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{"acute kidney injury": 2.97, "adrenal insufficiency": 9.18, "alanine aminotransferase increased": 5.42, "aspartate aminotransferase increased": 4.73, "blood bilirubin increased": 2.66, "blood pressure increased": 2.98, "blood thyroid stimulating hormone increased": 13.81, "colitis": 2.57, "decreased appetite": 2.77, "dehydration": 2.24, "diarrhoea": 4.73, "disease progression": 5.65, "drug-induced liver injury": 6.94, "dysphonia": 15.69, "general physical health deterioration": 3.43, "hepatic function abnormal": 6.44, "hepatitis": 18.99, "hepatotoxicity": 13.6, "hyperkalaemia": 4.01, "hypertension": 10.47, "hyperthyroidism": 7.56, "hypertransaminasaemia": 10.46, "hypothyroidism": 29.82, "immune-mediated hepatic disorder": 45.03, "immune-mediated hypothyroidism": 35.31, "immune-mediated myocarditis": 25.21, "liver disorder": 3.2, "liver function test increased": 3.53, "malignant neoplasm progression": 11.27, "metastatic renal cell carcinoma": 19.56, "mucosal inflammation": 9.5, "neoplasm progression": 24.16, "off label use": 2.5, "osteonecrosis of jaw": 10.06, "palmar-plantar erythrodysaesthesia syndrome": 22.89, "pancreatitis acute": 2.66, "pneumonitis": 2.93, "polycythaemia": 50.11, "posterior reversible encephalopathy syndrome": 22.1, "product use in unapproved indication": 3.34, "proteinuria": 10.4, "stomatitis": 5.57, "therapy partial responder": 24.95, "thyroiditis": 14.65, "transaminases increased": 6.63, "tubulointerstitial nephritis": 8.91, "weight decreased": 3.16}