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{"acne": 3.24, "acute kidney injury": 2.39, "blood creatine phosphokinase increased": 3.62, "blood creatinine increased": 2.04, "cholestasis": 3.98, "colitis": 6.73, "constipation": 2.23, "death": 10.27, "decreased appetite": 2.22, "dehydration": 3.81, "dermatitis acneiform": 29.13, "detachment of retinal pigment epithelium": 28.85, "dry skin": 2.33, "ejection fraction decreased": 3.27, "electrocardiogram qt prolonged": 3.85, "enterocolitis": 7.79, "eye disorder": 4.58, "feeding disorder": 2.83, "haematochezia": 2.07, "hepatic cytolysis": 5.83, "hepatic function abnormal": 2.56, "hepatitis": 2.0, "hepatotoxicity": 2.0, "hypoacusis": 3.34, "ileus": 5.65, "illness": 2.56, "immune-mediated enterocolitis": 6.13, "intestinal obstruction": 6.3, "large intestinal ulcer": 42.03, "liver disorder": 4.23, "macular oedema": 6.73, "melaena": 2.08, "melanocytic naevus": 28.96, "neoplasm progression": 33.6, "off label use": 8.75, "pancreatitis acute": 2.09, "product dose omission issue": 2.41, "product physical issue": 6.14, "product prescribing error": 5.9, "product use complaint": 13.68, "product use in unapproved indication": 22.79, "product use issue": 2.46, "rectal haemorrhage": 2.64, "renal disorder": 2.58, "renal impairment": 3.0, "retinal detachment": 18.53, "retinal oedema": 23.63, "rhabdomyolysis": 3.07, "second primary malignancy": 25.93, "serous retinal detachment": 658.71, "serous retinopathy": 806.52, "underdose": 6.7, "uveitis": 16.12, "vision blurred": 2.97, "visual impairment": 2.7}