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{"Abdominal abscess": 4.218059667625735, "Acute hepatic failure": 3.914022727578105, "Adenocarcinoma of colon": 37.6148695725063, "Alanine aminotransferase increased": 5.307689503512639, "Alpha 1 foetoprotein increased": 8.002770564380778, "Ammonia increased": 9.495013922609548, "Anal abscess": 4.952402543059005, "Anal fistula": 6.595486222015647, "Aphonia": 2.55817137582958, "Ascites": 7.269938269043571, "Aspartate aminotransferase increased": 6.9644605263144, "Asthenia": 2.464014292878453, "Biliary obstruction": 6.794278220510165, "Bilirubin conjugated increased": 7.916564433898229, "Blister": 4.34699061045532, "Blood albumin decreased": 4.575094701203058, "Blood alkaline phosphatase increased": 2.4160293558668413, "Blood bilirubin increased": 18.143605970705973, "Blood lactate dehydrogenase increased": 2.5588509426621973, "Blood pressure increased": 2.5831125861089967, "Blood thyroid stimulating hormone increased": 5.465871739228595, "C-reactive protein increased": 2.944054792195961, "Cachexia": 3.156855688692747, "Cancer pain": 17.15482893216877, "Carbohydrate antigen 19-9 increased": 39.69305559320301, "Carcinoembryonic antigen increased": 85.28076811996347, "Cardiac dysfunction": 3.819022199562944, "Cell death": 5.177619804681565, "Cholangitis": 7.163498903841889, "Cholecystitis": 3.506593248066369, "Chromaturia": 3.289256791702419, "Colon cancer": 63.01735440490184, "Colon cancer metastatic": 91.76225954538565, "Colon cancer recurrent": 131.97498990633417, "Colorectal cancer": 20.789843672744063, "Colorectal cancer metastatic": 409.7156699371501, "Colorectal cancer recurrent": 325.45601586150894, "Colorectal cancer stage IV": 94.30195652008835, "Coma hepatic": 9.135235659397043, "Death": 2.408789695133592, "Decreased appetite": 3.9401919381728985, "Dermatitis bullous": 2.726403222348529, "Dermatitis exfoliative": 3.8163338805428335, "Dermatitis exfoliative generalised": 3.2921134231959983, "Diarrhoea": 2.4200739580385617, "Disease progression": 2.331310623178662, "Disseminated intravascular coagulation": 8.093017908698611, "Drug eruption": 7.083534351605588, "Drug-induced liver injury": 4.874594401015791, "Dry skin": 2.1585553927001384, "Duodenal perforation": 17.84452260203771, "Dysphonia": 14.28653368540536, "Eastern Cooperative Oncology Group performance status worsened": 9.22460950437574, "Eating disorder": 2.40509063864275, "Erythema multiforme": 13.90676315287218, "Faeces discoloured": 2.045355825407793, "Gastrointestinal perforation": 30.192403927791126, "Gastrointestinal stromal tumour": 29.829892794878464, "General physical health deterioration": 2.7473036898688576, "Gingival bleeding": 2.2531532524976754, "Glossitis": 2.8679538698210845, "Haemorrhage urinary tract": 3.711476793133804, "Hepatic encephalopathy": 16.78642664509995, "Hepatic failure": 8.636632298966086, "Hepatic function abnormal": 10.63835845570408, "Hepatic mass": 5.137931716152903, "Hepatitis fulminant": 7.0359841607686455, "Hepatocellular carcinoma": 17.792609847090493, "Hepatotoxicity": 5.156989869061184, "Hydronephrosis": 4.055185546224528, "Hyperammonaemia": 4.869945673019456, "Hyperbilirubinaemia": 8.973271325476142, "Hyperkeratosis": 21.792225227511054, "Hypertension": 4.748996929669808, "Hyperthermia": 2.5571918749185523, "Hypertransaminasaemia": 2.8283745600621306, "Hypoalbuminaemia": 5.612907304162706, "Hypocalcaemia": 3.3513129373358432, "Hypophagia": 2.9216083736855487, "Hypophosphataemia": 5.704116111091675, "Hypoproteinaemia": 6.983315686377209, "Hypothyroidism": 4.873288170592558, "Ileus": 5.109396343139419, "Intestinal haemorrhage": 5.545258221650082, "Intestinal obstruction": 3.6023502676312416, "Intestinal perforation": 5.331124309140023, "Jaundice": 7.761999048342339, "Jaundice cholestatic": 4.1565007985323765, "Large intestine perforation": 3.2184559359953058, "Liver disorder": 6.031307863881112, "Liver function test abnormal": 2.787069006118719, "Liver function test increased": 4.644175037317708, "Liver injury": 2.698425874431802, "Lower gastrointestinal haemorrhage": 2.869987148046988, "Lymphadenopathy mediastinal": 5.82610558980444, "Mediastinal mass": 24.471039095289207, "Melaena": 2.8155030696838548, "Metastases to abdominal cavity": 24.28542944959026, "Metastases to adrenals": 14.871516198932746, "Metastases to bone": 4.69540707373648, "Metastases to central nervous system": 10.325037494890625, "Metastases to liver": 23.874126517292257, "Metastases to lung": 38.118732324234486, "Metastases to lymph nodes": 14.775683567287034, "Metastases to pelvis": 26.880117247900117, "Metastases to peritoneum": 23.85734842534587, "Metastases to spine": 3.727047530953574, "Metastasis": 5.534298052188569, "Mouth ulceration": 3.5164763401527064, "Mucosal disorder": 3.035452100708784, "Mucosal inflammation": 9.972290900157718, "Nephrotic syndrome": 3.939537064570632, "Ocular icterus": 8.2514143042709, "Off label use": 6.924034587570523, "Oral mucosa erosion": 5.666083055556985, "Oral pain": 2.9663636300145666, "Pain of skin": 10.980126848822444, "Palmar-plantar erythrodysaesthesia syndrome": 108.34766489515604, "Palmoplantar keratoderma": 19.616636582000588, "Paronychia": 2.908198723791648, "Performance status decreased": 3.938495428818477, "Peritonitis": 4.713961807887195, "Physical deconditioning": 2.156306249538904, "Plantar erythema": 51.83478744048034, "Platelet count decreased": 8.013341828541762, "Portal hypertension": 3.245864818011414, "Posterior reversible encephalopathy syndrome": 7.168029557811422, "Pre-existing condition improved": 8.243145150574604, "Proctalgia": 5.255582445562452, "Protein urine present": 13.60207694931976, "Proteinuria": 9.854963822550864, "Pulmonary cavitation": 14.51458307726868, "Pulmonary mass": 2.998664571389495, "Rash maculo-papular": 2.8064116937230037, "Rash papular": 2.3956440412979365, "Rectal adenocarcinoma": 49.00619672516794, "Rectal cancer": 49.09719744174818, "Rectal cancer metastatic": 113.54632127258456, "Retroperitoneal lymphadenopathy": 16.280993968272302, "Secondary hypertension": 25.820594936627167, "Skin disorder": 2.6989420433026377, "Skin erosion": 3.8239177110882583, "Skin exfoliation": 9.657830387498988, "Skin fissures": 14.26684554132523, "Skin induration": 7.926535035729247, "Skin injury": 3.837779109460167, "Skin reaction": 2.5102875397970736, "Skin swelling": 7.935948615628367, "Skin toxicity": 22.68918971133137, "Skin ulcer": 4.842441244134107, "Skin warm": 2.887390944099752, "Skin weeping": 12.210612125245008, "Small intestinal perforation": 13.151896442518924, "Stevens-Johnson syndrome": 2.54660755667294, "Stoma site haemorrhage": 53.40505685373885, "Stomatitis": 6.527626139106558, "Subileus": 5.516226425844927, "Temperature intolerance": 2.4642145382163694, "Terminal state": 3.174351485649747, "Therapeutic product ineffective": 3.411395627791608, "Thrombocytopenia": 2.1173809227600966, "Toxic skin eruption": 2.683455399512715, "Transaminases increased": 3.523020840070469, "Tumour haemorrhage": 16.490273241596334, "Tumour marker increased": 16.638654375736774, "Tumour necrosis": 18.155347248931783, "Tumour pain": 14.553877713781176, "Weight decreased": 2.1320964262044164, "Yellow skin": 3.511508633704869}