updating data

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1.json

@@ -1 +1 @@
-{"Constipation": 17.649962607021507, "Dyspnoea": 3.5490943061549447, "Flatulence": 77.68403086713583, "Oropharyngeal pain": 23.775160354588635, "Stevens-Johnson syndrome": 67.16782399335501, "Toxic epidermal necrolysis": 102.8388320701753}
+{"asthenia": 4.7}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/10.json

@@ -1 +1 @@
-{"Emotional distress": 161.85208465362794, "Hypersensitivity": 70.04082379006084, "Injury": 405.2825412437928}
+{"anaemia": 4.25, "ascites": 8.09, "aspartate aminotransferase increased": 2.13, "breast cancer": 2.63, "breast cancer metastatic": 68.82, "cholangitis": 27.72, "colitis": 4.29, "dehydration": 2.99, "disease progression": 3.72, "drug eruption": 3.53, "drug-induced liver injury": 2.78, "febrile neutropenia": 25.2, "hypophagia": 19.46, "immune-mediated enterocolitis": 24.48, "interstitial lung disease": 17.96, "leukopenia": 2.74, "liver disorder": 3.44, "maligt neoplasm progression": 17.43, "metastases to bone": 42.29, "metastases to central nervous system": 9.59, "metastases to liver": 21.92, "metastases to lung": 17.24, "myelosuppression": 7.63, "neoplasm progression": 6.88, "neuropathy peripheral": 9.41, "neutropenia": 5.14, "neutrophil count decreased": 10.32, "off label use": 2.51, "palmar-plantar erythrodysaesthesia syndrome": 3.24, "peripheral sensory neuropathy": 18.17, "pik3ca-activated mutation": 405.54, "pleural effusion": 3.08, "pneumonia": 2.27, "pneumonitis": 13.26, "sepsis": 2.93, "septic shock": 5.6, "stomatitis": 5.37, "thrombocytopenia": 2.92, "white blood cell count decreased": 4.02}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1001.json

@@ -1 +1 @@
-{"Blood creatinine increased": 10.554728842142492, "Kidney transplant rejection": 453.1409148085539}
+{"blood creatinine increased": 9.54, "cardiac failure": 12.22, "cognitive disorder": 17.57, "constipation": 3.61, "death": 5.45, "disease progression": 5.68, "dizziness": 2.1, "fall": 2.61, "renal impairment": 4.34, "taste disorder": 12.73, "weight increased": 3.88}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1002.json

@@ -1 +1 @@
-{"Acute kidney injury": 3.534002050770199, "Angioedema": 7.539282653142957, "Drug ineffective for unapproved indication": 20.73629511858232, "Drug interaction": 16.028467435603925, "Liver transplant rejection": 340.61135450972023, "Off label use": 3.728950871336153, "Product use in unapproved indication": 8.56891060528179, "Transplant rejection": 68.93462089310147}
+{"adverse drug reaction": 2.95, "adverse event": 29.18, "alanine aminotransferase increased": 5.62, "anaemia": 7.82, "ascites": 5.2, "aspartate aminotransferase increased": 4.8, "asthenia": 2.02, "blood alkaline phosphatase increased": 2.36, "blood creatinine increased": 8.76, "blood magnesium decreased": 33.47, "blood potassium decreased": 5.63, "blood test abnormal": 10.0, "carbohydrate antigen 125 increased": 764.29, "constipation": 5.2, "death": 3.73, "decreased appetite": 2.88, "dehydration": 5.03, "drug intolerance": 3.94, "dysgeusia": 6.48, "full blood count abnormal": 21.45, "haematocrit decreased": 5.88, "haemoglobin decreased": 8.95, "hepatic enzyme increased": 2.16, "hypophagia": 11.07, "intestinal obstruction": 14.2, "laboratory test abnormal": 14.03, "liver function test abnormal": 3.01, "liver function test increased": 6.69, "maligt neoplasm progression": 18.48, "metastases to central nervous system": 7.32, "myelodysplastic syndrome": 8.14, "neuropathy peripheral": 4.48, "neutropenia": 2.22, "ovarian cancer recurrent": 610.67, "photosensitivity reaction": 5.63, "platelet count decreased": 9.12, "prescribed underdose": 14.06, "product dose omission issue": 8.0, "product use in unapproved indication": 2.07, "recurrent cancer": 39.82, "red blood cell count decreased": 20.12, "renal function test abnormal": 30.16, "renal impairment": 2.72, "small intestinal obstruction": 26.32, "surgery": 3.66, "taste disorder": 4.81, "therapy partial responder": 16.51, "thrombocytopenia": 4.43, "transfusion": 7.89, "tumour marker increased": 26.7, "underdose": 9.67, "urinary tract infection": 2.06, "white blood cell count decreased": 4.9}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1003.json

@@ -1 +1 @@
-{"Alanine aminotransferase increased": 4.805884049268032, "Anaemia": 3.8919569772032, "Aspartate aminotransferase increased": 4.228994240474632, "Blood potassium decreased": 18.92882110415466, "Death": 2.4279047452921247, "Drug-induced liver injury": 11.672797761891626, "Electrocardiogram QT prolonged": 112.0765038457217, "Haemoglobin decreased": 2.7795116537951228, "Hepatic function abnormal": 4.097208895425196, "Hypokalaemia": 3.030467415493918, "Intentional product use issue": 20.168822450481315, "Liver injury": 12.052242875590746, "Neuropathy peripheral": 7.837996165019741, "Off label use": 5.954478088971817, "Product use issue": 5.170778410045484, "Pulmonary tuberculosis": 70.57367086101097, "Rash pruritic": 3.546455720479756, "Respiratory failure": 11.78429460621224}
+{"central venous catheterisation": 137.85, "condition aggravated": 4.87, "device related infection": 25.3, "drug ineffective": 3.83, "drug ineffective for unapproved indication": 27.31, "hereditary angioedema": 308.67, "illness": 2.16, "infection": 2.42, "intentional product use issue": 75.87, "kidney infection": 15.0, "laryngeal oedema": 12.51, "maternal exposure during breast feeding": 12.64, "maternal exposure during pregcy": 11.54, "nephrolithiasis": 8.33, "pharyngeal swelling": 109.84, "pneumonia": 2.83, "product dose omission issue": 5.27, "product use in unapproved indication": 9.86, "respiratory tract oedema": 210.82, "sepsis": 5.24, "sinusitis": 6.46, "therapeutic product effect incomplete": 20.46, "thrombosis": 5.27, "underdose": 17.28, "vascular access complication": 934.29, "vascular access site complication": 8914.86, "vascular device infection": 38.85}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1004.json

@@ -1 +1 @@
-{"Acute kidney injury": 2.587392476279438, "Angioedema": 3.835539714065976, "Atrial fibrillation": 3.154099036720609, "Blood glucose increased": 2.143764055540013, "Completed suicide": 19.66567288460777, "Diabetes mellitus": 7.759073765927343, "Diabetes mellitus inadequate control": 24.894974495762845, "Drug interaction": 3.1260122672941804, "Hyperkalaemia": 6.013446941180351, "Hypoglycaemia": 13.789757839468932, "Infusion site extravasation": 175.88972800076286, "Lactic acidosis": 21.52830886033204, "Loss of consciousness": 2.3881972117019874, "Pemphigoid": 36.49822139696445, "Product monitoring error": 290.8439585151044, "Toxicity to various agents": 5.338830471858231, "Tremor": 2.0420126053534013, "Wrong patient received product": 94.19399297381086}
+{"seizure": 19.09}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1005.json

@@ -1 +1 @@
-{}
+{"antineutrophil cytoplasmic antibody positive": 35.41, "bacterial infection": 3.9, "blood pressure diastolic decreased": 22.38, "blood pressure fluctuation": 41.01, "blood pressure increased": 4.79, "blood pressure systolic increased": 27.87, "body temperature decreased": 7.92, "body temperature fluctuation": 10.24, "c-reactive protein increased": 4.42, "cataract": 4.35, "condition aggravated": 7.65, "cough": 2.25, "covid-19": 2.13, "covid-19 pneumonia": 5.06, "cyst": 4.32, "cystitis": 3.67, "drug effective for unapproved indication": 18.86, "drug ineffective for unapproved indication": 2.95, "dry throat": 3.9, "ear discomfort": 2.66, "ear infection": 3.45, "ear pruritus": 106.56, "eye disorder": 3.57, "eye infection": 4.71, "eye pruritus": 2.6, "flushing": 2.88, "foot deformity": 4.7, "heart rate decreased": 8.72, "heart rate increased": 2.48, "heart rate irregular": 11.33, "hernia": 2.97, "hip arthroplasty": 4.04, "hypertension": 2.75, "illness": 3.09, "immunodeficiency": 3.31, "immunosuppression": 5.96, "inappropriate schedule of product administration": 8.79, "incorrect product administration duration": 13.12, "infection": 3.18, "infusion related reaction": 6.52, "infusion site extravasation": 16.35, "infusion site pain": 7.23, "infusion site swelling": 11.16, "intentional product use issue": 50.62, "joint injury": 6.33, "joint swelling": 2.29, "knee arthroplasty": 3.66, "knee operation": 5.13, "lacrimation increased": 2.26, "limb injury": 4.85, "localised infection": 5.78, "loss of personal independence in daily activities": 2.8, "lower respiratory tract infection": 4.27, "lung disorder": 3.94, "nasal congestion": 3.61, "nasopharyngitis": 3.89, "off label use": 14.89, "oral pruritus": 5.18, "oropharyngeal discomfort": 3.68, "oropharyngeal pain": 2.29, "oxygen saturation decreased": 4.74, "pharyngeal paraesthesia": 22.95, "pharyngeal swelling": 2.74, "pneumonia": 3.01, "pneumonia bacterial": 7.04, "poor venous access": 75.08, "product use issue": 9.65, "productive cough": 3.12, "pulmonary fibrosis": 3.67, "red blood cell sedimentation rate increased": 3.01, "renal disorder": 2.83, "respiratory rate increased": 3.15, "rheumatoid arthritis": 5.19, "rhinorrhoea": 3.04, "sinus disorder": 4.23, "sinusitis": 4.32, "sinusitis bacterial": 51.54, "stress": 2.0, "synovitis": 5.37, "systemic lupus erythematosus": 2.36, "therapeutic product effect incomplete": 3.37, "therapeutic response shortened": 38.25, "throat irritation": 22.77, "throat tightness": 5.83, "tongue pruritus": 9.95, "tooth disorder": 4.77, "tooth extraction": 8.1, "tooth infection": 4.69, "upper limb fracture": 2.38, "vasculitis": 2.84, "viral infection": 2.89, "weight increased": 2.4, "wound": 2.5, "wrist fracture": 3.62}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1006.json

@@ -1 +1 @@
-{"Completed suicide": 102.5292937671624, "Intentional product misuse": 101.95006512172726, "Toxicity to various agents": 89.14388211807089}
+{"acute graft versus host disease": 14.17, "acute myeloid leukaemia": 18.92, "alanine aminotransferase increased": 2.18, "anaemia": 13.4, "basal cell carcinoma": 19.78, "bk virus infection": 29.91, "blood lactate dehydrogenase increased": 6.47, "bone pain": 2.14, "c-reactive protein increased": 2.53, "chronic graft versus host disease": 33.4, "concomitant disease aggravated": 10.05, "cytomegalovirus infection": 18.89, "cytomegalovirus infection reactivation": 38.83, "cytopenia": 29.32, "disease recurrence": 4.32, "epstein-barr virus infection reactivation": 43.62, "graft versus host disease": 9.06, "haematocrit decreased": 11.09, "haemoglobin abnormal": 24.3, "haemoglobin decreased": 14.23, "infection": 2.58, "leukocytosis": 21.75, "leukopenia": 2.83, "lymphopenia": 4.65, "maligt neoplasm progression": 3.23, "multiple organ dysfunction syndrome": 2.41, "myelofibrosis": 178.01, "neutrophil count increased": 20.81, "night sweats": 3.18, "pancytopenia": 3.67, "platelet count abnormal": 45.03, "platelet count decreased": 11.56, "platelet count increased": 30.72, "pneumonia": 2.19, "primary myelofibrosis": 656.26, "product use in unapproved indication": 16.4, "product use issue": 2.75, "pulmonary tuberculosis": 22.61, "red blood cell count decreased": 5.54, "respiratory failure": 2.65, "second primary maligcy": 168.74, "sepsis": 3.49, "septic shock": 2.53, "skin lesion": 2.75, "spleen disorder": 59.09, "splenomegaly": 108.66, "squamous cell carcinoma": 61.6, "squamous cell carcinoma of skin": 62.11, "therapeutic response decreased": 8.88, "therapy non-responder": 10.6, "therapy partial responder": 28.35, "thrombocytopenia": 12.64, "thrombocytosis": 31.3, "tuberculosis": 13.86, "weight increased": 2.64, "white blood cell count decreased": 2.2, "white blood cell count increased": 14.48, "withdrawal syndrome": 2.38}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1007.json

@@ -1 +1 @@
-{"Abortion spontaneous": 2.653979182249274, "Acne": 2.971094238981685, "Arthritis": 2.6536412187940126, "Breast cancer": 2.2343051311679014, "Breast cancer female": 20.27669792555257, "C-reactive protein increased": 2.1787978560301577, "Crohn's disease": 4.497658652437914, "Dermatitis exfoliative generalised": 7.177791313020195, "Device issue": 13.528436062341603, "Eczema": 4.999146028610052, "Fungal infection": 4.237620919927919, "Hepatic cirrhosis": 5.020717179041319, "Infection": 2.071359809157869, "Injection site haemorrhage": 7.483320503453508, "Intestinal obstruction": 4.3474030201401, "Lung neoplasm malignant": 3.078402096828841, "Lymphoma": 9.180553763851163, "Maternal exposure during pregnancy": 2.2818829700024037, "Prostate cancer": 4.400558744395312, "Psoriasis": 52.66322628834445, "Psoriatic arthropathy": 11.409406826006387, "Skin disorder": 2.8866871735501904, "Skin exfoliation": 4.713151523368958, "Skin lesion": 3.21380542299721, "Skin plaque": 19.343395065319918, "Stress": 2.83542321950803, "Surgery": 3.848365977664933, "Therapeutic product effect decreased": 3.2939890061616617, "Therapeutic product effect incomplete": 2.7337508623495435, "Therapeutic response shortened": 64.98127031151897, "Tuberculosis": 6.911136707464373, "Unevaluable event": 14.622455339714728}
+{"abdominal discomfort": 6.62, "abdominal distension": 6.89, "abdominal pain": 3.1, "abdominal pain upper": 5.53, "acute kidney injury": 2.2, "amylase increased": 6.09, "blood glucose decreased": 2.54, "blood glucose increased": 6.58, "cholecystitis": 8.78, "cholelithiasis": 12.61, "constipation": 7.65, "decreased appetite": 4.65, "dehydration": 3.85, "diabetes mellitus inadequate control": 8.44, "diabetic ketoacidosis": 3.76, "diarrhoea": 3.43, "drug intolerance": 4.17, "dysgeusia": 3.4, "dyspepsia": 9.91, "eructation": 33.76, "feeding disorder": 3.2, "flatulence": 11.55, "gastritis": 3.61, "gastrointestinal disorder": 7.19, "gastrooesophageal reflux disease": 4.57, "glycosylated haemoglobin increased": 28.96, "hyperglycaemia": 2.16, "impaired gastric emptying": 30.92, "inappropriate schedule of product administration": 3.1, "increased appetite": 8.22, "intestinal obstruction": 3.83, "lipase increased": 9.59, "nausea": 4.29, "off label use": 3.56, "pancreatitis": 20.46, "pancreatitis acute": 14.06, "product taste abnormal": 6.16, "surgery": 2.6, "taste disorder": 3.31, "vomiting": 5.29, "weight decreased": 4.84, "weight increased": 2.39}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1008.json

@@ -1 +1 @@
-{"Aggression": 75.87874501894635, "Agitation": 33.4324342605909, "Irritability": 30.746272970693337, "Middle insomnia": 108.16237748116951, "Product administered to patient of inappropriate age": 129.40971429495238, "Somnolence": 3.3420154094123924}
+{"dermatitis acneiform": 149.74, "disease progression": 5.85, "infusion related reaction": 161.42, "non-small cell lung cancer": 281.65, "non-small cell lung cancer metastatic": 1740.17, "paronychia": 418.23, "pneumonitis": 19.99, "rash": 4.77, "skin toxicity": 153.03}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1009.json

@@ -1 +1 @@
-{"Ammonia increased": 85.14768935177429, "Cardiac arrest": 5.691845298571863, "Cerebrovascular insufficiency": 1687.92266617122, "Cluster headache": 93.0829645908044, "Coma": 7.077070081568211, "Confusional state": 4.934083684780522, "Drug abuse": 8.448666755634182, "Drug interaction": 14.412439204413706, "Drug level increased": 21.253946300848245, "Electroencephalogram abnormal": 87.68644476337025, "Eye movement disorder": 46.17764180242136, "Inhibitory drug interaction": 199.73286981245587, "Miosis": 51.29912456556964, "Multiple organ dysfunction syndrome": 10.636908014887943, "Myoclonus": 24.15322610955697, "Overdose": 17.66334240346588, "Somnolence": 3.1921201048783825, "Toxicity to various agents": 19.5116998130631}
+{"acute myeloid leukaemia": 25.07, "acute myeloid leukaemia recurrent": 173.5, "cardiac failure": 4.53, "cytopenia": 31.69, "death": 2.81, "diarrhoea": 2.0, "dysphagia": 4.23, "electrocardiogram qt prolonged": 9.42, "febrile neutropenia": 11.32, "maligt neoplasm progression": 3.47, "neutropenia": 2.81, "platelet count decreased": 2.95, "sepsis": 4.88, "thrombocytopenia": 3.98}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/101.json

@@ -1 +1 @@
-{"Pyrexia": 2.4572270141847503}
+{"face oedema": 50.2}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1010.json

@@ -1 +1 @@
-{"Anaemia": 2.415525757893432, "Ascites": 5.870984986841708, "Bradycardia": 8.356390750732139, "Death": 2.2323323476761026, "Drug ineffective": 5.700401037500559, "Drug interaction": 4.796295965875079, "Genotype drug resistance test positive": 117.6370637123594, "Hepatitis C": 72.37544742557667, "Hepatocellular carcinoma": 23.772727215694548, "Intentional dose omission": 99.27973837023455, "Product dose omission issue": 6.241568586349409, "Treatment failure": 27.035609476735512}
+{"alopecia": 11.25, "amenorrhoea": 21.14, "condition aggravated": 6.42, "depressed mood": 7.01, "depression": 4.27, "heavy menstrual bleeding": 16.14, "hot flush": 16.39, "intermenstrual bleeding": 20.57, "irritability": 6.12, "mood swings": 15.42, "uterine haemorrhage": 190.31, "uterine leiomyoma": 93.69, "vaginal haemorrhage": 10.95, "weight increased": 7.79}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1012.json

@@ -1 +1 @@
-{"Abscess limb": 27.31409671249371, "Acne": 3.2689167459726987, "Apnoea": 12.316305373243914, "Autoimmune thyroiditis": 14.285540665721554, "Blood alkaline phosphatase increased": 3.775187826782616, "Blood follicle stimulating hormone increased": 128.62945455890866, "Brain neoplasm": 32.95469153570535, "Cerebral infarction": 3.2111979663106425, "Condition aggravated": 2.159508749101408, "Contusion": 3.217902387412193, "Craniopharyngioma": 626.4802843396005, "Dehydration": 3.0904776507878875, "Diabetes mellitus": 5.843430255987122, "Disease recurrence": 10.460935280923849, "Drug abuse": 4.682739818575517, "Drug-induced liver injury": 10.747336530746834, "Eating disorder": 4.873289348430135, "Electrolyte imbalance": 9.670530122271732, "Enteritis": 18.699391002719537, "Epiphysiolysis": 722.4450930132522, "Fluid retention": 3.469666284043281, "Focal nodular hyperplasia": 148.3289695208738, "Focal segmental glomerulosclerosis": 77.75742512517103, "Gastrointestinal infection": 38.17183352978912, "Glucose tolerance impaired": 68.31341766630216, "Glycosylated haemoglobin increased": 3.522666981774041, "Head injury": 4.360510550601289, "Hepatic cirrhosis": 26.67277078647569, "Hepatic encephalopathy": 44.40357586596575, "Hepatic necrosis": 118.82859525466692, "Hepatomegaly": 11.912783809452428, "Hepatotoxicity": 13.493550296518764, "Hypoglycaemia": 2.576591646842401, "Hyponatraemic seizure": 386.1438015596223, "Hypophagia": 6.471100344467632, "Idiopathic intracranial hypertension": 241.6653602346964, "Increased appetite": 10.64671010133172, "Injection site atrophy": 88.83987535467666, "Injection site bruising": 10.547298936069764, "Injection site haemorrhage": 9.86754881187074, "Insulin resistance": 35.62490278094377, "Insulin-like growth factor increased": 278.57056558083264, "Intentional product misuse": 2.0170800566277776, "Intracranial pressure increased": 58.61924593764471, "Lower limb fracture": 9.307119250187409, "Meningioma": 56.60556288884906, "Myocardial fibrosis": 99.93713553370924, "Neoplasm recurrence": 93.530186464796, "Obstructive sleep apnoea syndrome": 93.44473712164935, "Oesophageal disorder": 49.96482074252936, "Off label use": 3.0642471280183825, "Pancreatitis acute": 6.354695258301056, "Panniculitis": 25.471415284247072, "Papilloedema": 23.66846701604428, "Pituitary tumour benign": 63.016160763225535, "Pleural adhesion": 349.2422085660759, "Product dose omission issue": 2.4982479017417747, "Product prescribing error": 10.437622371213305, "Protein-losing gastroenteropathy": 185.394968085309, "Scoliosis": 87.56623486100816, "Sleep apnoea syndrome": 37.13542725004547, "Snoring": 88.88864192627597, "Stress": 2.4625437485970263, "Sudden death": 18.379653723577015, "Sulphaemoglobinaemia": 1290.8221809123604, "Therapeutic response unexpected": 3.0383413805651585, "Tonsillar disorder": 271.355272624483, "Type 1 diabetes mellitus": 7.415810809777687, "Type 2 diabetes mellitus": 6.847951891042719, "Viral infection": 4.7167327495039295}
+{"alopecia": 13.65, "asthenia": 3.33, "constipation": 5.81, "diarrhoea": 6.43, "disease progression": 6.79, "febrile neutropenia": 10.18, "inappropriate schedule of product administration": 4.52, "neutropenia": 22.7}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1013.json

@@ -1 +1 @@
-{"Acromegaly": 1167.8586757180838, "Arterial occlusive disease": 61.40886252165932, "Blood cholesterol abnormal": 125.68558345530217, "Blood growth hormone increased": 1567.6136640463608, "Blood pressure increased": 2.6867497856468776, "Bradycardia": 8.070330517226365, "Cellulitis": 10.484020847367836, "Chest discomfort": 3.04205091747726, "Drug hypersensitivity": 6.223032204913022, "Drug intolerance": 7.66977011149899, "Fall": 2.4860273494299947, "Gait disturbance": 3.142575354991156, "Goitre": 97.82226335142823, "Heart rate decreased": 15.84040714212818, "Hypersensitivity": 4.052739252482582, "Inappropriate schedule of product administration": 7.913379590326489, "Incorrect route of product administration": 16.851669547281585, "Injection site bruising": 42.68564604487056, "Injection site oedema": 48.44739766612511, "Injection site pain": 2.163032452951404, "Insulin-like growth factor increased": 2152.5677485815067, "Limb injury": 28.849978134739857, "Peripheral swelling": 2.480743531082287, "Polyp": 126.81002671235574, "Pulmonary embolism": 5.5440660845432586, "Syringe issue": 158.79809861795198, "Tendonitis": 21.905398881491408, "Vital functions abnormal": 721.8178136516517, "Weight decreased": 2.1154762204860043, "Wound infection": 82.84083206435105}
+{"dyskinesia": 69.81, "hallucination": 30.95}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1014.json

@@ -1 +1 @@
-{"Intentional overdose": 36.05160301566608}
+{"adverse event": 2.18, "alanine aminotransferase increased": 2.48, "altered state of consciousness": 9.82, "anuria": 6.49, "aspartate aminotransferase increased": 3.35, "blood alkaline phosphatase increased": 3.26, "blood bilirubin increased": 5.58, "blood creatinine increased": 6.24, "blood potassium decreased": 5.48, "blood potassium increased": 20.13, "blood pressure decreased": 3.89, "blood sodium abnormal": 104.28, "blood sodium decreased": 89.6, "blood sodium increased": 395.86, "blood urea increased": 21.4, "cardiac failure": 10.14, "cardiac failure chronic": 17.63, "cardiac failure congestive": 2.17, "cerebral infarction": 6.13, "death": 5.24, "dehydration": 11.66, "delirium": 2.31, "depressed level of consciousness": 2.69, "disseminated intravascular coagulation": 7.1, "drug-induced liver injury": 3.8, "eosinophil count increased": 11.16, "gamma-glutamyltransferase increased": 2.62, "glomerular filtration rate decreased": 8.21, "hepatic cirrhosis": 6.94, "hepatic encephalopathy": 46.37, "hepatic failure": 5.49, "hepatic function abnormal": 20.42, "hospice care": 24.97, "hospitalisation": 10.73, "hyperkalaemia": 6.9, "hypernatraemia": 534.73, "hyponatraemia": 8.67, "inability to afford medication": 46.89, "inappropriate schedule of product administration": 11.02, "incorrect dose administered": 2.26, "incorrect drug administration rate": 37.98, "incorrect product administration duration": 58.69, "incorrect route of product administration": 4.64, "insurance issue": 31.17, "liver disorder": 10.14, "liver function test abnormal": 2.17, "mental status changes": 3.99, "multiple organ dysfunction syndrome": 3.74, "no adverse event": 3.26, "off label use": 2.25, "osmotic demyelination syndrome": 292.21, "pancytopenia": 2.78, "platelet count decreased": 3.37, "pleural effusion": 2.07, "pneumonia aspiration": 3.77, "pollakiuria": 2.38, "polyuria": 22.26, "prescribed underdose": 11.78, "product dose omission issue": 2.98, "product use in unapproved indication": 8.12, "rapid correction of hyponatraemia": 23828.04, "renal disorder": 2.68, "renal impairment": 10.8, "shock": 2.88, "therapy interrupted": 5.59, "thirst": 17.05, "underdose": 26.9, "urine output decreased": 6.73, "urine output increased": 32.86, "wrong technique in product usage process": 18.8}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1015.json

@@ -1 +1 @@
-{"Alpha 1 foetoprotein increased": 117.58745308698218, "Ascites": 5.550053398271658, "Blister": 3.4120996548188627, "Diarrhoea": 3.3407404264033818, "Disease progression": 5.839117538334553, "Drug ineffective for unapproved indication": 6.258355117317848, "Erythema multiforme": 5.510979238909851, "Haematotoxicity": 11.741519357162655, "Hepatic encephalopathy": 10.293247755647284, "Hepatic failure": 6.0591430036270655, "Hepatocellular carcinoma": 45.14421136202953, "Hepatotoxicity": 5.478867204588851, "Hyperkeratosis": 18.3733643542266, "Hypertension": 3.013407366915988, "Hypocalcaemia": 9.6470695970997, "International normalised ratio increased": 2.1038195462158686, "Malignant neoplasm progression": 2.809789132493224, "Metastases to adrenals": 69.905760963194, "Metastases to bone": 8.459648334480317, "Metastases to liver": 6.502514645388471, "Metastases to lung": 30.543054872294285, "Metastatic renal cell carcinoma": 30.86796027671447, "Mucosal inflammation": 8.28979992726653, "Neoplasm progression": 3.452534897166229, "Off label use": 5.293977606675179, "Osteonecrosis of jaw": 14.70981260897226, "Palmar-plantar erythrodysaesthesia syndrome": 71.92652538146406, "Product use in unapproved indication": 7.835363440653246, "Rash maculo-papular": 2.776626436271433, "Renal cell carcinoma": 15.910019249109528, "Skin exfoliation": 2.8192660283382813, "Skin reaction": 4.758319618050393, "Skin toxicity": 48.99359915368554, "Skin ulcer": 6.50701368486814, "Squamous cell carcinoma of skin": 28.353003645537928, "Stevens-Johnson syndrome": 4.156051349482739, "Thrombocytopenia": 3.780902588912728, "Tumour lysis syndrome": 15.731632606322991, "Weight decreased": 2.306152531961974}
+{"nausea": 2.76, "product adhesion issue": 241.79, "vomiting": 2.56}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1016.json

@@ -1 +1 @@
-{"Alanine aminotransferase increased": 10.805313105473848, "Aspartate aminotransferase increased": 9.902324177422711, "Blood bilirubin increased": 9.164748462552684, "Diarrhoea": 5.963941289679823, "Disease progression": 10.689063711986478, "Drug-induced liver injury": 10.625166862238151, "Hepatic enzyme increased": 5.34836961827246, "Hepatic function abnormal": 9.268010685628123, "Hepatotoxicity": 44.974335675532025, "Liver disorder": 6.937692081216955, "Liver function test increased": 17.2586945444678, "Lung adenocarcinoma": 136.47393837646254, "Lung neoplasm malignant": 12.518128619614066, "Non-small cell lung cancer": 917.6710243441228, "Non-small cell lung cancer metastatic": 2736.759079656651, "Off label use": 2.092671466661886, "Therapy partial responder": 73.56637711356981}
+{"anaphylactic reaction": 3.69, "herpes zoster": 7.71, "hypersensitivity": 2.72}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1017.json

@@ -1 +1 @@
-{"Altered state of consciousness": 2.024050394367631, "Ammonia increased": 7.394131877404162, "Anaemia": 8.55958588248953, "Ascites": 9.094616982559542, "Atrial septal defect": 6.304609474381127, "Autoimmune hepatitis": 4.34647692809549, "Blood bilirubin increased": 7.412695506256812, "Cerebral haemorrhage": 2.4261612946622457, "Cerebral infarction": 3.809744463535769, "Colitis ischaemic": 5.542067546483547, "Death": 2.0131114079317567, "Depression": 2.201360839632474, "Disseminated intravascular coagulation": 2.2543983797041407, "Drug ineffective": 9.32907426444314, "Genotype drug resistance test positive": 15.422815593871432, "Glomerular filtration rate decreased": 4.504709760160125, "Haematemesis": 3.0708755356390083, "Haemoglobin decreased": 8.082692589051026, "Haemolytic anaemia": 12.313385417004216, "Hepatic cancer": 14.629033122198743, "Hepatic cancer recurrent": 602.0039890255414, "Hepatic cirrhosis": 22.786745654044303, "Hepatic encephalopathy": 28.74600624895768, "Hepatic failure": 5.931417114939051, "Hepatic fibrosis": 12.041285487330828, "Hepatitis": 3.55365924842276, "Hepatitis B reactivation": 24.750836315201404, "Hepatitis C": 140.67988130454347, "Hepatitis C RNA increased": 76.9606002229754, "Hepatitis C RNA positive": 259.072465501785, "Hepatitis C virus test positive": 55.05430937726681, "Hepatocellular carcinoma": 48.2368636220552, "Hepatorenal syndrome": 16.059846038349804, "Hyperbilirubinaemia": 19.273544181611605, "Incorrect product administration duration": 6.3377282494176175, "Infection reactivation": 75.01193638089899, "Jaundice": 7.378857502671108, "Loss of consciousness": 2.441367856446145, "Lung neoplasm malignant": 2.0633085005915626, "Lymphoma": 6.231909913666382, "Mood swings": 2.400183233757752, "Multiple organ dysfunction syndrome": 2.8095887428918456, "Neoplasm malignant": 2.3829166882263846, "Oedema peripheral": 2.31561556491414, "Oesophageal varices haemorrhage": 38.12947358924573, "Pancreatitis acute": 2.857094945402418, "Photosensitivity reaction": 2.332324622538988, "Portal vein thrombosis": 15.421635932283817, "Product complaint": 2.159330908377829, "Renal impairment": 4.034343000103323, "Septic shock": 3.187501681052547, "Spontaneous bacterial peritonitis": 47.82313725936973, "Treatment failure": 15.409961112093988, "Treatment noncompliance": 3.1921722220004702, "Unevaluable event": 2.45048167784442, "Upper gastrointestinal haemorrhage": 2.0939908122346926, "Viral load increased": 23.913711484866848, "Virologic failure": 24.4060372416836}
+{"anaemia": 4.07, "disease progression": 14.74, "dyspnoea": 2.96, "infection": 8.07, "infusion related reaction": 88.39, "neutropenia": 12.18, "pneumonia": 5.42, "thrombocytopenia": 4.9}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1018.json

@@ -1 +1 @@
-{"Pancreatitis acute": 73.61796610087383}
+{"drug ineffective": 2.41, "neutropenia": 18.07}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1021.json

@@ -1 +1 @@
-{"Acute generalised exanthematous pustulosis": 11.069981200907966, "Acute kidney injury": 8.417079097333714, "Aortic valve incompetence": 11.26172231608694, "Ascites": 2.1123389108606587, "Asthenia": 3.96594204412715, "Atrial fibrillation": 2.969582946995795, "Atrioventricular block first degree": 35.271465129672414, "Blood bicarbonate decreased": 18.98393803184759, "Blood creatinine increased": 4.858174509291004, "Blood potassium decreased": 6.036230065080136, "Blood potassium increased": 16.08439894050272, "Blood urea increased": 7.34362224347695, "Bradycardia": 4.585396047739196, "Bradykinesia": 10.960219120471624, "Bundle branch block left": 23.00134101042033, "Cardiac amyloidosis": 112.57641288607954, "Cardiac failure": 3.63413761650154, "Cardiac failure acute": 7.207733421182305, "Cardiac failure chronic": 15.211152678003312, "Cardioactive drug level increased": 11.757587920623507, "Cardiomegaly": 4.050939879640464, "Coagulopathy": 4.444699785685563, "Cognitive disorder": 3.053589141704128, "Coronary artery disease": 2.1205898927138405, "Dehydration": 4.62973990273559, "Dementia": 5.34235615452441, "Drug interaction": 3.2489091043062786, "Drug reaction with eosinophilia and systemic symptoms": 6.398986065335149, "Dyspnoea at rest": 14.06076764485153, "Dysuria": 3.1565959007118662, "Electrocardiogram QRS complex prolonged": 22.59997050775363, "Electrocardiogram QT prolonged": 2.031898119005041, "Electrocardiogram T wave peaked": 125.89105712044372, "Electrocardiogram abnormal": 6.037101156183706, "Electrolyte imbalance": 4.820860539541292, "Exercise tolerance decreased": 3.2828705842567687, "Fall": 2.820583647911803, "Fluid retention": 2.7106136534104337, "Gastric polyps": 23.02311044271998, "Glomerular filtration rate decreased": 3.4408901559498477, "Gynaecomastia": 15.513178101531572, "Haematuria": 2.500963812934925, "Heart failure with reduced ejection fraction": 91.6063468955274, "Hiatus hernia": 9.260051774443756, "Hyperkalaemia": 53.25643824405956, "Hypokalaemia": 4.435649942474549, "Hyponatraemia": 10.747136368819334, "Hypophagia": 3.998935340894473, "Hypotension": 5.581615426928849, "Hypovolaemia": 15.790695183996773, "Left ventricular dysfunction": 7.437639440475072, "Medication error": 3.733613773771204, "Metabolic acidosis": 8.099474746460112, "Mitral valve incompetence": 6.87789401907722, "Mobility decreased": 2.238993735330338, "Motor dysfunction": 9.757556232852007, "Multiple organ dysfunction syndrome": 2.988094860664582, "Muscular weakness": 2.532788072135145, "Neuroglycopenia": 249.2446564928584, "Obstructive pancreatitis": 53.390195120476776, "Oedema peripheral": 3.8156087003344368, "Oliguria": 5.317271328580789, "Orthostatic hypotension": 11.740996879867712, "Parkinsonism": 9.590956800928131, "Premature delivery": 3.4885240994097573, "Product prescribing error": 2.581164084378152, "Pulmonary congestion": 5.502253863263049, "Pulmonary oedema": 2.291952274525096, "Rales": 6.715525512405667, "Renal impairment": 2.70428678288886, "Sedation": 2.249928136106992, "Sinus bradycardia": 9.197482761365116, "Stevens-Johnson syndrome": 12.222780166169269, "Tachypnoea": 2.354324392724259, "Toxic epidermal necrolysis": 2.256699705217657, "Transplant dysfunction": 57.04879384223173, "Type 2 diabetes mellitus": 2.372373180506174, "Urine output decreased": 5.1962731173255845, "Ventricular extrasystoles": 3.74426204197182, "Ventricular tachycardia": 5.602339938636116}
+{"abdominal discomfort": 2.16, "abdominal distension": 6.09, "abdominal pain": 3.21, "abdominal pain upper": 3.66, "abortion spontaneous": 2.09, "amylase increased": 6.56, "appendicitis": 3.89, "appetite disorder": 26.03, "biliary colic": 38.71, "cholecystectomy": 26.72, "cholecystitis": 32.76, "cholecystitis acute": 15.0, "cholelithiasis": 51.67, "constipation": 8.67, "dehydration": 3.75, "depressed mood": 2.03, "depressive symptom": 6.53, "device delivery system issue": 7.43, "device failure": 3.28, "device issue": 2.54, "device malfunction": 4.32, "diarrhoea": 2.87, "diarrhoea haemorrhagic": 2.81, "disability": 2.5, "discomfort": 2.19, "diverticulitis": 3.8, "drug dose titration not performed": 52.62, "drug effect less than expected": 9.91, "dry mouth": 2.39, "dyspepsia": 8.58, "eructation": 38.95, "flatulence": 7.93, "food craving": 60.16, "gallbladder disorder": 7.35, "gastritis": 6.93, "gastroenteritis": 4.2, "gastrooesophageal reflux disease": 5.75, "hepatic steatosis": 3.21, "hunger": 36.14, "hypoglycaemic unconsciousness": 4.02, "impaired gastric emptying": 8.64, "inappropriate schedule of product administration": 3.11, "incorrect dose administered by device": 6.74, "increased appetite": 14.42, "injection site bruising": 15.83, "injection site discolouration": 20.0, "injection site erythema": 7.55, "injection site haematoma": 2.27, "injection site hypersensitivity": 63.85, "injection site induration": 3.96, "injection site irritation": 34.19, "injection site mass": 9.08, "injection site pruritus": 16.23, "injection site rash": 38.59, "injection site reaction": 2.28, "injection site swelling": 2.12, "injection site urticaria": 34.33, "intestinal obstruction": 2.58, "lack of satiety": 230.78, "lipase increased": 14.14, "liquid product physical issue": 6.26, "liver function test increased": 2.01, "maternal exposure during pregcy": 2.26, "nausea": 3.26, "nephrolithiasis": 2.67, "pancreatitis": 27.19, "pancreatitis acute": 11.82, "pancreatitis necrotising": 10.93, "papillary thyroid cancer": 19.89, "prescription drug used without a prescription": 8.72, "product quality issue": 4.5, "product storage error": 2.24, "suicidal ideation": 3.95, "surgery": 4.35, "suspected counterfeit product": 7.48, "therapeutic product effect decreased": 2.13, "thyroid cancer": 2.96, "thyroid mass": 16.42, "vomiting": 3.6, "weight increased": 4.1, "weight loss poor": 719.29, "wrong technique in product usage process": 2.68}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1022.json

@@ -1 +1 @@
-{"Acne": 2.893460566737926, "Acute febrile neutrophilic dermatosis": 6.632525313926249, "Acute lymphocytic leukaemia recurrent": 15.998468666897082, "Acute pulmonary oedema": 4.701705370095726, "Adverse event": 11.49143040148586, "Anaemia": 2.383820857328499, "Ascites": 2.69201418445554, "Aspiration pleural cavity": 197.07918646215867, "Atrial fibrillation": 2.229157145126877, "Back disorder": 2.271186757345953, "Blast cell crisis": 109.189024914848, "Blast cell proliferation": 220.8747091943709, "Blast crisis in myelogenous leukaemia": 48.85539172091863, "Blood disorder": 5.009976933338447, "Bone marrow disorder": 24.010438561433023, "Bone marrow failure": 4.064937760298294, "Bone marrow transplant": 57.56143589411527, "Bone pain": 2.4036667824711304, "Cardiac disorder": 2.8228808922218303, "Cardiac failure": 4.093204463628765, "Cardiac failure congestive": 4.367598778334342, "Cardiomegaly": 2.341395871867739, "Cellulitis": 2.1109676609757853, "Chronic myeloid leukaemia": 31.66536682013635, "Chronic myeloid leukaemia recurrent": 67.67375155388085, "Chronic myeloid leukaemia transformation": 63.31810231488716, "Chylothorax": 246.3563302740834, "Clostridium difficile infection": 2.301920483489054, "Colitis": 5.14594226288751, "Cytomegalovirus colitis": 7.744914990893187, "Cytomegalovirus enterocolitis": 20.09020762833893, "Cytopenia": 14.179689451583016, "Death": 3.09455298187857, "Dialysis": 2.040094019183029, "Drug resistance": 2.3760629427418105, "Dyspnoea exertional": 2.16250888703444, "Electrocardiogram QT prolonged": 3.0042365483041027, "Enterocolitis": 4.006317435139912, "Enterocolitis haemorrhagic": 17.93716725282123, "Eye haemorrhage": 2.0008541084455365, "Fluid retention": 13.005368334440652, "Full blood count decreased": 12.55605821348726, "Gallbladder disorder": 2.766055353890416, "Gastrointestinal haemorrhage": 3.396288063688648, "Gastrointestinal infection": 3.6992038061813335, "Gene mutation": 30.12755491850753, "Generalised oedema": 3.0215952709851184, "Graft versus host disease": 4.341178167173663, "Haematochezia": 2.255193461066019, "Haematotoxicity": 4.18158776538611, "Haemorrhage": 2.1732486015628365, "Haemothorax": 9.277347037846702, "Hospitalisation": 12.142961245391785, "Intentional product use issue": 4.016194459524272, "Internal haemorrhage": 4.192102329831255, "Intestinal haemorrhage": 2.676908134644101, "Iron deficiency anaemia": 2.6313255460329703, "Leukaemia": 9.608490019694605, "Leukaemia recurrent": 11.617710539545142, "Lower gastrointestinal haemorrhage": 3.1101176952098406, "Lung disorder": 2.0759857588599435, "Lung infiltration": 4.6469046727646095, "Lymphocytosis": 10.320595242868482, "Malignant neoplasm progression": 11.372091628735523, "Nephrotic syndrome": 4.127880030466489, "Neuropathy peripheral": 2.752704715333511, "Oedema": 2.82796459500404, "Pancytopenia": 5.439390932370854, "Pericardial effusion": 37.583723789601954, "Peripheral arterial occlusive disease": 5.745206768347362, "Philadelphia chromosome positive": 192.4662638449781, "Platelet count decreased": 2.826488156533723, "Platelet count increased": 3.0766663670874514, "Platelet transfusion": 16.0038120670919, "Pleural effusion": 109.1673010576023, "Pleurisy": 14.550612891694469, "Pneumonia": 3.620762731437638, "Pneumonia fungal": 4.46817887476219, "Prescribed underdose": 52.93167860462712, "Pulmonary alveolar haemorrhage": 2.1635207220795505, "Pulmonary arterial hypertension": 29.83150528206673, "Pulmonary congestion": 2.073864447408475, "Pulmonary hypertension": 36.72715378548201, "Pulmonary oedema": 35.807546041200844, "Rectal cancer": 5.135921517206346, "Red blood cell count decreased": 3.0576929227133136, "Respiratory tract congestion": 3.682723173175603, "Retinal haemorrhage": 2.575983980954837, "Right ventricular failure": 3.661962088952216, "Splenomegaly": 4.41393720894199, "Stem cell transplant": 26.56070785679696, "Subdural haematoma": 3.094663916061771, "Therapeutic response decreased": 4.487283938373748, "Therapy non-responder": 4.270333716845658, "Thrombocytopenia": 3.489514739676048, "Transfusion": 8.58733568032972, "Transplant": 8.925170501458705, "Tumour lysis syndrome": 3.264092860971662, "White blood cell count abnormal": 3.2207737585495084, "White blood cell count increased": 3.6235320047540127}
+{"platelet count decreased": 7.98, "thrombocytopenia": 13.48}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1023.json

@@ -1 +1 @@
-{"Completed suicide": 53.30328829485575, "Drug interaction": 16.656255131491992}
+{"alanine aminotransferase increased": 7.37, "ascites": 5.24, "aspartate aminotransferase increased": 9.37, "asthenia": 2.28, "blood bilirubin increased": 4.24, "blood creatine phosphokinase increased": 109.67, "blood creatine phosphokinase mb increased": 286.86, "blood lactate dehydrogenase increased": 28.96, "blood lactic acid increased": 84.69, "blood uric acid increased": 30.41, "chest discomfort": 2.04, "dysstasia": 7.48, "exposure during pregcy": 2.58, "foetal exposure during pregcy": 3.54, "gait disturbance": 5.34, "hepatic cirrhosis": 33.5, "hepatitis": 3.27, "hepatitis b": 56.11, "hepatitis b dna increased": 143.68, "hepatitis b surface antigen positive": 288.76, "hypoaesthesia": 3.98, "jaundice": 4.45, "lactic acidosis": 19.38, "liver function test abnormal": 4.31, "maternal exposure during pregcy": 2.52, "metabolic acidosis": 7.37, "multiple organ dysfunction syndrome": 3.73, "muscle atrophy": 19.52, "muscular weakness": 12.17, "myalgia": 2.39, "myoglobin blood increased": 293.65, "myopathy": 76.09, "myositis": 24.41, "neuropathy peripheral": 7.12, "oedema peripheral": 3.82, "rhabdomyolysis": 16.58}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1024.json

@@ -1 +1 @@
-{"Abnormal behaviour": 3.405736030382148, "Abnormal dreams": 2.702998184368318, "Aggression": 4.866415552809968, "Agitation": 3.947008318390966, "Akinesia": 60.21426549310371, "Apathy": 2.131198435493688, "Aspiration": 4.96983879617291, "Behaviour disorder": 3.3670274828395783, "Choking": 5.741959648652567, "Chromaturia": 20.417729351749163, "Colitis microscopic": 29.750259077171357, "Confusional state": 4.2149965511639325, "Coordination abnormal": 2.886576406507133, "Dehydration": 2.2680766342227727, "Delirium": 4.6624987622591725, "Delusion": 7.979028547149376, "Dementia": 6.316883951515079, "Disease progression": 3.296813932488486, "Disorientation": 3.98730445254888, "Dopamine dysregulation syndrome": 223.59585536084668, "Dyskinesia": 30.289171692590585, "Dysphagia": 20.125659654680128, "Dysstasia": 5.67475735952977, "Dystonia": 10.376329680771184, "Eating disorder": 3.147996652888444, "Fall": 4.120353612394122, "Feeding disorder": 2.8815379729520307, "Femur fracture": 3.138210888517888, "Fracture": 5.769176202321302, "Freezing phenomenon": 69.77136538612962, "Gait disturbance": 3.877088983650253, "Gait inability": 3.887561247038376, "Gambling disorder": 38.28915995569985, "General physical health deterioration": 3.102061139066422, "Hallucination": 14.215252239620208, "Hallucination, auditory": 3.80876539209585, "Hallucination, visual": 20.04913758685486, "Hip fracture": 3.4761500931010025, "Hyperkinesia": 34.63431122896784, "Hypersexuality": 88.54307920972444, "Hypokinesia": 10.896466820444084, "Ileus": 6.712852956988915, "Impulse-control disorder": 33.91390444203331, "Incorrect dose administered": 2.822161459869556, "Libido increased": 20.785353313834342, "Motor dysfunction": 5.006339917569944, "Movement disorder": 5.751234979080472, "Muscle rigidity": 16.086162379776695, "Musculoskeletal stiffness": 3.3576030236252605, "Nervousness": 3.309137962557001, "Neuroleptic malignant syndrome": 3.49465684394376, "Nightmare": 2.5097010206155463, "On and off phenomenon": 227.7982496854132, "Oral mucosal discolouration": 96.12341708593657, "Orthostatic hypotension": 6.362135201932418, "Paralysis": 4.33061368972657, "Paranoia": 5.749322435225319, "Parkinson's disease": 196.40166614224387, "Parkinsonian crisis": 840.9120212576136, "Parkinsonism": 7.755478468608146, "Pneumonia aspiration": 8.312145081727648, "Product complaint": 20.89472713737045, "Product prescribing error": 4.978415313901908, "Product quality issue": 2.3635455221260697, "Product residue present": 10.629254931708047, "Product size issue": 27.248367343819105, "Product supply issue": 35.574906451178286, "Product use complaint": 12.432151262976552, "Psychomotor hyperactivity": 11.438706786685517, "Psychotic disorder": 4.340717643291604, "Rhabdomyolysis": 2.870390291627024, "Salivary hypersecretion": 5.169761978430663, "Serotonin syndrome": 2.6394945306584607, "Somnolence": 2.16104717746886, "Speech disorder": 4.318665600082211, "Stereotypy": 36.10581657759274, "Sudden onset of sleep": 37.57989661377093, "Therapeutic product effect decreased": 2.360618906236981, "Therapeutic response shortened": 38.01429181564257, "Therapy cessation": 11.894260365424236, "Tremor": 4.080156149610642, "Urinary tract infection": 2.007486362317123, "Weight decreased": 2.2238754835402563, "Wrong technique in product usage process": 16.15472535526383}
+{"asphyxia": 15.52, "asthma": 8.08, "atrial fibrillation": 3.15, "bronchospasm": 9.01, "bronchospasm paradoxical": 221.66, "cardiac failure": 2.02, "chest discomfort": 4.14, "chest pain": 2.04, "chronic obstructive pulmonary disease": 22.67, "cough": 5.66, "device malfunction": 8.72, "dry mouth": 7.64, "dysphonia": 4.82, "dyspnoea": 3.89, "dysuria": 6.65, "epistaxis": 2.59, "glaucoma": 7.9, "hyperglycaemia": 2.49, "incorrect dose administered": 3.18, "incorrect route of product administration": 27.11, "lip swelling": 2.71, "lung disorder": 3.77, "oropharyngeal pain": 2.1, "pneumonia": 2.66, "product use in unapproved indication": 3.08, "productive cough": 11.22, "swelling face": 2.16, "swollen tongue": 4.81, "throat irritation": 5.86, "urinary retention": 11.95, "vision blurred": 2.32, "wheezing": 7.61, "wrong technique in product usage process": 3.54}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1025.json

@@ -1 +1 @@
-{"Abdominal pain": 3.699398444925811, "Lactic acidosis": 59.73239803503783, "Lipoatrophy": 502.6771923047401, "Pancreatitis": 11.936607486507832}
+{"aggression": 4.28, "agitation": 7.41, "amnesia": 2.85, "anxiety": 3.82, "confusional state": 4.7, "contraindicated product administered": 28.04, "delirium": 2.53, "disorientation": 2.45, "dissociation": 46.81, "dizziness": 2.35, "drug interaction": 2.89, "drug withdrawal syndrome": 38.53, "dry mouth": 4.32, "dysarthria": 2.31, "dyskinesia": 4.36, "euphoric mood": 18.36, "feeling abnormal": 6.24, "feeling drunk": 20.26, "hallucination": 9.66, "hallucination, auditory": 16.79, "hallucination, visual": 18.64, "hyperhidrosis": 4.89, "insomnia": 6.84, "irritability": 2.16, "muscle spasms": 5.48, "nausea": 2.32, "nightmare": 3.43, "priapism": 33.25, "product dispensing error": 10.33, "psychotic disorder": 4.89, "restlessness": 5.25, "sleep disorder": 4.4, "somnolence": 2.51, "suicidal ideation": 4.69, "tremor": 4.9, "vertigo": 7.05, "vomiting": 2.11, "withdrawal syndrome": 28.89, "wrong technique in product usage process": 3.88}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1027.json

@@ -1 +1 @@
-{"Acute kidney injury": 2.2231581024559484, "Haemorrhoids": 13.823249904224234, "Oedema": 5.473815044901856, "Sprue-like enteropathy": 16.07254395745642}
+{"blood glucose increased": 10.53, "device defective": 329.15, "device issue": 203.05, "device mechanical issue": 3155.85, "lipodystrophy acquired": 718.04}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1028.json

@@ -1 +1 @@
-{"Decreased appetite": 15.524314913312612, "Hyperammonaemia": 498.2714011121074}
+{"dyspareunia": 809.82, "endometrial thickening": 700.88, "hot flush": 60.83, "muscle spasms": 6.22, "vaginal haemorrhage": 33.94, "vulvovaginal discomfort": 303.28, "vulvovaginal dryness": 379.01, "vulvovaginal pain": 247.21, "vulvovaginal pruritus": 251.27}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1030.json

@@ -1 +1 @@
-{"Abortion induced": 55.492594492243846, "Alanine aminotransferase increased": 3.564923615819831, "Blood alkaline phosphatase increased": 10.51552654387456, "Drug interaction": 3.5488844248817992, "Gamma-glutamyltransferase increased": 13.98440149259873, "Gynaecomastia": 32.00288477148004, "Hepatic function abnormal": 6.044500916883304, "Immune reconstitution inflammatory syndrome": 50.74421148408263, "Insomnia": 2.223301781918884, "Liver injury": 11.968814558743084, "Overdose": 2.905313149425483, "Platelet count decreased": 2.614785858600858, "Pregnancy": 36.640987519026496, "Pruritus": 2.45016771698168, "Rash": 6.467424469518315, "Suicide attempt": 5.525759789595508, "Toxic skin eruption": 23.007443378207885, "Transaminases increased": 8.51162050351136}
+{"drug interaction": 13.3}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1031.json

@@ -1 +1 @@
-{"Acute kidney injury": 3.837093010245585, "Adrenal suppression": 6.897087185349649, "Anhedonia": 37.93305612535252, "Ankle fracture": 16.419407186686197, "Anxiety": 9.74465712378995, "Blood HIV RNA increased": 8.017341240353831, "Blood creatine increased": 3.9269584221099176, "Blood creatinine abnormal": 7.6005497975066785, "Blood creatinine increased": 6.959423137482869, "Blood phosphorus decreased": 3.7996629517840974, "Bone cyst": 12.0161605234461, "Bone demineralisation": 39.78471389191874, "Bone density abnormal": 44.9800487963953, "Bone density decreased": 41.367314904971614, "Bone disorder": 9.567419231356164, "Bone loss": 44.070120219291205, "CD4 lymphocytes decreased": 7.833713108836502, "Cervical vertebral fracture": 4.16721827273374, "Chronic kidney disease": 29.96502828292687, "Chronic kidney disease-mineral and bone disorder": 14.579060174187846, "Clavicle fracture": 11.025723719402247, "Compression fracture": 5.807050585340042, "Craniofacial fracture": 5.086296515270692, "Decreased activity": 8.72562595648275, "Degenerative bone disease": 38.18806742020685, "Dental caries": 4.099300429734812, "Depression": 2.185897463030438, "Drug resistance": 2.2244384333546305, "Dysstasia": 4.082773270989218, "Economic problem": 47.41659546093008, "Emotional distress": 31.391290817044823, "End stage renal disease": 13.156522103308722, "Fanconi syndrome": 6.001312126304554, "Fanconi syndrome acquired": 17.07001337853639, "Fear-related avoidance of activities": 44.68238171689551, "Femur fracture": 4.241734620439612, "Fibula fracture": 11.484953535141832, "Foot fracture": 13.093899613779907, "Fracture": 24.913703256263304, "Fractured coccyx": 7.70458096946798, "Gene mutation identification test positive": 16.558650560064695, "Genotype drug resistance test positive": 10.881243385437315, "Glomerular filtration rate abnormal": 19.99977407824438, "Glomerular filtration rate decreased": 7.059146965188791, "Glomerular filtration rate increased": 11.120092820898366, "HIV test positive": 8.126243426562583, "Hand fracture": 22.87269317018801, "Hepatitis B": 2.094615756278807, "Hip arthroplasty": 6.665369088413817, "Hip fracture": 5.156764603971011, "Hip surgery": 3.8955786074570313, "Humerus fracture": 3.2049474000090923, "Immune reconstitution inflammatory syndrome": 3.661143387132785, "Impaired work ability": 2.0435730049528598, "Intervertebral disc degeneration": 6.914664223853307, "Jaw fracture": 9.851149821781922, "Loss of personal independence in daily activities": 2.9151883326726065, "Lower limb fracture": 6.724854728671521, "Meniscus injury": 2.8838998318480638, "Multiple fractures": 39.76729575086082, "Nephrolithiasis": 3.558028936981078, "Nephropathy": 14.935658524312323, "Nephropathy toxic": 16.302223077865932, "Osteoarthritis": 4.125715809934811, "Osteochondrosis": 9.733075617096606, "Osteomalacia": 15.30060678883252, "Osteonecrosis": 40.16079280889993, "Osteopenia": 31.278487027827527, "Osteoporosis": 31.576430709141217, "Osteoporotic fracture": 4.512159499609686, "Pain": 4.357722095545041, "Patella fracture": 4.065729447325782, "Pathological fracture": 5.419408444349534, "Pelvic fracture": 2.0078561174450296, "Post-traumatic stress disorder": 4.149638767731106, "Protein total abnormal": 38.08103452661691, "Protein total increased": 16.158653148413833, "Protein urine present": 12.203197917789748, "Proteinuria": 4.7347056716076406, "Quality of life decreased": 8.731561370371342, "Radius fracture": 5.277221955770337, "Renal cyst": 2.4887361267350983, "Renal failure": 16.00421654754964, "Renal impairment": 5.999427301353714, "Renal injury": 25.85561510833812, "Renal tubular disorder": 5.482068065821315, "Renal tubular dysfunction": 5.2914957233283, "Renal tubular necrosis": 2.957742685840929, "Rib fracture": 12.038808566425972, "Shoulder fracture": 7.770960339319937, "Skeletal injury": 24.51679949132032, "Spinal compression fracture": 8.189066809692145, "Spinal disorder": 3.0617460029340062, "Spinal fracture": 9.637133745949392, "Spinal osteoarthritis": 8.63799507832165, "Spinal stenosis": 3.0833051558831768, "Spondylolisthesis": 11.455756623183191, "Stress fracture": 8.399935519389151, "Teeth brittle": 23.07609301873647, "Thoracic vertebral fracture": 3.348862490082252, "Tibia fracture": 10.712464721935309, "Toe amputation": 2.4233715198134385, "Tooth disorder": 3.680807680656984, "Tooth extraction": 5.042597811637255, "Tooth fracture": 21.65263019670649, "Tooth loss": 36.9627791881238, "Ulna fracture": 12.727599742554318, "Upper limb fracture": 6.600377437949353, "Vertebral foraminal stenosis": 22.88510668025476, "Viral load increased": 9.588219359523416, "Viral mutation identified": 7.4161622485859, "Virologic failure": 8.415654762306158, "Vitamin D decreased": 5.153770237075881, "Vitamin D deficiency": 14.623116481880254, "Walking aid user": 4.229195771901956, "Wrist fracture": 12.41062327368115}
+{"acute disseminated encephalomyelitis": 2.79, "adverse reaction": 3.17, "allodynia": 5.09, "areflexia": 2.66, "bedridden": 7.91, "bell's palsy": 5.62, "blister": 11.74, "burning sensation": 3.2, "cellulitis": 4.52, "coronavirus infection": 3.46, "deafness unilateral": 2.32, "demyelinating polyneuropathy": 5.81, "demyelination": 2.54, "diplegia": 2.09, "discomfort": 2.56, "disease prodromal stage": 210.95, "dysaesthesia": 2.55, "encephalitis": 3.14, "erysipelas": 2.06, "erythema": 3.58, "extensive swelling of vaccinated limb": 2.45, "extra dose administered": 4.23, "facial pain": 4.35, "facial paralysis": 2.59, "facial paresis": 2.32, "genital herpes": 3.87, "genital herpes zoster": 23.41, "genital rash": 5.36, "giant cell arteritis": 2.84, "groin pain": 2.33, "guillain-barre syndrome": 11.55, "herpes ophthalmic": 15.94, "herpes simplex": 9.29, "herpes virus infection": 7.64, "herpes zoster": 37.46, "herpes zoster cutaneous disseminated": 34.63, "herpes zoster disseminated": 9.56, "herpes zoster oticus": 28.53, "herpes zoster reactivation": 24.37, "hyperaesthesia": 9.27, "immobile": 4.96, "inappropriate schedule of product administration": 2.36, "incomplete course of vaccination": 78.43, "incorrect route of product administration": 4.23, "induration": 5.55, "influenza like illness": 2.17, "injected limb mobility decreased": 8.02, "injection site cellulitis": 5.38, "injection site discolouration": 4.21, "injection site discomfort": 2.31, "injection site erythema": 4.64, "injection site induration": 2.08, "injection site pain": 2.13, "injection site paraesthesia": 2.72, "injection site rash": 4.91, "injection site swelling": 3.09, "injection site vesicles": 13.24, "injection site warmth": 2.06, "lip blister": 6.69, "local reaction": 14.36, "loss of personal independence in daily activities": 3.6, "lyme disease": 2.64, "lymphangitis": 4.45, "mobility decreased": 4.24, "monoplegia": 3.03, "myelitis transverse": 3.29, "near death experience": 2.35, "nerve injury": 3.88, "neuralgia": 9.5, "neuralgic amyotrophy": 4.99, "neuritis": 4.99, "ophthalmic herpes simplex": 20.24, "ophthalmic herpes zoster": 36.11, "oral herpes": 9.33, "oral mucosal blistering": 3.41, "pain": 3.29, "pain in extremity": 2.77, "pain of skin": 6.95, "paralysis": 2.56, "peripheral swelling": 2.38, "peripheral vascular disorder": 3.42, "polymyalgia rheumatica": 4.79, "post herpetic neuralgia": 40.91, "product administered at inappropriate site": 4.54, "product administered to patient of inappropriate age": 16.71, "product supply issue": 7.51, "pruritus": 2.22, "pustule": 5.77, "radiculopathy": 3.19, "rash": 2.79, "rash erythematous": 2.01, "rash papular": 2.55, "rash pruritic": 2.47, "rash pustular": 5.2, "rash vesicular": 33.94, "scab": 5.24, "scar": 4.44, "skin lesion": 4.21, "skin warm": 6.61, "social problem": 2.71, "swelling": 2.75, "tenderness": 2.2, "trigeminal neuralgia": 4.17, "vaccination failure": 6.68, "vaccination site erythema": 2.7, "vaccination site induration": 2.04, "vaccination site inflammation": 4.8, "vaccination site joint swelling": 3.17, "vaccination site rash": 2.09, "vaccination site reaction": 2.09, "vaccination site swelling": 2.2, "vaccination site warmth": 3.16, "varicella zoster virus infection": 11.26, "walking aid user": 2.47}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1033.json

@@ -1 +1 @@
-{"Amnesia": 58.49653583304914, "Anxiety": 2.5182975219052115, "Chemical submission": 19458.108500057097, "Drug abuse": 86.9809708477372, "Drug dependence": 7.616059680106968, "Injection": 13466.474301417627, "Loss of consciousness": 4.456619762196874, "Somnolence": 3.336453482080453, "Substance abuse": 39.7798324017028, "Vomiting": 2.04686078547525}
+{"blood glucose increased": 8.11, "diabetes mellitus": 35.47, "diarrhoea": 2.79, "electrocardiogram qt prolonged": 9.68, "glycosylated haemoglobin increased": 33.94, "hyperglycaemia": 59.28, "product use in unapproved indication": 3.17, "weight decreased": 3.2}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1034.json

@@ -1 +1 @@
-{"Acute generalised exanthematous pustulosis": 7.403251602720803, "Acute pulmonary oedema": 8.897214010958006, "Acute respiratory distress syndrome": 4.355654829220852, "Allergy test negative": 186.1501833360041, "Anaesthetic complication": 65.0873203784674, "Anaesthetic complication neurological": 893.9317810214162, "Anaphylactic reaction": 16.491298678692914, "Anaphylactic shock": 109.9967214958737, "Anaphylactoid reaction": 19.71177305225272, "Anaphylactoid shock": 212.05232038263395, "Apnoea": 3.863862385315131, "Atrioventricular block": 7.754753396190877, "Blood pressure decreased": 4.480719009294605, "Bradycardia": 6.111009571809047, "Bradypnoea": 12.13644301079264, "Bronchospasm": 67.14935774584228, "Bronchospasm paradoxical": 74.50156901244907, "Cardiac arrest": 12.445443274570842, "Cardio-respiratory arrest": 11.00704668139615, "Cardiogenic shock": 7.741719728053575, "Cholestasis": 6.9087089196938845, "Circulatory collapse": 15.04516960572782, "Coma": 2.6877120496775144, "Conjunctivitis": 4.023517925245391, "Cyanosis": 3.113441726415781, "Eosinophilia": 6.226639698414206, "Erythema": 7.066878871803732, "Exposure during pregnancy": 3.6708429368905486, "Gastritis": 3.1270129199642613, "Haemodynamic instability": 18.45473884285001, "Hemiplegia": 4.1239994903891946, "Hepatic cytolysis": 7.54066673128345, "Histamine level increased": 233.4923689841373, "Horner's syndrome": 157.79323117684072, "Hypersensitivity": 2.066344387904365, "Hyperthermia malignant": 133.87630810898844, "Hypotension": 15.765911032941878, "Hypotonia": 3.0338722906143767, "Hypoxia": 4.237604610999548, "Inadequate analgesia": 40.11323721734267, "Incorrect route of product administration": 2.829203323601296, "Laryngospasm": 9.679819183490704, "Macule": 19.15446590647125, "Maternal exposure during delivery": 66.73311128693486, "Maternal exposure during pregnancy": 3.148377370358524, "Miosis": 9.856369291838975, "Myoclonus": 5.079150875332176, "Neuromuscular blockade": 151.23454294364646, "Normal newborn": 9.741556511994713, "Oxygen saturation decreased": 4.890130986763746, "Paraparesis": 15.96645380539012, "Pneumonia aspiration": 5.033002883227971, "Pneumothorax": 3.622375758224646, "Postoperative delirium": 809.6657414852194, "Premature baby": 2.173504966771082, "Procedural hypotension": 104.79014404852744, "Radiculopathy": 5.971469817310013, "Rash": 2.5161434758775045, "Rash maculo-papular": 4.735983068484234, "Rash morbilliform": 4.77817246800226, "Respiratory arrest": 3.5092173992090943, "Respiratory depression": 21.54729923188729, "Sedation": 4.0074381768675975, "Sedation complication": 10.832595028660094, "Shock": 22.7803855869522, "Shock haemorrhagic": 4.612095962920212, "Stress cardiomyopathy": 34.463940685367675, "Tachycardia": 6.671906180203018, "Toxic epidermal necrolysis": 2.765564380201957, "Toxic skin eruption": 5.716324515093811, "Type I hypersensitivity": 50.08235675337304, "Urinary incontinence": 2.5027041985782965, "Urticaria": 4.307469041577118, "Ventricular extrasystoles": 4.634709394888435, "Ventricular tachycardia": 2.9120515816660024, "Withdrawal syndrome": 2.6950279545415987}
+{"accidental overdose": 42.45, "anaemia": 10.7, "neutropenia": 22.59, "pancytopenia": 61.83, "thrombocytopenia": 22.21}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1035.json

@@ -1 +1 @@
-{"Anaphylactic reaction": 45.18902925887953, "Anaphylactic shock": 25.2329362032695, "Atrial fibrillation": 8.112249070660205, "Bradycardia": 22.046847964900927, "Bronchospasm": 39.75421879118719, "Cardiac arrest": 16.758361704744704, "Drug interaction": 9.928121370377337, "Hypotension": 6.915904718605427, "Neuromuscular block prolonged": 783.3574580078387, "Neuromuscular blockade": 1233.7163544188072, "Off label use": 2.786559025276401, "Recurrence of neuromuscular blockade": 1591.5272849619423, "Respiratory failure": 24.706460043659813, "Tachycardia": 4.160728933769897}
+{"acute myocardial infarction": 5.58, "ascites": 2.28, "blindness": 3.32, "blindness unilateral": 2.95, "blood potassium decreased": 2.66, "blood pressure decreased": 2.51, "cardiac arrest": 2.28, "cardiac failure": 2.69, "cardiogenic shock": 3.24, "cerebral haemorrhage": 2.32, "circulatory collapse": 2.59, "completed suicide": 2.42, "condition aggravated": 2.15, "drug ineffective for unapproved indication": 2.53, "drug interaction": 2.58, "dyschromatopsia": 31.74, "dyspepsia": 3.27, "dyspnoea exertional": 3.7, "erectile dysfunction": 6.79, "erection increased": 22.53, "eye haemorrhage": 3.5, "fluid retention": 6.32, "flushing": 4.93, "foetal exposure during pregcy": 2.1, "generalised tonic-clonic seizure": 2.58, "haemodynamic instability": 7.78, "haemoptysis": 3.22, "hypervolaemia": 9.16, "hypoacusis": 2.39, "hypotension": 3.71, "hypoxia": 4.94, "intentional product misuse": 2.68, "ischaemic stroke": 4.38, "maligt melanoma": 8.79, "maternal exposure during pregcy": 2.29, "nasal congestion": 5.8, "oedema": 3.23, "off label use": 2.08, "optic ischaemic neuropathy": 102.23, "oxygen saturation decreased": 5.09, "pain in jaw": 8.63, "penile pain": 22.79, "pericardial effusion": 2.73, "premature baby": 9.4, "premature delivery": 21.65, "prescription drug used without a prescription": 17.26, "priapism": 51.35, "product contamination": 72.58, "product counterfeit": 55.82, "product substitution issue": 3.83, "product use issue": 4.02, "pulmonary arterial hypertension": 28.28, "pulmonary arterial pressure increased": 43.74, "pulmonary hypertension": 21.13, "pulmonary oedema": 5.66, "respiratory arrest": 2.28, "respiratory failure": 2.15, "retinal vein occlusion": 7.29, "right ventricular failure": 30.3, "self-medication": 26.93, "subarachnoid haemorrhage": 5.53, "sudden death": 2.78, "therapeutic product effect incomplete": 2.04, "toxicity to various agents": 2.28, "transient global amnesia": 30.41, "ventricular tachycardia": 2.56, "vision blurred": 2.69, "visual acuity reduced": 3.25, "visual field defect": 6.59, "visual impairment": 2.2}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1036.json

@@ -1 +1 @@
-{"Acute hepatic failure": 16.54972415045368, "Clostridium difficile colitis": 13.851988879341262, "Decreased appetite": 2.062663679196262, "Diarrhoea": 2.794433340307961, "Disease progression": 13.34261564834975, "Drug interaction": 6.668701108923167, "Electrocardiogram QT prolonged": 16.8902170475667, "Epistaxis": 2.618178916718264, "Hair colour changes": 30.246649169899676, "Hypertension": 8.780199481446322, "Hypothyroidism": 18.01285600587825, "Leukopenia": 4.028418329041707, "Malignant neoplasm progression": 4.075736551178736, "Mucosal inflammation": 17.0382805141317, "Neoplasm progression": 6.036755141801905, "Nephrotic syndrome": 23.75094271928633, "Neutropenia": 4.956319524288265, "Osteonecrosis of jaw": 86.25154931662397, "Pain in jaw": 8.918078838186114, "Palmar-plantar erythrodysaesthesia syndrome": 21.856100254812542, "Periodontal disease": 259.7499988829635, "Posterior reversible encephalopathy syndrome": 22.447372708534235, "Proteinuria": 9.455354143398926, "Stomatitis": 4.320431895169893, "Thrombocytopenia": 5.871552950238839, "Thrombotic microangiopathy": 30.93138083052052}
+{"anogenital warts": 338.53, "cervical dysplasia": 223.59, "loss of consciousness": 3.05, "muscular weakness": 3.3, "papilloma viral infection": 303.78, "syncope": 5.3, "vertigo": 5.7}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1037.json

@@ -1 +1 @@
-{"Agitation": 3.851180370650725, "Depression": 4.237372718495712, "Drug interaction": 3.341036344521052, "Foetal exposure during pregnancy": 3.8997189349624337, "Gamma-glutamyltransferase increased": 14.588066774648752, "General physical health deterioration": 3.373776232891266, "Hallucination": 4.280479504365571, "Hepatic steatosis": 13.683564925922584, "Hepatitis": 8.30024654642637, "Lactic acidosis": 10.085088378464995, "Nightmare": 8.542291872123538, "Pancreatitis": 3.2123651582107637, "Pancreatitis acute": 12.270590573638067, "Rash maculo-papular": 7.275481477147968, "Suicidal ideation": 5.695086941939819}
+{"ejaculation disorder": 592.9, "ejaculation failure": 289.37, "loss of consciousness": 7.74, "orthostatic hypotension": 29.99, "prostate cancer": 6.64, "retrograde ejaculation": 956.1, "syncope": 5.62}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1039.json

@@ -1 +1 @@
-{"Adverse event": 6.207632202515212, "Agitation": 3.840086729726572, "Akathisia": 54.24927311229766, "Blood creatine phosphokinase increased": 4.372535158103086, "Bradykinesia": 44.57062450084656, "Delirium": 2.5435506695251493, "Disease recurrence": 4.334377342903216, "Disorientation": 6.522114262989159, "Drug-induced liver injury": 3.6339299462008894, "Dysarthria": 11.53932727711263, "Dysgeusia": 10.523392391982188, "Dyskinesia": 9.832642160628982, "Dysphagia": 3.72985930246459, "Dystonia": 11.28204736198916, "Electrocardiogram QT prolonged": 2.6684345088925614, "Extrapyramidal disorder": 65.71557977440469, "Generalised tonic-clonic seizure": 6.330328912397482, "Hospitalisation": 3.449759212018085, "Hypoaesthesia oral": 22.59341818626025, "Incorrect route of product administration": 23.306713323462887, "Increased appetite": 13.876496757354449, "Insomnia": 2.409123188764614, "Mania": 13.290526507603497, "Muscle rigidity": 13.567981271452318, "Muscle twitching": 3.480614704247663, "Nervousness": 2.9747076280888964, "Neuroleptic malignant syndrome": 59.92183755876987, "Off label use": 4.292096180564177, "Oral dysaesthesia": 163.14584172802412, "Paraesthesia oral": 5.346089278198875, "Parkinsonism": 42.65624719921861, "Pneumonia aspiration": 12.841027614980089, "Polydipsia": 25.35471915052848, "Prescribed overdose": 9.10113487826083, "Product taste abnormal": 23.7928495376452, "Psychomotor hyperactivity": 13.138707361169436, "Restless legs syndrome": 12.21988547548867, "Restlessness": 6.105658585660609, "Rhabdomyolysis": 7.34031382418971, "Salivary hypersecretion": 9.413352006965628, "Schizophrenia": 50.00330337169883, "Sedation": 38.9396529498552, "Sedation complication": 44.55508030635309, "Somnolence": 3.420558008435357, "Sopor": 12.741456486049302, "Suicidal ideation": 3.0313231557855578, "Suicide attempt": 5.416595422515599, "Tongue oedema": 10.430493009811324, "Tooth discolouration": 24.008684659261984, "Treatment noncompliance": 3.565968694159596, "Underdose": 4.4439306238259295, "Urinary incontinence": 9.408509834622276, "Urinary retention": 5.11871772005341, "Water intoxication": 158.27905800056652, "Weight increased": 2.8009153058188665}
+{"blepharitis": 53.78, "blindness": 3.45, "blindness unilateral": 8.9, "blood pressure decreased": 7.27, "cataract": 3.03, "conjunctival hyperaemia": 43.36, "conjunctivitis": 30.19, "conjunctivitis allergic": 70.4, "drug intolerance": 6.15, "dry eye": 17.0, "dry mouth": 16.8, "dry throat": 12.46, "dysgeusia": 2.8, "eczema": 2.67, "eczema eyelids": 367.98, "erythema of eyelid": 98.56, "eye allergy": 399.23, "eye discharge": 57.16, "eye disorder": 5.33, "eye inflammation": 13.66, "eye irritation": 76.27, "eye pain": 17.86, "eye pruritus": 53.78, "eye swelling": 6.53, "eyelid irritation": 89.48, "eyelid oedema": 9.02, "foreign body sensation in eyes": 95.46, "glaucoma": 15.69, "hypersensitivity": 2.47, "hypotension": 2.67, "intraocular pressure increased": 44.24, "keratitis": 56.39, "lacrimation increased": 25.05, "liquid product physical issue": 26.28, "nightmare": 3.18, "ocular discomfort": 14.61, "ocular hyperaemia": 114.3, "photophobia": 6.78, "product packaging quantity issue": 61.77, "product physical consistency issue": 53.21, "product quality issue": 11.12, "sleep disorder": 2.04, "somnolence": 2.75, "swelling of eyelid": 25.13, "uveitis": 35.03, "vision blurred": 8.44, "visual acuity reduced": 4.35, "visual impairment": 5.15, "wrong technique in product usage process": 3.52}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1040.json

@@ -1 +1 @@
-{"Disease progression": 17.14924489097697, "Infusion related reaction": 10.35582239423618, "Neutropenia": 3.97892145707637, "Off label use": 6.3657720319622015, "Pneumonia": 2.8100841058076487, "Thrombocytopenia": 4.540810287748204}
+{"blood bilirubin increased": 15.17, "drug ineffective": 8.0, "drug interaction": 7.72, "hepatitis c": 342.71, "hyperbilirubinaemia": 42.05, "off label use": 10.7, "photosensitivity reaction": 26.04, "product use issue": 19.18, "treatment failure": 29.2}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1043.json

@@ -1 +1 @@
-{"Bronchiolitis": 778.7056142568129, "Bronchitis": 12.842557096153971, "Cough": 3.714614937402436, "Crying": 9.757838990373523, "Cyanosis": 15.047732238951893, "Febrile convulsion": 104.20822628646177, "Gait disturbance": 2.308233809316597, "Gastroenteritis": 49.50427881908052, "Hypotonia": 15.49436104679001, "Hypotonic-hyporesponsive episode": 157.4062306832819, "Nasopharyngitis": 5.439013643771641, "Otitis media": 171.24733030314465, "Pharyngitis": 41.23229230924512, "Pharyngotonsillitis": 1141.1071288927312, "Pneumonia": 2.5341077722995995, "Pyrexia": 3.217042861448929, "Rhinorrhoea": 6.683469626978567, "Seizure": 2.5735260394938924, "Tonsillitis": 50.87302756135354, "Upper respiratory tract infection": 36.55224574583768}
+{"acute kidney injury": 3.85, "angioedema": 9.02, "drug interaction": 21.68, "off label use": 3.87, "product use in unapproved indication": 10.29}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1044.json

@@ -1 +1 @@
-{"Acute graft versus host disease": 9.556973829554424, "Acute kidney injury": 4.632972201997329, "Aplasia pure red cell": 9.435409341152765, "Aspergillus infection": 13.91952464524402, "Bacterial infection": 4.539085156493998, "Blood creatinine increased": 3.813735773258565, "Blood magnesium decreased": 14.473511721623495, "Bronchopulmonary aspergillosis": 15.253063593946726, "Candida infection": 13.267752348376414, "Complications of transplanted kidney": 74.50705244939448, "Contraindicated product administered": 2.7845585326378406, "Cytomegalovirus infection": 15.157237278663734, "Cytomegalovirus infection reactivation": 11.550805057576676, "Cytomegalovirus viraemia": 20.03520013050089, "Delirium": 3.1871101315817185, "Diffuse large B-cell lymphoma": 9.65208618744716, "Drug interaction": 15.81470973551902, "Drug level below therapeutic": 20.324218023469687, "Drug level decreased": 20.65286278363047, "Drug level increased": 28.988626951777054, "Drug-induced liver injury": 2.4391465791004365, "Electrocardiogram QT prolonged": 3.153313608304094, "Electrolyte imbalance": 11.05953188385152, "Encephalopathy": 3.0534522890184603, "Epstein-Barr virus infection": 14.84013748743892, "Foetal exposure during pregnancy": 2.2210328204057324, "Fungal infection": 6.372367484662919, "Gastric ulcer": 3.8335378448649, "Graft versus host disease": 26.73033623851588, "Graft versus host disease in gastrointestinal tract": 27.46189931928016, "Hepatotoxicity": 2.315869496282281, "Hiccups": 7.0034951531256535, "Hyperkalaemia": 9.201204064119976, "Immunosuppressant drug level decreased": 248.0418648889223, "Immunosuppressant drug level increased": 264.6432124536741, "Kidney transplant rejection": 43.66762927488129, "Labelled drug-drug interaction medication error": 8.395399340523921, "Leukopenia": 2.2101277584479933, "Liver transplant rejection": 108.23083641779152, "Mental status changes": 4.740266931794532, "Multiple organ dysfunction syndrome": 2.2936034813393302, "Nephropathy toxic": 26.15257354673421, "Neurotoxicity": 11.378608573956864, "Nocardiosis": 66.56801510090207, "Oesophageal candidiasis": 15.158382280624116, "Off label use": 2.2965601647263867, "Peritonitis": 9.178477286389231, "Polyomavirus-associated nephropathy": 70.68430142199296, "Post transplant lymphoproliferative disorder": 23.09285420269395, "Posterior reversible encephalopathy syndrome": 13.802264725416752, "Premature baby": 6.992214468985721, "Premature delivery": 3.789818494331719, "Renal impairment": 4.091469548624541, "Renal tubular necrosis": 6.980908071945522, "Respiratory failure": 2.0172091985146725, "Scedosporium infection": 118.72095024196096, "Septic shock": 2.38036609686691, "Skin lesion": 3.007428543531706, "Squamous cell carcinoma of skin": 21.68212317763691, "Staphylococcal infection": 3.4611760965196705, "Thrombotic microangiopathy": 24.854055910318632, "Toxicity to various agents": 4.897400962091449, "Transplant rejection": 48.36680142436104, "Tuberculosis": 7.325966222814844, "Varicella zoster virus infection": 22.159620992696937}
+{"anaemia": 3.16, "electrocardiogram qt prolonged": 167.77, "intentional product use issue": 13.62, "off label use": 5.09}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1045.json

@@ -1 +1 @@
-{"Basal cell carcinoma": 45.30284295792817, "Blood pressure increased": 2.6807247592811034, "Cardiac failure": 6.523497642483212, "Drug interaction": 2.4814046230106723, "Malignant melanoma": 27.122319976752102, "Respiratory syncytial virus infection": 47.11616481082915, "Toxicity to various agents": 3.4816910427180288}
+{"angioedema": 5.2, "completed suicide": 19.51, "diabetes mellitus inadequate control": 30.29, "drug interaction": 4.73, "hypoglycaemia": 14.88, "lactic acidosis": 30.01, "pemphigoid": 49.19, "toxicity to various agents": 6.66}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1046.json

@@ -1 +1 @@
-{"Acute kidney injury": 6.895030961377874, "Cardiac failure": 15.078673608076889, "Dyspnoea": 2.085228787503045, "Syncope": 8.648516371117791}
+{"anaemia": 6.82, "off label use": 5.36, "thrombocytopenia": 13.07}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1047.json

@@ -1 +1 @@
-{"Asthenia": 2.0297665972138086, "Cardiac failure": 2.1326734237511453, "Death": 6.644593702886772, "Disease progression": 2.428502090800721, "Dysphagia": 5.337199756249735, "General physical health deterioration": 2.256908028393501, "Hospitalisation": 3.607536407949742, "Hyperkeratosis": 31.339646439611634, "Hyperpyrexia": 16.748828454881412, "Malignant melanoma": 26.51803200313268, "Malignant neoplasm progression": 10.074603566996371, "Metastases to central nervous system": 35.97684734159338, "Metastases to lung": 10.738587887181808, "Metastatic malignant melanoma": 127.91629892137396, "Neutropenia": 2.0196736576082213, "Palmoplantar keratoderma": 337.1039155598279, "Product use in unapproved indication": 2.324539554268213, "Pyrexia": 3.2416631478560416, "Skin papilloma": 56.4605016308825, "Uveitis": 33.144610733618265}
+{"abdominal discomfort": 13.75, "abdominal pain": 4.21, "abdominal pain upper": 10.16, "alanine aminotransferase increased": 3.13, "aspartate aminotransferase increased": 2.36, "burning sensation": 4.01, "diarrhoea": 6.65, "drug intolerance": 5.01, "eosinophil count increased": 30.08, "eosinophilia": 35.96, "erythema": 3.87, "feeling hot": 2.62, "flatulence": 4.94, "flushing": 56.67, "gastrointestinal disorder": 16.7, "gastrointestinal pain": 24.15, "hot flush": 11.34, "leukopenia": 6.09, "lymphocyte count decreased": 109.03, "lymphopenia": 278.26, "proteinuria": 9.45, "pruritus": 2.69, "psoriasis": 29.48, "skin burning sensation": 12.56, "therapeutic response unexpected": 17.95}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1048.json

@@ -1 +1 @@
-{"Acne": 3.9817893001292526, "Acquired gene mutation": 14.86060427971434, "Aplastic anaemia": 2.4584023089024867, "Atelectasis": 2.37771660757051, "Blood creatine phosphokinase increased": 2.6123542299220905, "Blood sodium decreased": 2.0135075514031517, "Body height decreased": 4.185769001700461, "Brain neoplasm": 6.644883522038496, "Brain oedema": 3.1302435548088, "Carcinoembryonic antigen increased": 42.61673227311675, "Cardiac dysfunction": 12.327542922884517, "Cardiac failure": 8.52071036093018, "Cardiac failure acute": 5.251452961857661, "Cardiac failure chronic": 3.822153430360925, "Cardiac failure congestive": 2.507312373537516, "Cardiac tamponade": 5.463955370606241, "Cardiomyopathy": 5.997049806132496, "Cardiotoxicity": 4.967330641045299, "Cerebral infarction": 3.4034875300558856, "Conjunctivitis": 2.064826211216725, "Cutaneous vasculitis": 3.395635663936643, "Decreased appetite": 3.3204262462477563, "Deep vein thrombosis": 2.185114127131098, "Dermatitis": 3.8455674481922655, "Dermatitis acneiform": 23.26756462073814, "Diarrhoea": 3.4767849022646558, "Dilated cardiomyopathy": 3.147025142157053, "Disease progression": 2.480300105556443, "Drug eruption": 2.929434774742854, "Drug resistance": 4.47367629226466, "Dry eye": 2.448772686386256, "Dry skin": 9.05282648504712, "EGFR gene mutation": 44.62231329418593, "Ejection fraction decreased": 11.295137675058209, "Electrocardiogram QT prolonged": 14.629520935685772, "Erythema multiforme": 5.641609336630526, "Feeding disorder": 3.094787333093971, "Femur fracture": 2.416476449857122, "Fracture": 2.645747600499752, "Haematotoxicity": 2.965636279316429, "Haemoptysis": 2.417693027600344, "Heart failure with reduced ejection fraction": 28.31332695155776, "Hepatic function abnormal": 2.429688221568133, "Hypophagia": 2.2703870435921254, "Interstitial lung disease": 47.55755804580372, "Keratitis": 19.58168248049645, "Liver disorder": 3.2453349166959704, "Long QT syndrome": 15.736520794768186, "Lung disorder": 8.477348622658056, "Lung infiltration": 2.1073581419576777, "Lung neoplasm malignant": 8.157281600255411, "Lung opacity": 22.832835082362784, "Lymphangiosis carcinomatosa": 54.89363797859607, "Malignant neoplasm progression": 23.07686060217942, "Malignant pleural effusion": 16.791500949232315, "Metastases to bone": 16.023886140613364, "Metastases to central nervous system": 50.12358179331599, "Metastases to liver": 7.575937267365127, "Metastases to lung": 6.587186732999116, "Metastases to lymph nodes": 7.505266377899103, "Metastases to meninges": 80.14189619352831, "Metastases to pleura": 27.48685934398338, "Metastases to spine": 15.279311033087652, "Metastasis": 19.640796287052037, "Mouth ulceration": 2.0692533413201595, "Mucosal disorder": 6.642481227070001, "Mucosal inflammation": 3.283513389119108, "Myelosuppression": 2.6984300502336844, "Nail bed inflammation": 116.04007033133642, "Nail disorder": 27.50616212964865, "Neoplasm progression": 2.3573911721813654, "Neutrophil count decreased": 2.1104475114733785, "No adverse event": 2.7729909872459397, "Non-small cell lung cancer": 11.60562978054623, "Onychoclasis": 37.42974064973691, "Paronychia": 140.35659557675618, "Pericardial effusion": 3.709610246804262, "Platelet count decreased": 4.392614564417044, "Pleural effusion": 10.053933699554422, "Pneumocystis jirovecii pneumonia": 2.552700740824178, "Pneumonia aspiration": 2.26254680295525, "Pneumonia bacterial": 8.470957817758496, "Pneumonitis": 41.91260667605256, "Pneumothorax": 6.265809169077893, "Pulmonary alveolar haemorrhage": 4.041715289510191, "Pulmonary embolism": 3.061761150380486, "Pulmonary mass": 2.911086503171793, "Pulmonary oedema": 2.7454816572585274, "Pulmonary toxicity": 63.23391072785357, "Pustule": 2.946345586943139, "Rash": 2.3210180146443222, "Recurrent cancer": 10.40935008333442, "Respiratory failure": 2.934155550665392, "SARS-CoV-2 test negative": 12.007149456124772, "Skin disorder": 5.413889254239975, "Skin fissures": 16.32960554174431, "Skin toxicity": 7.815781450501984, "Skin ulcer": 2.032602812468616, "Small cell lung cancer": 21.49811021775693, "Stomatitis": 5.472740746696174, "Taste disorder": 3.310603632309159, "Thrombocytopenia": 3.954335554020756, "Torsade de pointes": 2.3862463935662435, "Tumour marker increased": 11.272312365499168}
+{"abortion spontaneous": 2.83, "acne": 2.91, "arthritis": 2.87, "arthropathy": 3.47, "breast cancer female": 3.88, "c-reactive protein increased": 3.1, "crohn's disease": 5.97, "dermatitis exfoliative generalised": 8.61, "device issue": 13.99, "eczema": 4.97, "fungal infection": 5.04, "hepatic cirrhosis": 6.75, "hospitalisation": 2.05, "infection": 2.58, "injection site haemorrhage": 7.31, "intestinal obstruction": 4.76, "lymphoma": 7.89, "maternal exposure during pregcy": 3.52, "psoriasis": 58.36, "psoriatic arthropathy": 14.94, "skin disorder": 3.07, "skin exfoliation": 3.86, "skin lesion": 3.81, "skin plaque": 23.29, "stress": 3.34, "surgery": 4.09, "therapeutic product effect decreased": 4.36, "therapeutic product effect incomplete": 4.51, "therapeutic response shortened": 56.02, "tuberculosis": 9.29, "unevaluable event": 13.77, "urinary tract infection": 2.06}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1049.json

@@ -1 +1 @@
-{"Injection site pain": 2.943954252386543}
+{"aggression": 81.16, "agitation": 35.1, "irritability": 28.02, "middle insomnia": 121.03, "product administered to patient of inappropriate age": 103.26, "somnolence": 3.31}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/105.json

@@ -1 +1 @@
-{"Abdominal discomfort": 11.366995864393528, "Alopecia": 11.53889758522827, "Anti-cyclic citrullinated peptide antibody": 18.884061263319705, "Anti-cyclic citrullinated peptide antibody positive": 55.833767501792, "Arthropathy": 21.884931133281384, "Atelectasis": 27.950465274634503, "Autoimmune disorder": 8.58288867959757, "Barrett's oesophagus": 72.22825313802474, "Blister": 20.85342885254644, "Blood cholesterol increased": 3.198187677916212, "Bursitis": 6.845969820040452, "C-reactive protein abnormal": 8.214585091180096, "Computerised tomogram thorax": 490.7821148960112, "Computerised tomogram thorax abnormal": 127.24802931445866, "Condition aggravated": 6.533140997070747, "Confusional state": 8.304303866771997, "Contraindicated product administered": 19.48181001863859, "Contusion": 17.2122099043093, "Deep vein thrombosis postoperative": 27.82150165726569, "Discomfort": 22.677592482980696, "Drug hypersensitivity": 2.810212022339558, "Drug intolerance": 7.682090277745229, "Duodenal ulcer perforation": 90.4668098392763, "Dyspepsia": 2.4009209694429616, "Dyspnoea": 2.6451684101365225, "Erosive oesophagitis": 194.66640392393444, "Eructation": 14.993387411042413, "Facet joint syndrome": 9.568040256098945, "Folliculitis": 67.6329721027273, "Gastrointestinal disorder": 21.183754298772264, "General physical health deterioration": 12.675750125958908, "Glossodynia": 31.26092587474628, "Haematemesis": 7.128287150578749, "Haematoma": 2.2415298008861395, "Hand deformity": 45.12003483895201, "Helicobacter infection": 82.99315107728042, "Hepatic enzyme increased": 16.99299136086368, "Hypersensitivity": 8.025801396188982, "Hypoxia": 3.6506345400712936, "Ill-defined disorder": 36.56523764826924, "Impaired healing": 50.58495734397461, "Infection": 12.10962647505432, "Infusion related reaction": 19.524010325729176, "Injury": 17.917157806599448, "Irritable bowel syndrome": 12.84806847105128, "Lower respiratory tract infection": 3.8057202539450303, "Muscle injury": 10.68946862316932, "Oesophageal haemorrhage": 221.55515272500247, "Oesophageal mucosal dissection": 3985.207007354716, "Oropharyngeal discomfort": 10.805707007532696, "Regurgitation": 58.52446894248711, "Respiratory syncytial virus infection": 11.862777383961882, "Vitamin B12 deficiency": 48.45176838222381}
+{"depression": 2.26, "fall": 2.79, "gait disturbance": 4.59, "influenza like illness": 2.57, "memory impairment": 2.73, "multiple sclerosis": 38.78, "multiple sclerosis relapse": 45.75, "muscle spasticity": 36.87, "urinary tract infection": 3.22}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1051.json

@@ -1 +1 @@
-{"Acute kidney injury": 4.482919413466625, "Dermatitis acneiform": 109.56520027175364, "Diarrhoea": 3.910945204404408, "Drug interaction": 8.112214270459697, "International normalised ratio increased": 8.283980724673425, "Interstitial lung disease": 9.02994101022334, "Rash": 3.125658466136694}
+{"anaemia": 2.97, "bradycardia": 9.72, "drug ineffective": 7.68, "drug interaction": 5.21, "hepatitis c": 199.66, "hepatocellular carcinoma": 79.08, "treatment failure": 106.12}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1054.json

@@ -1 +1 @@
-{"Acute myeloid leukaemia": 24.392855630902638, "Agranulocytosis": 32.64999280948443, "Alopecia": 15.24131808896068, "Breast cancer": 2.3841679570405825, "Cardiac failure": 3.7044940923482015, "Diarrhoea": 2.6104567287426024, "Febrile bone marrow aplasia": 47.19696517020128, "Febrile neutropenia": 10.331509711212863, "Flushing": 3.3897819379479044, "Granulocytopenia": 10.186004229820725, "Hepatic function abnormal": 2.8702610770476173, "Interstitial lung disease": 8.553226188585219, "Leukopenia": 15.415440388408028, "Lung disorder": 2.001515387755858, "Malignant neoplasm progression": 2.4246877508444062, "Mucosal inflammation": 10.3136214171609, "Myelosuppression": 17.546431551703954, "Neuropathy peripheral": 2.272561801768008, "Neutropenia": 8.595250315089919, "Neutrophil count decreased": 13.76337197432074, "Oedema": 3.1204572923275715, "Palmar-plantar erythrodysaesthesia syndrome": 4.153081478533539, "Pancytopenia": 3.252733923666057, "Pleural effusion": 2.6175662514993405, "Pneumonitis": 3.392565185806798, "Prostatic specific antigen increased": 8.12737713949123, "Psychological trauma": 231.20972511778865, "Sepsis": 2.791674046342254, "Septic shock": 4.0061911267247465, "Skin exfoliation": 4.51448753622689, "Stomatitis": 9.298416330429918, "White blood cell count decreased": 15.763995605032802}
+{"injection site pain": 11.67, "nausea": 3.46}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1055.json

@@ -1 +1 @@
-{"Balance disorder": 5.827939587163809, "Fall": 3.620177402181327, "Flushing": 13.435949972517502, "Gait disturbance": 3.11789893368362, "Gastrointestinal disorder": 2.970599946549323, "Memory impairment": 6.514345875131827, "Multiple sclerosis": 46.771396749336944, "Multiple sclerosis relapse": 48.757346912509696, "Muscle spasms": 3.784136065385861, "Muscle spasticity": 27.69113142670508, "Muscular weakness": 2.5932401840977333, "Urinary tract disorder": 83.19803877622537}
+{"apnoea": 13.4, "aspartate aminotransferase increased": 2.31, "blood alkaline phosphatase increased": 3.99, "brain neoplasm": 35.71, "condition aggravated": 2.83, "contusion": 2.58, "craniopharyngioma": 589.33, "diabetes mellitus": 7.61, "disease recurrence": 11.16, "drug abuse": 2.79, "eating disorder": 6.36, "epiphysiolysis": 778.18, "fluid retention": 3.76, "focal nodular hyperplasia": 163.38, "gastrointestinal infection": 28.39, "glucose tolerance impaired": 90.41, "glycosylated haemoglobin increased": 5.24, "head injury": 5.09, "hypoglycaemia": 3.31, "hypothyroidism": 2.01, "idiopathic intracranial hypertension": 250.89, "increased appetite": 12.82, "injection site atrophy": 95.03, "injection site bruising": 12.17, "injection site haemorrhage": 11.88, "insulin-like growth factor increased": 268.58, "intracranial pressure increased": 53.46, "lower limb fracture": 14.49, "meningioma": 37.33, "neoplasm recurrence": 102.1, "obstructive sleep apnoea syndrome": 138.43, "off label use": 3.64, "osteonecrosis": 2.54, "pancreatitis acute": 6.63, "papilloedema": 27.76, "pituitary tumour benign": 62.16, "product dose omission issue": 2.87, "product prescribing error": 12.07, "protein-losing gastroenteropathy": 221.79, "scoliosis": 116.6, "sleep apnoea syndrome": 58.68, "snoring": 102.17, "stress": 3.23, "sudden death": 21.85, "sulphaemoglobinaemia": 1448.89, "therapeutic response unexpected": 3.22, "tonsillar disorder": 216.49, "type 2 diabetes mellitus": 11.12, "viral infection": 4.93}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1056.json

@@ -1 +1 @@
-{"Drug resistance": 254.29199408251824, "Off label use": 23.71985354584165}
+{"abdominal distension": 2.53, "acromegaly": 353.0, "amnesia": 2.19, "arterial occlusive disease": 10.65, "arthritis": 2.72, "arthropathy": 3.51, "blood cholesterol abnormal": 26.38, "blood cholesterol increased": 4.55, "blood glucose abnormal": 3.29, "blood growth hormone increased": 777.64, "brain neoplasm": 23.52, "cholelithiasis": 9.8, "diabetes mellitus": 4.81, "gait disturbance": 2.15, "glycosylated haemoglobin increased": 6.52, "heart rate decreased": 3.91, "hepatic enzyme increased": 2.85, "hip fracture": 2.91, "incorrect route of product administration": 4.06, "injection site bruising": 36.18, "injection site haematoma": 5.97, "injection site haemorrhage": 10.62, "injection site induration": 3.66, "injection site mass": 8.67, "injection site oedema": 5.47, "injection site reaction": 2.04, "insulin-like growth factor abnormal": 1462.37, "insulin-like growth factor decreased": 516.62, "insulin-like growth factor increased": 966.53, "intentional dose omission": 8.5, "intentional product misuse": 4.59, "limb injury": 7.39, "lipodystrophy acquired": 39.93, "lipohypertrophy": 129.48, "needle issue": 26.15, "neoplasm": 37.79, "neoplasm progression": 7.09, "off label use": 4.5, "osteoarthritis": 2.92, "pituitary tumour": 244.26, "pituitary tumour benign": 112.46, "pituitary tumour recurrent": 337.98, "polyp": 21.94, "poor quality product administered": 23.25, "product complaint": 7.5, "product dose omission in error": 10.26, "product dose omission issue": 8.09, "product preparation issue": 9.07, "product storage error": 5.23, "product use issue": 12.84, "road traffic accident": 2.5, "syringe issue": 18.48, "tendonitis": 2.8, "therapeutic product effect incomplete": 4.47, "therapeutic response unexpected": 2.15, "vital functions abnormal": 98.47, "weight increased": 2.92, "wound infection": 21.53, "wrong technique in device usage process": 11.27, "wrong technique in product usage process": 2.82}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1057.json

@@ -1 +1 @@
-{"Abdominal discomfort": 5.104824008091869, "Abdominal distension": 11.73864840142442, "Abdominal pain upper": 2.0946547610980635, "Anxiety": 2.421300950542125, "Apathy": 24.28397027051843, "Back pain": 3.809716613112885, "Balance disorder": 5.59142392900722, "Body temperature increased": 3.919760171494613, "Brain fog": 23.39382677643475, "Compression fracture": 119.30276811746002, "Contusion": 4.402898631708857, "Cough": 2.177310771427423, "Defaecation urgency": 132.1431431313278, "Depressed level of consciousness": 7.268014319753883, "Depression": 2.2393716335766176, "Eructation": 49.58185978617529, "Faeces hard": 249.298143700698, "Fall": 2.472132159958925, "Feeding disorder": 22.883103439136296, "Feeling abnormal": 5.343288421107279, "Flatulence": 24.34308121387681, "Frequent bowel movements": 42.62433073776352, "Gastrointestinal stoma complication": 827.8331164307498, "Gastrointestinal stoma output abnormal": 9535.860229578517, "Hiccups": 52.35140991832138, "Hot flush": 6.604050365706294, "Hypersomnia": 19.015954812781917, "Insomnia": 2.757819922179056, "Intestinal obstruction": 48.92497417169078, "Joint swelling": 4.873595929433718, "Lethargy": 5.576677379220881, "Lumbar vertebral fracture": 131.57213863050626}
+{"hallucination": 8.51, "intentional overdose": 63.23, "overdose": 11.21, "somnolence": 5.37, "suicide attempt": 13.92, "tachycardia": 4.3}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1058.json

@@ -1 +1 @@
-{"Abdominal pain": 2.595551872054118, "Fall": 4.650179772400432}
+{"dysgeusia": 38.62, "muscle spasms": 32.71}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1059.json

@@ -1 +1 @@
-{"Anaemia": 2.7779060769933666, "Cytopenia": 19.392637927828638, "Decreased appetite": 7.484064545801361, "Diarrhoea": 2.654596057841608, "Febrile neutropenia": 2.600021384872554, "Gastrointestinal disorder": 3.325434378516533, "Granulocyte count decreased": 35.40515316876338, "Haemoglobin decreased": 6.601374361586855, "Interstitial lung disease": 5.915587462163558, "Leukopenia": 9.690425588184556, "Malignant neoplasm progression": 2.341822028937473, "Myelosuppression": 98.16820857735608, "Neuropathy peripheral": 6.867848095559886, "Neutropenia": 8.98635464861954, "Neutrophil count decreased": 46.5933605454822, "Platelet count decreased": 24.203811143532118, "Red blood cell count decreased": 15.814446673867652, "Renal impairment": 2.069044047804484, "Thrombocytopenia": 5.370758502293885, "White blood cell count decreased": 32.39378602539339}
+{"anaphylactic reaction": 19.98, "anaphylactic shock": 42.45, "anaphylactoid reaction": 33.04, "blood pressure decreased": 16.93, "blood pressure immeasurable": 118.39, "bradycardia": 12.83, "bronchospasm": 7.31, "cardiac arrest": 9.62, "cardio-respiratory arrest": 10.26, "chest discomfort": 2.72, "circulatory collapse": 4.01, "cold sweat": 7.26, "contrast media reaction": 88.42, "cyanosis": 16.08, "depressed level of consciousness": 2.0, "dyspnoea": 3.14, "electrocardiogram st segment elevation": 21.58, "erythema": 6.4, "feeling hot": 7.09, "flushing": 14.24, "heart rate decreased": 8.52, "hyperhidrosis": 5.51, "hypersensitivity": 9.03, "hypotension": 14.15, "loss of consciousness": 5.53, "ocular hyperaemia": 3.99, "off label use": 2.15, "oxygen saturation decreased": 9.26, "pallor": 4.54, "paraesthesia": 2.0, "paraesthesia oral": 3.5, "presyncope": 6.63, "pulse absent": 24.98, "rash": 2.1, "respiratory arrest": 5.3, "respiratory distress": 4.94, "resuscitation": 46.11, "shock": 4.31, "tachycardia": 2.75, "throat irritation": 2.18, "throat tightness": 5.34, "unresponsive to stimuli": 4.15, "urticaria": 2.76, "ventricular fibrillation": 11.05}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/106.json

@@ -1 +1 @@
-{"Acute kidney injury": 14.52064540017142, "Acute respiratory distress syndrome": 2.472991548016431, "Ageusia": 2.181154585719559, "Agranulocytosis": 2.004319071571178, "Aneurysm": 11.412858478747223, "Angioedema": 6.318404623719389, "Anuria": 6.311208650492318, "Aplasia pure red cell": 3.8706485737598055, "Aspiration": 8.440067063008858, "Bacteraemia": 4.905155051381043, "Blood creatine phosphokinase increased": 4.43309110819312, "Blood creatinine increased": 4.450656836076559, "Blood potassium increased": 2.9806674156757595, "Blood pressure abnormal": 3.124653917256459, "Blood pressure fluctuation": 4.204710477006564, "Blood pressure inadequately controlled": 4.671685687153838, "Blood pressure increased": 4.769438576719344, "Blood urea increased": 2.3481193306490296, "Blood uric acid increased": 4.358617444526064, "Bradycardia": 4.701570931250727, "Bundle branch block left": 8.415018469696934, "Cardio-respiratory arrest": 3.5116075199547474, "Cardiogenic shock": 2.2873306719462456, "Cholestasis": 2.178512795890986, "Coma": 2.5074433303439903, "Cutaneous vasculitis": 11.179387334071526, "Dehydration": 3.039183739363568, "Dermatitis exfoliative generalised": 5.290564489023077, "Dyspepsia": 2.1767888702875564, "Eczema": 3.733806859456663, "Eosinophilia": 5.603570250181797, "Erectile dysfunction": 3.526972715731545, "Erysipelas": 6.778911350005282, "Face oedema": 2.664268242226385, "Fall": 2.918674806346199, "Gamma-glutamyltransferase increased": 3.5162151285545478, "Hepatic cytolysis": 7.710822488735213, "Hepatitis": 2.614531253140855, "Hepatitis cholestatic": 3.6148948053102288, "Hyperglycaemia": 2.458200316237769, "Hyperkalaemia": 30.76454710029234, "Hypertension": 3.3278259770567447, "Hypertensive crisis": 5.691066606938431, "Hyponatraemia": 10.221168143099996, "Hypotension": 5.173437850702689, "Inappropriate antidiuretic hormone secretion": 5.4333392555809095, "Jaundice": 2.692694845794366, "Lactic acidosis": 8.857360107106622, "Laryngeal oedema": 2.3563820434167293, "Medication error": 3.610546537199228, "Metabolic acidosis": 3.200443283277981, "Mitral valve incompetence": 5.841482451100019, "Multiple organ dysfunction syndrome": 2.071835076797017, "Musculoskeletal chest pain": 5.623627501616175, "Oedema peripheral": 2.092850980641216, "Orthostatic hypotension": 18.56403432181273, "Pancreatitis acute": 3.834222051394935, "Pancytopenia": 2.5661465954962472, "Photosensitivity reaction": 2.9198133270704365, "Pregnancy": 3.8475409051214657, "Product administration error": 2.720537302767459, "Product availability issue": 5.2569617447089545, "Pulmonary arterial hypertension": 4.593257087603842, "Rash vesicular": 2.316157012955151, "Renal failure": 4.175314225542029, "Renal tubular necrosis": 5.4774667936326, "Rhabdomyolysis": 3.719814650151701, "Shock": 4.864251415765066, "Subarachnoid haemorrhage": 2.666400284847539, "Therapy non-responder": 2.702710992373264, "Tongue oedema": 2.743003058774251, "Toxic skin eruption": 2.158757683751209, "Tubulointerstitial nephritis": 4.4593622910221145, "Vasculitis": 3.717432192140981, "Wrong patient received product": 10.504769856100603, "Wrong product administered": 2.118230643852501, "Wrong technique in product usage process": 2.282583730077586}
+{"cytokine release syndrome": 624.42, "cytokine storm": 327.54, "cytopenia": 35.47, "disease progression": 8.44, "encephalopathy": 25.42, "febrile neutropenia": 5.99, "hypogammaglobulinaemia": 132.23, "immune effector cell-associated neurotoxicity syndrome": 842.79, "neurotoxicity": 115.14, "neutropenia": 8.23, "pancytopenia": 12.74, "thrombocytopenia": 5.57}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1060.json

@@ -1 +1 @@
-{"Angioedema": 4.852526923056708, "Blood creatinine increased": 9.11414697954562, "Blood potassium increased": 26.68296229833696, "Blood pressure inadequately controlled": 143.43369787291007, "Blood pressure increased": 8.850686979422518, "Cerebrovascular accident": 2.6342586219275974, "Drug interaction": 2.1225108539429067, "Hyperkalaemia": 6.718051989338982, "Hypertension": 4.070012386267104, "Palpitations": 2.2555678102262497}
+{"alopecia": 2.33, "alpha 1 foetoprotein increased": 150.74, "anaemia": 2.23, "ascites": 6.88, "blister": 4.3, "diarrhoea": 3.25, "disease progression": 4.13, "drug ineffective for unapproved indication": 8.0, "drug intolerance": 2.37, "drug-induced liver injury": 2.74, "erythema multiforme": 6.54, "haematotoxicity": 15.46, "hepatic encephalopathy": 14.76, "hepatic failure": 8.07, "hepatocellular carcinoma": 72.34, "hepatotoxicity": 6.28, "hyperkeratosis": 26.22, "hypertension": 3.53, "hypocalcaemia": 12.63, "metastases to bone": 7.58, "metastases to lung": 32.16, "metastatic renal cell carcinoma": 27.27, "mucosal inflammation": 11.39, "off label use": 6.09, "osteonecrosis of jaw": 14.21, "palmar-plantar erythrodysaesthesia syndrome": 103.78, "product use in unapproved indication": 9.24, "product use issue": 2.69, "rash maculo-papular": 2.75, "renal cell carcinoma": 12.98, "skin exfoliation": 3.25, "skin reaction": 4.31, "skin toxicity": 60.05, "skin ulcer": 6.08, "squamous cell carcinoma of skin": 29.66, "stevens-johnson syndrome": 3.73, "stomatitis": 2.07, "thrombocytopenia": 3.94, "tumour lysis syndrome": 15.07, "weight decreased": 2.45}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1061.json

@@ -1 +1 @@
-{"Anaemia": 20.976499490462054, "Blood creatinine increased": 20.323346852892215, "Drug interaction": 15.697916934734002, "Pruritus": 2.5581282005215877, "Rash": 5.457817515817974, "Thrombocytopenia": 4.147000690645847}
+{"alanine aminotransferase increased": 11.58, "anaemia": 2.14, "aspartate aminotransferase increased": 10.8, "blood bilirubin increased": 10.23, "diarrhoea": 5.77, "disease progression": 11.11, "drug-induced liver injury": 12.73, "hepatic enzyme increased": 7.3, "hepatic function abnormal": 10.18, "hepatotoxicity": 53.44, "liver disorder": 7.99, "liver function test increased": 19.96, "lung adenocarcinoma": 139.46, "lung neoplasm maligt": 5.73, "non-small cell lung cancer": 839.51, "non-small cell lung cancer metastatic": 2514.55, "off label use": 2.27, "pneumonia": 2.03, "therapy partial responder": 89.47}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1062.json

@@ -1 +1 @@
-{"Stevens-Johnson syndrome": 235.45859548184885}
+{"bradycardia": 4.67, "dyspnoea": 2.31, "hypotension": 4.28, "oxygen saturation decreased": 14.79}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1063.json

@@ -1 +1 @@
-{"Drug resistance": 148.29231174476035, "Therapeutic response decreased": 129.52114819956003}
+{"anaemia": 8.54, "ascites": 10.34, "blood bilirubin increased": 6.84, "cerebral haemorrhage": 2.1, "cerebral infarction": 2.85, "depression": 2.08, "drug ineffective": 11.44, "haematemesis": 2.58, "haemoglobin decreased": 7.55, "haemolytic anaemia": 8.24, "hepatic cancer": 3.96, "hepatic cancer recurrent": 701.96, "hepatic cirrhosis": 26.6, "hepatic encephalopathy": 32.04, "hepatic failure": 5.77, "hepatitis": 3.13, "hepatitis b reactivation": 23.49, "hepatitis c": 206.85, "hepatitis c rna positive": 266.32, "hepatocellular carcinoma": 78.3, "hyperbilirubinaemia": 18.12, "jaundice": 6.41, "multiple organ dysfunction syndrome": 2.93, "oesophageal varices haemorrhage": 41.75, "pancreatitis acute": 2.4, "renal impairment": 4.02, "septic shock": 3.08, "treatment failure": 30.55, "treatment noncompliance": 3.44, "viral load increased": 35.38, "virologic failure": 31.91}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1064.json

@@ -1 +1 @@
-{"Acute kidney injury": 3.794996012364297, "Angioedema": 7.017530788545577, "Asthma": 2.969908944251255, "Atrioventricular block complete": 5.830511208547697, "Autonomic neuropathy": 85.42130020171288, "Blood creatine phosphokinase increased": 3.496464806514477, "Blood creatinine increased": 2.3743380964573357, "Blood pressure abnormal": 4.590611781376902, "Blood pressure decreased": 3.355362847262481, "Blood pressure fluctuation": 3.6105456277226993, "Blood pressure inadequately controlled": 42.25598979425666, "Blood pressure increased": 3.3168304021918025, "Blood pressure systolic increased": 3.729874266038971, "Blood urea increased": 3.140265540239677, "Bradycardia": 4.090832288773228, "Cardio-respiratory arrest": 4.826456496855538, "Chest discomfort": 3.261743866805755, "Clostridium difficile infection": 6.492767959112053, "Clumsiness": 44.01255712891343, "Cognitive disorder": 3.492785374209239, "Cough": 2.746835024175105, "Cranial nerve disorder": 95.0725410915532, "Drug interaction": 2.823500108073976, "Drug level increased": 2.8350645496234783, "Drug reaction with eosinophilia and systemic symptoms": 2.4105719907855825, "Electrocardiogram abnormal": 4.918461170090918, "Encephalopathy": 3.8846470810827474, "Forced expiratory flow decreased": 2804.388150094649, "Forced vital capacity decreased": 311.63286284412646, "Full blood count abnormal": 5.310903785908307, "Giant cell arteritis": 34.0285107602632, "Heart rate decreased": 5.281758681616276, "Hypercalcaemia": 8.75568038213015, "Hyperkalaemia": 10.28591351165527, "Hypertensive crisis": 5.356696146564699, "Hypokalaemia": 2.273463676710508, "Hyponatraemia": 4.158363038635899, "Hypotension": 3.0927404476302844, "Illness": 2.153865259770189, "Jaw disorder": 47.529180325284045, "Left ventricular hypertrophy": 12.13198423660111, "Loss of personal independence in daily activities": 4.800037831736784, "Meningitis aseptic": 12.6570295587455, "Mononeuropathy multiplex": 120.48405403877672, "Myelitis": 29.142288020288525, "Nasopharyngitis": 4.014368683866509, "Oedema peripheral": 3.000349987672477, "Oligohydramnios": 27.02468754792876, "Oliguria": 5.370400027937494, "Optic neuropathy": 42.39028228996898, "Oral discomfort": 5.600585268935812, "Orthostatic hypotension": 7.026435944865429, "Peripheral sensorimotor neuropathy": 69.99693825383892, "Peripheral sensory neuropathy": 15.417019349574757, "Product substitution issue": 20.64133703091313, "Product use issue": 3.771594390572568, "Prolonged expiration": 84.50497864567333, "Proteinuria": 2.89361043441058, "Pyelonephritis": 6.255679723179492, "Red blood cell sedimentation rate increased": 9.898958802959395, "Rhabdomyolysis": 2.479783272090896, "SARS-CoV-2 test positive": 3.7698750474433584, "Schizophrenia": 6.0018915112044855, "Shock": 3.060508605316859, "Sjogren's syndrome": 26.32475250699679, "Sleep disorder due to a general medical condition": 19.626837093032712, "Small fibre neuropathy": 52.36215712988933, "Therapeutic product effect incomplete": 5.949670181101318, "Thirst": 2.6013816464191817, "Toxic epidermal necrolysis": 2.0374826664606847, "Toxicity to various agents": 2.565865072581975, "Wheezing": 5.55734223598461}
+{"drug ineffective": 6.03}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1066.json

@@ -1 +1 @@
-{"Thrombocytopenia": 34.068362137670974}
+{"acute respiratory failure": 15.71, "apnoea": 6.66, "aspiration": 35.31, "atelectasis": 36.77, "back pain": 3.73, "brain injury": 7.11, "bronchial secretion retention": 96.28, "bronchiolitis": 16.42, "bronchitis": 3.47, "cardiac arrest": 4.71, "cardio-respiratory arrest": 8.32, "cerebrospinal fluid leakage": 158.68, "choking": 4.72, "chronic respiratory failure": 74.52, "csf pressure increased": 692.88, "csf protein increased": 106.38, "death": 2.57, "dehydration": 2.5, "device dislocation": 17.6, "dysphagia": 3.39, "enterovirus infection": 164.53, "femur fracture": 16.82, "gait inability": 6.53, "gastrointestinal infection": 16.5, "general physical health deterioration": 2.04, "hip fracture": 4.03, "hydrocephalus": 33.58, "hypoxia": 2.46, "increased bronchial secretion": 28.98, "infection": 3.62, "intracranial pressure increased": 21.2, "joint dislocation": 23.06, "lower limb fracture": 6.92, "lower respiratory tract infection": 2.22, "malnutrition": 16.18, "meningitis": 8.3, "meningitis aseptic": 12.38, "mobility decreased": 3.27, "motor dysfunction": 16.26, "muscle contracture": 18.98, "muscular weakness": 2.23, "nasopharyngitis": 2.09, "nephrolithiasis": 5.78, "neurological examination abnormal": 176.02, "neurological procedural complication": 1482.7, "oxygen saturation decreased": 4.68, "parainfluenzae virus infection": 60.09, "pneumonia": 7.73, "pneumonia aspiration": 7.12, "pneumonia viral": 23.04, "pneumothorax": 10.89, "post lumbar puncture syndrome": 5873.49, "post procedural complication": 52.93, "post procedural infection": 20.9, "prescribed underdose": 6.59, "procedural complication": 66.4, "procedural nausea": 215.64, "procedural pain": 267.89, "procedural vomiting": 240.53, "proteinuria": 7.34, "respiratory arrest": 8.01, "respiratory disorder": 20.2, "respiratory distress": 6.31, "respiratory failure": 9.49, "respiratory syncytial virus infection": 37.99, "respiratory tract infection": 30.68, "respiratory tract infection viral": 40.34, "rhinovirus infection": 220.49, "sars-cov-2 test positive": 3.63, "scoliosis": 404.29, "sepsis": 2.93, "spinal deformity": 60.92, "spinal muscular atrophy": 2608.81, "therapeutic product effect decreased": 3.63, "traumatic lumbar puncture": 1620.09, "upper respiratory tract infection": 5.26, "viral infection": 11.64}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1067.json

@@ -1 +1 @@
-{"Acute myeloid leukaemia": 16.04641485252656, "Anaemia": 2.21703539339331, "Aphasia": 3.803726376746415, "Aplastic anaemia": 42.15746161684291, "Astrocytoma": 134.65670303122215, "Astrocytoma malignant": 857.1310857801292, "Astrocytoma, low grade": 470.633906066964, "Bone marrow failure": 22.866841213880523, "Brain oedema": 9.21045529819666, "Cholestasis": 3.2985823658421487, "Cytopenia": 4.79416271297974, "Dermatitis": 3.528543307937692, "Diabetes insipidus": 61.41906402176815, "Disease progression": 16.15421356856522, "Disease recurrence": 13.053283133201347, "Drug ineffective": 2.211162095761864, "Drug reaction with eosinophilia and systemic symptoms": 4.737676161759718, "Drug resistance": 6.000159797207004, "Drug-induced liver injury": 2.7359090555583907, "Eastern Cooperative Oncology Group performance status worsened": 187.3886423931176, "Febrile neutropenia": 5.276576310830276, "Glioblastoma": 355.40828063677634, "Glioblastoma multiforme": 250.3005974242701, "Haematotoxicity": 55.01334121756218, "Hemiparesis": 7.633248053251657, "Hepatic failure": 2.3241201067759727, "Hepatotoxicity": 3.594665722255572, "Hydrocephalus": 16.113104648133792, "Hypermutation": 3989.270212284088, "Hypertransaminasaemia": 7.499914540658484, "Infection": 2.4208713724480457, "Jaundice": 2.7341669762548224, "Leukopenia": 10.17163516166689, "Liver injury": 2.825557141379093, "Lymphopenia": 66.75238665159297, "Malignant neoplasm progression": 9.587188952169704, "Metastasis": 11.842009849091328, "Mucosal inflammation": 3.8913693932643, "Myelodysplastic syndrome": 32.27090725212073, "Myelosuppression": 8.396614169605277, "Neoplasm progression": 10.827016044707758, "Neutropenia": 9.277530940996504, "Pancytopenia": 20.55017296647523, "Petechiae": 3.127501591806748, "Platelet count decreased": 2.332553895473639, "Platelet transfusion": 80.54199615150993, "Pneumocystis jirovecii pneumonia": 17.669069548919932, "Product substitution issue": 2.75563338050983, "Product use in unapproved indication": 3.5859257910295024, "Recurrent cancer": 27.349213887157944, "Seizure": 2.1609611552650967, "Sepsis": 2.5116269997016007, "Skin reaction": 3.122019542635341, "Therapeutic product effect incomplete": 2.276155543131332, "Thrombocytopenia": 26.28776013175121, "Toxicity to various agents": 2.4373725895555034, "Treatment failure": 2.35476778226406, "Tumour pseudoprogression": 488.9504675403912, "Vanishing bile duct syndrome": 133.89355413218908}
+{"acute kidney injury": 11.15, "asthenia": 3.88, "atrial fibrillation": 2.23, "blood creatinine increased": 3.87, "blood potassium increased": 13.98, "bradycardia": 3.8, "dehydration": 4.11, "drug interaction": 3.02, "drug reaction with eosinophilia and systemic symptoms": 11.97, "gynaecomastia": 37.53, "hyperkalaemia": 81.25, "hypokalaemia": 4.21, "hyponatraemia": 11.7, "hypotension": 5.26, "intermenstrual bleeding": 2.31, "metabolic acidosis": 7.21, "oedema peripheral": 3.09, "orthostatic hypotension": 9.46, "product use in unapproved indication": 2.08, "renal impairment": 3.63, "stevens-johnson syndrome": 11.59}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1068.json

@@ -1 +1 @@
-{"Anaemia": 3.950644018200796, "Colitis": 10.273485339860294, "Dehydration": 4.062298553578651, "Disease progression": 7.072765354782429, "Febrile neutropenia": 29.09691853793297, "Hypertriglyceridaemia": 37.08302601852363, "Interstitial lung disease": 5.73365439118869, "Mucosal inflammation": 15.267585899345825, "Myocardial infarction": 4.519647519580414, "Neutropenia": 7.260522026211707, "Neutrophil count decreased": 6.668299049757854, "Overdose": 4.736074388706919, "Pneumonia": 3.099061957816612, "Pneumonitis": 26.033960533213502, "Stomatitis": 47.4149557735368, "Thrombocytopenia": 2.715305727058652, "White blood cell count decreased": 2.618507955041384}
+{"anxiety": 6.57, "blood pressure increased": 8.1, "completed suicide": 6.98, "depersonalisation/derealisation disorder": 30.37, "depressed mood": 3.27, "depression": 10.31, "derealisation": 97.54, "diplopia": 6.82, "dissociation": 946.73, "dissociative disorder": 391.8, "dizziness": 2.53, "drug ineffective": 2.11, "dysarthria": 2.23, "dysgeusia": 5.89, "euphoric mood": 35.11, "fear": 8.84, "feeling abnormal": 5.81, "feeling drunk": 29.6, "hallucination": 5.67, "hallucination, auditory": 9.44, "hallucination, visual": 11.17, "hyperacusis": 16.35, "hypersomnia": 5.18, "hypertension": 3.68, "hypoaesthesia": 2.46, "hypoaesthesia oral": 5.07, "illusion": 30.52, "intentional self-injury": 5.85, "major depression": 33.98, "mania": 5.52, "nasal discomfort": 15.86, "off label use": 2.58, "panic attack": 9.05, "product dose omission issue": 4.34, "psychotic disorder": 3.36, "sedation": 56.2, "sensory disturbance": 5.81, "somnolence": 3.76, "speech disorder": 4.29, "suicidal ideation": 30.48, "suicide attempt": 12.03, "therapeutic product effect decreased": 6.56, "therapeutic response unexpected": 3.75, "throat irritation": 2.32, "underdose": 4.57, "withdrawal syndrome": 2.93}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1069.json

@@ -1 +1 @@
-{"Acute kidney injury": 5.417591513078398, "Alanine aminotransferase increased": 4.80622794631563, "Aspartate aminotransferase increased": 2.6535811939677347, "Blood alkaline phosphatase increased": 2.867471441805755, "Blood bicarbonate decreased": 55.16388215135517, "Blood creatine phosphokinase increased": 4.284897958206766, "Blood creatinine increased": 9.830290059793509, "Blood phosphorus decreased": 85.43367228710261, "Blood urea increased": 8.805888805590932, "Bone pain": 4.274348497211423, "Chronic hepatitis B": 389.0990288891209, "Chronic kidney disease": 14.40086325493597, "Drug ineffective": 2.027192062887665, "Drug resistance": 12.66793728472928, "Drug-induced liver injury": 2.310022693378381, "Fanconi syndrome": 270.4801030760049, "Fanconi syndrome acquired": 274.5703555001742, "Femur fracture": 9.745262188288708, "Foetal exposure during pregnancy": 3.4396858486596025, "Glomerular filtration rate decreased": 26.25382620265648, "Glycosuria": 208.0560519742387, "Hepatitis B": 66.05944286504219, "Hepatitis B DNA increased": 193.33614043315708, "Hepatitis B reactivation": 90.9693594286036, "Hypokalaemia": 4.552127168458829, "Hypophosphataemia": 127.26828519478757, "Hypophosphataemic osteomalacia": 846.721781779316, "Immune reconstitution inflammatory syndrome": 12.867663194107063, "Lactic acidosis": 3.481036080947576, "Maternal exposure during pregnancy": 6.16179687642922, "Metabolic acidosis": 15.265377300721712, "Multiple organ dysfunction syndrome": 2.5388572546855173, "Nephrogenic diabetes insipidus": 40.97437493593878, "Nephropathy toxic": 36.3441495212082, "Osteomalacia": 99.17814845409876, "Osteopenia": 5.189291991228509, "Osteoporosis": 8.634721512900589, "Proteinuria": 24.1606279256998, "Rebound effect": 118.93981745434986, "Renal failure": 3.5900369824311653, "Renal impairment": 13.01960026871292, "Renal tubular acidosis": 160.38798791436352, "Renal tubular disorder": 435.4851892212097, "Renal tubular dysfunction": 371.5404758912924, "Renal tubular necrosis": 22.580582914456304, "Treatment noncompliance": 7.879381013301568, "Tubulointerstitial nephritis": 5.814511798411333, "Viral load increased": 51.89174899445597}
+{"acne": 2.47, "acute lymphocytic leukaemia recurrent": 18.5, "acute pulmonary oedema": 5.05, "adverse event": 13.67, "anaemia": 2.89, "ascites": 3.49, "aspiration pleural cavity": 213.12, "atelectasis": 2.28, "atrial fibrillation": 2.2, "back disorder": 2.84, "blast cell crisis": 125.68, "blast cell proliferation": 214.98, "blast crisis in myelogenous leukaemia": 43.5, "blood disorder": 5.71, "blood test abnormal": 2.42, "bone marrow disorder": 28.36, "bone marrow failure": 4.45, "bone marrow transplant": 49.95, "bone pain": 2.44, "cardiac disorder": 3.04, "cardiac failure": 4.31, "cardiac failure congestive": 4.41, "cardiomegaly": 2.39, "chronic myeloid leukaemia": 29.76, "chronic myeloid leukaemia recurrent": 84.9, "chronic myeloid leukaemia transformation": 59.06, "chylothorax": 279.52, "clostridium difficile infection": 2.64, "colitis": 6.27, "cytomegalovirus enterocolitis": 18.91, "cytomegalovirus infection": 2.27, "cytopenia": 16.17, "death": 3.14, "drug intolerance": 2.3, "drug resistance": 3.29, "dyspnoea exertional": 2.47, "electrocardiogram qt prolonged": 3.52, "enterocolitis": 4.18, "enterocolitis haemorrhagic": 17.15, "fluid retention": 15.1, "folliculitis": 2.1, "full blood count decreased": 12.53, "gallbladder disorder": 2.98, "gastrointestinal disorder": 2.19, "gastrointestinal haemorrhage": 3.29, "gastrointestinal infection": 4.06, "gene mutation": 33.99, "generalised oedema": 3.02, "graft versus host disease": 4.67, "haematochezia": 2.22, "haematotoxicity": 4.07, "haemorrhage": 2.03, "haemothorax": 9.86, "hospitalisation": 12.68, "infection": 2.21, "intentional product use issue": 4.92, "internal haemorrhage": 4.04, "intestinal haemorrhage": 2.78, "iron deficiency anaemia": 2.71, "laboratory test abnormal": 2.24, "leukaemia": 8.27, "leukaemia recurrent": 14.62, "lower gastrointestinal haemorrhage": 2.91, "lung disorder": 2.41, "lung infiltration": 4.75, "lymphocytosis": 9.05, "maligt neoplasm progression": 11.76, "nephrotic syndrome": 4.33, "neuropathy peripheral": 2.93, "neutropenia": 2.1, "oedema": 2.78, "pancytopenia": 6.25, "pericardial effusion": 38.98, "peripheral arterial occlusive disease": 3.55, "philadelphia chromosome positive": 212.22, "platelet count decreased": 3.08, "platelet count increased": 3.69, "pleural effusion": 118.79, "pleurisy": 14.87, "pneumonia": 3.81, "pneumonia fungal": 4.89, "pneumothorax": 2.19, "prescribed underdose": 60.17, "pulmonary alveolar haemorrhage": 2.87, "pulmonary arterial hypertension": 32.61, "pulmonary congestion": 2.23, "pulmonary hypertension": 37.57, "pulmonary oedema": 39.37, "red blood cell count decreased": 3.56, "respiratory tract congestion": 4.6, "retinal haemorrhage": 2.44, "right ventricular failure": 3.62, "splenomegaly": 4.84, "stem cell transplant": 27.73, "subdural haematoma": 3.08, "therapeutic response decreased": 5.15, "therapy non-responder": 5.4, "thrombocytopenia": 3.85, "tooth disorder": 2.29, "transfusion": 9.24, "transplant": 8.94, "tumour lysis syndrome": 3.5, "white blood cell count abnormal": 4.03, "white blood cell count decreased": 2.18, "white blood cell count increased": 3.82}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/107.json

@@ -1 +1 @@
-{"Alanine aminotransferase abnormal": 110.52070008424252, "Alanine aminotransferase increased": 3.219699621697369, "Anal atresia": 952.249070345796, "Anencephaly": 784.0312787137402, "Aspartate aminotransferase abnormal": 209.5312950032599, "Bladder agenesis": 39404.1228813144, "Blood alkaline phosphatase increased": 10.626364852276328, "Blood bilirubin increased": 17.35154857583515, "Blood iron decreased": 123.41799091410346, "Caudal regression syndrome": 2636.088350718861, "Cholelithiasis": 41.75148063711991, "Cloacal exstrophy": 17988.291258625384, "Congenital anomaly": 65.95198645740592, "Congenital ectopic bladder": 5543.213819601852, "Congenital genital malformation": 1569.8309245199737, "Congenital musculoskeletal disorder": 547.0517563409115, "Congenital musculoskeletal disorder of spine": 1140.4637512091592, "Drug-induced liver injury": 6.756263211682231, "Erythema": 2.7625540431608644, "Exomphalos": 901.5852294731764, "Exposure during pregnancy": 5.743266026759097, "Fibrosis": 124.22201749932825, "Foetal exposure during pregnancy": 5.654519907981118, "Gastrointestinal disorder congenital": 4701.065232172242, "Gastrointestinal malformation": 1714.2496582015333, "Genitalia external ambiguous": 3472.013490665753, "Hepatic cytolysis": 10.8942409411567, "Hepatic enzyme increased": 7.6700180362842625, "Hepatotoxicity": 12.607378882023747, "Hypomania": 58.1016134272866, "Jaundice": 19.5686164861567, "Jaundice cholestatic": 51.086931422449055, "Lipodystrophy acquired": 313.1885069513086, "Pneumonia": 3.698393232766496, "Premature labour": 50.64353106010293, "Product use in unapproved indication": 2.6649504644446664, "Psychotic disorder": 9.227838194335083, "Schizophrenia": 116.30765672503898, "Tinnitus": 3.683780988840986, "Vomiting": 2.3335272778467693}
+{"acute kidney injury": 2.12, "adrenal insufficiency": 10.45, "alanine aminotransferase increased": 4.65, "aspartate aminotransferase increased": 3.94, "blood bilirubin increased": 2.4, "blood pressure increased": 2.68, "blood thyroid stimulating hormone increased": 13.61, "colitis": 2.94, "decreased appetite": 2.97, "dehydration": 2.03, "diarrhoea": 4.82, "disease progression": 6.32, "drug-induced liver injury": 4.74, "dysphonia": 13.08, "general physical health deterioration": 3.66, "hepatic function abnormal": 4.47, "hepatitis": 14.32, "hepatotoxicity": 13.58, "hyperkalaemia": 2.24, "hypertension": 10.5, "hyperthyroidism": 5.62, "hypertransaminasaemia": 10.21, "hypothyroidism": 31.07, "immune-mediated hepatic disorder": 64.52, "immune-mediated hypothyroidism": 51.1, "immune-mediated myocarditis": 35.77, "liver disorder": 2.69, "liver function test increased": 3.78, "maligt neoplasm progression": 14.87, "metastatic renal cell carcinoma": 26.6, "mucosal inflammation": 10.61, "neoplasm progression": 31.69, "off label use": 2.51, "osteonecrosis of jaw": 12.5, "palmar-plantar erythrodysaesthesia syndrome": 31.0, "pancreatitis acute": 2.45, "pneumonitis": 3.46, "polycythaemia": 43.29, "posterior reversible encephalopathy syndrome": 23.69, "product use in unapproved indication": 2.36, "proteinuria": 11.88, "stomatitis": 5.74, "therapy partial responder": 32.64, "thyroiditis": 17.0, "transaminases increased": 5.58, "tubulointerstitial nephritis": 6.25, "weight decreased": 3.12}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1070.json

@@ -1 +1 @@
-{"Acute graft versus host disease": 465.04008749833, "Graft versus host disease": 383.9366784620941, "Mucosal inflammation": 61.453650752156}
+{"drug interaction": 23.45}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1071.json

@@ -1 +1 @@
-{"Nausea": 3.5380030778930496}
+{"abnormal behaviour": 2.9, "aggression": 3.51, "agitation": 3.51, "akinesia": 60.66, "aspiration": 6.78, "blood creatine phosphokinase increased": 2.01, "choking": 6.06, "chromaturia": 22.25, "colitis microscopic": 24.32, "confusional state": 4.22, "dehydration": 2.21, "delirium": 4.73, "delusion": 6.04, "dementia": 5.82, "disease progression": 3.63, "disorientation": 3.59, "dopamine dysregulation syndrome": 201.05, "dyskinesia": 28.17, "dysphagia": 21.4, "dysstasia": 5.74, "dystonia": 8.95, "fall": 4.21, "feeding disorder": 3.06, "feeling abnormal": 2.09, "femur fracture": 3.67, "fracture": 9.76, "freezing phenomenon": 74.07, "gait disturbance": 3.85, "gait inability": 4.44, "general physical health deterioration": 3.93, "hallucination": 12.22, "hallucination, auditory": 3.85, "hallucination, visual": 16.88, "head injury": 2.23, "hip fracture": 4.12, "hypersexuality": 45.62, "hypokinesia": 12.0, "ileus": 7.42, "movement disorder": 6.43, "muscle rigidity": 16.99, "musculoskeletal stiffness": 3.75, "nervousness": 2.65, "neuroleptic maligt syndrome": 4.17, "on and off phenomenon": 220.32, "oral mucosal discolouration": 81.06, "orthostatic hypotension": 7.16, "paralysis": 3.97, "paranoia": 7.66, "parkinson's disease": 204.52, "parkinsonian crisis": 804.44, "parkinsonism": 8.38, "pneumonia aspiration": 7.97, "product complaint": 21.73, "product prescribing error": 5.6, "product quality issue": 2.3, "product residue present": 9.74, "product size issue": 24.73, "product supply issue": 32.35, "product use complaint": 11.69, "psychomotor hyperactivity": 6.54, "psychotic disorder": 4.33, "rhabdomyolysis": 3.35, "salivary hypersecretion": 5.52, "speech disorder": 4.37, "therapeutic product effect decreased": 3.55, "therapeutic response shortened": 37.46, "therapy cessation": 7.53, "tremor": 4.1, "urinary tract infection": 2.2, "weight decreased": 2.52, "wrong technique in product usage process": 17.22}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1072.json

@@ -1 +1 @@
-{"Alanine aminotransferase increased": 2.27424550433732, "Alopecia": 5.218457105556481, "Back pain": 2.35408132758621, "Balance disorder": 4.788713031039936, "Depressed mood": 3.6773538294595913, "Fall": 3.459173184360765, "Gait disturbance": 3.3533611742158804, "Hepatic enzyme increased": 3.7271520613998126, "Hypoaesthesia": 3.1773718405128504, "Memory impairment": 3.1825561538104483, "Multiple sclerosis": 35.87273619557571, "Multiple sclerosis relapse": 74.31171249524328, "Product substitution issue": 14.914393889373814, "Unevaluable event": 7.398559640031065, "Urinary tract infection": 3.0511830535556634}
+{"alanine aminotransferase increased": 5.6, "aspartate aminotransferase increased": 6.51, "blood glucose increased": 5.13, "gamma-glutamyltransferase increased": 10.48, "hypoglycaemia": 24.58}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1073.json

@@ -1 +1 @@
-{"Back pain": 3.2535292471658583, "Bone pain": 4.1287137660365465, "Calciphylaxis": 159.30080992833138, "Fall": 5.765425314138002, "Femur fracture": 16.10478800098519, "Hip fracture": 15.484716274988267, "Hospitalisation": 2.0386633959000635, "Hypercalcaemia": 76.67013068304536, "Muscle spasms": 2.469262203061878, "Nephrolithiasis": 6.143134211067866, "Renal impairment": 2.354725013778273, "Skin necrosis": 19.31323140631608, "Spinal compression fracture": 18.35043349921976, "Spinal fracture": 13.013928960845346, "Upper limb fracture": 19.51463055554854}
+{"lactic acidosis": 80.9}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1074.json

@@ -1 +1 @@
-{"Back pain": 4.502696978429284, "Bone pain": 6.888177846802693, "Device malfunction": 17.42239485942071, "Dizziness": 2.975360160046048, "Injection site bruising": 42.52910538142604, "Injection site erythema": 4.430756947462962, "Injection site haemorrhage": 26.57497786214627, "Muscle spasms": 3.495796094787281, "Nausea": 2.087133447193419, "Pain in extremity": 2.7383340065924853, "Palpitations": 3.018722676984012, "Product dose omission issue": 5.198305610758029, "Therapy interrupted": 62.73146371117658, "Wrong technique in device usage process": 44.20027338226655}
+{"death": 5.13}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1075.json

@@ -1 +1 @@
-{"Accidental exposure to product": 12.080499856820271, "Acne": 9.440369199313349, "Acute myocardial infarction": 17.576976517201253, "Aggression": 4.498486436025834, "Anger": 5.383876922768514, "Angina pectoris": 2.889259044182473, "Aortic aneurysm": 18.17837141989954, "Arteriosclerosis": 10.676505452687696, "Atrial fibrillation": 2.0034923906712687, "Blood testosterone decreased": 85.91153653197748, "Blood testosterone increased": 412.3866340747055, "Bone disorder": 7.113804647529053, "Breast cancer": 3.892036576317762, "Breast cancer metastatic": 8.902801016524183, "Cardiac death": 98.66579407767033, "Cardiac failure congestive": 2.172523167707363, "Cardiomyopathy": 7.362062427575814, "Cerebrovascular accident": 4.418975651837623, "Cholestasis": 3.101375735972487, "Coronary artery disease": 11.646528459185175, "Coronary artery occlusion": 6.848311564568541, "Deep vein thrombosis": 15.422624290547953, "Device dislocation": 34.05992900066411, "Device malfunction": 6.032849269129476, "Drug abuse": 12.926828588353708, "Drug-induced liver injury": 2.559959420775908, "Dyslipidaemia": 9.386557677931464, "Endometrial cancer": 45.62416534941225, "Erectile dysfunction": 5.835781165615611, "Gynaecomastia": 7.10372429034173, "Hair growth abnormal": 28.38329845833128, "Idiopathic intracranial hypertension": 65.5316144352414, "Intentional product misuse": 3.0406896463845103, "Invasive ductal breast carcinoma": 17.39926159304209, "Jaundice": 3.0760270732134494, "Left ventricular hypertrophy": 46.41696567317301, "Libido decreased": 7.04483245600222, "Mesenteric vein thrombosis": 49.82377531698251, "Muscle mass": 194.53045341531097, "Myocardial fibrosis": 91.75883416578648, "Myocardial infarction": 4.292764777491754, "Obstructive sleep apnoea syndrome": 27.240806841862785, "Oestradiol increased": 181.24167592430973, "Off label use": 2.683094544723802, "Osteonecrosis": 3.183937228998872, "Papilloedema": 18.124087432693496, "Polycythaemia": 193.6453657717842, "Portal vein thrombosis": 22.914358530816408, "Precocious puberty": 179.91027558289872, "Prescription drug used without a prescription": 22.59359349114965, "Product quality issue": 13.846996295569904, "Product use in unapproved indication": 2.859849532029431, "Product use issue": 7.471237596419519, "Prostate cancer": 6.6830260146961855, "Prostatic specific antigen increased": 9.965604403503, "Pulmonary embolism": 9.053819098044029, "Self-medication": 58.86283737018609, "Testicular atrophy": 130.55584368399477, "Therapeutic product effect decreased": 2.214050043694165, "Thrombosis": 2.8968926194906124, "Transgender hormonal therapy": 3969.856152227744, "Virilism": 925.5841314939246}
+{"diabetic ketoacidosis": 54.51, "fournier's gangrene": 194.79, "urinary tract infection": 9.55}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1076.json

@@ -1 +1 @@
-{"Bone pain": 27.846789229238368, "Drug ineffective": 7.129510721873197, "Erythema": 6.323156581725332}
+{"genital infection fungal": 692.32, "urinary tract infection": 24.72}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1077.json

@@ -1 +1 @@
-{"Product use in unapproved indication": 20.188251769515823}
+{"abdominal abscess": 6.1, "abortion spontaneous": 4.3, "abscess": 5.61, "accidental exposure to product": 6.24, "adenocarcinoma of colon": 13.46, "alopecia": 2.27, "alopecia areata": 3.33, "anal abscess": 18.79, "anal fistula": 33.18, "ankylosing spondylitis": 3.14, "arthritis": 4.02, "arthropathy": 3.02, "b-cell lymphoma": 4.14, "basal cell carcinoma": 9.09, "breast mass": 2.09, "bronchitis": 2.13, "caesarean section": 2.51, "cellulitis": 4.08, "cervical dysplasia": 4.81, "chikungunya virus infection": 43.42, "cholecystectomy": 5.34, "clostridium difficile infection": 5.84, "colectomy": 17.08, "colitis ulcerative": 25.4, "colon cancer": 3.74, "crohn's disease": 144.81, "cutaneous t-cell lymphoma": 12.77, "cutaneous vasculitis": 3.6, "dactylitis": 16.56, "decreased immune responsiveness": 2.85, "defaecation urgency": 4.29, "dermatitis exfoliative": 4.03, "dermatitis exfoliative generalised": 4.05, "device defective": 4.2, "device deployment issue": 43.11, "device issue": 4.37, "device leakage": 3.26, "diarrhoea haemorrhagic": 2.13, "dilated cardiomyopathy": 4.65, "disability": 2.11, "diverticulitis": 2.91, "drug delivery system malfunction": 5.71, "drug ineffective": 3.81, "drug level below therapeutic": 15.43, "drug level decreased": 12.82, "ear infection": 2.16, "eosinophilic pneumonia": 2.44, "erysipelas": 6.79, "erythema nodosum": 2.67, "erythrodermic psoriasis": 43.1, "exposure during pregcy": 8.2, "faecal calprotectin abnormal": 118.12, "faecal calprotectin increased": 25.6, "female genital tract fistula": 10.6, "fistula": 33.28, "frequent bowel movements": 4.65, "gastrointestinal infection": 3.35, "gastrointestinal inflammation": 2.8, "gingivitis": 2.25, "guttate psoriasis": 29.07, "haematochezia": 2.7, "hepatic cirrhosis": 3.04, "hepatic steatosis": 2.35, "hepatitis c": 2.17, "hernia": 5.44, "herpes virus infection": 3.42, "hidradenitis": 6.29, "hip arthroplasty": 3.18, "hiv infection": 6.68, "hodgkin's disease": 6.05, "hysterectomy": 5.28, "iga nephropathy": 8.33, "ileal stenosis": 35.14, "ileostomy": 19.07, "immunosuppression": 2.61, "inappropriate schedule of product administration": 6.33, "incorrect route of product administration": 2.26, "infection": 2.32, "inflammatory bowel disease": 11.81, "infusion related reaction": 11.94, "intestinal obstruction": 7.54, "intestinal operation": 30.27, "intestinal perforation": 2.92, "intestinal resection": 33.07, "intestinal stenosis": 92.29, "invasive ductal breast carcinoma": 2.87, "iron deficiency anaemia": 2.41, "kidney infection": 2.65, "knee arthroplasty": 4.38, "knee operation": 4.96, "large intestinal stenosis": 17.93, "latent tuberculosis": 58.89, "lipoma": 5.7, "liquid product physical issue": 3.89, "loss of therapeutic response": 44.65, "lower respiratory tract infection": 5.44, "lung adenocarcinoma": 8.29, "lupus-like syndrome": 6.76, "lymphoma": 3.66, "maligt melanoma": 9.08, "maligt melanoma in situ": 7.97, "malnutrition": 2.05, "mycobacterium tuberculosis complex test positive": 56.22, "myocardial infarction": 2.43, "needle issue": 13.41, "nephrolithiasis": 3.13, "non-hodgkin's lymphoma": 2.02, "off label use": 6.37, "osteomyelitis": 2.36, "papilloma viral infection": 6.25, "paternal exposure during pregcy": 18.95, "pemphigoid": 2.04, "periodontitis": 6.32, "pharyngitis": 2.04, "pneumonia": 2.08, "poor quality product administered": 3.23, "posterior reversible encephalopathy syndrome": 3.92, "premature labour": 3.54, "product dose omission issue": 8.97, "product label issue": 5.73, "product leakage": 2.59, "product packaging issue": 4.75, "product storage error": 7.74, "product use in unapproved indication": 2.59, "product use issue": 11.8, "psoriasis": 49.94, "psoriasis area severity index increased": 68.37, "psoriatic arthropathy": 49.83, "pustular psoriasis": 41.59, "pyoderma gangrenosum": 14.17, "rash pustular": 2.55, "rectal abscess": 34.08, "rectal cancer": 8.27, "respiratory tract infection": 3.53, "sacroiliitis": 9.58, "sarcoidosis": 4.39, "sinusitis": 2.11, "skin cancer": 2.18, "skin exfoliation": 2.09, "skin infection": 3.18, "skin plaque": 2.56, "small intestinal obstruction": 7.03, "spinal operation": 2.99, "squamous cell carcinoma": 11.37, "squamous cell carcinoma of skin": 4.39, "staphylococcal infection": 4.84, "streptococcal infection": 5.05, "subcutaneous abscess": 4.17, "surgery": 7.67, "syringe issue": 45.78, "therapeutic product effect decreased": 7.72, "therapeutic product effect incomplete": 2.08, "therapeutic product ineffective": 4.38, "therapeutic response decreased": 16.51, "therapeutic response shortened": 4.07, "therapy non-responder": 5.9, "tonsillitis": 2.99, "tooth abscess": 9.32, "tooth infection": 5.53, "transitional cell carcinoma": 12.99, "treatment noncompliance": 2.24, "tuberculin test positive": 82.34, "tuberculosis": 12.5, "underdose": 2.36, "upper respiratory tract infection": 4.35, "viral infection": 2.95, "vitiligo": 8.3, "weight increased": 2.02}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1078.json

@@ -1 +1 @@
-{}
+{"acute kidney injury": 2.8}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1079.json

@@ -1 +1 @@
-{"Asthma": 32.77069085038518}
+{"decreased appetite": 12.22}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1080.json

@@ -1 +1 @@
-{"Acute lymphocytic leukaemia": 15.812596111587196, "Acute myeloid leukaemia": 5.498676222119293, "Acute myocardial infarction": 2.51947590093894, "Atelectasis": 5.550066240676565, "Bone disorder": 4.40870021513675, "Bone lesion": 21.1461499036955, "Bradycardia": 4.764114806166199, "Cardiac failure": 2.8863827873838788, "Constipation": 4.409454140698935, "Cutaneous vasculitis": 5.137814944953071, "Cytopenia": 3.35882551348306, "Death": 3.432036286069746, "Deep vein thrombosis": 12.461071063351248, "Disease progression": 5.423874211474828, "Disorientation": 2.00625300028967, "Drug intolerance": 2.168788886952251, "Drug reaction with eosinophilia and systemic symptoms": 5.232076000148883, "Dysaesthesia": 4.974378184157472, "Embolism": 9.526398187641204, "Febrile neutropenia": 3.443644831636957, "Infection": 2.6350909874578123, "Myelodysplastic syndrome": 6.728775349883188, "Neuropathy peripheral": 36.88426625742378, "Neurotoxicity": 4.854351083876428, "Neutropenia": 2.935639048713188, "Oedema": 2.486531273173087, "Oedema peripheral": 3.145100618655224, "Orthostatic hypotension": 3.313278862760212, "Osteonecrosis of jaw": 12.31537943769507, "Pancytopenia": 4.191613805125339, "Paraesthesia": 2.486029349456597, "Peripheral motor neuropathy": 68.0896975870547, "Peripheral sensory neuropathy": 86.03693107542922, "Plasma cell myeloma": 49.61178118538482, "Plasma cell myeloma recurrent": 46.55714078620445, "Plasmacytoma": 74.41602336223518, "Pneumonia": 2.0727183197664885, "Pneumonitis": 2.956133445462064, "Polyneuropathy": 23.35385164384917, "Pulmonary embolism": 8.641650065482954, "Pulmonary hypertension": 2.786863653378804, "Rash maculo-papular": 3.2109750819015503, "Renal impairment": 2.2589405225942327, "Sepsis": 4.265431141318596, "Septic shock": 2.9667337358143904, "Sinus bradycardia": 4.420869636439437, "Therapy non-responder": 9.95303065310162, "Toxic skin eruption": 3.851538552788668, "Transient ischaemic attack": 2.8797802067650737, "Tumour lysis syndrome": 8.188848339258541, "Type 2 lepra reaction": 200.82207246801983, "Varicella zoster virus infection": 25.852618001457504, "Venous thrombosis limb": 11.007824549815108}
+{"acute hepatic failure": 3.2, "adenocarcinoma of colon": 36.1, "alanine aminotransferase increased": 5.24, "ammonia increased": 8.75, "aphonia": 2.07, "ascites": 9.0, "aspartate aminotransferase increased": 7.05, "asthenia": 2.35, "bilirubin conjugated increased": 5.81, "blister": 5.55, "blood albumin decreased": 3.43, "blood alkaline phosphatase increased": 2.2, "blood bilirubin increased": 18.71, "blood lactate dehydrogenase increased": 2.21, "blood pressure increased": 2.43, "blood thyroid stimulating hormone increased": 5.41, "c-reactive protein increased": 3.66, "cancer pain": 12.0, "carbohydrate antigen 19-9 increased": 38.22, "carcinoembryonic antigen increased": 87.89, "cholangitis": 6.14, "cholecystitis": 3.21, "chromaturia": 2.75, "colon cancer": 44.07, "colon cancer metastatic": 85.18, "colon cancer recurrent": 119.02, "colorectal cancer": 4.24, "colorectal cancer metastatic": 506.49, "death": 2.29, "decreased appetite": 3.83, "dermatitis bullous": 2.27, "dermatitis exfoliative generalised": 3.18, "diarrhoea": 2.28, "disease progression": 2.28, "disseminated intravascular coagulation": 8.19, "drug eruption": 7.43, "drug-induced liver injury": 5.24, "dry skin": 2.07, "dysphonia": 13.66, "eating disorder": 2.3, "erythema multiforme": 13.29, "gastrointestinal perforation": 28.53, "gastrointestinal stromal tumour": 38.67, "general physical health deterioration": 3.3, "hepatic encephalopathy": 18.26, "hepatic failure": 9.16, "hepatic function abnormal": 11.08, "hepatitis fulmit": 7.18, "hepatocellular carcinoma": 27.52, "hepatotoxicity": 5.64, "hydronephrosis": 3.85, "hyperammonaemia": 4.34, "hyperbilirubinaemia": 10.05, "hyperkeratosis": 23.59, "hypertension": 5.0, "hypertransaminasaemia": 2.56, "hypoalbuminaemia": 5.5, "hypocalcaemia": 2.79, "hypophagia": 2.81, "hypophosphataemia": 6.77, "hypothyroidism": 5.19, "ileus": 4.71, "intestinal obstruction": 3.32, "intestinal perforation": 4.77, "jaundice": 7.77, "liver disorder": 6.47, "liver function test abnormal": 2.54, "liver function test increased": 4.86, "liver injury": 3.26, "melaena": 2.43, "metastases to bone": 5.03, "metastases to central nervous system": 9.83, "metastases to liver": 27.79, "metastases to lung": 45.84, "metastases to lymph nodes": 15.83, "metastases to peritoneum": 27.29, "metastasis": 5.13, "mouth ulceration": 3.23, "mucosal inflammation": 11.14, "nephrotic syndrome": 3.44, "ocular icterus": 7.32, "off label use": 7.36, "oral pain": 2.95, "pain of skin": 9.35, "palmar-plantar erythrodysaesthesia syndrome": 138.35, "performance status decreased": 3.29, "peritonitis": 3.47, "plantar erythema": 49.13, "platelet count decreased": 8.28, "posterior reversible encephalopathy syndrome": 7.2, "proctalgia": 4.92, "protein urine present": 14.06, "proteinuria": 10.69, "pulmonary mass": 3.2, "rash maculo-papular": 2.83, "rash papular": 2.02, "rectal adenocarcinoma": 43.86, "rectal cancer": 38.9, "rectal cancer metastatic": 114.48, "renal impairment": 2.09, "skin disorder": 2.39, "skin exfoliation": 9.09, "skin fissures": 13.46, "skin induration": 10.3, "skin swelling": 5.81, "skin toxicity": 24.1, "skin ulcer": 4.97, "skin warm": 2.19, "stevens-johnson syndrome": 2.5, "stoma site haemorrhage": 45.41, "stomatitis": 7.54, "thrombocytopenia": 2.22, "toxic skin eruption": 2.52, "transaminases increased": 3.34, "tumour haemorrhage": 14.44, "tumour marker increased": 17.17, "weight decreased": 2.27, "yellow skin": 3.45}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1081.json

@@ -1 +1 @@
-{"Acute lymphocytic leukaemia": 200.72756871358172, "Decreased appetite": 4.9754642239342735, "Febrile neutropenia": 17.563989664438253, "Leukopenia": 10.74683880596742, "Mucosal inflammation": 27.58822158590593, "Myelosuppression": 6.927597858062939, "Stomatitis": 13.94546001504778, "Vomiting": 2.3064690029664376}
+{"hepatic function abnormal": 9.72, "insomnia": 3.0, "liver injury": 25.53, "pregcy": 68.06, "pruritus": 2.48, "rash": 6.91}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1082.json

@@ -1 +1 @@
-{}
+{"blood alkaline phosphatase increased": 29.57, "bone pain": 3.99, "condition aggravated": 4.12, "contusion": 3.09, "craniosynostosis": 293.21, "femur fracture": 16.36, "hypophosphatasia": 5775.62, "injection site atrophy": 227.68, "injection site bruising": 12.25, "injection site erythema": 5.55, "injection site pruritus": 4.91, "injection site reaction": 15.8, "injection site urticaria": 22.34, "lipodystrophy acquired": 144.96, "nephrocalcinosis": 223.29, "nephrolithiasis": 7.35}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1083.json

@@ -1 +1 @@
-{"Acute graft versus host disease": 40.98962384468704, "Acute graft versus host disease in intestine": 162.54282149464166, "Acute graft versus host disease in skin": 191.7586418440809, "Acute promyelocytic leukaemia": 80.76217224837043, "Acute respiratory distress syndrome": 17.10351741163306, "Adenovirus infection": 53.87190121599772, "Anaemia": 4.726986018840199, "Aplastic anaemia": 16.247896771933043, "Chronic graft versus host disease": 39.84050064061359, "Chronic graft versus host disease in skin": 192.51735717586604, "Cystitis haemorrhagic": 41.35647694111013, "Cytomegalovirus infection reactivation": 80.80282490665593, "Deafness": 18.3052108148416, "Febrile neutropenia": 20.523005794198767, "Focal nodular hyperplasia": 679.6024211412794, "Graft versus host disease in gastrointestinal tract": 177.81909816834084, "Graft versus host disease in skin": 66.86096760754364, "Haematotoxicity": 34.0783825233434, "Hepatotoxicity": 15.106087171396371, "Leukopenia": 2.961004387297439, "Medulloblastoma recurrent": 2815.918222338205, "Mucosal inflammation": 62.6153191884963, "Multiple organ dysfunction syndrome": 4.057598456527057, "Myelodysplastic syndrome": 13.236047168380043, "Myelosuppression": 4.700370594290437, "Nervous system disorder": 14.202169728341207, "Neurotoxicity": 10.093362038127054, "Neutropenia": 14.358787677272758, "Off label use": 3.175916712856761, "Osteosarcoma": 502.9693174763792, "Pancytopenia": 2.3438655669244155, "Platelet count decreased": 2.7444765210459163, "Pneumonia cytomegaloviral": 65.051301155106, "Product use in unapproved indication": 5.141070670342077, "Pulmonary arterial hypertension": 17.042966491558634, "Respiratory distress": 3.198589154126713, "Second primary malignancy": 28.662096829500527, "Sepsis": 5.875374627324435, "Short stature": 605.5471836042957, "Stomatitis": 5.199218308356958, "Thrombocytopenia": 13.791380866636636, "Thrombotic microangiopathy": 28.27481572516789, "Venoocclusive liver disease": 49.76301641465533, "Visual impairment": 6.677342690487749}
+{"acute kidney injury": 4.87, "anhedonia": 66.53, "ankle fracture": 18.26, "anxiety": 11.33, "blood creatinine increased": 8.46, "blood hiv rna increased": 14.86, "bone demineralisation": 88.61, "bone density abnormal": 96.14, "bone density decreased": 105.01, "bone disorder": 13.07, "bone loss": 108.11, "cd4 lymphocytes decreased": 15.54, "chronic kidney disease": 60.28, "clavicle fracture": 9.56, "decreased activity": 8.84, "degenerative bone disease": 60.36, "dental caries": 4.22, "depression": 2.58, "drug resistance": 3.95, "dysstasia": 3.1, "economic problem": 81.15, "emotional distress": 54.11, "end stage renal disease": 16.51, "fanconi syndrome acquired": 22.22, "femur fracture": 3.93, "fibula fracture": 14.87, "foot fracture": 17.38, "fracture": 30.88, "genotype drug resistance test positive": 19.52, "glomerular filtration rate abnormal": 26.3, "glomerular filtration rate decreased": 8.1, "hand fracture": 30.88, "hip arthroplasty": 10.16, "hip fracture": 4.78, "immune reconstitution inflammatory syndrome": 9.32, "intervertebral disc degeneration": 6.84, "loss of personal independence in daily activities": 4.04, "lower limb fracture": 6.55, "multiple fractures": 93.94, "nephrolithiasis": 3.56, "nephropathy": 22.94, "nephropathy toxic": 28.78, "osteoarthritis": 4.69, "osteomalacia": 21.68, "osteonecrosis": 86.92, "osteopenia": 65.64, "osteoporosis": 62.36, "pain": 4.69, "protein total abnormal": 66.98, "protein total increased": 18.46, "protein urine present": 9.97, "proteinuria": 5.57, "quality of life decreased": 9.63, "renal disorder": 2.07, "renal failure": 21.84, "renal impairment": 6.94, "renal injury": 68.13, "renal tubular disorder": 9.51, "rib fracture": 13.05, "shoulder fracture": 7.4, "skeletal injury": 71.01, "spinal compression fracture": 7.68, "spinal fracture": 9.78, "spinal osteoarthritis": 9.67, "teeth brittle": 28.09, "tibia fracture": 10.95, "tooth disorder": 2.91, "tooth fracture": 29.28, "tooth loss": 92.0, "treatment noncompliance": 2.23, "upper limb fracture": 6.18, "viral load increased": 19.45, "viral mutation identified": 16.65, "virologic failure": 17.11, "vitamin d deficiency": 26.55, "wrist fracture": 13.33}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1084.json

@@ -1 +1 @@
-{"Abortion spontaneous": 227.04082780582536, "Maternal exposure during pregnancy": 96.34696146561234}
+{"abortion induced": 7.6, "abortion spontaneous": 12.48, "accident": 4.98, "accidental exposure to product": 6.04, "accidental exposure to product by child": 44.9, "accidental overdose": 3.2, "adverse event": 4.5, "affective disorder": 2.51, "alcohol abuse": 53.01, "ankle fracture": 4.3, "anxiety": 2.62, "arthropathy": 2.72, "attention deficit hyperactivity disorder": 4.39, "back disorder": 5.55, "back injury": 4.75, "bipolar disorder": 2.91, "brain injury": 4.16, "completed suicide": 2.08, "concussion": 3.99, "craniofacial fracture": 7.57, "dental caries": 15.78, "dependence": 6.34, "depression": 3.26, "detoxification": 107.28, "developmental delay": 4.1, "disability": 4.21, "drug abuse": 14.19, "drug dependence": 19.88, "drug detoxification": 518.75, "drug diversion": 58.7, "drug effect less than expected": 9.48, "drug ineffective for unapproved indication": 2.97, "drug screen negative": 182.77, "drug screen positive": 31.7, "drug withdrawal syndrome": 64.32, "drug withdrawal syndrome neonatal": 143.52, "endocarditis": 7.76, "euphoric mood": 18.35, "exposure during pregcy": 11.66, "exposure via breast milk": 37.27, "extra dose administered": 2.52, "feeling abnormal": 2.72, "feeling of body temperature change": 4.93, "foetal distress syndrome": 6.06, "foetal exposure during pregcy": 22.16, "foetal exposure via father": 72.04, "foetal growth restriction": 6.1, "foot fracture": 4.29, "formication": 2.29, "gallbladder disorder": 6.17, "gestational diabetes": 5.89, "gun shot wound": 30.01, "hallucination": 3.12, "hallucination, auditory": 4.04, "hallucination, visual": 2.83, "hand fracture": 5.05, "head injury": 2.51, "hepatic cirrhosis": 2.17, "hepatitis c": 9.77, "homicidal ideation": 5.1, "homicide": 15.75, "hospitalisation": 5.38, "impaired driving ability": 8.1, "inappropriate schedule of product administration": 4.58, "inappropriate schedule of product discontinuation": 144.59, "infantile diarrhoea": 41.72, "insomnia": 2.48, "intentional product misuse": 7.09, "intentional product use issue": 6.65, "intentional underdose": 226.65, "intervertebral disc degeneration": 3.38, "intervertebral disc protrusion": 3.67, "irritability": 2.15, "jaundice neonatal": 57.72, "joint injury": 4.4, "learning disability": 8.56, "libido decreased": 2.36, "limb injury": 3.01, "loss of consciousness": 2.47, "low birth weight baby": 19.89, "lower limb fracture": 4.05, "major depression": 3.1, "maternal exposure during pregcy": 11.5, "mental disorder": 3.77, "mental impairment": 2.04, "miosis": 5.6, "neonatal disorder": 35.59, "nerve compression": 4.36, "no adverse event": 2.11, "oral administration complication": 61.6, "overdose": 7.59, "panic attack": 2.73, "paranoia": 7.28, "pharyngeal swelling": 3.54, "poor feeding infant": 11.73, "post-traumatic stress disorder": 4.78, "pre-eclampsia": 8.78, "premature baby": 12.98, "premature delivery": 33.96, "premature labour": 22.61, "premature rupture of membranes": 7.45, "premature separation of placenta": 9.69, "prescribed overdose": 5.1, "procedural pain": 33.3, "product preparation issue": 320.38, "product use issue": 4.4, "psychomotor hyperactivity": 3.96, "psychotic disorder": 2.47, "respiratory depression": 7.65, "restless legs syndrome": 2.11, "restlessness": 2.03, "rib fracture": 7.3, "road traffic accident": 16.97, "seizure": 2.61, "selective eating disorder": 18.1, "skin laceration": 2.89, "sleep apnoea syndrome": 3.69, "small for dates baby": 8.89, "sneezing": 2.5, "spinal fracture": 3.8, "staphylococcal infection": 2.11, "stillbirth": 5.69, "substance abuse": 147.39, "substance use disorder": 5.9, "suicidal ideation": 5.88, "swollen tongue": 2.06, "therapeutic product ineffective": 16.62, "therapeutic response unexpected": 4.47, "therapy interrupted": 12.06, "therapy naive": 197.48, "tooth disorder": 5.53, "tooth fracture": 6.12, "tooth loss": 2.34, "toothache": 2.46, "toxicity to various agents": 5.47, "tremor neonatal": 61.32, "underdose": 11.76, "unevaluable event": 3.3, "unresponsive to stimuli": 3.37, "upper limb fracture": 5.55, "uterine disorder": 14.1, "withdrawal syndrome": 6.28, "wrist fracture": 4.19, "wrong technique in product usage process": 7.65, "yawning": 7.06}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1085.json

@@ -1 +1 @@
-{"Acute coronary syndrome": 4.833472647267703, "Acute kidney injury": 2.468818293486269, "Acute myocardial infarction": 8.448810431637515, "Amaurosis": 39.52333191306073, "Angina unstable": 5.615154263583051, "Asphyxia": 37.63570374965063, "Atrioventricular block": 5.77635850162484, "Atrioventricular block complete": 6.731418726769471, "Blood loss anaemia": 50.74725054408197, "Bronchial haemorrhage": 95.99923570525895, "Cardiogenic shock": 3.040671287583894, "Cerebral haemorrhage": 7.171756197195853, "Chest discomfort": 9.460068622083837, "Chronic gastritis": 48.18818488575063, "Conjunctival haemorrhage": 10.210196166291176, "Coronary artery occlusion": 6.677786758875344, "Coronary artery stenosis": 15.183550255424525, "Diarrhoea haemorrhagic": 10.417887976840806, "Drug interaction": 4.957388398314164, "Duodenal ulcer": 15.889728071557718, "Duodenal ulcer haemorrhage": 32.86101281959504, "Dyspnoea": 4.729528355974472, "Dyspnoea at rest": 16.622340433961543, "Ecchymosis": 19.24954589386545, "Electrocardiogram ST segment elevation": 6.6434971709886135, "Epistaxis": 6.616247987252902, "Eye haemorrhage": 2.471622456330378, "Faeces discoloured": 16.77884091353526, "Gastric haemorrhage": 9.73669946209261, "Gastric mucosal lesion": 67.19114694267986, "Gastric ulcer": 7.536851715733031, "Gastric ulcer haemorrhage": 20.12180399203093, "Gastritis erosive": 18.44878041359304, "Gastrointestinal haemorrhage": 26.04518349788933, "Gingival bleeding": 14.890783877736542, "Gout": 5.717688853474336, "Haematemesis": 32.75609737472881, "Haematochezia": 17.488758055730678, "Haematoma": 3.075330957252272, "Haematuria": 9.169292620862317, "Haemoglobin decreased": 6.542218569003436, "Haemoptysis": 11.78474493545197, "Haemorrhage": 3.423993774908652, "Haemorrhage intracranial": 12.488215838481278, "Haemorrhage subcutaneous": 28.148778203318603, "Haemorrhage urinary tract": 13.819169447400435, "Haemorrhoidal haemorrhage": 10.6583566207891, "Haemothorax": 11.45930800695112, "Incorrect dose administered": 2.1559789812340373, "Iron deficiency anaemia": 4.468393646110373, "Labelled drug-drug interaction issue": 220.60996919041324, "Labelled drug-drug interaction medication error": 199.4374895009144, "Lower gastrointestinal haemorrhage": 62.99539964068568, "Melaena": 59.43068126127158, "Myopathy": 4.604628449945429, "Occult blood positive": 35.740598372901744, "Pericardial haemorrhage": 16.068820801386895, "Platelet aggregation inhibition": 471.91629779597486, "Post procedural haemorrhage": 5.864217060738054, "Product administration error": 3.396168971554871, "Product prescribing issue": 28.85639652403592, "Pulmonary alveolar haemorrhage": 14.28467889812784, "Pulmonary haemorrhage": 14.73140373657302, "Purpura": 2.5606403193661684, "Rectal haemorrhage": 4.633215208097326, "Respiratory rate increased": 6.941773923038289, "Respiratory tract haemorrhage": 38.35344174403821, "Rhabdomyolysis": 12.100416845817044, "Shock haemorrhagic": 8.554998460301464, "Sinus arrest": 44.90060240060416, "Subarachnoid haemorrhage": 11.808347174243016, "Subdural haematoma": 4.562433482018913, "Tachypnoea": 8.386228561773121, "Thrombotic thrombocytopenic purpura": 6.361380751466973, "Treatment noncompliance": 2.6151451612268586, "Upper gastrointestinal haemorrhage": 123.49584936936108, "Vascular stent thrombosis": 30.77366095198895, "Ventricular asystole": 129.26035004649873}
+{"amnesia": 74.44, "anxiety": 3.05, "chemical submission": 25053.41, "drug abuse": 89.15, "injection": 5888.55, "somnolence": 3.76, "vomiting": 2.21}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1086.json

@@ -1 +1 @@
-{"Acinetobacter infection": 277.80555008510726, "Acute respiratory distress syndrome": 22.522066524966064, "Bacteraemia": 36.34375560645968, "Blood bilirubin increased": 5.615273390056331, "Coagulopathy": 13.326420063187022, "Condition aggravated": 4.289461761704901, "Drug ineffective": 6.462126082232314, "Drug resistance": 27.68949377920479, "Electrocardiogram QT prolonged": 4.693007721334333, "Hepatic function abnormal": 6.801182166166319, "Klebsiella infection": 172.88050144707557, "Liver function test abnormal": 10.755994371264103, "Liver injury": 10.415109052940736, "Mental status changes": 13.007818977370368, "Off label use": 3.97389821027949, "Pancreatitis acute": 7.436616929245351, "Pathogen resistance": 136.24746640883976, "Platelet count decreased": 3.346382860616958, "Product use issue": 3.2657434304826096, "Pseudomembranous colitis": 41.874952011277145, "Sepsis": 4.944732210962315, "Septic shock": 8.127386617119294, "Thrombocytopenia": 2.779566695119553, "Tinnitus": 3.800741086353969}
+{"anaesthetic complication": 65.93, "anaesthetic complication neurological": 1559.17, "anaphylactic reaction": 12.87, "anaphylactic shock": 94.29, "anaphylactoid reaction": 11.08, "anaphylactoid shock": 167.66, "blood pressure decreased": 3.46, "bradycardia": 6.7, "bronchospasm": 53.69, "cardiac arrest": 12.16, "cardio-respiratory arrest": 10.26, "circulatory collapse": 11.83, "erythema": 4.85, "exposure during pregcy": 4.03, "horner's syndrome": 170.56, "hyperthermia maligt": 160.1, "hypotension": 15.17, "maternal exposure during delivery": 50.21, "maternal exposure during pregcy": 4.14, "oxygen saturation decreased": 3.88, "postoperative delirium": 1094.75, "rash maculo-papular": 3.51, "respiratory depression": 32.31, "shock": 14.04, "tachycardia": 5.14, "type i hypersensitivity": 33.11, "urticaria": 2.94, "withdrawal syndrome": 4.22}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1087.json

@@ -1 +1 @@
-{"Arrhythmia": 7.027505058064821, "Atrial fibrillation": 24.6926801367687, "Drug interaction": 5.800276807716031, "Electrocardiogram QT prolonged": 10.489360458467567, "Heart rate decreased": 14.197114362627648, "Heart rate increased": 6.239990256040112, "Visual impairment": 3.519889071561064}
+{"anaphylactic reaction": 54.61, "anaphylactic shock": 28.21, "bradycardia": 31.76, "bronchospasm": 54.3, "cardiac arrest": 25.11, "drug interaction": 7.19, "hypotension": 5.11, "off label use": 2.78, "recurrence of neuromuscular blockade": 2367.2}

docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1088.json

@@ -1 +1 @@
-{"Acute kidney injury": 6.690969155934481, "Acute lymphocytic leukaemia recurrent": 213.7602463923735, "Cytokine release syndrome": 372.884739585333, "Diffuse large B-cell lymphoma": 116.7143615763726, "Disease progression": 5.537481926080544, "Disseminated intravascular coagulation": 38.38684237003344, "Encephalopathy": 28.856036376113, "Febrile neutropenia": 13.811249080970205, "Haemophagocytic lymphohistiocytosis": 61.20934212873309, "Hypotension": 4.229431892781308, "Hypoxia": 17.688184690083133, "Immune effector cell-associated neurotoxicity syndrome": 378.3965970313274, "Lymphopenia": 75.03930993327171, "Malignant neoplasm progression": 2.229553208403124, "Neurotoxicity": 33.45867697076864, "Neutropenia": 3.2784398908442096, "Neutrophil count decreased": 22.27787845533811, "Platelet count decreased": 5.951540828268608, "Sepsis": 4.639928608539302, "Tumour lysis syndrome": 45.50688407212719, "White blood cell count decreased": 12.273883794568777}
+{"anaphylactic shock": 41.49}