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{"acute hepatic failure": 4.9, "adenocarcinoma of colon": 34.47, "adverse drug reaction": 2.18, "alanine aminotransferase increased": 6.12, "altered state of consciousness": 2.19, "ammonia increased": 12.69, "aphonia": 2.19, "ascites": 8.35, "aspartate aminotransferase increased": 8.5, "asthenia": 2.08, "bilirubin conjugated increased": 7.43, "blister": 6.76, "blood albumin decreased": 3.46, "blood alkaline phosphatase increased": 2.92, "blood bilirubin increased": 20.93, "blood lactate dehydrogenase increased": 2.75, "blood pressure increased": 2.7, "blood thyroid stimulating hormone increased": 5.49, "c-reactive protein increased": 3.65, "cancer pain": 9.52, "carbohydrate antigen 19-9 increased": 33.84, "carcinoembryonic antigen increased": 71.65, "cholangitis": 5.88, "cholecystitis": 3.2, "chromaturia": 3.76, "colon cancer": 74.29, "colon cancer metastatic": 87.06, "colon cancer recurrent": 123.84, "colorectal cancer": 487.08, "colorectal cancer metastatic": 433.83, "death": 2.37, "decreased appetite": 3.57, "dermatitis bullous": 3.21, "dermatitis exfoliative generalised": 5.18, "diarrhoea": 2.24, "disease progression": 2.04, "disseminated intravascular coagulation": 10.38, "drug eruption": 12.35, "drug-induced liver injury": 7.7, "dry skin": 2.14, "dysphonia": 16.49, "eating disorder": 2.58, "encephalopathy": 2.74, "erythema multiforme": 19.84, "faeces discoloured": 2.04, "gastrointestinal perforation": 26.34, "gastrointestinal stromal tumour": 31.7, "general physical health deterioration": 3.1, "gingival bleeding": 2.05, "hepatic cancer": 3.51, "hepatic encephalopathy": 18.54, "hepatic enzyme increased": 2.05, "hepatic failure": 10.46, "hepatic function abnormal": 16.11, "hepatitis fulminant": 12.31, "hepatocellular carcinoma": 19.84, "hepatotoxicity": 5.66, "hydronephrosis": 3.96, "hyperammonaemia": 9.82, "hyperbilirubinaemia": 11.1, "hyperkeratosis": 21.54, "hypertension": 4.99, "hyperthermia": 2.29, "hypertransaminasaemia": 2.63, "hypoalbuminaemia": 5.68, "hypocalcaemia": 3.52, "hypophagia": 2.91, "hypophosphataemia": 6.02, "hypothyroidism": 4.98, "ileus": 5.75, "intestinal obstruction": 3.76, "intestinal perforation": 4.64, "jaundice": 11.5, "liver disorder": 7.72, "liver function test abnormal": 3.23, "liver function test increased": 4.55, "liver injury": 4.65, "melaena": 2.78, "metastases to bone": 4.0, "metastases to central nervous system": 7.48, "metastases to liver": 22.93, "metastases to lung": 36.91, "metastases to lymph nodes": 12.92, "metastases to peritoneum": 21.99, "metastasis": 4.46, "mouth ulceration": 3.35, "mucosal inflammation": 9.99, "nephrotic syndrome": 3.35, "ocular icterus": 9.93, "off label use": 7.35, "oral pain": 3.48, "pain of skin": 8.02, "palmar-plantar erythrodysaesthesia syndrome": 102.96, "performance status decreased": 2.78, "peritonitis": 5.14, "plantar erythema": 46.87, "platelet count decreased": 8.34, "posterior reversible encephalopathy syndrome": 6.71, "proctalgia": 5.94, "product use in unapproved indication": 2.32, "protein urine present": 13.78, "proteinuria": 9.37, "pulmonary mass": 3.05, "rash": 2.02, "rash erythematous": 2.09, "rash maculo-papular": 5.06, "rash papular": 2.66, "rectal adenocarcinoma": 36.59, "rectal cancer": 54.98, "rectal cancer metastatic": 101.27, "rectal haemorrhage": 2.11, "renal impairment": 2.23, "skin disorder": 2.13, "skin exfoliation": 11.56, "skin fissures": 13.85, "skin induration": 12.55, "skin reaction": 2.14, "skin swelling": 6.83, "skin toxicity": 17.6, "skin ulcer": 5.09, "skin warm": 2.07, "stevens-johnson syndrome": 4.75, "stoma site haemorrhage": 45.14, "stomatitis": 7.34, "thrombocytopenia": 2.35, "toxic skin eruption": 4.07, "transaminases increased": 3.97, "tumour haemorrhage": 12.14, "tumour marker increased": 13.62, "weight decreased": 2.3, "yellow skin": 3.62}