 4.588331015162281, "Bradykinesia ": 10.966886660036874, "Bundle branch block left ": 23.01533555110131, "Cardiac amyloidosis ": 112.6449002631122, "Cardiac failure ": 3.636681709964913, "Cardiac failure acute ": 7.21211825262986, "Cardiac failure chronic ": 15.220407114938345, "Cardioactive drug level increased ": 11.764740399343404, "Cardiomegaly ": 4.053404230326045, "Coagulopathy ": 4.447403936477113, "Cognitive disorder ": 3.055447068404584, "Coronary artery disease ": 2.121879978125937, "Dehydration ": 4.63280570699531, "Dementia ": 5.34560661643054, "Drug interaction ": 3.2508871332603007, "Drug reaction with eosinophilia and systemic symptoms ": 6.40340977636457, "Dyspnoea at rest ": 14.069321519260678, "Dysuria ": 3.1585164248025936, "Electrocardiogram QRS complex prolonged ": 22.613720660769097, "Electrocardiogram QT prolonged ": 2.033134358926629, "Electrocardiogram T wave peaked ": 125.96764329885842, "Electrocardiogram abnormal ": 6.0407738948376, "Electrolyte imbalance ": 4.82379326386435, "Exercise tolerance decreased ": 3.2848676507240726, "Fall ": 2.822373179836537, "Fluid retention ": 2.71226278834474, "Gastric polyps ": 23.037116044823573, "Glomerular filtration rate decreased ": 3.442983425662264, "Gynaecomastia ": 15.522617916415909, "Haematuria ": 2.502485500229438, "Heart failure with reduced ejection fraction ": 91.6620794935685, "Hiatus hernia ": 9.265685885806302, "Hyperkalaemia ": 53.296380247026285, "Hypokalaemia ": 4.438349673040297, "Hyponatraemia ": 10.753680909294111, "Hypophagia ": 4.001368138956946, "Hypotension ": 5.585144448530038, "Hypovolaemia ": 15.800302349654713, "Left ventricular dysfunction ": 7.442164055802391, "Medication error ": 3.736153846002881, "Metabolic acidosis ": 8.104403705802996, "Mitral valve incompetence ": 6.882078331051297, "Mobility decreased ": 2.240356063463286, "Motor dysfunction ": 9.763492882981032, "Multiple organ dysfunction syndrome ": 2.989912938021328, "Muscular weakness ": 2.534329561959896, "Neuroglycopenia ": 249.3962780602105, "Obstructive pancreatitis ": 53.42267375952956, "Oedema peripheral ": 3.818025650372767, "Oliguria ": 5.320506039465583, "Orthostatic hypotension ": 11.7506807097621, "Parkinsonism ": 9.596792245219186, "Premature delivery ": 3.490646309951432, "Product prescribing error ": 2.582734282324931, "Pulmonary congestion ": 5.505601221742188, "Pulmonary oedema ": 2.293647973691361, "Rales ": 6.71961083711728, "Renal impairment ": 2.7059326491478504, "Sedation ": 2.2512968587409645, "Sinus bradycardia ": 9.203078730037015, "Stevens-Johnson syndrome ": 12.230220316617617, "Tachypnoea ": 2.356091645541289, "Toxic epidermal necrolysis ": 2.25807257142071, "Transplant dysfunction ": 57.08350101015496, "Type 2 diabetes mellitus ": 2.373816391411525, "Urine output decreased ": 5.19943416198889, "Ventricular extrasystoles ": 3.746539828197271, "Ventricular tachycardia ": 5.605748626842942}
+{"Aggression": 75.87874501894635, "Agitation": 33.4324342605909, "Irritability": 30.746272970693337, "Middle insomnia": 108.16237748116951, "Product administered to patient of inappropriate age": 129.40971429495238, "Somnolence": 3.3420154094123924}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1009.json

@@ -1 +1 @@
-{"Acne ": 2.8943809398626428, "Acute febrile neutrophilic dermatosis ": 6.634634804836901, "Acute lymphocytic leukaemia recurrent ": 16.003557433818624, "Acute pulmonary oedema ": 4.703200832599902, "Adverse event ": 11.495086735934722, "Anaemia ": 2.384579389336615, "Ascites ": 2.692870506318313, "Aspiration pleural cavity ": 197.14187567627616, "Atrial fibrillation ": 2.229927328934941, "Back disorder ": 2.2719091286628488, "Blast cell crisis ": 109.22375482219668, "Blast cell proliferation ": 220.94495881242807, "Blast crisis in myelogenous leukaemia ": 48.87093153735267, "Blood disorder ": 5.0115704348312615, "Bone marrow disorder ": 24.01807590942227, "Bone marrow failure ": 4.066230714832817, "Bone marrow transplant ": 57.5797450471399, "Bone pain ": 2.4044314156253144, "Cardiac disorder ": 2.8237789212132216, "Cardiac failure ": 4.0948822638290805, "Cardiac failure congestive ": 4.369320382554774, "Cardiomegaly ": 2.342140589692949, "Cellulitis ": 2.11163914374498, "Chronic myeloid leukaemia ": 31.67543986635461, "Chronic myeloid leukaemia recurrent ": 67.695276543408, "Chronic myeloid leukaemia transformation ": 63.33824132155883, "Chylothorax ": 246.4346928007508, "Clostridium difficile infection ": 2.302652651206349, "Colitis ": 5.147579309064161, "Cytomegalovirus colitis ": 7.747378279755652, "Cytomegalovirus enterocolitis ": 20.096597514153, "Cytopenia ": 14.195674988659032, "Death ": 3.0955379074819898, "Dialysis ": 2.0407428764158344, "Drug resistance ": 2.3768187423880542, "Dyspnoea exertional ": 2.163196769848902, "Electrocardiogram QT prolonged ": 3.005192238850612, "Enterocolitis ": 4.007591691421756, "Enterocolitis haemorrhagic ": 17.94287258450815, "Eye haemorrhage ": 2.001490514118895, "Fluid retention ": 13.009506275855774, "Full blood count decreased ": 12.560052394155456, "Gallbladder disorder ": 2.766935122549561, "Gastrointestinal haemorrhage ": 3.3973685983653867, "Gastrointestinal infection ": 3.700380359652028, "Gene mutation ": 30.13713785139111, "Generalised oedema ": 3.022556364643147, "Graft versus host disease ": 4.342558962680672, "Haematochezia ": 2.25613447702314, "Haematotoxicity ": 4.18291779009479, "Haemorrhage ": 2.173939979543705, "Haemothorax ": 9.280297829664793, "Hospitalisation ": 12.146825424779822, "Intentional product use issue ": 4.0174721438645, "Internal haemorrhage ": 4.193435703955299, "Intestinal haemorrhage ": 2.6777595367461493, "Iron deficiency anaemia ": 2.633098621141812, "Leukaemia ": 9.611546395556612, "Leukaemia recurrent ": 11.621405669090858, "Lower gastrointestinal haemorrhage ": 3.111106895934293, "Lung disorder ": 2.0766461174880537, "Lung infiltration ": 4.648382745863988, "Lymphocytosis ": 10.32387784063538, "Malignant neoplasm progression ": 11.37571149675828, "Nephrotic syndrome ": 4.129193005343136, "Neuropathy peripheral ": 2.753664306520925, "Oedema ": 2.8288642460091658, "Pancytopenia ": 5.441121560058406, "Pericardial effusion ": 37.59568427821048, "Peripheral arterial occlusive disease ": 5.747034098392515, "Philadelphia chromosome positive ": 192.5274851188784, "Platelet count decreased ": 2.82738743825597, "Platelet count increased ": 3.0776449567349133, "Platelet transfusion ": 16.00890211337492, "Pleural effusion ": 109.2133794519122, "Pleurisy ": 14.555241378223528, "Pneumonia ": 3.621915036173572, "Pneumonia fungal ": 4.469600005136266, "Prescribed underdose ": 52.94852112096044, "Pulmonary alveolar haemorrhage ": 2.164208839156093, "Pulmonary arterial hypertension ": 29.84099635259896, "Pulmonary congestion ": 2.0745240644969254, "Pulmonary hypertension ": 36.73884058237484, "Pulmonary oedema ": 35.82384011054767, "Rectal cancer ": 5.159626074196619, "Red blood cell count decreased ": 3.0586655438707, "Respiratory tract congestion ": 3.683894496107481, "Retinal haemorrhage ": 2.576803306524529, "Right ventricular failure ": 3.663126823974151, "Splenomegaly ": 4.41534119793763, "Stem cell transplant ": 26.569155703680966, "Subdural haematoma ": 3.095648272598268, "Therapeutic response decreased ": 4.488711423594883, "Therapy non-responder ": 4.272067117253211, "Thrombocytopenia ": 3.4909548383879643, "Transfusion ": 8.59006720776718, "Transplant ": 8.928009173052821, "Tumour lysis syndrome ": 3.2651310485254226, "White blood cell count abnormal ": 3.2217981393792985, "White blood cell count increased ": 3.625381617941589}
+{"Ammonia increased": 85.14768935177429, "Cardiac arrest": 5.691845298571863, "Cerebrovascular insufficiency": 1687.92266617122, "Cluster headache": 93.0829645908044, "Coma": 7.077070081568211, "Confusional state": 4.934083684780522, "Drug abuse": 8.448666755634182, "Drug interaction": 14.412439204413706, "Drug level increased": 21.253946300848245, "Electroencephalogram abnormal": 87.68644476337025, "Eye movement disorder": 46.17764180242136, "Inhibitory drug interaction": 199.73286981245587, "Miosis": 51.29912456556964, "Multiple organ dysfunction syndrome": 10.636908014887943, "Myoclonus": 24.15322610955697, "Overdose": 17.66334240346588, "Somnolence": 3.1921201048783825, "Toxicity to various agents": 19.5116998130631}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1010.json

@@ -1 +1 @@
-{"Completed suicide ": 53.30328829485575, "Drug interaction ": 16.656255131491992}
+{"Anaemia": 2.415525757893432, "Ascites": 5.870984986841708, "Bradycardia": 8.356390750732139, "Death": 2.2323323476761026, "Drug ineffective": 5.700401037500559, "Drug interaction": 4.796295965875079, "Genotype drug resistance test positive": 117.6370637123594, "Hepatitis C": 72.37544742557667, "Hepatocellular carcinoma": 23.772727215694548, "Intentional dose omission": 99.27973837023455, "Product dose omission issue": 6.241568586349409, "Treatment failure": 27.035609476735512}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1012.json

@@ -1 +1 @@
-{"Abdominal pain ": 3.699398444925811, "Lactic acidosis ": 59.73239803503783, "Lipoatrophy ": 502.6771923047401, "Pancreatitis ": 11.936607486507832}
+{"Abscess limb": 27.31409671249371, "Acne": 3.2689167459726987, "Apnoea": 12.316305373243914, "Autoimmune thyroiditis": 14.285540665721554, "Blood alkaline phosphatase increased": 3.775187826782616, "Blood follicle stimulating hormone increased": 128.62945455890866, "Brain neoplasm": 32.95469153570535, "Cerebral infarction": 3.2111979663106425, "Condition aggravated": 2.159508749101408, "Contusion": 3.217902387412193, "Craniopharyngioma": 626.4802843396005, "Dehydration": 3.0904776507878875, "Diabetes mellitus": 5.843430255987122, "Disease recurrence": 10.460935280923849, "Drug abuse": 4.682739818575517, "Drug-induced liver injury": 10.747336530746834, "Eating disorder": 4.873289348430135, "Electrolyte imbalance": 9.670530122271732, "Enteritis": 18.699391002719537, "Epiphysiolysis": 722.4450930132522, "Fluid retention": 3.469666284043281, "Focal nodular hyperplasia": 148.3289695208738, "Focal segmental glomerulosclerosis": 77.75742512517103, "Gastrointestinal infection": 38.17183352978912, "Glucose tolerance impaired": 68.31341766630216, "Glycosylated haemoglobin increased": 3.522666981774041, "Head injury": 4.360510550601289, "Hepatic cirrhosis": 26.67277078647569, "Hepatic encephalopathy": 44.40357586596575, "Hepatic necrosis": 118.82859525466692, "Hepatomegaly": 11.912783809452428, "Hepatotoxicity": 13.493550296518764, "Hypoglycaemia": 2.576591646842401, "Hyponatraemic seizure": 386.1438015596223, "Hypophagia": 6.471100344467632, "Idiopathic intracranial hypertension": 241.6653602346964, "Increased appetite": 10.64671010133172, "Injection site atrophy": 88.83987535467666, "Injection site bruising": 10.547298936069764, "Injection site haemorrhage": 9.86754881187074, "Insulin resistance": 35.62490278094377, "Insulin-like growth factor increased": 278.57056558083264, "Intentional product misuse": 2.0170800566277776, "Intracranial pressure increased": 58.61924593764471, "Lower limb fracture": 9.307119250187409, "Meningioma": 56.60556288884906, "Myocardial fibrosis": 99.93713553370924, "Neoplasm recurrence": 93.530186464796, "Obstructive sleep apnoea syndrome": 93.44473712164935, "Oesophageal disorder": 49.96482074252936, "Off label use": 3.0642471280183825, "Pancreatitis acute": 6.354695258301056, "Panniculitis": 25.471415284247072, "Papilloedema": 23.66846701604428, "Pituitary tumour benign": 63.016160763225535, "Pleural adhesion": 349.2422085660759, "Product dose omission issue": 2.4982479017417747, "Product prescribing error": 10.437622371213305, "Protein-losing gastroenteropathy": 185.394968085309, "Scoliosis": 87.56623486100816, "Sleep apnoea syndrome": 37.13542725004547, "Snoring": 88.88864192627597, "Stress": 2.4625437485970263, "Sudden death": 18.379653723577015, "Sulphaemoglobinaemia": 1290.8221809123604, "Therapeutic response unexpected": 3.0383413805651585, "Tonsillar disorder": 271.355272624483, "Type 1 diabetes mellitus": 7.415810809777687, "Type 2 diabetes mellitus": 6.847951891042719, "Viral infection": 4.7167327495039295}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1014.json

@@ -1 +1 @@
-{"Acute kidney injury ": 2.2231581024559484, "Haemorrhoids ": 13.823249904224234, "Oedema ": 5.473815044901856, "Sprue-like enteropathy ": 16.07254395745642}
+{"Intentional overdose": 36.05160301566608}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1015.json

@@ -1 +1 @@
-{"Decreased appetite ": 15.524465486091248, "Hyperammonaemia ": 498.2714011121074}
+{"Alpha 1 foetoprotein increased": 117.58745308698218, "Ascites": 5.550053398271658, "Blister": 3.4120996548188627, "Diarrhoea": 3.3407404264033818, "Disease progression": 5.839117538334553, "Drug ineffective for unapproved indication": 6.258355117317848, "Erythema multiforme": 5.510979238909851, "Haematotoxicity": 11.741519357162655, "Hepatic encephalopathy": 10.293247755647284, "Hepatic failure": 6.0591430036270655, "Hepatocellular carcinoma": 45.14421136202953, "Hepatotoxicity": 5.478867204588851, "Hyperkeratosis": 18.3733643542266, "Hypertension": 3.013407366915988, "Hypocalcaemia": 9.6470695970997, "International normalised ratio increased": 2.1038195462158686, "Malignant neoplasm progression": 2.809789132493224, "Metastases to adrenals": 69.905760963194, "Metastases to bone": 8.459648334480317, "Metastases to liver": 6.502514645388471, "Metastases to lung": 30.543054872294285, "Metastatic renal cell carcinoma": 30.86796027671447, "Mucosal inflammation": 8.28979992726653, "Neoplasm progression": 3.452534897166229, "Off label use": 5.293977606675179, "Osteonecrosis of jaw": 14.70981260897226, "Palmar-plantar erythrodysaesthesia syndrome": 71.92652538146406, "Product use in unapproved indication": 7.835363440653246, "Rash maculo-papular": 2.776626436271433, "Renal cell carcinoma": 15.910019249109528, "Skin exfoliation": 2.8192660283382813, "Skin reaction": 4.758319618050393, "Skin toxicity": 48.99359915368554, "Skin ulcer": 6.50701368486814, "Squamous cell carcinoma of skin": 28.353003645537928, "Stevens-Johnson syndrome": 4.156051349482739, "Thrombocytopenia": 3.780902588912728, "Tumour lysis syndrome": 15.731632606322991, "Weight decreased": 2.306152531961974}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1017.json

@@ -1 +1 @@
-{"Abortion induced ": 55.492594492243846, "Alanine aminotransferase increased ": 3.564923615819831, "Blood alkaline phosphatase increased ": 10.51552654387456, "Drug interaction ": 3.5488844248817992, "Gamma-glutamyltransferase increased ": 13.98440149259873, "Gynaecomastia ": 32.00288477148004, "Hepatic function abnormal ": 6.044500916883304, "Immune reconstitution inflammatory syndrome ": 50.74421148408263, "Insomnia ": 2.223301781918884, "Liver injury ": 11.968814558743084, "Overdose ": 2.905313149425483, "Platelet count decreased ": 2.614785858600858, "Pregnancy ": 36.640987519026496, "Pruritus ": 2.450197395109578, "Rash ": 6.467513327331513, "Suicide attempt ": 5.525759789595508, "Toxic skin eruption ": 23.007443378207885, "Transaminases increased ": 8.512141752935223}
+{"Altered state of consciousness": 2.024050394367631, "Ammonia increased": 7.394131877404162, "Anaemia": 8.55958588248953, "Ascites": 9.094616982559542, "Atrial septal defect": 6.304609474381127, "Autoimmune hepatitis": 4.34647692809549, "Blood bilirubin increased": 7.412695506256812, "Cerebral haemorrhage": 2.4261612946622457, "Cerebral infarction": 3.809744463535769, "Colitis ischaemic": 5.542067546483547, "Death": 2.0131114079317567, "Depression": 2.201360839632474, "Disseminated intravascular coagulation": 2.2543983797041407, "Drug ineffective": 9.32907426444314, "Genotype drug resistance test positive": 15.422815593871432, "Glomerular filtration rate decreased": 4.504709760160125, "Haematemesis": 3.0708755356390083, "Haemoglobin decreased": 8.082692589051026, "Haemolytic anaemia": 12.313385417004216, "Hepatic cancer": 14.629033122198743, "Hepatic cancer recurrent": 602.0039890255414, "Hepatic cirrhosis": 22.786745654044303, "Hepatic encephalopathy": 28.74600624895768, "Hepatic failure": 5.931417114939051, "Hepatic fibrosis": 12.041285487330828, "Hepatitis": 3.55365924842276, "Hepatitis B reactivation": 24.750836315201404, "Hepatitis C": 140.67988130454347, "Hepatitis C RNA increased": 76.9606002229754, "Hepatitis C RNA positive": 259.072465501785, "Hepatitis C virus test positive": 55.05430937726681, "Hepatocellular carcinoma": 48.2368636220552, "Hepatorenal syndrome": 16.059846038349804, "Hyperbilirubinaemia": 19.273544181611605, "Incorrect product administration duration": 6.3377282494176175, "Infection reactivation": 75.01193638089899, "Jaundice": 7.378857502671108, "Loss of consciousness": 2.441367856446145, "Lung neoplasm malignant": 2.0633085005915626, "Lymphoma": 6.231909913666382, "Mood swings": 2.400183233757752, "Multiple organ dysfunction syndrome": 2.8095887428918456, "Neoplasm malignant": 2.3829166882263846, "Oedema peripheral": 2.31561556491414, "Oesophageal varices haemorrhage": 38.12947358924573, "Pancreatitis acute": 2.857094945402418, "Photosensitivity reaction": 2.332324622538988, "Portal vein thrombosis": 15.421635932283817, "Product complaint": 2.159330908377829, "Renal impairment": 4.034343000103323, "Septic shock": 3.187501681052547, "Spontaneous bacterial peritonitis": 47.82313725936973, "Treatment failure": 15.409961112093988, "Treatment noncompliance": 3.1921722220004702, "Unevaluable event": 2.45048167784442, "Upper gastrointestinal haemorrhage": 2.0939908122346926, "Viral load increased": 23.913711484866848, "Virologic failure": 24.4060372416836}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1021.json

@@ -1 +1 @@
-{"Acute generalised exanthematous pustulosis ": 7.403251602720803, "Acute pulmonary oedema ": 8.897214010958006, "Acute respiratory distress syndrome ": 4.355654829220852, "Allergy test negative ": 186.1501833360041, "Anaesthetic complication ": 65.0873203784674, "Anaesthetic complication neurological ": 893.9317810214162, "Anaphylactic reaction ": 16.49165084679229, "Anaphylactic shock ": 109.9967214958737, "Anaphylactoid reaction ": 19.71177305225272, "Anaphylactoid shock ": 212.05232038263395, "Apnoea ": 3.863862385315131, "Atrioventricular block ": 7.754753396190877, "Blood pressure decreased ": 4.48086459989658, "Bradycardia ": 6.111201408025092, "Bradypnoea ": 12.13644301079264, "Bronchospasm ": 67.14935774584228, "Bronchospasm paradoxical ": 74.50156901244907, "Cardiac arrest ": 12.445443274570842, "Cardio-respiratory arrest ": 11.00704668139615, "Cardiogenic shock ": 7.741719728053575, "Cholestasis ": 6.9087089196938845, "Circulatory collapse ": 15.04516960572782, "Coma ": 2.6877120496775144, "Conjunctivitis ": 4.023517925245391, "Cyanosis ": 3.114022813421758, "Eosinophilia ": 6.226639698414206, "Erythema ": 7.066948133596795, "Exposure during pregnancy ": 3.6708429368905486, "Gastritis ": 3.1270129199642613, "Haemodynamic instability ": 18.45473884285001, "Hemiplegia ": 4.1239994903891946, "Hepatic cytolysis ": 7.54066673128345, "Histamine level increased ": 233.4923689841373, "Horner's syndrome ": 157.79323117684072, "Hypersensitivity ": 2.066344387904365, "Hyperthermia malignant ": 133.87630810898844, "Hypotension ": 15.766277213390202, "Hypotonia ": 3.034198419847066, "Hypoxia ": 4.237604610999548, "Inadequate analgesia ": 40.11323721734267, "Incorrect route of product administration ": 2.829203323601296, "Laryngospasm ": 9.679819183490704, "Macule ": 19.15446590647125, "Maternal exposure during delivery ": 66.73311128693486, "Maternal exposure during pregnancy ": 3.148377370358524, "Miosis ": 9.856369291838975, "Myoclonus ": 5.079150875332176, "Neuromuscular blockade ": 151.23454294364646, "Normal newborn ": 9.741556511994713, "Oxygen saturation decreased ": 4.890392953782203, "Paraparesis ": 15.96645380539012, "Pneumonia aspiration ": 5.033002883227971, "Pneumothorax ": 3.622375758224646, "Postoperative delirium ": 809.6657414852194, "Premature baby ": 2.173504966771082, "Procedural hypotension ": 104.79014404852744, "Radiculopathy ": 5.971469817310013, "Rash ": 2.5161780624334424, "Rash maculo-papular ": 4.735983068484234, "Rash morbilliform ": 4.77817246800226, "Respiratory arrest ": 3.5092173992090943, "Respiratory depression ": 21.54729923188729, "Sedation ": 4.0074381768675975, "Sedation complication ": 10.832595028660094, "Shock ": 22.7803855869522, "Shock haemorrhagic ": 4.612095962920212, "Stress cardiomyopathy ": 34.463940685367675, "Tachycardia ": 6.672075120743633, "Toxic epidermal necrolysis ": 2.765564380201957, "Toxic skin eruption ": 5.716324515093811, "Type I hypersensitivity ": 50.08235675337304, "Urinary incontinence ": 2.5027041985782965, "Urticaria ": 4.307513226225706, "Ventricular extrasystoles ": 4.634709394888435, "Ventricular tachycardia ": 2.9120515816660024, "Withdrawal syndrome ": 2.6950279545415987}
+{"Acute generalised exanthematous pustulosis": 11.069981200907966, "Acute kidney injury": 8.417079097333714, "Aortic valve incompetence": 11.26172231608694, "Ascites": 2.1123389108606587, "Asthenia": 3.96594204412715, "Atrial fibrillation": 2.969582946995795, "Atrioventricular block first degree": 35.271465129672414, "Blood bicarbonate decreased": 18.98393803184759, "Blood creatinine increased": 4.858174509291004, "Blood potassium decreased": 6.036230065080136, "Blood potassium increased": 16.08439894050272, "Blood urea increased": 7.34362224347695, "Bradycardia": 4.585396047739196, "Bradykinesia": 10.960219120471624, "Bundle branch block left": 23.00134101042033, "Cardiac amyloidosis": 112.57641288607954, "Cardiac failure": 3.63413761650154, "Cardiac failure acute": 7.207733421182305, "Cardiac failure chronic": 15.211152678003312, "Cardioactive drug level increased": 11.757587920623507, "Cardiomegaly": 4.050939879640464, "Coagulopathy": 4.444699785685563, "Cognitive disorder": 3.053589141704128, "Coronary artery disease": 2.1205898927138405, "Dehydration": 4.62973990273559, "Dementia": 5.34235615452441, "Drug interaction": 3.2489091043062786, "Drug reaction with eosinophilia and systemic symptoms": 6.398986065335149, "Dyspnoea at rest": 14.06076764485153, "Dysuria": 3.1565959007118662, "Electrocardiogram QRS complex prolonged": 22.59997050775363, "Electrocardiogram QT prolonged": 2.031898119005041, "Electrocardiogram T wave peaked": 125.89105712044372, "Electrocardiogram abnormal": 6.037101156183706, "Electrolyte imbalance": 4.820860539541292, "Exercise tolerance decreased": 3.2828705842567687, "Fall": 2.820583647911803, "Fluid retention": 2.7106136534104337, "Gastric polyps": 23.02311044271998, "Glomerular filtration rate decreased": 3.4408901559498477, "Gynaecomastia": 15.513178101531572, "Haematuria": 2.500963812934925, "Heart failure with reduced ejection fraction": 91.6063468955274, "Hiatus hernia": 9.260051774443756, "Hyperkalaemia": 53.25643824405956, "Hypokalaemia": 4.435649942474549, "Hyponatraemia": 10.747136368819334, "Hypophagia": 3.998935340894473, "Hypotension": 5.581615426928849, "Hypovolaemia": 15.790695183996773, "Left ventricular dysfunction": 7.437639440475072, "Medication error": 3.733613773771204, "Metabolic acidosis": 8.099474746460112, "Mitral valve incompetence": 6.87789401907722, "Mobility decreased": 2.238993735330338, "Motor dysfunction": 9.757556232852007, "Multiple organ dysfunction syndrome": 2.988094860664582, "Muscular weakness": 2.532788072135145, "Neuroglycopenia": 249.2446564928584, "Obstructive pancreatitis": 53.390195120476776, "Oedema peripheral": 3.8156087003344368, "Oliguria": 5.317271328580789, "Orthostatic hypotension": 11.740996879867712, "Parkinsonism": 9.590956800928131, "Premature delivery": 3.4885240994097573, "Product prescribing error": 2.581164084378152, "Pulmonary congestion": 5.502253863263049, "Pulmonary oedema": 2.291952274525096, "Rales": 6.715525512405667, "Renal impairment": 2.70428678288886, "Sedation": 2.249928136106992, "Sinus bradycardia": 9.197482761365116, "Stevens-Johnson syndrome": 12.222780166169269, "Tachypnoea": 2.354324392724259, "Toxic epidermal necrolysis": 2.256699705217657, "Transplant dysfunction": 57.04879384223173, "Type 2 diabetes mellitus": 2.372373180506174, "Urine output decreased": 5.1962731173255845, "Ventricular extrasystoles": 3.74426204197182, "Ventricular tachycardia": 5.602339938636116}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1022.json

@@ -1 +1 @@
-{"Anaphylactic reaction ": 45.18999043806067, "Anaphylactic shock ": 25.2329362032695, "Atrial fibrillation ": 8.112470490368743, "Bradycardia ": 22.04753909079276, "Bronchospasm ": 39.75421879118719, "Cardiac arrest ": 16.758361704744704, "Drug interaction ": 9.928121370377337, "Hypotension ": 6.91606460622092, "Neuromuscular block prolonged ": 783.3574580078387, "Neuromuscular blockade ": 1233.7163544188072, "Off label use ": 2.7866687772480945, "Recurrence of neuromuscular blockade ": 1591.5272849619423, "Respiratory failure ": 24.708500671039577, "Tachycardia ": 4.160834080250067}
+{"Acne": 2.893460566737926, "Acute febrile neutrophilic dermatosis": 6.632525313926249, "Acute lymphocytic leukaemia recurrent": 15.998468666897082, "Acute pulmonary oedema": 4.701705370095726, "Adverse event": 11.49143040148586, "Anaemia": 2.383820857328499, "Ascites": 2.69201418445554, "Aspiration pleural cavity": 197.07918646215867, "Atrial fibrillation": 2.229157145126877, "Back disorder": 2.271186757345953, "Blast cell crisis": 109.189024914848, "Blast cell proliferation": 220.8747091943709, "Blast crisis in myelogenous leukaemia": 48.85539172091863, "Blood disorder": 5.009976933338447, "Bone marrow disorder": 24.010438561433023, "Bone marrow failure": 4.064937760298294, "Bone marrow transplant": 57.56143589411527, "Bone pain": 2.4036667824711304, "Cardiac disorder": 2.8228808922218303, "Cardiac failure": 4.093204463628765, "Cardiac failure congestive": 4.367598778334342, "Cardiomegaly": 2.341395871867739, "Cellulitis": 2.1109676609757853, "Chronic myeloid leukaemia": 31.66536682013635, "Chronic myeloid leukaemia recurrent": 67.67375155388085, "Chronic myeloid leukaemia transformation": 63.31810231488716, "Chylothorax": 246.3563302740834, "Clostridium difficile infection": 2.301920483489054, "Colitis": 5.14594226288751, "Cytomegalovirus colitis": 7.744914990893187, "Cytomegalovirus enterocolitis": 20.09020762833893, "Cytopenia": 14.179689451583016, "Death": 3.09455298187857, "Dialysis": 2.040094019183029, "Drug resistance": 2.3760629427418105, "Dyspnoea exertional": 2.16250888703444, "Electrocardiogram QT prolonged": 3.0042365483041027, "Enterocolitis": 4.006317435139912, "Enterocolitis haemorrhagic": 17.93716725282123, "Eye haemorrhage": 2.0008541084455365, "Fluid retention": 13.005368334440652, "Full blood count decreased": 12.55605821348726, "Gallbladder disorder": 2.766055353890416, "Gastrointestinal haemorrhage": 3.396288063688648, "Gastrointestinal infection": 3.6992038061813335, "Gene mutation": 30.12755491850753, "Generalised oedema": 3.0215952709851184, "Graft versus host disease": 4.341178167173663, "Haematochezia": 2.255193461066019, "Haematotoxicity": 4.18158776538611, "Haemorrhage": 2.1732486015628365, "Haemothorax": 9.277347037846702, "Hospitalisation": 12.142961245391785, "Intentional product use issue": 4.016194459524272, "Internal haemorrhage": 4.192102329831255, "Intestinal haemorrhage": 2.676908134644101, "Iron deficiency anaemia": 2.6313255460329703, "Leukaemia": 9.608490019694605, "Leukaemia recurrent": 11.617710539545142, "Lower gastrointestinal haemorrhage": 3.1101176952098406, "Lung disorder": 2.0759857588599435, "Lung infiltration": 4.6469046727646095, "Lymphocytosis": 10.320595242868482, "Malignant neoplasm progression": 11.372091628735523, "Nephrotic syndrome": 4.127880030466489, "Neuropathy peripheral": 2.752704715333511, "Oedema": 2.82796459500404, "Pancytopenia": 5.439390932370854, "Pericardial effusion": 37.583723789601954, "Peripheral arterial occlusive disease": 5.745206768347362, "Philadelphia chromosome positive": 192.4662638449781, "Platelet count decreased": 2.826488156533723, "Platelet count increased": 3.0766663670874514, "Platelet transfusion": 16.0038120670919, "Pleural effusion": 109.1673010576023, "Pleurisy": 14.550612891694469, "Pneumonia": 3.620762731437638, "Pneumonia fungal": 4.46817887476219, "Prescribed underdose": 52.93167860462712, "Pulmonary alveolar haemorrhage": 2.1635207220795505, "Pulmonary arterial hypertension": 29.83150528206673, "Pulmonary congestion": 2.073864447408475, "Pulmonary hypertension": 36.72715378548201, "Pulmonary oedema": 35.807546041200844, "Rectal cancer": 5.135921517206346, "Red blood cell count decreased": 3.0576929227133136, "Respiratory tract congestion": 3.682723173175603, "Retinal haemorrhage": 2.575983980954837, "Right ventricular failure": 3.661962088952216, "Splenomegaly": 4.41393720894199, "Stem cell transplant": 26.56070785679696, "Subdural haematoma": 3.094663916061771, "Therapeutic response decreased": 4.487283938373748, "Therapy non-responder": 4.270333716845658, "Thrombocytopenia": 3.489514739676048, "Transfusion": 8.58733568032972, "Transplant": 8.925170501458705, "Tumour lysis syndrome": 3.264092860971662, "White blood cell count abnormal": 3.2207737585495084, "White blood cell count increased": 3.6235320047540127}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1023.json

@@ -1 +1 @@
-{"Acute hepatic failure ": 16.54972415045368, "Clostridium difficile colitis ": 13.851988879341262, "Decreased appetite ": 2.062683688096459, "Diarrhoea ": 2.794456665558751, "Disease progression ": 13.34261564834975, "Drug interaction ": 6.668701108923167, "Electrocardiogram QT prolonged ": 16.8902170475667, "Epistaxis ": 2.618178916718264, "Hair colour changes ": 30.246649169899676, "Hypertension ": 8.780290190764378, "Hypothyroidism ": 18.01285600587825, "Leukopenia ": 4.028926241635756, "Malignant neoplasm progression ": 4.075736551178736, "Mucosal inflammation ": 17.0382805141317, "Neoplasm progression ": 6.036755141801905, "Nephrotic syndrome ": 23.75094271928633, "Neutropenia ": 4.956532731235687, "Osteonecrosis of jaw ": 86.25154931662397, "Pain in jaw ": 8.918078838186114, "Palmar-plantar erythrodysaesthesia syndrome ": 21.856100254812542, "Periodontal disease ": 259.7499988829635, "Posterior reversible encephalopathy syndrome ": 22.447372708534235, "Proteinuria ": 9.455354143398926, "Stomatitis ": 4.320431895169893, "Thrombocytopenia ": 5.872105572323824, "Thrombotic microangiopathy ": 30.93138083052052}
+{"Completed suicide": 53.30328829485575, "Drug interaction": 16.656255131491992}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1024.json

@@ -1 +1 @@
-{"Agitation ": 3.851180370650725, "Depression ": 4.237372718495712, "Drug interaction ": 3.341036344521052, "Foetal exposure during pregnancy ": 3.8997189349624337, "Gamma-glutamyltransferase increased ": 14.588066774648752, "General physical health deterioration ": 3.373776232891266, "Hallucination ": 4.280479504365571, "Hepatic steatosis ": 13.683564925922584, "Hepatitis ": 8.30024654642637, "Lactic acidosis ": 10.085088378464995, "Nightmare ": 8.542291872123538, "Pancreatitis ": 3.2123651582107637, "Pancreatitis acute ": 12.270590573638067, "Rash maculo-papular ": 7.275481477147968, "Suicidal ideation ": 5.695086941939819}
+{"Abnormal behaviour": 3.405736030382148, "Abnormal dreams": 2.702998184368318, "Aggression": 4.866415552809968, "Agitation": 3.947008318390966, "Akinesia": 60.21426549310371, "Apathy": 2.131198435493688, "Aspiration": 4.96983879617291, "Behaviour disorder": 3.3670274828395783, "Choking": 5.741959648652567, "Chromaturia": 20.417729351749163, "Colitis microscopic": 29.750259077171357, "Confusional state": 4.2149965511639325, "Coordination abnormal": 2.886576406507133, "Dehydration": 2.2680766342227727, "Delirium": 4.6624987622591725, "Delusion": 7.979028547149376, "Dementia": 6.316883951515079, "Disease progression": 3.296813932488486, "Disorientation": 3.98730445254888, "Dopamine dysregulation syndrome": 223.59585536084668, "Dyskinesia": 30.289171692590585, "Dysphagia": 20.125659654680128, "Dysstasia": 5.67475735952977, "Dystonia": 10.376329680771184, "Eating disorder": 3.147996652888444, "Fall": 4.120353612394122, "Feeding disorder": 2.8815379729520307, "Femur fracture": 3.138210888517888, "Fracture": 5.769176202321302, "Freezing phenomenon": 69.77136538612962, "Gait disturbance": 3.877088983650253, "Gait inability": 3.887561247038376, "Gambling disorder": 38.28915995569985, "General physical health deterioration": 3.102061139066422, "Hallucination": 14.215252239620208, "Hallucination, auditory": 3.80876539209585, "Hallucination, visual": 20.04913758685486, "Hip fracture": 3.4761500931010025, "Hyperkinesia": 34.63431122896784, "Hypersexuality": 88.54307920972444, "Hypokinesia": 10.896466820444084, "Ileus": 6.712852956988915, "Impulse-control disorder": 33.91390444203331, "Incorrect dose administered": 2.822161459869556, "Libido increased": 20.785353313834342, "Motor dysfunction": 5.006339917569944, "Movement disorder": 5.751234979080472, "Muscle rigidity": 16.086162379776695, "Musculoskeletal stiffness": 3.3576030236252605, "Nervousness": 3.309137962557001, "Neuroleptic malignant syndrome": 3.49465684394376, "Nightmare": 2.5097010206155463, "On and off phenomenon": 227.7982496854132, "Oral mucosal discolouration": 96.12341708593657, "Orthostatic hypotension": 6.362135201932418, "Paralysis": 4.33061368972657, "Paranoia": 5.749322435225319, "Parkinson's disease": 196.40166614224387, "Parkinsonian crisis": 840.9120212576136, "Parkinsonism": 7.755478468608146, "Pneumonia aspiration": 8.312145081727648, "Product complaint": 20.89472713737045, "Product prescribing error": 4.978415313901908, "Product quality issue": 2.3635455221260697, "Product residue present": 10.629254931708047, "Product size issue": 27.248367343819105, "Product supply issue": 35.574906451178286, "Product use complaint": 12.432151262976552, "Psychomotor hyperactivity": 11.438706786685517, "Psychotic disorder": 4.340717643291604, "Rhabdomyolysis": 2.870390291627024, "Salivary hypersecretion": 5.169761978430663, "Serotonin syndrome": 2.6394945306584607, "Somnolence": 2.16104717746886, "Speech disorder": 4.318665600082211, "Stereotypy": 36.10581657759274, "Sudden onset of sleep": 37.57989661377093, "Therapeutic product effect decreased": 2.360618906236981, "Therapeutic response shortened": 38.01429181564257, "Therapy cessation": 11.894260365424236, "Tremor": 4.080156149610642, "Urinary tract infection": 2.007486362317123, "Weight decreased": 2.2238754835402563, "Wrong technique in product usage process": 16.15472535526383}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1027.json

@@ -1 +1 @@
-{"Disease progression ": 17.14924489097697, "Infusion related reaction ": 10.35582239423618, "Neutropenia ": 3.979092548281306, "Off label use ": 6.3660227809156655, "Pneumonia ": 2.8100841058076487, "Thrombocytopenia ": 4.5412374530405}
+{"Acute kidney injury": 2.2231581024559484, "Haemorrhoids": 13.823249904224234, "Oedema": 5.473815044901856, "Sprue-like enteropathy": 16.07254395745642}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1028.json

@@ -1 +1 @@
-{"Blood HIV RNA increased ": 181.838687104936, "Blood cholesterol increased ": 5.4785669164247714, "Coronavirus infection ": 52.27277024392599, "Dyslipidaemia ": 89.77957649352986, "Hypercholesterolaemia ": 53.33628903283755, "Pruritus ": 2.458791050041042, "Rash ": 3.1162971265395707, "Self-destructive behaviour ": 50.20958343048842, "Treatment noncompliance ": 10.059402853288685, "Viral load increased ": 104.16448448730864, "Weight increased ": 4.092895577177306}
+{"Decreased appetite": 15.524314913312612, "Hyperammonaemia": 498.2714011121074}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1030.json

@@ -1 +1 @@
-{"Bronchiolitis ": 779.166294388646, "Bronchitis ": 12.84332727274147, "Cough ": 3.714649392294732, "Crying ": 9.760082668090943, "Cyanosis ": 15.050539805386926, "Febrile convulsion ": 104.2446634797766, "Gait disturbance ": 2.308275650073966, "Gastroenteritis ": 49.50427881908052, "Hypotonia ": 15.496026164217271, "Hypotonic-hyporesponsive episode ": 157.4062306832819, "Nasopharyngitis ": 5.439428078260963, "Otitis media ": 171.24733030314465, "Pharyngitis ": 41.241806972258544, "Pharyngotonsillitis ": 1141.1071288927312, "Pneumonia ": 2.5341077722995995, "Pyrexia ": 3.21711157386507, "Rhinorrhoea ": 6.683469626978567, "Seizure ": 2.5738113434731185, "Tonsillitis ": 50.87302756135354, "Upper respiratory tract infection ": 36.55224574583768}
+{"Abortion induced": 55.492594492243846, "Alanine aminotransferase increased": 3.564923615819831, "Blood alkaline phosphatase increased": 10.51552654387456, "Drug interaction": 3.5488844248817992, "Gamma-glutamyltransferase increased": 13.98440149259873, "Gynaecomastia": 32.00288477148004, "Hepatic function abnormal": 6.044500916883304, "Immune reconstitution inflammatory syndrome": 50.74421148408263, "Insomnia": 2.223301781918884, "Liver injury": 11.968814558743084, "Overdose": 2.905313149425483, "Platelet count decreased": 2.614785858600858, "Pregnancy": 36.640987519026496, "Pruritus": 2.45016771698168, "Rash": 6.467424469518315, "Suicide attempt": 5.525759789595508, "Toxic skin eruption": 23.007443378207885, "Transaminases increased": 8.51162050351136}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1031.json

@@ -1 +1 @@
-{"Acute graft versus host disease ": 9.556973829554424, "Acute kidney injury ": 4.632972201997329, "Aplasia pure red cell ": 9.435409341152765, "Aspergillus infection ": 13.91952464524402, "Bacterial infection ": 4.539085156493998, "Blood creatinine increased ": 3.813735773258565, "Blood magnesium decreased ": 14.473511721623495, "Bronchopulmonary aspergillosis ": 15.253063593946726, "Candida infection ": 13.267752348376414, "Complications of transplanted kidney ": 74.50705244939448, "Contraindicated product administered ": 2.7845585326378406, "Cytomegalovirus infection ": 15.157237278663734, "Cytomegalovirus infection reactivation ": 11.550805057576676, "Cytomegalovirus viraemia ": 20.03520013050089, "Delirium ": 3.1871101315817185, "Diffuse large B-cell lymphoma ": 9.65208618744716, "Drug interaction ": 15.81470973551902, "Drug level below therapeutic ": 20.324218023469687, "Drug level decreased ": 20.65286278363047, "Drug level increased ": 28.988626951777054, "Drug-induced liver injury ": 2.439295289009844, "Electrocardiogram QT prolonged ": 3.153313608304094, "Electrolyte imbalance ": 11.05953188385152, "Encephalopathy ": 3.0534522890184603, "Epstein-Barr virus infection ": 14.84013748743892, "Foetal exposure during pregnancy ": 2.2210328204057324, "Fungal infection ": 6.374138011007898, "Gastric ulcer ": 3.836088753065124, "Graft versus host disease ": 26.73033623851588, "Graft versus host disease in gastrointestinal tract ": 27.46189931928016, "Hepatotoxicity ": 2.315869496282281, "Hiccups ": 7.0034951531256535, "Hyperkalaemia ": 9.20247570669359, "Immunosuppressant drug level decreased ": 248.0418648889223, "Immunosuppressant drug level increased ": 264.6432124536741, "Kidney transplant rejection ": 43.66762927488129, "Labelled drug-drug interaction medication error ": 8.395399340523921, "Leukopenia ": 2.2104064797681637, "Liver transplant rejection ": 108.23083641779152, "Mental status changes ": 4.740266931794532, "Multiple organ dysfunction syndrome ": 2.2936034813393302, "Nephropathy toxic ": 26.15257354673421, "Neurotoxicity ": 11.378608573956864, "Nocardiosis ": 66.56801510090207, "Oesophageal candidiasis ": 15.158382280624116, "Off label use ": 2.29665066997234, "Peritonitis ": 9.178477286389231, "Polyomavirus-associated nephropathy ": 70.68430142199296, "Post transplant lymphoproliferative disorder ": 23.09285420269395, "Posterior reversible encephalopathy syndrome ": 13.802264725416752, "Premature baby ": 6.992214468985721, "Premature delivery ": 3.789818494331719, "Renal impairment ": 4.091469548624541, "Renal tubular necrosis ": 6.980908071945522, "Respiratory failure ": 2.017375804077936, "Scedosporium infection ": 118.72095024196096, "Septic shock ": 2.38036609686691, "Skin lesion ": 3.007428543531706, "Squamous cell carcinoma of skin ": 21.68212317763691, "Staphylococcal infection ": 3.4611760965196705, "Thrombotic microangiopathy ": 24.854055910318632, "Toxicity to various agents ": 4.897400962091449, "Transplant rejection ": 48.36680142436104, "Tuberculosis ": 7.325966222814844, "Varicella zoster virus infection ": 22.159620992696937}
+{"Acute kidney injury": 3.837093010245585, "Adrenal suppression": 6.897087185349649, "Anhedonia": 37.93305612535252, "Ankle fracture": 16.419407186686197, "Anxiety": 9.74465712378995, "Blood HIV RNA increased": 8.017341240353831, "Blood creatine increased": 3.9269584221099176, "Blood creatinine abnormal": 7.6005497975066785, "Blood creatinine increased": 6.959423137482869, "Blood phosphorus decreased": 3.7996629517840974, "Bone cyst": 12.0161605234461, "Bone demineralisation": 39.78471389191874, "Bone density abnormal": 44.9800487963953, "Bone density decreased": 41.367314904971614, "Bone disorder": 9.567419231356164, "Bone loss": 44.070120219291205, "CD4 lymphocytes decreased": 7.833713108836502, "Cervical vertebral fracture": 4.16721827273374, "Chronic kidney disease": 29.96502828292687, "Chronic kidney disease-mineral and bone disorder": 14.579060174187846, "Clavicle fracture": 11.025723719402247, "Compression fracture": 5.807050585340042, "Craniofacial fracture": 5.086296515270692, "Decreased activity": 8.72562595648275, "Degenerative bone disease": 38.18806742020685, "Dental caries": 4.099300429734812, "Depression": 2.185897463030438, "Drug resistance": 2.2244384333546305, "Dysstasia": 4.082773270989218, "Economic problem": 47.41659546093008, "Emotional distress": 31.391290817044823, "End stage renal disease": 13.156522103308722, "Fanconi syndrome": 6.001312126304554, "Fanconi syndrome acquired": 17.07001337853639, "Fear-related avoidance of activities": 44.68238171689551, "Femur fracture": 4.241734620439612, "Fibula fracture": 11.484953535141832, "Foot fracture": 13.093899613779907, "Fracture": 24.913703256263304, "Fractured coccyx": 7.70458096946798, "Gene mutation identification test positive": 16.558650560064695, "Genotype drug resistance test positive": 10.881243385437315, "Glomerular filtration rate abnormal": 19.99977407824438, "Glomerular filtration rate decreased": 7.059146965188791, "Glomerular filtration rate increased": 11.120092820898366, "HIV test positive": 8.126243426562583, "Hand fracture": 22.87269317018801, "Hepatitis B": 2.094615756278807, "Hip arthroplasty": 6.665369088413817, "Hip fracture": 5.156764603971011, "Hip surgery": 3.8955786074570313, "Humerus fracture": 3.2049474000090923, "Immune reconstitution inflammatory syndrome": 3.661143387132785, "Impaired work ability": 2.0435730049528598, "Intervertebral disc degeneration": 6.914664223853307, "Jaw fracture": 9.851149821781922, "Loss of personal independence in daily activities": 2.9151883326726065, "Lower limb fracture": 6.724854728671521, "Meniscus injury": 2.8838998318480638, "Multiple fractures": 39.76729575086082, "Nephrolithiasis": 3.558028936981078, "Nephropathy": 14.935658524312323, "Nephropathy toxic": 16.302223077865932, "Osteoarthritis": 4.125715809934811, "Osteochondrosis": 9.733075617096606, "Osteomalacia": 15.30060678883252, "Osteonecrosis": 40.16079280889993, "Osteopenia": 31.278487027827527, "Osteoporosis": 31.576430709141217, "Osteoporotic fracture": 4.512159499609686, "Pain": 4.357722095545041, "Patella fracture": 4.065729447325782, "Pathological fracture": 5.419408444349534, "Pelvic fracture": 2.0078561174450296, "Post-traumatic stress disorder": 4.149638767731106, "Protein total abnormal": 38.08103452661691, "Protein total increased": 16.158653148413833, "Protein urine present": 12.203197917789748, "Proteinuria": 4.7347056716076406, "Quality of life decreased": 8.731561370371342, "Radius fracture": 5.277221955770337, "Renal cyst": 2.4887361267350983, "Renal failure": 16.00421654754964, "Renal impairment": 5.999427301353714, "Renal injury": 25.85561510833812, "Renal tubular disorder": 5.482068065821315, "Renal tubular dysfunction": 5.2914957233283, "Renal tubular necrosis": 2.957742685840929, "Rib fracture": 12.038808566425972, "Shoulder fracture": 7.770960339319937, "Skeletal injury": 24.51679949132032, "Spinal compression fracture": 8.189066809692145, "Spinal disorder": 3.0617460029340062, "Spinal fracture": 9.637133745949392, "Spinal osteoarthritis": 8.63799507832165, "Spinal stenosis": 3.0833051558831768, "Spondylolisthesis": 11.455756623183191, "Stress fracture": 8.399935519389151, "Teeth brittle": 23.07609301873647, "Thoracic vertebral fracture": 3.348862490082252, "Tibia fracture": 10.712464721935309, "Toe amputation": 2.4233715198134385, "Tooth disorder": 3.680807680656984, "Tooth extraction": 5.042597811637255, "Tooth fracture": 21.65263019670649, "Tooth loss": 36.9627791881238, "Ulna fracture": 12.727599742554318, "Upper limb fracture": 6.600377437949353, "Vertebral foraminal stenosis": 22.88510668025476, "Viral load increased": 9.588219359523416, "Viral mutation identified": 7.4161622485859, "Virologic failure": 8.415654762306158, "Vitamin D decreased": 5.153770237075881, "Vitamin D deficiency": 14.623116481880254, "Walking aid user": 4.229195771901956, "Wrist fracture": 12.41062327368115}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1033.json

@@ -1 +1 @@
-{"Acute kidney injury ": 6.895030961377874, "Cardiac failure ": 15.080049937098195, "Dyspnoea ": 2.0852597649905174, "Syncope ": 8.648635389357425}
+{"Amnesia": 58.49653583304914, "Anxiety": 2.5182975219052115, "Chemical submission": 19458.108500057097, "Drug abuse": 86.9809708477372, "Drug dependence": 7.616059680106968, "Injection": 13466.474301417627, "Loss of consciousness": 4.456619762196874, "Somnolence": 3.336453482080453, "Substance abuse": 39.7798324017028, "Vomiting": 2.04686078547525}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1034.json

@@ -1 +1 @@
-{"Asthenia ": 2.0298473465254023, "Cardiac failure ": 2.1328680971681124, "Death ": 6.644593702886772, "Disease progression ": 2.428502090800721, "Dysphagia ": 5.337199756249735, "General physical health deterioration ": 2.256908028393501, "Hospitalisation ": 3.607536407949742, "Hyperkeratosis ": 31.339646439611634, "Hyperpyrexia ": 16.748828454881412, "Malignant melanoma ": 26.51803200313268, "Malignant neoplasm progression ": 10.074603566996371, "Metastases to central nervous system ": 35.97684734159338, "Metastases to lung ": 10.738587887181808, "Metastatic malignant melanoma ": 127.91629892137396, "Neutropenia ": 2.019760512205349, "Palmoplantar keratoderma ": 337.1039155598279, "Product use in unapproved indication ": 2.324612050438269, "Pyrexia ": 3.2417323990065148, "Skin papilloma ": 56.4605016308825, "Uveitis ": 33.144610733618265}
+{"Acute generalised exanthematous pustulosis": 7.403251602720803, "Acute pulmonary oedema": 8.897214010958006, "Acute respiratory distress syndrome": 4.355654829220852, "Allergy test negative": 186.1501833360041, "Anaesthetic complication": 65.0873203784674, "Anaesthetic complication neurological": 893.9317810214162, "Anaphylactic reaction": 16.491298678692914, "Anaphylactic shock": 109.9967214958737, "Anaphylactoid reaction": 19.71177305225272, "Anaphylactoid shock": 212.05232038263395, "Apnoea": 3.863862385315131, "Atrioventricular block": 7.754753396190877, "Blood pressure decreased": 4.480719009294605, "Bradycardia": 6.111009571809047, "Bradypnoea": 12.13644301079264, "Bronchospasm": 67.14935774584228, "Bronchospasm paradoxical": 74.50156901244907, "Cardiac arrest": 12.445443274570842, "Cardio-respiratory arrest": 11.00704668139615, "Cardiogenic shock": 7.741719728053575, "Cholestasis": 6.9087089196938845, "Circulatory collapse": 15.04516960572782, "Coma": 2.6877120496775144, "Conjunctivitis": 4.023517925245391, "Cyanosis": 3.113441726415781, "Eosinophilia": 6.226639698414206, "Erythema": 7.066878871803732, "Exposure during pregnancy": 3.6708429368905486, "Gastritis": 3.1270129199642613, "Haemodynamic instability": 18.45473884285001, "Hemiplegia": 4.1239994903891946, "Hepatic cytolysis": 7.54066673128345, "Histamine level increased": 233.4923689841373, "Horner's syndrome": 157.79323117684072, "Hypersensitivity": 2.066344387904365, "Hyperthermia malignant": 133.87630810898844, "Hypotension": 15.765911032941878, "Hypotonia": 3.0338722906143767, "Hypoxia": 4.237604610999548, "Inadequate analgesia": 40.11323721734267, "Incorrect route of product administration": 2.829203323601296, "Laryngospasm": 9.679819183490704, "Macule": 19.15446590647125, "Maternal exposure during delivery": 66.73311128693486, "Maternal exposure during pregnancy": 3.148377370358524, "Miosis": 9.856369291838975, "Myoclonus": 5.079150875332176, "Neuromuscular blockade": 151.23454294364646, "Normal newborn": 9.741556511994713, "Oxygen saturation decreased": 4.890130986763746, "Paraparesis": 15.96645380539012, "Pneumonia aspiration": 5.033002883227971, "Pneumothorax": 3.622375758224646, "Postoperative delirium": 809.6657414852194, "Premature baby": 2.173504966771082, "Procedural hypotension": 104.79014404852744, "Radiculopathy": 5.971469817310013, "Rash": 2.5161434758775045, "Rash maculo-papular": 4.735983068484234, "Rash morbilliform": 4.77817246800226, "Respiratory arrest": 3.5092173992090943, "Respiratory depression": 21.54729923188729, "Sedation": 4.0074381768675975, "Sedation complication": 10.832595028660094, "Shock": 22.7803855869522, "Shock haemorrhagic": 4.612095962920212, "Stress cardiomyopathy": 34.463940685367675, "Tachycardia": 6.671906180203018, "Toxic epidermal necrolysis": 2.765564380201957, "Toxic skin eruption": 5.716324515093811, "Type I hypersensitivity": 50.08235675337304, "Urinary incontinence": 2.5027041985782965, "Urticaria": 4.307469041577118, "Ventricular extrasystoles": 4.634709394888435, "Ventricular tachycardia": 2.9120515816660024, "Withdrawal syndrome": 2.6950279545415987}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1035.json

@@ -1 +1 @@
-{"Acne ": 3.9817893001292526, "Acquired gene mutation ": 14.86060427971434, "Aplastic anaemia ": 2.4584023089024867, "Atelectasis ": 2.37771660757051, "Blood creatine phosphokinase increased ": 2.6123542299220905, "Blood sodium decreased ": 2.0135075514031517, "Body height decreased ": 4.185769001700461, "Brain neoplasm ": 6.644883522038496, "Brain oedema ": 3.1302435548088, "Carcinoembryonic antigen increased ": 42.61673227311675, "Cardiac dysfunction ": 12.327542922884517, "Cardiac failure ": 8.521493177010159, "Cardiac failure acute ": 5.251452961857661, "Cardiac failure chronic ": 3.822153430360925, "Cardiac failure congestive ": 2.5075023229947604, "Cardiac tamponade ": 5.463955370606241, "Cardiomyopathy ": 5.997049806132496, "Cardiotoxicity ": 4.967330641045299, "Cerebral infarction ": 3.4034875300558856, "Conjunctivitis ": 2.064826211216725, "Cutaneous vasculitis ": 3.395635663936643, "Decreased appetite ": 3.320458532718724, "Deep vein thrombosis ": 2.185114127131098, "Dermatitis ": 3.846071887202495, "Dermatitis acneiform ": 23.26756462073814, "Diarrhoea ": 3.4768139923517114, "Dilated cardiomyopathy ": 3.147025142157053, "Disease progression ": 2.480300105556443, "Drug eruption ": 2.929434774742854, "Drug resistance ": 4.47367629226466, "Dry eye ": 2.448772686386256, "Dry skin ": 9.05282648504712, "EGFR gene mutation ": 44.62231329418593, "Ejection fraction decreased ": 11.295137675058209, "Electrocardiogram QT prolonged ": 14.629520935685772, "Erythema multiforme ": 5.641609336630526, "Feeding disorder ": 3.094787333093971, "Femur fracture ": 2.416476449857122, "Fracture ": 2.645747600499752, "Haematotoxicity ": 2.965636279316429, "Haemoptysis ": 2.417693027600344, "Heart failure with reduced ejection fraction ": 28.31332695155776, "Hepatic function abnormal ": 2.429688221568133, "Hypophagia ": 2.2703870435921254, "Interstitial lung disease ": 47.55755804580372, "Keratitis ": 19.58168248049645, "Liver disorder ": 3.2453349166959704, "Long QT syndrome ": 15.736520794768186, "Lung disorder ": 8.477348622658056, "Lung infiltration ": 2.1073581419576777, "Lung neoplasm malignant ": 8.157281600255411, "Lung opacity ": 22.832835082362784, "Lymphangiosis carcinomatosa ": 54.89363797859607, "Malignant neoplasm progression ": 23.07686060217942, "Malignant pleural effusion ": 16.791500949232315, "Metastases to bone ": 16.023886140613364, "Metastases to central nervous system ": 50.12358179331599, "Metastases to liver ": 7.575937267365127, "Metastases to lung ": 6.587186732999116, "Metastases to lymph nodes ": 7.505266377899103, "Metastases to meninges ": 80.14189619352831, "Metastases to pleura ": 27.48685934398338, "Metastases to spine ": 15.279311033087652, "Metastasis ": 19.640796287052037, "Mouth ulceration ": 2.0692533413201595, "Mucosal disorder ": 6.642481227070001, "Mucosal inflammation ": 3.283513389119108, "Myelosuppression ": 2.6984300502336844, "Nail bed inflammation ": 116.04007033133642, "Nail disorder ": 27.50616212964865, "Neoplasm progression ": 2.3573911721813654, "Neutrophil count decreased ": 2.1104475114733785, "No adverse event ": 2.7729909872459397, "Non-small cell lung cancer ": 11.60562978054623, "Onychoclasis ": 37.42974064973691, "Paronychia ": 140.35659557675618, "Pericardial effusion ": 3.709610246804262, "Platelet count decreased ": 4.392614564417044, "Pleural effusion ": 10.054866459723204, "Pneumocystis jirovecii pneumonia ": 2.552700740824178, "Pneumonia aspiration ": 2.26254680295525, "Pneumonia bacterial ": 8.470957817758496, "Pneumonitis ": 41.91260667605256, "Pneumothorax ": 6.265809169077893, "Pulmonary alveolar haemorrhage ": 4.041715289510191, "Pulmonary embolism ": 3.061761150380486, "Pulmonary mass ": 2.911086503171793, "Pulmonary oedema ": 2.745842825195677, "Pulmonary toxicity ": 63.23391072785357, "Pustule ": 2.946345586943139, "Rash ": 2.3210499514289067, "Recurrent cancer ": 10.40935008333442, "Respiratory failure ": 2.934398323478125, "SARS-CoV-2 test negative ": 12.007149456124772, "Skin disorder ": 5.413889254239975, "Skin fissures ": 16.32960554174431, "Skin toxicity ": 7.827041959957261, "Skin ulcer ": 2.032602812468616, "Small cell lung cancer ": 21.49811021775693, "Stomatitis ": 5.472740746696174, "Taste disorder ": 3.310603632309159, "Thrombocytopenia ": 3.9547086574369006, "Torsade de pointes ": 2.3862463935662435, "Tumour marker increased ": 11.272312365499168}
+{"Anaphylactic reaction": 45.18902925887953, "Anaphylactic shock": 25.2329362032695, "Atrial fibrillation": 8.112249070660205, "Bradycardia": 22.046847964900927, "Bronchospasm": 39.75421879118719, "Cardiac arrest": 16.758361704744704, "Drug interaction": 9.928121370377337, "Hypotension": 6.915904718605427, "Neuromuscular block prolonged": 783.3574580078387, "Neuromuscular blockade": 1233.7163544188072, "Off label use": 2.786559025276401, "Recurrence of neuromuscular blockade": 1591.5272849619423, "Respiratory failure": 24.706460043659813, "Tachycardia": 4.160728933769897}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1036.json

@@ -1 +1 @@
-{"Injection site pain ": 2.943991133840602}
+{"Acute hepatic failure": 16.54972415045368, "Clostridium difficile colitis": 13.851988879341262, "Decreased appetite": 2.062663679196262, "Diarrhoea": 2.794433340307961, "Disease progression": 13.34261564834975, "Drug interaction": 6.668701108923167, "Electrocardiogram QT prolonged": 16.8902170475667, "Epistaxis": 2.618178916718264, "Hair colour changes": 30.246649169899676, "Hypertension": 8.780199481446322, "Hypothyroidism": 18.01285600587825, "Leukopenia": 4.028418329041707, "Malignant neoplasm progression": 4.075736551178736, "Mucosal inflammation": 17.0382805141317, "Neoplasm progression": 6.036755141801905, "Nephrotic syndrome": 23.75094271928633, "Neutropenia": 4.956319524288265, "Osteonecrosis of jaw": 86.25154931662397, "Pain in jaw": 8.918078838186114, "Palmar-plantar erythrodysaesthesia syndrome": 21.856100254812542, "Periodontal disease": 259.7499988829635, "Posterior reversible encephalopathy syndrome": 22.447372708534235, "Proteinuria": 9.455354143398926, "Stomatitis": 4.320431895169893, "Thrombocytopenia": 5.871552950238839, "Thrombotic microangiopathy": 30.93138083052052}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1040.json

@@ -1 +1 @@
-{"Confusional state ": 5.669563911778029, "Dyskinesia ": 28.03310513943156}
+{"Disease progression": 17.14924489097697, "Infusion related reaction": 10.35582239423618, "Neutropenia": 3.97892145707637, "Off label use": 6.3657720319622015, "Pneumonia": 2.8100841058076487, "Thrombocytopenia": 4.540810287748204}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1041.json

@@ -1 +1 @@
-{"Acute myeloid leukaemia ": 24.392855630902638, "Agranulocytosis ": 32.64999280948443, "Alopecia ": 15.24131808896068, "Breast cancer ": 2.3841679570405825, "Cardiac failure ": 3.704832408648704, "Diarrhoea ": 2.6104785225720466, "Febrile bone marrow aplasia ": 47.19696517020128, "Febrile neutropenia ": 10.331509711212863, "Flushing ": 3.3897819379479044, "Granulocytopenia ": 10.188942004006318, "Hepatic function abnormal ": 2.8702610770476173, "Interstitial lung disease ": 8.553226188585219, "Leukopenia ": 15.417388750327724, "Lung disorder ": 2.001515387755858, "Malignant neoplasm progression ": 2.4246877508444062, "Mucosal inflammation ": 10.3136214171609, "Myelosuppression ": 17.546431551703954, "Neuropathy peripheral ": 2.272630804462859, "Neutropenia ": 8.59562045425204, "Neutrophil count decreased ": 13.76337197432074, "Oedema ": 3.1204572923275715, "Palmar-plantar erythrodysaesthesia syndrome ": 4.153081478533539, "Pancytopenia ": 3.252733923666057, "Pleural effusion ": 2.617807302711724, "Pneumonitis ": 3.392565185806798, "Prostatic specific antigen increased ": 8.12737713949123, "Psychological trauma ": 231.20972511778865, "Sepsis ": 2.791674046342254, "Septic shock ": 4.0061911267247465, "Skin exfoliation ": 4.51448753622689, "Stomatitis ": 9.298416330429918, "White blood cell count decreased ": 15.763995605032802}
+{"Blood HIV RNA increased": 181.838687104936, "Blood cholesterol increased": 5.4785669164247714, "Coronavirus infection": 52.27277024392599, "Dyslipidaemia": 89.77957649352986, "Hypercholesterolaemia": 53.33628903283755, "Pruritus": 2.458761266839211, "Rash": 3.1162543163507226, "Self-destructive behaviour": 50.20958343048842, "Treatment noncompliance": 10.059402853288685, "Viral load increased": 104.16448448730864, "Weight increased": 4.092895577177306}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1043.json

@@ -1 +1 @@
-{"Drug resistance ": 254.29199408251824, "Off label use ": 23.720787754991523}
+{"Bronchiolitis": 778.7056142568129, "Bronchitis": 12.842557096153971, "Cough": 3.714614937402436, "Crying": 9.757838990373523, "Cyanosis": 15.047732238951893, "Febrile convulsion": 104.20822628646177, "Gait disturbance": 2.308233809316597, "Gastroenteritis": 49.50427881908052, "Hypotonia": 15.49436104679001, "Hypotonic-hyporesponsive episode": 157.4062306832819, "Nasopharyngitis": 5.439013643771641, "Otitis media": 171.24733030314465, "Pharyngitis": 41.23229230924512, "Pharyngotonsillitis": 1141.1071288927312, "Pneumonia": 2.5341077722995995, "Pyrexia": 3.217042861448929, "Rhinorrhoea": 6.683469626978567, "Seizure": 2.5735260394938924, "Tonsillitis": 50.87302756135354, "Upper respiratory tract infection": 36.55224574583768}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1044.json

@@ -1 +1 @@
-{"Abdominal discomfort ": 5.1277662364354, "Abdominal distension ": 11.791425764328764, "Abdominal pain upper ": 2.1040598194208058, "Anxiety ": 2.4321796793193515, "Apathy ": 24.39302440109842, "Back pain ": 3.826840705334224, "Balance disorder ": 5.616529568335016, "Body temperature increased ": 3.9373600003290776, "Brain fog ": 23.49891729025513, "Compression fracture ": 119.8384336569958, "Contusion ": 4.422667764151881, "Cough ": 2.187113554942866, "Defaecation urgency ": 132.73646066353425, "Depressed level of consciousness ": 7.300647887370133, "Depression ": 2.2494264745268424, "Eructation ": 49.804557220690185, "Faeces hard ": 250.41818787072893, "Fall ": 2.483299481729722, "Feeding disorder ": 22.985848965815062, "Feeling abnormal ": 5.367405670299214, "Flatulence ": 24.45448797963413, "Frequent bowel movements ": 42.81589314851118, "Gastrointestinal stoma complication ": 831.550395288055, "Gastrointestinal stoma output abnormal ": 9578.639330348751, "Hiccups ": 52.586467848788864, "Hot flush ": 6.6337027206923445, "Hypersomnia ": 19.10133681389019, "Insomnia ": 2.7702106056602864, "Intestinal obstruction ": 49.144941412122165, "Joint swelling ": 4.895485853124828, "Lethargy ": 5.601716806197969, "Lumbar vertebral fracture ": 132.1628924135092}
+{"Acute graft versus host disease": 9.556973829554424, "Acute kidney injury": 4.632972201997329, "Aplasia pure red cell": 9.435409341152765, "Aspergillus infection": 13.91952464524402, "Bacterial infection": 4.539085156493998, "Blood creatinine increased": 3.813735773258565, "Blood magnesium decreased": 14.473511721623495, "Bronchopulmonary aspergillosis": 15.253063593946726, "Candida infection": 13.267752348376414, "Complications of transplanted kidney": 74.50705244939448, "Contraindicated product administered": 2.7845585326378406, "Cytomegalovirus infection": 15.157237278663734, "Cytomegalovirus infection reactivation": 11.550805057576676, "Cytomegalovirus viraemia": 20.03520013050089, "Delirium": 3.1871101315817185, "Diffuse large B-cell lymphoma": 9.65208618744716, "Drug interaction": 15.81470973551902, "Drug level below therapeutic": 20.324218023469687, "Drug level decreased": 20.65286278363047, "Drug level increased": 28.988626951777054, "Drug-induced liver injury": 2.4391465791004365, "Electrocardiogram QT prolonged": 3.153313608304094, "Electrolyte imbalance": 11.05953188385152, "Encephalopathy": 3.0534522890184603, "Epstein-Barr virus infection": 14.84013748743892, "Foetal exposure during pregnancy": 2.2210328204057324, "Fungal infection": 6.372367484662919, "Gastric ulcer": 3.8335378448649, "Graft versus host disease": 26.73033623851588, "Graft versus host disease in gastrointestinal tract": 27.46189931928016, "Hepatotoxicity": 2.315869496282281, "Hiccups": 7.0034951531256535, "Hyperkalaemia": 9.201204064119976, "Immunosuppressant drug level decreased": 248.0418648889223, "Immunosuppressant drug level increased": 264.6432124536741, "Kidney transplant rejection": 43.66762927488129, "Labelled drug-drug interaction medication error": 8.395399340523921, "Leukopenia": 2.2101277584479933, "Liver transplant rejection": 108.23083641779152, "Mental status changes": 4.740266931794532, "Multiple organ dysfunction syndrome": 2.2936034813393302, "Nephropathy toxic": 26.15257354673421, "Neurotoxicity": 11.378608573956864, "Nocardiosis": 66.56801510090207, "Oesophageal candidiasis": 15.158382280624116, "Off label use": 2.2965601647263867, "Peritonitis": 9.178477286389231, "Polyomavirus-associated nephropathy": 70.68430142199296, "Post transplant lymphoproliferative disorder": 23.09285420269395, "Posterior reversible encephalopathy syndrome": 13.802264725416752, "Premature baby": 6.992214468985721, "Premature delivery": 3.789818494331719, "Renal impairment": 4.091469548624541, "Renal tubular necrosis": 6.980908071945522, "Respiratory failure": 2.0172091985146725, "Scedosporium infection": 118.72095024196096, "Septic shock": 2.38036609686691, "Skin lesion": 3.007428543531706, "Squamous cell carcinoma of skin": 21.68212317763691, "Staphylococcal infection": 3.4611760965196705, "Thrombotic microangiopathy": 24.854055910318632, "Toxicity to various agents": 4.897400962091449, "Transplant rejection": 48.36680142436104, "Tuberculosis": 7.325966222814844, "Varicella zoster virus infection": 22.159620992696937}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1045.json

@@ -1 +1 @@
-{"Abdominal pain ": 2.595551872054118, "Fall ": 4.650298968905808}
+{"Basal cell carcinoma": 45.30284295792817, "Blood pressure increased": 2.6807247592811034, "Cardiac failure": 6.523497642483212, "Drug interaction": 2.4814046230106723, "Malignant melanoma": 27.122319976752102, "Respiratory syncytial virus infection": 47.11616481082915, "Toxicity to various agents": 3.4816910427180288}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1046.json

@@ -1 +1 @@
-{"Anaemia ": 2.7779060769933666, "Cytopenia ": 19.408090829709096, "Decreased appetite ": 7.484137183796419, "Diarrhoea ": 2.6546182154293465, "Febrile neutropenia ": 2.600021384872554, "Gastrointestinal disorder ": 3.3255390937417397, "Granulocyte count decreased ": 35.40515316876338, "Haemoglobin decreased ": 6.601374361586855, "Interstitial lung disease ": 5.915587462163558, "Leukopenia ": 9.691648078360767, "Malignant neoplasm progression ": 2.341822028937473, "Myelosuppression ": 98.16820857735608, "Neuropathy peripheral ": 6.868056683700585, "Neutropenia ": 8.98674136639577, "Neutrophil count decreased ": 46.5933605454822, "Platelet count decreased ": 24.203811143532118, "Red blood cell count decreased ": 15.814446673867652, "Renal impairment ": 2.069044047804484, "Thrombocytopenia ": 5.371263958732753, "White blood cell count decreased ": 32.39378602539339}
+{"Acute kidney injury": 6.895030961377874, "Cardiac failure": 15.078673608076889, "Dyspnoea": 2.085228787503045, "Syncope": 8.648516371117791}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1047.json

@@ -1 +1 @@
-{"Angioedema ": 4.852526923056708, "Blood creatinine increased ": 9.11414697954562, "Blood potassium increased ": 26.68296229833696, "Blood pressure inadequately controlled ": 143.43369787291007, "Blood pressure increased ": 8.85084234412658, "Cerebrovascular accident ": 2.6343060876584965, "Drug interaction ": 2.1225108539429067, "Hyperkalaemia ": 6.718978229010968, "Hypertension ": 4.070054403352931, "Palpitations ": 2.2555678102262497}
+{"Asthenia": 2.0297665972138086, "Cardiac failure": 2.1326734237511453, "Death": 6.644593702886772, "Disease progression": 2.428502090800721, "Dysphagia": 5.337199756249735, "General physical health deterioration": 2.256908028393501, "Hospitalisation": 3.607536407949742, "Hyperkeratosis": 31.339646439611634, "Hyperpyrexia": 16.748828454881412, "Malignant melanoma": 26.51803200313268, "Malignant neoplasm progression": 10.074603566996371, "Metastases to central nervous system": 35.97684734159338, "Metastases to lung": 10.738587887181808, "Metastatic malignant melanoma": 127.91629892137396, "Neutropenia": 2.0196736576082213, "Palmoplantar keratoderma": 337.1039155598279, "Product use in unapproved indication": 2.324539554268213, "Pyrexia": 3.2416631478560416, "Skin papilloma": 56.4605016308825, "Uveitis": 33.144610733618265}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1048.json

@@ -1 +1 @@
-{"Anaemia ": 20.976499490462054, "Blood creatinine increased ": 20.323346852892215, "Drug interaction ": 15.697916934734002, "Pruritus ": 2.5581591849985323, "Rash ": 5.4578924914558415, "Thrombocytopenia ": 4.147390809311243}
+{"Acne": 3.9817893001292526, "Acquired gene mutation": 14.86060427971434, "Aplastic anaemia": 2.4584023089024867, "Atelectasis": 2.37771660757051, "Blood creatine phosphokinase increased": 2.6123542299220905, "Blood sodium decreased": 2.0135075514031517, "Body height decreased": 4.185769001700461, "Brain neoplasm": 6.644883522038496, "Brain oedema": 3.1302435548088, "Carcinoembryonic antigen increased": 42.61673227311675, "Cardiac dysfunction": 12.327542922884517, "Cardiac failure": 8.52071036093018, "Cardiac failure acute": 5.251452961857661, "Cardiac failure chronic": 3.822153430360925, "Cardiac failure congestive": 2.507312373537516, "Cardiac tamponade": 5.463955370606241, "Cardiomyopathy": 5.997049806132496, "Cardiotoxicity": 4.967330641045299, "Cerebral infarction": 3.4034875300558856, "Conjunctivitis": 2.064826211216725, "Cutaneous vasculitis": 3.395635663936643, "Decreased appetite": 3.3204262462477563, "Deep vein thrombosis": 2.185114127131098, "Dermatitis": 3.8455674481922655, "Dermatitis acneiform": 23.26756462073814, "Diarrhoea": 3.4767849022646558, "Dilated cardiomyopathy": 3.147025142157053, "Disease progression": 2.480300105556443, "Drug eruption": 2.929434774742854, "Drug resistance": 4.47367629226466, "Dry eye": 2.448772686386256, "Dry skin": 9.05282648504712, "EGFR gene mutation": 44.62231329418593, "Ejection fraction decreased": 11.295137675058209, "Electrocardiogram QT prolonged": 14.629520935685772, "Erythema multiforme": 5.641609336630526, "Feeding disorder": 3.094787333093971, "Femur fracture": 2.416476449857122, "Fracture": 2.645747600499752, "Haematotoxicity": 2.965636279316429, "Haemoptysis": 2.417693027600344, "Heart failure with reduced ejection fraction": 28.31332695155776, "Hepatic function abnormal": 2.429688221568133, "Hypophagia": 2.2703870435921254, "Interstitial lung disease": 47.55755804580372, "Keratitis": 19.58168248049645, "Liver disorder": 3.2453349166959704, "Long QT syndrome": 15.736520794768186, "Lung disorder": 8.477348622658056, "Lung infiltration": 2.1073581419576777, "Lung neoplasm malignant": 8.157281600255411, "Lung opacity": 22.832835082362784, "Lymphangiosis carcinomatosa": 54.89363797859607, "Malignant neoplasm progression": 23.07686060217942, "Malignant pleural effusion": 16.791500949232315, "Metastases to bone": 16.023886140613364, "Metastases to central nervous system": 50.12358179331599, "Metastases to liver": 7.575937267365127, "Metastases to lung": 6.587186732999116, "Metastases to lymph nodes": 7.505266377899103, "Metastases to meninges": 80.14189619352831, "Metastases to pleura": 27.48685934398338, "Metastases to spine": 15.279311033087652, "Metastasis": 19.640796287052037, "Mouth ulceration": 2.0692533413201595, "Mucosal disorder": 6.642481227070001, "Mucosal inflammation": 3.283513389119108, "Myelosuppression": 2.6984300502336844, "Nail bed inflammation": 116.04007033133642, "Nail disorder": 27.50616212964865, "Neoplasm progression": 2.3573911721813654, "Neutrophil count decreased": 2.1104475114733785, "No adverse event": 2.7729909872459397, "Non-small cell lung cancer": 11.60562978054623, "Onychoclasis": 37.42974064973691, "Paronychia": 140.35659557675618, "Pericardial effusion": 3.709610246804262, "Platelet count decreased": 4.392614564417044, "Pleural effusion": 10.053933699554422, "Pneumocystis jirovecii pneumonia": 2.552700740824178, "Pneumonia aspiration": 2.26254680295525, "Pneumonia bacterial": 8.470957817758496, "Pneumonitis": 41.91260667605256, "Pneumothorax": 6.265809169077893, "Pulmonary alveolar haemorrhage": 4.041715289510191, "Pulmonary embolism": 3.061761150380486, "Pulmonary mass": 2.911086503171793, "Pulmonary oedema": 2.7454816572585274, "Pulmonary toxicity": 63.23391072785357, "Pustule": 2.946345586943139, "Rash": 2.3210180146443222, "Recurrent cancer": 10.40935008333442, "Respiratory failure": 2.934155550665392, "SARS-CoV-2 test negative": 12.007149456124772, "Skin disorder": 5.413889254239975, "Skin fissures": 16.32960554174431, "Skin toxicity": 7.815781450501984, "Skin ulcer": 2.032602812468616, "Small cell lung cancer": 21.49811021775693, "Stomatitis": 5.472740746696174, "Taste disorder": 3.310603632309159, "Thrombocytopenia": 3.954335554020756, "Torsade de pointes": 2.3862463935662435, "Tumour marker increased": 11.272312365499168}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1049.json

@@ -1 +1 @@
-{"Stevens-Johnson syndrome ": 235.45859548184885}
+{"Injection site pain": 2.943954252386543}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1051.json

@@ -1 +1 @@
-{"Acute kidney injury ": 3.794996012364297, "Angioedema ": 7.017530788545577, "Asthma ": 2.969908944251255, "Atrioventricular block complete ": 5.830511208547697, "Autonomic neuropathy ": 85.42130020171288, "Blood creatine phosphokinase increased ": 3.496464806514477, "Blood creatinine increased ": 2.3743380964573357, "Blood pressure abnormal ": 4.590611781376902, "Blood pressure decreased ": 3.3554718293230743, "Blood pressure fluctuation ": 3.6105456277226993, "Blood pressure inadequately controlled ": 42.25598979425666, "Blood pressure increased ": 3.3168886646528093, "Blood pressure systolic increased ": 3.729874266038971, "Blood urea increased ": 3.140265540239677, "Bradycardia ": 4.090960621042076, "Cardio-respiratory arrest ": 4.826456496855538, "Chest discomfort ": 3.2618584404812383, "Clostridium difficile infection ": 6.492767959112053, "Clumsiness ": 44.01255712891343, "Cognitive disorder ": 3.492785374209239, "Cough ": 2.746860519454692, "Cranial nerve disorder ": 95.0725410915532, "Drug interaction ": 2.823500108073976, "Drug level increased ": 2.8350645496234783, "Drug reaction with eosinophilia and systemic symptoms ": 2.4107711183112275, "Electrocardiogram abnormal ": 4.918461170090918, "Encephalopathy ": 3.8846470810827474, "Forced expiratory flow decreased ": 2804.388150094649, "Forced vital capacity decreased ": 311.63286284412646, "Full blood count abnormal ": 5.310903785908307, "Giant cell arteritis ": 34.0285107602632, "Heart rate decreased ": 5.281758681616276, "Hypercalcaemia ": 8.75568038213015, "Hyperkalaemia ": 10.287335806164004, "Hypertensive crisis ": 5.356696146564699, "Hypokalaemia ": 2.273463676710508, "Hyponatraemia ": 4.158363038635899, "Hypotension ": 3.092812003639183, "Illness ": 2.153865259770189, "Jaw disorder ": 47.529180325284045, "Left ventricular hypertrophy ": 12.13198423660111, "Loss of personal independence in daily activities ": 4.800037831736784, "Meningitis aseptic ": 12.6570295587455, "Mononeuropathy multiplex ": 120.48405403877672, "Myelitis ": 29.142288020288525, "Nasopharyngitis ": 4.014674871096902, "Oedema peripheral ": 3.0004241882566376, "Oligohydramnios ": 27.02468754792876, "Oliguria ": 5.370400027937494, "Optic neuropathy ": 42.39028228996898, "Oral discomfort ": 5.600585268935812, "Orthostatic hypotension ": 7.027951063427358, "Peripheral sensorimotor neuropathy ": 69.99693825383892, "Peripheral sensory neuropathy ": 15.417019349574757, "Product substitution issue ": 20.64133703091313, "Product use issue ": 3.771594390572568, "Prolonged expiration ": 84.50497864567333, "Proteinuria ": 2.89361043441058, "Pyelonephritis ": 6.255679723179492, "Red blood cell sedimentation rate increased ": 9.898958802959395, "Rhabdomyolysis ": 2.479783272090896, "SARS-CoV-2 test positive ": 3.7698750474433584, "Schizophrenia ": 6.0018915112044855, "Shock ": 3.060508605316859, "Sjogren's syndrome ": 26.32475250699679, "Sleep disorder due to a general medical condition ": 19.626837093032712, "Small fibre neuropathy ": 52.36215712988933, "Therapeutic product effect incomplete ": 5.949670181101318, "Thirst ": 2.6013816464191817, "Toxic epidermal necrolysis ": 2.0374826664606847, "Toxicity to various agents ": 2.565865072581975, "Wheezing ": 5.55756358154325}
+{"Acute kidney injury": 4.482919413466625, "Dermatitis acneiform": 109.56520027175364, "Diarrhoea": 3.910945204404408, "Drug interaction": 8.112214270459697, "International normalised ratio increased": 8.283980724673425, "Interstitial lung disease": 9.02994101022334, "Rash": 3.125658466136694}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1053.json

@@ -1 +1 @@
-{"Thrombocytopenia ": 34.07156698320266}
+{"Confusional state": 5.669563911778029, "Dyskinesia": 28.03310513943156}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1054.json

@@ -1 +1 @@
-{"Acute myeloid leukaemia ": 16.04641485252656, "Anaemia ": 2.21703539339331, "Aphasia ": 3.804293192407808, "Aplastic anaemia ": 42.15746161684291, "Astrocytoma ": 134.65670303122215, "Astrocytoma malignant ": 857.1310857801292, "Astrocytoma, low grade ": 470.633906066964, "Bone marrow failure ": 22.866841213880523, "Brain oedema ": 9.21045529819666, "Cholestasis ": 3.2985823658421487, "Cytopenia ": 4.797980290171688, "Dermatitis ": 3.529005135167269, "Diabetes insipidus ": 61.41906402176815, "Disease progression ": 16.15421356856522, "Disease recurrence ": 13.053283133201347, "Drug ineffective ": 2.21117844941391, "Drug reaction with eosinophilia and systemic symptoms ": 4.738067750484578, "Drug resistance ": 6.000159797207004, "Drug-induced liver injury ": 2.7360758674578536, "Eastern Cooperative Oncology Group performance status worsened ": 187.3886423931176, "Febrile neutropenia ": 5.276576310830276, "Glioblastoma ": 355.40828063677634, "Glioblastoma multiforme ": 250.3005974242701, "Haematotoxicity ": 55.01334121756218, "Hemiparesis ": 7.634211518217326, "Hepatic failure ": 2.3241201067759727, "Hepatotoxicity ": 3.594665722255572, "Hydrocephalus ": 16.113104648133792, "Hypermutation ": 3989.270212284088, "Hypertransaminasaemia ": 7.499914540658484, "Infection ": 2.4208713724480457, "Jaundice ": 2.7341669762548224, "Leukopenia ": 10.172920643292162, "Liver injury ": 2.825557141379093, "Lymphopenia ": 66.75238665159297, "Malignant neoplasm progression ": 9.587188952169704, "Metastasis ": 11.842009849091328, "Mucosal inflammation ": 3.8913693932643, "Myelodysplastic syndrome ": 32.27090725212073, "Myelosuppression ": 8.396614169605277, "Neoplasm progression ": 10.827016044707758, "Neutropenia ": 9.27793081950365, "Pancytopenia ": 20.55017296647523, "Petechiae ": 3.127501591806748, "Platelet count decreased ": 2.332553895473639, "Platelet transfusion ": 80.54199615150993, "Pneumocystis jirovecii pneumonia ": 17.669069548919932, "Product substitution issue ": 2.75563338050983, "Product use in unapproved indication ": 3.586037708834336, "Recurrent cancer ": 27.349213887157944, "Seizure ": 2.1612008364529225, "Sepsis ": 2.5116269997016007, "Skin reaction ": 3.122019542635341, "Therapeutic product effect incomplete ": 2.276155543131332, "Thrombocytopenia ": 26.29024978772875, "Toxicity to various agents ": 2.4373725895555034, "Treatment failure ": 2.35476778226406, "Tumour pseudoprogression ": 488.9504675403912, "Vanishing bile duct syndrome ": 133.89355413218908}
+{"Acute myeloid leukaemia": 24.392855630902638, "Agranulocytosis": 32.64999280948443, "Alopecia": 15.24131808896068, "Breast cancer": 2.3841679570405825, "Cardiac failure": 3.7044940923482015, "Diarrhoea": 2.6104567287426024, "Febrile bone marrow aplasia": 47.19696517020128, "Febrile neutropenia": 10.331509711212863, "Flushing": 3.3897819379479044, "Granulocytopenia": 10.186004229820725, "Hepatic function abnormal": 2.8702610770476173, "Interstitial lung disease": 8.553226188585219, "Leukopenia": 15.415440388408028, "Lung disorder": 2.001515387755858, "Malignant neoplasm progression": 2.4246877508444062, "Mucosal inflammation": 10.3136214171609, "Myelosuppression": 17.546431551703954, "Neuropathy peripheral": 2.272561801768008, "Neutropenia": 8.595250315089919, "Neutrophil count decreased": 13.76337197432074, "Oedema": 3.1204572923275715, "Palmar-plantar erythrodysaesthesia syndrome": 4.153081478533539, "Pancytopenia": 3.252733923666057, "Pleural effusion": 2.6175662514993405, "Pneumonitis": 3.392565185806798, "Prostatic specific antigen increased": 8.12737713949123, "Psychological trauma": 231.20972511778865, "Sepsis": 2.791674046342254, "Septic shock": 4.0061911267247465, "Skin exfoliation": 4.51448753622689, "Stomatitis": 9.298416330429918, "White blood cell count decreased": 15.763995605032802}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1055.json

@@ -1 +1 @@
-{"Anaemia ": 3.950644018200796, "Colitis ": 10.273485339860294, "Dehydration ": 4.06251538057722, "Disease progression ": 7.072765354782429, "Febrile neutropenia ": 29.09691853793297, "Hypertriglyceridaemia ": 37.08302601852363, "Interstitial lung disease ": 5.73365439118869, "Mucosal inflammation ": 15.267585899345825, "Myocardial infarction ": 4.519647519580414, "Neutropenia ": 7.260834303941766, "Neutrophil count decreased ": 6.668299049757854, "Overdose ": 4.736074388706919, "Pneumonia ": 3.099061957816612, "Pneumonitis ": 26.033960533213502, "Stomatitis ": 47.4149557735368, "Thrombocytopenia ": 2.715561165654413, "White blood cell count decreased ": 2.618507955041384}
+{"Balance disorder": 5.827939587163809, "Fall": 3.620177402181327, "Flushing": 13.435949972517502, "Gait disturbance": 3.11789893368362, "Gastrointestinal disorder": 2.970599946549323, "Memory impairment": 6.514345875131827, "Multiple sclerosis": 46.771396749336944, "Multiple sclerosis relapse": 48.757346912509696, "Muscle spasms": 3.784136065385861, "Muscle spasticity": 27.69113142670508, "Muscular weakness": 2.5932401840977333, "Urinary tract disorder": 83.19803877622537}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1056.json

@@ -1 +1 @@
-{"Acute kidney injury ": 5.417591513078398, "Alanine aminotransferase increased ": 4.80622794631563, "Aspartate aminotransferase increased ": 2.6535811939677347, "Blood alkaline phosphatase increased ": 2.867471441805755, "Blood bicarbonate decreased ": 55.16388215135517, "Blood creatine phosphokinase increased ": 4.284897958206766, "Blood creatinine increased ": 9.830290059793509, "Blood phosphorus decreased ": 85.43367228710261, "Blood urea increased ": 8.805888805590932, "Bone pain ": 4.274348497211423, "Chronic hepatitis B ": 389.0990288891209, "Chronic kidney disease ": 14.40170331232908, "Drug ineffective ": 2.027207051663556, "Drug resistance ": 12.66793728472928, "Drug-induced liver injury ": 2.310163478860713, "Fanconi syndrome ": 270.4801030760049, "Fanconi syndrome acquired ": 274.5703555001742, "Femur fracture ": 9.745262188288708, "Foetal exposure during pregnancy ": 3.4396858486596025, "Glomerular filtration rate decreased ": 26.25382620265648, "Glycosuria ": 208.0560519742387, "Hepatitis B ": 66.05944286504219, "Hepatitis B DNA increased ": 193.33614043315708, "Hepatitis B reactivation ": 90.9693594286036, "Hypokalaemia ": 4.552127168458829, "Hypophosphataemia ": 127.26828519478757, "Hypophosphataemic osteomalacia ": 846.721781779316, "Immune reconstitution inflammatory syndrome ": 12.867663194107063, "Lactic acidosis ": 3.481036080947576, "Maternal exposure during pregnancy ": 6.16179687642922, "Metabolic acidosis ": 15.265377300721712, "Multiple organ dysfunction syndrome ": 2.5388572546855173, "Nephrogenic diabetes insipidus ": 40.97437493593878, "Nephropathy toxic ": 36.3441495212082, "Osteomalacia ": 99.17814845409876, "Osteopenia ": 5.189291991228509, "Osteoporosis ": 8.634721512900589, "Proteinuria ": 24.1606279256998, "Rebound effect ": 118.93981745434986, "Renal failure ": 3.5900369824311653, "Renal impairment ": 13.01960026871292, "Renal tubular acidosis ": 160.38798791436352, "Renal tubular disorder ": 435.4851892212097, "Renal tubular dysfunction ": 371.5404758912924, "Renal tubular necrosis ": 22.580582914456304, "Treatment noncompliance ": 7.879381013301568, "Tubulointerstitial nephritis ": 5.814511798411333, "Viral load increased ": 51.89174899445597}
+{"Drug resistance": 254.29199408251824, "Off label use": 23.71985354584165}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1057.json

@@ -1 +1 @@
-{"Acute graft versus host disease ": 465.04008749833, "Graft versus host disease ": 383.9366784620941, "Mucosal inflammation ": 61.453650752156}
+{"Abdominal discomfort": 5.104824008091869, "Abdominal distension": 11.73864840142442, "Abdominal pain upper": 2.0946547610980635, "Anxiety": 2.421300950542125, "Apathy": 24.28397027051843, "Back pain": 3.809716613112885, "Balance disorder": 5.59142392900722, "Body temperature increased": 3.919760171494613, "Brain fog": 23.39382677643475, "Compression fracture": 119.30276811746002, "Contusion": 4.402898631708857, "Cough": 2.177310771427423, "Defaecation urgency": 132.1431431313278, "Depressed level of consciousness": 7.268014319753883, "Depression": 2.2393716335766176, "Eructation": 49.58185978617529, "Faeces hard": 249.298143700698, "Fall": 2.472132159958925, "Feeding disorder": 22.883103439136296, "Feeling abnormal": 5.343288421107279, "Flatulence": 24.34308121387681, "Frequent bowel movements": 42.62433073776352, "Gastrointestinal stoma complication": 827.8331164307498, "Gastrointestinal stoma output abnormal": 9535.860229578517, "Hiccups": 52.35140991832138, "Hot flush": 6.604050365706294, "Hypersomnia": 19.015954812781917, "Insomnia": 2.757819922179056, "Intestinal obstruction": 48.92497417169078, "Joint swelling": 4.873595929433718, "Lethargy": 5.576677379220881, "Lumbar vertebral fracture": 131.57213863050626}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1058.json

@@ -1 +1 @@
-{"Nausea ": 3.538019223047813}
+{"Abdominal pain": 2.595551872054118, "Fall": 4.650179772400432}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1059.json

@@ -1 +1 @@
-{"Alanine aminotransferase increased ": 2.27424550433732, "Alopecia ": 5.218457105556481, "Back pain ": 2.35408132758621, "Balance disorder ": 4.788713031039936, "Depressed mood ": 3.6773538294595913, "Fall ": 3.4592618735233875, "Gait disturbance ": 3.353421973267857, "Hepatic enzyme increased ": 3.7271520613998126, "Hypoaesthesia ": 3.1773718405128504, "Memory impairment ": 3.1825561538104483, "Multiple sclerosis ": 35.87273619557571, "Multiple sclerosis relapse ": 74.31171249524328, "Product substitution issue ": 14.914393889373814, "Unevaluable event ": 7.398559640031065, "Urinary tract infection ": 3.0511830535556634}
+{"Anaemia": 2.7779060769933666, "Cytopenia": 19.392637927828638, "Decreased appetite": 7.484064545801361, "Diarrhoea": 2.654596057841608, "Febrile neutropenia": 2.600021384872554, "Gastrointestinal disorder": 3.325434378516533, "Granulocyte count decreased": 35.40515316876338, "Haemoglobin decreased": 6.601374361586855, "Interstitial lung disease": 5.915587462163558, "Leukopenia": 9.690425588184556, "Malignant neoplasm progression": 2.341822028937473, "Myelosuppression": 98.16820857735608, "Neuropathy peripheral": 6.867848095559886, "Neutropenia": 8.98635464861954, "Neutrophil count decreased": 46.5933605454822, "Platelet count decreased": 24.203811143532118, "Red blood cell count decreased": 15.814446673867652, "Renal impairment": 2.069044047804484, "Thrombocytopenia": 5.370758502293885, "White blood cell count decreased": 32.39378602539339}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1060.json

@@ -1 +1 @@
-{"Back pain ": 3.2535292471658583, "Bone pain ": 4.1287137660365465, "Calciphylaxis ": 159.30080992833138, "Fall ": 5.765573187401218, "Femur fracture ": 16.10478800098519, "Hip fracture ": 15.484716274988267, "Hospitalisation ": 2.0386633959000635, "Hypercalcaemia ": 76.67013068304536, "Muscle spasms ": 2.469262203061878, "Nephrolithiasis ": 6.1441501362115165, "Renal impairment ": 2.354725013778273, "Skin necrosis ": 19.31323140631608, "Spinal compression fracture ": 18.35043349921976, "Spinal fracture ": 13.013928960845346, "Upper limb fracture ": 19.51463055554854}
+{"Angioedema": 4.852526923056708, "Blood creatinine increased": 9.11414697954562, "Blood potassium increased": 26.68296229833696, "Blood pressure inadequately controlled": 143.43369787291007, "Blood pressure increased": 8.850686979422518, "Cerebrovascular accident": 2.6342586219275974, "Drug interaction": 2.1225108539429067, "Hyperkalaemia": 6.718051989338982, "Hypertension": 4.070012386267104, "Palpitations": 2.2555678102262497}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1061.json

@@ -1 +1 @@
-{"Back pain ": 4.502696978429284, "Bone pain ": 6.888177846802693, "Device malfunction ": 17.42239485942071, "Dizziness ": 2.975380818238293, "Injection site bruising ": 42.52910538142604, "Injection site erythema ": 4.430756947462962, "Injection site haemorrhage ": 26.57497786214627, "Muscle spasms ": 3.495796094787281, "Nausea ": 2.087142972732305, "Pain in extremity ": 2.738348488732794, "Palpitations ": 3.018722676984012, "Product dose omission issue ": 5.198305610758029, "Therapy interrupted ": 62.73146371117658, "Wrong technique in device usage process ": 44.20027338226655}
+{"Anaemia": 20.976499490462054, "Blood creatinine increased": 20.323346852892215, "Drug interaction": 15.697916934734002, "Pruritus": 2.5581282005215877, "Rash": 5.457817515817974, "Thrombocytopenia": 4.147000690645847}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1062.json

@@ -1 +1 @@
-{"Accidental exposure to product ": 12.133928462726663, "Acne ": 9.482122962005262, "Acute myocardial infarction ": 17.65475484534197, "Aggression ": 4.5183831739044376, "Anger ": 5.4076833385033, "Angina pectoris ": 2.9020354193847595, "Aortic aneurysm ": 18.258745645855708, "Arteriosclerosis ": 10.723714771519749, "Atrial fibrillation ": 2.0124080333086325, "Blood testosterone decreased ": 86.29151750289886, "Blood testosterone increased ": 402.4808588251767, "Bone disorder ": 7.145259602703311, "Breast cancer ": 3.90925065961056, "Breast cancer metastatic ": 8.942166329506405, "Cardiac death ": 99.10206935253902, "Cardiac failure congestive ": 2.182295636042926, "Cardiomyopathy ": 7.394616815611124, "Cerebrovascular accident ": 4.358027315645759, "Cholestasis ": 3.115088246584666, "Coronary artery disease ": 11.698049165440857, "Coronary artery occlusion ": 6.878589948916703, "Deep vein thrombosis ": 15.49091109553344, "Device dislocation ": 34.210530559679896, "Device malfunction ": 6.05952459091586, "Drug abuse ": 12.984058523005102, "Drug-induced liver injury ": 2.5714357885909904, "Dyslipidaemia ": 9.428058377200806, "Endometrial cancer ": 45.82588833505356, "Erectile dysfunction ": 5.861588361794704, "Gynaecomastia ": 7.1351328836930366, "Hair growth abnormal ": 28.50880331471912, "Idiopathic intracranial hypertension ": 65.82142776256607, "Intentional product misuse ": 3.0541380412068246, "Invasive ductal breast carcinoma ": 17.47619105370686, "Jaundice ": 3.0896299929626605, "Left ventricular hypertrophy ": 46.62225786585368, "Libido decreased ": 7.07597971587408, "Mesenteric vein thrombosis ": 50.04406637958645, "Muscle mass ": 195.39051143952344, "Myocardial fibrosis ": 92.16453514520332, "Myocardial infarction ": 4.311761855990994, "Obstructive sleep apnoea syndrome ": 27.36125663288645, "Oestradiol increased ": 182.0430068416356, "Off label use ": 2.642928006776543, "Osteonecrosis ": 3.1980220199220595, "Papilloedema ": 18.204226209297303, "Polycythaemia ": 194.5021391228964, "Portal vein thrombosis ": 23.015678258440865, "Precocious puberty ": 180.70576479241248, "Prescription drug used without a prescription ": 22.69348618358044, "Product quality issue ": 13.9082561483666, "Product use in unapproved indication ": 2.8725928222521997, "Product use issue ": 7.260814834947145, "Prostate cancer ": 6.712579923483899, "Prostatic specific antigen increased ": 10.009669084425653, "Pulmonary embolism ": 8.985918267734501, "Self-medication ": 59.12310105212452, "Testicular atrophy ": 131.1330952288465, "Therapeutic product effect decreased ": 2.223839866377145, "Thrombosis ": 2.770689065908854, "Transgender hormonal therapy ": 3987.402969464821, "Virilism ": 929.6762637530966}
+{"Stevens-Johnson syndrome": 235.45859548184885}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1063.json

@@ -1 +1 @@
-{"Bone pain ": 27.846789229238368, "Drug ineffective ": 7.129563425841416, "Erythema ": 6.3232184249857255}
+{"Drug resistance": 148.29231174476035, "Therapeutic response decreased": 129.52114819956003}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1064.json

@@ -1 +1 @@
-{"Product use in unapproved indication ": 20.18888135059103}
+{"Acute kidney injury": 3.794996012364297, "Angioedema": 7.017530788545577, "Asthma": 2.969908944251255, "Atrioventricular block complete": 5.830511208547697, "Autonomic neuropathy": 85.42130020171288, "Blood creatine phosphokinase increased": 3.496464806514477, "Blood creatinine increased": 2.3743380964573357, "Blood pressure abnormal": 4.590611781376902, "Blood pressure decreased": 3.355362847262481, "Blood pressure fluctuation": 3.6105456277226993, "Blood pressure inadequately controlled": 42.25598979425666, "Blood pressure increased": 3.3168304021918025, "Blood pressure systolic increased": 3.729874266038971, "Blood urea increased": 3.140265540239677, "Bradycardia": 4.090832288773228, "Cardio-respiratory arrest": 4.826456496855538, "Chest discomfort": 3.261743866805755, "Clostridium difficile infection": 6.492767959112053, "Clumsiness": 44.01255712891343, "Cognitive disorder": 3.492785374209239, "Cough": 2.746835024175105, "Cranial nerve disorder": 95.0725410915532, "Drug interaction": 2.823500108073976, "Drug level increased": 2.8350645496234783, "Drug reaction with eosinophilia and systemic symptoms": 2.4105719907855825, "Electrocardiogram abnormal": 4.918461170090918, "Encephalopathy": 3.8846470810827474, "Forced expiratory flow decreased": 2804.388150094649, "Forced vital capacity decreased": 311.63286284412646, "Full blood count abnormal": 5.310903785908307, "Giant cell arteritis": 34.0285107602632, "Heart rate decreased": 5.281758681616276, "Hypercalcaemia": 8.75568038213015, "Hyperkalaemia": 10.28591351165527, "Hypertensive crisis": 5.356696146564699, "Hypokalaemia": 2.273463676710508, "Hyponatraemia": 4.158363038635899, "Hypotension": 3.0927404476302844, "Illness": 2.153865259770189, "Jaw disorder": 47.529180325284045, "Left ventricular hypertrophy": 12.13198423660111, "Loss of personal independence in daily activities": 4.800037831736784, "Meningitis aseptic": 12.6570295587455, "Mononeuropathy multiplex": 120.48405403877672, "Myelitis": 29.142288020288525, "Nasopharyngitis": 4.014368683866509, "Oedema peripheral": 3.000349987672477, "Oligohydramnios": 27.02468754792876, "Oliguria": 5.370400027937494, "Optic neuropathy": 42.39028228996898, "Oral discomfort": 5.600585268935812, "Orthostatic hypotension": 7.026435944865429, "Peripheral sensorimotor neuropathy": 69.99693825383892, "Peripheral sensory neuropathy": 15.417019349574757, "Product substitution issue": 20.64133703091313, "Product use issue": 3.771594390572568, "Prolonged expiration": 84.50497864567333, "Proteinuria": 2.89361043441058, "Pyelonephritis": 6.255679723179492, "Red blood cell sedimentation rate increased": 9.898958802959395, "Rhabdomyolysis": 2.479783272090896, "SARS-CoV-2 test positive": 3.7698750474433584, "Schizophrenia": 6.0018915112044855, "Shock": 3.060508605316859, "Sjogren's syndrome": 26.32475250699679, "Sleep disorder due to a general medical condition": 19.626837093032712, "Small fibre neuropathy": 52.36215712988933, "Therapeutic product effect incomplete": 5.949670181101318, "Thirst": 2.6013816464191817, "Toxic epidermal necrolysis": 2.0374826664606847, "Toxicity to various agents": 2.565865072581975, "Wheezing": 5.55734223598461}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1065.json

@@ -1 +1 @@
-{"Asthma ": 32.77069085038518}
+{"Accidental overdose": 2.021944068519444, "Acute myeloid leukaemia": 4.697469622613545, "Adverse event": 5.159673582685695, "Agranulocytosis": 6.890720876523194, "Anaemia": 2.993281424593362, "Aphasia": 2.679084608244679, "Aplastic anaemia": 15.6668334258515, "Bone marrow failure": 75.58261547778442, "Brain oedema": 14.227845757049147, "Cerebral haemorrhage": 3.0396994652250915, "Cholestasis": 10.19912620418355, "Congenital aplasia": 35.24216535614194, "Cytomegalovirus infection": 3.53531543677993, "Cytopenia": 6.188900948772196, "Death": 2.3222845907838314, "Disease progression": 14.26524598055019, "Disseminated intravascular coagulation": 4.194103887785389, "Drug eruption": 4.608319039707278, "Dysphagia": 3.6091554354653006, "Eastern Cooperative Oncology Group performance status worsened": 65.30374806141688, "Eosinophilia": 2.084203745807542, "Epilepsy": 2.5343123483670507, "Erythema multiforme": 2.18331725783742, "Febrile bone marrow aplasia": 61.711446118932976, "Febrile neutropenia": 4.228854622574868, "Gamma-glutamyltransferase increased": 3.189726350476666, "Gingival bleeding": 2.848373774378412, "Glioblastoma": 117.97095157262052, "Glioblastoma multiforme": 115.2803270972064, "Haematotoxicity": 6.993518151542569, "Haemolytic anaemia": 3.464307995711492, "Haemorrhage intracranial": 2.6301496434181058, "Hemiparesis": 4.2270607926352834, "Hemiplegia": 7.007870727675664, "Hepatic cytolysis": 11.070975910716482, "Hepatic function abnormal": 4.41479338813716, "Hepatocellular injury": 6.298118991076426, "Hepatotoxicity": 3.1233405925009, "Interstitial lung disease": 2.0377330514662835, "Intracranial pressure increased": 8.988180294232402, "Intracranial tumour haemorrhage": 190.7489374680354, "Jaundice": 2.0581519060457216, "Leukoencephalopathy": 12.398851522272532, "Leukopenia": 13.303415553079107, "Liver disorder": 2.0097685927862594, "Liver injury": 2.0615874713278037, "Lymphocyte count decreased": 23.094458699195787, "Lymphopenia": 16.674801654465757, "Malignant neoplasm progression": 3.857710699635272, "Mucosal inflammation": 2.4011345527312358, "Multiple organ dysfunction syndrome": 2.082849472234703, "Myelodysplastic syndrome": 6.27015846392321, "Myelosuppression": 8.261112096626821, "Neoplasm progression": 3.231750117357893, "Neutropenia": 8.200406187995402, "Neutrophil count decreased": 3.684202822636038, "Pancytopenia": 30.67959178025011, "Petechiae": 4.815179466232132, "Platelet count decreased": 6.737346898345562, "Platelet transfusion": 56.856190435632094, "Pneumocystis jirovecii infection": 54.99866947203114, "Pneumocystis jirovecii pneumonia": 30.49218608333081, "Pneumonia": 2.4978529532977016, "Pneumonia aspiration": 2.516245893760322, "Pulmonary embolism": 3.933902126670397, "Purpura": 4.5105509531288135, "Rash maculo-papular": 2.786022985223884, "Recurrent cancer": 24.547397118912546, "Seizure": 2.105077562087981, "Sepsis": 6.073810292992525, "Septic shock": 2.19057012296935, "Stevens-Johnson syndrome": 7.507667580523036, "Surgery": 2.4341280729344525, "Thrombocytopenia": 22.970093691845168, "Toxic epidermal necrolysis": 4.94899784780584, "Toxic skin eruption": 5.325183131055749, "White blood cell count decreased": 4.697841444563848}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1066.json

@@ -1 +1 @@
-{"Acute lymphocytic leukaemia ": 15.812596111587196, "Acute myeloid leukaemia ": 5.498676222119293, "Acute myocardial infarction ": 2.51947590093894, "Atelectasis ": 5.550066240676565, "Bone disorder ": 4.40870021513675, "Bone lesion ": 21.1461499036955, "Bradycardia ": 4.76426431671323, "Cardiac failure ": 2.8866464699666, "Constipation ": 4.409454140698935, "Cutaneous vasculitis ": 5.137814944953071, "Cytopenia ": 3.3614996845067195, "Death ": 3.432036286069746, "Deep vein thrombosis ": 12.461071063351248, "Disease progression ": 5.423874211474828, "Disorientation ": 2.00625300028967, "Drug intolerance ": 2.168788886952251, "Drug reaction with eosinophilia and systemic symptoms ": 5.232508679075661, "Dysaesthesia ": 4.974378184157472, "Embolism ": 9.526398187641204, "Febrile neutropenia ": 3.443644831636957, "Infection ": 2.6350909874578123, "Myelodysplastic syndrome ": 6.728775349883188, "Neuropathy peripheral ": 36.88539939712409, "Neurotoxicity ": 4.854351083876428, "Neutropenia ": 2.935765394524316, "Oedema ": 2.486531273173087, "Oedema peripheral ": 3.145178411541293, "Orthostatic hypotension ": 3.313992552935185, "Osteonecrosis of jaw ": 12.31537943769507, "Pancytopenia ": 4.191613805125339, "Paraesthesia ": 2.4860527681080287, "Peripheral motor neuropathy ": 68.0896975870547, "Peripheral sensory neuropathy ": 86.03693107542922, "Plasma cell myeloma ": 49.61178118538482, "Plasma cell myeloma recurrent ": 46.55714078620445, "Plasmacytoma ": 74.41602336223518, "Pneumonia ": 2.0727183197664885, "Pneumonitis ": 2.956133445462064, "Polyneuropathy ": 23.35385164384917, "Pulmonary embolism ": 8.641650065482954, "Pulmonary hypertension ": 2.786863653378804, "Rash maculo-papular ": 3.2109750819015503, "Renal impairment ": 2.2589405225942327, "Sepsis ": 4.265431141318596, "Septic shock ": 2.9667337358143904, "Sinus bradycardia ": 4.420869636439437, "Therapy non-responder ": 9.953902823222815, "Toxic skin eruption ": 3.851538552788668, "Transient ischaemic attack ": 2.8797802067650737, "Tumour lysis syndrome ": 8.188848339258541, "Type 2 lepra reaction ": 200.82207246801983, "Varicella zoster virus infection ": 25.852618001457504, "Venous thrombosis limb ": 11.007824549815108}
+{"Thrombocytopenia": 34.068362137670974}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1067.json

@@ -1 +1 @@
-{"Acute lymphocytic leukaemia ": 200.72756871358172, "Decreased appetite ": 4.975512483857825, "Febrile neutropenia ": 17.563989664438253, "Leukopenia ": 10.748193567293193, "Mucosal inflammation ": 27.58822158590593, "Myelosuppression ": 6.927597858062939, "Stomatitis ": 13.94546001504778, "Vomiting ": 2.306500115656245}
+{"Acute myeloid leukaemia": 16.04641485252656, "Anaemia": 2.21703539339331, "Aphasia": 3.803726376746415, "Aplastic anaemia": 42.15746161684291, "Astrocytoma": 134.65670303122215, "Astrocytoma malignant": 857.1310857801292, "Astrocytoma, low grade": 470.633906066964, "Bone marrow failure": 22.866841213880523, "Brain oedema": 9.21045529819666, "Cholestasis": 3.2985823658421487, "Cytopenia": 4.79416271297974, "Dermatitis": 3.528543307937692, "Diabetes insipidus": 61.41906402176815, "Disease progression": 16.15421356856522, "Disease recurrence": 13.053283133201347, "Drug ineffective": 2.211162095761864, "Drug reaction with eosinophilia and systemic symptoms": 4.737676161759718, "Drug resistance": 6.000159797207004, "Drug-induced liver injury": 2.7359090555583907, "Eastern Cooperative Oncology Group performance status worsened": 187.3886423931176, "Febrile neutropenia": 5.276576310830276, "Glioblastoma": 355.40828063677634, "Glioblastoma multiforme": 250.3005974242701, "Haematotoxicity": 55.01334121756218, "Hemiparesis": 7.633248053251657, "Hepatic failure": 2.3241201067759727, "Hepatotoxicity": 3.594665722255572, "Hydrocephalus": 16.113104648133792, "Hypermutation": 3989.270212284088, "Hypertransaminasaemia": 7.499914540658484, "Infection": 2.4208713724480457, "Jaundice": 2.7341669762548224, "Leukopenia": 10.17163516166689, "Liver injury": 2.825557141379093, "Lymphopenia": 66.75238665159297, "Malignant neoplasm progression": 9.587188952169704, "Metastasis": 11.842009849091328, "Mucosal inflammation": 3.8913693932643, "Myelodysplastic syndrome": 32.27090725212073, "Myelosuppression": 8.396614169605277, "Neoplasm progression": 10.827016044707758, "Neutropenia": 9.277530940996504, "Pancytopenia": 20.55017296647523, "Petechiae": 3.127501591806748, "Platelet count decreased": 2.332553895473639, "Platelet transfusion": 80.54199615150993, "Pneumocystis jirovecii pneumonia": 17.669069548919932, "Product substitution issue": 2.75563338050983, "Product use in unapproved indication": 3.5859257910295024, "Recurrent cancer": 27.349213887157944, "Seizure": 2.1609611552650967, "Sepsis": 2.5116269997016007, "Skin reaction": 3.122019542635341, "Therapeutic product effect incomplete": 2.276155543131332, "Thrombocytopenia": 26.28776013175121, "Toxicity to various agents": 2.4373725895555034, "Treatment failure": 2.35476778226406, "Tumour pseudoprogression": 488.9504675403912, "Vanishing bile duct syndrome": 133.89355413218908}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1068.json

@@ -1 +1 @@
-{}
+{"Anaemia": 3.950644018200796, "Colitis": 10.273485339860294, "Dehydration": 4.062298553578651, "Disease progression": 7.072765354782429, "Febrile neutropenia": 29.09691853793297, "Hypertriglyceridaemia": 37.08302601852363, "Interstitial lung disease": 5.73365439118869, "Mucosal inflammation": 15.267585899345825, "Myocardial infarction": 4.519647519580414, "Neutropenia": 7.260522026211707, "Neutrophil count decreased": 6.668299049757854, "Overdose": 4.736074388706919, "Pneumonia": 3.099061957816612, "Pneumonitis": 26.033960533213502, "Stomatitis": 47.4149557735368, "Thrombocytopenia": 2.715305727058652, "White blood cell count decreased": 2.618507955041384}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1069.json

@@ -1 +1 @@
-{"Acute graft versus host disease ": 40.98962384468704, "Acute graft versus host disease in intestine ": 162.54282149464166, "Acute graft versus host disease in skin ": 191.7586418440809, "Acute promyelocytic leukaemia ": 80.76217224837043, "Acute respiratory distress syndrome ": 17.10351741163306, "Adenovirus infection ": 53.87190121599772, "Anaemia ": 4.726986018840199, "Aplastic anaemia ": 16.247896771933043, "Chronic graft versus host disease ": 39.84050064061359, "Chronic graft versus host disease in skin ": 192.51735717586604, "Cystitis haemorrhagic ": 41.35647694111013, "Cytomegalovirus infection reactivation ": 80.80282490665593, "Deafness ": 18.3052108148416, "Febrile neutropenia ": 20.523005794198767, "Focal nodular hyperplasia ": 679.6024211412794, "Graft versus host disease in gastrointestinal tract ": 177.81909816834084, "Graft versus host disease in skin ": 66.86096760754364, "Haematotoxicity ": 34.0783825233434, "Hepatotoxicity ": 15.106087171396371, "Leukopenia ": 2.96137769703598, "Medulloblastoma recurrent ": 2815.918222338205, "Mucosal inflammation ": 62.6153191884963, "Multiple organ dysfunction syndrome ": 4.057598456527057, "Myelodysplastic syndrome ": 13.236047168380043, "Myelosuppression ": 4.700370594290437, "Nervous system disorder ": 14.202169728341207, "Neurotoxicity ": 10.093362038127054, "Neutropenia ": 14.35940609681729, "Off label use ": 3.176041839849927, "Osteosarcoma ": 502.9693174763792, "Pancytopenia ": 2.3438655669244155, "Platelet count decreased ": 2.7444765210459163, "Pneumonia cytomegaloviral ": 65.051301155106, "Product use in unapproved indication ": 5.141231068359846, "Pulmonary arterial hypertension ": 17.042966491558634, "Respiratory distress ": 3.198589154126713, "Second primary malignancy ": 28.662096829500527, "Sepsis ": 5.875374627324435, "Short stature ": 605.5471836042957, "Stomatitis ": 5.199218308356958, "Thrombocytopenia ": 13.79268024687211, "Thrombotic microangiopathy ": 28.27481572516789, "Venoocclusive liver disease ": 49.76301641465533, "Visual impairment ": 6.677342690487749}
+{"Acute kidney injury": 5.417591513078398, "Alanine aminotransferase increased": 4.80622794631563, "Aspartate aminotransferase increased": 2.6535811939677347, "Blood alkaline phosphatase increased": 2.867471441805755, "Blood bicarbonate decreased": 55.16388215135517, "Blood creatine phosphokinase increased": 4.284897958206766, "Blood creatinine increased": 9.830290059793509, "Blood phosphorus decreased": 85.43367228710261, "Blood urea increased": 8.805888805590932, "Bone pain": 4.274348497211423, "Chronic hepatitis B": 389.0990288891209, "Chronic kidney disease": 14.40086325493597, "Drug ineffective": 2.027192062887665, "Drug resistance": 12.66793728472928, "Drug-induced liver injury": 2.310022693378381, "Fanconi syndrome": 270.4801030760049, "Fanconi syndrome acquired": 274.5703555001742, "Femur fracture": 9.745262188288708, "Foetal exposure during pregnancy": 3.4396858486596025, "Glomerular filtration rate decreased": 26.25382620265648, "Glycosuria": 208.0560519742387, "Hepatitis B": 66.05944286504219, "Hepatitis B DNA increased": 193.33614043315708, "Hepatitis B reactivation": 90.9693594286036, "Hypokalaemia": 4.552127168458829, "Hypophosphataemia": 127.26828519478757, "Hypophosphataemic osteomalacia": 846.721781779316, "Immune reconstitution inflammatory syndrome": 12.867663194107063, "Lactic acidosis": 3.481036080947576, "Maternal exposure during pregnancy": 6.16179687642922, "Metabolic acidosis": 15.265377300721712, "Multiple organ dysfunction syndrome": 2.5388572546855173, "Nephrogenic diabetes insipidus": 40.97437493593878, "Nephropathy toxic": 36.3441495212082, "Osteomalacia": 99.17814845409876, "Osteopenia": 5.189291991228509, "Osteoporosis": 8.634721512900589, "Proteinuria": 24.1606279256998, "Rebound effect": 118.93981745434986, "Renal failure": 3.5900369824311653, "Renal impairment": 13.01960026871292, "Renal tubular acidosis": 160.38798791436352, "Renal tubular disorder": 435.4851892212097, "Renal tubular dysfunction": 371.5404758912924, "Renal tubular necrosis": 22.580582914456304, "Treatment noncompliance": 7.879381013301568, "Tubulointerstitial nephritis": 5.814511798411333, "Viral load increased": 51.89174899445597}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1070.json

@@ -1 +1 @@
-{"Abortion spontaneous ": 227.04082780582536, "Maternal exposure during pregnancy ": 96.34696146561234}
+{"Acute graft versus host disease": 465.04008749833, "Graft versus host disease": 383.9366784620941, "Mucosal inflammation": 61.453650752156}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1071.json

@@ -1 +1 @@
-{"Acute coronary syndrome ": 4.833472647267703, "Acute kidney injury ": 2.468818293486269, "Acute myocardial infarction ": 8.448810431637515, "Amaurosis ": 39.52333191306073, "Angina unstable ": 5.615154263583051, "Asphyxia ": 37.63570374965063, "Atrioventricular block ": 5.77635850162484, "Atrioventricular block complete ": 6.731418726769471, "Blood loss anaemia ": 50.74725054408197, "Bronchial haemorrhage ": 95.99923570525895, "Cardiogenic shock ": 3.040671287583894, "Cerebral haemorrhage ": 7.171756197195853, "Chest discomfort ": 9.460401999354136, "Chronic gastritis ": 48.18818488575063, "Conjunctival haemorrhage ": 10.210196166291176, "Coronary artery occlusion ": 6.677786758875344, "Coronary artery stenosis ": 15.183550255424525, "Diarrhoea haemorrhagic ": 10.417887976840806, "Drug interaction ": 4.957388398314164, "Duodenal ulcer ": 15.889728071557718, "Duodenal ulcer haemorrhage ": 32.86101281959504, "Dyspnoea ": 4.729598761683767, "Dyspnoea at rest ": 16.622340433961543, "Ecchymosis ": 19.24954589386545, "Electrocardiogram ST segment elevation ": 6.6434971709886135, "Epistaxis ": 6.616247987252902, "Eye haemorrhage ": 2.471622456330378, "Faeces discoloured ": 16.77884091353526, "Gastric haemorrhage ": 9.73669946209261, "Gastric mucosal lesion ": 67.19114694267986, "Gastric ulcer ": 7.5418794805671965, "Gastric ulcer haemorrhage ": 20.12180399203093, "Gastritis erosive ": 18.46889262153336, "Gastrointestinal haemorrhage ": 26.04518349788933, "Gingival bleeding ": 14.890783877736542, "Gout ": 5.717688853474336, "Haematemesis ": 32.75904461306297, "Haematochezia ": 17.490500659589728, "Haematoma ": 3.075330957252272, "Haematuria ": 9.169292620862317, "Haemoglobin decreased ": 6.542218569003436, "Haemoptysis ": 11.78474493545197, "Haemorrhage ": 3.423993774908652, "Haemorrhage intracranial ": 12.488215838481278, "Haemorrhage subcutaneous ": 28.148778203318603, "Haemorrhage urinary tract ": 13.819169447400435, "Haemorrhoidal haemorrhage ": 10.6583566207891, "Haemothorax ": 11.45930800695112, "Incorrect dose administered ": 2.1559789812340373, "Iron deficiency anaemia ": 4.469980941847617, "Labelled drug-drug interaction issue ": 220.60996919041324, "Labelled drug-drug interaction medication error ": 199.4374895009144, "Lower gastrointestinal haemorrhage ": 62.99539964068568, "Melaena ": 59.43854388157198, "Myopathy ": 4.604628449945429, "Occult blood positive ": 35.740598372901744, "Pericardial haemorrhage ": 16.089366722855882, "Platelet aggregation inhibition ": 471.91629779597486, "Post procedural haemorrhage ": 5.864217060738054, "Product administration error ": 3.3964352939835822, "Product prescribing issue ": 28.85639652403592, "Pulmonary alveolar haemorrhage ": 14.28467889812784, "Pulmonary haemorrhage ": 14.73140373657302, "Purpura ": 2.5606403193661684, "Rectal haemorrhage ": 4.633215208097326, "Respiratory rate increased ": 6.941773923038289, "Respiratory tract haemorrhage ": 38.35344174403821, "Rhabdomyolysis ": 12.100416845817044, "Shock haemorrhagic ": 8.554998460301464, "Sinus arrest ": 44.90060240060416, "Subarachnoid haemorrhage ": 11.808347174243016, "Subdural haematoma ": 4.562433482018913, "Tachypnoea ": 8.387425090653139, "Thrombotic thrombocytopenic purpura ": 6.361380751466973, "Treatment noncompliance ": 2.6151451612268586, "Upper gastrointestinal haemorrhage ": 123.53121169706012, "Vascular stent thrombosis ": 30.77366095198895, "Ventricular asystole ": 129.26035004649873}
+{"Nausea": 3.5380030778930496}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1072.json

@@ -1 +1 @@
-{"Acinetobacter infection ": 279.0412634880268, "Acute respiratory distress syndrome ": 22.622277115187547, "Bacteraemia ": 36.50545089236813, "Blood bilirubin increased ": 5.640249190247344, "Coagulopathy ": 13.385699435208718, "Condition aggravated ": 4.308569571404217, "Drug ineffective ": 6.491071222586458, "Drug resistance ": 27.81282443104805, "Electrocardiogram QT prolonged ": 4.713881439747022, "Hepatic function abnormal ": 6.831461780872209, "Klebsiella infection ": 173.65006107216314, "Liver function test abnormal ": 10.803848506217888, "Liver injury ": 10.461446568340955, "Mental status changes ": 13.065675539197924, "Off label use ": 3.912522559215336, "Pancreatitis acute ": 7.469700010507458, "Pathogen resistance ": 136.85464308207028, "Platelet count decreased ": 3.361274845497193, "Product use issue ": 3.2802729536254747, "Pseudomembranous colitis ": 42.06122203494714, "Sepsis ": 4.96673712352168, "Septic shock ": 8.16353936224208, "Thrombocytopenia ": 2.622345071050122, "Tinnitus ": 3.817653691905613}
+{"Alanine aminotransferase increased": 2.27424550433732, "Alopecia": 5.218457105556481, "Back pain": 2.35408132758621, "Balance disorder": 4.788713031039936, "Depressed mood": 3.6773538294595913, "Fall": 3.459173184360765, "Gait disturbance": 3.3533611742158804, "Hepatic enzyme increased": 3.7271520613998126, "Hypoaesthesia": 3.1773718405128504, "Memory impairment": 3.1825561538104483, "Multiple sclerosis": 35.87273619557571, "Multiple sclerosis relapse": 74.31171249524328, "Product substitution issue": 14.914393889373814, "Unevaluable event": 7.398559640031065, "Urinary tract infection": 3.0511830535556634}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1073.json

@@ -1 +1 @@
-{"Arrhythmia ": 7.027505058064821, "Atrial fibrillation ": 24.69335469179725, "Drug interaction ": 5.800276807716031, "Electrocardiogram QT prolonged ": 10.489360458467567, "Heart rate decreased ": 14.197114362627648, "Heart rate increased ": 6.239990256040112, "Visual impairment ": 3.519889071561064}
+{"Back pain": 3.2535292471658583, "Bone pain": 4.1287137660365465, "Calciphylaxis": 159.30080992833138, "Fall": 5.765425314138002, "Femur fracture": 16.10478800098519, "Hip fracture": 15.484716274988267, "Hospitalisation": 2.0386633959000635, "Hypercalcaemia": 76.67013068304536, "Muscle spasms": 2.469262203061878, "Nephrolithiasis": 6.143134211067866, "Renal impairment": 2.354725013778273, "Skin necrosis": 19.31323140631608, "Spinal compression fracture": 18.35043349921976, "Spinal fracture": 13.013928960845346, "Upper limb fracture": 19.51463055554854}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1074.json

@@ -1 +1 @@
-{"Acute kidney injury ": 6.690969155934481, "Acute lymphocytic leukaemia recurrent ": 213.7602463923735, "Cytokine release syndrome ": 372.884739585333, "Diffuse large B-cell lymphoma ": 116.7143615763726, "Disease progression ": 5.537481926080544, "Disseminated intravascular coagulation ": 38.38684237003344, "Encephalopathy ": 28.856036376113, "Febrile neutropenia ": 13.811249080970205, "Haemophagocytic lymphohistiocytosis ": 61.20934212873309, "Hypotension ": 4.229529676385023, "Hypoxia ": 17.688184690083133, "Immune effector cell-associated neurotoxicity syndrome ": 378.3965970313274, "Lymphopenia ": 75.03930993327171, "Malignant neoplasm progression ": 2.229553208403124, "Neurotoxicity ": 33.45867697076864, "Neutropenia ": 3.2785808705731547, "Neutrophil count decreased ": 22.27787845533811, "Platelet count decreased ": 5.951540828268608, "Sepsis ": 4.639928608539302, "Tumour lysis syndrome ": 45.50688407212719, "White blood cell count decreased ": 12.273883794568777}
+{"Back pain": 4.502696978429284, "Bone pain": 6.888177846802693, "Device malfunction": 17.42239485942071, "Dizziness": 2.975360160046048, "Injection site bruising": 42.52910538142604, "Injection site erythema": 4.430756947462962, "Injection site haemorrhage": 26.57497786214627, "Muscle spasms": 3.495796094787281, "Nausea": 2.087133447193419, "Pain in extremity": 2.7383340065924853, "Palpitations": 3.018722676984012, "Product dose omission issue": 5.198305610758029, "Therapy interrupted": 62.73146371117658, "Wrong technique in device usage process": 44.20027338226655}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1075.json

@@ -1 +1 @@
-{"Myelosuppression ": 150.64707793241547, "Neutrophil count decreased ": 47.262203783402434, "Off label use ": 2.4125997107597814, "Platelet count decreased ": 25.45588638138306, "White blood cell count decreased ": 40.15888725408857}
+{"Accidental exposure to product": 12.080499856820271, "Acne": 9.440369199313349, "Acute myocardial infarction": 17.576976517201253, "Aggression": 4.498486436025834, "Anger": 5.383876922768514, "Angina pectoris": 2.889259044182473, "Aortic aneurysm": 18.17837141989954, "Arteriosclerosis": 10.676505452687696, "Atrial fibrillation": 2.0034923906712687, "Blood testosterone decreased": 85.91153653197748, "Blood testosterone increased": 412.3866340747055, "Bone disorder": 7.113804647529053, "Breast cancer": 3.892036576317762, "Breast cancer metastatic": 8.902801016524183, "Cardiac death": 98.66579407767033, "Cardiac failure congestive": 2.172523167707363, "Cardiomyopathy": 7.362062427575814, "Cerebrovascular accident": 4.418975651837623, "Cholestasis": 3.101375735972487, "Coronary artery disease": 11.646528459185175, "Coronary artery occlusion": 6.848311564568541, "Deep vein thrombosis": 15.422624290547953, "Device dislocation": 34.05992900066411, "Device malfunction": 6.032849269129476, "Drug abuse": 12.926828588353708, "Drug-induced liver injury": 2.559959420775908, "Dyslipidaemia": 9.386557677931464, "Endometrial cancer": 45.62416534941225, "Erectile dysfunction": 5.835781165615611, "Gynaecomastia": 7.10372429034173, "Hair growth abnormal": 28.38329845833128, "Idiopathic intracranial hypertension": 65.5316144352414, "Intentional product misuse": 3.0406896463845103, "Invasive ductal breast carcinoma": 17.39926159304209, "Jaundice": 3.0760270732134494, "Left ventricular hypertrophy": 46.41696567317301, "Libido decreased": 7.04483245600222, "Mesenteric vein thrombosis": 49.82377531698251, "Muscle mass": 194.53045341531097, "Myocardial fibrosis": 91.75883416578648, "Myocardial infarction": 4.292764777491754, "Obstructive sleep apnoea syndrome": 27.240806841862785, "Oestradiol increased": 181.24167592430973, "Off label use": 2.683094544723802, "Osteonecrosis": 3.183937228998872, "Papilloedema": 18.124087432693496, "Polycythaemia": 193.6453657717842, "Portal vein thrombosis": 22.914358530816408, "Precocious puberty": 179.91027558289872, "Prescription drug used without a prescription": 22.59359349114965, "Product quality issue": 13.846996295569904, "Product use in unapproved indication": 2.859849532029431, "Product use issue": 7.471237596419519, "Prostate cancer": 6.6830260146961855, "Prostatic specific antigen increased": 9.965604403503, "Pulmonary embolism": 9.053819098044029, "Self-medication": 58.86283737018609, "Testicular atrophy": 130.55584368399477, "Therapeutic product effect decreased": 2.214050043694165, "Thrombosis": 2.8968926194906124, "Transgender hormonal therapy": 3969.856152227744, "Virilism": 925.5841314939246}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1076.json

@@ -1 +1 @@
-{"Abnormal dreams ": 7.369999789464062, "Amnesia ": 2.595667529497314, "Blood HIV RNA increased ": 113.2947565518387, "Blood calcium increased ": 10.782368581468528, "Blood creatine phosphokinase increased ": 3.699981670724645, "Blood creatinine increased ": 4.0523572205468845, "Cholestasis ": 2.9158428083437973, "Deafness ": 2.841806514409853, "Depressed mood ": 3.033685811126822, "Depression ": 2.839720441796729, "Dermatitis ": 4.247386074521855, "Drug resistance ": 3.075588478323166, "Dysuria ": 3.0409831746805933, "Glomerular filtration rate decreased ": 4.202684904602609, "Hepatic cytolysis ": 2.5171205234106626, "Hepatic failure ": 2.2570005405403166, "Hepatitis ": 4.701953903118595, "Hospitalisation ": 3.4045985499987865, "Hyperlipidaemia ": 6.78991836222758, "Immune reconstitution inflammatory syndrome ": 117.08157361621396, "Inhibitory drug interaction ": 40.90244930920812, "Insomnia ": 3.201936467142211, "Intervertebral disc disorder ": 25.18928080442944, "Jaundice ": 2.113807371817753, "Kaposi's sarcoma ": 36.84762850203537, "Lactic acidosis ": 2.584505602748674, "Lipodystrophy acquired ": 16.553652358115084, "Liver function test abnormal ": 2.8860344175572226, "Liver function test increased ": 3.2125968792793502, "Lymphoma ": 10.450593910608385, "Major depression ": 16.01999119556906, "Mental disorder ": 5.391991499208519, "Mycoplasma infection ": 155.73506054310172, "Nephropathy ": 3.4347291586537425, "Nervous system disorder ": 4.602720773527096, "Nervousness ": 2.4960177052602344, "Neurotoxicity ": 23.15917344924086, "Nightmare ": 5.080839812983594, "Osteopenia ": 3.734166142319564, "Pancreatitis ": 2.5533012752926343, "Pathogen resistance ": 11.68661893294461, "Pneumocystis jirovecii pneumonia ": 7.291528400449626, "Progressive multifocal leukoencephalopathy ": 20.686411956313982, "Proteinuria ": 2.5393731250062097, "Psychotic disorder ": 2.9926273487737465, "Renal failure ": 2.317494151286797, "Renal impairment ": 3.805343784163744, "Sleep disorder ": 3.6675845786876895, "Suicidal ideation ": 6.1280402287620594, "Suicide attempt ": 2.0921659789941742, "Transaminases increased ": 3.5362557579820164, "Treatment noncompliance ": 6.366920213471998, "Tuberculosis ": 12.91509444304382, "Upper-airway cough syndrome ": 29.04998167215432, "Urethral discharge ": 1037.6759625949808, "Urethritis ": 120.02154130022788, "Viral load increased ": 42.6312920656961, "Viral mutation identified ": 23.3951337681442, "Virologic failure ": 13.700562716154405, "Weight increased ": 2.5727958342652557}
+{"Bone pain": 27.846789229238368, "Drug ineffective": 7.129510721873197, "Erythema": 6.323156581725332}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1077.json

@@ -1 +1 @@
-{"Bronchospasm ": 71.21449624211903, "Chest discomfort ": 8.083505292931292, "Condition aggravated ": 2.514484175069501, "Cough ": 12.825390400611669, "Cystic fibrosis ": 706.7825124193597, "Death ": 2.662542502907519, "Drug intolerance ": 7.478322078284209, "Dyspnoea ": 4.937798022050716, "Forced expiratory volume decreased ": 189.36367883747508, "Haemoptysis ": 72.22021283293803, "Infection ": 4.371839808250974, "Lower respiratory tract infection ": 10.94610738108935, "Oxygen saturation decreased ": 12.154623634098035, "Pneumonia ": 3.457184468562118, "Pulmonary function test decreased ": 166.51235418965229, "Wheezing ": 9.034577800287948}
+{"Product use in unapproved indication": 20.188251769515823}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1078.json

@@ -1 +1 @@
-{"Acute kidney injury ": 13.0797155076361, "Blindness ": 3.5442191013587165, "Blood alkaline phosphatase increased ": 2.270878993529436, "Blood creatinine increased ": 6.760496047570615, "Blood pressure decreased ": 2.054228825580104, "Blood urea increased ": 11.694635508630489, "Bronchospasm ": 9.03659129074215, "Clostridium difficile colitis ": 7.330993510280246, "Colitis ": 6.109173088166035, "Condition aggravated ": 2.067618466170088, "Conjunctivitis ": 4.69846648538013, "Corneal opacity ": 50.27483862616008, "Creatinine renal clearance decreased ": 25.58619062807742, "Cystic fibrosis ": 77.28903628029178, "Deafness ": 7.869634104270363, "Deafness neurosensory ": 46.524488193918536, "Drug clearance decreased ": 142.21029874448897, "Drug hypersensitivity ": 4.071393377598039, "Drug ineffective ": 2.3000945416119776, "Drug level increased ": 19.419871543939724, "Drug resistance ": 9.636538525884005, "Eosinophil count abnormal ": 74.65641238920456, "Eosinophilia ": 4.763391445780803, "Eye pain ": 3.4165936959212977, "Eye swelling ": 3.379485528471644, "Eyelid oedema ": 5.160497237279721, "Graft versus host disease ": 10.042811175242203, "Haemoptysis ": 2.673796057072801, "Hypoacusis ": 5.694307325151266, "Hypopyon ": 63.85817046197631, "Hypotension ": 2.726795557140399, "Incorrect route of product administration ": 3.3041985821778623, "Infection ": 2.1847065729397137, "Keratitis ": 51.800995212431694, "Lactic acidosis ": 2.488585383059465, "Leukocytosis ": 5.886981850906022, "Lung disorder ": 2.7022443059056065, "Multiple organ dysfunction syndrome ": 3.664853757759001, "Nephrolithiasis ": 2.809823942435975, "Nephropathy toxic ": 15.63470794955351, "Ocular hyperaemia ": 6.195404658368457, "Ototoxicity ": 174.24190923011594, "Pathogen resistance ": 45.98290959042277, "Pneumonia pseudomonal ": 53.40531967015604, "Productive cough ": 2.4334306499190306, "Pseudomembranous colitis ": 46.61018151627578, "Pseudomonas infection ": 51.875778004570485, "Pulmonary hypertension ": 4.374604381434981, "Renal impairment ": 4.570455530843854, "Renal tubular necrosis ": 76.80143955603143, "Respiratory disorder ": 5.513658245695871, "Respiratory rate decreased ": 25.097384826881523, "Sepsis ": 2.9687810000304475, "Septic shock ": 6.001593484832365, "Staphylococcal infection ": 6.208773911674653, "Therapy non-responder ": 3.680560491155068, "Tinnitus ": 3.927624229707052, "Toxic anterior segment syndrome ": 55.38051686224862, "Toxic epidermal necrolysis ": 8.230342361227871, "Ulcerative keratitis ": 48.27170811765266, "Visual acuity reduced ": 5.19426476495989, "White blood cell count increased ": 4.034530455565668}
+{}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1079.json

@@ -1 +1 @@
-{"Alanine aminotransferase increased ": 2.014991254861531, "Anaphylactic reaction ": 3.16100888584066, "Arthritis ": 4.689665923864119, "C-reactive protein increased ": 2.4315030799917805, "COVID-19 pneumonia ": 7.916775757877641, "Cellulitis ": 7.70476162899105, "Cytokine release syndrome ": 4.824919427073132, "Diverticular perforation ": 57.97647247760111, "Diverticulitis ": 11.816352630252007, "Empyema ": 55.94500559302732, "Haemophagocytic lymphohistiocytosis ": 25.374087184507168, "Hepatic cytolysis ": 2.26173701865858, "Hepatitis ": 6.490518867366277, "Hypercholesterolaemia ": 6.712580878038252, "Hypofibrinogenaemia ": 615.2547251291676, "Hypoxia ": 2.793792458103257, "Infusion related reaction ": 2.5674632269032647, "Intentional product use issue ": 19.627492512694943, "Intestinal perforation ": 23.396485670310167, "Large intestine perforation ": 34.54522123446803, "Leukopenia ": 4.049179285731845, "Neutropenia ": 5.591501546356307, "Neutrophil count decreased ": 2.147475921532841, "No adverse event ": 5.220093348720895, "Off label use ": 7.578902244685533, "Organising pneumonia ": 15.887612891414657, "Pancreatitis acute ": 2.2222536563324087, "Pneumonia ": 2.1753509830563424, "Product use in unapproved indication ": 2.3826606891031403, "Respiratory failure ": 2.242092979196247, "Sepsis ": 4.299022856788757, "Septic shock ": 5.781739902488358, "Staphylococcal infection ": 3.912014760890768, "Therapy non-responder ": 2.250168461349831, "Transaminases increased ": 4.720484109798611, "Urinary tract infection ": 2.03676560152188, "Vasculitis ": 5.825689795595157}
+{"Asthma": 32.77069085038518}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1080.json

@@ -1 +1 @@
-{"Blood creatinine increased ": 6.501998249629692, "Eczema ": 15.21187802587053, "Erythema ": 3.337175232553817, "Swelling ": 4.8010335575525485}
+{"Acute lymphocytic leukaemia": 15.812596111587196, "Acute myeloid leukaemia": 5.498676222119293, "Acute myocardial infarction": 2.51947590093894, "Atelectasis": 5.550066240676565, "Bone disorder": 4.40870021513675, "Bone lesion": 21.1461499036955, "Bradycardia": 4.764114806166199, "Cardiac failure": 2.8863827873838788, "Constipation": 4.409454140698935, "Cutaneous vasculitis": 5.137814944953071, "Cytopenia": 3.35882551348306, "Death": 3.432036286069746, "Deep vein thrombosis": 12.461071063351248, "Disease progression": 5.423874211474828, "Disorientation": 2.00625300028967, "Drug intolerance": 2.168788886952251, "Drug reaction with eosinophilia and systemic symptoms": 5.232076000148883, "Dysaesthesia": 4.974378184157472, "Embolism": 9.526398187641204, "Febrile neutropenia": 3.443644831636957, "Infection": 2.6350909874578123, "Myelodysplastic syndrome": 6.728775349883188, "Neuropathy peripheral": 36.88426625742378, "Neurotoxicity": 4.854351083876428, "Neutropenia": 2.935639048713188, "Oedema": 2.486531273173087, "Oedema peripheral": 3.145100618655224, "Orthostatic hypotension": 3.313278862760212, "Osteonecrosis of jaw": 12.31537943769507, "Pancytopenia": 4.191613805125339, "Paraesthesia": 2.486029349456597, "Peripheral motor neuropathy": 68.0896975870547, "Peripheral sensory neuropathy": 86.03693107542922, "Plasma cell myeloma": 49.61178118538482, "Plasma cell myeloma recurrent": 46.55714078620445, "Plasmacytoma": 74.41602336223518, "Pneumonia": 2.0727183197664885, "Pneumonitis": 2.956133445462064, "Polyneuropathy": 23.35385164384917, "Pulmonary embolism": 8.641650065482954, "Pulmonary hypertension": 2.786863653378804, "Rash maculo-papular": 3.2109750819015503, "Renal impairment": 2.2589405225942327, "Sepsis": 4.265431141318596, "Septic shock": 2.9667337358143904, "Sinus bradycardia": 4.420869636439437, "Therapy non-responder": 9.95303065310162, "Toxic skin eruption": 3.851538552788668, "Transient ischaemic attack": 2.8797802067650737, "Tumour lysis syndrome": 8.188848339258541, "Type 2 lepra reaction": 200.82207246801983, "Varicella zoster virus infection": 25.852618001457504, "Venous thrombosis limb": 11.007824549815108}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1081.json

@@ -1 +1 @@
-{"Condition aggravated ": 3.109116022126352, "Cytomegalovirus infection reactivation ": 67.43635724112387, "Deep vein thrombosis ": 5.057627676767332, "Herpes zoster ": 3.9688817048490073, "Joint swelling ": 4.312288669455672, "Off label use ": 2.287158716890312, "Pulmonary embolism ": 5.458139007201937, "Rheumatoid arthritis ": 4.11645173799976, "Treatment failure ": 11.94247258971962}
+{"Acute lymphocytic leukaemia": 200.72756871358172, "Decreased appetite": 4.9754642239342735, "Febrile neutropenia": 17.563989664438253, "Leukopenia": 10.74683880596742, "Mucosal inflammation": 27.58822158590593, "Myelosuppression": 6.927597858062939, "Stomatitis": 13.94546001504778, "Vomiting": 2.3064690029664376}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1082.json

@@ -1 +1 @@
-{"Cough ": 8.733597327554772}
+{}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1083.json

@@ -1 +1 @@
-{"Blood pressure decreased ": 12.857949718216082, "Cardiac failure ": 10.880075358295745, "Drug ineffective ": 2.0522441958704065, "Drug interaction ": 6.088677632461509, "Hypernatraemia ": 175.80328272586783, "Product use in unapproved indication ": 6.1772332372219525, "Renal impairment ": 8.282371217185235, "Sepsis ": 10.057500191384774}
+{"Acute graft versus host disease": 40.98962384468704, "Acute graft versus host disease in intestine": 162.54282149464166, "Acute graft versus host disease in skin": 191.7586418440809, "Acute promyelocytic leukaemia": 80.76217224837043, "Acute respiratory distress syndrome": 17.10351741163306, "Adenovirus infection": 53.87190121599772, "Anaemia": 4.726986018840199, "Aplastic anaemia": 16.247896771933043, "Chronic graft versus host disease": 39.84050064061359, "Chronic graft versus host disease in skin": 192.51735717586604, "Cystitis haemorrhagic": 41.35647694111013, "Cytomegalovirus infection reactivation": 80.80282490665593, "Deafness": 18.3052108148416, "Febrile neutropenia": 20.523005794198767, "Focal nodular hyperplasia": 679.6024211412794, "Graft versus host disease in gastrointestinal tract": 177.81909816834084, "Graft versus host disease in skin": 66.86096760754364, "Haematotoxicity": 34.0783825233434, "Hepatotoxicity": 15.106087171396371, "Leukopenia": 2.961004387297439, "Medulloblastoma recurrent": 2815.918222338205, "Mucosal inflammation": 62.6153191884963, "Multiple organ dysfunction syndrome": 4.057598456527057, "Myelodysplastic syndrome": 13.236047168380043, "Myelosuppression": 4.700370594290437, "Nervous system disorder": 14.202169728341207, "Neurotoxicity": 10.093362038127054, "Neutropenia": 14.358787677272758, "Off label use": 3.175916712856761, "Osteosarcoma": 502.9693174763792, "Pancytopenia": 2.3438655669244155, "Platelet count decreased": 2.7444765210459163, "Pneumonia cytomegaloviral": 65.051301155106, "Product use in unapproved indication": 5.141070670342077, "Pulmonary arterial hypertension": 17.042966491558634, "Respiratory distress": 3.198589154126713, "Second primary malignancy": 28.662096829500527, "Sepsis": 5.875374627324435, "Short stature": 605.5471836042957, "Stomatitis": 5.199218308356958, "Thrombocytopenia": 13.791380866636636, "Thrombotic microangiopathy": 28.27481572516789, "Venoocclusive liver disease": 49.76301641465533, "Visual impairment": 6.677342690487749}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1084.json

@@ -1 +1 @@
-{"Anaemia ": 6.872565164657599, "Anaplastic lymphoma kinase gene mutation ": 1333.8882349122905, "Blood bilirubin increased ": 4.701416267631148, "Bronchospasm ": 42.62914140024444, "Choroidal dystrophy ": 3234.0518187156263, "Cytopenia ": 12.53149195204519, "Disease progression ": 2.751038524122217, "Disease recurrence ": 10.205481727110444, "Eyelid oedema ": 23.55041516799586, "Eyelid ptosis ": 32.60504106935826, "Febrile neutropenia ": 80.62188377634364, "Haematotoxicity ": 14.682500968407506, "Haematuria ": 2.766400653094257, "Haemoglobin decreased ": 2.9813532911053526, "Interstitial lung disease ": 2.446565015257592, "Leukopenia ": 6.149278453926653, "Lymphocyte count decreased ": 8.37237025275072, "Madarosis ": 111.006133198286, "Malignant neoplasm progression ": 6.125014988030871, "Mucosal inflammation ": 10.095124714877947, "Myelosuppression ": 11.273516311575714, "Neoplasm progression ": 4.272878503168244, "Neuroblastoma ": 528.8684434796431, "Neutropenia ": 17.172452753577932, "Neutrophil count decreased ": 8.934665079638322, "Off label use ": 2.005127058496978, "Pancytopenia ": 14.640763910154396, "Platelet count decreased ": 6.026869172562522, "Product use in unapproved indication ": 6.3898192679136105, "Product use issue ": 4.312006486974255, "Red blood cell count decreased ": 8.22848145155893, "Respiratory failure ": 2.036785588062464, "Retinal vascular occlusion ": 66.39421643281551, "Retinoblastoma ": 3095.191333454762, "Small cell lung cancer ": 69.52729451348233, "Stomatitis ": 2.4378322198150792, "Thrombocytopenia ": 9.149455992278794, "Treatment failure ": 6.504851253767202, "Upper respiratory tract infection ": 5.248301833835703, "Vascular occlusion ": 44.88639736293338, "Vitreous haemorrhage ": 50.29457033338881, "White blood cell count decreased ": 8.70243420292299}
+{"Abortion spontaneous": 227.04082780582536, "Maternal exposure during pregnancy": 96.34696146561234}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1085.json

@@ -1 +1 @@
-{"Acute kidney injury ": 2.905409084821205, "Acute respiratory failure ": 3.3555354295531385, "Anaemia ": 2.98562578075412, "Angioedema ": 2.593441455580831, "Aphthous ulcer ": 9.09863849925276, "Ascites ": 3.935584745180045, "Blood alkaline phosphatase increased ": 3.923368540893705, "Blood creatinine increased ": 7.317667885973548, "Blood lactate dehydrogenase increased ": 2.6574965554513503, "Blood triglycerides increased ": 13.50879310967688, "Blood urea increased ": 4.145565248902495, "C-reactive protein increased ": 2.218480462493136, "Cerebral haemorrhage ": 2.760483759069148, "Death ": 4.208830709779996, "Dehydration ": 2.0036839773924124, "Diabetes mellitus ": 3.2700989986205378, "Disease progression ": 32.27406788403763, "Extravasation ": 12.820160625412464, "Febrile neutropenia ": 2.395941843603665, "Flushing ": 5.590008523980762, "General physical health deterioration ": 3.765928004252657, "Haemoptysis ": 2.4054583742737488, "Hypercalcaemia ": 3.94342967994974, "Hyperglycaemia ": 3.779807369931933, "Hyperkalaemia ": 2.122195026933143, "Hyperlipidaemia ": 4.02508443267051, "Hypersensitivity ": 2.250187994703694, "Hypertriglyceridaemia ": 11.689391749696656, "Infusion related reaction ": 4.113035691601546, "Interstitial lung disease ": 25.40951788744201, "Intestinal perforation ": 9.980368857218483, "Lung disorder ": 2.6034988999078728, "Lung infiltration ": 20.929469791936743, "Mantle cell lymphoma ": 140.79980342004131, "Metastatic renal cell carcinoma ": 46.4807089170371, "Microcytic anaemia ": 34.65440871462857, "Mucosal inflammation ": 8.135266549182274, "Nail disorder ": 17.982508451786252, "Neoplasm malignant ": 4.114377887002928, "Neoplasm progression ": 14.6171425037178, "Oedema peripheral ": 2.14909283068786, "Oral pain ": 3.0025155885227512, "Oxygen saturation decreased ": 2.470699428981729, "Pancytopenia ": 2.0059226652056497, "Pericardial effusion ": 3.248567297118669, "Peritonitis ": 5.153673278473041, "Platelet count decreased ": 4.159827025248079, "Pleural effusion ": 9.44131382555991, "Pneumocystis jirovecii pneumonia ": 23.487759819321926, "Pneumonia ": 2.5242735933770377, "Pneumonitis ": 17.297661059169375, "Product use in unapproved indication ": 2.5525002225622377, "Pulmonary fibrosis ": 3.1487357653292696, "Pulmonary oedema ": 2.302689229827512, "Renal cancer ": 11.200809613314249, "Renal cancer metastatic ": 55.3993001874512, "Renal cell carcinoma ": 84.2343429833472, "Renal failure ": 3.3586739360783544, "Stomatitis ": 6.7169809363216375, "Thrombocytopenia ": 3.050698946714851}
+{"Acute coronary syndrome": 4.833472647267703, "Acute kidney injury": 2.468818293486269, "Acute myocardial infarction": 8.448810431637515, "Amaurosis": 39.52333191306073, "Angina unstable": 5.615154263583051, "Asphyxia": 37.63570374965063, "Atrioventricular block": 5.77635850162484, "Atrioventricular block complete": 6.731418726769471, "Blood loss anaemia": 50.74725054408197, "Bronchial haemorrhage": 95.99923570525895, "Cardiogenic shock": 3.040671287583894, "Cerebral haemorrhage": 7.171756197195853, "Chest discomfort": 9.460068622083837, "Chronic gastritis": 48.18818488575063, "Conjunctival haemorrhage": 10.210196166291176, "Coronary artery occlusion": 6.677786758875344, "Coronary artery stenosis": 15.183550255424525, "Diarrhoea haemorrhagic": 10.417887976840806, "Drug interaction": 4.957388398314164, "Duodenal ulcer": 15.889728071557718, "Duodenal ulcer haemorrhage": 32.86101281959504, "Dyspnoea": 4.729528355974472, "Dyspnoea at rest": 16.622340433961543, "Ecchymosis": 19.24954589386545, "Electrocardiogram ST segment elevation": 6.6434971709886135, "Epistaxis": 6.616247987252902, "Eye haemorrhage": 2.471622456330378, "Faeces discoloured": 16.77884091353526, "Gastric haemorrhage": 9.73669946209261, "Gastric mucosal lesion": 67.19114694267986, "Gastric ulcer": 7.536851715733031, "Gastric ulcer haemorrhage": 20.12180399203093, "Gastritis erosive": 18.44878041359304, "Gastrointestinal haemorrhage": 26.04518349788933, "Gingival bleeding": 14.890783877736542, "Gout": 5.717688853474336, "Haematemesis": 32.75609737472881, "Haematochezia": 17.488758055730678, "Haematoma": 3.075330957252272, "Haematuria": 9.169292620862317, "Haemoglobin decreased": 6.542218569003436, "Haemoptysis": 11.78474493545197, "Haemorrhage": 3.423993774908652, "Haemorrhage intracranial": 12.488215838481278, "Haemorrhage subcutaneous": 28.148778203318603, "Haemorrhage urinary tract": 13.819169447400435, "Haemorrhoidal haemorrhage": 10.6583566207891, "Haemothorax": 11.45930800695112, "Incorrect dose administered": 2.1559789812340373, "Iron deficiency anaemia": 4.468393646110373, "Labelled drug-drug interaction issue": 220.60996919041324, "Labelled drug-drug interaction medication error": 199.4374895009144, "Lower gastrointestinal haemorrhage": 62.99539964068568, "Melaena": 59.43068126127158, "Myopathy": 4.604628449945429, "Occult blood positive": 35.740598372901744, "Pericardial haemorrhage": 16.068820801386895, "Platelet aggregation inhibition": 471.91629779597486, "Post procedural haemorrhage": 5.864217060738054, "Product administration error": 3.396168971554871, "Product prescribing issue": 28.85639652403592, "Pulmonary alveolar haemorrhage": 14.28467889812784, "Pulmonary haemorrhage": 14.73140373657302, "Purpura": 2.5606403193661684, "Rectal haemorrhage": 4.633215208097326, "Respiratory rate increased": 6.941773923038289, "Respiratory tract haemorrhage": 38.35344174403821, "Rhabdomyolysis": 12.100416845817044, "Shock haemorrhagic": 8.554998460301464, "Sinus arrest": 44.90060240060416, "Subarachnoid haemorrhage": 11.808347174243016, "Subdural haematoma": 4.562433482018913, "Tachypnoea": 8.386228561773121, "Thrombotic thrombocytopenic purpura": 6.361380751466973, "Treatment noncompliance": 2.6151451612268586, "Upper gastrointestinal haemorrhage": 123.49584936936108, "Vascular stent thrombosis": 30.77366095198895, "Ventricular asystole": 129.26035004649873}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1086.json

@@ -1 +1 @@
-{"Asphyxia ": 3.1347416653246403, "Blindness ": 5.665544494556956, "Blood glucose abnormal ": 31.597072799389988, "Blood glucose decreased ": 27.680425353446108, "Blood glucose fluctuation ": 36.943233230655885, "Blood glucose increased ": 31.48533019181776, "Caesarean section ": 6.202470264167431, "Cardiac disorder ": 2.6994414625406207, "Cataract ": 7.476190820516678, "Cerebrovascular accident ": 2.801682993135879, "Dementia ": 6.092282818276282, "Device defective ": 35.492507007626386, "Device delivery system issue ": 18.7685460851876, "Device issue ": 29.77402528459545, "Device leakage ": 6.918160748120319, "Device occlusion ": 10.82765539844747, "Device operational issue ": 243.5743004184508, "Diabetes mellitus inadequate control ": 73.25068238530734, "Diabetic ketoacidosis ": 3.78987716326205, "Diabetic metabolic decompensation ": 43.04469094927012, "Disability ": 14.68356855096157, "Drug dose omission by device ": 11.456468695840517, "Drug ineffective ": 2.663614879177066, "Expired product administered ": 3.7689565369952063, "Extra dose administered ": 8.135734389530755, "Eye disorder ": 2.5231741222247206, "Eye haemorrhage ": 3.167798709297984, "Feeling abnormal ": 2.199732907308825, "Glaucoma ": 3.3578785022059754, "Glycosylated haemoglobin abnormal ": 26.25361228980562, "Glycosylated haemoglobin increased ": 29.2511753821142, "Hospitalisation ": 3.132614835169901, "Hyperglycaemia ": 25.28186019143705, "Hypoacusis ": 3.283023781992304, "Hypoglycaemia ": 16.312080791874546, "Hypoglycaemic coma ": 2.698932040269262, "Hypoglycaemic unconsciousness ": 4.741306184073823, "Inappropriate schedule of product administration ": 7.017598988595349, "Incorrect dose administered ": 5.018029843012827, "Incorrect dose administered by device ": 28.157920482205046, "Injection site bruising ": 9.702491641405846, "Injection site haemorrhage ": 6.315330031783683, "Injection site mass ": 4.058109619468821, "Intentional dose omission ": 8.955473371269257, "Intentional product misuse ": 3.832139251058136, "Intentional product use issue ": 4.008458175524142, "Ketoacidosis ": 3.240557177342316, "Loss of consciousness ": 2.022951403150728, "Multiple use of single-use product ": 36.7594532910498, "Needle issue ": 6.434243098805027, "Neoplasm malignant ": 2.424678179938528, "Nervousness ": 3.000444619679882, "Product dispensing error ": 2.7433617618824675, "Product dose omission in error ": 6.405887570616123, "Product dose omission issue ": 4.9971316912930535, "Product prescribing issue ": 4.653400593218763, "Product quality issue ": 10.657454019343618, "Product storage error ": 52.87165737838029, "Product use issue ": 3.8809653362097616, "Renal disorder ": 3.1431770715059093, "Stress ": 2.5029855386445985, "Surgery ": 3.3646165505663075, "Therapeutic response decreased ": 4.557087721233061, "Thirst ": 2.8953953280919102, "Unevaluable event ": 6.197248355539708, "Visual impairment ": 5.016017648068181, "Weight increased ": 2.615702395813786, "Wrong technique in device usage process ": 23.08276218074281}
+{"Acinetobacter infection": 277.80555008510726, "Acute respiratory distress syndrome": 22.522066524966064, "Bacteraemia": 36.34375560645968, "Blood bilirubin increased": 5.615273390056331, "Coagulopathy": 13.326420063187022, "Condition aggravated": 4.289461761704901, "Drug ineffective": 6.462126082232314, "Drug resistance": 27.68949377920479, "Electrocardiogram QT prolonged": 4.693007721334333, "Hepatic function abnormal": 6.801182166166319, "Klebsiella infection": 172.88050144707557, "Liver function test abnormal": 10.755994371264103, "Liver injury": 10.415109052940736, "Mental status changes": 13.007818977370368, "Off label use": 3.97389821027949, "Pancreatitis acute": 7.436616929245351, "Pathogen resistance": 136.24746640883976, "Platelet count decreased": 3.346382860616958, "Product use issue": 3.2657434304826096, "Pseudomembranous colitis": 41.874952011277145, "Sepsis": 4.944732210962315, "Septic shock": 8.127386617119294, "Thrombocytopenia": 2.779566695119553, "Tinnitus": 3.800741086353969}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1087.json

@@ -1 +1 @@
-{"Accident ": 4.687288606191155, "Anal incontinence ": 2.86666338473011, "Angle closure glaucoma ": 5.705853653412107, "Anticholinergic syndrome ": 14.658867231176783, "Aphonia ": 2.386394544325944, "Back disorder ": 4.491182956468194, "Benign prostatic hyperplasia ": 24.31190126888239, "Bladder dilatation ": 41.391904487724005, "Bladder disorder ": 25.227542981438216, "Bladder obstruction ": 96.28437012166049, "Bladder pain ": 39.66649432765731, "Bladder spasm ": 46.27468605207611, "Blindness ": 2.255868560268788, "Blood urine present ": 6.4138136772640895, "Body height decreased ": 17.66579520163965, "Cataract ": 2.5011124588853395, "Cerebral disorder ": 3.632783778645541, "Cerebrovascular accident ": 2.4617214737178603, "Cognitive disorder ": 3.928432262636733, "Confusional state ": 2.160341801823328, "Constipation ": 6.035025213305628, "Cystitis ": 11.190037512622222, "Dementia ": 18.64045421702887, "Dementia Alzheimer's type ": 6.946127994218147, "Drug ineffective ": 2.0789506359057905, "Dry eye ": 10.75103012716396, "Dry mouth ": 21.3394156589005, "Dry throat ": 19.85959229979885, "Dysgraphia ": 6.4057347398106215, "Dysphagia ": 2.696459266231248, "Dysphonia ": 2.247012548641629, "Dysstasia ": 2.283923815862176, "Dysuria ": 27.516202212383007, "Eructation ": 3.4894684076972378, "Expired product administered ": 3.0213527704479746, "Extra dose administered ": 2.127016158423624, "Eye disorder ": 3.862410515655502, "Faecaloma ": 6.322670950683489, "Fall ": 2.7652926131467943, "Feeling abnormal ": 2.07285555392757, "Fluid retention ": 2.902403617672097, "Gait disturbance ": 2.5453545002188736, "Gingival pain ": 3.49278620452905, "Glaucoma ": 7.079840221839622, "Head injury ": 2.3192771840047235, "Hydronephrosis ": 6.592974148708766, "Hypertonic bladder ": 20.09643440232842, "Hypoacusis ": 4.832171904964978, "Hypotonic urinary bladder ": 167.9625798856184, "Ileus ": 3.5806682207386484, "Illness ": 2.291088240965124, "Implant site erosion ": 169.6004886034721, "Implant site infection ": 59.44726748539614, "Inappropriate antidiuretic hormone secretion ": 2.4605908820595768, "Incontinence ": 6.274686445724933, "Intentional product misuse ": 2.1827080823906493, "Intestinal obstruction ": 2.8572165296643317, "Intraocular pressure increased ": 4.718217787779083, "Joint injury ": 2.7403460407402047, "Kidney infection ": 3.9097138864339738, "Lip dry ": 7.053491848512653, "Lip swelling ": 2.36492739717607, "Memory impairment ": 3.3007688490311677, "Mental impairment ": 3.975150120917871, "Micturition disorder ": 16.291095437403083, "Micturition urgency ": 23.460789938807768, "Middle insomnia ": 5.353819996751486, "Mouth swelling ": 3.290525796172336, "Multiple sclerosis ": 6.419184797446486, "Muscle tightness ": 4.817108927544359, "Musculoskeletal disorder ": 8.347428426560988, "Nasal dryness ": 8.477493313926937, "Neoplasm malignant ": 2.416904902567219, "Nocturia ": 18.684595985090297, "Overweight ": 6.977681065854134, "Parkinson's disease ": 11.154932242831832, "Pelvic pain ": 4.3015003600387685, "Performance status decreased ": 6.270564642182218, "Pharyngeal swelling ": 2.2650142803064, "Pollakiuria ": 11.34076737873998, "Post micturition dribble ": 133.10271977977422, "Product dispensing error ": 5.17099796717938, "Product prescribing error ": 6.357167940172565, "Prostatic disorder ": 9.568910677146164, "Prostatomegaly ": 10.84742633209079, "Pyelonephritis ": 2.459373624519442, "Residual urine volume increased ": 467.9031164856961, "Road traffic accident ": 2.2744803416205794, "Sinus disorder ": 2.8776509727295245, "Speech disorder ": 2.191302984058232, "Spinal disorder ": 6.368500708687698, "Subileus ": 13.920481368522324, "Swollen tongue ": 2.633845946699353, "Therapeutic product effect incomplete ": 5.724249445277831, "Therapeutic response decreased ": 4.108954361501141, "Thirst ": 8.227023601584046, "Unevaluable event ": 2.53481196005712, "Urge incontinence ": 35.666869643098714, "Urinary hesitation ": 29.163745407333025, "Urinary incontinence ": 12.796172326019976, "Urinary retention ": 300.15280838641866, "Urinary tract disorder ": 13.922313747760397, "Urinary tract infection ": 5.819138300245455, "Urinary tract obstruction ": 24.78550128291997, "Urine abnormality ": 7.234271439301564, "Urine flow decreased ": 61.63556198322418, "Urine output decreased ": 2.961186779368628, "Vision blurred ": 4.571683440713003, "Weight bearing difficulty ": 8.776479087454058, "Weight fluctuation ": 7.170977782469854, "Wound dehiscence ": 28.50521307785547, "Wound drainage ": 169.6004886034721, "Wrist fracture ": 2.138625514083853, "Wrong technique in product usage process ": 2.1179398221122367}
+{"Arrhythmia": 7.027505058064821, "Atrial fibrillation": 24.6926801367687, "Drug interaction": 5.800276807716031, "Electrocardiogram QT prolonged": 10.489360458467567, "Heart rate decreased": 14.197114362627648, "Heart rate increased": 6.239990256040112, "Visual impairment": 3.519889071561064}