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No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1918.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1918.json new file mode 100644 index 00000000000..ec9352039c1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1918.json @@ -0,0 +1 @@ +{"null": 3.839552982777063} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1919.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1919.json new file mode 100644 index 00000000000..02567f6ca69 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1919.json @@ -0,0 +1 @@ +{"null": 2.5460556445726743} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/192.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/192.json new file 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new file mode 100644 index 00000000000..757c13fdadc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1966.json @@ -0,0 +1 @@ +{"COMBIVIR": 54.60220120505437, "IBUPROFEN": 10.501102855375102, "KEPPRA": 5.150417628381677, "NEVIRAPINE": 97.95426256205126, "null": 3.823610935757082} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1967.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1967.json new file mode 100644 index 00000000000..0d6b33f1044 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1967.json @@ -0,0 +1 @@ +{"null": 4.843626274582155} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1968.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1968.json new file mode 100644 index 00000000000..8996e01e037 --- /dev/null +++ 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00000000000..8ff1279e31c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1979.json @@ -0,0 +1 @@ +{"null": 6.718693413790624} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/198.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/198.json new file mode 100644 index 00000000000..9c9c08214c0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/198.json @@ -0,0 +1 @@ +{"SIMPONI": 394.952495009093} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1980.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1980.json new file mode 100644 index 00000000000..a40f8eeeca2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1980.json @@ -0,0 +1 @@ +{"null": 6.142822436292995} \ No newline at end of file diff --git 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1988.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1988.json new file mode 100644 index 00000000000..dd81c4dc560 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1988.json @@ -0,0 +1 @@ +{"KALETRA": 83.80333773959204, "null": 2.091528472676385} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1989.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1989.json new file mode 100644 index 00000000000..e8c76b466bf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1989.json @@ -0,0 +1 @@ +{"null": 6.915373319994121} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/199.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/199.json new file mode 100644 index 00000000000..45bf45f1493 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/199.json @@ -0,0 +1 @@ +{"COMIRNATY": 1.7836035970150972} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1990.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1990.json new file mode 100644 index 00000000000..bb0f10b430d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1990.json @@ -0,0 +1 @@ +{"null": 1.7106632264816388} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1991.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1991.json new file mode 100644 index 00000000000..886199c8d75 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1991.json @@ -0,0 +1 @@ +{"null": 1.9021034470265756} \ No newline at end of file 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1994.json new file mode 100644 index 00000000000..3bb38c88f90 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1994.json @@ -0,0 +1 @@ +{"null": 5.924204865755229} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1995.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1995.json new file mode 100644 index 00000000000..a96fc79966b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1995.json @@ -0,0 +1 @@ +{"null": 4.745736607642976} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1996.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1996.json new file mode 100644 index 00000000000..980f60bd0c5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1996.json @@ -0,0 +1 @@ +{"null": 1.4013036081895904} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1997.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1997.json new file mode 100644 index 00000000000..d3fdc6b338d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1997.json @@ -0,0 +1 @@ +{"null": 4.960764579439824} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1998.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1998.json new file mode 100644 index 00000000000..77d82a819d8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1998.json @@ -0,0 +1 @@ +{"null": 2.951985109345318} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1999.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1999.json new file mode 100644 index 00000000000..04f83c0802b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/1999.json @@ -0,0 +1 @@ +{"null": 2.119843710264686} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2.json new file mode 100644 index 00000000000..931764198fa --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2.json @@ -0,0 +1 @@ +{"null": 14.313118104890432} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/20.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/20.json new file mode 100644 index 00000000000..6f9c3e0ed66 --- 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2001.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2001.json new file mode 100644 index 00000000000..d08e30f644f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2001.json @@ -0,0 +1 @@ +{"null": 4.855175014559221} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2002.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2002.json new file mode 100644 index 00000000000..05c7a2c781e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2002.json @@ -0,0 +1 @@ +{"ISENTRESS": 373.7811060545165, "null": 4.577231279559243} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2003.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2003.json new file mode 100644 index 00000000000..742356f565c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2003.json @@ -0,0 +1 @@ +{"null": 4.362431881502759} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2004.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2004.json new file mode 100644 index 00000000000..7ae6f0b7e0d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2004.json @@ -0,0 +1 @@ +{"null": 3.076441908714847} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2005.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2005.json new file mode 100644 index 00000000000..54cd560e674 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2005.json @@ -0,0 +1 @@ +{"APTIVUS": 547.0517563409115, "IBUPROFEN": 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2008.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2008.json new file mode 100644 index 00000000000..746d52629a4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2008.json @@ -0,0 +1 @@ +{"APTIVUS": 1140.4637512091592, "null": 3.161596924363436} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2009.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2009.json new file mode 100644 index 00000000000..7a9a620a044 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2009.json @@ -0,0 +1 @@ +{"null": 6.665797604505982} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/201.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/201.json new file mode 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--git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2012.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2012.json new file mode 100644 index 00000000000..6211486921e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2012.json @@ -0,0 +1 @@ +{"null": 9.529860179479076} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2013.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2013.json new file mode 100644 index 00000000000..744d799ea36 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2013.json @@ -0,0 +1 @@ +{"null": 2.848173647013041} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2014.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2014.json new file mode 100644 index 00000000000..975ec2af61f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2014.json @@ -0,0 +1 @@ +{"null": 6.423967744863229} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2015.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2015.json new file mode 100644 index 00000000000..79d92a4fc76 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2015.json @@ -0,0 +1 @@ +{"null": 1.3193243928001126} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2016.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2016.json new file mode 100644 index 00000000000..ecaf05a7d20 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2016.json @@ -0,0 +1 @@ +{"null": 10.133268100153286} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2017.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2017.json new file mode 100644 index 00000000000..cd30ce600d0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2017.json @@ -0,0 +1 @@ +{"null": 7.597558212164849} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2018.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2018.json new file mode 100644 index 00000000000..40a91348d92 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2018.json @@ -0,0 +1 @@ +{"null": 6.858535438694921} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2019.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2019.json new file mode 100644 index 00000000000..02b639386e9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2019.json @@ -0,0 +1 @@ +{"null": 3.87893833691815} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/202.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/202.json new file mode 100644 index 00000000000..22ab41b97d6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/202.json @@ -0,0 +1 @@ +{"COMIRNATY": 4.613036758058735} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2020.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2020.json new file mode 100644 index 00000000000..8cf864f6d6e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2020.json @@ -0,0 +1 @@ +{"null": 3.720001388026715} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2021.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2021.json new file mode 100644 index 00000000000..982c2c5ab22 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2021.json @@ -0,0 +1 @@ +{"null": 10.342615192874046} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2022.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2022.json new file mode 100644 index 00000000000..20d2848000f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2022.json @@ -0,0 +1 @@ +{"null": 2.226066968827946} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2023.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/2023.json new file mode 100644 index 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00000000000..5ee92000c5d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8540.json @@ -0,0 +1 @@ +{"COMIRNATY": 4.687358057553326} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8541.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8541.json new file mode 100644 index 00000000000..54148a98a27 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8541.json @@ -0,0 +1 @@ +{"COMIRNATY": 2.138038671763361, "GARDASIL": 8.801688959630235, "MMRVAXPRO": 19.86285678898617, "TOZINAMERAN": 2.622805498291795, "VAXZEVRIA": 2.0588415454860884} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8542.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8542.json new file mode 100644 index 00000000000..985dad91643 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8542.json @@ -0,0 +1 @@ +{"BEXSERO": 7.991036305563466, "COMIRNATY": 5.873642047094477, "COVID19": 1.0362127206551746, "INFANRIX": 4.47265674319959, "MENVEO": 47.43242298537725, "MMRVAXPRO": 6.734524941574374, "NIMENRIX": 8.988282594334297, "ROTATEQ": 1.6913601865666728, "SHINGRIX": 2.3788726115111585, "SPIKEVAX": 4.7061445608945, "VAXZEVRIA": 2.44147216210118} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8543.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8543.json new file mode 100644 index 00000000000..c0b26ebf1ff --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8543.json @@ -0,0 +1 @@ +{"COMIRNATY": 6.947657335236569, "COVID19": 2.3106827761968924, "ELASOMERAN": 2.883699324443119, "FENDRIX": 4.011770971260221, "FLUCELVAX": 3.617670764971858, "HEXYON": 1.6167098395528372, "MENVEO": 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end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8565.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8565.json new file mode 100644 index 00000000000..7c27c546dac --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8565.json @@ -0,0 +1 @@ +{"COVID19": 3.1231704019232844} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8566.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8566.json new file mode 100644 index 00000000000..ceda5f7b263 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/symptoms/8566.json @@ -0,0 +1 @@ +{"ADALIMUMAB": 11.706471024861564, "ALIGN": 164.720966623618, "AMINOSALICYLIC": 87.03466527243312, "AVAMYS": 45.67737894435127, "BUDESONIDE": 62.14163161807597, "ELLAONE": 95.53899126990868, "ESMYA": 13.615477879323098, "ISENTRESS": 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"Ventricular tachycardia ": 2.82057731676507, "Wheezing ": 13.498227550798324, "Wound haemorrhage ": 2.842972186660113} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1000.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1000.json new file mode 100644 index 00000000000..ffbba2d4422 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1000.json @@ -0,0 +1 @@ +{"Acromegaly ": 1167.8586757180838, "Arterial occlusive disease ": 61.40886252165932, "Blood cholesterol abnormal ": 125.68558345530217, "Blood growth hormone increased ": 1567.6136640463608, "Blood pressure increased ": 2.686796936401434, "Bradycardia ": 8.070583443582892, "Cellulitis ": 10.484020847367836, "Chest discomfort ": 3.042157678075463, "Drug hypersensitivity ": 6.223032204913022, "Drug intolerance ": 7.66977011149899, "Fall ": 2.486091072955514, "Gait disturbance ": 3.1426323205125577, "Goitre ": 97.82226335142823, "Heart rate decreased ": 15.84040714212818, "Hypersensitivity ": 4.052739252482582, "Inappropriate schedule of product administration ": 7.913379590326489, "Incorrect route of product administration ": 16.851669547281585, "Injection site bruising ": 42.68564604487056, "Injection site oedema ": 48.46273341790186, "Injection site pain ": 2.163059552454616, "Insulin-like growth factor increased ": 2152.5677485815067, "Limb injury ": 28.849978134739857, "Peripheral swelling ": 2.480743531082287, "Polyp ": 126.81002671235574, "Pulmonary embolism ": 5.5440660845432586, "Syringe issue ": 158.79809861795198, "Tendonitis ": 21.905398881491408, "Vital functions abnormal ": 721.8178136516517, "Weight decreased ": 2.1154762204860043, "Wound infection ": 82.84083206435105} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1001.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1001.json new file mode 100644 index 00000000000..5251693d2a7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1001.json @@ -0,0 +1 @@ +{"Intentional overdose ": 36.05160301566608} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1002.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1002.json new file mode 100644 index 00000000000..96de75b2383 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1002.json @@ -0,0 +1 @@ +{"Alpha 1 foetoprotein increased ": 117.58745308698218, "Ascites ": 5.550053398271658, "Blister ": 3.4120996548188627, "Diarrhoea ": 3.340768320133641, "Disease progression ": 5.839117538334553, "Drug ineffective for unapproved indication ": 6.258355117317848, "Erythema multiforme ": 5.510979238909851, "Haematotoxicity ": 11.741519357162655, "Hepatic encephalopathy ": 10.293247755647284, "Hepatic failure ": 6.0591430036270655, "Hepatocellular carcinoma ": 45.14421136202953, "Hepatotoxicity ": 5.478867204588851, "Hyperkeratosis ": 18.3733643542266, "Hypertension ": 3.0134384879071807, "Hypocalcaemia ": 9.6470695970997, "International normalised ratio increased ": 2.1038195462158686, "Malignant neoplasm progression ": 2.809789132493224, "Metastases to adrenals ": 69.905760963194, "Metastases to bone ": 8.459648334480317, "Metastases to liver ": 6.502514645388471, "Metastases to lung ": 30.543054872294285, "Metastatic renal cell carcinoma ": 30.86796027671447, "Mucosal inflammation ": 8.28979992726653, "Neoplasm progression ": 3.452534897166229, "Off label use ": 5.294186295744967, "Osteonecrosis of jaw ": 14.70981260897226, "Palmar-plantar erythrodysaesthesia syndrome ": 71.92652538146406, "Product use in unapproved indication ": 7.835608085660607, "Rash maculo-papular ": 2.776626436271433, "Renal cell carcinoma ": 15.910019249109528, "Skin exfoliation ": 2.8192660283382813, "Skin reaction ": 4.758319618050393, "Skin toxicity ": 49.06436858647975, "Skin ulcer ": 6.50701368486814, "Squamous cell carcinoma of skin ": 28.353003645537928, "Stevens-Johnson syndrome ": 4.156051349482739, "Thrombocytopenia ": 3.7812584689836473, "Tumour lysis syndrome ": 15.731632606322991, "Weight decreased ": 2.306152531961974} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1003.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1003.json new file mode 100644 index 00000000000..96d515a1766 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1003.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 10.805313105473848, "Aspartate aminotransferase increased ": 9.902324177422711, "Blood bilirubin increased ": 9.164748462552684, "Diarrhoea ": 5.963991070516686, "Disease progression ": 10.689063711986478, "Drug-induced liver injury ": 10.625814518937682, "Hepatic enzyme increased ": 5.34836961827246, "Hepatic function abnormal ": 9.268010685628123, "Hepatotoxicity ": 44.974335675532025, "Liver disorder ": 6.937692081216955, "Liver function test increased ": 17.2586945444678, "Lung adenocarcinoma ": 136.47393837646254, "Lung neoplasm malignant ": 12.518128619614066, "Non-small cell lung cancer ": 917.6710243441228, "Non-small cell lung cancer metastatic ": 2736.759079656651, "Off label use ": 2.092753891529357, "Therapy partial responder ": 73.56637711356981} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1004.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1004.json new file mode 100644 index 00000000000..c91498f9d19 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1004.json @@ -0,0 +1 @@ +{"Altered state of consciousness ": 2.024050394367631, "Ammonia increased ": 7.394131877404162, "Anaemia ": 8.55958588248953, "Ascites ": 9.094616982559542, "Atrial septal defect ": 6.304609474381127, "Autoimmune hepatitis ": 4.34647692809549, "Blood bilirubin increased ": 7.412695506256812, "Cerebral haemorrhage ": 2.4261612946622457, "Cerebral infarction ": 3.809744463535769, "Colitis ischaemic ": 5.542067546483547, "Death ": 2.0131114079317567, "Depression ": 2.201360839632474, "Disseminated intravascular coagulation ": 2.2543983797041407, "Drug ineffective ": 9.329143511706736, "Genotype drug resistance test positive ": 15.422815593871432, "Glomerular filtration rate decreased ": 4.504709760160125, "Haematemesis ": 3.071148194505439, "Haemoglobin decreased ": 8.082692589051026, "Haemolytic anaemia ": 12.313385417004216, "Hepatic cancer ": 14.629033122198743, "Hepatic cancer recurrent ": 602.0039890255414, "Hepatic cirrhosis ": 22.786745654044303, "Hepatic encephalopathy ": 28.74600624895768, "Hepatic failure ": 5.931417114939051, "Hepatic fibrosis ": 12.041285487330828, "Hepatitis ": 3.55365924842276, "Hepatitis B reactivation ": 24.750836315201404, "Hepatitis C ": 140.67988130454347, "Hepatitis C RNA increased ": 76.9606002229754, "Hepatitis C RNA positive ": 259.072465501785, "Hepatitis C virus test positive ": 55.05430937726681, "Hepatocellular carcinoma ": 48.2368636220552, "Hepatorenal syndrome ": 16.059846038349804, "Hyperbilirubinaemia ": 19.273544181611605, "Incorrect product administration duration ": 6.3377282494176175, "Infection reactivation ": 75.01193638089899, "Jaundice ": 7.378857502671108, "Loss of consciousness ": 2.441487455317065, "Lung neoplasm malignant ": 2.0633085005915626, "Lymphoma ": 6.231909913666382, "Mood swings ": 2.400183233757752, "Multiple organ dysfunction syndrome ": 2.8095887428918456, "Neoplasm malignant ": 2.3829166882263846, "Oedema peripheral ": 2.315672842128636, "Oesophageal varices haemorrhage ": 38.12947358924573, "Pancreatitis acute ": 2.857094945402418, "Photosensitivity reaction ": 2.332324622538988, "Portal vein thrombosis ": 15.421635932283817, "Product complaint ": 2.159330908377829, "Renal impairment ": 4.034343000103323, "Septic shock ": 3.187501681052547, "Spontaneous bacterial peritonitis ": 47.82313725936973, "Treatment failure ": 15.409961112093988, "Treatment noncompliance ": 3.1921722220004702, "Unevaluable event ": 2.45048167784442, "Upper gastrointestinal haemorrhage ": 2.09455964634024, "Viral load increased ": 23.913711484866848, "Virologic failure ": 24.4060372416836} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1005.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1005.json new file mode 100644 index 00000000000..57ef2b66fcc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1005.json @@ -0,0 +1 @@ +{"Pancreatitis acute ": 73.61796610087383} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1006.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1006.json new file mode 100644 index 00000000000..23c0dbb3bc6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1006.json @@ -0,0 +1 @@ +{"Abnormal menstrual clots ": 3.0774631601850557, "Adenovirus test ": 21.554777269242955, "Administration site erythema ": 2.0970263571297507, "Administration site lymphadenopathy ": 6.494326833387717, "Administration site movement impairment ": 3.3978104585021973, "Administration site pruritus ": 2.031268287377796, "Administration site rash ": 2.7611885244173955, "Administration site warmth ": 3.717820463072367, "Adnexa uteri pain ": 2.3914589139178872, "Alanine aminotransferase normal ": 35.163367348266625, "Allergy to vaccine ": 2.107029929152417, "Angiogram ": 2.000706393077717, "Angiogram pulmonary abnormal ": 30.57591402254277, "Anion gap ": 4.402474394814995, "Anticoagulant therapy ": 4.841745469737655, "Application site movement impairment ": 2.416036232546306, "Application site reaction ": 2.279170478242345, "Application site swelling ": 3.037670080509844, "Arthralgia ": 2.440285985882721, "Aspartate aminotransferase normal ": 28.635263974628977, "Axillary mass ": 3.713326017239901, "Axillary pain ": 4.556141088834684, "Bacille Calmette-Guerin scar reactivation ": 7.613017381293346, "Basophil percentage decreased ": 4.153048058998574, "Bell's palsy ": 2.73625648598697, "Blood alkaline phosphatase normal ": 39.35756489622921, "Blood bilirubin normal ": 52.301057913101545, "Blood calcium normal ": 19.006821888465364, "Blood chloride normal ": 36.95909529489059, "Blood creatinine normal ": 35.01662930204063, "Blood culture ": 11.423906227210628, "Blood culture negative ": 2.650084345537598, "Blood glucose normal ": 8.519953765621457, "Blood lactic acid ": 3.5993153147261423, "Blood potassium normal ": 46.0654465647587, "Blood sodium normal ": 37.80485096167001, "Blood test ": 13.544281500525624, "Blood test normal ": 27.38759860677889, "Blood urea normal ": 35.15792648551141, "Body temperature increased ": 2.7868887318038764, "Breakthrough COVID-19 ": 13.972936893647397, "Breast engorgement ": 2.0249198067576746, "COVID-19 immunisation ": 16.547311100504448, "COVID-19 pneumonia ": 2.2642297340864506, "Carbon dioxide normal ": 24.373665170271423, "Cardiac discomfort ": 3.5631494543020046, "Cardiac monitoring ": 3.4914295347383075, "Cardiac stress test ": 6.002965258409991, "Chest X-ray ": 20.15192392980808, "Chest X-ray normal ": 46.30816705880069, "Chills ": 3.94496462774514, "Computerised tomogram ": 24.183180943652648, "Computerised tomogram abdomen abnormal ": 8.962391645816457, "Computerised tomogram head ": 5.451270457966126, "Computerised tomogram head abnormal ": 8.634602311091168, "Computerised tomogram head normal ": 28.57885678946372, "Computerised tomogram normal ": 7.83115241830028, "Computerised tomogram thorax ": 6.532777321720162, "Computerised tomogram thorax abnormal ": 6.123801611806822, "Computerised tomogram thorax normal ": 28.635263974628977, "Delirium febrile ": 2.714958654070412, "Dermal filler reaction ": 8.075601187856439, "Diaphragmalgia ": 2.045932338497128, "Differential white blood cell count ": 28.283889350267376, "Dysmenorrhoea ": 2.465760366867761, "Ear inflammation ": 2.511613102518337, "Echocardiogram ": 18.47764831145529, "Echocardiogram abnormal ": 2.512676466444255, "Echocardiogram normal ": 22.650086034836544, "Ejection fraction normal ": 33.36303800782902, "Electrocardiogram ": 14.818124630254111, "Electrocardiogram normal ": 17.320045858299704, "Electroencephalogram ": 3.5556317021451456, "Erythema migrans ": 2.006440008413042, "Exercise tolerance decreased ": 2.072699732365172, "Exposure to SARS-CoV-2 ": 4.5752358474877886, "Extensive swelling of vaccinated limb ": 11.76699274190488, "Eye infarction ": 2.621690883762172, "Facial discomfort ": 2.0402698263044114, "Fatigue ": 2.715820605658442, "Feeling hot ": 3.1717920327818945, "Fibrin D dimer ": 12.58163461267607, "Full blood count ": 12.740736311781546, "Full blood count normal ": 9.196383097252456, "Glomerular filtration rate normal ": 16.29216072354908, "Growing pains ": 3.138813132716742, "Haematocrit normal ": 20.527430928801905, "Haemoglobin normal ": 17.038389992662317, "Headache ": 2.5881114100736435, "Heart rate ": 2.476791207621503, "Heavy menstrual bleeding ": 2.476769605779709, "Hypomenorrhoea ": 2.151072070477509, "Immediate post-injection reaction ": 10.158963537880574, "Immunisation reaction ": 4.877326270163718, "Immunoglobulin therapy ": 4.260687219835851, "Impaired work ability ": 2.01232923308311, "Influenza ": 3.345594059956712, "Influenza A virus test negative ": 28.879922193631675, "Influenza B virus test ": 27.96292819423499, "Influenza like illness ": 2.058936877873601, "Influenza virus test negative ": 10.471255506495, "Injected limb mobility decreased ": 4.654410079293224, "Injection site discomfort ": 3.050744018309254, "Injection site erythema ": 8.616017183577258, "Injection site haematoma ": 4.845505468415294, "Injection site hypersensitivity ": 2.7052043189146726, "Injection site hypoaesthesia ": 2.269605912220934, "Injection site induration ": 8.571263013660637, "Injection site inflammation ": 10.07762846519463, "Injection site joint movement impairment ": 2.9882110432863307, "Injection site lymphadenopathy ": 3.386726191867222, "Injection site macule ": 2.2311628493172946, "Injection site movement impairment ": 4.564479292133886, "Injection site muscle weakness ": 2.8505726202188577, "Injection site oedema ": 2.069742848874513, "Injection site pain ": 5.90173206900908, "Injection site paraesthesia ": 2.5540565169392084, "Injection site pruritus ": 9.135957619599882, "Injection site rash ": 2.983290176891367, "Injection site reaction ": 4.064794001536034, "Injection site swelling ": 9.323067276692438, "Injection site warmth ": 11.3519024947709, "Inner ear inflammation ": 2.313142173174804, "Intensive care ": 3.4645391636429013, "Interchange of vaccine products ": 2.5343236687583945, "Intermenstrual bleeding ": 2.435020914600985, "Itching scar ": 2.00187227119521, "Laboratory test ": 34.9703162556709, "Laboratory test normal ": 12.24010533147733, "Limb discomfort ": 4.774105907953095, "Local reaction ": 3.344580535381688, "Lymph node pain ": 3.15479936222887, "Lymphadenopathy ": 3.74661948790408, "Magnetic resonance imaging ": 16.14723547511517, "Magnetic resonance imaging head ": 3.9302928745301777, "Magnetic resonance imaging head normal ": 15.60778192516601, "Magnetic resonance imaging heart ": 6.649218182807665, "Magnetic resonance imaging normal ": 11.364666689149423, "Malaise ": 3.146917849081165, "Maternal exposure during breast feeding ": 2.548655073136345, "Mechanical urticaria ": 9.034999274725912, "Menometrorrhagia ": 2.391940829647871, "Menstrual cycle management ": 2.4609535884259084, "Menstrual discomfort ": 2.68963012723821, "Menstrual disorder ": 2.794989298768743, "Menstruation delayed ": 2.151318453640999, "Menstruation irregular ": 2.682871572706525, "Metabolic function test ": 38.15829329414724, "Metabolic function test normal ": 11.364666689149423, "Multisystem inflammatory syndrome ": 2.158726640069617, "Multisystem inflammatory syndrome in adults ": 2.571117724806057, "Muscle swelling ": 2.872749278880861, "Myalgia ": 3.479196381544742, "Myelin oligodendrocyte glycoprotein antibody-associated disease ": 2.5794529249278506, "Myocarditis ": 3.287676577148453, "Myopericarditis ": 4.962108452054618, "Nasal herpes ": 2.502915692613385, "Neuralgic amyotrophy ": 2.995391023354006, "New daily persistent headache ": 3.4537518657525337, "Oligomenorrhoea ": 2.5452551465113684, "Ovulation pain ": 2.47919315784784, "Pain in extremity ": 2.219818141371047, "Painful respiration ": 2.29159335936884, "Platelet count normal ": 13.620252842493365, "Polymenorrhoea ": 2.8110501066686715, "Positive airway pressure therapy ": 4.225397257192262, "Post vaccination syndrome ": 2.5608776459681635, "Post-acute COVID-19 syndrome ": 2.245101233871936, "Postmenopausal haemorrhage ": 2.570973484005285, "Premenstrual pain ": 2.583839208313918, "Premenstrual syndrome ": 2.114200739273832, "Presyncope ": 2.5206626242489656, "Procalcitonin ": 19.325597411746887, "Pulmonary pain ": 2.231196819630564, "Puncture site erythema ": 2.9954461370993446, "Puncture site oedema ": 2.2103855848006937, "Puncture site pain ": 2.131367919443887, "Puncture site pruritus ": 2.712860085117506, "Puncture site reaction ": 4.278361561000895, "Puncture site swelling ": 2.334604192650971, "Pyrexia ": 2.677475144843428, "Respiratory syncytial virus test negative ": 7.866421370963003, "Rest regimen ": 3.204546507841324, "SARS-CoV-2 antibody test negative ": 2.1231405514654367, "SARS-CoV-2 test ": 2.6901574532595385, "SARS-CoV-2 test positive ": 2.915732353420042, "Scan with contrast abnormal ": 13.10763368182544, "Shoulder injury related to vaccine administration ": 2.004488703120628, "Sick leave ": 3.492837131445471, "Skin warm ": 2.1447636384831417, "Specialist consultation ": 2.011614554980645, "Tenderness ": 2.4151363067476264, "Thrombectomy ": 2.1051000148635497, "Thyroiditis subacute ": 2.0226912975854536, "Tinnitus ": 2.052292351488166, "Trichodynia ": 2.712860085117506, "Troponin ": 9.75811868638285, "Troponin I ": 5.679679993878258, "Troponin normal ": 40.46109610907418, "Ultrasound Doppler ": 9.24490278161382, "Ultrasound Doppler abnormal ": 5.154628377720705, "Ultrasound scan ": 18.04575208717693, "Urine analysis ": 21.33904342330189, "Urine analysis normal ": 9.96885882609656, "Urticaria chronic ": 6.508354758827746, "Urticaria physical ": 3.776076810247838, "Uterine pain ": 2.156346582957462, "Vaccination complication ": 2.737371319048978, "Vaccination site anaesthesia ": 3.402988927522148, "Vaccination site bruising ": 2.9132756661457933, "Vaccination site dermatitis ": 2.478082636637355, "Vaccination site discharge ": 2.847796623496854, "Vaccination site discolouration ": 3.847075015678275, "Vaccination site discomfort ": 3.5853665329324613, "Vaccination site dysaesthesia ": 3.110252584768116, "Vaccination site eczema ": 2.163961480796769, "Vaccination site erythema ": 9.50183620078729, "Vaccination site exfoliation ": 3.776076810247838, "Vaccination site haematoma ": 2.303944388374126, "Vaccination site haemorrhage ": 2.489998353472764, "Vaccination site hyperaesthesia ": 5.359740093047969, "Vaccination site hypersensitivity ": 3.1837434837406797, "Vaccination site induration ": 4.373666528166975, "Vaccination site infection ": 5.815067105576863, "Vaccination site inflammation ": 4.0641514444245015, "Vaccination site irritation ": 4.449396973750255, "Vaccination site joint erythema ": 5.072045065794659, "Vaccination site joint movement impairment ": 2.9523222063154257, "Vaccination site joint pain ": 2.899476044892268, "Vaccination site joint swelling ": 5.149752862700527, "Vaccination site joint warmth ": 4.295542955474835, "Vaccination site lymphadenopathy ": 4.465612296887367, "Vaccination site macule ": 14.535878247339587, "Vaccination site mass ": 2.2159526604587776, "Vaccination site movement impairment ": 5.594706912012897, "Vaccination site oedema ": 4.7061445608945, "Vaccination site pain ": 3.6096616179270713, "Vaccination site papule ": 2.3307675183328644, "Vaccination site paraesthesia ": 2.19987097405362, "Vaccination site plaque ": 16.638904428226112, "Vaccination site pruritus ": 9.211307139784228, "Vaccination site pustule ": 3.384164207232451, "Vaccination site rash ": 12.846320600044182, "Vaccination site reaction ": 8.15299973998501, "Vaccination site swelling ": 7.094089261821529, "Vaccination site urticaria ": 9.8804098336149, "Vaccination site vesicles ": 2.284806062540618, "Vaccination site warmth ": 8.898443574370981, "Vaccine breakthrough infection ": 14.240635620540903, "Vaccine positive rechallenge ": 4.045565735356236, "Weight bearing difficulty ": 3.024007100320395, "White blood cell count normal ": 30.033412621196096, "X-ray ": 21.33904342330189} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1007.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1007.json new file mode 100644 index 00000000000..5f331a494a0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1007.json @@ -0,0 +1 @@ +{"Activated partial thromboplastin time prolonged ": 5.483916253970602, "Acute respiratory failure ": 16.77516946998773, "Adenovirus infection ": 11.536564054113493, "Ankle fracture ": 2.7369788983894483, "Apnoea ": 8.790394260314505, "Appendicitis ": 2.5298747996263806, "Arachnoiditis ": 96.45144110812238, "Aspiration ": 33.10227313430038, "Atelectasis ": 33.12181758665838, "Autism spectrum disorder ": 5.350631067002635, "Back pain ": 3.958708126764131, "Bacteraemia ": 3.8972613411075407, "Brain death ": 11.070390026079266, "Brain injury ": 8.162099182819983, "Bronchial secretion retention ": 60.50588926688396, "Bronchiolitis ": 21.283858879245017, "Bronchitis ": 3.549074768555447, "COVID-19 pneumonia ": 3.458310336004075, "CSF pressure increased ": 767.8668887336981, "CSF protein increased ": 130.96199138448975, "CSF test abnormal ": 61.07861641853554, "Cardiac arrest ": 4.748934470221276, "Cardio-respiratory arrest ": 7.501035723460521, "Cerebrospinal fluid leakage ": 177.95860879228582, "Choking ": 6.074218162951523, "Chronic respiratory failure ": 83.49504945234207, "Clostridium difficile infection ": 2.439469699591208, "Death ": 2.7638602143759345, "Dehydration ": 2.5487356148541225, "Device dislocation ": 22.001517168446597, "Device related infection ": 4.573279179665016, "Dysphagia ": 3.8667067467362215, "Enterovirus infection ": 171.5457392307427, "Faecaloma ": 6.859016139206288, "Femur fracture ": 16.382098824429015, "Foot fracture ": 2.061476419417024, "Gait inability ": 6.485456111872511, "Gastroenteritis ": 3.977676834297863, "Gastroenteritis viral ": 8.37322402749472, "Gastrointestinal infection ": 18.743216724599115, "Hip fracture ": 4.253945306229179, "Hydrocephalus ": 37.80372092143507, "Hyperthermia ": 2.1185299658147625, "Hypotonia ": 2.3214445971719915, "Hypoxia ": 2.6077343636746, "Increased appetite ": 2.183575142400596, "Increased bronchial secretion ": 32.878367472672025, "Infection ": 3.2193352830439386, "Intracranial pressure increased ": 24.771798699238182, "Joint dislocation ": 19.576110150056387, "Kyphosis ": 19.4294991677899, "Lower limb fracture ": 6.242113081147199, "Malnutrition ": 15.777376221445708, "Mechanical ventilation complication ": 111.4787948553636, "Meningitis ": 10.622511670869004, "Meningitis aseptic ": 15.887930131253365, "Meningitis bacterial ": 40.26448965100187, "Meningitis chemical ": 162.41417442634565, "Metapneumovirus infection ": 58.59525912964613, "Mobility decreased ": 2.969403561972793, "Motor dysfunction ": 19.01756437435784, "Muscle contracture ": 22.321433396426976, "Muscle tightness ": 3.501321337847505, "Muscular weakness ": 2.584331345227675, "Nasopharyngitis ": 2.170590741597012, "Nephrolithiasis ": 5.845623521259975, "Neurological examination abnormal ": 194.5464689476435, "Neurological procedural complication ": 1658.1405853221372, "Oxygen saturation decreased ": 5.296742676414011, "Parainfluenzae virus infection ": 51.23897082039803, "Physical examination abnormal ": 263.044119806319, "Pleocytosis ": 61.1953986922888, "Pneumonia ": 7.763580444698442, "Pneumonia aspiration ": 7.300812164484346, "Pneumonia bacterial ": 5.863496938056331, "Pneumonia respiratory syncytial viral ": 60.99532952499428, "Pneumonia viral ": 25.57541487592364, "Pneumothorax ": 11.107134247403348, "Polyuria ": 2.795973211520785, "Post lumbar puncture syndrome ": 6081.1811400013785, "Post procedural complication ": 57.565698813811885, "Post procedural fever ": 204.8236967187005, "Post procedural haematoma ": 19.88214714778649, "Post procedural haemorrhage ": 7.181089276620807, "Post procedural infection ": 23.51661666310653, "Post procedural swelling ": 107.72222377474203, "Prescribed underdose ": 7.158483424727773, "Procedural anxiety ": 278.9977731143591, "Procedural complication ": 72.53106069592043, "Procedural headache ": 469.6356570752501, "Procedural nausea ": 191.43637376659936, "Procedural pain ": 120.87952076780572, "Procedural vomiting ": 231.11594451421843, "Protein total increased ": 13.204125319543, "Protein urine present ": 10.162907183565522, "Proteinuria ": 7.17713036823594, "Pseudomonas infection ": 8.923477398241392, "Radicular pain ": 83.89137901624666, "Renal tubular acidosis ": 16.411660718642572, "Respiratory arrest ": 8.090625846430132, "Respiratory disorder ": 19.68683494139902, "Respiratory distress ": 7.306733321550579, "Respiratory failure ": 9.519971672657489, "Respiratory syncytial virus infection ": 45.103951379338014, "Respiratory tract infection ": 31.54222771694424, "Respiratory tract infection viral ": 47.9386322924686, "Respiratory tract procedural complication ": 1034.927608000197, "Rhinovirus infection ": 215.56437940435765, "Road traffic accident ": 2.320446465359991, "SARS-CoV-2 test positive ": 4.789618612811015, "Salivary hypersecretion ": 5.2650368230409965, "Sciatica ": 2.935158369290608, "Scoliosis ": 396.9027946407125, "Secretion discharge ": 6.885173133584046, "Sepsis ": 3.006695459368724, "Sinus tachycardia ": 2.5668289144229326, "Spinal deformity ": 69.51131926309743, "Spinal disorder ": 9.500529832406912, "Spinal fusion surgery ": 18.415399745440105, "Spinal implantation ": 859.3049643898396, "Spinal muscular atrophy ": 3483.2606846503195, "Spinal pain ": 3.7459468304097903, "Sudden death ": 4.056151798283298, "Therapeutic product effect decreased ": 2.681196153624524, "Therapeutic response shortened ": 12.41470003414732, "Tibia fracture ": 13.395104867026284, "Tracheostomy ": 23.75630104692188, "Tracheostomy malfunction ": 263.044119806319, "Traumatic lumbar puncture ": 2547.739059467472, "Upper respiratory tract infection ": 5.099917008781794, "Viral infection ": 13.003892029886169, "Viral upper respiratory tract infection ": 18.891870948840715, "Vital capacity decreased ": 66.0556316173409, "Weight gain poor ": 31.273888111899563} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1008.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1008.json new file mode 100644 index 00000000000..e975b75de48 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1008.json @@ -0,0 +1 @@ +{"Acute generalised exanthematous pustulosis ": 11.07671652950718, "Acute kidney injury ": 8.422207320297622, "Aortic valve incompetence ": 11.268573145889905, "Ascites ": 2.1136240177036707, "Asthenia ": 3.9685167624373614, "Atrial fibrillation ": 2.971471402157264, "Atrioventricular block first degree ": 35.292927625036306, "Blood bicarbonate decreased ": 18.995486497641668, "Blood creatinine increased ": 4.861131845862096, "Blood potassium decreased ": 6.039902749214058, "Blood potassium increased ": 16.094187136185464, "Blood urea increased ": 7.348090767427529, "Bradycardia ": 4.588331015162281, "Bradykinesia ": 10.966886660036874, "Bundle branch block left ": 23.01533555110131, "Cardiac amyloidosis ": 112.6449002631122, "Cardiac failure ": 3.636681709964913, "Cardiac failure acute ": 7.21211825262986, "Cardiac failure chronic ": 15.220407114938345, "Cardioactive drug level increased ": 11.764740399343404, "Cardiomegaly ": 4.053404230326045, "Coagulopathy ": 4.447403936477113, "Cognitive disorder ": 3.055447068404584, "Coronary artery disease ": 2.121879978125937, "Dehydration ": 4.63280570699531, "Dementia ": 5.34560661643054, "Drug interaction ": 3.2508871332603007, "Drug reaction with eosinophilia and systemic symptoms ": 6.40340977636457, "Dyspnoea at rest ": 14.069321519260678, "Dysuria ": 3.1585164248025936, "Electrocardiogram QRS complex prolonged ": 22.613720660769097, "Electrocardiogram QT prolonged ": 2.033134358926629, "Electrocardiogram T wave peaked ": 125.96764329885842, "Electrocardiogram abnormal ": 6.0407738948376, "Electrolyte imbalance ": 4.82379326386435, "Exercise tolerance decreased ": 3.2848676507240726, "Fall ": 2.822373179836537, "Fluid retention ": 2.71226278834474, "Gastric polyps ": 23.037116044823573, "Glomerular filtration rate decreased ": 3.442983425662264, "Gynaecomastia ": 15.522617916415909, "Haematuria ": 2.502485500229438, "Heart failure with reduced ejection fraction ": 91.6620794935685, "Hiatus hernia ": 9.265685885806302, "Hyperkalaemia ": 53.296380247026285, "Hypokalaemia ": 4.438349673040297, "Hyponatraemia ": 10.753680909294111, "Hypophagia ": 4.001368138956946, "Hypotension ": 5.585144448530038, "Hypovolaemia ": 15.800302349654713, "Left ventricular dysfunction ": 7.442164055802391, "Medication error ": 3.736153846002881, "Metabolic acidosis ": 8.104403705802996, "Mitral valve incompetence ": 6.882078331051297, "Mobility decreased ": 2.240356063463286, "Motor dysfunction ": 9.763492882981032, "Multiple organ dysfunction syndrome ": 2.989912938021328, "Muscular weakness ": 2.534329561959896, "Neuroglycopenia ": 249.3962780602105, "Obstructive pancreatitis ": 53.42267375952956, "Oedema peripheral ": 3.818025650372767, "Oliguria ": 5.320506039465583, "Orthostatic hypotension ": 11.7506807097621, "Parkinsonism ": 9.596792245219186, "Premature delivery ": 3.490646309951432, "Product prescribing error ": 2.582734282324931, "Pulmonary congestion ": 5.505601221742188, "Pulmonary oedema ": 2.293647973691361, "Rales ": 6.71961083711728, "Renal impairment ": 2.7059326491478504, "Sedation ": 2.2512968587409645, "Sinus bradycardia ": 9.203078730037015, "Stevens-Johnson syndrome ": 12.230220316617617, "Tachypnoea ": 2.356091645541289, "Toxic epidermal necrolysis ": 2.25807257142071, "Transplant dysfunction ": 57.08350101015496, "Type 2 diabetes mellitus ": 2.373816391411525, "Urine output decreased ": 5.19943416198889, "Ventricular extrasystoles ": 3.746539828197271, "Ventricular tachycardia ": 5.605748626842942} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1009.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1009.json new file mode 100644 index 00000000000..3f56083d058 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1009.json @@ -0,0 +1 @@ +{"Acne ": 2.8943809398626428, "Acute febrile neutrophilic dermatosis ": 6.634634804836901, "Acute lymphocytic leukaemia recurrent ": 16.003557433818624, "Acute pulmonary oedema ": 4.703200832599902, "Adverse event ": 11.495086735934722, "Anaemia ": 2.384579389336615, "Ascites ": 2.692870506318313, "Aspiration pleural cavity ": 197.14187567627616, "Atrial fibrillation ": 2.229927328934941, "Back disorder ": 2.2719091286628488, "Blast cell crisis ": 109.22375482219668, "Blast cell proliferation ": 220.94495881242807, "Blast crisis in myelogenous leukaemia ": 48.87093153735267, "Blood disorder ": 5.0115704348312615, "Bone marrow disorder ": 24.01807590942227, "Bone marrow failure ": 4.066230714832817, "Bone marrow transplant ": 57.5797450471399, "Bone pain ": 2.4044314156253144, "Cardiac disorder ": 2.8237789212132216, "Cardiac failure ": 4.0948822638290805, "Cardiac failure congestive ": 4.369320382554774, "Cardiomegaly ": 2.342140589692949, "Cellulitis ": 2.11163914374498, "Chronic myeloid leukaemia ": 31.67543986635461, "Chronic myeloid leukaemia recurrent ": 67.695276543408, "Chronic myeloid leukaemia transformation ": 63.33824132155883, "Chylothorax ": 246.4346928007508, "Clostridium difficile infection ": 2.302652651206349, "Colitis ": 5.147579309064161, "Cytomegalovirus colitis ": 7.747378279755652, "Cytomegalovirus enterocolitis ": 20.096597514153, "Cytopenia ": 14.195674988659032, "Death ": 3.0955379074819898, "Dialysis ": 2.0407428764158344, "Drug resistance ": 2.3768187423880542, "Dyspnoea exertional ": 2.163196769848902, "Electrocardiogram QT prolonged ": 3.005192238850612, "Enterocolitis ": 4.007591691421756, "Enterocolitis haemorrhagic ": 17.94287258450815, "Eye haemorrhage ": 2.001490514118895, "Fluid retention ": 13.009506275855774, "Full blood count decreased ": 12.560052394155456, "Gallbladder disorder ": 2.766935122549561, "Gastrointestinal haemorrhage ": 3.3973685983653867, "Gastrointestinal infection ": 3.700380359652028, "Gene mutation ": 30.13713785139111, "Generalised oedema ": 3.022556364643147, "Graft versus host disease ": 4.342558962680672, "Haematochezia ": 2.25613447702314, "Haematotoxicity ": 4.18291779009479, "Haemorrhage ": 2.173939979543705, "Haemothorax ": 9.280297829664793, "Hospitalisation ": 12.146825424779822, "Intentional product use issue ": 4.0174721438645, "Internal haemorrhage ": 4.193435703955299, "Intestinal haemorrhage ": 2.6777595367461493, "Iron deficiency anaemia ": 2.633098621141812, "Leukaemia ": 9.611546395556612, "Leukaemia recurrent ": 11.621405669090858, "Lower gastrointestinal haemorrhage ": 3.111106895934293, "Lung disorder ": 2.0766461174880537, "Lung infiltration ": 4.648382745863988, "Lymphocytosis ": 10.32387784063538, "Malignant neoplasm progression ": 11.37571149675828, "Nephrotic syndrome ": 4.129193005343136, "Neuropathy peripheral ": 2.753664306520925, "Oedema ": 2.8288642460091658, "Pancytopenia ": 5.441121560058406, "Pericardial effusion ": 37.59568427821048, "Peripheral arterial occlusive disease ": 5.747034098392515, "Philadelphia chromosome positive ": 192.5274851188784, "Platelet count decreased ": 2.82738743825597, "Platelet count increased ": 3.0776449567349133, "Platelet transfusion ": 16.00890211337492, "Pleural effusion ": 109.2133794519122, "Pleurisy ": 14.555241378223528, "Pneumonia ": 3.621915036173572, "Pneumonia fungal ": 4.469600005136266, "Prescribed underdose ": 52.94852112096044, "Pulmonary alveolar haemorrhage ": 2.164208839156093, "Pulmonary arterial hypertension ": 29.84099635259896, "Pulmonary congestion ": 2.0745240644969254, "Pulmonary hypertension ": 36.73884058237484, "Pulmonary oedema ": 35.82384011054767, "Rectal cancer ": 5.159626074196619, "Red blood cell count decreased ": 3.0586655438707, "Respiratory tract congestion ": 3.683894496107481, "Retinal haemorrhage ": 2.576803306524529, "Right ventricular failure ": 3.663126823974151, "Splenomegaly ": 4.41534119793763, "Stem cell transplant ": 26.569155703680966, "Subdural haematoma ": 3.095648272598268, "Therapeutic response decreased ": 4.488711423594883, "Therapy non-responder ": 4.272067117253211, "Thrombocytopenia ": 3.4909548383879643, "Transfusion ": 8.59006720776718, "Transplant ": 8.928009173052821, "Tumour lysis syndrome ": 3.2651310485254226, "White blood cell count abnormal ": 3.2217981393792985, "White blood cell count increased ": 3.625381617941589} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/101.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/101.json new file mode 100644 index 00000000000..217aa395fb5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/101.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 3.432034511827625, "Abdominal distension ": 3.0218247559599405, "Adjustment disorder with depressed mood ": 113.06969794229198, "Adverse drug reaction ": 21.84387452660102, "Adverse reaction ": 12.46491837827897, "Alanine aminotransferase increased ": 2.3560331402429986, "Alopecia ": 4.916715467900437, "Amnesia ": 11.50680238375522, "Anti-cyclic citrullinated peptide antibody positive ": 33.096166370714364, "Arthropathy ": 12.876044526087918, "Aspartate aminotransferase increased ": 2.6935852788759296, "Autoimmune disorder ": 17.645462022278814, "Back injury ": 18.11018938569901, "Basal cell carcinoma ": 21.484128842708625, "Blepharospasm ": 59.4378117934347, "Blood cholesterol increased ": 21.31229026981577, "Blood parathyroid hormone decreased ": 77.84293364138503, "Breast cancer stage III ": 18.235486175493147, "Bursitis ": 16.22235912199517, "C-reactive protein ": 58.05933439558506, "C-reactive protein abnormal ": 21.789986044552595, "C-reactive protein increased ": 13.370135687516507, "Coeliac disease ": 15.557613018461916, "Condition aggravated ": 2.8278864145491256, "Confusional state ": 2.6737909583585724, "Contraindicated product administered ": 15.695889562123552, "Cytokine storm ": 66.60349547674689, "Decreased appetite ": 2.591977508052677, "Deep vein thrombosis postoperative ": 8.384900697958118, "Delirium ": 15.28440478114908, "Disability ": 3.594502714886528, "Discomfort ": 9.890262784334508, "Dislocation of vertebra ": 221.507324583466, "Disseminated intravascular coagulation ": 3.682433240215802, "Drug eruption ": 5.853536931596886, "Drug hypersensitivity ": 11.75709119040272, "Drug intolerance ": 5.091118304412586, "Drug tolerance decreased ": 27.00138262471977, "Drug-induced liver injury ": 4.86332378173412, "Dry mouth ": 3.4830221569089703, "Duodenal ulcer perforation ": 23.935253822625956, "Dyspepsia ": 3.7391949386541614, "Enthesopathy ": 96.69622785994478, "Epilepsy ": 10.010226227238338, "Facet joint syndrome ": 44.73696129518514, "Fibromyalgia ": 12.549137230118596, "Finger deformity ": 24.512138915914203, "Folliculitis ": 13.266354768790489, "Gait disturbance ": 4.878979213777744, "Gait inability ": 7.760141213654442, "Gastrointestinal disorder ": 3.0133072435261083, "Gastrooesophageal reflux disease ": 6.037412219410965, "General physical health deterioration ": 5.652607483802892, "Glossodynia ": 5.044314927048245, "Granuloma skin ": 113.51445573635232, "Grip strength decreased ": 93.42765945488998, "Hand deformity ": 13.597033352859649, "Helicobacter infection ": 14.214965474978568, "Hepatic enzyme increased ": 6.670186334260973, "Hip arthroplasty ": 19.70174355969116, "Hypercalcaemia ": 16.766447692907377, "Hypercholesterolaemia ": 3.1427390531804567, "Hypersensitivity ": 3.161166247713074, "Hypoaesthesia ": 3.4200725946268364, "Incorrect route of product administration ": 4.563710557295238, "Inflammation ": 6.198283395343084, "Infusion related reaction ": 13.742923219633482, "Injury ": 10.427894900771989, "Iron deficiency ": 16.683504571789697, "Joint swelling ": 5.527664314302268, "Knee arthroplasty ": 18.174431140073462, "Lip dry ": 7.089402273940031, "Live birth ": 28.497321730821493, "Liver injury ": 5.634168981451155, "Loss of personal independence in daily activities ": 2.978394408819015, "Lower limb fracture ": 16.03664259157772, "Maternal exposure during pregnancy ": 2.6306432381254594, "Memory impairment ": 3.471302949247177, "Migraine ": 2.620634789629685, "Mobility decreased ": 12.221507413573692, "Muscle injury ": 21.68880441626898, "Muscular weakness ": 3.1031281553987, "Musculoskeletal pain ": 9.06383803522002, "Musculoskeletal stiffness ": 10.823090623686443, "Night sweats ": 2.2905177900150364, "Obesity ": 6.346264408954157, "Osteoarthritis ": 2.873053991334549, "Panniculitis ": 53.17751302090653, "Pemphigus ": 2.069948935221054, "Pericarditis ": 5.153502246351762, "Peripheral swelling ": 3.2941311668734694, "Peripheral venous disease ": 21.312116555646824, "Prescribed overdose ": 3.014320009463184, "Product quality issue ": 10.715493763558364, "Product use in unapproved indication ": 2.838507746192976, "Product use issue ": 2.3079170981950936, "Psoriatic arthropathy ": 25.479445587990757, "Rash pruritic ": 2.1632925714268985, "Red blood cell sedimentation rate ": 447.2689026325131, "Red blood cell sedimentation rate abnormal ": 5.828459560207387, "Red blood cell sedimentation rate increased ": 6.650550715651783, "Retroperitoneal haematoma ": 19.220423831318243, "Rheumatic fever ": 156.28610650017237, "Rheumatoid arthritis ": 7.7303399343699954, "Rheumatoid factor positive ": 69.50122848091762, "Sciatica ": 6.610966849558594, "Septic shock ": 2.0968844127904083, "Shock haemorrhagic ": 6.352401593648557, "Skin abrasion ": 4.924091944392407, "Sleep disorder ": 5.225999522163675, "Sleep disorder due to general medical condition, insomnia type ": 11.305619946130903, "Swelling ": 2.01257633174931, "Swollen joint count increased ": 130.637047524376, "Synovitis ": 4.9177431661289726, "Systemic lupus erythematosus ": 2.329742859258386, "Taste disorder ": 7.716361181389326, "Therapeutic product effect decreased ": 10.591935002520287, "Treatment failure ": 6.552691013964545, "Weight decreased ": 2.161337933005101, "Wound ": 2.428873212538081} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1010.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1010.json new file mode 100644 index 00000000000..55d92ddd42e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1010.json @@ -0,0 +1 @@ +{"Completed suicide ": 53.30328829485575, "Drug interaction ": 16.656255131491992} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1011.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1011.json new file mode 100644 index 00000000000..6fce224f0ba --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1011.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 3.405736030382148, "Abnormal dreams ": 2.702998184368318, "Aggression ": 4.866415552809968, "Agitation ": 3.947008318390966, "Akinesia ": 60.21426549310371, "Apathy ": 2.131198435493688, "Aspiration ": 4.96983879617291, "Behaviour disorder ": 3.3670274828395783, "Choking ": 5.741959648652567, "Chromaturia ": 20.417729351749163, "Colitis microscopic ": 29.750259077171357, "Confusional state ": 4.2149965511639325, "Coordination 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prescribing error ": 4.978415313901908, "Product quality issue ": 2.3635455221260697, "Product residue present ": 10.629254931708047, "Product size issue ": 27.248367343819105, "Product supply issue ": 35.574906451178286, "Product use complaint ": 12.432151262976552, "Psychomotor hyperactivity ": 11.440689702563777, "Psychotic disorder ": 4.340717643291604, "Rhabdomyolysis ": 2.870390291627024, "Salivary hypersecretion ": 5.172281028187067, "Serotonin syndrome ": 2.6394945306584607, "Somnolence ": 2.161071015318711, "Speech disorder ": 4.318665600082211, "Stereotypy ": 36.10581657759274, "Sudden onset of sleep ": 37.57989661377093, "Therapeutic product effect decreased ": 2.360618906236981, "Therapeutic response shortened ": 38.01429181564257, "Therapy cessation ": 11.894260365424236, "Tremor ": 4.080310487581091, "Urinary tract infection ": 2.007486362317123, "Weight decreased ": 2.2238754835402563, "Wrong technique in product usage process ": 16.15472535526383} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1012.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1012.json new file mode 100644 index 00000000000..c592709f144 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1012.json @@ -0,0 +1 @@ +{"Abdominal pain ": 3.699398444925811, "Lactic acidosis ": 59.73239803503783, "Lipoatrophy ": 502.6771923047401, "Pancreatitis ": 11.936607486507832} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1013.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1013.json new file mode 100644 index 00000000000..6f122d69b0e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1013.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 6.960912366184648, "Abdominal operation ": 11.840779213632006, "Abortion infected ": 88.12870733460751, "Abortion 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3.8059938970856826, "Arthritis ": 3.6405362883350216, "Arthropod bite ": 2.9130739977496747, "Atypical mycobacterial infection ": 3.319029795260676, "B-cell lymphoma ": 4.991420214786683, "Basal cell carcinoma ": 8.330572904961754, "Bladder neoplasm ": 5.8638801915177385, "Bladder transitional cell carcinoma ": 11.079576587519878, "Breast cancer ": 4.344058011181831, "Breast mass ": 2.617489181329035, "Breast neoplasm ": 8.776848910864139, "Bronchitis ": 2.15648258790678, "Caesarean section ": 2.4616034414355474, "Cardiac operation ": 2.628154024560199, "Cellulitis ": 4.3964861939240265, "Cervical dysplasia ": 7.805708883577505, "Cervical vertebral fracture ": 2.2355472941953085, "Cervix carcinoma ": 2.134880953971502, "Chemotherapy ": 3.697481047054121, "Chikungunya virus infection ": 49.95849854468705, "Cholangitis sclerosing ": 7.421446259978675, "Cholecystectomy ": 5.7961412092404005, "Cholelithiasis ": 2.045257067996521, "Chronic disease ": 26.21151830536997, "Chronic lymphocytic leukaemia ": 2.3991604494744405, "Chronic myeloid leukaemia ": 2.346138567019594, "Clear cell renal cell carcinoma ": 4.801484228443972, "Clostridial infection ": 5.705236537077241, "Clostridium difficile infection ": 6.18318996170692, "Coccidioidomycosis ": 9.334452148806136, "Coccydynia ": 6.045530878668987, "Colectomy ": 17.507295587014674, "Colitis ulcerative ": 19.80281446318024, "Colon cancer ": 5.552560327019312, "Colorectal adenoma ": 4.349670037640452, "Colostomy ": 5.436819374679723, "Contraindication to vaccination ": 23.572072984803462, "Coronary arterial stent insertion ": 2.0227760323496184, "Crohn's disease ": 131.31561946596375, "Cutaneous T-cell lymphoma ": 15.99533942264466, "Cutaneous lupus erythematosus ": 7.183607367704875, "Cutaneous vasculitis ": 4.006131818011896, "Cytomegalovirus colitis ": 2.9818221076560363, "Dactylitis ": 15.366639016387698, "Decreased immune responsiveness ": 3.09993640198383, "Defaecation urgency ": 6.1005318686765335, "Dengue fever ": 7.110031173772447, "Dermatitis atopic ": 2.10192665890181, "Dermatitis exfoliative ": 4.428765566129229, "Dermatitis exfoliative generalised ": 4.55929474361749, "Dermatitis psoriasiform ": 2.7093565402621667, "Device defective ": 5.540496540404582, "Device deployment issue ": 40.498033954947694, "Device issue ": 4.895360930119673, "Device leakage ": 3.751758283657114, "Diarrhoea haemorrhagic ": 2.803135681677146, "Dilated cardiomyopathy ": 4.698417020725785, "Disability ": 2.4069482860646376, "Diverticulitis ": 3.0252366985001715, "Drug delivery system malfunction ": 5.531785482182477, "Drug exposure before pregnancy ": 5.010723766828972, "Drug ineffective ": 3.206103955763131, "Drug level below therapeutic ": 20.096254800846705, "Drug level decreased ": 11.686140961089244, "Drug specific antibody ": 3.96007700881108, "Dysplasia ": 6.553030304113835, "Ear infection ": 2.352844292046478, "Eczema ": 2.0403560357318518, "Endometrial cancer ": 5.815611036089845, "Endometriosis ": 2.597790926746449, "Endometritis ": 9.334452148806136, "Enterocutaneous fistula ": 16.335500742435432, "Enterostomy ": 31.851220588339142, "Eosinophilic pneumonia ": 3.113102111251873, "Erysipelas ": 7.554391563057245, "Erythema nodosum ": 3.3863449711733127, "Erythrodermic psoriasis ": 47.99823248833443, "Escherichia urinary tract infection ": 2.1531959699189174, "Exposure during pregnancy ": 6.608454595008656, "Eye operation ": 2.238253465977187, "Faecal calprotectin ": 207.83064511139128, "Faecal calprotectin abnormal ": 120.084180795123, "Faecal calprotectin increased ": 25.701871949285337, "Fistula ": 31.488543362110903, "Fistula discharge ": 30.4405988832484, "Follicular lymphoma ": 7.292687689552457, "Foot operation ": 2.586664427906689, "Frequent bowel movements ": 3.614095293989173, "Furuncle ": 2.379078965461604, "Gallbladder operation ": 3.60637943280836, "Gastric cancer ": 2.1008916435810434, "Gastrointestinal carcinoma ": 2.739923497308524, "Gastrointestinal infection ": 3.727768642059204, "Gastrointestinal inflammation ": 3.315620923347393, "Gestational diabetes ": 2.0095745357204344, "Gingivitis ": 2.7356693109955748, "Glioblastoma ": 4.795264726169499, "Graves' disease ": 2.1790196192723497, "Guttate psoriasis ": 36.026738477223056, "HIV infection ": 6.786152554688027, "Haematochezia ": 3.0657996835981964, "Henoch-Schonlein purpura ": 2.8506316466668613, "Hepatic cirrhosis ": 2.728134725249486, "Hepatic steatosis ": 2.27106221744866, "Hepatitis B ": 2.38344385803842, "Hernia ": 5.810440246909886, "Herpes ophthalmic ": 2.918707663223381, "Herpes virus infection ": 3.8324399324179312, "Hidradenitis ": 6.703902584385763, "Hip surgery ": 2.9971319148639286, "Hodgkin's disease ": 6.94850986938331, "Human papilloma virus test positive ": 4.071880291253221, "Hysterectomy ": 5.71035751410505, "Idiopathic intracranial hypertension ": 2.6763360230973765, "IgA nephropathy ": 9.598885732283458, "Ileal stenosis ": 38.1496453799906, "Ileostomy ": 20.803512751705878, "Immunosuppression ": 2.873254307844572, "Impetigo ": 4.270597814197234, "Inappropriate schedule of product administration ": 7.030303408050163, "Incorrect dose administered ": 2.2632884017835764, "Incorrect route of product administration ": 2.516594297263296, "Infective spondylitis ": 17.41323762565731, "Infertility ": 3.4362253054291165, "Inflammatory bowel disease ": 13.420157442534055, "Infusion related reaction ": 6.866808505768802, "Intervertebral discitis ": 4.989373212359169, "Intestinal obstruction ": 7.975874668911324, "Intestinal operation ": 33.542110172196026, "Intestinal perforation ": 3.221121869111768, "Intestinal resection ": 36.60298156918995, "Intestinal stenosis ": 91.77072364467506, "Intestinal ulcer ": 4.220595513349275, "Intracranial aneurysm ": 2.792653939806947, "Intraductal proliferative breast lesion ": 7.059027030616733, "Invasive ductal breast carcinoma ": 3.4566542650126584, "Iron deficiency anaemia ": 2.88500398146181, "Joint noise ": 2.070339173151736, "Kidney infection ": 2.7069662444856606, "Knee arthroplasty ": 3.203501352058184, "Knee operation ": 5.823361416734164, "Large intestinal stenosis ": 21.046049191351887, "Large intestine perforation ": 2.1770731602451368, "Laryngeal cancer ": 9.670535321309991, "Latent tuberculosis ": 56.52300315935105, "Leukaemia ": 2.1177966329264737, "Limb operation ": 2.7093565402621667, "Lipoma ": 7.266525397216478, "Liquid product physical issue ": 5.76983259568185, "Loss of therapeutic response ": 52.34013902510119, "Lower respiratory tract infection ": 3.677432021359204, "Lung adenocarcinoma ": 9.394738266102213, "Lung cancer metastatic ": 4.489651987862212, "Lung neoplasm ": 3.1548024165754045, "Lung neoplasm malignant ": 2.9350670277153568, "Lupus-like syndrome ": 6.700268150139073, "Lyme disease ": 3.802317427090035, "Lymphocytosis ": 2.5500494780499463, "Lymphoma ": 5.056050739083417, "Malignant melanoma ": 8.22177690420082, "Malignant melanoma in situ ": 6.499803782123895, "Malnutrition ": 2.0192239115484565, "Mastitis ": 2.783530067193339, "Meningioma ": 3.267509000760177, "Meniscus injury ": 2.159682843530743, "Metabolic surgery ": 9.414893098362, "Metastatic squamous cell carcinoma ": 20.30149001189801, "Multiple sclerosis ": 2.551347505634536, "Mycobacterium tuberculosis complex test positive ": 54.70661375516564, "Myocardial infarction ": 2.5867038276028844, "Nail psoriasis ": 16.925933751935, "Needle issue ": 14.151751896262011, "Nephrolithiasis ": 2.9541414888518185, "Non-Hodgkin's lymphoma ": 3.069883371997933, "Off label use ": 6.021315777504968, "Oral infection ": 3.2720420714586163, "Osteitis ": 5.941926689676518, "Osteomyelitis ": 2.7519021333146845, "Otitis externa ": 5.734648203180128, "Palmoplantar pustulosis ": 12.212346205089586, "Pancreatitis relapsing ": 4.349670037640452, "Papilloma viral infection ": 10.148003900572236, "Paternal exposure during pregnancy ": 19.712343347763444, "Pemphigoid ": 2.347851611356385, "Periodontitis ": 7.815516190968091, "Peripheral artery thrombosis ": 2.295140996474106, "Pertussis ": 12.02394070185708, "Pharyngitis ": 2.339977142940845, "Pharyngitis streptococcal ": 2.592391030267944, "Pneumonia ": 2.0939515313756445, "Pneumonia legionella ": 6.840133106615349, "Pneumonia pneumococcal ": 3.69733247732768, "Poor quality product administered ": 4.608336841547685, "Posterior reversible encephalopathy syndrome ": 3.8796188806632, "Postoperative wound infection ": 4.089929510783841, "Pouchitis ": 28.60589190480127, "Precancerous skin lesion ": 8.80123540294716, "Pregnancy of partner ": 26.72668276872753, "Premature labour ": 3.057233923924256, "Proctocolectomy ": 63.96931646068537, "Product dose omission issue ": 9.537317791767652, "Product label issue ": 7.957760447998941, "Product leakage ": 3.318890499698033, "Product measured potency issue ": 7.045932267735833, "Product packaging issue ": 6.782418162370936, "Product packaging quantity issue ": 4.0151584796472095, "Product storage error ": 8.201716521915186, "Product use in unapproved indication ": 2.4833312958060216, "Product use issue ": 9.813735862874276, "Prostate cancer ": 6.871659265801518, "Prostate cancer metastatic ": 2.4072680104884103, "Psoriasis ": 45.92494760760212, "Psoriasis area severity index increased ": 97.88198677088477, "Psoriatic arthropathy ": 29.7299817903874, "Pustular psoriasis ": 41.76130811056303, "Pustule ": 2.5147368086316426, "Pyelonephritis ": 2.0191446390127448, "Pyoderma gangrenosum ": 16.05297493890653, "Rash pustular ": 3.182413094186707, "Rectal abscess ": 36.27013395390577, "Rectal adenocarcinoma ": 12.30189522109119, "Rectal cancer ": 10.4883039625451, "Renal mass ": 4.941227626071204, "Renal neoplasm ": 5.623926697634691, "Respiratory tract infection ": 3.6742421960699816, "Retained products of conception ": 8.556838414656077, "Rubber sensitivity ": 10.489393430444723, "Sacroiliitis ": 9.368177883226736, "Sarcoidosis ": 4.055611918109393, "Scar pain ": 8.75053224659397, "Short-bowel syndrome ": 22.62745626190997, "Shoulder operation ": 4.379247601871551, "Skin cancer ": 5.665972084085134, "Skin exfoliation ": 2.2518044513179927, "Skin infection ": 3.601260673925592, "Skin papilloma ": 4.004831047652977, "Skin plaque ": 2.625866186484655, "Small cell lung cancer ": 3.541532418394346, "Small intestinal obstruction ": 7.414550419634993, "Small intestinal perforation ": 4.4831553560990285, "Small intestinal resection ": 19.978112595099883, "Small intestinal stenosis ": 42.25839490229045, "Small intestine carcinoma ": 5.868201334005183, "Spinal fusion surgery ": 3.3247838865896604, "Spinal operation ": 3.3326781896760944, "Splenectomy ": 4.877480320874592, "Spondylitis ": 3.772376487167362, "Squamous cell carcinoma ": 13.270028462710686, "Squamous cell carcinoma of lung ": 11.694967648116554, "Squamous cell carcinoma of skin ": 5.230397285948582, "Staphylococcal bacteraemia ": 2.2548680041100884, "Staphylococcal infection ": 4.69020892587279, "Stenosis ": 9.353939235822224, "Streptococcal infection ": 5.952111671836829, "Subcutaneous abscess ": 5.217637143572428, "Subileus ": 6.204517686920676, "Surgery ": 8.179433416478334, "Syringe issue ": 71.35382302501024, "Systemic lupus erythematosus rash ": 3.639116816563101, "T-cell lymphoma ": 11.782439767724885, "Testis cancer ": 4.083491916500752, "Therapeutic product effect decreased ": 5.185790142698638, "Therapeutic product ineffective ": 5.091447313510626, "Therapeutic response decreased ": 14.964551820009689, "Therapeutic response shortened ": 5.224574648637132, "Therapy non-responder ": 5.081022335905902, "Thyroid cancer ": 5.294489618838656, "Tinea versicolour ": 15.929506415333057, "Tongue neoplasm malignant stage unspecified ": 8.10291956593776, "Tonsillitis ": 3.834665468510936, "Tooth abscess ": 10.34106619230676, "Tooth extraction ": 2.726978248761246, "Tooth infection ": 5.508861727600191, "Transitional cell carcinoma ": 21.44910115924472, "Treatment noncompliance ": 2.105287301714133, "Tuberculin test positive ": 59.56436814816962, "Tuberculosis ": 10.695655877914728, "Umbilical hernia ": 2.583810603874916, "Underdose ": 2.6275967751343385, "Upper respiratory tract infection ": 3.810089700823908, "Uterine cancer ": 3.277359316820671, "Vena cava thrombosis ": 3.4108698464370937, "Viral infection ": 3.2153666793620825, "Vitiligo ": 9.276179696745574, "Vulvovaginal mycotic infection ": 2.532104647644841, "Weight fluctuation ": 2.136139222542012, "Wrong dose ": 3.5124705460272687} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1014.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1014.json new file mode 100644 index 00000000000..12aeac27c09 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1014.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.2231581024559484, "Haemorrhoids ": 13.823249904224234, "Oedema ": 5.473815044901856, "Sprue-like enteropathy ": 16.07254395745642} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1015.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1015.json new file mode 100644 index 00000000000..1ad68caed90 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1015.json @@ -0,0 +1 @@ +{"Decreased appetite ": 15.524465486091248, "Hyperammonaemia ": 498.2714011121074} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1016.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1016.json new file mode 100644 index 00000000000..067755d012b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1016.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 4.218059667625735, "Acute hepatic failure ": 3.914022727578105, "Adenocarcinoma of colon ": 37.6148695725063, "Alanine aminotransferase increased ": 5.307689503512639, "Alpha 1 foetoprotein increased ": 8.002770564380778, "Ammonia increased ": 9.495013922609548, "Anal abscess ": 4.952402543059005, "Anal fistula ": 6.595486222015647, "Aphonia ": 2.55817137582958, "Ascites ": 7.269938269043571, "Aspartate aminotransferase increased ": 6.9644605263144, "Asthenia ": 2.4641126546249152, "Biliary obstruction ": 6.794278220510165, "Bilirubin conjugated increased ": 7.916564433898229, "Blister ": 4.34699061045532, "Blood albumin decreased ": 4.575094701203058, "Blood alkaline phosphatase increased ": 2.4160293558668413, "Blood bilirubin increased ": 18.143605970705973, "Blood lactate dehydrogenase increased ": 2.5588509426621973, "Blood pressure increased ": 2.583158091345232, "Blood thyroid stimulating hormone increased ": 5.465871739228595, "C-reactive protein increased ": 2.944054792195961, "Cachexia ": 3.156855688692747, "Cancer pain ": 17.15482893216877, "Carbohydrate antigen 19-9 increased ": 39.69305559320301, "Carcinoembryonic antigen increased ": 85.28076811996347, "Cardiac dysfunction ": 3.819022199562944, "Cell death ": 5.177619804681565, "Cholangitis ": 7.163498903841889, "Cholecystitis ": 3.506593248066369, "Chromaturia ": 3.289256791702419, "Colon cancer ": 63.01735440490184, "Colon cancer metastatic ": 91.76225954538565, "Colon cancer recurrent ": 131.97498990633417, "Colorectal cancer ": 20.789843672744063, "Colorectal cancer metastatic ": 409.7156699371501, "Colorectal cancer recurrent ": 325.45601586150894, "Colorectal cancer stage IV ": 94.30195652008835, "Coma hepatic ": 9.135235659397043, "Death ": 2.408789695133592, "Decreased appetite ": 3.940230375813604, "Dermatitis bullous ": 2.726403222348529, "Dermatitis exfoliative ": 3.8163338805428335, "Dermatitis exfoliative generalised ": 3.2921134231959983, "Diarrhoea ": 2.420094225011319, "Disease progression ": 2.331310623178662, "Disseminated intravascular coagulation ": 8.093017908698611, "Drug eruption ": 7.083534351605588, "Drug-induced liver injury ": 4.874893614331035, "Dry skin ": 2.1585553927001384, "Duodenal perforation ": 17.84452260203771, "Dysphonia ": 14.28653368540536, "Eastern Cooperative Oncology Group performance status worsened ": 9.22460950437574, "Eating disorder ": 2.40509063864275, "Erythema multiforme ": 13.90676315287218, "Faeces discoloured ": 2.045355825407793, "Gastrointestinal perforation ": 30.192403927791126, "Gastrointestinal stromal tumour ": 29.829892794878464, "General physical health deterioration ": 2.7473036898688576, "Gingival bleeding ": 2.2531532524976754, "Glossitis ": 2.8679538698210845, "Haemorrhage urinary tract ": 3.711476793133804, "Hepatic encephalopathy ": 16.78642664509995, "Hepatic failure ": 8.636632298966086, "Hepatic function abnormal ": 10.63835845570408, "Hepatic mass ": 5.137931716152903, "Hepatitis fulminant ": 7.0359841607686455, "Hepatocellular carcinoma ": 17.792609847090493, "Hepatotoxicity ": 5.156989869061184, "Hydronephrosis ": 4.055185546224528, "Hyperammonaemia ": 4.869945673019456, "Hyperbilirubinaemia ": 8.973271325476142, "Hyperkeratosis ": 21.792225227511054, "Hypertension ": 4.749046293897282, "Hyperthermia ": 2.5571918749185523, "Hypertransaminasaemia ": 2.8283745600621306, "Hypoalbuminaemia ": 5.612907304162706, "Hypocalcaemia ": 3.3513129373358432, "Hypophagia ": 2.9216083736855487, "Hypophosphataemia ": 5.704116111091675, "Hypoproteinaemia ": 6.983315686377209, "Hypothyroidism ": 4.873288170592558, "Ileus ": 5.109396343139419, "Intestinal haemorrhage ": 5.545258221650082, "Intestinal obstruction ": 3.6023502676312416, "Intestinal perforation ": 5.331124309140023, "Jaundice ": 7.761999048342339, "Jaundice cholestatic ": 4.1565007985323765, "Large intestine perforation ": 3.2184559359953058, "Liver disorder ": 6.031307863881112, "Liver function test abnormal ": 2.787069006118719, "Liver function test increased ": 4.644175037317708, "Liver injury ": 2.698425874431802, "Lower gastrointestinal haemorrhage ": 2.869987148046988, "Lymphadenopathy mediastinal ": 5.82610558980444, "Mediastinal mass ": 24.471039095289207, "Melaena ": 2.815867544417741, "Metastases to abdominal cavity ": 24.28542944959026, "Metastases to adrenals ": 14.871516198932746, "Metastases to bone ": 4.69540707373648, "Metastases to central nervous system ": 10.325037494890625, "Metastases to liver ": 23.874126517292257, "Metastases to lung ": 38.118732324234486, "Metastases to lymph nodes ": 14.775683567287034, "Metastases to pelvis ": 26.880117247900117, "Metastases to peritoneum ": 23.85734842534587, "Metastases to spine ": 3.727047530953574, "Metastasis ": 5.534298052188569, "Mouth ulceration ": 3.5164763401527064, "Mucosal disorder ": 3.035452100708784, "Mucosal inflammation ": 9.972290900157718, "Nephrotic syndrome ": 3.939537064570632, "Ocular icterus ": 8.2514143042709, "Off label use ": 6.924310047619652, "Oral mucosa erosion ": 5.666083055556985, "Oral pain ": 2.9663636300145666, "Pain of skin ": 10.981597830924182, "Palmar-plantar erythrodysaesthesia syndrome ": 108.34766489515604, "Palmoplantar keratoderma ": 19.616636582000588, "Paronychia ": 2.908198723791648, "Performance status decreased ": 3.938495428818477, "Peritonitis ": 4.713961807887195, "Physical deconditioning ": 2.156306249538904, "Plantar erythema ": 51.83478744048034, "Platelet count decreased ": 8.013341828541762, "Portal hypertension ": 3.245864818011414, "Posterior reversible encephalopathy syndrome ": 7.168029557811422, "Pre-existing condition improved ": 8.243145150574604, "Proctalgia ": 5.255582445562452, "Protein urine present ": 13.60207694931976, "Proteinuria ": 9.854963822550864, "Pulmonary cavitation ": 14.51458307726868, "Pulmonary mass ": 2.998664571389495, "Rash maculo-papular ": 2.8064116937230037, "Rash papular ": 2.395909623620382, "Rectal adenocarcinoma ": 49.00619672516794, "Rectal cancer ": 49.32310634570033, "Rectal cancer metastatic ": 113.54632127258456, "Retroperitoneal lymphadenopathy ": 16.280993968272302, "Secondary hypertension ": 25.820594936627167, "Skin disorder ": 2.6989420433026377, "Skin erosion ": 3.8239177110882583, "Skin exfoliation ": 9.657830387498988, "Skin fissures ": 14.26684554132523, "Skin induration ": 7.926535035729247, "Skin injury ": 3.837779109460167, "Skin reaction ": 2.5102875397970736, "Skin swelling ": 7.935948615628367, "Skin toxicity ": 22.72282414744539, "Skin ulcer ": 4.842441244134107, "Skin warm ": 2.887390944099752, "Skin weeping ": 12.210612125245008, "Small intestinal perforation ": 13.151896442518924, "Stevens-Johnson syndrome ": 2.54660755667294, "Stoma site haemorrhage ": 53.40505685373885, "Stomatitis ": 6.527626139106558, "Subileus ": 5.516226425844927, "Temperature intolerance ": 2.4642145382163694, "Terminal state ": 3.174351485649747, "Therapeutic product ineffective ": 3.411395627791608, "Thrombocytopenia ": 2.117580725006289, "Toxic skin eruption ": 2.683455399512715, "Transaminases increased ": 3.523237684197687, "Tumour haemorrhage ": 16.490273241596334, "Tumour marker increased ": 16.638654375736774, "Tumour necrosis ": 18.155347248931783, "Tumour pain ": 14.553877713781176, "Weight decreased ": 2.1320964262044164, "Yellow skin ": 3.511508633704869} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1017.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1017.json new file mode 100644 index 00000000000..8f56b57e53d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1017.json @@ -0,0 +1 @@ +{"Abortion induced ": 55.492594492243846, "Alanine aminotransferase increased ": 3.564923615819831, "Blood alkaline phosphatase increased ": 10.51552654387456, "Drug interaction ": 3.5488844248817992, "Gamma-glutamyltransferase increased ": 13.98440149259873, "Gynaecomastia ": 32.00288477148004, "Hepatic function abnormal ": 6.044500916883304, "Immune reconstitution inflammatory syndrome ": 50.74421148408263, "Insomnia ": 2.223301781918884, "Liver injury ": 11.968814558743084, "Overdose ": 2.905313149425483, "Platelet count decreased ": 2.614785858600858, "Pregnancy ": 36.640987519026496, "Pruritus ": 2.450197395109578, "Rash ": 6.467513327331513, "Suicide attempt ": 5.525759789595508, "Toxic skin eruption ": 23.007443378207885, "Transaminases increased ": 8.512141752935223} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1018.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1018.json new file mode 100644 index 00000000000..44fcb4425b0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1018.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 3.837093010245585, "Adrenal suppression ": 6.897087185349649, "Anhedonia ": 37.93305612535252, "Ankle fracture ": 16.419407186686197, "Anxiety ": 9.74465712378995, "Blood HIV RNA increased ": 8.017341240353831, "Blood creatine increased ": 3.9269584221099176, "Blood creatinine abnormal ": 7.6005497975066785, "Blood creatinine increased ": 6.959423137482869, "Blood phosphorus decreased ": 3.7996629517840974, "Bone cyst ": 12.0161605234461, "Bone demineralisation ": 39.78471389191874, "Bone density abnormal ": 44.9800487963953, "Bone density decreased ": 41.367314904971614, "Bone disorder ": 9.567419231356164, "Bone loss ": 44.070120219291205, "CD4 lymphocytes decreased ": 7.833713108836502, "Cervical vertebral fracture ": 4.16721827273374, "Chronic kidney disease ": 29.96690061694021, "Chronic kidney disease-mineral and bone disorder ": 14.579060174187846, "Clavicle fracture ": 11.025723719402247, "Compression fracture ": 5.807050585340042, "Craniofacial fracture ": 5.086296515270692, "Decreased activity ": 8.72562595648275, "Degenerative bone disease ": 38.18806742020685, "Dental caries ": 4.099300429734812, "Depression ": 2.185897463030438, "Drug resistance ": 2.2244384333546305, "Dysstasia ": 4.08371184445533, "Economic problem ": 47.41659546093008, "Emotional distress ": 31.391290817044823, "End stage renal disease ": 13.156522103308722, "Fanconi syndrome ": 6.001312126304554, "Fanconi syndrome acquired ": 17.07001337853639, "Fear-related avoidance of activities ": 44.68238171689551, "Femur fracture ": 4.241734620439612, "Fibula fracture ": 11.484953535141832, "Foot fracture ": 13.093899613779907, "Fracture ": 24.913703256263304, "Fractured coccyx ": 7.70458096946798, "Gene mutation identification test positive ": 16.558650560064695, "Genotype drug resistance test positive ": 10.881243385437315, "Glomerular filtration rate abnormal ": 19.99977407824438, "Glomerular filtration rate decreased ": 7.059146965188791, "Glomerular filtration rate increased ": 11.120092820898366, "HIV test positive ": 8.126243426562583, "Hand fracture ": 22.89031908264416, "Hepatitis B ": 2.094615756278807, "Hip arthroplasty ": 6.665369088413817, "Hip fracture ": 5.156764603971011, "Hip surgery ": 3.8955786074570313, "Humerus fracture ": 3.2049474000090923, "Immune reconstitution inflammatory syndrome ": 3.661143387132785, "Impaired work ability ": 2.0435730049528598, "Intervertebral disc degeneration ": 6.914664223853307, "Jaw fracture ": 9.851149821781922, "Loss of personal independence in daily activities ": 2.9151883326726065, "Lower limb fracture ": 6.724854728671521, "Meniscus injury ": 2.8838998318480638, "Multiple fractures ": 39.76729575086082, "Nephrolithiasis ": 3.5586223456193964, "Nephropathy ": 14.935658524312323, "Nephropathy toxic ": 16.302223077865932, "Osteoarthritis ": 4.125715809934811, "Osteochondrosis ": 9.733075617096606, "Osteomalacia ": 15.30060678883252, "Osteonecrosis ": 40.16079280889993, "Osteopenia ": 31.278487027827527, "Osteoporosis ": 31.576430709141217, "Osteoporotic fracture ": 4.512159499609686, "Pain ": 4.357759529926079, "Patella fracture ": 4.065729447325782, "Pathological fracture ": 5.419408444349534, "Pelvic fracture ": 2.0078561174450296, "Post-traumatic stress disorder ": 4.149638767731106, "Protein total abnormal ": 38.08103452661691, "Protein total increased ": 16.158653148413833, "Protein urine present ": 12.203197917789748, "Proteinuria ": 4.7347056716076406, "Quality of life decreased ": 8.731561370371342, "Radius fracture ": 5.277221955770337, "Renal cyst ": 2.4887361267350983, "Renal failure ": 16.00421654754964, "Renal impairment ": 5.999427301353714, "Renal injury ": 25.85561510833812, "Renal tubular disorder ": 5.482068065821315, "Renal tubular dysfunction ": 5.2914957233283, "Renal tubular necrosis ": 2.957742685840929, "Rib fracture ": 12.038808566425972, "Shoulder fracture ": 7.770960339319937, "Skeletal injury ": 24.51679949132032, "Spinal compression fracture ": 8.189066809692145, "Spinal disorder ": 3.0617460029340062, "Spinal fracture ": 9.637133745949392, "Spinal osteoarthritis ": 8.63799507832165, "Spinal stenosis ": 3.0833051558831768, "Spondylolisthesis ": 11.455756623183191, "Stress fracture ": 8.399935519389151, "Teeth brittle ": 23.07609301873647, "Thoracic vertebral fracture ": 3.348862490082252, "Tibia fracture ": 10.712464721935309, "Toe amputation ": 2.4233715198134385, "Tooth disorder ": 3.680807680656984, "Tooth extraction ": 5.042597811637255, "Tooth fracture ": 21.65263019670649, "Tooth loss ": 36.9627791881238, "Ulna fracture ": 12.727599742554318, "Upper limb fracture ": 6.600377437949353, "Vertebral foraminal stenosis ": 22.88510668025476, "Viral load increased ": 9.588219359523416, "Viral mutation identified ": 7.4161622485859, "Virologic failure ": 8.415654762306158, "Vitamin D decreased ": 5.153770237075881, "Vitamin D deficiency ": 14.623116481880254, "Walking aid user ": 4.229195771901956, "Wrist fracture ": 12.41062327368115} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1019.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1019.json new file mode 100644 index 00000000000..a7032860207 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1019.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 2.2618159254331727, "Abortion induced ": 10.19443815588424, "Abortion spontaneous ": 13.991029093548203, "Abscess limb ": 2.8444969163870018, "Accident ": 6.762251077999265, "Accident at work ": 9.39313332671235, "Accidental exposure to product ": 5.538641579097947, "Accidental exposure to product by child ": 51.65871949058116, "Accidental overdose ": 3.906873276587887, "Acute hepatitis C ": 29.492054904234347, "Adverse event ": 3.9337967290276574, "Affective disorder ": 2.5416264576307346, "Agitation neonatal ": 28.31337205127456, "Alcohol abuse ": 50.49009616089236, "Alcohol poisoning ": 2.788527834969622, "Alcohol withdrawal syndrome ": 13.518564500714602, "Alcoholism ": 13.524850524290496, "Amniotic cavity infection ": 11.133172099500111, "Amniotic fluid volume decreased ": 16.06592616913447, "Anaemia of pregnancy ": 94.80725815708314, "Anger ": 2.001304033547267, "Ankle fracture ": 3.0494537728361064, "Anxiety ": 2.198388937451164, "Appendicitis perforated ": 4.789270370465714, "Appendix disorder ": 15.236042885069162, "Arteritis ": 8.111207336119344, "Arthritis infective ": 2.492953101578481, "Attention deficit hyperactivity disorder ": 5.869074442857228, "Back disorder ": 4.939207972895123, "Back injury ": 2.531594537928948, "Behaviour disorder ": 2.2193967604555214, "Bipolar disorder ": 2.6546823123268464, "Blood testosterone decreased ": 7.850343356141138, "Borderline personality disorder ": 17.019392289535624, "Bradycardia foetal ": 4.459945284497608, "Brain injury ": 5.360301285658602, "Cardiac hypertrophy ": 6.242580803751714, "Cerebral disorder ": 3.3886342689814013, "Child neglect ": 116.90234484220994, "Cleft palate ": 2.6079772756504678, "Complication of pregnancy ": 12.302430305654587, "Concussion ": 3.867238544252468, "Congenital anomaly ": 3.179312330708469, "Craniocerebral injury ": 3.0883414613299, "Craniofacial fracture ": 7.370287345637366, "Crying ": 3.0007681073791224, "Dental caries ": 12.260898337107454, "Dependence ": 8.948206636483034, "Depression ": 2.891214143922844, "Detoxification ": 86.21226043552073, "Developmental delay ": 7.5887846433116035, "Developmental hip dysplasia ": 7.320469795924347, "Disability ": 4.5035243525296735, "Drug abuse ": 12.366158419340175, "Drug dependence ": 19.692413235083755, "Drug detoxification ": 391.7403601354425, "Drug diversion ": 58.92824727539924, "Drug effect less than expected ": 12.662908831845307, "Drug ineffective for unapproved indication ": 3.074502447124595, "Drug level fluctuating ": 12.910016547344798, "Drug screen negative ": 237.64494611689344, "Drug screen positive ": 31.266184512179965, "Drug withdrawal convulsions ": 5.4319396963362045, "Drug withdrawal syndrome ": 61.85913836699042, "Drug withdrawal syndrome neonatal ": 141.42806566129036, "Ectopic pregnancy ": 3.814897695120031, "Endocarditis ": 7.490375344788055, "Energy increased ": 8.18318350101582, "Euphoric mood ": 17.90177387073759, "Exposure during pregnancy ": 10.919754816910489, "Exposure via breast milk ": 54.04176509899519, "Extra dose administered ": 3.010074914349392, "Facial asymmetry ": 6.600815970740218, "Failure to thrive ": 5.414494186369426, "Feeling abnormal ": 2.818154086039913, "Feeling guilty ": 12.73339407539762, "Feeling jittery ": 2.551363903372269, "Feeling of body temperature change ": 5.806415910841904, "Feeling of despair ": 2.1918392229118457, "Fever neonatal ": 41.47779598071291, "Fibula fracture ": 5.898135360144878, "Foaming at mouth ": 3.3301114786820745, "Foetal distress syndrome ": 7.343852159233719, "Foetal exposure during pregnancy ": 24.32588940036343, "Foetal exposure via father ": 88.02238582520994, "Foetal growth restriction ": 6.465238408055325, "Foetal heart rate abnormal ": 7.182697200470504, "Foetal heart rate decreased ": 15.168320654258768, "Foetal hypokinesia ": 18.151206365298155, "Foot fracture ": 2.932384946720534, "Formication ": 2.823693538096489, "Gallbladder disorder ": 6.179491686137548, "Gestational diabetes ": 6.122639796010629, "Gestational hypertension ": 16.515077802070053, "Gingival disorder ": 2.8142363035856834, "Gun shot wound ": 37.69069877343805, "Hallucination ": 3.2101557455328, "Hallucination, auditory ": 4.223326806788521, "Hallucination, visual ": 2.739589857014244, "Hand fracture ": 3.003159636396897, "Head circumference abnormal ": 40.79234403401701, "Head injury ": 2.8684215703256477, "Heart disease congenital ": 3.2647461915389453, "Hepatic pain ": 3.45016794808575, "Hepatitis C ": 6.472613655317582, "High risk pregnancy ": 51.08161035876591, "Homicidal ideation ": 5.45277601633491, "Homicide ": 14.88869583374211, "Hospitalisation ": 5.327027265971126, "Hyperbilirubinaemia neonatal ": 16.18633658084823, "Hypertensive heart disease ": 3.593834878557539, "Hypoglycaemia neonatal ": 7.794614060569295, "Hypopnoea ": 2.940634881613922, "Illness ": 2.0168370197313, "Impaired driving ability ": 9.261469779098787, "Inadequate analgesia ": 8.553593895333734, "Inappropriate schedule of product administration ": 4.8563861509507165, "Inappropriate schedule of product discontinuation ": 170.14412666027445, "Incoherent ": 2.9157113473327385, "Incorrect route of product administration ": 2.0722922078997, "Infantile colic ": 175.21427846357096, "Infantile diarrhoea ": 68.77461683192561, "Infantile vomiting ": 17.59611855607073, "Injection site abscess ": 4.1172953446477125, "Injection site necrosis ": 3.434426479284284, "Insomnia ": 2.4162344840547383, "Intentional product misuse ": 6.23324655309875, "Intentional product use issue ": 5.534120197679731, "Intentional underdose ": 213.1942893543241, "Intervertebral disc degeneration ": 2.79680672844321, "Intervertebral disc disorder ": 3.107095275133679, "Intervertebral disc protrusion ": 3.641917602034987, "Irritability ": 2.823047324388566, "Jaundice neonatal ": 80.40969868606038, "Jaw fracture ": 5.824291756266206, "Joint injury ": 4.029814938029937, "Knee deformity ": 7.416733049002116, "Learning disability ": 17.16042433368738, "Libido decreased ": 3.742848708553416, "Ligament rupture ": 3.6305018078054094, "Limb crushing injury ": 19.798595992301724, "Limb injury ": 3.5477221890592454, "Lip and/or oral cavity cancer ": 12.683690788368708, "Loss of consciousness ": 2.6181734510103905, "Loss of employment ": 3.0588946057884714, "Low birth weight baby ": 20.40497803523439, "Lower limb fracture ": 3.7592135729671607, "Macrosomia ": 28.744040016204508, "Major depression ": 4.834075089151133, "Maternal exposure during pregnancy ": 8.588988252791335, "Meconium aspiration syndrome ": 62.304379222774536, "Meconium stain ": 33.18421055559569, "Medical observation ": 60.93715936813632, "Mental disorder ": 4.072375292129225, "Mental impairment ": 2.211182242728886, "Miosis ": 4.720773098128257, "Multiple cardiac defects ": 62.22198879561816, "Multiple congenital abnormalities ": 3.3340712938529053, "Nasal septal operation ": 86.29629797653344, "Neck injury ": 8.733726617050294, "Neonatal aspiration ": 55.03731513097423, "Neonatal disorder ": 48.67233379313334, "Neonatal respiratory distress ": 10.414938221429606, "Neonatal respiratory distress syndrome ": 10.154605265176643, "Neonatal seizure ": 20.166080255628472, "Nerve compression ": 4.503181881133476, "Nerve injury ": 2.3013412585414783, "No adverse event ": 2.31914639388907, "Ocular icterus ": 2.544180016405388, "Oligohydramnios ": 6.366391662804304, "Oral administration complication ": 64.07084743437848, "Ovarian cyst ": 2.2388025567298446, "Overdose ": 6.698285804535434, "Overweight ": 4.170635175804756, "Pain threshold decreased ": 165.49235665667692, "Pancreatitis chronic ": 2.418093236825073, "Panic attack ": 2.888701964811584, "Paranoia ": 7.139983385440125, "Paternal exposure during pregnancy ": 14.783800191642344, "Personal relationship issue ": 8.724636866096482, "Pharyngeal swelling ": 4.073912171359331, "Physical assault ": 8.063064019118448, "Piloerection ": 5.516033533357287, "Placenta praevia ": 21.271682447714632, "Poor feeding infant ": 26.64074560396661, "Poor sucking reflex ": 12.63857689910646, "Poor weight gain neonatal ": 76.55170159965064, "Post-traumatic stress disorder ": 5.350668358966052, "Postpartum haemorrhage ": 8.780587660818588, "Pre-eclampsia ": 10.713493428717651, "Pre-existing condition improved ": 3.794749168221852, "Premature baby ": 12.613000020992567, "Premature delivery ": 25.877519891624942, "Premature labour ": 24.61777763860196, "Premature rupture of membranes ": 8.098585419617384, "Premature separation of placenta ": 13.2070798210606, "Prescribed overdose ": 4.142747720913503, "Priapism ": 2.088614001504605, "Procedural pain ": 13.970137844451523, "Product dose omission in error ": 2.003271093613406, "Product preparation issue ": 321.30788190891906, "Product prescribing error ": 2.250476900541265, "Product use issue ": 3.362953270498493, "Psychomotor hyperactivity ": 4.9783731932162, "Psychotic disorder ": 2.4896395243094345, "Psychotic symptom ": 5.134825334271083, "Reading disorder ": 10.204851545877334, "Respiratory arrest ": 2.0044390897639754, "Respiratory depression ": 6.122183007716353, "Respiratory disorder neonatal ": 10.604916589382992, "Respiratory rate decreased ": 2.082497981554748, "Restless legs syndrome ": 2.4327105004168503, "Restlessness ": 2.5986642384327245, "Rib fracture ": 5.800062484734363, "Road traffic accident ": 14.882866851881028, "Seizure ": 2.557549528832165, "Selective abortion ": 65.30446761546476, "Selective eating disorder ": 40.35833863116071, "Shoulder fracture ": 2.1392611528795573, "Skin laceration ": 2.763378487992594, "Skull fracture ": 8.290320352565123, "Sleep apnoea syndrome ": 4.189922175011117, "Small for 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disorder ": 5.24044406874836, "Tooth erosion ": 14.6707835340572, "Tooth fracture ": 3.708419634774249, "Toothache ": 2.4500764260056265, "Toxicity to various agents ": 4.15242501818528, "Transient tachypnoea of the newborn ": 15.912317491591375, "Tremor neonatal ": 75.99515447246044, "Trisomy 21 ": 6.759020323081387, "Umbilical cord abnormality ": 14.445086620257037, "Underdose ": 11.486931876349562, "Unevaluable event ": 3.33812182149973, "Unresponsive to stimuli ": 4.271070394690093, "Upper limb fracture ": 4.540865846237788, "Uterine disorder ": 16.9348419921784, "Victim of abuse ": 65.32206147932757, "Victim of crime ": 76.69416857038044, "Victim of sexual abuse ": 36.7926682516745, "Vomiting projectile ": 5.692490690362532, "Vulvovaginal candidiasis ": 2.483180403894271, "Weight decrease neonatal ": 72.53984025747019, "Withdrawal syndrome ": 7.576035229295479, "Wrist fracture ": 2.8038879955139118, "Wrong technique in product usage process ": 8.221412740242723, "Yawning ": 9.518967689817346} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/102.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/102.json new file mode 100644 index 00000000000..f8aee1398d8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/102.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 11.366995864393528, "Alopecia ": 11.53889758522827, "Anti-cyclic citrullinated peptide antibody ": 18.884061263319705, "Anti-cyclic citrullinated peptide antibody positive ": 55.833767501792, "Arthropathy ": 21.884931133281384, "Atelectasis ": 27.950465274634503, "Autoimmune disorder ": 8.58288867959757, "Barrett's oesophagus ": 72.22825313802474, "Blister ": 20.85342885254644, "Blood cholesterol increased ": 3.198187677916212, "Bursitis ": 6.845969820040452, "C-reactive protein abnormal ": 8.214585091180096, "Computerised tomogram thorax ": 490.7821148960112, "Computerised tomogram thorax abnormal ": 127.24802931445866, "Condition aggravated ": 6.533140997070747, "Confusional state ": 8.304303866771997, "Contraindicated product administered ": 19.48181001863859, "Contusion ": 17.2122099043093, "Deep vein thrombosis postoperative ": 27.82150165726569, "Discomfort ": 22.677592482980696, "Drug hypersensitivity ": 2.810212022339558, "Drug intolerance ": 7.682090277745229, "Duodenal ulcer perforation ": 90.4668098392763, "Dyspepsia ": 2.4009209694429616, "Dyspnoea ": 2.645207755199389, "Erosive oesophagitis ": 194.66640392393444, "Eructation ": 14.993387411042413, "Facet joint syndrome ": 9.568040256098945, "Folliculitis ": 67.6329721027273, "Gastrointestinal disorder ": 21.184427968686084, "General physical health deterioration ": 12.675750125958908, "Glossodynia ": 31.26092587474628, "Haematemesis ": 7.128921403952469, "Haematoma ": 2.2415298008861395, "Hand deformity ": 45.12003483895201, "Helicobacter infection ": 82.99315107728042, "Hepatic enzyme increased ": 16.99299136086368, "Hypersensitivity ": 8.025801396188982, "Hypoxia ": 3.6506345400712936, "Ill-defined disorder ": 36.56523764826924, "Impaired healing ": 50.58495734397461, "Infection ": 12.10962647505432, "Infusion related reaction ": 19.524010325729176, "Injury ": 17.91978046365896, "Irritable bowel syndrome ": 12.84806847105128, "Lower respiratory tract infection ": 3.8057202539450303, "Muscle injury ": 10.68946862316932, "Oesophageal haemorrhage ": 221.55515272500247, "Oesophageal mucosal dissection ": 3985.207007354716, "Oropharyngeal discomfort ": 10.805707007532696, "Regurgitation ": 58.52446894248711, "Respiratory syncytial virus infection ": 11.862777383961882, "Vitamin B12 deficiency ": 48.45176838222381} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1020.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1020.json new file mode 100644 index 00000000000..9b8b3923d27 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1020.json @@ -0,0 +1 @@ +{"Amnesia ": 58.49653583304914, "Anxiety ": 2.5182975219052115, "Chemical submission ": 19458.108500057097, "Drug abuse ": 86.9809708477372, "Drug dependence ": 7.616059680106968, "Injection ": 13466.474301417627, "Loss of consciousness ": 4.45683785537527, "Somnolence ": 3.336490258118699, "Substance abuse ": 39.7798324017028, "Vomiting ": 2.046888396228674} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1021.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1021.json new file mode 100644 index 00000000000..11fff37bd1e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1021.json @@ -0,0 +1 @@ +{"Acute generalised exanthematous pustulosis ": 7.403251602720803, "Acute pulmonary oedema ": 8.897214010958006, "Acute respiratory distress syndrome ": 4.355654829220852, "Allergy test negative ": 186.1501833360041, "Anaesthetic complication ": 65.0873203784674, "Anaesthetic complication neurological ": 893.9317810214162, "Anaphylactic reaction ": 16.49165084679229, "Anaphylactic shock ": 109.9967214958737, "Anaphylactoid reaction ": 19.71177305225272, "Anaphylactoid shock ": 212.05232038263395, "Apnoea ": 3.863862385315131, "Atrioventricular block ": 7.754753396190877, "Blood pressure decreased ": 4.48086459989658, "Bradycardia ": 6.111201408025092, "Bradypnoea ": 12.13644301079264, "Bronchospasm ": 67.14935774584228, "Bronchospasm paradoxical ": 74.50156901244907, "Cardiac arrest ": 12.445443274570842, "Cardio-respiratory arrest ": 11.00704668139615, "Cardiogenic shock ": 7.741719728053575, "Cholestasis ": 6.9087089196938845, "Circulatory collapse ": 15.04516960572782, "Coma ": 2.6877120496775144, "Conjunctivitis ": 4.023517925245391, "Cyanosis ": 3.114022813421758, "Eosinophilia ": 6.226639698414206, "Erythema ": 7.066948133596795, "Exposure during pregnancy ": 3.6708429368905486, "Gastritis ": 3.1270129199642613, "Haemodynamic instability ": 18.45473884285001, "Hemiplegia ": 4.1239994903891946, "Hepatic cytolysis ": 7.54066673128345, "Histamine level increased ": 233.4923689841373, "Horner's syndrome ": 157.79323117684072, "Hypersensitivity ": 2.066344387904365, "Hyperthermia malignant ": 133.87630810898844, "Hypotension ": 15.766277213390202, "Hypotonia ": 3.034198419847066, "Hypoxia ": 4.237604610999548, "Inadequate analgesia ": 40.11323721734267, "Incorrect route of product administration ": 2.829203323601296, "Laryngospasm ": 9.679819183490704, "Macule ": 19.15446590647125, "Maternal exposure during delivery ": 66.73311128693486, "Maternal exposure during pregnancy ": 3.148377370358524, "Miosis ": 9.856369291838975, "Myoclonus ": 5.079150875332176, "Neuromuscular blockade ": 151.23454294364646, "Normal newborn ": 9.741556511994713, "Oxygen saturation decreased ": 4.890392953782203, "Paraparesis ": 15.96645380539012, "Pneumonia aspiration ": 5.033002883227971, "Pneumothorax ": 3.622375758224646, "Postoperative delirium ": 809.6657414852194, "Premature baby ": 2.173504966771082, "Procedural hypotension ": 104.79014404852744, "Radiculopathy ": 5.971469817310013, "Rash ": 2.5161780624334424, "Rash maculo-papular ": 4.735983068484234, "Rash morbilliform ": 4.77817246800226, "Respiratory arrest ": 3.5092173992090943, "Respiratory depression ": 21.54729923188729, "Sedation ": 4.0074381768675975, "Sedation complication ": 10.832595028660094, "Shock ": 22.7803855869522, "Shock haemorrhagic ": 4.612095962920212, "Stress cardiomyopathy ": 34.463940685367675, "Tachycardia ": 6.672075120743633, "Toxic epidermal necrolysis ": 2.765564380201957, "Toxic skin eruption ": 5.716324515093811, "Type I hypersensitivity ": 50.08235675337304, "Urinary incontinence ": 2.5027041985782965, "Urticaria ": 4.307513226225706, "Ventricular extrasystoles ": 4.634709394888435, "Ventricular tachycardia ": 2.9120515816660024, "Withdrawal syndrome ": 2.6950279545415987} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1022.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1022.json new file mode 100644 index 00000000000..fc05bab5de0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1022.json @@ -0,0 +1 @@ +{"Anaphylactic reaction ": 45.18999043806067, "Anaphylactic shock ": 25.2329362032695, "Atrial fibrillation ": 8.112470490368743, "Bradycardia ": 22.04753909079276, "Bronchospasm ": 39.75421879118719, "Cardiac arrest ": 16.758361704744704, "Drug interaction ": 9.928121370377337, "Hypotension ": 6.91606460622092, "Neuromuscular block prolonged ": 783.3574580078387, "Neuromuscular blockade ": 1233.7163544188072, "Off label use ": 2.7866687772480945, "Recurrence of neuromuscular blockade ": 1591.5272849619423, "Respiratory failure ": 24.708500671039577, "Tachycardia ": 4.160834080250067} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1023.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1023.json new file mode 100644 index 00000000000..17dc5e56574 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1023.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 16.54972415045368, "Clostridium difficile colitis ": 13.851988879341262, "Decreased appetite ": 2.062683688096459, "Diarrhoea ": 2.794456665558751, "Disease progression ": 13.34261564834975, "Drug interaction ": 6.668701108923167, "Electrocardiogram QT prolonged ": 16.8902170475667, "Epistaxis ": 2.618178916718264, "Hair colour changes ": 30.246649169899676, "Hypertension ": 8.780290190764378, "Hypothyroidism ": 18.01285600587825, "Leukopenia ": 4.028926241635756, "Malignant neoplasm progression ": 4.075736551178736, "Mucosal inflammation ": 17.0382805141317, "Neoplasm progression ": 6.036755141801905, "Nephrotic syndrome ": 23.75094271928633, "Neutropenia ": 4.956532731235687, "Osteonecrosis of jaw ": 86.25154931662397, "Pain in jaw ": 8.918078838186114, "Palmar-plantar erythrodysaesthesia syndrome ": 21.856100254812542, "Periodontal disease ": 259.7499988829635, "Posterior reversible encephalopathy syndrome ": 22.447372708534235, "Proteinuria ": 9.455354143398926, "Stomatitis ": 4.320431895169893, "Thrombocytopenia ": 5.872105572323824, "Thrombotic microangiopathy ": 30.93138083052052} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1024.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1024.json new file mode 100644 index 00000000000..f5c132db0f1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1024.json @@ -0,0 +1 @@ +{"Agitation ": 3.851180370650725, "Depression ": 4.237372718495712, "Drug interaction ": 3.341036344521052, "Foetal exposure during pregnancy ": 3.8997189349624337, "Gamma-glutamyltransferase increased ": 14.588066774648752, "General physical health deterioration ": 3.373776232891266, "Hallucination ": 4.280479504365571, "Hepatic steatosis ": 13.683564925922584, "Hepatitis ": 8.30024654642637, "Lactic acidosis ": 10.085088378464995, "Nightmare ": 8.542291872123538, "Pancreatitis ": 3.2123651582107637, "Pancreatitis acute ": 12.270590573638067, "Rash maculo-papular ": 7.275481477147968, "Suicidal ideation ": 5.695086941939819} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1025.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1025.json new file mode 100644 index 00000000000..42c53ac85e8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1025.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 2.33927761709552, "Abdominal infection ": 3.7622424389805738, "Acute cholecystitis necrotic ": 7.110934820664927, "Ageusia ": 7.004511393798643, "Alveolar soft part sarcoma ": 15.9222770164308, "Anaemia ": 2.3983769610776533, "Anal abscess ": 4.059823448383918, "Anal fissure ": 4.543848224075102, "Anal fistula ": 4.899021518653251, "Anal haemorrhage ": 8.00869605571562, "Anal inflammation ": 10.1634339600209, "Anal injury ": 36.23832607887527, "Anal ulcer ": 8.107736793229172, "Angular cheilitis ": 4.024162274141954, "Anorectal discomfort ": 4.3090965652021485, "Anorectal disorder ": 5.018349112826401, "Aortic dissection ": 3.995738296764016, "Aphthous ulcer ": 5.682940200067657, "Appetite disorder ": 2.6855515473252405, "Ascites ": 4.018100715684891, "Asthenia ": 2.172801656180704, "Blister ": 3.3221446835384087, "Blister infected ": 6.372988206573382, "Blood albumin decreased ": 2.6280549115164717, "Blood bilirubin abnormal ": 3.538830123282134, "Blood blister ": 3.5004321521275648, "Blood calcium abnormal ": 2.5777052270661347, "Blood calcium increased ": 2.3029227123000924, "Blood creatine increased ": 2.75239839647671, "Blood creatinine abnormal ": 3.4524950848508937, "Blood creatinine increased ": 2.315404100599315, "Blood disorder ": 3.284611634510012, "Blood magnesium decreased ": 3.281181068070249, "Blood pressure abnormal ": 2.330076202578719, "Blood pressure fluctuation ": 2.0213474368525723, "Blood pressure increased ": 3.850220793460661, "Blood sodium decreased ": 3.658669198138153, "Blood sodium increased ": 2.228579761191265, "Blood test abnormal ": 2.342002291788698, "Blood thyroid stimulating hormone abnormal ": 5.23065625266773, "Blood thyroid stimulating hormone decreased ": 2.0195331748934207, "Blood thyroid stimulating hormone increased ": 14.966120304829834, "Blood triglycerides abnormal ": 3.5956512679216903, "Blood urea increased ": 2.212229675120896, "Blood uric acid increased ": 2.141116813551358, "Blood urine ": 7.691889612945651, "Blood urine present ": 4.38386728486451, "Bone lesion ": 2.530411534599225, "Burn oesophageal ": 2.1678413293455363, "Burn oral cavity ": 6.895541164197233, "Cachexia ": 2.438355218905389, "Cancer pain ": 8.961721650194969, "Carcinoid tumour ": 3.384368532312146, "Cardiac failure ": 2.4896471732445598, "Cardiopulmonary failure ": 24.86169045308845, "Cardiotoxicity ": 2.1792122194219776, "Central hypothyroidism ": 2.7399719840646366, "Chapped lips ": 5.867829370594369, "Cholecystitis ": 3.4512727976846582, "Cholecystitis infective ": 5.337919942627307, "Chromaturia ": 3.326256621772179, "Clear cell renal cell carcinoma ": 9.14123095287988, "Colonic fistula ": 7.961687045441544, "Coma hepatic ": 2.4197168042214634, "Constipation ": 2.528345549625667, "Death ": 5.636203431318115, "Decreased appetite ": 4.008740862829962, "Decreased immune responsiveness ": 7.925060994124159, "Decubitus ulcer ": 6.584985154215838, "Dehydration ": 3.1335681866950984, "Diarrhoea ": 2.668875619308291, "Disease progression ": 32.37213242999277, "Disseminated intravascular coagulation ": 2.1244101766053984, "Diverticular perforation ": 2.4188467729249146, "Dry mouth ": 2.3029525638756594, "Dry skin ": 9.181740863655849, "Duodenal perforation ": 2.306487337593943, "Dyschezia ": 3.758211698030864, "Dysentery ": 5.161426751683807, "Dysgeusia ": 3.3466316481267917, "Dyspepsia ": 3.971632303765347, "Eating disorder ": 8.329306325406447, "Ejection fraction decreased ": 4.432018867359169, "Epistaxis ": 3.755490667230447, "Eructation ": 2.502786830929825, "Exposed bone in jaw ": 18.616578988131163, "Eye colour change ": 5.289412305891497, "Eye swelling ": 2.502442721798147, "Eyelash discolouration ": 44.67562738771224, "Eyelid oedema ": 2.043527707878632, "Eyelid pain ": 2.306487337593943, "Faeces discoloured ": 2.147151199321915, "Faeces soft ": 2.475496174019185, "Feeding disorder ": 6.7665132466120825, "Fistula ": 3.5031858035228205, "Fistula of small intestine ": 9.323755396881577, "Flatulence ": 4.166439158126159, "Fluid intake reduced ": 5.140574056325409, "Food 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7.526787478674223, "Hyperaesthesia ": 2.661547640044298, "Hyperaesthesia teeth ": 2.502510690870667, "Hyperchlorhydria ": 16.614087871867753, "Hypercreatininaemia ": 2.9382717978859705, "Hyperkeratosis ": 19.395564874249903, "Hypertension ": 4.111030098479426, "Hyperthyroidism ": 2.772412570594056, "Hypoalbuminaemia ": 2.456992256620264, "Hypogeusia ": 11.051951425204097, "Hypophagia ": 4.352521262473482, "Hypothyroidism ": 8.881466818030372, "Impaired healing ": 2.786844517765515, "Incision site pain ": 5.733813722048219, "Ingrowing nail ": 3.779585730062008, "Inguinal hernia ": 2.2976566249673835, "Internal haemorrhage ": 2.5777776666964924, "Intestinal fistula ": 5.006097738890476, "Intestinal haemorrhage ": 2.5873097608556184, "Intestinal obstruction ": 2.1193668126298646, "Intestinal perforation ": 4.532469958492267, "Jaundice ": 2.2536639121021818, "Jaw disorder ": 4.672250491338108, "Lacrimal disorder ": 6.918533337798009, "Lacrimation increased ": 2.35558299120903, "Large 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8.682577424173445, "Nail bed bleeding ": 4.857093848368591, "Nail discolouration ": 5.7942836014471215, "Nail disorder ": 2.415419447979621, "Nasal discomfort ": 2.9590174337254664, "Nasal disorder ": 4.633536241178054, "Nasal dryness ": 4.625529522228055, "Nasal injury ": 5.564279729652812, "Nasal septum perforation ": 3.333255921609096, "Neoplasm malignant ": 2.373006754990978, "Neoplasm progression ": 34.32529094049958, "Neoplasm recurrence ": 4.997523244286912, "Nephrectomy ": 2.84234231184438, "Nephrotic syndrome ": 8.499525200018242, "Nodule ": 2.042683594566028, "Noninfective gingivitis ": 4.421411936043727, "Nutritional condition abnormal ": 3.58081522979573, "Ocular vascular disorder ": 2.769495280217558, "Oesophageal haemorrhage ": 3.692904151301261, "Oesophageal ulcer ": 4.2642676942846585, "Oesophagitis ": 2.1064233860845234, "Oesophagitis ulcerative ": 3.763293724415581, "Onychalgia ": 5.006097738890476, "Onychoclasis ": 2.2768250086522146, "Onycholysis ": 2.3182319402534266, "Oral discomfort ": 6.408973951329068, "Oral disorder ": 5.317212899986992, "Oral infection ": 2.229559121109506, "Oral mucosal blistering ": 8.637353692483547, "Oral mucosal erythema ": 4.039736141105351, "Oral mucosal exfoliation ": 4.491476899651225, "Oral pain ": 19.97053325621103, "Orbital oedema ": 4.659195817524316, "Organ failure ": 8.207455905864984, "Oropharyngeal plaque ": 3.277288597469136, "Osteonecrosis of jaw ": 12.097106933796264, "Palmar erythema ": 4.192009470704741, "Palmar-plantar erythrodysaesthesia syndrome ": 24.47753708966814, "Pancreatic neuroendocrine tumour ": 20.865581339530547, "Pancreatic neuroendocrine tumour metastatic ": 12.176925220462872, "Pathological fracture ": 2.895902767683288, "Penile exfoliation ": 12.010963633660152, "Penile haemorrhage ": 3.411882391631947, "Pericardial effusion ": 2.127330191892572, "Perineal pain ": 4.011127567991756, "Periorbital oedema ": 4.995571697315627, "Peritonitis ": 2.16712664023413, "Phaeochromocytoma ": 2.6045755469495013, "Pharyngeal inflammation ": 2.286738651842473, "Pharyngeal ulceration ": 3.232718349059031, "Pigmentation disorder ": 2.337134739937951, "Plantar erythema ": 14.82722095857907, "Platelet count decreased ": 7.032405069777323, "Platelet disorder ": 2.532136574134029, "Pleural effusion ": 3.764100273041752, "Pneumatosis intestinalis ": 2.0832170272996344, "Posterior reversible encephalopathy syndrome ": 2.1505904583878857, "Primary hypothyroidism ": 5.188114909023682, "Proctalgia ": 6.404359917165865, "Prostatomegaly ": 2.153371764956921, "Protein total decreased ": 3.1245991730951266, "Protein urine present ": 3.368216321373712, "Proteinuria ": 2.8028325769048084, "Pulmonary oedema ": 2.3141985602382054, "Purulence ": 2.782302584296983, "Pyoderma gangrenosum ": 5.948989701493863, "Rectal abscess ": 2.927260241353654, "Rectal ulcer ": 3.1452322596386515, "Red blood cell abnormality ": 2.321133591053897, "Red blood cell count decreased ": 3.086846578551244, "Reflux gastritis ": 7.967870008859985, "Renal cancer ": 8.196619117836741, "Renal cancer metastatic ": 99.11700097665268, "Renal cancer stage IV ": 61.7367832319189, "Renal cell carcinoma ": 136.53176194939937, "Renal cell carcinoma stage IV ": 33.89965694990128, "Renal disorder ": 2.265627252494817, "Renal haemorrhage ": 4.499243594438481, "Renal impairment ": 2.3718856591834614, "Renal vein thrombosis ": 3.4076818106792226, "Retching ": 2.907338384071568, "Scrotal erythema ": 9.50916987747825, "Second primary malignancy ": 18.21572432809746, "Single functional kidney ": 4.721703389372228, "Skin abrasion ": 2.739269224730219, "Skin atrophy ": 6.306909146285564, "Skin depigmentation ": 4.1650298740959295, "Skin discolouration ": 5.656792768959901, "Skin disorder ": 2.813063745046134, "Skin exfoliation ": 6.4994912659254, "Skin fissures ": 15.582741294057357, "Skin haemorrhage ": 3.2628695218153405, "Skin hypertrophy ": 3.940438312547662, "Skin injury ": 2.564304644407424, "Skin irritation ": 2.930000802186153, "Skin lesion ": 3.363606272604888, "Skin papilloma ": 3.456326112235839, "Skin sensitisation ": 9.767066845952687, "Skin toxicity ": 5.456806706048685, "Skin ulcer ": 3.538808031231361, "Skin wound ": 3.636546752956346, "Sluggishness ": 2.2431251981517475, "Small intestinal perforation ": 2.0281414308822, "Spinal disorder ": 2.265858888139252, "Stomatitis ": 10.170597585774994, "Sweat discolouration ": 8.891895817495675, "Taste disorder ": 13.197897258188377, "Temperature intolerance ": 2.4802620551109054, "Testicular disorder ": 2.0327858945438604, "Testicular swelling ": 2.178794798929398, "Throat lesion ": 12.909425879042338, "Thrombocytopenia ": 3.39318870202276, "Thrombotic microangiopathy ": 2.2883090351839863, "Thrombotic thrombocytopenic purpura ": 2.1413072259441828, "Thyroid disorder ": 9.351179517078643, "Thyroid function test abnormal ": 10.94891047790884, "Thyroid hormones increased ": 3.547704337880089, "Thyroxine 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"Weight decreased ": 3.190539687194948, "Weight fluctuation ": 5.697457395267292, "White blood cell count decreased ": 2.9915391305018275, "Wound ": 2.439009887370276, "Wound complication ": 4.933854576239964, "Wound dehiscence ": 4.327304024824957, "Wound haemorrhage ": 2.5952005525565465, "Wound infection ": 2.8504652179302346, "Yellow skin ": 81.64724897614563} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1026.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1026.json new file mode 100644 index 00000000000..c1671e50250 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1026.json @@ -0,0 +1 @@ +{"Adverse event ": 6.207632202515212, "Agitation ": 3.840086729726572, "Akathisia ": 54.24927311229766, "Blood creatine phosphokinase increased ": 4.372535158103086, "Bradykinesia ": 44.57062450084656, "Delirium ": 2.5435506695251493, "Disease recurrence ": 4.334377342903216, "Disorientation ": 6.522114262989159, "Drug-induced liver injury ": 3.634151464170952, "Dysarthria ": 11.53932727711263, "Dysgeusia ": 10.523392391982188, "Dyskinesia ": 9.832642160628982, "Dysphagia ": 3.72985930246459, "Dystonia ": 11.28204736198916, "Electrocardiogram QT prolonged ": 2.6684345088925614, "Extrapyramidal disorder ": 65.71557977440469, "Generalised tonic-clonic seizure ": 6.330328912397482, "Hospitalisation ": 3.449759212018085, "Hypoaesthesia oral ": 22.59341818626025, "Incorrect route of product administration ": 23.306713323462887, "Increased appetite ": 13.876496757354449, "Insomnia ": 2.409123188764614, "Mania ": 13.290526507603497, "Muscle rigidity ": 13.567981271452318, "Muscle twitching ": 3.480614704247663, "Nervousness ": 2.9747076280888964, "Neuroleptic malignant syndrome ": 59.92183755876987, "Off label use ": 4.2922653260698045, "Oral dysaesthesia ": 163.14584172802412, "Paraesthesia oral ": 5.346089278198875, "Parkinsonism ": 42.65624719921861, "Pneumonia aspiration ": 12.841027614980089, "Polydipsia ": 25.35471915052848, "Prescribed overdose ": 9.10113487826083, "Product taste abnormal ": 23.7928495376452, "Psychomotor hyperactivity ": 13.140979296140326, "Restless legs syndrome ": 12.21988547548867, "Restlessness ": 6.105980804142208, "Rhabdomyolysis ": 7.34031382418971, "Salivary hypersecretion ": 9.417935945721217, "Schizophrenia ": 50.00330337169883, "Sedation ": 38.9396529498552, "Sedation complication ": 44.55508030635309, "Somnolence ": 3.4205957278044186, "Sopor ": 12.741456486049302, "Suicidal ideation ": 3.0313231557855578, "Suicide attempt ": 5.416595422515599, "Tongue oedema ": 10.430493009811324, "Tooth discolouration ": 24.008684659261984, "Treatment noncompliance ": 3.565968694159596, "Underdose ": 4.4439306238259295, "Urinary incontinence ": 9.408509834622276, "Urinary retention ": 5.11871772005341, "Water intoxication ": 158.27905800056652, "Weight increased ": 2.8009153058188665} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1027.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1027.json new file mode 100644 index 00000000000..57d11278cac --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1027.json @@ -0,0 +1 @@ +{"Disease progression ": 17.14924489097697, "Infusion related reaction ": 10.35582239423618, "Neutropenia ": 3.979092548281306, "Off label use ": 6.3660227809156655, "Pneumonia ": 2.8100841058076487, "Thrombocytopenia ": 4.5412374530405} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1028.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1028.json new file mode 100644 index 00000000000..f55a0f653f5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1028.json @@ -0,0 +1 @@ +{"Blood HIV RNA increased ": 181.838687104936, "Blood cholesterol increased ": 5.4785669164247714, "Coronavirus infection ": 52.27277024392599, "Dyslipidaemia ": 89.77957649352986, "Hypercholesterolaemia ": 53.33628903283755, "Pruritus ": 2.458791050041042, "Rash ": 3.1162971265395707, "Self-destructive behaviour ": 50.20958343048842, "Treatment noncompliance ": 10.059402853288685, "Viral load increased ": 104.16448448730864, "Weight increased ": 4.092895577177306} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1029.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1029.json new file mode 100644 index 00000000000..540956cfe5a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1029.json @@ -0,0 +1 @@ +{"Acute respiratory distress syndrome ": 2.907248433349792, "Acute respiratory failure ": 6.42624382479321, "Adenovirus infection ": 22.940543342728503, "Apnoea ": 57.086794905206126, "Apnoeic 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95.19822180250073, "Crying ": 12.579238864665786, "Cyanosis ": 17.849878465231114, "Cystic fibrosis ": 10.57188178268562, "Death ": 2.1160429983675155, "Dehydration ": 2.777474892233881, "Dermatitis diaper ": 38.7021861099303, "Developmental delay ": 3.5928155540650537, "Ear infection ": 16.310887810141697, "Electrolyte imbalance ": 2.367566494330382, "Enterovirus infection ": 64.6643884308422, "Failure to thrive ": 22.67603657821293, "Febrile convulsion ": 4.456393200026168, "Feeding disorder ": 4.40225001172453, "Fluid intake reduced ": 8.338446272164388, "Fontanelle bulging ": 90.0604154444893, "Gastroenteritis ": 10.611421096914691, "Gastroenteritis rotavirus ": 11.128835654804124, "Gastroenteritis viral ": 3.5622295088234366, "Gastrooesophageal reflux disease ": 3.5512547960246343, "Gastrostomy ": 16.171757107267304, "H1N1 influenza ": 26.584753479197943, "Heart disease congenital ": 14.403515377699994, "Hernia ": 6.27137578201339, "Hospitalisation ": 14.812632306586348, "Hydrocephalus ": 7.379805371220383, "Hypophagia ": 9.238132289677166, "Hypotonia ": 4.365242659348025, "Hypoxia ": 8.17891716182334, "Ill-defined disorder ": 3.151826655051102, "Illness ": 3.071927764491293, "Inappropriate schedule of product administration ": 2.3163840425681075, "Increased bronchial secretion ": 17.760013140355337, "Infantile spasms ": 30.43452000910176, "Infection ": 2.5192498127748544, "Influenza ": 3.18294008187578, "Inguinal hernia ": 12.191743656025077, "Irritability ": 3.815588419976157, "Lower respiratory tract infection ": 6.14019488803452, "Lung disorder ": 3.5149700029506, "Metapneumovirus infection ": 85.09869161671082, "Nasal congestion ": 8.841466414948421, "Nasopharyngitis ": 5.781711385643718, "Obstructive airways disorder ": 3.121322617869412, "Otitis media ": 25.09467310992204, "Oxygen saturation abnormal ": 11.07455627423752, "Oxygen saturation decreased ": 8.98293093621433, "Pallor ": 5.311780570315658, "Parainfluenzae virus infection ": 40.67945089811968, "Pneumonia ": 5.177931686915091, "Pneumonia aspiration ": 2.6983985035534634, "Pneumonia bacterial ": 3.4167918356732008, "Pneumonia respiratory syncytial viral ": 607.4683976830942, "Pneumonia viral ": 25.409601766476616, "Pneumothorax ": 3.628023829160131, "Poor feeding infant ": 34.438343270752696, "Product dose omission issue ": 4.635985816843809, "Pulmonary congestion ": 4.909881061699684, "Pulmonary hypertension ": 5.552956579381494, "Rales ": 3.298053290958874, "Respiration abnormal ": 4.112746645026419, "Respiratory arrest ": 5.939632004807681, "Respiratory disorder ": 10.79803298265356, "Respiratory distress ": 17.72830835778787, "Respiratory failure ": 7.963152349519801, "Respiratory rate increased ": 8.809528506131956, "Respiratory syncytial virus bronchiolitis ": 12149.277701894092, "Respiratory syncytial virus bronchitis ": 2095.93597987918, "Respiratory syncytial virus infection ": 2194.961432432083, "Respiratory syncytial virus test positive ": 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": 85.76848509527693, "Varicella ": 2.6001533191040567, "Viral infection ": 20.80593853914922, "Viral upper respiratory tract infection ": 14.998847410228054, "Wheezing ": 9.469260714909668} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/103.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/103.json new file mode 100644 index 00000000000..8ba787b6b4f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/103.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 14.522023002451462, "Acute respiratory distress syndrome ": 2.473225725195088, "Ageusia ": 2.181361147712342, "Agranulocytosis ": 2.004508894410474, "Aneurysm ": 11.413939234477873, "Angioedema ": 6.319003364052135, "Anuria ": 6.311806334429481, "Aplasia pure red cell ": 3.871015095206571, "Aspiration ": 8.440866362445334, "Bacteraemia ": 4.905619545794607, "Blood creatine phosphokinase increased ": 4.43351102993234, "Blood creatinine increased ": 4.451078524061699, "Blood potassium increased ": 2.980949670500079, "Blood pressure abnormal ": 3.1249498107860445, "Blood pressure fluctuation ": 4.2051086799948365, "Blood pressure inadequately controlled ": 4.672128060778976, "Blood pressure increased ": 4.769974440508845, "Blood urea increased ": 2.3483416919651763, "Blood uric acid increased ": 4.359030178857514, "Bradycardia ": 4.702164001275087, "Bundle branch block left ": 8.415815319945708, "Cardio-respiratory arrest ": 3.511940130569955, "Cardiogenic shock ": 2.287547268179808, "Cholestasis ": 2.1787190983906277, "Coma ": 2.5076808234509627, "Cutaneous vasculitis ": 11.180446097799289, "Dehydration ": 3.0396340788883616, "Dermatitis exfoliative generalised ": 5.291065492717791, "Dyspepsia ": 2.176995051876733, "Eczema ": 3.734160504931813, "Eosinophilia ": 5.604101010142409, "Erectile dysfunction ": 3.527306741030409, "Erysipelas ": 6.779553279918758, "Face oedema ": 2.664520571567422, "Fall ": 2.9190262884738365, "Gamma-glutamyltransferase increased ": 3.5165481676759587, "Hepatic cytolysis ": 7.711552929596273, "Hepatitis ": 2.614778871958837, "Hepatitis cholestatic ": 3.61523711838298, "Hyperglycaemia ": 2.458433156127104, "Hyperkalaemia ": 30.771762256957366, "Hypertension ": 3.3281757768879405, "Hypertensive crisis ": 5.691605589918321, "Hyponatraemia ": 10.222136889710535, "Hypotension ": 5.17404812914473, "Inappropriate antidiuretic hormone secretion ": 5.43385379790176, "Jaundice ": 2.692949878694765, "Lactic acidosis ": 8.858199242854303, "Laryngeal oedema ": 2.356605175196271, "Medication error ": 3.61114791705552, "Metabolic acidosis ": 3.2007463843106434, "Mitral valve incompetence ": 5.842035632098304, "Multiple organ dysfunction syndrome ": 2.0720312879652574, "Musculoskeletal chest pain ": 5.62416008711063, "Oedema peripheral ": 2.093100989706836, "Orthostatic hypotension ": 18.569821284318078, "Pancreatitis acute ": 3.834585210596814, "Pancytopenia ": 2.5663896581921195, "Photosensitivity reaction ": 2.920089833058851, "Pregnancy ": 3.847905238445936, "Product administration error ": 2.721008239155132, "Product availability issue ": 5.257459566306882, "Pulmonary arterial hypertension ": 4.593692058006757, "Rash vesicular ": 2.3163763357257543, "Renal failure ": 4.175709939851741, "Renal tubular necrosis ": 5.4779854899645, "Rhabdomyolysis ": 3.720166999893921, "Shock ": 4.864712114951386, "Subarachnoid haemorrhage ": 2.666652773030102, "Therapy non-responder ": 2.7032032773845627, "Tongue oedema ": 2.743262800664838, "Toxic skin eruption ": 2.158962104911723, "Tubulointerstitial nephritis ": 4.172706243859439, "Vasculitis ": 3.717784236531808, "Wrong patient received product ": 10.505764592652532, "Wrong product administered ": 2.118431224478702, "Wrong technique in product usage process ": 2.2827999164503976} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1030.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1030.json new file mode 100644 index 00000000000..59dabc41a79 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1030.json @@ -0,0 +1 @@ +{"Bronchiolitis ": 779.166294388646, "Bronchitis ": 12.84332727274147, "Cough ": 3.714649392294732, "Crying ": 9.760082668090943, "Cyanosis ": 15.050539805386926, "Febrile convulsion ": 104.2446634797766, "Gait disturbance ": 2.308275650073966, "Gastroenteritis ": 49.50427881908052, "Hypotonia ": 15.496026164217271, "Hypotonic-hyporesponsive episode ": 157.4062306832819, "Nasopharyngitis ": 5.439428078260963, "Otitis media ": 171.24733030314465, "Pharyngitis ": 41.241806972258544, "Pharyngotonsillitis ": 1141.1071288927312, "Pneumonia ": 2.5341077722995995, "Pyrexia ": 3.21711157386507, "Rhinorrhoea ": 6.683469626978567, "Seizure ": 2.5738113434731185, "Tonsillitis ": 50.87302756135354, "Upper respiratory tract infection ": 36.55224574583768} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1031.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1031.json new file mode 100644 index 00000000000..7d3acfcb1ec --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1031.json @@ -0,0 +1 @@ +{"Acute graft versus host disease ": 9.556973829554424, "Acute kidney injury ": 4.632972201997329, "Aplasia pure red cell ": 9.435409341152765, "Aspergillus infection ": 13.91952464524402, "Bacterial infection ": 4.539085156493998, "Blood creatinine increased ": 3.813735773258565, "Blood magnesium decreased ": 14.473511721623495, "Bronchopulmonary aspergillosis ": 15.253063593946726, "Candida infection ": 13.267752348376414, "Complications of transplanted kidney ": 74.50705244939448, "Contraindicated product administered ": 2.7845585326378406, "Cytomegalovirus infection ": 15.157237278663734, "Cytomegalovirus infection 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"Respiratory failure ": 2.017375804077936, "Scedosporium infection ": 118.72095024196096, "Septic shock ": 2.38036609686691, "Skin lesion ": 3.007428543531706, "Squamous cell carcinoma of skin ": 21.68212317763691, "Staphylococcal infection ": 3.4611760965196705, "Thrombotic microangiopathy ": 24.854055910318632, "Toxicity to various agents ": 4.897400962091449, "Transplant rejection ": 48.36680142436104, "Tuberculosis ": 7.325966222814844, "Varicella zoster virus infection ": 22.159620992696937} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1032.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1032.json new file mode 100644 index 00000000000..f486ce2730b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1032.json @@ -0,0 +1 @@ +{"Basal cell carcinoma ": 45.30284295792817, "Blood pressure increased ": 2.6807718043003, "Cardiac failure ": 6.524093131772856, "Drug interaction ": 2.4814046230106723, "Malignant melanoma ": 27.122319976752102, "Respiratory syncytial virus infection ": 47.11616481082915, "Toxicity to various agents ": 3.4816910427180288} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1033.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1033.json new file mode 100644 index 00000000000..76de3ff6296 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1033.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 6.895030961377874, "Cardiac failure ": 15.080049937098195, "Dyspnoea ": 2.0852597649905174, "Syncope ": 8.648635389357425} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1034.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1034.json new file mode 100644 index 00000000000..5fa98d7516e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1034.json @@ -0,0 +1 @@ +{"Asthenia ": 2.0298473465254023, "Cardiac failure ": 2.1328680971681124, "Death ": 6.644593702886772, "Disease progression ": 2.428502090800721, "Dysphagia ": 5.337199756249735, "General physical health deterioration ": 2.256908028393501, "Hospitalisation ": 3.607536407949742, "Hyperkeratosis ": 31.339646439611634, "Hyperpyrexia ": 16.748828454881412, "Malignant melanoma ": 26.51803200313268, "Malignant neoplasm progression ": 10.074603566996371, "Metastases to central nervous system ": 35.97684734159338, "Metastases to lung ": 10.738587887181808, "Metastatic malignant melanoma ": 127.91629892137396, "Neutropenia ": 2.019760512205349, "Palmoplantar keratoderma ": 337.1039155598279, "Product use in unapproved indication ": 2.324612050438269, "Pyrexia ": 3.2417323990065148, "Skin papilloma ": 56.4605016308825, "Uveitis ": 33.144610733618265} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1035.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1035.json new file mode 100644 index 00000000000..28391ada183 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1035.json @@ -0,0 +1 @@ +{"Acne ": 3.9817893001292526, "Acquired gene mutation ": 14.86060427971434, "Aplastic anaemia ": 2.4584023089024867, "Atelectasis ": 2.37771660757051, "Blood creatine phosphokinase increased ": 2.6123542299220905, "Blood sodium decreased ": 2.0135075514031517, "Body height decreased ": 4.185769001700461, "Brain neoplasm ": 6.644883522038496, "Brain oedema ": 3.1302435548088, "Carcinoembryonic antigen increased ": 42.61673227311675, "Cardiac dysfunction ": 12.327542922884517, "Cardiac failure ": 8.521493177010159, "Cardiac failure acute ": 5.251452961857661, "Cardiac failure chronic ": 3.822153430360925, "Cardiac failure congestive ": 2.5075023229947604, "Cardiac 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"Haemoptysis ": 2.417693027600344, "Heart failure with reduced ejection fraction ": 28.31332695155776, "Hepatic function abnormal ": 2.429688221568133, "Hypophagia ": 2.2703870435921254, "Interstitial lung disease ": 47.55755804580372, "Keratitis ": 19.58168248049645, "Liver disorder ": 3.2453349166959704, "Long QT syndrome ": 15.736520794768186, "Lung disorder ": 8.477348622658056, "Lung infiltration ": 2.1073581419576777, "Lung neoplasm malignant ": 8.157281600255411, "Lung opacity ": 22.832835082362784, "Lymphangiosis carcinomatosa ": 54.89363797859607, "Malignant neoplasm progression ": 23.07686060217942, "Malignant pleural effusion ": 16.791500949232315, "Metastases to bone ": 16.023886140613364, "Metastases to central nervous system ": 50.12358179331599, "Metastases to liver ": 7.575937267365127, "Metastases to lung ": 6.587186732999116, "Metastases to lymph nodes ": 7.505266377899103, "Metastases to meninges ": 80.14189619352831, "Metastases to pleura ": 27.48685934398338, "Metastases to spine ": 15.279311033087652, "Metastasis ": 19.640796287052037, "Mouth ulceration ": 2.0692533413201595, "Mucosal disorder ": 6.642481227070001, "Mucosal inflammation ": 3.283513389119108, "Myelosuppression ": 2.6984300502336844, "Nail bed inflammation ": 116.04007033133642, "Nail disorder ": 27.50616212964865, "Neoplasm progression ": 2.3573911721813654, "Neutrophil count decreased ": 2.1104475114733785, "No adverse event ": 2.7729909872459397, "Non-small cell lung cancer ": 11.60562978054623, "Onychoclasis ": 37.42974064973691, "Paronychia ": 140.35659557675618, "Pericardial effusion ": 3.709610246804262, "Platelet count decreased ": 4.392614564417044, "Pleural effusion ": 10.054866459723204, "Pneumocystis jirovecii pneumonia ": 2.552700740824178, "Pneumonia aspiration ": 2.26254680295525, "Pneumonia bacterial ": 8.470957817758496, "Pneumonitis ": 41.91260667605256, "Pneumothorax ": 6.265809169077893, "Pulmonary alveolar haemorrhage ": 4.041715289510191, "Pulmonary 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/dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1036.json @@ -0,0 +1 @@ +{"Injection site pain ": 2.943991133840602} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1037.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1037.json new file mode 100644 index 00000000000..1bf28b09ea0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1037.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 114.07796883334296, "Abnormal faeces ": 3.903878360679762, "Abortion ": 3.115044874824876, "Abortion missed ": 5.87576722310144, "Acute hepatic failure ": 3.425741380328815, "Acute respiratory distress syndrome ": 6.679424789011901, "Aggression ": 3.032944017602504, "Agitation ": 5.3963347810506255, "Altered state of consciousness ": 9.507906163289748, "Anaphylactoid reaction ": 3.8301099961695777, "Angle closure glaucoma ": 2.790985482849434, "Apgar score low ": 6.689197087648888, "Autoimmune haemolytic anaemia ": 2.522531017769136, "Blister rupture ": 10.521377997928758, "Blood creatine phosphokinase increased ": 3.2068567682790445, "Body temperature decreased ": 3.3078819957721097, "Brain death ": 4.459372039558303, "Cardiac failure acute ": 7.800588409694852, "Cardiac tamponade ": 2.7500536366681376, "Cardio-respiratory arrest ": 2.0566040796984324, "Chest X-ray abnormal ": 2.563153017956776, "Cholestasis ": 3.3356283298895386, "Chromaturia ": 5.318184432389533, "Colitis ischaemic ": 16.600111831222005, "Confusional state ": 2.8511448160267747, "Conjunctival hyperaemia ": 2.0502722129183675, "Conjunctivitis ": 2.129218440977306, "Conversion disorder ": 6.234781747084353, "Creatinine renal clearance decreased ": 2.254653211398667, "Crying ": 2.54104799896878, "Dehydration ": 2.0591875460345057, "Delirium ": 17.935615857079814, "Delirium febrile ": 48.52835963855505, "Delusion ": 14.63523803697848, "Depressed level of 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"Melaena ": 3.950543936748369, "Meningitis ": 2.1985142309196237, "Mental disorder ": 4.953582762655146, "Multiple organ dysfunction syndrome ": 3.639019186038419, "Neurological symptom ": 2.036530638883425, "Nightmare ": 8.08041709435329, "No adverse event ": 11.22079228665147, "Painful respiration ": 2.9870078531201028, "Panic attack ": 2.862934426803805, "Panic reaction ": 3.8643770514106337, "Paranoia ": 2.5087993514651235, "Pathogen resistance ": 17.821919168165415, "Periorbital swelling ": 2.1614824500275764, "Personality change ": 2.408148543568479, "Pneumonia ": 3.274296567186476, "Pneumonia bacterial ": 6.48537805099744, "Pneumonia influenzal ": 109.02266483115554, "Pneumonia viral ": 4.256901990761142, "Pregnancy ": 4.257014348911788, "Premature rupture of membranes ": 4.02042901331533, "Proteinuria ": 4.573017070850496, "Prothrombin time ratio increased ": 31.368353476497735, "Prothrombin time shortened ": 6.6192310343218805, "Psychiatric symptom ": 7.817796259819365, "Psychomotor hyperactivity ": 2.567700717582952, "Psychotic disorder ": 3.7222431832637297, "Rash morbilliform ": 3.810495463954853, "Respiratory failure ": 2.8999183535467306, "Restlessness ": 3.1186924182615128, "Rhabdomyolysis ": 3.450854041752684, "Screaming ": 6.345873868592912, "Seizure ": 4.228545496225292, "Self-destructive behaviour ": 4.547461525569352, "Sepsis ": 2.208975105164632, "Septic shock ": 2.096432832703791, "Shock ": 4.262421730175169, "Skin erosion ": 3.457178596653861, "Skin exfoliation ": 2.3195155944269445, "Sleep talking ": 11.817397149523682, "Sleep terror ": 25.045044537462992, "Somnambulism ": 7.370116070983693, "Speech disorder ": 2.358247846560329, "Staphylococcal sepsis ": 4.904903271744077, "Staring ": 3.7913434651412032, "Stevens-Johnson syndrome ": 8.785857829085096, "Stillbirth ": 3.74995180581302, "Strabismus ": 4.624468574170573, "Sudden death ": 6.505371193564982, "Suicidal behaviour ": 3.0178903355472477, "Suicidal ideation ": 2.011255180203694, "Supraventricular tachycardia ": 2.7166109327417987, "Thinking abnormal ": 3.1230174259871117, "Toxic epidermal necrolysis ": 7.452641959325338, "Transaminases increased ": 2.5258757767627587, "Urine odour abnormal ": 25.035341587166027, "Vasculitic rash ": 18.249286522458576, "Vomiting ": 3.5577108456382702} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1038.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1038.json new file mode 100644 index 00000000000..162e0bbe9e4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1038.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 4.482919413466625, "Dermatitis acneiform ": 109.56520027175364, "Diarrhoea ": 3.910977844504598, "Drug interaction ": 8.112214270459697, "International normalised ratio increased ": 8.283980724673425, "Interstitial lung disease ": 9.02994101022334, "Rash ": 3.1257014022538145} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1039.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1039.json new file mode 100644 index 00000000000..bd5cec427fc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1039.json @@ -0,0 +1 @@ +{"Abdominal tenderness ": 2.386699136694868, "Acute coronary syndrome ": 5.4828793947312695, "Acute lymphocytic leukaemia ": 7.485428183983045, "Acute myocardial infarction ": 6.659416816532057, "Alanine aminotransferase increased ": 3.008248203361484, "Amylase increased ": 17.283809620785814, "Anaemia ": 2.037020907871262, "Angina pectoris ": 6.4167786430618, "Angina unstable ": 5.935670670071813, "Angiopathy ": 8.542773693010151, "Anxiety ": 3.017489100464697, "Aortic aneurysm ": 2.6651883678180024, "Aortic arteriosclerosis ": 11.145538448411177, "Aortic stenosis ": 4.972108266025858, "Aplastic anaemia ": 2.09445202044265, "Arterial disorder ": 42.12464685714461, "Arterial occlusive disease ": 13.056470869488132, "Arterial stenosis ": 28.642650355179452, "Arterial thrombosis ": 5.013581101586812, "Arteriosclerosis ": 80.4653115628525, "Arteriosclerosis coronary artery ": 6.380077641824245, "Arteriospasm coronary ": 3.099875018838641, "Arteritis ": 16.57097312249361, "Aspartate aminotransferase increased ": 2.5276394109229448, "Atelectasis ": 2.1153497301608684, "Atrial fibrillation ": 3.4710419111827298, "Autoimmune thyroiditis ": 2.6203686052422857, "Benign prostatic hyperplasia ": 2.055103741290894, "Bilirubin conjugated increased ": 3.171598895672937, "Blast cell crisis ": 65.787395033958, "Blast crisis in myelogenous leukaemia ": 277.4737966803825, "Blood bilirubin increased ": 12.354251044771951, "Blood bilirubin unconjugated increased ": 16.73196857723267, "Bone marrow failure ": 8.899644590604984, "Bone pain ": 2.1865317160232878, "Brain natriuretic peptide increased ": 3.123549213064432, "Cardiac failure ": 2.7953130264371016, "Cardiac tamponade ": 4.113809368678278, "Cardiomegaly ": 2.980649541307642, "Carotid arteriosclerosis ": 34.89484449192835, "Carotid artery disease ": 12.284041145271209, "Carotid artery occlusion ": 12.77430639400956, "Carotid artery stenosis ": 73.38479983987187, "Cerebral artery occlusion ": 11.71336612691688, "Cerebral artery stenosis ": 77.25596773348751, "Cerebral infarction ": 8.42071961479401, "Cerebrovascular accident ": 3.744346334720356, "Cholecystitis acute ": 2.670496382121365, "Chronic myeloid leukaemia ": 172.46878921990853, "Chronic myeloid leukaemia recurrent ": 87.34681272528503, "Chronic myeloid leukaemia transformation ": 260.0588765360084, "Complex regional pain syndrome ": 5.617520289588552, "Concomitant disease aggravated ": 9.48085887258679, "Concomitant disease progression ": 13.895689962762471, "Coronary artery disease ": 11.219695878800598, "Coronary artery occlusion ": 10.821124267484125, "Coronary artery stenosis ": 15.07416756865447, "Cytogenetic analysis abnormal ": 104.52596741157228, "Cytopenia ": 7.478090340930419, "Death ": 2.1819640638041244, "Diabetes mellitus ": 5.095826424126925, "Diastolic dysfunction ": 4.368524650715163, "Drug resistance ": 2.747641535817559, "Dry skin ": 3.0863657914500533, "Dyslalia ": 6.119056515059161, "Dyslipidaemia ": 6.6961612187379895, "Electrocardiogram QT prolonged ": 12.345776215008677, "Emotional distress ": 7.998916420866814, "Essential hypertension ": 7.444960695895315, "Fluid retention ": 2.621310339943341, "Full blood count decreased ": 4.369976028996687, "Gamma-glutamyltransferase increased ": 2.2082758285107484, "Gangrene ": 13.01727473089618, "Gastrointestinal stromal tumour ": 5.131715129071721, "Gene mutation identification test positive ": 96.46885624299524, "Glucose tolerance impaired ": 3.8883943644847903, "Goitre ": 2.552399816687647, "Haematocrit decreased ": 2.5115994343114387, "Haematotoxicity ": 5.449363736664067, "Haemoglobin decreased ": 2.3349230606016635, "Hemiplegia ": 3.5214186186086374, "Hepatotoxicity ": 4.890901328588043, "Hyperbilirubinaemia ": 7.654302023865514, "Hypercholesterolaemia ": 9.74211879235081, "Hyperlipidaemia ": 7.029087789173481, "Hypertriglyceridaemia ": 2.075230482735936, "Infarction ": 5.2910010868976745, "Injury ": 20.58623093858763, "Intermittent claudication ": 138.1047019969824, "Intervertebral disc degeneration ": 2.514240863974114, "Intervertebral disc protrusion ": 2.0117182731620606, "Iron deficiency anaemia ": 3.205769918998977, "Ischaemia ": 7.443940733897348, "Ischaemic cardiomyopathy ": 4.209436227066488, "Ischaemic stroke ": 4.655592818252318, "Jaundice ": 2.3496068836225987, "Lactose intolerance ": 6.416781284253575, "Left ventricular dysfunction ": 2.668084826914534, "Left ventricular hypertrophy ": 6.120326506146673, "Leukaemia ": 2.1325683615721696, "Leukaemia recurrent ": 16.504493091168484, "Leukocytosis ": 4.133510356755458, "Lipase increased ": 32.00851409859394, "Liver disorder ": 2.637982610648082, "Liver function test increased ": 2.099874599126551, "Malignant neoplasm progression ": 4.4327934507756375, "Mitral valve incompetence ": 6.256271534798794, "Myelodysplastic syndrome ": 2.2255842714048435, "Myocardial infarction ": 4.50384630647375, "Myocardial ischaemia ": 8.118521790355238, "Nasal oedema ": 5.413016265413506, "Necrosis ": 5.092873782852443, "Oncologic complication ": 42.08369048026828, "Pancreatic enzymes increased ": 8.129112609753763, "Pancreatitis ": 8.25315426615855, "Pancreatitis acute ": 4.089603474774221, "Pancytopenia ": 6.349180443577289, "Papilloedema ": 2.919851787487163, "Paternal exposure during pregnancy ": 15.186235814275127, "Pericardial effusion ": 8.404129158562077, "Periorbital oedema ": 2.576622043072833, "Peripheral arterial occlusive disease ": 239.31663393931655, "Peripheral artery occlusion ": 55.40814471022747, "Peripheral artery stenosis ": 186.3985226001778, "Peripheral artery thrombosis ": 10.042240319792011, "Peripheral ischaemia ": 10.61232327409314, "Peripheral vascular disorder ": 25.99487833468264, "Philadelphia chromosome positive ": 41.05154737863561, "Platelet count decreased ": 4.234158264557448, "Platelet count increased ": 4.554988105601887, "Pleural effusion ": 7.861704993037496, "Pleurisy ": 2.5530031025859348, "Pulmonary hypertension ": 2.275815826709607, "Pulmonary oedema ": 2.149676524855153, "Renal artery stenosis ": 9.94674632921896, "Second primary malignancy ": 36.74854294651669, "Sensory loss ": 2.206685171643554, "Skin ulcer ": 2.8546315394564266, "Splenomegaly ": 4.732481892346645, "Stenosis ": 11.210949488634633, "Supraventricular extrasystoles ": 5.321136103174236, "Therapeutic response decreased ": 2.204898237344297, "Therapy non-responder ": 2.4665283458895737, "Thrombocytopenia ": 3.955956227145375, "Thrombocytosis ": 8.865542933185997, "Transaminases increased ": 2.4058786328694723, "Transient ischaemic attack ": 4.39126712203474, "Tricuspid valve incompetence ": 8.219420076582026, "Type 2 diabetes mellitus ": 2.289257638937851, "Ulcer ": 2.170221532082966, "Vascular occlusion ": 7.11349297118067, "Vascular stenosis ": 38.024486356969085, "Ventricular extrasystoles ": 2.034533105756093, "Vertebral artery stenosis ": 93.88610492639148, "White blood cell count increased ": 7.075524074978095} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/104.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/104.json new file mode 100644 index 00000000000..b492089504e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/104.json @@ -0,0 +1 @@ +{"Alanine aminotransferase abnormal ": 110.52070008424252, "Alanine aminotransferase increased ": 3.219699621697369, "Anal atresia ": 952.249070345796, "Anencephaly ": 784.0312787137402, "Aspartate aminotransferase abnormal ": 209.5312950032599, "Bladder agenesis ": 39404.1228813144, "Blood alkaline phosphatase increased ": 10.626364852276328, "Blood bilirubin increased ": 17.35154857583515, "Blood iron decreased ": 123.41799091410346, "Caudal regression syndrome ": 2636.088350718861, "Cholelithiasis ": 41.75148063711991, "Cloacal exstrophy ": 17988.291258625384, "Congenital anomaly ": 65.95198645740592, "Congenital ectopic bladder ": 5543.213819601852, "Congenital genital malformation ": 1569.8309245199737, "Congenital musculoskeletal disorder ": 547.0517563409115, "Congenital musculoskeletal disorder of spine ": 1140.4637512091592, "Drug-induced liver injury ": 6.756674975295933, "Erythema ": 2.762581063571254, "Exomphalos ": 901.5852294731764, "Exposure during pregnancy ": 5.743266026759097, "Fibrosis ": 124.22201749932825, "Foetal exposure during pregnancy ": 5.654519907981118, "Gastrointestinal disorder congenital ": 4701.065232172242, "Gastrointestinal malformation ": 1714.2496582015333, "Genitalia external ambiguous ": 3472.013490665753, "Hepatic cytolysis ": 10.8942409411567, "Hepatic enzyme increased ": 7.6700180362842625, "Hepatotoxicity ": 12.607378882023747, "Hypomania ": 58.1016134272866, "Jaundice ": 19.5686164861567, "Jaundice cholestatic ": 51.086931422449055, "Lipodystrophy acquired ": 313.1885069513086, "Pneumonia ": 3.698393232766496, "Premature labour ": 50.64353106010293, "Product use in unapproved indication ": 2.6650335679573085, "Psychotic disorder ": 9.227838194335083, "Schizophrenia ": 116.30765672503898, "Tinnitus ": 3.683780988840986, "Vomiting ": 2.333558757706116} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1040.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1040.json new file mode 100644 index 00000000000..f9dff1e1bb3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1040.json @@ -0,0 +1 @@ +{"Confusional state ": 5.669563911778029, "Dyskinesia ": 28.03310513943156} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1041.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1041.json new file mode 100644 index 00000000000..8a380b6bde5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1041.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 24.392855630902638, "Agranulocytosis ": 32.64999280948443, "Alopecia ": 15.24131808896068, "Breast cancer ": 2.3841679570405825, "Cardiac failure ": 3.704832408648704, "Diarrhoea ": 2.6104785225720466, "Febrile bone marrow aplasia ": 47.19696517020128, "Febrile neutropenia ": 10.331509711212863, "Flushing ": 3.3897819379479044, "Granulocytopenia ": 10.188942004006318, "Hepatic function abnormal ": 2.8702610770476173, "Interstitial lung disease ": 8.553226188585219, "Leukopenia ": 15.417388750327724, "Lung disorder ": 2.001515387755858, "Malignant neoplasm progression ": 2.4246877508444062, "Mucosal inflammation ": 10.3136214171609, "Myelosuppression ": 17.546431551703954, "Neuropathy peripheral ": 2.272630804462859, "Neutropenia ": 8.59562045425204, "Neutrophil count decreased ": 13.76337197432074, "Oedema ": 3.1204572923275715, "Palmar-plantar erythrodysaesthesia syndrome ": 4.153081478533539, "Pancytopenia ": 3.252733923666057, "Pleural effusion ": 2.617807302711724, "Pneumonitis ": 3.392565185806798, "Prostatic specific antigen increased ": 8.12737713949123, "Psychological trauma ": 231.20972511778865, "Sepsis ": 2.791674046342254, "Septic shock ": 4.0061911267247465, "Skin exfoliation ": 4.51448753622689, "Stomatitis ": 9.298416330429918, "White blood cell count decreased ": 15.763995605032802} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1042.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1042.json new file mode 100644 index 00000000000..a75cd539fa9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1042.json @@ -0,0 +1 @@ +{"Balance disorder ": 5.827939587163809, "Fall ": 3.620270209584692, "Flushing ": 13.435949972517502, "Gait disturbance ": 3.117955456330314, "Gastrointestinal disorder ": 2.9706934730808774, "Memory impairment ": 6.514345875131827, "Multiple sclerosis ": 46.771396749336944, "Multiple sclerosis relapse ": 48.757346912509696, "Muscle spasms ": 3.784136065385861, "Muscle spasticity ": 27.698310389422748, "Muscular weakness ": 2.5932401840977333, "Urinary tract disorder ": 83.19803877622537} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1043.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1043.json new file mode 100644 index 00000000000..572676df342 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1043.json @@ -0,0 +1 @@ +{"Drug resistance ": 254.29199408251824, "Off label use ": 23.720787754991523} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1044.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1044.json new file mode 100644 index 00000000000..ae58f67c4ea --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1044.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 5.1277662364354, "Abdominal distension ": 11.791425764328764, "Abdominal pain upper ": 2.1040598194208058, "Anxiety ": 2.4321796793193515, "Apathy ": 24.39302440109842, "Back pain ": 3.826840705334224, "Balance disorder ": 5.616529568335016, "Body temperature increased ": 3.9373600003290776, "Brain fog ": 23.49891729025513, "Compression fracture ": 119.8384336569958, "Contusion ": 4.422667764151881, "Cough ": 2.187113554942866, "Defaecation urgency ": 132.73646066353425, "Depressed level of consciousness ": 7.300647887370133, "Depression ": 2.2494264745268424, "Eructation ": 49.804557220690185, "Faeces hard ": 250.41818787072893, "Fall ": 2.483299481729722, "Feeding disorder ": 22.985848965815062, "Feeling abnormal ": 5.367405670299214, "Flatulence ": 24.45448797963413, "Frequent bowel movements ": 42.81589314851118, "Gastrointestinal stoma complication ": 831.550395288055, "Gastrointestinal stoma output abnormal ": 9578.639330348751, "Hiccups ": 52.586467848788864, "Hot flush ": 6.6337027206923445, "Hypersomnia ": 19.10133681389019, "Insomnia ": 2.7702106056602864, "Intestinal obstruction ": 49.144941412122165, "Joint swelling ": 4.895485853124828, "Lethargy ": 5.601716806197969, "Lumbar vertebral fracture ": 132.1628924135092} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1045.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1045.json new file mode 100644 index 00000000000..c3067556bf3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1045.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.595551872054118, "Fall ": 4.650298968905808} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1046.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1046.json new file mode 100644 index 00000000000..b9a7a393df3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1046.json @@ -0,0 +1 @@ +{"Anaemia ": 2.7779060769933666, "Cytopenia ": 19.408090829709096, "Decreased appetite ": 7.484137183796419, "Diarrhoea ": 2.6546182154293465, "Febrile neutropenia ": 2.600021384872554, "Gastrointestinal disorder ": 3.3255390937417397, "Granulocyte count decreased ": 35.40515316876338, "Haemoglobin decreased ": 6.601374361586855, "Interstitial lung disease ": 5.915587462163558, "Leukopenia ": 9.691648078360767, "Malignant neoplasm progression ": 2.341822028937473, "Myelosuppression ": 98.16820857735608, "Neuropathy peripheral ": 6.868056683700585, "Neutropenia ": 8.98674136639577, "Neutrophil count decreased ": 46.5933605454822, "Platelet count decreased ": 24.203811143532118, "Red blood cell count decreased ": 15.814446673867652, "Renal impairment ": 2.069044047804484, "Thrombocytopenia ": 5.371263958732753, "White blood cell count decreased ": 32.39378602539339} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1047.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1047.json new file mode 100644 index 00000000000..4c3eca71bf8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1047.json @@ -0,0 +1 @@ +{"Angioedema ": 4.852526923056708, "Blood creatinine increased ": 9.11414697954562, "Blood potassium increased ": 26.68296229833696, "Blood pressure inadequately controlled ": 143.43369787291007, "Blood pressure increased ": 8.85084234412658, "Cerebrovascular accident ": 2.6343060876584965, "Drug interaction ": 2.1225108539429067, "Hyperkalaemia ": 6.718978229010968, "Hypertension ": 4.070054403352931, "Palpitations ": 2.2555678102262497} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1048.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1048.json new file mode 100644 index 00000000000..3d84bfefe76 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1048.json @@ -0,0 +1 @@ +{"Anaemia ": 20.976499490462054, "Blood creatinine increased ": 20.323346852892215, "Drug interaction ": 15.697916934734002, "Pruritus ": 2.5581591849985323, "Rash ": 5.4578924914558415, "Thrombocytopenia ": 4.147390809311243} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1049.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1049.json new file mode 100644 index 00000000000..6a39b562412 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1049.json @@ -0,0 +1 @@ +{"Stevens-Johnson syndrome ": 235.45859548184885} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/105.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/105.json new file mode 100644 index 00000000000..d1e79fe7432 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/105.json @@ -0,0 +1 @@ +{"Abdominal distension ": 18.733780709178777, "Abdominal pain ": 4.990047295506409, "Actinic keratosis ": 3.2158832903036134, "Activated partial thromboplastin time prolonged ": 97.07337389774403, "Anaemia ": 8.111480776149696, "Analgesic therapy ": 1162.0121286805934, "Antacid therapy ": 4857.661048703754, "Anti-erythrocyte antibody ": 164.68195977219898, "Anti-erythropoietin antibody ": 63.4887630842544, "Anti-erythropoietin antibody negative ": 92.8942963410077, "Anti-erythropoietin antibody positive ": 190.2727245056481, "Antibody test positive ": 12.932783273162114, "Anticoagulant therapy ": 382.90548999125576, "Aortic arteriosclerosis ": 3.055648834068608, "Aortic stenosis ": 132.38306226231197, "Aortic valve incompetence ": 2.2528687802310547, "Aplasia pure red cell ": 171.87568015645115, "Aplastic anaemia ": 3.436135630868969, "Appendicitis ": 170.42240186197307, "Appendicolith ": 2225.6922003734244, "Arteriovenous fistula thrombosis ": 31.458975001674865, "Ascites ": 43.55920766000221, "Aspartate aminotransferase increased ": 4.0838081395885, "Aspiration ": 7.15716231469067, "Azotaemia ": 4.719695428709936, "Bacterial infection ": 77.4887290005829, "Bacteroides infection ": 2322.944841193785, "Blood calcium increased ": 9.826084718517018, "Blood cholesterol increased ": 20.11311616993462, "Blood parathyroid hormone increased ": 8.433325458690241, "Blood phosphorus increased ": 413.8302060432384, "Blood product transfusion dependent ": 25.08568241506981, "Blood test abnormal ": 8.900080268313706, "Blood uric acid increased ": 128.66668450380837, "Bone marrow disorder ": 5.484481087273288, "Bone marrow failure ": 11.299530211324427, "Bronchiectasis ": 10.711735328415182, "Calciphylaxis ": 6.873223493485576, "Cardiac output decreased ": 13.14843724982483, "Cardiogenic shock ": 90.56404506888036, "Carotid artery stenosis ": 3.039208306871444, "Caudal regression syndrome ": 38.94846739598081, "Chronic obstructive pulmonary disease ": 11.385967528329813, "Complications of transplanted kidney ": 22.16684485682795, "Condition aggravated ": 3.9780745604780954, "Constipation ": 9.739752824389711, "Death ": 8.113063000537679, "Delayed graft function ": 47.87820750073544, "Device difficult to use ": 32.496851461792616, "Diabetes mellitus ": 14.592634890733809, "Dialysis ": 59.39546002226727, "Diffuse alopecia ": 4.59568690268406, "Diverticulum intestinal ": 4.80085744929904, "Drug dose omission by device ": 4.725081980372287, "Drug hypersensitivity ": 8.809794231668283, "Drug intolerance ": 7.090382748370273, "Drug specific antibody ": 9.059478472726886, "Drug specific antibody absent ": 136.5510687603988, "Drug specific antibody present ": 10.780699717297322, "Drug therapy ": 712.9981526898817, "Dry mouth ": 6.034141166184418, "End stage renal disease ": 2.4100481030685983, "Erythropoiesis abnormal ": 36.462003295443765, "General physical health deterioration ": 11.250323339128803, "Haematocrit decreased ": 2.703816192310017, "Haemodialysis ": 117.31252584383982, "Haemoglobin abnormal ": 46.35016574269515, "Haemoglobin decreased ": 9.276834811757764, "Haemoglobin increased ": 15.465779206734448, "Hip fracture ": 2.906334527403862, "Hospitalisation ": 19.47206006717056, "Hyperparathyroidism ": 14.1125932972008, "Hyperparathyroidism secondary ": 13.352019944588278, "Hyperphosphataemia ": 323.6734064920491, "Hypervolaemia ": 3.3281553747046213, "Hyponatraemia ": 10.97572617095042, "Hypophosphataemia ": 62.26964528755798, "Incorrect route of product administration ": 15.691171974007732, "Injection site haemorrhage ": 3.259871913207012, "Intentional product misuse ": 4.96069783902575, "Iron deficiency ": 24.004628738543406, "Iron overload ": 11.939888168039078, "Kidney transplant rejection ": 5.013823535790412, "Laboratory test abnormal ": 2.792296422174614, "Multiple organ dysfunction syndrome ": 13.43277067963261, "Myelodysplastic syndrome ": 11.957347995660667, "Myelodysplastic syndrome with single lineage dysplasia ": 75.17752483159329, "Myelofibrosis ": 2.8832966867905294, "Neutralising antibodies positive ": 38.11223478447088, "Non-neutralising antibodies positive ": 396.30123387811545, "Normochromic normocytic anaemia ": 17.120467205408225, "Normocytic anaemia ": 3.0546007557742643, "Occult blood positive ": 2.7448656331196544, "Pancytopenia ": 2.021827558114906, "Parvovirus B19 infection ": 23.237744443252264, "Peritoneal dialysis ": 88.78259271561392, "Peritonitis ": 4.300743857641797, "Peritonitis bacterial ": 9.572433499343148, "Platelet count abnormal ": 3.3385415789168094, "Polycythaemia ": 3.3767239497890564, "Product storage error ": 3.653994517612783, "Red blood cell abnormality ": 8.72464495417338, "Rehabilitation therapy ": 7.602209643991872, "Renal disorder ": 2.015231458544135, "Renal transplant ": 44.59580225320743, "Reticulocyte count abnormal ": 193.21643531882725, "Reticulocyte count decreased ": 111.98983190628913, "Reticulocytopenia ": 66.72117700180749, "Sepsis ": 6.611824911750844, "Serum ferritin increased ": 4.796041499913586, "Splenomegaly ": 2.400867898159191, "Stress ": 14.698714259418422, "Supraventricular tachycardia ": 3.687987253926973, "Terminal state ": 12.19747309376526, "Therapeutic response decreased ": 18.615198280850112, "Therapy non-responder ": 3.1108143398791457, "Transfusion ": 14.3272725313101, "Transfusion reaction ": 25.49812255368961, "Transplant ": 72.57826578094708, "Transplant rejection ": 2.1254821356796505, "Unevaluable event ": 3.0465677840202483, "Urine odour abnormal ": 3.186975124658649, "Ventricular fibrillation ": 8.992294284558822, "Vitamin B12 deficiency ": 3.036715902304327} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1050.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1050.json new file mode 100644 index 00000000000..c54b7019afc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1050.json @@ -0,0 +1 @@ +{"Drug resistance ": 148.29231174476035, "Therapeutic response decreased ": 129.52114819956003} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1051.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1051.json new file mode 100644 index 00000000000..793366f9671 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1051.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 3.794996012364297, "Angioedema ": 7.017530788545577, "Asthma ": 2.969908944251255, "Atrioventricular block complete ": 5.830511208547697, "Autonomic neuropathy ": 85.42130020171288, "Blood creatine phosphokinase increased ": 3.496464806514477, "Blood creatinine increased ": 2.3743380964573357, "Blood pressure abnormal ": 4.590611781376902, "Blood pressure decreased ": 3.3554718293230743, "Blood pressure fluctuation ": 3.6105456277226993, "Blood pressure inadequately controlled ": 42.25598979425666, "Blood pressure increased ": 3.3168886646528093, "Blood pressure systolic increased ": 3.729874266038971, "Blood urea increased ": 3.140265540239677, "Bradycardia ": 4.090960621042076, "Cardio-respiratory arrest ": 4.826456496855538, "Chest discomfort ": 3.2618584404812383, "Clostridium difficile infection ": 6.492767959112053, "Clumsiness ": 44.01255712891343, "Cognitive disorder ": 3.492785374209239, "Cough ": 2.746860519454692, "Cranial nerve disorder ": 95.0725410915532, "Drug interaction ": 2.823500108073976, "Drug level increased ": 2.8350645496234783, "Drug reaction with eosinophilia and systemic symptoms ": 2.4107711183112275, "Electrocardiogram abnormal ": 4.918461170090918, "Encephalopathy ": 3.8846470810827474, "Forced expiratory flow decreased ": 2804.388150094649, "Forced vital capacity decreased ": 311.63286284412646, "Full blood count abnormal ": 5.310903785908307, "Giant cell arteritis ": 34.0285107602632, "Heart rate decreased ": 5.281758681616276, "Hypercalcaemia ": 8.75568038213015, "Hyperkalaemia ": 10.287335806164004, "Hypertensive crisis ": 5.356696146564699, "Hypokalaemia ": 2.273463676710508, "Hyponatraemia ": 4.158363038635899, "Hypotension ": 3.092812003639183, "Illness ": 2.153865259770189, "Jaw disorder ": 47.529180325284045, "Left ventricular hypertrophy ": 12.13198423660111, "Loss of personal independence in daily activities ": 4.800037831736784, "Meningitis aseptic ": 12.6570295587455, "Mononeuropathy multiplex ": 120.48405403877672, "Myelitis ": 29.142288020288525, "Nasopharyngitis ": 4.014674871096902, "Oedema peripheral ": 3.0004241882566376, "Oligohydramnios ": 27.02468754792876, "Oliguria ": 5.370400027937494, "Optic neuropathy ": 42.39028228996898, "Oral discomfort ": 5.600585268935812, "Orthostatic hypotension ": 7.027951063427358, "Peripheral sensorimotor neuropathy ": 69.99693825383892, "Peripheral sensory neuropathy ": 15.417019349574757, "Product substitution issue ": 20.64133703091313, "Product use issue ": 3.771594390572568, "Prolonged expiration ": 84.50497864567333, "Proteinuria ": 2.89361043441058, "Pyelonephritis ": 6.255679723179492, "Red blood cell sedimentation rate increased ": 9.898958802959395, "Rhabdomyolysis ": 2.479783272090896, "SARS-CoV-2 test positive ": 3.7698750474433584, "Schizophrenia ": 6.0018915112044855, "Shock ": 3.060508605316859, "Sjogren's syndrome ": 26.32475250699679, "Sleep disorder due to a general medical condition ": 19.626837093032712, "Small fibre neuropathy ": 52.36215712988933, "Therapeutic product effect incomplete ": 5.949670181101318, "Thirst ": 2.6013816464191817, "Toxic epidermal necrolysis ": 2.0374826664606847, "Toxicity to various agents ": 2.565865072581975, "Wheezing ": 5.55756358154325} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1052.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1052.json new file mode 100644 index 00000000000..e6b3c364345 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1052.json @@ -0,0 +1 @@ +{"Accidental overdose ": 2.02270447511109, "Acute myeloid leukaemia ": 4.699236292442226, "Adverse event ": 5.161614581684264, "Agranulocytosis ": 6.893313513070406, "Anaemia ": 2.9944080670356383, "Aphasia ": 2.680491570203874, "Aplastic anaemia ": 15.672726238864222, "Bone marrow failure ": 75.61106524175345, "Brain oedema ": 14.23319789792493, "Cerebral haemorrhage ": 3.040842909308634, "Cholestasis ": 10.202963317414216, "Congenital aplasia ": 35.36698485813653, "Cytomegalovirus infection ": 3.5366449631525554, "Cytopenia ": 6.196162914729093, "Death ": 2.3231587938627483, "Disease progression ": 14.270617859201955, "Disseminated intravascular coagulation ": 4.195681272520557, "Drug eruption ": 4.61005253150852, "Dysphagia ": 3.610513347028712, "Eastern Cooperative Oncology Group performance status worsened ": 65.32830794778262, "Eosinophilia ": 2.0849875804530624, "Epilepsy ": 2.535265624932308, "Erythema multiforme ": 2.1841383531529224, "Febrile bone marrow aplasia ": 61.73465827641543, "Febrile neutropenia ": 4.230445632688407, "Gamma-glutamyltransferase increased ": 3.190926144679189, "Gingival bleeding ": 2.84944494231234, "Glioblastoma ": 118.01532593067084, "Glioblastoma multiforme ": 115.32368295869314, "Haematotoxicity ": 6.996148203447115, "Haemolytic anaemia ": 3.4656108183205223, "Haemorrhage intracranial ": 2.6311387453592663, "Hemiparesis ": 4.2291840001044765, "Hemiplegia ": 7.010506398444517, "Hepatic cytolysis ": 11.07514157520685, "Hepatic function abnormal ": 4.416454579961031, "Hepatocellular injury ": 6.302324232807426, "Hepatotoxicity ": 3.124515286193175, "Interstitial lung disease ": 2.038499602830289, "Intracranial pressure increased ": 8.991560477816442, "Intracranial tumour haemorrhage ": 190.82067344463024, "Jaundice ": 2.058926014751334, "Leukoencephalopathy ": 12.403514266290706, "Leukopenia ": 13.310108986627728, "Liver disorder ": 2.0105244928308434, "Liver injury ": 2.0623628003677035, "Lymphocyte count decreased ": 23.103146852237835, "Lymphopenia ": 16.68107467108862, "Malignant neoplasm progression ": 3.859162467647848, "Mucosal inflammation ": 2.402037579790392, "Multiple organ dysfunction syndrome ": 2.083632835555644, "Myelodysplastic syndrome ": 6.272516643396435, "Myelosuppression ": 8.264221843129564, "Neoplasm progression ": 3.2329657185116214, "Neutropenia ": 8.203848027971022, "Neutrophil count decreased ": 3.685588854368564, "Pancytopenia ": 30.691148650726, "Petechiae ": 4.8169906168205685, "Platelet count decreased ": 6.739882994195853, "Platelet transfusion ": 56.87757181459276, "Pneumocystis jirovecii infection ": 55.0193527045579, "Pneumocystis jirovecii pneumonia ": 30.5036585333217, "Pneumonia ": 2.4987930683595594, "Pneumonia aspiration ": 2.517192178676251, "Pulmonary embolism ": 3.8037498622127535, "Purpura ": 4.512247378692203, "Rash maculo-papular ": 2.7870709919448804, "Recurrent cancer ": 24.556628805135485, "Seizure ": 2.1061033414766097, "Sepsis ": 6.076095993819735, "Septic shock ": 2.1913939740298494, "Stevens-Johnson syndrome ": 7.510492167622416, "Surgery ": 2.435043475799687, "Thrombocytopenia ": 22.98093250697276, "Toxic epidermal necrolysis ": 4.9508593319439935, "Toxic skin eruption ": 5.32718600065986, "White blood cell count decreased ": 4.699609438640698} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1053.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1053.json new file mode 100644 index 00000000000..0fae0cd665f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1053.json @@ -0,0 +1 @@ +{"Thrombocytopenia ": 34.07156698320266} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1054.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1054.json new file mode 100644 index 00000000000..2f085c41b67 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1054.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 16.04641485252656, "Anaemia ": 2.21703539339331, "Aphasia ": 3.804293192407808, "Aplastic anaemia ": 42.15746161684291, "Astrocytoma ": 134.65670303122215, "Astrocytoma malignant ": 857.1310857801292, "Astrocytoma, low grade ": 470.633906066964, "Bone marrow failure ": 22.866841213880523, "Brain oedema ": 9.21045529819666, "Cholestasis ": 3.2985823658421487, "Cytopenia ": 4.797980290171688, "Dermatitis ": 3.529005135167269, "Diabetes insipidus ": 61.41906402176815, "Disease progression ": 16.15421356856522, "Disease recurrence ": 13.053283133201347, "Drug ineffective ": 2.21117844941391, "Drug reaction with eosinophilia and systemic symptoms ": 4.738067750484578, "Drug resistance ": 6.000159797207004, "Drug-induced liver injury ": 2.7360758674578536, "Eastern Cooperative Oncology Group performance status worsened ": 187.3886423931176, "Febrile neutropenia ": 5.276576310830276, "Glioblastoma ": 355.40828063677634, "Glioblastoma multiforme ": 250.3005974242701, "Haematotoxicity ": 55.01334121756218, "Hemiparesis ": 7.634211518217326, "Hepatic failure ": 2.3241201067759727, "Hepatotoxicity ": 3.594665722255572, "Hydrocephalus ": 16.113104648133792, "Hypermutation ": 3989.270212284088, "Hypertransaminasaemia ": 7.499914540658484, "Infection ": 2.4208713724480457, "Jaundice ": 2.7341669762548224, "Leukopenia ": 10.172920643292162, "Liver injury ": 2.825557141379093, "Lymphopenia ": 66.75238665159297, "Malignant neoplasm progression ": 9.587188952169704, "Metastasis ": 11.842009849091328, "Mucosal inflammation ": 3.8913693932643, "Myelodysplastic syndrome ": 32.27090725212073, "Myelosuppression ": 8.396614169605277, "Neoplasm progression ": 10.827016044707758, "Neutropenia ": 9.27793081950365, "Pancytopenia ": 20.55017296647523, "Petechiae ": 3.127501591806748, "Platelet count decreased ": 2.332553895473639, "Platelet transfusion ": 80.54199615150993, "Pneumocystis jirovecii pneumonia ": 17.669069548919932, "Product substitution issue ": 2.75563338050983, "Product use in unapproved indication ": 3.586037708834336, "Recurrent cancer ": 27.349213887157944, "Seizure ": 2.1612008364529225, "Sepsis ": 2.5116269997016007, "Skin reaction ": 3.122019542635341, "Therapeutic product effect incomplete ": 2.276155543131332, "Thrombocytopenia ": 26.29024978772875, "Toxicity to various agents ": 2.4373725895555034, "Treatment failure ": 2.35476778226406, "Tumour pseudoprogression ": 488.9504675403912, "Vanishing bile duct syndrome ": 133.89355413218908} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1055.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1055.json new file mode 100644 index 00000000000..8066cea6ef6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1055.json @@ -0,0 +1 @@ +{"Anaemia ": 3.950644018200796, "Colitis ": 10.273485339860294, "Dehydration ": 4.06251538057722, "Disease progression ": 7.072765354782429, "Febrile neutropenia ": 29.09691853793297, "Hypertriglyceridaemia ": 37.08302601852363, "Interstitial lung disease ": 5.73365439118869, "Mucosal inflammation ": 15.267585899345825, "Myocardial infarction ": 4.519647519580414, "Neutropenia ": 7.260834303941766, "Neutrophil count decreased ": 6.668299049757854, "Overdose ": 4.736074388706919, "Pneumonia ": 3.099061957816612, "Pneumonitis ": 26.033960533213502, "Stomatitis ": 47.4149557735368, "Thrombocytopenia ": 2.715561165654413, "White blood cell count decreased ": 2.618507955041384} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1056.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1056.json new file mode 100644 index 00000000000..26693758a79 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1056.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 5.417591513078398, "Alanine aminotransferase increased ": 4.80622794631563, "Aspartate aminotransferase increased ": 2.6535811939677347, "Blood alkaline phosphatase increased ": 2.867471441805755, "Blood bicarbonate decreased ": 55.16388215135517, "Blood creatine phosphokinase increased ": 4.284897958206766, "Blood creatinine increased ": 9.830290059793509, "Blood phosphorus decreased ": 85.43367228710261, "Blood urea increased ": 8.805888805590932, "Bone pain ": 4.274348497211423, "Chronic hepatitis B ": 389.0990288891209, "Chronic kidney disease ": 14.40170331232908, "Drug ineffective ": 2.027207051663556, "Drug resistance ": 12.66793728472928, "Drug-induced liver injury ": 2.310163478860713, "Fanconi syndrome ": 270.4801030760049, "Fanconi syndrome acquired ": 274.5703555001742, "Femur fracture ": 9.745262188288708, "Foetal exposure during pregnancy ": 3.4396858486596025, "Glomerular filtration rate decreased ": 26.25382620265648, "Glycosuria ": 208.0560519742387, "Hepatitis B ": 66.05944286504219, "Hepatitis B DNA increased ": 193.33614043315708, "Hepatitis B reactivation ": 90.9693594286036, "Hypokalaemia ": 4.552127168458829, "Hypophosphataemia ": 127.26828519478757, "Hypophosphataemic osteomalacia ": 846.721781779316, "Immune reconstitution inflammatory syndrome ": 12.867663194107063, "Lactic acidosis ": 3.481036080947576, "Maternal exposure during pregnancy ": 6.16179687642922, "Metabolic acidosis ": 15.265377300721712, "Multiple organ dysfunction syndrome ": 2.5388572546855173, "Nephrogenic diabetes insipidus ": 40.97437493593878, "Nephropathy toxic ": 36.3441495212082, "Osteomalacia ": 99.17814845409876, "Osteopenia ": 5.189291991228509, "Osteoporosis ": 8.634721512900589, "Proteinuria ": 24.1606279256998, "Rebound effect ": 118.93981745434986, "Renal failure ": 3.5900369824311653, "Renal impairment ": 13.01960026871292, "Renal tubular acidosis ": 160.38798791436352, "Renal tubular disorder ": 435.4851892212097, "Renal tubular dysfunction ": 371.5404758912924, "Renal tubular necrosis ": 22.580582914456304, "Treatment noncompliance ": 7.879381013301568, "Tubulointerstitial nephritis ": 5.814511798411333, "Viral load increased ": 51.89174899445597} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1057.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1057.json new file mode 100644 index 00000000000..89904063e63 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1057.json @@ -0,0 +1 @@ +{"Acute graft versus host disease ": 465.04008749833, "Graft versus host disease ": 383.9366784620941, "Mucosal inflammation ": 61.453650752156} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1058.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1058.json new file mode 100644 index 00000000000..42da1e37cb7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1058.json @@ -0,0 +1 @@ +{"Nausea ": 3.538019223047813} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1059.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1059.json new file mode 100644 index 00000000000..ac7029c3bfc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1059.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 2.27424550433732, "Alopecia ": 5.218457105556481, "Back pain ": 2.35408132758621, "Balance disorder ": 4.788713031039936, "Depressed mood ": 3.6773538294595913, "Fall ": 3.4592618735233875, "Gait disturbance ": 3.353421973267857, "Hepatic enzyme increased ": 3.7271520613998126, "Hypoaesthesia ": 3.1773718405128504, "Memory impairment ": 3.1825561538104483, "Multiple sclerosis ": 35.87273619557571, "Multiple sclerosis relapse ": 74.31171249524328, "Product substitution issue ": 14.914393889373814, "Unevaluable event ": 7.398559640031065, "Urinary tract infection ": 3.0511830535556634} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/106.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/106.json new file mode 100644 index 00000000000..b7e7dff2070 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/106.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 14.712932504523572, "Acanthosis ": 3.689549793530921, "Adjustment disorder with depressed mood ": 3.5715944422090926, "Adverse drug reaction ": 4.650861613686885, "Adverse event ": 3.3333180071501625, "Alanine aminotransferase abnormal ": 2.7256640428272503, "Allergic oedema ": 2.971992854367356, "Allergy to chemicals ": 6.724996482387304, "Alopecia ": 12.54852227596196, "Anaemia of chronic disease ": 3.9938957372538497, "Anal abscess ": 4.494408690296324, "Ankle deformity ": 15.334795269142532, "Ankle operation ": 2.4790450462881704, "Ankylosing spondylitis ": 2.2825634434356075, "Anti-cyclic citrullinated peptide antibody ": 2.753592127250601, "Anti-cyclic citrullinated peptide antibody positive ": 37.69426586849564, "Aortic bruit ": 13.803300886070748, "Appetite disorder ": 3.723861259266066, "Arthritis ": 2.601940896681242, "Arthritis infective ": 7.513313708904587, "Arthrodesis ": 8.73150413354774, "Arthropathy ": 25.81598372032629, "Aspartate aminotransferase ": 2.4766295204909543, "Autoimmune disorder ": 4.1218174645105154, "Back injury ": 5.941411951629891, "Basal cell carcinoma ": 2.1385786500683297, "Benign neoplasm ": 4.60588286202586, "Bladder operation ": 2.812469797532208, "Blister ": 5.228731849232858, "Blood cholesterol increased ": 7.327596191638046, "Blood immunoglobulin A decreased ": 2.179550263868893, "Blood immunoglobulin M increased ": 2.2861965629979397, "Blood iron abnormal ": 127.69965101505848, "Blood magnesium increased ": 9.490800288893864, "Blood parathyroid hormone decreased ": 7.5213671382287615, "Blood pressure diastolic abnormal ": 2.4242869596020173, "Blood pressure systolic abnormal ": 2.3735426771780355, "Bloody discharge ": 3.166956466825836, "Bone cyst ": 23.247899823677518, "Bone deformity ": 2.6304053565746464, "Bone erosion ": 29.95929272242476, "Bone graft ": 9.212926098114693, "Bone swelling ": 11.271256090841714, "Breast cancer stage II ": 2.031472754369356, "Breast cancer stage III ": 3.725126325368865, "Breast prosthesis user ": 34.65529341395296, "Bunion operation ": 55.15942871392636, "Bursitis ": 4.767716444208414, "Bursitis infective ": 6.5922797978762935, "C-reactive protein ": 11.950270559436058, "C-reactive protein abnormal ": 19.30095736263544, "C-reactive protein decreased ": 2.989895740836226, "C-reactive protein increased ": 3.0563512391167804, "Carbon dioxide abnormal ": 15.242397456482294, "Carbon dioxide decreased ": 4.879140844356236, "Chondropathy ": 4.359100504768151, "Coeliac disease ": 2.782860756321908, "Colitis microscopic ": 3.3629362434143157, "Condition aggravated ": 3.77624779827956, "Congenital anomaly ": 11.893907068626804, "Contraindicated product administered ": 32.50095198601979, "Contraindicated product prescribed ": 3.093960960985429, "Contraindication to vaccination ": 4.170106012900478, "Contrast media allergy ": 2.624520251869501, "Contusion ": 3.29227130298331, "Crepitations ": 2.949842769296088, "Cytology abnormal ": 9.794604072561938, "Deafness transitory ": 11.25520099102776, "Deep vein thrombosis postoperative ": 14.772646574690947, "Deformity ": 4.822640778587149, "Dermatitis psoriasiform ": 3.6592529912643257, "Discomfort ": 12.537173983712538, "Disease susceptibility ": 4.002971819270885, "Dislocation of vertebra ": 2.1452598055171865, "Drug hypersensitivity ": 6.205757257189551, "Drug ineffective ": 3.796937229504866, "Drug intolerance ": 14.61619281106328, "Drug tolerance ": 2.11645187883455, "Drug tolerance decreased ": 22.93940708484903, "Duodenal ulcer perforation ": 34.065418763154184, "Dysphoria ": 2.379511087341074, "Ear pain ": 5.567050791520222, "Elbow deformity ": 9.311176102348565, "Elbow operation ": 6.080852419362097, "Encephalitis brain stem ": 3.7569711732721247, "Endocrine ophthalmopathy ": 6.369846722976291, "Epigastric discomfort ": 2.0426927597005764, "Exostosis ": 13.483575248992612, "Extremity contracture ": 4.12261672161392, "Eyelid disorder ": 2.7803840561812248, "Facet joint syndrome ": 7.414104810804019, "Fibromyalgia ": 4.219813130426774, "Fine motor skill dysfunction ": 5.173450313585176, "Finger deformity ": 11.55157223123226, "Folliculitis ": 13.90153789143132, "Foot deformity ": 13.215457919014629, "Foot operation ": 7.043414607298327, "Functional gastrointestinal disorder ": 2.3804125527506703, "Gait inability ": 2.2396155511784417, "Gastroenteritis salmonella ": 2.3186112870267075, "Gastrointestinal disorder ": 4.319061886164499, "Gastrointestinal toxicity ": 11.267506862881076, "General physical health deterioration ": 3.724061040242344, "Glossodynia ": 47.29144898429404, "Granuloma skin ": 9.644300144015356, "Granulomatous dermatitis ": 4.924562288271879, "Grip strength decreased ": 3.094889078082489, "Haemodilution ": 15.3284034178499, "Haemorrhagic diathesis ": 4.07947572293086, "Hand deformity ": 57.71582471304931, "Helicobacter infection ": 31.054248932287692, "Hepatic enzyme increased ": 8.841971590008157, "Hepatic fibrosis ": 2.2515180600756315, "Hepatic haematoma ": 6.094181489152541, "Hepatic steatosis ": 2.3329643479107456, "Hepatitis B core antibody positive ": 4.632450185080048, "Hepatotoxicity ": 2.7113613139895683, "Hip arthroplasty ": 16.904942103738954, "Hip deformity ": 4.3920892718757925, "Histiocytosis ": 11.067650723711097, "Hunger ": 4.2383840352292, "Hypercholesterolaemia ": 4.321248847843233, "Hypermobility syndrome ": 6.647557261094192, "Hypersensitivity ": 4.387726764830991, "Ill-defined disorder ": 5.669340981066956, "Immobile ": 4.2106916915654615, "Impaired healing ": 9.776260801158914, "Infection ": 4.30173791377368, "Infusion related reaction ": 14.73064050774406, "Intentional product use issue ": 2.847906255774537, "Interferon gamma release assay positive ": 16.758174057839074, "Intervertebral disc compression ": 14.617737341870194, "Intervertebral disc space narrowing ": 20.58020249263744, "Intestinal polyp ": 3.0837720061716, "Investigation abnormal ": 5.911467402154835, "Irritable bowel syndrome ": 7.768570336147479, "Joint ankylosis ": 8.046287844131554, "Joint arthroplasty ": 4.161442644088457, "Joint dislocation ": 5.753712258838939, "Joint injury ": 4.748705729083529, "Joint laxity ": 5.151766884011396, "Joint lock ": 3.154680827114403, "Joint range of motion decreased ": 3.7405211176097497, "Joint space narrowing ": 3.845334368217507, "Joint stiffness ": 6.916842347449433, "Joint surgery ": 11.199576096141415, "Joint swelling ": 14.254563836023484, "Keratitis ": 2.0890813479578694, "Kidney infection ": 3.107948667693437, "Knee arthroplasty ": 18.66581368085681, "Labile blood pressure ": 2.131296654253137, "Laryngeal disorder ": 12.69420637316792, "Laryngitis ": 2.9137284949269024, "Limb deformity ": 8.839749034402201, "Limb operation ": 2.578357070322252, "Lip ulceration ": 3.502370454611716, "Live birth ": 6.834261988394675, "Liver function test increased ": 2.9102686130140705, "Liver injury ": 6.35759750154798, "Localised infection ": 2.3168242017485885, "Loose body in joint ": 4.246605494391295, "Loss of employment ": 6.622548449023761, "Loss of personal independence in daily activities ": 3.597968762727217, "Lower limb fracture ": 2.5712653021751777, "Lower respiratory tract infection ": 8.20569673439919, "Lupus vulgaris ": 2.104030994476698, "Lupus-like syndrome ": 2.16926106935813, "Lymphocyte count increased ": 2.9050355953365687, "Maculopathy ": 2.0988054650031627, "Maternal exposure before pregnancy ": 2.7943857226769566, "Maternal exposure during pregnancy ": 10.60486212078613, "Mean cell haemoglobin increased ": 6.95476286059655, "Medical device implantation ": 2.991779229381196, "Microcytic anaemia ": 2.0069486068144857, "Mobility decreased ": 2.566890644372059, "Morphoea ": 2.9813486577318904, "Multiple allergies ": 2.307347809628296, "Muscle injury ": 11.258973495805348, "Muscle spasticity ": 21.042189494675814, "Musculoskeletal disorder ": 5.053214500409497, "Musculoskeletal pain ": 4.061352684228294, "Musculoskeletal stiffness ": 6.168357153468685, "Mycobacterium tuberculosis complex test positive ": 4.447792284993893, "Nail disorder ": 2.6396625440550934, "Nail operation ": 7.458853867128867, "Nasal ulcer ": 6.783110762184133, "Neck deformity ": 17.007863968389056, "Nephrolithiasis ": 2.431805185606731, "Nerve injury ": 3.5035650715671265, "Night sweats ": 4.958419837141051, "Non-Hodgkin's lymphoma ": 5.497199970593192, "Ocular toxicity ": 3.661620326929036, "Onycholysis ": 3.859474178586268, "Osteoarthritis ": 4.000949170567793, "Osteolysis ": 5.403231900069628, "Osteosclerosis ": 4.079493885432548, "Ovarian neoplasm ": 3.824492475410161, "Pain ": 3.2036804497545424, "Panniculitis ": 2.265618622220262, "Pemphigus ": 98.96507651564156, "Pericarditis ": 9.89118039729899, "Peripheral swelling ": 2.933660418066702, "Pleural fibrosis ": 5.866102604500076, "Pleural thickening ": 4.670280547142492, "Pneumonia cryptococcal ": 2.830334034410101, "Pneumonia viral ": 2.528507992149643, "Presbyacusis ": 9.149546053071983, "Prescribed underdose ": 3.5587368366656547, "Product label confusion ": 9.402989570418708, "Product use issue ": 7.411772078949007, "Pruritus allergic ": 2.804497435681925, "Psoriatic arthropathy ": 9.548644909845526, "Pulmonary congestion ": 3.164545355822763, "Pulmonary fibrosis ": 2.688814806170543, "Pulmonary mass ": 2.4991775845595097, "Pulmonary toxicity ": 8.333499679342365, "Pustular psoriasis ": 2.681373680423466, "Red blood cell sedimentation rate abnormal ": 21.83408710047699, "Red blood cell sedimentation rate increased ": 5.355280711869139, "Red cell distribution width increased ": 2.0390654708420626, "Respiratory disorder ": 6.309106340480904, "Respiratory tract congestion ": 6.739448029026648, "Respiratory tract infection viral ": 2.4298096508246583, "Rheumatic fever ": 31.35657492616648, "Rheumatoid arthritis ": 26.075039105980768, "Rheumatoid factor increased ": 2.882240675672327, "Rheumatoid factor negative ": 54.05435480938698, "Rheumatoid factor positive ": 57.678731259422975, "Rheumatoid lung ": 7.327843084994484, "Rheumatoid nodule ": 34.11991791423619, "Sciatica ": 2.775598812585476, "Sensitivity to weather change ": 2.342490154516256, "Seronegative arthritis ": 7.056097733713079, "Shoulder arthroplasty ": 4.2930570824520204, "Sinusitis ": 5.587221436968477, "Sjogren's syndrome ": 4.2873256399977535, "Skin ulcer ": 2.360997450507514, "Skin warm ": 2.835876712100337, "Sleep disorder due to general medical condition, insomnia type ": 6.351568711870869, "Soft tissue disorder ": 8.016844953796777, "Soft tissue swelling ": 5.49261517478714, "Stomatitis ": 2.098328157452735, "Stress at work ": 4.354303970139391, "Surgical failure ": 4.603269345261382, "Swelling ": 10.424636986412722, "Swollen joint count increased ": 49.96763288366297, "Synovial cyst ": 3.8386537542175647, "Synovial disorder ": 2.495526998722089, "Synovitis ": 41.80207348107168, "Systemic lupus erythematosus ": 50.23340268059884, "Systemic lupus erythematosus rash ": 47.50591294671756, "Tenosynovitis ": 7.702459631349291, "Therapeutic product effect decreased ": 11.316951978945765, "Therapeutic product effect incomplete ": 3.1106026350342577, "Therapy non-responder ": 2.251893454637893, "Thyroid neoplasm ": 9.98092848928448, "Tonsillar disorder ": 2.312648863525, "Tooth disorder ": 3.683164970564284, "Tooth infection ": 8.292598575101, "Transplant dysfunction ": 2.799759743348389, "Treatment failure ": 12.305580702433332, "Tuberculin test positive ": 15.27054461304094, "Type 2 diabetes mellitus ": 4.928721738995066, "Vaginal haematoma ": 32.71066964142666, "Viral upper respiratory tract infection ": 2.532275251851558, "White blood cell count abnormal ": 14.849201187849102, "Wound ": 42.467593812004566, "Wrist deformity ": 7.603789562738561, "Wrist surgery ": 7.659929583161888, "X-ray abnormal ": 6.262361852890722} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1060.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1060.json new file mode 100644 index 00000000000..1ff4cdd95cc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1060.json @@ -0,0 +1 @@ +{"Back pain ": 3.2535292471658583, "Bone pain ": 4.1287137660365465, "Calciphylaxis ": 159.30080992833138, "Fall ": 5.765573187401218, "Femur fracture ": 16.10478800098519, "Hip fracture ": 15.484716274988267, "Hospitalisation ": 2.0386633959000635, "Hypercalcaemia ": 76.67013068304536, "Muscle spasms ": 2.469262203061878, "Nephrolithiasis ": 6.1441501362115165, "Renal impairment ": 2.354725013778273, "Skin necrosis ": 19.31323140631608, "Spinal compression fracture ": 18.35043349921976, "Spinal fracture ": 13.013928960845346, "Upper limb fracture ": 19.51463055554854} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1061.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1061.json new file mode 100644 index 00000000000..fbbf368b05a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1061.json @@ -0,0 +1 @@ +{"Back pain ": 4.502696978429284, "Bone pain ": 6.888177846802693, "Device malfunction ": 17.42239485942071, "Dizziness ": 2.975380818238293, "Injection site bruising ": 42.52910538142604, "Injection site erythema ": 4.430756947462962, "Injection site haemorrhage ": 26.57497786214627, "Muscle spasms ": 3.495796094787281, "Nausea ": 2.087142972732305, "Pain in extremity ": 2.738348488732794, "Palpitations ": 3.018722676984012, "Product dose omission issue ": 5.198305610758029, "Therapy interrupted ": 62.73146371117658, "Wrong technique in device usage process ": 44.20027338226655} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1062.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1062.json new file mode 100644 index 00000000000..43fa818ce3a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1062.json @@ -0,0 +1 @@ +{"Accidental exposure to product ": 12.133928462726663, "Acne ": 9.482122962005262, "Acute myocardial infarction ": 17.65475484534197, "Aggression ": 4.5183831739044376, "Anger ": 5.4076833385033, "Angina pectoris ": 2.9020354193847595, "Aortic aneurysm ": 18.258745645855708, "Arteriosclerosis ": 10.723714771519749, "Atrial fibrillation ": 2.0124080333086325, "Blood testosterone decreased ": 86.29151750289886, "Blood testosterone increased ": 402.4808588251767, "Bone disorder ": 7.145259602703311, "Breast cancer ": 3.90925065961056, "Breast cancer metastatic ": 8.942166329506405, "Cardiac death ": 99.10206935253902, "Cardiac failure congestive ": 2.182295636042926, "Cardiomyopathy ": 7.394616815611124, "Cerebrovascular accident ": 4.358027315645759, "Cholestasis ": 3.115088246584666, "Coronary artery disease ": 11.698049165440857, "Coronary artery occlusion ": 6.878589948916703, "Deep vein thrombosis ": 15.49091109553344, "Device dislocation ": 34.210530559679896, "Device malfunction ": 6.05952459091586, "Drug abuse ": 12.984058523005102, "Drug-induced liver injury ": 2.5714357885909904, "Dyslipidaemia ": 9.428058377200806, "Endometrial cancer ": 45.82588833505356, "Erectile dysfunction ": 5.861588361794704, "Gynaecomastia ": 7.1351328836930366, "Hair growth abnormal ": 28.50880331471912, "Idiopathic intracranial hypertension ": 65.82142776256607, "Intentional product misuse ": 3.0541380412068246, "Invasive ductal breast carcinoma ": 17.47619105370686, "Jaundice ": 3.0896299929626605, "Left ventricular hypertrophy ": 46.62225786585368, "Libido decreased ": 7.07597971587408, "Mesenteric vein thrombosis ": 50.04406637958645, "Muscle mass ": 195.39051143952344, "Myocardial fibrosis ": 92.16453514520332, "Myocardial infarction ": 4.311761855990994, "Obstructive sleep apnoea syndrome ": 27.36125663288645, "Oestradiol increased ": 182.0430068416356, "Off label use ": 2.642928006776543, "Osteonecrosis ": 3.1980220199220595, "Papilloedema ": 18.204226209297303, "Polycythaemia ": 194.5021391228964, "Portal vein thrombosis ": 23.015678258440865, "Precocious puberty ": 180.70576479241248, "Prescription drug used without a prescription ": 22.69348618358044, "Product quality issue ": 13.9082561483666, "Product use in unapproved indication ": 2.8725928222521997, "Product use issue ": 7.260814834947145, "Prostate cancer ": 6.712579923483899, "Prostatic specific antigen increased ": 10.009669084425653, "Pulmonary embolism ": 8.985918267734501, "Self-medication ": 59.12310105212452, "Testicular atrophy ": 131.1330952288465, "Therapeutic product effect decreased ": 2.223839866377145, "Thrombosis ": 2.770689065908854, "Transgender hormonal therapy ": 3987.402969464821, "Virilism ": 929.6762637530966} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1063.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1063.json new file mode 100644 index 00000000000..a5ee27d83c3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1063.json @@ -0,0 +1 @@ +{"Bone pain ": 27.846789229238368, "Drug ineffective ": 7.129563425841416, "Erythema ": 6.3232184249857255} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1064.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1064.json new file mode 100644 index 00000000000..1543e106a29 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1064.json @@ -0,0 +1 @@ +{"Product use in unapproved indication ": 20.18888135059103} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1065.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1065.json new file mode 100644 index 00000000000..4f47e42f72e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1065.json @@ -0,0 +1 @@ +{"Asthma ": 32.77069085038518} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1066.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1066.json new file mode 100644 index 00000000000..d40549a8033 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1066.json @@ -0,0 +1 @@ +{"Acute lymphocytic leukaemia ": 15.812596111587196, "Acute myeloid leukaemia ": 5.498676222119293, "Acute myocardial infarction ": 2.51947590093894, "Atelectasis ": 5.550066240676565, "Bone disorder ": 4.40870021513675, "Bone lesion ": 21.1461499036955, "Bradycardia ": 4.76426431671323, "Cardiac failure ": 2.8866464699666, "Constipation ": 4.409454140698935, "Cutaneous vasculitis ": 5.137814944953071, "Cytopenia ": 3.3614996845067195, "Death ": 3.432036286069746, "Deep vein thrombosis ": 12.461071063351248, "Disease progression ": 5.423874211474828, "Disorientation ": 2.00625300028967, "Drug intolerance ": 2.168788886952251, "Drug reaction with eosinophilia and systemic symptoms ": 5.232508679075661, "Dysaesthesia ": 4.974378184157472, "Embolism ": 9.526398187641204, "Febrile neutropenia ": 3.443644831636957, "Infection ": 2.6350909874578123, "Myelodysplastic syndrome ": 6.728775349883188, "Neuropathy peripheral ": 36.88539939712409, "Neurotoxicity ": 4.854351083876428, "Neutropenia ": 2.935765394524316, "Oedema ": 2.486531273173087, "Oedema peripheral ": 3.145178411541293, "Orthostatic hypotension ": 3.313992552935185, "Osteonecrosis of jaw ": 12.31537943769507, "Pancytopenia ": 4.191613805125339, "Paraesthesia ": 2.4860527681080287, "Peripheral motor neuropathy ": 68.0896975870547, "Peripheral sensory neuropathy ": 86.03693107542922, "Plasma cell myeloma ": 49.61178118538482, "Plasma cell myeloma recurrent ": 46.55714078620445, "Plasmacytoma ": 74.41602336223518, "Pneumonia ": 2.0727183197664885, "Pneumonitis ": 2.956133445462064, "Polyneuropathy ": 23.35385164384917, "Pulmonary embolism ": 8.641650065482954, "Pulmonary hypertension ": 2.786863653378804, "Rash maculo-papular ": 3.2109750819015503, "Renal impairment ": 2.2589405225942327, "Sepsis ": 4.265431141318596, "Septic shock ": 2.9667337358143904, "Sinus bradycardia ": 4.420869636439437, "Therapy non-responder ": 9.953902823222815, "Toxic skin eruption ": 3.851538552788668, "Transient ischaemic attack ": 2.8797802067650737, "Tumour lysis syndrome ": 8.188848339258541, "Type 2 lepra reaction ": 200.82207246801983, "Varicella zoster virus infection ": 25.852618001457504, "Venous thrombosis limb ": 11.007824549815108} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1067.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1067.json new file mode 100644 index 00000000000..beb358bff02 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1067.json @@ -0,0 +1 @@ +{"Acute lymphocytic leukaemia ": 200.72756871358172, "Decreased appetite ": 4.975512483857825, "Febrile neutropenia ": 17.563989664438253, "Leukopenia ": 10.748193567293193, "Mucosal inflammation ": 27.58822158590593, "Myelosuppression ": 6.927597858062939, "Stomatitis ": 13.94546001504778, "Vomiting ": 2.306500115656245} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1068.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1068.json new file mode 100644 index 00000000000..9e26dfeeb6e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1068.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1069.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1069.json new file mode 100644 index 00000000000..7d2295c11c2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1069.json @@ -0,0 +1 @@ +{"Acute graft versus host disease ": 40.98962384468704, "Acute graft versus host disease in intestine ": 162.54282149464166, "Acute graft versus host disease in skin ": 191.7586418440809, "Acute promyelocytic leukaemia ": 80.76217224837043, "Acute respiratory distress syndrome ": 17.10351741163306, "Adenovirus infection ": 53.87190121599772, "Anaemia ": 4.726986018840199, "Aplastic anaemia ": 16.247896771933043, "Chronic graft versus host disease ": 39.84050064061359, "Chronic graft versus host disease in skin ": 192.51735717586604, "Cystitis haemorrhagic ": 41.35647694111013, "Cytomegalovirus infection reactivation ": 80.80282490665593, "Deafness ": 18.3052108148416, "Febrile neutropenia ": 20.523005794198767, "Focal nodular hyperplasia ": 679.6024211412794, "Graft versus host disease in gastrointestinal tract ": 177.81909816834084, "Graft versus host disease in skin ": 66.86096760754364, "Haematotoxicity ": 34.0783825233434, "Hepatotoxicity ": 15.106087171396371, "Leukopenia ": 2.96137769703598, "Medulloblastoma recurrent ": 2815.918222338205, "Mucosal inflammation ": 62.6153191884963, "Multiple organ dysfunction syndrome ": 4.057598456527057, "Myelodysplastic syndrome ": 13.236047168380043, "Myelosuppression ": 4.700370594290437, "Nervous system disorder ": 14.202169728341207, "Neurotoxicity ": 10.093362038127054, "Neutropenia ": 14.35940609681729, "Off label use ": 3.176041839849927, "Osteosarcoma ": 502.9693174763792, "Pancytopenia ": 2.3438655669244155, "Platelet count decreased ": 2.7444765210459163, "Pneumonia cytomegaloviral ": 65.051301155106, "Product use in unapproved indication ": 5.141231068359846, "Pulmonary arterial hypertension ": 17.042966491558634, "Respiratory distress ": 3.198589154126713, "Second primary malignancy ": 28.662096829500527, "Sepsis ": 5.875374627324435, "Short stature ": 605.5471836042957, "Stomatitis ": 5.199218308356958, "Thrombocytopenia ": 13.79268024687211, "Thrombotic microangiopathy ": 28.27481572516789, "Venoocclusive liver disease ": 49.76301641465533, "Visual impairment ": 6.677342690487749} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/107.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/107.json new file mode 100644 index 00000000000..cf8d96a7c54 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/107.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 4.064997406100146, "Abnormal weight gain ": 3.2338208339504115, "Acarodermatitis ": 40.26032343992639, "Adverse drug reaction ": 2.173322791081207, "Affect lability ": 2.743349457086406, "Affective disorder ": 27.39554159687701, "Aggression ": 4.105577467185708, "Agitation ": 4.197341503834913, "Akathisia ": 85.11145305960358, "Alcohol abuse ": 12.2509768347496, "Anosognosia ": 42.1618890718443, "Anticholinergic syndrome ": 12.204571865402157, "Antipsychotic drug level above therapeutic ": 18.31097742769342, "Antipsychotic drug level below therapeutic ": 447.9641777227113, "Antipsychotic drug level increased ": 15.020719432282585, "Anxiety disorder ": 2.504178228267331, "Appetite disorder ": 2.5827948639750606, "Arteriosclerosis coronary artery ": 5.499371314830549, "Asphyxia ": 2.117518661945191, "Attention deficit hyperactivity disorder ": 2.7461827916883035, "Autonomic nervous system imbalance ": 6.514533841453183, "Basilar artery occlusion ": 87.24618100475831, "Behaviour disorder ": 3.2742267529208524, "Blood albumin decreased ": 8.767597480990874, "Blood creatine phosphokinase increased ": 3.559795083745246, "Blood creatinine decreased ": 3.466555725128508, "Blood insulin increased ": 20.42274415744563, "Blood magnesium increased ": 37.47635948954606, "Blood osmolarity increased ": 20.72789796737924, "Blood prolactin abnormal ": 57.97388693645858, "Blood prolactin increased ": 15.305654980635182, "Blood thyroid stimulating hormone increased ": 7.611731798884625, "Blood triglycerides increased ": 2.5351018818900397, "Blood urea increased ": 2.6548767652603, "Body dysmorphic disorder ": 28.42816700901442, "Body mass index increased ": 11.420850172538229, "Bradykinesia ": 4.68858286478198, "Bruxism ": 10.68217845131717, "Bundle branch block right ": 2.6765516551233097, "C-reactive protein increased ": 2.3449755784753115, "Cardiac dysfunction ": 14.912323591567514, "Cardio-respiratory arrest ": 3.776769937929492, "Cardiomegaly ": 3.375218720684637, "Cardiomyopathy ": 3.614045520542221, "Catatonia ": 28.410243610143063, "Cellulitis ": 3.0785430462790075, "Child abuse ": 222.18240029466912, "Choreoathetosis ": 18.15947099117203, "Clang associations ": 522.9912480746402, "Clonus ": 5.28961378134356, "Cogwheel rigidity ": 57.70585410793287, "Coma scale abnormal ": 4.673031034860035, "Completed suicide ": 4.907639041778065, "Coordination abnormal ": 2.8786317940678807, "Decreased eye contact ": 50.29139779731898, "Delirium ": 2.220644696215056, "Delusion ": 20.01182156367929, "Delusion of grandeur ": 417.46826283698624, "Delusional disorder, unspecified type ": 16.97342171461172, "Depressed mood ": 2.12479692217687, "Depression suicidal ": 2.754034204856714, "Depressive symptom ": 2.8521885842704187, "Dermatitis atopic ": 7.039105799948315, "Diastolic dysfunction ": 13.66317325269608, "Diet refusal ": 12.592630827101331, "Dilatation atrial ": 32.401935786044035, "Disinhibition ": 245.11395618419272, "Disorganised speech ": 6.310039876585936, "Distractibility ": 26.59700556124256, "Disturbance in social behaviour ": 18.907047076525146, "Drooling ": 5.505312935719867, "Drug abuse ": 3.426287647501729, "Drug dependence ": 2.3615565393201656, "Drug effective for unapproved indication ": 2.2516969855361, "Drug ineffective ": 3.25340315548129, "Drug ineffective for unapproved indication ": 2.2124996322347488, "Drug interaction ": 4.666860812128974, "Drug level below therapeutic ": 16.41116639755399, "Drug level increased ": 18.927815436184662, "Drug resistance ": 3.706426213916204, "Dysarthria ": 2.417256057479589, "Dyskinesia ": 5.893708788309645, "Dyslipidaemia ": 34.64062511994929, "Dystonia ": 20.93701941470701, "Dystonic tremor ": 87.28133091259639, "Echocardiogram abnormal ": 35.34326416617147, "Ejection fraction abnormal ": 7.309745540375416, "Electrocardiogram QRS complex prolonged ": 5.1379525926505805, "Electrocardiogram QT prolonged ": 11.210167447230132, "Electrocardiogram ST segment elevation ": 2.22761095216364, "Enuresis ": 3.533273689343762, "Eosinophil count decreased ": 5.29892588856096, "Epidural lipomatosis ": 126.92865730341845, "Euphoric mood ": 65.51680408895152, "Exercise lack of ": 36.91344894337186, "Extrapyramidal disorder ": 49.71137312490698, "Feeling guilty ": 9.991956928369166, "Fibrosis ": 4.04249192681621, "Foetal disorder ": 66.23098502811347, "Food craving ": 12.503472841667328, "Galactorrhoea ": 4.747142421447222, "Gambling disorder ": 9.532978621218872, "Gaze palsy ": 3.355255353087626, "Globulins increased ": 138.21192701213536, "Glomerular filtration rate decreased ": 2.990640585915975, "Gynaecomastia ": 5.567180546832834, "Hallucination, auditory ": 26.46381726033198, "Hallucination, tactile ": 79.60494627119607, "Hallucination, visual ": 4.871560546516728, "Hallucinations, mixed ": 10.30444529928772, "Head titubation ": 34.14931260645772, "Hepatic fibrosis ": 4.629840248078052, "Herpes simplex ": 5.0937355205259935, "High density lipoprotein decreased ": 23.527148350132716, "Homicidal ideation ": 6.961820042766228, "Hospitalisation ": 2.444667646483264, "Hypercapnia ": 4.559236591096972, "Hyperkinesia ": 6.00661033611456, "Hypernatraemia ": 2.90542864341034, "Hyperphagia ": 8.616134703795868, "Hyperprolactinaemia ": 31.138686187810755, "Hyperreflexia ": 5.257311402388835, "Hypersexuality ": 17.839528543460126, "Hypertonia ": 6.1607699512230045, "Hypomania ": 16.67201745041211, "Hypophagia ": 3.1379962320046646, "Hyporeflexia ": 3.150018199461718, "Hypoventilation ": 4.25043684137485, "Hypovolaemia ": 2.527935899172644, "Impulsive behaviour ": 5.238671227295008, "Incorrect dose administered ": 3.075388076211569, "Increased appetite ": 53.62855523011491, "Intentional overdose ": 2.745510753742048, "Intentional product misuse ": 3.1354624893195746, "Intentional self-injury ": 4.344609136199009, "Intracranial pressure increased ": 8.298674014085774, "Iron deficiency ": 2.778131293685698, "Iron deficiency anaemia ": 3.550384311307794, "Iron metabolism disorder ": 68.73750605881673, "Irritability ": 4.686009930732643, "Juvenile idiopathic arthritis ": 8.318444244867306, "Left atrial dilatation ": 70.76812422138548, "Left ventricular dysfunction ": 16.875062162135812, "Leukaemia ": 29.141245774450045, "Leukocytosis ": 5.213339869676421, "Leukopenia ": 9.876281019446289, "Logorrhoea ": 3.9993227028455474, "Low birth weight baby ": 5.164813251049623, "Low density lipoprotein increased ": 3.670973717715072, "Lymphocyte count abnormal ": 147.01611245066317, "Lymphocyte count decreased ": 17.935804039484506, "Lymphocyte count increased ": 9.74018195540024, "Mania ": 9.613997180296854, "Maternal exposure during pregnancy ": 2.192177892259071, "Mean cell haemoglobin concentration decreased ": 11.68731339176432, "Mean cell haemoglobin decreased ": 13.97068263833318, "Mean cell haemoglobin increased ": 8.466790627019492, "Mean cell volume decreased ": 8.81982534180345, "Mental disorder ": 2.7768600865340187, "Mental impairment ": 4.027447556640392, "Metabolic disorder ": 9.3886624329378, "Metabolic syndrome ": 8.848245356332344, "Mitral valve incompetence ": 3.930243467468784, "Monocyte count increased ": 5.406511959835667, "Mood altered ": 4.223109665906919, "Mucosal inflammation ": 4.518729412928821, "Muscle rigidity ": 8.69442998861359, "Mutism ": 20.359318302123377, "Myocarditis ": 2.1106098592159195, "Myoclonic epilepsy ": 4.043547934673387, "Myoclonus ": 2.771875190166911, "Negative symptoms in schizophrenia ": 336.35450396468894, "Negative thoughts ": 5.534869683783612, "Negativism ": 22.98890708770908, "Nephrogenic diabetes insipidus ": 6.075008804696153, "Neuroleptic malignant syndrome ": 16.891524258120143, "Neutropenia ": 2.402313699072564, "Neutropenia neonatal ": 315.0970474243834, "Neutrophil count decreased ": 2.10649359302317, "Neutrophil count increased ": 37.5973461240653, "Neutrophilia ": 3.744807748740549, "Non-alcoholic steatohepatitis ": 15.601449555278444, "Non-high-density lipoprotein cholesterol increased ": 329.22375476520955, "Obesity ": 24.241186139837545, "Obsessive-compulsive disorder ": 117.3795063365944, "Obsessive-compulsive symptom ": 36.54650113837572, "Oculogyric crisis ": 20.9825861799108, "Oppositional defiant disorder ": 56.747105827895965, "Orthostatic hypertension ": 19.919707695499664, "Orthostatic hypotension ": 5.218172251666927, "Overdose ": 2.728068595657529, "Panic disorder ": 5.8393192665911, "Paradoxical drug reaction ": 5.962776736786875, "Paranoia ": 8.105322564801313, "Parkinsonism ": 19.476646667807582, "Persecutory delusion ": 24.16745361524234, "Personality change ": 5.008573926948478, "Poisoning deliberate ": 2.259781854904412, "Post-traumatic pain ": 34.45165026324748, "Posture abnormal ": 4.453217077207204, "Pregnancy ": 3.740028233587971, "Premature baby ": 4.331184355440571, "Premature delivery ": 12.103564334365316, "Prescribed overdose ": 11.66995420164655, "Priapism ": 8.957155721246615, "Product administered to patient of inappropriate age ": 3.601808732175522, "Product prescribing error ": 3.5915546525770385, "Product use in unapproved indication ": 3.835707431722695, "Product use issue ": 2.954572614324533, "Progressive multiple sclerosis ": 62.88352257039343, "Psychiatric decompensation ": 7.010423144443448, "Psychiatric symptom ": 2.927547562623122, "Psychomotor hyperactivity ": 5.782475623119649, "Psychomotor retardation ": 9.64387681118675, "Psychotic disorder ": 16.530663174878203, "Psychotic symptom ": 45.83573673100216, "Pulmonary valve incompetence ": 49.95312312673681, "Quadriparesis ": 4.793679542426659, "Rebound effect ": 5.1057221181270105, "Red blood cell count decreased ": 2.6930901219451564, "Red cell distribution width increased ": 21.73103580475072, "Respiratory acidosis ": 4.605727059760719, "Respiratory arrest ": 2.4309440901151875, "Respiratory depression ": 8.268090475588757, "Resting tremor ": 14.277963504671536, "Restless legs syndrome ": 2.884664987085026, "Restlessness ": 3.141733570570855, "Rhinalgia ": 44.787682709061805, "SARS-CoV-2 test positive ": 5.055686036140761, "Salivary hypersecretion ": 12.638884327685249, "Schizoaffective disorder ": 398.5707204731624, "Schizophrenia ": 55.59312275978137, "Sedation ": 15.833328665914992, "Sedation complication ": 29.505922060677715, "Self-destructive behaviour ": 4.178092668908295, "Self-injurious ideation ": 2.8863381867070266, "Self-medication ": 8.77257362637516, "Serotonin syndrome ": 8.620531324107283, "Sexual dysfunction ": 10.466426764176166, "Sinus bradycardia ": 2.422914860907392, "Sinus rhythm ": 101.9993437467453, "Sinus tachycardia ": 6.621682081730261, "Social anxiety disorder ": 48.88008588345872, "Social avoidant behaviour ": 9.2047101143297, "Somatic symptom disorder ": 9.34803831619484, "Spasmodic dysphonia ": 83.15261524671358, "Staring ": 3.8802920195878094, "Steatohepatitis ": 32.999233738993965, "Streptococcal infection ": 4.487499886645684, "Substance use ": 12.077966528559744, "Suicidal behaviour ": 4.0640797031411084, "Suicidal ideation ": 3.1130531623117155, "Suicide attempt ": 11.118826854885564, "Suspected suicide ": 10.09989538590415, "Sydenham's chorea ": 449.1255590127831, "Systolic dysfunction ": 44.36758355966221, "Tardive dyskinesia ": 25.34287686097129, "Tearfulness ": 2.079278683547065, "Tenderness ": 3.8349396066396895, "Tension ": 3.481964684966067, "Thalassaemia ": 71.05726999832552, "Therapeutic product effect incomplete ": 9.361426855363664, "Therapeutic product effect variable ": 274.25936814407856, "Therapeutic response decreased ": 2.7355636651722373, "Therapy non-responder ": 2.1016553052772387, "Thinking abnormal ": 3.886836219375753, "Thoracic vertebral fracture ": 5.004138490426339, "Thyroxine decreased ": 69.84664286368881, "Torticollis ": 8.550532260448895, "Toxicity to various agents ": 7.685911246360181, "Treatment noncompliance ": 8.514982289072623, "Tri-iodothyronine decreased ": 102.5309717712155, "Tricuspid valve incompetence ": 3.744870005923802, "Trismus ": 4.483651446744608, "Troponin T increased ": 33.05399402030148, "Troponin increased ": 7.415469978575703, "Urinary incontinence ": 2.020438328280321, "Ventricular hypokinesia ": 3.842878452608796, "Victim of child abuse ": 113.05093529601352, "Vitamin B12 increased ": 52.63814127375192, "Weight abnormal ": 15.918601568440556, "Weight increased ": 8.56854107266457, "White blood cell count increased ": 2.2014333628548237} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1070.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1070.json new file mode 100644 index 00000000000..6a1c96c2b25 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1070.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 227.04082780582536, "Maternal exposure during pregnancy ": 96.34696146561234} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1071.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1071.json new file mode 100644 index 00000000000..d165cae480a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1071.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 4.833472647267703, "Acute kidney injury ": 2.468818293486269, "Acute myocardial infarction ": 8.448810431637515, "Amaurosis ": 39.52333191306073, "Angina unstable ": 5.615154263583051, "Asphyxia ": 37.63570374965063, "Atrioventricular block ": 5.77635850162484, "Atrioventricular block complete ": 6.731418726769471, "Blood loss anaemia ": 50.74725054408197, "Bronchial haemorrhage ": 95.99923570525895, "Cardiogenic shock ": 3.040671287583894, "Cerebral haemorrhage ": 7.171756197195853, "Chest discomfort ": 9.460401999354136, "Chronic gastritis ": 48.18818488575063, "Conjunctival haemorrhage ": 10.210196166291176, "Coronary artery occlusion ": 6.677786758875344, "Coronary artery stenosis ": 15.183550255424525, "Diarrhoea haemorrhagic ": 10.417887976840806, "Drug interaction ": 4.957388398314164, "Duodenal ulcer ": 15.889728071557718, "Duodenal ulcer haemorrhage ": 32.86101281959504, "Dyspnoea ": 4.729598761683767, "Dyspnoea at rest ": 16.622340433961543, "Ecchymosis ": 19.24954589386545, "Electrocardiogram ST segment elevation ": 6.6434971709886135, "Epistaxis ": 6.616247987252902, "Eye haemorrhage ": 2.471622456330378, "Faeces discoloured ": 16.77884091353526, "Gastric haemorrhage ": 9.73669946209261, "Gastric mucosal lesion ": 67.19114694267986, "Gastric ulcer ": 7.5418794805671965, "Gastric ulcer haemorrhage ": 20.12180399203093, "Gastritis erosive ": 18.46889262153336, "Gastrointestinal haemorrhage ": 26.04518349788933, "Gingival bleeding ": 14.890783877736542, "Gout ": 5.717688853474336, "Haematemesis ": 32.75904461306297, "Haematochezia ": 17.490500659589728, "Haematoma ": 3.075330957252272, "Haematuria ": 9.169292620862317, "Haemoglobin decreased ": 6.542218569003436, "Haemoptysis ": 11.78474493545197, "Haemorrhage ": 3.423993774908652, "Haemorrhage intracranial ": 12.488215838481278, "Haemorrhage subcutaneous ": 28.148778203318603, "Haemorrhage urinary tract ": 13.819169447400435, "Haemorrhoidal haemorrhage ": 10.6583566207891, "Haemothorax ": 11.45930800695112, "Incorrect dose administered ": 2.1559789812340373, "Iron deficiency anaemia ": 4.469980941847617, "Labelled drug-drug interaction issue ": 220.60996919041324, "Labelled drug-drug interaction medication error ": 199.4374895009144, "Lower gastrointestinal haemorrhage ": 62.99539964068568, "Melaena ": 59.43854388157198, "Myopathy ": 4.604628449945429, "Occult blood positive ": 35.740598372901744, "Pericardial haemorrhage ": 16.089366722855882, "Platelet aggregation inhibition ": 471.91629779597486, "Post procedural haemorrhage ": 5.864217060738054, "Product administration error ": 3.3964352939835822, "Product prescribing issue ": 28.85639652403592, "Pulmonary alveolar haemorrhage ": 14.28467889812784, "Pulmonary haemorrhage ": 14.73140373657302, "Purpura ": 2.5606403193661684, "Rectal haemorrhage ": 4.633215208097326, "Respiratory rate increased ": 6.941773923038289, "Respiratory tract haemorrhage ": 38.35344174403821, "Rhabdomyolysis ": 12.100416845817044, "Shock haemorrhagic ": 8.554998460301464, "Sinus arrest ": 44.90060240060416, "Subarachnoid haemorrhage ": 11.808347174243016, "Subdural haematoma ": 4.562433482018913, "Tachypnoea ": 8.387425090653139, "Thrombotic thrombocytopenic purpura ": 6.361380751466973, "Treatment noncompliance ": 2.6151451612268586, "Upper gastrointestinal haemorrhage ": 123.53121169706012, "Vascular stent thrombosis ": 30.77366095198895, "Ventricular asystole ": 129.26035004649873} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1072.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1072.json new file mode 100644 index 00000000000..7ab3e7affcd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1072.json @@ -0,0 +1 @@ +{"Acinetobacter infection ": 279.0412634880268, "Acute respiratory distress syndrome ": 22.622277115187547, "Bacteraemia ": 36.50545089236813, "Blood bilirubin increased ": 5.640249190247344, "Coagulopathy ": 13.385699435208718, "Condition aggravated ": 4.308569571404217, "Drug ineffective ": 6.491071222586458, "Drug resistance ": 27.81282443104805, "Electrocardiogram QT prolonged ": 4.713881439747022, "Hepatic function abnormal ": 6.831461780872209, "Klebsiella infection ": 173.65006107216314, "Liver function test abnormal ": 10.803848506217888, "Liver injury ": 10.461446568340955, "Mental status changes ": 13.065675539197924, "Off label use ": 3.912522559215336, "Pancreatitis acute ": 7.469700010507458, "Pathogen resistance ": 136.85464308207028, "Platelet count decreased ": 3.361274845497193, "Product use issue ": 3.2802729536254747, "Pseudomembranous colitis ": 42.06122203494714, "Sepsis ": 4.96673712352168, "Septic shock ": 8.16353936224208, "Thrombocytopenia ": 2.622345071050122, "Tinnitus ": 3.817653691905613} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1073.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1073.json new file mode 100644 index 00000000000..3593444ea49 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1073.json @@ -0,0 +1 @@ +{"Arrhythmia ": 7.027505058064821, "Atrial fibrillation ": 24.69335469179725, "Drug interaction ": 5.800276807716031, "Electrocardiogram QT prolonged ": 10.489360458467567, "Heart rate decreased ": 14.197114362627648, "Heart rate increased ": 6.239990256040112, "Visual impairment ": 3.519889071561064} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1074.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1074.json new file mode 100644 index 00000000000..486bb65ce1c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1074.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 6.690969155934481, "Acute lymphocytic leukaemia recurrent ": 213.7602463923735, "Cytokine release syndrome ": 372.884739585333, "Diffuse large B-cell lymphoma ": 116.7143615763726, "Disease progression ": 5.537481926080544, "Disseminated intravascular coagulation ": 38.38684237003344, "Encephalopathy ": 28.856036376113, "Febrile neutropenia ": 13.811249080970205, "Haemophagocytic lymphohistiocytosis ": 61.20934212873309, "Hypotension ": 4.229529676385023, "Hypoxia ": 17.688184690083133, "Immune effector cell-associated neurotoxicity syndrome ": 378.3965970313274, "Lymphopenia ": 75.03930993327171, "Malignant neoplasm progression ": 2.229553208403124, "Neurotoxicity ": 33.45867697076864, "Neutropenia ": 3.2785808705731547, "Neutrophil count decreased ": 22.27787845533811, "Platelet count decreased ": 5.951540828268608, "Sepsis ": 4.639928608539302, "Tumour lysis syndrome ": 45.50688407212719, "White blood cell count decreased ": 12.273883794568777} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1075.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1075.json new file mode 100644 index 00000000000..c67e29a61fa --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1075.json @@ -0,0 +1 @@ +{"Myelosuppression ": 150.64707793241547, "Neutrophil count decreased ": 47.262203783402434, "Off label use ": 2.4125997107597814, "Platelet count decreased ": 25.45588638138306, "White blood cell count decreased ": 40.15888725408857} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1076.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1076.json new file mode 100644 index 00000000000..d60eb04676c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1076.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 7.369999789464062, "Amnesia ": 2.595667529497314, "Blood HIV RNA increased ": 113.2947565518387, "Blood calcium increased ": 10.782368581468528, "Blood creatine phosphokinase increased ": 3.699981670724645, "Blood creatinine increased ": 4.0523572205468845, "Cholestasis ": 2.9158428083437973, "Deafness ": 2.841806514409853, "Depressed mood ": 3.033685811126822, "Depression ": 2.839720441796729, "Dermatitis ": 4.247386074521855, "Drug resistance ": 3.075588478323166, "Dysuria ": 3.0409831746805933, "Glomerular filtration rate decreased ": 4.202684904602609, "Hepatic cytolysis ": 2.5171205234106626, "Hepatic failure ": 2.2570005405403166, "Hepatitis ": 4.701953903118595, "Hospitalisation ": 3.4045985499987865, "Hyperlipidaemia ": 6.78991836222758, "Immune reconstitution inflammatory syndrome ": 117.08157361621396, "Inhibitory drug interaction ": 40.90244930920812, "Insomnia ": 3.201936467142211, "Intervertebral disc disorder ": 25.18928080442944, "Jaundice ": 2.113807371817753, "Kaposi's sarcoma ": 36.84762850203537, "Lactic acidosis ": 2.584505602748674, "Lipodystrophy acquired ": 16.553652358115084, "Liver function test abnormal ": 2.8860344175572226, "Liver function test increased ": 3.2125968792793502, "Lymphoma ": 10.450593910608385, "Major depression ": 16.01999119556906, "Mental disorder ": 5.391991499208519, "Mycoplasma infection ": 155.73506054310172, "Nephropathy ": 3.4347291586537425, "Nervous system disorder ": 4.602720773527096, "Nervousness ": 2.4960177052602344, "Neurotoxicity ": 23.15917344924086, "Nightmare ": 5.080839812983594, "Osteopenia ": 3.734166142319564, "Pancreatitis ": 2.5533012752926343, "Pathogen resistance ": 11.68661893294461, "Pneumocystis jirovecii pneumonia ": 7.291528400449626, "Progressive multifocal leukoencephalopathy ": 20.686411956313982, "Proteinuria ": 2.5393731250062097, "Psychotic disorder ": 2.9926273487737465, "Renal failure ": 2.317494151286797, "Renal impairment ": 3.805343784163744, "Sleep disorder ": 3.6675845786876895, "Suicidal ideation ": 6.1280402287620594, "Suicide attempt ": 2.0921659789941742, "Transaminases increased ": 3.5362557579820164, "Treatment noncompliance ": 6.366920213471998, "Tuberculosis ": 12.91509444304382, "Upper-airway cough syndrome ": 29.04998167215432, "Urethral discharge ": 1037.6759625949808, "Urethritis ": 120.02154130022788, "Viral load increased ": 42.6312920656961, "Viral mutation identified ": 23.3951337681442, "Virologic failure ": 13.700562716154405, "Weight increased ": 2.5727958342652557} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1077.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1077.json new file mode 100644 index 00000000000..56b5c49d294 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1077.json @@ -0,0 +1 @@ +{"Bronchospasm ": 71.21449624211903, "Chest discomfort ": 8.083505292931292, "Condition aggravated ": 2.514484175069501, "Cough ": 12.825390400611669, "Cystic fibrosis ": 706.7825124193597, "Death ": 2.662542502907519, "Drug intolerance ": 7.478322078284209, "Dyspnoea ": 4.937798022050716, "Forced expiratory volume decreased ": 189.36367883747508, "Haemoptysis ": 72.22021283293803, "Infection ": 4.371839808250974, "Lower respiratory tract infection ": 10.94610738108935, "Oxygen saturation decreased ": 12.154623634098035, "Pneumonia ": 3.457184468562118, "Pulmonary function test decreased ": 166.51235418965229, "Wheezing ": 9.034577800287948} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1078.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1078.json new file mode 100644 index 00000000000..a9d76304a25 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1078.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 13.0797155076361, "Blindness ": 3.5442191013587165, "Blood alkaline phosphatase increased ": 2.270878993529436, "Blood creatinine increased ": 6.760496047570615, "Blood pressure decreased ": 2.054228825580104, "Blood urea increased ": 11.694635508630489, "Bronchospasm ": 9.03659129074215, "Clostridium difficile colitis ": 7.330993510280246, "Colitis ": 6.109173088166035, "Condition aggravated ": 2.067618466170088, "Conjunctivitis ": 4.69846648538013, "Corneal opacity ": 50.27483862616008, "Creatinine renal clearance decreased ": 25.58619062807742, "Cystic fibrosis ": 77.28903628029178, "Deafness ": 7.869634104270363, "Deafness neurosensory ": 46.524488193918536, "Drug clearance decreased ": 142.21029874448897, "Drug hypersensitivity ": 4.071393377598039, "Drug ineffective ": 2.3000945416119776, "Drug level increased ": 19.419871543939724, "Drug resistance ": 9.636538525884005, "Eosinophil count abnormal ": 74.65641238920456, "Eosinophilia ": 4.763391445780803, "Eye pain ": 3.4165936959212977, "Eye swelling ": 3.379485528471644, "Eyelid oedema ": 5.160497237279721, "Graft versus host disease ": 10.042811175242203, "Haemoptysis ": 2.673796057072801, "Hypoacusis ": 5.694307325151266, "Hypopyon ": 63.85817046197631, "Hypotension ": 2.726795557140399, "Incorrect route of product administration ": 3.3041985821778623, "Infection ": 2.1847065729397137, "Keratitis ": 51.800995212431694, "Lactic acidosis ": 2.488585383059465, "Leukocytosis ": 5.886981850906022, "Lung disorder ": 2.7022443059056065, "Multiple organ dysfunction syndrome ": 3.664853757759001, "Nephrolithiasis ": 2.809823942435975, "Nephropathy toxic ": 15.63470794955351, "Ocular hyperaemia ": 6.195404658368457, "Ototoxicity ": 174.24190923011594, "Pathogen resistance ": 45.98290959042277, "Pneumonia pseudomonal ": 53.40531967015604, "Productive cough ": 2.4334306499190306, "Pseudomembranous colitis ": 46.61018151627578, "Pseudomonas infection ": 51.875778004570485, "Pulmonary hypertension ": 4.374604381434981, "Renal impairment ": 4.570455530843854, "Renal tubular necrosis ": 76.80143955603143, "Respiratory disorder ": 5.513658245695871, "Respiratory rate decreased ": 25.097384826881523, "Sepsis ": 2.9687810000304475, "Septic shock ": 6.001593484832365, "Staphylococcal infection ": 6.208773911674653, "Therapy non-responder ": 3.680560491155068, "Tinnitus ": 3.927624229707052, "Toxic anterior segment syndrome ": 55.38051686224862, "Toxic epidermal necrolysis ": 8.230342361227871, "Ulcerative keratitis ": 48.27170811765266, "Visual acuity reduced ": 5.19426476495989, "White blood cell count increased ": 4.034530455565668} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1079.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1079.json new file mode 100644 index 00000000000..8bd7521e23e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1079.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 2.014991254861531, "Anaphylactic reaction ": 3.16100888584066, "Arthritis ": 4.689665923864119, "C-reactive protein increased ": 2.4315030799917805, "COVID-19 pneumonia ": 7.916775757877641, "Cellulitis ": 7.70476162899105, "Cytokine release syndrome ": 4.824919427073132, "Diverticular perforation ": 57.97647247760111, "Diverticulitis ": 11.816352630252007, "Empyema ": 55.94500559302732, "Haemophagocytic lymphohistiocytosis ": 25.374087184507168, "Hepatic cytolysis ": 2.26173701865858, "Hepatitis ": 6.490518867366277, "Hypercholesterolaemia ": 6.712580878038252, "Hypofibrinogenaemia ": 615.2547251291676, "Hypoxia ": 2.793792458103257, "Infusion related reaction ": 2.5674632269032647, "Intentional product use issue ": 19.627492512694943, "Intestinal perforation ": 23.396485670310167, "Large intestine perforation ": 34.54522123446803, "Leukopenia ": 4.049179285731845, "Neutropenia ": 5.591501546356307, "Neutrophil count decreased ": 2.147475921532841, "No adverse event ": 5.220093348720895, "Off label use ": 7.578902244685533, "Organising pneumonia ": 15.887612891414657, "Pancreatitis acute ": 2.2222536563324087, "Pneumonia ": 2.1753509830563424, "Product use in unapproved indication ": 2.3826606891031403, "Respiratory failure ": 2.242092979196247, "Sepsis ": 4.299022856788757, "Septic shock ": 5.781739902488358, "Staphylococcal infection ": 3.912014760890768, "Therapy non-responder ": 2.250168461349831, "Transaminases increased ": 4.720484109798611, "Urinary tract infection ": 2.03676560152188, "Vasculitis ": 5.825689795595157} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/108.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/108.json new file mode 100644 index 00000000000..de6a807d39a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/108.json @@ -0,0 +1 @@ +{"Abdominal wall haematoma ": 70.51519536618059, "Acute generalised exanthematous pustulosis ": 13.558215731959434, "Acute kidney injury ": 2.01767067173518, "Anaemia ": 7.857211504725206, "Blood alkaline phosphatase increased ": 3.456069793688746, "Blood loss anaemia ": 44.05024982817037, "Bronchospasm ": 3.66512353857739, "Cardiac arrest ": 2.228897879388682, "Cerebral haemorrhage ": 11.069180822578817, "Cholestasis ": 5.817716679103597, "Chromaturia ": 11.441608480541724, "Coagulopathy ": 7.904383536646639, "Coma ": 2.305248203011274, "Deep vein thrombosis ": 2.794004113644586, "Dermatitis allergic ": 5.038670178741249, "Drug reaction with eosinophilia and systemic symptoms ": 3.772875855038649, "Eosinophilia ": 6.687854768100896, "Exposure during pregnancy ": 4.472023273172317, "Gamma-glutamyltransferase increased ": 3.6155011095293967, "Gastrointestinal haemorrhage ": 4.525780544756375, "Haematemesis ": 15.211714430613116, "Haematoma ": 41.13495550792344, "Haematoma muscle ": 75.38139348792014, "Haematuria ": 6.903668053939697, "Haemoglobin decreased ": 3.8825875924515976, "Haemorrhage ": 6.716240857934408, "Haemorrhagic stroke ": 12.967585947209905, "Heparin-induced thrombocytopenia ": 17.00200692193224, "Hepatic cytolysis ": 4.972557145476923, "Inflammation ": 2.618577717496235, "International normalised ratio increased ": 4.262828652879841, "Liver injury ": 3.9336780650627032, "Melaena ": 9.260221237153402, "Mixed liver injury ": 32.9126697180814, "Muscle haemorrhage ": 77.7148033002511, "Pulmonary embolism ": 3.0498742035085766, "Rash maculo-papular ": 17.28816975892597, "Rectal haemorrhage ": 6.291578025545048, "Septic shock ": 6.398672618912167, "Shock haemorrhagic ": 55.90311496897804, "Subarachnoid haemorrhage ": 13.267803265070238, "Subdural haematoma ": 28.4468661081193, "Subdural haemorrhage ": 37.39592895397138, "Tendon rupture ": 7.886298648816006, "Thrombocytopenia ": 5.829588616322615, "Transaminases increased ": 4.31299370868001, "Vaginal haemorrhage ": 4.369567826302657} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1080.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1080.json new file mode 100644 index 00000000000..dc410c53252 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1080.json @@ -0,0 +1 @@ +{"Blood creatinine increased ": 6.501998249629692, "Eczema ": 15.21187802587053, "Erythema ": 3.337175232553817, "Swelling ": 4.8010335575525485} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1081.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1081.json new file mode 100644 index 00000000000..86bef5d956d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1081.json @@ -0,0 +1 @@ +{"Condition aggravated ": 3.109116022126352, "Cytomegalovirus infection reactivation ": 67.43635724112387, "Deep vein thrombosis ": 5.057627676767332, "Herpes zoster ": 3.9688817048490073, "Joint swelling ": 4.312288669455672, "Off label use ": 2.287158716890312, "Pulmonary embolism ": 5.458139007201937, "Rheumatoid arthritis ": 4.11645173799976, "Treatment failure ": 11.94247258971962} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1082.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1082.json new file mode 100644 index 00000000000..25559ffa50c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1082.json @@ -0,0 +1 @@ +{"Cough ": 8.733597327554772} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1083.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1083.json new file mode 100644 index 00000000000..da73ad2248d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1083.json @@ -0,0 +1 @@ +{"Blood pressure decreased ": 12.857949718216082, "Cardiac failure ": 10.880075358295745, "Drug ineffective ": 2.0522441958704065, "Drug interaction ": 6.088677632461509, "Hypernatraemia ": 175.80328272586783, "Product use in unapproved indication ": 6.1772332372219525, "Renal impairment ": 8.282371217185235, "Sepsis ": 10.057500191384774} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1084.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1084.json new file mode 100644 index 00000000000..605394dcc2f --- 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1085.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1085.json new file mode 100644 index 00000000000..49d5b7ebecb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1085.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.905409084821205, "Acute respiratory failure ": 3.3555354295531385, "Anaemia ": 2.98562578075412, "Angioedema ": 2.593441455580831, "Aphthous ulcer ": 9.09863849925276, "Ascites ": 3.935584745180045, "Blood alkaline phosphatase increased ": 3.923368540893705, "Blood creatinine increased ": 7.317667885973548, "Blood lactate dehydrogenase increased ": 2.6574965554513503, "Blood triglycerides increased ": 13.50879310967688, "Blood urea increased ": 4.145565248902495, "C-reactive protein increased ": 2.218480462493136, "Cerebral haemorrhage ": 2.760483759069148, "Death ": 4.208830709779996, "Dehydration ": 2.0036839773924124, "Diabetes 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1086.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1086.json new file mode 100644 index 00000000000..96efca172db --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1086.json @@ -0,0 +1 @@ +{"Asphyxia ": 3.1347416653246403, "Blindness ": 5.665544494556956, "Blood glucose abnormal ": 31.597072799389988, "Blood glucose decreased ": 27.680425353446108, "Blood glucose fluctuation ": 36.943233230655885, "Blood glucose increased ": 31.48533019181776, "Caesarean section ": 6.202470264167431, "Cardiac disorder ": 2.6994414625406207, "Cataract ": 7.476190820516678, "Cerebrovascular accident ": 2.801682993135879, "Dementia ": 6.092282818276282, "Device defective ": 35.492507007626386, "Device delivery system issue ": 18.7685460851876, "Device issue ": 29.77402528459545, "Device leakage ": 6.918160748120319, "Device occlusion ": 10.82765539844747, "Device 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"Vaccination site bruising ": 6.428050111348359, "Vaccination site cellulitis ": 7.717756207141136, "Vaccination site discolouration ": 2.868779132931291, "Vaccination site haemorrhage ": 7.229896800170886, "Vaccination site hypersensitivity ": 2.906856411826692, "Vaccination site hypoaesthesia ": 7.009088563103866, "Vaccination site infection ": 3.34489649773022, "Vaccination site joint movement impairment ": 3.7230479611713263, "Vaccination site mass ": 10.541851363776289, "Vaccination site movement impairment ": 2.71175575432915, "Vaccination site nodule ": 2.622805498291795, "Vaccination site pain ": 2.0383860176818103, "Vaccination site paraesthesia ": 2.4717160890073604, "Vaccination site rash ": 3.1303716699667103, "Vaccination site urticaria ": 3.875361716620084, "Vaccination site warmth ": 2.798519888614446, "Vaginal haemorrhage ": 2.968841611225828, "Vascular headache ": 2.4554467342957302, "Vertigo positional ": 2.162057360441903, "Vestibular migraine ": 6.930457399542347, "Vestibular neuronitis ": 2.062572706111652, "Viral pharyngitis ": 2.645689076482844, "Viral rash ": 2.640952684133594, "Visual snow syndrome ": 3.5446272312075773, "Vomiting projectile ": 2.3734938015381157, "Vulval haemorrhage ": 10.100763130343555, "Vulval ulceration ": 3.714884121069701} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1089.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1089.json new file mode 100644 index 00000000000..3dfa786eb26 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1089.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.6540066578012853, "Alanine aminotransferase increased ": 7.781080583349353, "Anaemia ": 7.232512751105886, "Asthenia ": 2.1408646200046126, "Disease progression ": 4.981324741267289, "Febrile neutropenia ": 10.616668020940304, "Hepatotoxicity ": 19.16477250008546, "Hypertransaminasaemia ": 61.68296180850008, "Leukopenia ": 6.014067022917677, "Neutropenia ": 19.825730184724065, "Off label use ": 2.111934115910729, "Pancytopenia ": 13.470615035928716, "Product use in unapproved indication ": 3.3695815129012514, "Rhabdomyolysis ": 36.30981724335528, "Thrombocytopenia ": 9.63781859041453, "Transaminases increased ": 26.37968066570296} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/109.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/109.json new file mode 100644 index 00000000000..92dd7828d0a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/109.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 83.77124325345295, "Agitation ": 7.903658225681238, "Anxiety ": 5.906182057917096, "Depression ": 3.504193887030684, "Drug interaction ": 6.009614643584133, "Drug withdrawal syndrome ": 20.446490172271535, "Electrocardiogram QT prolonged ": 253.63140734918252, "Hyperhidrosis ": 3.787697675690107, "Leukaemia recurrent ": 1480.678075625734, "Obsessive thoughts ": 438.63740015950617, "Tremor ": 3.801050519230832} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1090.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1090.json new file mode 100644 index 00000000000..8832bae4fd7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1090.json @@ -0,0 +1 @@ +{"Abortion induced ": 6.086982017000009, "Acute respiratory distress syndrome ": 2.070060503098204, "Acute respiratory failure ": 6.624762921550798, "Alanine aminotransferase increased ": 16.617943678441424, "Ammonia increased ": 2.150567695161058, "Angioplasty ": 8.806714440816204, "Anuria ": 2.339000068891427, "Aortic stenosis ": 6.174466580238899, "Ascites ": 5.747668120628645, "Aspartate aminotransferase increased ": 18.86373775276574, "Atrial flutter ": 5.94304999987833, "Atrial septal 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"Concomitant disease aggravated ": 11.830409118923937, "Concomitant disease progression ": 7.660170385690843, "Condition aggravated ": 4.040791798761954, "Congestive hepatopathy ": 33.590721466936046, "Cor pulmonale ": 75.32183481054007, "Cyanosis ": 3.1986955306397427, "Death ": 10.7464331906387, "Device alarm issue ": 36.71919103493391, "Device breakage ": 8.127515255569795, "Device dislocation ": 7.139094717105061, "Device infusion issue ": 14.312000949565482, "Device leakage ": 12.499527746502226, "Device malfunction ": 2.356471818319452, "Device occlusion ": 11.960816242960972, "Device physical property issue ": 9.672664379727996, "Device related infection ": 10.561521861526485, "Device related sepsis ": 13.396763461393135, "Dialysis ": 7.093199902209117, "Disease complication ": 24.96451421504545, "Disease progression ": 6.610990059364696, "Dyspnoea ": 2.893974703636085, "Dyspnoea exertional ": 4.141406100953541, "Echocardiogram abnormal ": 8.83963864030103, "Endarterectomy ": 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": 101.10920016670671, "Mechanical ventilation ": 16.09085387542, "Medical device change ": 47.81268563204908, "Mineral supplementation ": 43.14966987734736, "Multiple organ dysfunction syndrome ": 3.7653623141773607, "N-terminal prohormone brain natriuretic peptide increased ": 5.34967562309036, "Normal newborn ": 3.4407828708352364, "Ocular icterus ": 3.8830844366291073, "Oedema ": 4.875915566124861, "Oedema peripheral ": 4.762629962140861, "Orthopnoea ": 8.420093556048611, "Oxygen consumption increased ": 29.742254816213222, "Oxygen saturation abnormal ": 7.189704036274527, "Oxygen saturation decreased ": 6.225367342205363, "Oxygen therapy ": 5.5005768303592655, "Pain in jaw ": 4.122891400100203, "Paracentesis ": 31.727211363231174, "Pericardial effusion ": 4.794408175707647, "Platelet transfusion ": 11.800070091411234, "Pleural effusion ": 3.2224525026407527, "Pneumonia ": 3.926906343292319, "Pneumonia aspiration ": 2.1604316075228915, "Pneumonia viral ": 3.654001643077791, "Pneumothorax ": 3.285757160738092, "Post procedural complication ": 4.00504605451263, "Pregnancy ": 12.145529984146064, "Prothrombin time prolonged ": 2.5481573219932674, "Pulmonary arterial hypertension ": 140.41012890439302, "Pulmonary arterial pressure increased ": 34.96529188329854, "Pulmonary congestion ": 3.4119826193508467, "Pulmonary fibrosis ": 5.972027503145929, "Pulmonary haemorrhage ": 5.261708859275798, "Pulmonary hypertension ": 49.42326982649671, "Pulmonary hypertensive crisis ": 157.9687662366876, "Pulmonary oedema ": 5.329283667921053, "Pulmonary veno-occlusive disease ": 23.360554708260626, "Pulseless electrical activity ": 3.031727869409328, "Radiotherapy ": 5.300263592362989, "Raynaud's phenomenon ": 2.0397808543979017, "Red blood cell transfusion ": 16.84039354442232, "Respiratory distress ": 2.4865160126474946, "Respiratory failure ": 10.225034400103748, "Respiratory syncytial virus infection ": 2.4661660381695563, "Respiratory tract infection ": 4.215746945787666, "Respiratory tract infection viral ": 8.63540280505277, "Resuscitation ": 9.112999858904097, "Rhinovirus infection ": 11.829268524495577, "Right ventricular dysfunction ": 19.92864815176336, "Right ventricular failure ": 136.42799760721908, "Right-to-left cardiac shunt ": 242.0200617494706, "Sarcoidosis ": 2.1001413990118114, "Scleroderma ": 38.12374010520422, "Seasonal allergy ": 2.364734917583493, "Sepsis ": 3.7257839710867375, "Septic shock ": 2.370700903992396, "Skin ulcer ": 3.500765816671256, "Staphylococcal infection ": 2.826765265686747, "Staphylococcal sepsis ": 2.4191864465016697, "Sudden cardiac death ": 5.055599712276701, "Sudden death ": 6.911537933427729, "Supraventricular tachycardia ": 2.076142069136613, "Surgery ": 2.725809193865039, "Systemic scleroderma ": 35.71621698934188, "Terminal state ": 15.756491734455532, "Therapy change ": 3.9962170262754384, "Therapy non-responder ": 2.2861668064969507, "Tracheostomy ": 17.597883895440866, "Transaminases increased ": 2.8910366288048164, "Transfusion ": 17.948926901163937, "Transplant ": 15.042368387265812, "Transplant evaluation ": 52.327285995031495, "Tricuspid valve incompetence ": 3.259277291880033, "Unevaluable event ": 2.724870025667716, "Upper respiratory tract infection ": 2.6020171756417327, "Urine output decreased ": 2.5096190737698203, "Vascular device infection ": 28.89979877487792, "Viral infection ": 3.599241436131178, "Walking distance test abnormal ": 68.62983098871018} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1091.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1091.json new file mode 100644 index 00000000000..82aefb54dfd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1091.json @@ -0,0 +1 @@ +{"Acute pulmonary oedema ": 303.8077193865649, "Anaemia neonatal ": 1509.8887549805152, "Atrial septal defect ": 85.01316955297854, "Bradycardia foetal ": 236.24926298570804, "Bradycardia neonatal ": 536.6381484931023, "Cardiac failure ": 4.61775533056901, "Chest discomfort ": 2.403972557655992, "Dyspnoea ": 2.9025549773361257, "Exposure during pregnancy ": 7.37755324372561, "Foetal death ": 90.95769082566837, "Foetal exposure during pregnancy ": 20.554724924786896, "Foetal growth restriction ": 83.26589431194269, "Hypotension ": 3.930304973608624, "Hypoxia ": 15.243559350458913, "Inguinal hernia ": 71.60826009645038, "Jaundice ": 8.924990547457472, "Low birth weight baby ": 155.90377936877294, "Maternal exposure during pregnancy ": 6.326833517989214, "Overdose ": 3.1146338112295417, "Pericardial effusion ": 11.84002971292918, "Pleural effusion ": 10.504424069460146, "Premature baby ": 118.04908072199056, "Premature labour ": 55.9556496487921, "Product use in unapproved indication ": 2.1359791425450263, "Pulmonary hypertension ": 24.30728274357121, "Pulmonary oedema ": 44.54722180397435, "Respiratory distress ": 9.164597783782272, "Tachycardia ": 2.490921032690599} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1092.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1092.json new file mode 100644 index 00000000000..d98a8788214 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1092.json @@ -0,0 +1 @@ +{"Chest pain ": 5.392860257938281, "Hypoglycaemia ": 32.592981874841975} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1093.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1093.json new file mode 100644 index 00000000000..60ac6bb919d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1093.json @@ -0,0 +1 @@ +{"Alopecia ": 2.6241823660695704, "Dermatitis ": 18.485370912065417, "Dermatitis acneiform ": 178.3444788149086, "Disease progression ": 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@@ -0,0 +1 @@ +{"Deafness ": 57.3306409342533, "Disease progression ": 55.143023382756525, "Lymphadenopathy ": 5.855002439232344, "Mantle cell lymphoma recurrent ": 4869.774588526102, "Off label use ": 6.148326864036193} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/110.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/110.json new file mode 100644 index 00000000000..3cbe9ee3306 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/110.json @@ -0,0 +1 @@ +{"Condition aggravated ": 7.384056038991352} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1100.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1100.json new file mode 100644 index 00000000000..9e26dfeeb6e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1100.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1101.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1101.json new file mode 100644 index 00000000000..1e22a7ecc0a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1101.json @@ -0,0 +1 @@ +{"Accidental overdose ": 2.6296123090845573, "Blood glucose abnormal ": 24.78087972701366, "Blood glucose decreased ": 21.925609170856852, "Blood glucose fluctuation ": 25.67302017667002, "Blood glucose increased ": 24.89259312866018, "Device breakage ": 19.875154519408607, "Device delivery system issue ": 33.96164898780047, "Device failure ": 20.80422867717287, "Device information output issue ": 99.2683663129178, "Device issue ": 16.856776104887295, "Device malfunction ": 15.91965837454006, "Diabetes mellitus inadequate control ": 27.95744980032748, "Diabetic ketoacidosis ": 16.455383706552617, "Diabetic retinopathy ": 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"White blood cell count increased ": 9.473695475307954} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1105.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1105.json new file mode 100644 index 00000000000..f8e14e1c7c2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1105.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 5.403626924150437, "Abortion spontaneous ": 2.1855466614040524, "Acute myocardial infarction ": 4.364114634545663, "Alanine aminotransferase increased ": 2.221817715406452, "Anxiety ": 2.5126702817908866, "Blood HIV RNA increased ": 94.5397674005564, "Blood creatinine increased ": 2.5162463048154478, "Chromaturia ": 2.6363422670054346, "Craniofacial fracture ": 16.00323880016695, "Cytomegalovirus infection ": 4.6028622834965125, "Depressed mood ": 4.915513682832467, "Depression ": 6.555983005847929, "Dermatitis allergic ": 3.777233281008909, 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2.173023630650995, "Metastases to bone ": 4.608094214969409, "Metastases to central nervous system ": 31.637125528548697, "Metastases to liver ": 11.124902332275592, "Metastases to lymph nodes ": 6.426408142046866, "Metastases to meninges ": 37.27705422132789, "Metastasis ": 15.85493451381507, "Mucosal inflammation ": 16.592205532591443, "Myelosuppression ": 2.1499986772095654, "Neuropathy peripheral ": 2.093165513027973, "Neutropenia ": 39.57906270834863, "Neutropenic colitis ": 264.3894184690821, "Neutropenic sepsis ": 34.953182777898256, "Neutrophil count abnormal ": 24.273228276241984, "Neutrophil count decreased ": 3.81623650104666, "Pancytopenia ": 4.168216564960286, "Pneumonitis ": 13.655155478146348, "Sepsis ": 2.5141180713781943, "Septic shock ": 5.297168415788171, "Stomatitis ": 2.156881394561052, "Therapy partial responder ": 9.699055877011729, "Thrombocytopenia ": 3.635663898143392, "Triple negative breast cancer ": 210.4750744130611} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1108.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1108.json new file mode 100644 index 00000000000..43a2ab68446 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1108.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.9599520689641263, "Abdominal distension ": 6.419063795242743, "Abdominal pain ": 3.620120907609257, "Abdominal pain upper ": 3.685588342464788, "Accidental overdose ": 2.658208553952218, "Accidental underdose ": 43.03843712659554, "Amylase increased ": 11.333830904616011, "Appetite disorder ": 2.1474708143991514, "Back disorder ": 2.1226926059458373, "Biliary colic ": 4.9969585461101165, "Blindness ": 2.665281332803318, "Blood glucose abnormal ": 10.467575420659744, "Blood glucose decreased ": 7.216397246987838, "Blood glucose fluctuation ": 2.718203392811243, "Blood glucose increased ": 10.073416218937318, "Blood triglycerides 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+++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1109.json @@ -0,0 +1 @@ +{"Loss of consciousness ": 26.50042158332387, "Syncope ": 22.356515565132643} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/111.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/111.json new file mode 100644 index 00000000000..8382ab04439 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/111.json @@ -0,0 +1 @@ +{"Anaemia ": 2.4003178637361526, "Chronic lymphocytic leukaemia ": 162.22256830834638, "Colectomy ": 120.38516549874858, "Colitis ": 12.539528052800083, "Death ": 2.532092513273746, "Disease progression ": 4.333681094365547, "Febrile neutropenia ": 4.572052119832367, "Flushing ": 4.12308805517138, "Gastrooesophageal reflux disease ": 5.681558831972588, "Hepatic steatosis ": 17.234922817130382, "Infection ": 2.7860159443706847, "Infusion related reaction ": 14.8457164984654, "Intestinal obstruction ": 19.9927447730106, "Neutropenia ": 6.518697438948528, "Pneumonia ": 4.458591296339398, "Respiratory tract infection ": 14.017825957177514, "Sepsis ": 10.319379780683096, "Sleep disorder ": 3.9228860020879495, "Urticaria ": 2.239608770618571} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1110.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1110.json new file mode 100644 index 00000000000..7a8d7441e95 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1110.json @@ -0,0 +1 @@ +{"Acute HIV infection ": 280.20277738887563, "Acute hepatitis C ": 27.41597793612541, "Acute kidney injury ": 3.787177161446794, "Albuminuria ": 2.169895356110505, "Anaemia of chronic disease ": 4.215352552502857, "Anhedonia ": 36.234057817902766, "Ankle fracture ": 15.434480687157956, "Anxiety ": 8.144784670968768, "Avulsion fracture ": 9.633760360102928, "Blood HIV RNA increased ": 5.4504545664058295, "Blood creatine increased ": 7.446884595025429, "Blood creatinine abnormal ": 7.110318382294442, "Blood creatinine increased ": 7.88866961075191, "Blood phosphorus decreased ": 6.338317095881918, "Bone demineralisation ": 46.45425171637221, "Bone density abnormal ": 41.5219315712452, "Bone density decreased ": 53.94310226682398, "Bone disorder ": 13.430547128528756, "Bone loss ": 68.51368227584163, "CD4 lymphocytes decreased ": 2.5722120246246014, "Cervical spinal stenosis ": 3.077848270211893, "Cervical vertebral fracture ": 3.1802554862285124, "Chronic kidney disease ": 45.10558066350288, "Chronic kidney disease-mineral and bone disorder ": 30.366109952556187, "Clavicle fracture ": 7.993901502456419, "Compression fracture ": 5.565300872796311, "Craniofacial fracture ": 5.097710488625307, "Creatinine renal clearance decreased ": 2.1369872937570418, "Decreased activity ": 6.27635512038181, "Degenerative bone disease ": 19.51880637956595, "Dental caries ": 4.4449558645243314, "Dysstasia ": 2.3740295489725467, "Economic problem ": 29.370968323767038, "Emotional distress ": 30.04732525117182, "End stage renal disease ": 26.42406254763668, "Fanconi syndrome ": 15.50414219497317, "Fanconi syndrome acquired ": 35.27945908165026, "Fear-related avoidance of activities ": 18.65184844518581, "Femoral neck fracture ": 2.394447525081536, "Femur fracture ": 4.541301329245099, "Fibula fracture ": 15.340182869365684, "Foot fracture ": 19.006097479218766, "Forearm fracture ": 12.351142054677586, "Fracture ": 25.590753011490605, "Fractured coccyx ": 3.232855366542165, "Fractured sacrum ": 6.520159988183859, "Gene mutation identification test positive ": 4.908400027954089, "Genotype drug resistance test positive ": 8.898345177071272, "Glomerular filtration rate abnormal ": 34.19553337255382, "Glomerular filtration rate decreased ": 5.544934713583113, "Glomerular filtration rate increased ": 19.96672116034269, "Glycosuria ": 5.991290921759968, "HIV infection ": 4.125121315088141, "HIV test positive ": 26.20451359067532, "Hand fracture ": 18.44578937706576, "Hepatitis B DNA increased ": 2.323754783340984, "Hip arthroplasty ": 6.418942258890757, "Hip fracture ": 6.635462243554665, "Humerus fracture ": 5.683795462987426, "Hypercreatinaemia ": 4.9373847004101705, "Hyperparathyroidism ": 4.462040415720573, "Hyperparathyroidism secondary ": 12.64441609693646, "Hyperphosphataemia ": 2.016318942228509, "Hyperphosphaturia ": 13.416712855848262, "Hypophosphataemia ": 4.832732673545217, "Immune reconstitution inflammatory syndrome ": 6.012529462054437, "Immune reconstitution inflammatory syndrome associated Kaposi's sarcoma ": 10.352984520321906, "Immune reconstitution inflammatory syndrome associated tuberculosis ": 6.891947290869579, "Intervertebral disc degeneration ": 6.447042394555401, "Intervertebral disc space narrowing ": 5.99790697712559, "Jaw fracture ": 12.156778381114195, "Joint arthroplasty ": 5.742276368623741, "Kidney enlargement ": 2.1221588922214827, "Kidney fibrosis ": 3.869070493460961, "Limb fracture ": 17.986323589381943, "Loss of personal independence in daily activities ": 2.090275867570981, "Lower limb fracture ": 6.635368640602052, "Lumbar spinal stenosis ": 2.290670895721512, "Lumbar vertebral fracture ": 5.651228708380304, "Multiple fractures ": 66.22581992318202, "Nephrogenic anaemia ": 8.653046718866833, "Nephrolithiasis ": 2.6810816813972003, "Nephropathy ": 29.879319102877165, "Osteoarthritis ": 4.618559494639511, "Osteochondrosis ": 2.885117636957224, "Osteomalacia ": 27.71823713318533, "Osteonecrosis ": 60.90031088752984, "Osteopenia ": 39.595588742731046, "Osteoporosis ": 44.003572877467015, "Osteoporotic fracture ": 19.467346146552988, "Pain ": 3.657662426043725, "Partner stress ": 4.124631218771299, "Patella fracture ": 6.244898346236188, "Pathological fracture ": 4.969325355061479, "Pelvic fracture ": 3.904356311281637, "Periodontal 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3.618436779042909, "Shoulder fracture ": 9.612681412791336, "Sitting disability ": 3.3138221009016453, "Skeletal injury ": 44.38344892571856, "Spinal compression fracture ": 7.638610200442364, "Spinal fracture ": 6.203822384936808, "Spinal osteoarthritis ": 6.650934553243771, "Sternal fracture ": 2.4495776499485835, "Stress fracture ": 2.8758305028396043, "Syphilis ": 4.282063284253092, "Teeth brittle ": 13.802859350777782, "Thoracic vertebral fracture ": 2.7155758793026887, "Tibia fracture ": 16.57487096589126, "Tooth extraction ": 4.667684666002426, "Tooth fracture ": 16.45140878548545, "Tooth loss ": 42.11848744358908, "Ulna fracture ": 9.286609988380077, "Upper limb fracture ": 7.461123161694659, "Vertebral foraminal stenosis ": 6.783656917901483, "Viral load increased ": 4.756791089592164, "Vitamin D deficiency ": 16.546395533804326, "Wrist fracture ": 13.115803347275715} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1111.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1111.json new file mode 100644 index 00000000000..02194945705 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1111.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 7.50659740576162} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1112.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1112.json new file mode 100644 index 00000000000..0bfd8b211c6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1112.json @@ -0,0 +1 @@ +{"Unevaluable event ": 62.01537255047938} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1113.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1113.json new file mode 100644 index 00000000000..4a4f5dc5027 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1113.json @@ -0,0 +1 @@ +{"Abdominal symptom ": 26.63895069127133, "Acute disseminated encephalomyelitis ": 12.709154182156484, "Allergy to metals ": 31.208132785762515, "Areflexia ": 6.4112930980695575, "Autoimmune disorder ": 2.7644421847759544, "Autoimmune hepatitis ": 4.255827910464643, "Autoimmune thyroiditis ": 10.214820989657216, "Bedridden ": 2.017999925391984, "Chromaturia ": 2.3549682693385887, "Chronic fatigue syndrome ": 13.039041357385424, "Circulatory collapse ": 7.181063100685838, "Coordination abnormal ": 3.5286366255105928, "Demyelination ": 7.087642895744789, "Dermatitis allergic ": 2.642929518840741, "Diarrhoea haemorrhagic ": 2.595402375200736, "Diplopia ": 2.0188113571126785, "Disability ": 4.081461293896608, "Disturbance in attention ": 2.025098108605542, "Dysaesthesia ": 5.055151893154581, "Eczema ": 2.5250214162206124, "Encephalitis ": 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2.4071361649815284, "Oedema peripheral ": 12.1722214162604} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1115.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1115.json new file mode 100644 index 00000000000..b41e83b9f93 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1115.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 4.634730624503439, "Clostridium difficile colitis ": 59.760479895785295, "Diarrhoea ": 2.3042208419744674, "Hepatic enzyme increased ": 7.505495467581143, "Off label use ": 3.511937579469737, "Platelet count decreased ": 10.254892277622377, "Thrombocytopenia ": 6.943590077047926} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1116.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1116.json new file mode 100644 index 00000000000..49132c2cac6 --- /dev/null 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incomplete ": 25.33617825864877, "Therapeutic response decreased ": 5.102463532025023, "Wheezing ": 27.58890843966702} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1119.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1119.json new file mode 100644 index 00000000000..1713fa56c31 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1119.json @@ -0,0 +1 @@ +{"Cardio-respiratory arrest ": 37.14500927552841, "Completed suicide ": 31.485302076391086, "Death ": 5.054482790600991, "Drug abuse ": 2.931927045546745, "Drug eruption ": 9.09065494289497, "Drug interaction ": 4.422705855266978, "Drug-induced liver injury ": 5.650622068051613, "Intentional overdose ": 4.922599400571227, "Intentional product misuse ": 8.231470919708164, "Loss of consciousness ": 2.245824837892662, "Overdose ": 2.1465761918483364, "Respiratory arrest ": 7.437398555243909, "Stevens-Johnson syndrome ": 6.515991760576148, "Suicide attempt ": 3.3268348105228718, "Toxicity to various agents ": 10.683844269619724} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/112.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/112.json new file mode 100644 index 00000000000..07b78be1192 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/112.json @@ -0,0 +1 @@ +{"Cardiomyopathy ": 32.10236724451382, "Completed suicide ": 20.8823279788017, "Constipation ": 2.912677411857183, "Drug abuse ": 17.210980663496287, "Electrocardiogram QT prolonged ": 8.588262012059259, "Hypotension ": 3.8470542251340887, "Intentional overdose ": 8.797260050481878, "Mental impairment ": 26.26973011913314, "Microcytosis ": 2486.398161409357, "Neuroleptic malignant syndrome ": 19.97782218049421, "Overdose ": 6.218184290427175, "Pulmonary oedema ": 24.880606769870635, "Sedation ": 18.927634474977687, "Somnolence ": 2.202478123483944, "Toxicity to various agents ": 24.842176364235915} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1120.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1120.json new file mode 100644 index 00000000000..06cb563f961 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1120.json @@ -0,0 +1 @@ +{"Cardiac arrest ": 19.10424750165365, "Cardio-respiratory arrest ": 59.97668216800808, "Completed suicide ": 70.40448377862401, "Death ": 8.133131237001775, "Drug abuse ": 11.469858188622805, "Drug interaction ": 3.4856871677443837, "Gastritis ": 5.724904094990235, "Gastrooesophageal reflux disease ": 2.091701002418026, "Intentional overdose ": 4.52359954519825, "Intentional product misuse ": 13.814003587134271, "Medication error ": 4.277647757322662, "Overdose ": 8.639218236813234, "Product administration error ": 5.682825623944992, "Respiratory arrest ": 57.9486603798576, "Suicide attempt ": 3.84377613574144, "Toxicity to various agents ": 2.748323064287948} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1121.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1121.json new file mode 100644 index 00000000000..1825e905616 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1121.json @@ -0,0 +1 @@ +{"Acne ": 118.97330193862942, "Alanine aminotransferase increased ": 2.0501458018937315, "Blood creatine phosphokinase increased ": 15.949778588386271, "Colitis ulcerative ": 6.332032557249201, "Deep vein thrombosis ": 3.000820755386802, "Dermatitis atopic ": 63.92018175252005, "Eczema herpeticum ": 420.7021269661533, "Herpes zoster ": 8.289182462460916, "Lipids increased ": 105.97899889350984, "Off label use ": 6.630244744426442, "Oral herpes ": 14.211142165000236, "Product 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1123.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1123.json new file mode 100644 index 00000000000..6c3a9a2fb3a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1123.json @@ -0,0 +1 @@ +{"Diarrhoea ": 2.3992783814738616, "Dizziness ": 3.805618341467909, "Dry mouth ": 14.863619091422716, "Ejaculation delayed ": 278.87763042882534, "Ejaculation disorder ": 182.75982508068552, "Ejaculation failure ": 1366.275005441801, "Erectile dysfunction ": 44.1891832651713, "Fall ": 2.663681338001544, "Gynaecomastia ": 16.825726505283956, "Hypotension ": 3.039503403256823, "Intentional product use issue ": 3.586827280680069, "Libido decreased ": 34.48602214236978, "Nasal congestion ": 46.89901844546527, "Orthostatic hypotension ": 29.556927954910908, "Presyncope ": 4.319022426315292, "Pruritus ": 2.070639017654329, "Rash papular ": 9.14669405834788, "Retrograde 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1125.json new file mode 100644 index 00000000000..f393bb3e6bc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1125.json @@ -0,0 +1 @@ +{"Agitation ": 2.680986286067177, "Alanine aminotransferase increased ": 4.613056624396, "Anxiety ": 2.00040030589495, "Aspartate aminotransferase increased ": 3.3985174221568166, "Coma ": 5.05407652742842, "Depression ": 3.380313793476107, "Disorientation ": 7.018722659935164, "Drug interaction ": 4.52546877731131, "Dysarthria ": 6.116331297362772, "Gamma-glutamyltransferase increased ": 10.651416251477333, "Hyperhidrosis ": 2.433444165727105, "Insomnia ": 2.002242225988651, "Intentional overdose ": 30.09070341614108, "Jaundice ": 4.325328430327815, "Mydriasis ": 20.69534154483875, "Restlessness ": 15.997917929639424, "Sedation ": 9.698695654328173, "Serotonin syndrome ": 16.484636612791757, "Sleep disorder ": 3.110988763167674, "Somnolence ": 6.722082735964027, "Suicidal ideation ": 3.434444399055876, "Suicide attempt ": 21.262379493595496, "Tachycardia ": 2.6008157514615013, "Tremor ": 2.8932874883865334} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1126.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1126.json new file mode 100644 index 00000000000..de5c4e96947 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1126.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.153421264047847, "Angioedema ": 3.918305752864459, "Atrial fibrillation ": 2.922900005109394, "Blood creatinine increased ": 7.221032473508703, "Blood potassium decreased ": 5.013963098025278, "Blood potassium increased ": 21.191445945582103, "Blood pressure abnormal ": 5.105777875797806, "Blood pressure decreased ": 14.610005851876169, "Blood pressure diastolic decreased ": 14.340032255750485, "Blood pressure fluctuation ": 10.071686878996095, "Blood pressure inadequately controlled ": 39.216790828152185, "Blood pressure increased ": 5.348806419371984, "Blood pressure systolic increased ": 3.873286406434437, "Blood urea increased ": 6.219175477943817, "Cardiac failure ": 8.19735253272758, "Cardiac failure chronic ": 66.99707054268391, "Cardiogenic shock ": 4.632575611042719, "Cardiomegaly ": 4.300357683712462, "Colorectal cancer ": 2.0160414758573206, "Diabetes mellitus ": 3.10409808225989, "Dilated cardiomyopathy ": 17.279783813971164, "Dizziness ": 2.4139221138168327, "Ejection fraction decreased ": 25.86129382237018, "Exercise tolerance decreased ": 4.891973175554948, "Glomerular filtration rate decreased ": 12.168385066272046, "Heart rate decreased ": 7.104071597069544, "Hepatic function abnormal ": 2.728084937821881, "Hyperkalaemia ": 22.42117994810287, "Hypertension ": 3.947212109297526, "Hypotension ": 20.038336711355612, "Hypotonia ": 5.939150000865812, "Inappropriate schedule of product 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": 4.55760357703481, "Tricuspid valve incompetence ": 8.21231645732534, "Underdose ": 12.660336688721776, "Urine output decreased ": 8.510387614986618, "Ventricular hypokinesia ": 24.023510920868613, "Ventricular tachycardia ": 5.62074393667376, "Wrong technique in product usage process ": 11.534293420904335} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1127.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1127.json new file mode 100644 index 00000000000..15eb37dcdd5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1127.json @@ -0,0 +1 @@ +{"Drug ineffective ": 14.822806754746676, "Drug ineffective for unapproved indication ": 179.0166295612363, "Off label use ": 10.704645331921489} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1128.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1128.json new file mode 100644 index 00000000000..8c794e48397 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1128.json @@ -0,0 +1 @@ +{"Diarrhoea ": 2.817387163725226, "Electrocardiogram QT prolonged ": 28.364739606665385} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1129.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1129.json new file mode 100644 index 00000000000..2d93171aecd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1129.json @@ -0,0 +1 @@ +{"Off label use ": 13.726960732971587} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/113.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/113.json new file mode 100644 index 00000000000..f40b73f8f8a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/113.json @@ -0,0 +1 @@ +{"Abdominal tenderness ": 5.133888882265375, "Abscess bacterial ": 430.01279390507, "Abscess fungal ": 181.2853996352168, "Activated partial thromboplastin time prolonged ": 3.2819947731632566, "Acute graft versus host disease in skin ": 5.158804254737412, "Acute lymphocytic leukaemia ": 42.91349536039485, "Acute lymphocytic leukaemia recurrent ": 75.60729679708479, "Acute myeloid leukaemia ": 6.873000715560991, "Acute respiratory distress syndrome ": 2.955839166215123, "Adenovirus infection ": 9.183100393507374, "Alanine aminotransferase increased ": 2.427576404015586, "Altered state of consciousness ": 2.185810600706365, "Ammonia increased ": 4.166168267425813, "Amylase increased ": 15.8399167838061, "Anal stenosis ": 241.2498489251392, "Anaphylactoid reaction ": 2.073248773058864, "Angiocentric lymphoma ": 319.67728143141954, "Antithrombin III decreased ": 121.48788414995752, "Aplastic anaemia ": 10.132184254094309, "Ascites ": 2.9117593433638747, "Aspartate aminotransferase increased ": 2.2330382872602685, "Aspergillus infection ": 46.20120275181276, "Atrial septal defect ": 5.094021886965418, "B-cell lymphoma ": 8.670192031147167, "BK virus infection ": 11.791158140462096, "Bacillus test positive ": 276.1900724893627, "Bacteraemia ": 8.94642099772847, "Bacterial infection ": 54.875844041382486, "Bacterial sepsis ": 9.318117569831845, "Bacterial translocation ": 94.27717341224188, "Bilirubin conjugated increased ": 13.61118293712399, "Blast cells present ": 35.1839188335527, "Blood albumin decreased ": 3.48755324015512, "Blood alkaline phosphatase increased ": 3.5001837360849595, "Blood bilirubin increased ": 5.86583937435927, "Blood culture positive ": 13.16169259847029, "Blood fibrinogen decreased ": 17.833106748120954, "Blood growth hormone decreased ": 111.96591464873758, "Blood lactate dehydrogenase increased ": 2.303101354047261, "Blood triglycerides increased ": 2.518795643407307, "Bone marrow failure ": 11.413029748863606, "Brain oedema ": 2.65165890841649, "Bronchopulmonary aspergillosis ": 82.87104268526888, "Cafe au lait spots ": 409.5982213616621, "Candida infection ": 5.918117277077505, "Cardiac ventricular thrombosis ": 33.34410310302302, "Cardiomyopathy ": 2.0773390698575485, "Cardiotoxicity ": 9.010791390349253, "Cellulitis ": 5.528754799572482, "Central hypothyroidism ": 107.35954956553772, "Cerebral cavernous malformation ": 478.4146558212937, "Cerebral haemorrhage ": 2.0193093812864915, "Cerebral ischaemia ": 7.932030498237815, "Cerebral thrombosis ": 10.171756413196482, "Cerebral venous sinus thrombosis ": 13.79892204589274, "Cerebral venous thrombosis ": 68.8207715845906, "Cholestasis ": 4.655123164463696, "Chronic graft versus host disease ": 13.37380877133634, "Chronic sinusitis ": 13.991273260565896, "Clostridium difficile colitis ": 29.462351886900432, "Clostridium difficile infection ": 5.586361099615156, "Coagulopathy ": 7.293560142298391, "Coma hepatic ": 16.583530976311824, "Congenital anomaly ": 5.850741515615895, "Coronavirus infection ": 19.581115861660333, "Cryptorchism ": 34.921023865416814, "Cystitis ": 7.2690700648376225, "Cystitis bacterial ": 710.7920020275193, "Cystitis haemorrhagic ": 6.655472784189851, "Cytomegalovirus chorioretinitis ": 50.82124813042773, "Cytomegalovirus infection ": 3.870452423293704, "Cytomegalovirus viraemia ": 42.33850662187424, "Cytopenia ": 5.341708217348028, "Dacryostenosis acquired ": 43.55443140879772, "Developmental hip dysplasia ": 49.03196797447769, "Device related bacteraemia ": 39.01901747401963, "Device related infection ": 2.736999805130599, "Diffuse alveolar damage ": 115.37471484915706, "Dilated cardiomyopathy ": 5.250312001542403, "Disseminated aspergillosis ": 490.1458222658583, "Disseminated intravascular coagulation ": 4.76279941265032, "Disseminated mucormycosis ": 79.74362905613967, "Drug clearance decreased ": 41.24009998524599, "Drug hypersensitivity ": 2.3654487674411824, "Drug interaction ": 2.0734979320396865, "Ear malformation ": 70.36201745381456, "Ejection fraction decreased ": 2.19611041313432, "Electroencephalogram abnormal ": 13.85665644314401, "Embolism venous ": 10.76203789058176, "Emotional disorder ": 3.212743310736533, "Enamel anomaly ": 73.1880328359359, "Encephalitis ": 18.74000560066149, "Encephalopathy ": 4.697313980582321, "Enteritis ": 37.05199396358634, "Enterobacter infection ": 278.03534902497915, "Enterococcal infection ": 19.15116955114026, "Epilepsy ": 2.3727635501806965, "Eschar ": 25.75877048984337, "Escherichia infection ": 7.496196773771023, "Escherichia sepsis ": 8.326581465317668, "Ewing's sarcoma ": 97.80940640266805, "Febrile neutropenia ": 23.878899281226914, "Foetal distress syndrome ": 14.7398836433327, "Fournier's gangrene ": 3.75999569342926, "Fungaemia ": 18.50180720157124, "Fungal infection ": 16.987797997497495, "Fusarium infection ": 23.475407961537847, "Gastroenteritis norovirus ": 96.65176109842196, "Gastrointestinal necrosis ": 6.965564877225422, "Gastrointestinal perforation ": 4.69816200492505, "Gastrointestinal protozoal infection ": 561.9550542438122, "Generalised tonic-clonic seizure ": 2.338732252311187, "Glioblastoma multiforme ": 76.12593055161321, "Graft versus host disease ": 8.361455674225297, "Growth hormone deficiency ": 42.254489806209534, "Haemangioma ": 22.35483115503358, "Haematotoxicity ": 39.7439864866309, "Haemorrhage intracranial ": 2.268977166156065, "Hemiparesis ": 2.663729352423599, "Hepatic encephalopathy ": 5.06722416348333, "Hepatic failure ": 2.305920437185893, "Hepatic lesion ": 4.453349404255383, "Hepatic steatosis ": 9.348567678525148, "Hepatomegaly ": 6.178761764269764, "Hepatosplenomegaly ": 8.363037532467885, "Hepatotoxicity ": 11.069979152498458, "Herpes simplex ": 4.361995427065136, "Hippocampal sclerosis ": 167.13486459068065, "Human bocavirus infection ": 1957.7473921606545, "Human herpesvirus 6 infection ": 269.4510624146874, "Hyperammonaemia ": 8.296364388840908, "Hyperammonaemic encephalopathy ": 8.295920821338791, "Hyperbilirubinaemia ": 9.86978245559182, "Hyperglycaemia ": 3.2303632958598945, "Hyperlipidaemia ": 6.827131841990698, "Hyperplasia ": 43.44421060422945, "Hypersensitivity ": 2.0417621182635104, "Hypertransaminasaemia ": 5.421282670953528, "Hypertriglyceridaemia ": 39.53357680926413, "Hypoalbuminaemia ": 6.487132446655406, "Hypofibrinogenaemia ": 23.917903852160908, "Hypophagia ": 3.478961303036884, "Hyporeflexia ": 7.198618205930351, "Ileus ": 4.122709627905447, "Ileus paralytic ": 9.51751603334407, "Immune reconstitution inflammatory syndrome ": 2.080511778153732, "Inappropriate antidiuretic hormone secretion ": 8.68460498726035, "Inguinal hernia ": 11.00472420069494, "Intracranial pressure increased ": 6.028169170140573, "Jaundice ": 2.2099360541617314, "Jaundice cholestatic ": 3.580166422718817, "Kidney duplex ": 287.64491534754814, "Klebsiella infection ": 7.15072821700264, "Klebsiella sepsis ": 42.801394379308704, "Lennox-Gastaut syndrome ": 252.46334778932453, "Leptotrichia infection ": 629.9935959036418, "Leukaemia ": 3.2715742746403347, "Leukaemia recurrent ": 39.38746816765458, "Leukoencephalopathy ": 20.430810276701774, "Lip oedema ": 2.200092581512791, "Lipase increased ": 7.399089291530031, "Liver abscess ": 9.19155590411931, "Low birth weight baby ": 4.746422462442229, "Lymphangitis ": 10.827097929273894, "Lymphoid tissue hypoplasia ": 3440.467664101077, "Lymphoma ": 2.085845204885646, "Lymphopenia ": 10.253602836845584, "Magnetic resonance imaging head abnormal ": 15.214867007330565, "Malnutrition ": 3.4388681663165293, "Mental status changes ": 2.221652374359274, "Motor developmental delay ": 65.92066238831329, "Motor dysfunction ": 2.0277978531552314, "Mucormycosis ": 67.07912415846083, "Mucosal inflammation ": 6.362803053901457, "Multiple organ dysfunction syndrome ": 6.308935013096033, "Mycobacterium chelonae infection ": 560.566896846649, "Myelopathy ": 12.887382671684607, "Myelosuppression ": 3.414780689926144, "Myopathy ": 3.482507513095783, "Neoplasm recurrence ": 15.05486522354311, "Neurotoxicity ": 14.2011200632041, "Neutropenia ": 4.752217137987931, "Neutropenic colitis ": 35.58110644337845, "Neutropenic sepsis ": 11.001427394410594, "Non-alcoholic steatohepatitis ": 14.418405644262846, "Norovirus test positive ": 731.7837258096637, "Oesophageal candidiasis ": 31.79229053316334, "Oral herpes ": 11.192740755611666, "Overweight ": 12.29160763943474, "Pancreatic pseudocyst ": 119.01717524869828, "Pancreatitis ": 5.427743888188936, "Pancreatitis acute ": 13.164815233504898, "Pancreatitis necrotising ": 36.922295647503525, "Pancytopenia ": 3.876722608542614, "Panniculitis ": 4.642960968138163, "Papilloedema ": 3.28688134670332, "Parainfluenzae virus infection ": 231.63485125133508, "Paranasal sinus mucosal hypertrophy ": 203.17410242714985, "Partial seizures ": 7.125067755412741, "Peripheral motor neuropathy ": 13.408992819907525, "Peripheral sensory neuropathy ": 3.4635638025119397, "Peritonitis ": 2.3044057099609327, "Phimosis ": 26.63528147586704, "Pleuritic pain ": 4.9786162063403, "Pneumatosis intestinalis ": 113.87109256001396, "Pneumocystis jirovecii pneumonia ": 2.80990899806932, "Pneumonia fungal ": 17.05388200448535, "Posterior reversible encephalopathy syndrome ": 60.56914711338992, "Posture abnormal ": 17.641828859563073, "Prothrombin time prolonged ": 2.426664609599449, "Pseudomonal sepsis ": 319.775220112462, "Pseudomonas infection ": 12.415466277968063, "Pulmonary haemorrhage ": 6.85738638256523, "Pulmonary valve stenosis ": 40.59039606917415, "Pulse absent ": 3.5508766527768394, "Pyelocaliectasis ": 62.71274736489988, "Pyomyositis ": 56.19290957740202, "Renal mass ": 11.9801263927708, "Renal tubular necrosis ": 2.8616712700174745, "Rhinorrhoea ": 2.687526536131911, "Rhinovirus infection ": 102.53648638889446, "Scrotal infection ": 136.08489480916026, "Scrotal oedema ": 22.04026547274284, "Second primary malignancy ": 11.1642737739218, "Secondary immunodeficiency ": 776.0485639878335, "Seizure ": 2.039071835867569, "Sepsis ": 6.1798630716004, "Septic shock ": 9.60473461836865, "Sinusitis fungal ": 34.31395774472666, "Staphylococcal bacteraemia ": 16.095596665461926, "Staphylococcal infection ": 6.086755783066449, "Stenotrophomonas infection ": 18.551315214788676, "Steroid diabetes ": 12.635004786601137, "Stomatitis ": 3.141583824361632, "Superior sagittal sinus thrombosis ": 110.17746461657556, "Systemic candida ": 9.784858006065411, "Systemic mycosis ": 18.281829632326176, "T-cell type acute leukaemia ": 96.109955574952, "Tachypnoea ": 2.87409645787383, "Temporal lobe epilepsy ": 137.07824227255696, "Thymus hypoplasia ": 2467.4379959956373, "Tooth hypoplasia ": 110.99681463570089, "Transverse sinus thrombosis ": 29.499874221664477, "Tumour lysis syndrome ": 10.972282079807687, "Type 1 diabetes mellitus ": 2.793739560365604, "Venoocclusive disease ": 11.276923933617104, "Venoocclusive liver disease ": 59.22517512303188, "Venous thrombosis ": 17.490025553375926, "Venous thrombosis limb ": 3.6051049870984873, "Viraemia ": 119.14962675355363, "Viral haemorrhagic cystitis ": 20.089670572403808, "Viral infection ": 27.161805730258617} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1130.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1130.json new file mode 100644 index 00000000000..b9fc69c6bff --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1130.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 24.92171622127777, "Aggression ": 4.815008733020612, "Agitation ": 5.759763586746183, "Anger ": 9.479165282595376, "Anxiety ": 2.288763329920857, "Asthma ": 5.304440306669286, "Completed suicide ": 4.595000183765949, "Condition aggravated ": 3.427877759909617, "Cough ": 2.592262691008745, "Depressed mood ": 14.701112476663232, "Depression ": 5.596001388417595, "Drug-induced liver injury ": 3.2120497651936293, "Dyspepsia ": 2.020503727977837, "Eosinophil count decreased ": 178.9103912301595, "Eosinophil count increased ": 26.621213362331087, "Full blood count abnormal ": 19.295760722661964, "Gastrooesophageal reflux disease ": 10.233667434335215, "Insomnia ": 3.577180527438575, "Irritability ": 9.441155517020963, "Loss of personal independence in daily activities ": 8.131251014982976, "Mania ": 16.873937286848534, "Mood altered ": 7.970782773944391, "Mood swings ": 15.749139610367603, "Nasal obstruction ": 213.2398847970452, "Nightmare ": 6.521673110084333, "Paranoia ": 11.530650983975736, "Productive cough ": 14.740983499543688, "Psychotic disorder ": 8.623899064165924, "Sinusitis ": 12.125655844010716, "Sleep disorder ": 4.82867831410423, "Sleep disorder due to a general medical condition ": 31.60622341915452, "Suicidal ideation ": 12.380166911804343, "Suicide attempt ": 3.321872733562656, "Therapeutic product effect incomplete ": 7.740702146711989, "Throat clearing ": 251.59142101064495, "Treatment noncompliance ": 18.98929197707808, "Upper-airway cough syndrome ": 128.9794377523192, "Vomiting ": 2.05581293590363} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1131.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1131.json new file mode 100644 index 00000000000..ef7aa515287 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1131.json @@ -0,0 +1 @@ +{"Cough ": 4.6474506586541455, "Febrile convulsion ": 276.5031654646899, "Seizure ": 7.04383688745487} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1132.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1132.json new file mode 100644 index 00000000000..e9c635e1c1e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1132.json @@ -0,0 +1 @@ +{"Abnormal faeces ": 2.902137949982365, "Acute macular neuroretinopathy ": 3.355011501588046, "Administration site erythema ": 5.1306671196848495, "Administration site hypersensitivity ": 11.701142339144964, "Administration site oedema ": 6.205664932106696, "Administration site pain ": 6.621046934471762, "Administration site reaction ": 2.631533826863067, "Antibody test ": 25.21322444761289, "Antibody test abnormal ": 2.871654462789048, "Antibody test negative ": 3.5645009405434225, "Aortic thrombosis ": 2.153995138068192, "Application site haematoma ": 2.025762746033165, "Application site induration ": 2.7826950218070405, "Application site oedema ": 4.4541578092943865, "Arthralgia ": 2.197046869192503, "Blood fibrinogen increased ": 3.1328476950571247, "Blood pressure measurement ": 2.0452379851995324, "Body temperature ": 3.329747324983579, "Body temperature abnormal ": 3.1710252156394705, "Body temperature increased ": 5.30272117020829, "Body temperature normal ": 10.53434977722905, "Bone pain ": 2.4235343511251, "COVID-19 ": 5.04901041303239, "Capillary fragility ": 2.6565024752590003, "Cerebral thrombosis ": 2.8302999226450063, "Cerebral venous sinus thrombosis ": 7.739945463712981, "Cerebral venous thrombosis ": 3.711956903363014, "Chills ": 5.067167443898866, "Chronic inflammatory demyelinating polyradiculoneuropathy ": 2.3128865262281417, "Encephalomyelitis ": 2.0005163309644427, "Eye haematoma ": 3.9791338003504406, "Eye infarction ": 2.495316970181389, "Eye pain ": 2.3517328425613084, "Eyelid bleeding ": 2.84660536404007, "Eyelid haematoma ": 2.5615433601999325, "Facial discomfort ": 2.7881145802158858, "Fatigue ": 2.073003138679596, "Feeling cold ": 3.4955518953651383, "Feeling hot ": 2.6420538197061214, "Feeling of body temperature change ": 2.359910113607084, "Fibrin D dimer ": 2.706868407105405, "Fibrin D dimer increased ": 3.8280514111739983, "Guillain-Barre syndrome ": 4.132908539748054, "Haemorrhoids thrombosed ": 5.0012562282893, "Head discomfort ": 2.2804921186881777, "Headache ": 3.4656336201849878, "Hemiparaesthesia ": 2.688403272577601, "Heparin-induced thrombocytopenia test positive ": 9.700509811932166, "Hepatic vein thrombosis ": 5.532758799183539, "Hyperaesthesia ": 2.5837965819208826, "Hyperpyrexia ": 2.2518243496536856, "Hypotonia ": 2.7827117143086797, "Incomplete course of vaccination ": 4.794000916064215, "Influenza ": 5.332203974936432, "Influenza like illness ": 4.832881116230317, "Injection site indentation ": 2.347435910299344, "Injection site joint movement impairment ": 3.302547569540732, "Injection site joint pain ": 2.7323034413300613, "Injection site movement impairment ": 4.166269309341488, "Injection site muscle weakness ": 2.011286529984275, "Injection site pain ": 2.215580468971463, "Injection site reaction ": 4.563089401631374, "Jugular vein thrombosis ": 2.3607087248814063, "Labour pain ": 2.405751919591685, "Limb discomfort ": 6.218275209524858, "Local reaction ": 5.362385642871577, "Locomotive syndrome ": 11.810765173396954, "Meningism ": 2.194724300455667, "Mesenteric vein thrombosis ": 2.391820014825808, "Miller Fisher syndrome ": 2.725949081506543, "Myalgia ": 3.301187984473398, "Myelin oligodendrocyte glycoprotein antibody-associated disease ": 3.867124625981779, "Myelitis transverse ": 2.4969514427769828, "New daily persistent headache ": 2.512091163881199, "Nuchal rigidity ": 2.391493760990039, "Ocular discomfort ": 2.284555869215628, "Ophthalmic vein thrombosis ": 4.920479557366775, "Oral contusion ": 2.4642960792907016, "Oxygen saturation ": 6.246853154745332, "Pain in extremity ": 2.8143827402669164, "Pain of skin ": 2.1876963627845334, "Periorbital haemorrhage ": 2.121937026479123, "Peripheral artery thrombosis ": 2.872970538658464, "Peripheral circulatory failure ": 3.2247585286041778, "Peripheral coldness ": 2.170845432192784, "Peripheral vascular disorder ": 3.805579469567367, "Petechiae ": 3.155442149391035, "Phlebitis superficial ": 3.556748867896201, "Polymerase chain reaction positive ": 2.1368049224706964, "Portal vein thrombosis ": 2.553698747838306, "Portosplenomesenteric venous thrombosis ": 6.315673624353204, "Pulmonary pain ": 2.1810521136909298, "Pyrexia ": 4.145350589224831, "Respiratory depth decreased ": 2.4642960792907016, "Rest regimen ": 3.5041590465242423, "Retinal vascular thrombosis ": 2.975279801206809, "Retinal vein thrombosis ": 2.345155594627615, "Reversed hot-cold sensation ": 3.434087229227952, "SARS-CoV-2 antibody test ": 5.869045099237156, "SARS-CoV-2 antibody test negative ": 4.4332254516051215, "SARS-CoV-2 test negative ": 5.015705715630027, "SARS-CoV-2 test positive ": 4.204660628264038, "Sacral pain ": 2.388434177670164, "Sensory disturbance ": 2.476252389051451, "Sensory level abnormal ": 2.902059267636366, "Severe acute respiratory syndrome ": 31.205225252261773, "Shoulder injury related to vaccine administration ": 2.180484506073059, "Sigmoid sinus thrombosis ": 16.215536244593206, "Splenic vein thrombosis ": 2.1277878191710213, "Sudden cardiac death ": 2.194880899304029, "Superficial vein prominence ": 4.7301865873292455, "Superficial vein thrombosis ": 4.312305411734791, "Superior sagittal sinus thrombosis ": 3.813193723787341, "Tenderness ": 2.279778543409945, "Thrombolysis ": 2.767703360290368, "Thrombophlebitis ": 3.074054912604828, "Thrombosis mesenteric vessel ": 2.728329918163163, "Thrombosis with thrombocytopenia syndrome ": 50.984197369119926, "Transverse sinus thrombosis ": 6.056609635218309, "Vaccination failure ": 6.005217261560954, "Vaccination site atrophy ": 9.097066043231184, "Vaccination site bruising ": 3.5712418496683846, "Vaccination site discomfort ": 13.939786945130258, "Vaccination site haematoma ": 7.978883126163369, "Vaccination site hyperaesthesia ": 2.081970808558284, "Vaccination site hypersensitivity ": 7.566582122434965, "Vaccination site 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1133.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1133.json new file mode 100644 index 00000000000..8c1ca44c29e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1133.json @@ -0,0 +1 @@ +{"Acne ": 7.180639476509835, "Blood magnesium decreased ": 23.500793987521423, "Cerebral infarction ": 2.0934559341406835, "Colon cancer ": 76.09850701164986, "Colorectal cancer metastatic ": 188.6553068742261, "Conjunctivitis ": 13.375080194716892, "Decreased appetite ": 2.19750841807612, "Dermatitis ": 7.497178450670846, "Dermatitis acneiform ": 447.14163840948726, "Diarrhoea ": 2.542156724671877, "Disease progression ": 10.148890727768045, "Dry skin ": 12.709833565517892, "Erythema ": 2.259089108996288, "Febrile neutropenia ": 3.869850089455552, "Folliculitis ": 4.164078951846105, "Gastrointestinal perforation ": 16.415169105565433, "Gastrointestinal toxicity ": 26.317986804612485, "Haematotoxicity ": 20.76880639419742, "Hypocalcaemia ": 8.870293595804027, "Hypomagnesaemia ": 171.51108215756383, "Infusion related reaction ": 3.268563738025764, "Interstitial lung disease ": 25.11126217969301, "Leukopenia ": 2.432230712818792, "Metastases to liver ": 19.326109349843605, "Metastases to lung ": 8.126174606056066, "Mucosal inflammation ": 9.803165973594096, "Myelosuppression ": 2.773139160113045, "Neuropathy peripheral ": 20.40657767676965, "Neurotoxicity ": 23.748500805987835, "Neutropenia ": 5.2416262542579855, "Neutrophil count decreased ": 10.200712657016911, "Palmar-plantar erythrodysaesthesia syndrome ": 3.613964997254565, "Paronychia ": 352.93183242823807, "Polyneuropathy ": 16.7667016003144, "Pulmonary toxicity ": 12.159814541873336, "Rash ": 3.281277092324803, "Rash papular ": 4.626204344969101, "Rash pustular ": 45.27706100547796, "Rectal cancer ": 33.04762335678139, "Skin disorder ": 32.60552939365841, "Skin exfoliation ": 2.359484520363897, "Skin fissures ": 47.82367735227727, "Skin lesion ": 5.616056866047897, "Skin reaction ": 3.559296880273886, "Skin toxicity ": 206.9874088392349, "Skin ulcer ": 5.445784883195207, "Stomatitis ": 17.432560332732237, "Therapy partial responder ": 48.86753638740368, "Thrombocytopenia ": 3.5222322213200257, "Xerosis ": 82.14570575782956} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1134.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1134.json new file mode 100644 index 00000000000..de5e1e232b4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1134.json @@ -0,0 +1 @@ +{"Abdominal pain ": 4.741973448856593, "Arthritis ": 4.097538891715336, "Colitis ulcerative ": 30.062009106782423, "Condition aggravated ": 3.1888535048955946, "Crohn's disease ": 22.84430573938296, "Diarrhoea haemorrhagic ": 26.865440061831706, "Frequent bowel movements ": 17.89618934955584, "Haematochezia ": 9.751189704630647, "Intestinal obstruction ": 13.852601989038355, "Off label use ": 2.378602407668343, "Pancreatitis ": 3.0795259033172697, "Rectal tenesmus ": 167.032954129367, "Treatment failure ": 5.920606357370708, "Tubulointerstitial nephritis ": 12.044150533428796} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1135.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1135.json new file mode 100644 index 00000000000..f8e0e3f0764 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1135.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 4.133161722136973, "Acute respiratory distress syndrome ": 10.874998640123248, "Acute respiratory failure ": 6.444266261739045, "Alanine aminotransferase increased ": 10.411061807185282, "Aspartate aminotransferase increased ": 6.95137114551639, "Blood bilirubin increased ": 2.126614091533756, "Bradycardia ": 27.1104221545622, "Bronchopulmonary aspergillosis ": 12.41388475154058, "COVID-19 ": 4.331611958135347, "COVID-19 pneumonia ": 79.37823305738294, "COVID-19 treatment ": 1780.4834397195566, "Cholestasis ": 6.920885370136371, "Death ": 7.301323382850774, "Diffuse alveolar damage ": 114.90542522580029, "Disseminated intravascular coagulation ": 6.695303413776047, "Drug ineffective ": 2.254505022029357, "Drug-induced liver injury ": 8.380741867219967, "Electrocardiogram QT prolonged ": 2.251513952628348, "Gamma-glutamyltransferase increased ": 5.193114548116566, "Genotype drug resistance test positive ": 29.40038008298592, "Hepatic cytolysis ": 4.614005283067123, "Hepatic enzyme increased ": 4.216169567130054, "Hepatic function abnormal ": 8.918923321155901, "Hepatitis ": 2.9559867798437365, "Hepatocellular injury ": 13.352466463644827, "Hepatotoxicity ": 5.511694354431929, "Hypertransaminasaemia ": 53.03210328347535, "Hypoxia ": 5.687383023688201, "Liver disorder ": 6.838037003637965, "Liver function test abnormal ": 2.9021044936551323, "Liver function test increased ": 6.350322093652966, "Maternal exposure during pregnancy ": 4.3910939728096015, "Mechanical ventilation ": 39.69780482614727, "Multiple organ dysfunction syndrome ": 7.202359625838215, "Off label use ": 2.014205999875532, "Oxygen saturation decreased ": 8.443477208431764, "Pancreatitis acute ": 3.737774416605651, "Pneumonia ": 2.703510660361577, "Pneumonia aspiration ": 18.59509359871149, "Pneumonia bacterial ": 25.596881324023062, "Pneumothorax ": 6.45504451922386, "Recalled product ": 59.5778111170493, "Recalled product administered ": 83.27717717468008, "Renal impairment ": 10.571195892020745, "Respiratory disorder ": 6.433615956628006, "Respiratory failure ": 12.805043378339024, "SARS-CoV-2 test positive ": 15.97268192033812, "Septic shock ": 3.8146225518168895, "Sinus bradycardia ": 85.14390711368713, "Therapeutic response decreased ": 8.776703326529509, "Transaminases increased ": 33.80608144121106, "Treatment failure ": 4.242988779666023} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1136.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1136.json new file mode 100644 index 00000000000..41a4f1e5fec --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1136.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.66506377757137, "Altered state of consciousness ": 4.04357212866022, "Anaemia ": 3.672016155333727, "Bronchitis ": 3.929137749055732, "Cardiac failure ": 2.960813416272861, "Cardiac failure congestive ": 2.4778059197327957, "Constipation ": 2.5651882661860657, "Deep vein thrombosis ": 2.198939800892246, "Dehydration ": 2.380927971795404, "Disease progression ": 5.665889524991814, "Febrile neutropenia ": 5.169660030664931, "Haemoglobin decreased ": 2.1962973603249503, "Hypotension ": 2.0017096953687905, "Interstitial lung disease ": 2.76094355520009, "Neuropathy peripheral ": 29.672548275760725, "Neutropenia ": 4.662493760235537, "Oedema peripheral ": 2.60668859245986, "Orthostatic hypotension ": 7.054511278530482, "Pancytopenia ": 7.039671369657623, "Peripheral sensory neuropathy ": 29.22554974512547, "Plasma cell myeloma ": 42.29686851612029, "Platelet count decreased ": 5.960080097788925, "Pneumonia ": 3.0151010525220934, "Pneumonitis ": 5.55748686591266, "Sepsis ": 3.580043646147463, "Septic shock ": 4.820167045058219, "Thrombocytopenia ": 6.2444500285199895, "Tumour lysis syndrome ": 22.633976958755504, "White blood cell count decreased ": 2.298869246355656} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1137.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1137.json new file mode 100644 index 00000000000..56ac0e6d22d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1137.json @@ -0,0 +1 @@ +{"Abdominal pain ": 3.4784539042357245, "Acute kidney injury ": 7.196393711189057, "Angioedema ": 5.602820157227052, "Diarrhoea ": 4.1894846799870615, "Hyperkalaemia ": 4.129412199973573, "Inappropriate schedule of product administration ": 2.2003833446325527, "Lactic acidosis ": 83.63659740336495, "Lipase increased ": 39.6792820680849, "Metabolic acidosis ": 14.374027664108525, "Pancreatic carcinoma ": 8.513084692751528, "Pancreatitis ": 23.734504115941363, "Pancreatitis acute ": 39.9984755530353, "Pemphigoid ": 20.90526843295087, "Renal failure ": 3.589475444829251, "Weight decreased ": 2.7928500003767067, "Wrong technique in product usage process ": 3.9069895667692784} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1138.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1138.json new file mode 100644 index 00000000000..be8cf25872d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1138.json @@ -0,0 +1 @@ +{"Adverse event ": 2.1524767072561164, "Arteriovenous fistula operation ": 291.3353824941928, "Blood glucose decreased ": 2.6863316790540908, "Blood magnesium decreased ": 11.610696779373075, "Blood potassium abnormal ": 56.25309808655963, "Blood potassium decreased ": 20.337569614335195, "Blood potassium increased ": 99.879597427072, "Blood pressure abnormal ": 3.57282827245338, "Cardiac disorder ": 3.0578904527014226, "Cardiac failure congestive ": 6.160484277416457, "Cardiac operation ": 23.730704008947303, "Cardiac pacemaker insertion ": 7.452652347562415, "Cataract operation ": 8.733156986795626, "Cellulitis ": 2.204686974173617, "Cerebrovascular accident ": 2.253586628905528, "Constipation ": 11.100229492003235, "Coronavirus infection ": 9.024962822027758, "Death ": 18.584711376729523, "Dehydration ": 3.1049703326345317, "Dialysis ": 180.3347499129436, "End stage renal disease ": 7.336852987913095, "Eye operation ": 25.131552688500403, "Faecaloma ": 19.02855262070299, "Faeces hard ": 26.004480889399872, "Fall ": 3.3885943969551566, "Flatulence ": 7.530204623928852, "Fluid retention ": 4.536391466188369, "Gout ": 3.912958067469365, "Haematochezia ": 2.6906271494039675, "Hip fracture ": 4.809590408597058, "Hospice care ": 109.95741889958036, "Hospitalisation ": 62.73956667455344, "Hypercalcaemia ": 3.483191689112846, "Hyperkalaemia ": 5.958558051814749, "Hypervolaemia ": 14.59895076502313, "Hypomagnesaemia ": 7.97588770792165, "Ill-defined disorder ": 2.848164425155161, "Illness ": 2.835803713512031, "Inappropriate schedule of product administration ": 6.70791792925514, "Infection ": 2.09302967727532, "Intestinal obstruction ": 2.419053203659203, "Leg amputation ": 19.24300274765625, "Limb injury ": 2.5276264457264697, "Localised infection ": 11.274868997110266, "Lower limb fracture ": 5.364909615279473, "Mental status changes ": 2.292959871453379, "Metabolic acidosis ": 4.637132775526004, "Myocardial infarction ": 2.7420414028758637, "Off label use ": 4.022431387005948, "Pericardial effusion ": 2.061419099827796, "Pneumonia ": 4.029757239127397, "Product colour issue ": 27.22284756317718, "Product dose omission in error ": 9.88908215681454, "Product dose omission issue ": 16.37462033626292, "Product physical issue ": 7.1747585753016505, "Product preparation error ": 22.44627072962048, "Product solubility abnormal ": 26.677681737825765, "Product taste abnormal ": 25.202732683878335, "Pulmonary oedema ": 4.81279038444067, "Rehabilitation therapy ": 45.52358652067237, "Renal disorder ": 9.087973656962811, "Renal failure ": 2.843566311214428, "Renal impairment ": 2.8466656304940057, "Renal transplant ": 58.12345243109648, "Spinal operation ": 8.799023127062497, "Stent placement ": 5.932678121856803, "Surgery ": 15.56228087811788, "Thrombosis ": 2.3351573519179567, "Toe amputation ": 22.579026283911684, "Transfusion ": 5.369868749684438, "Treatment noncompliance ": 8.344193946134597, "Unevaluable event ": 3.6204475883416447, "Urinary tract infection ": 4.649251522167996, "Viral infection ": 2.1320334894862145} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1139.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1139.json new file mode 100644 index 00000000000..801397d971c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1139.json @@ -0,0 +1 @@ +{"Abdominal distension ": 4.0675649462136025, "Alanine aminotransferase increased ": 10.911000156161284, "Aspartate aminotransferase increased ": 3.2972010100792177, "Cerebral infarction ": 7.658873699605869, "Drug ineffective ": 6.336854370383594, "Drug resistance ": 6.855741903061904, "Dysphagia ": 8.147846033925518, "Hepatic cancer ": 20.873704873934525, "Hepatic function abnormal ": 3.19438945838244, "Hepatitis B ": 66.57821702822208, "Hepatitis B DNA assay positive ": 1966.8875608376236, "Hepatitis B DNA increased ": 801.0197711433434, "Hepatocellular carcinoma ": 23.079483594531577, "Jaundice ": 4.289553151657469, "Lactic acidosis ": 4.63161942658897, "Liver function test increased ": 10.802338272128758, "Maternal exposure during pregnancy ": 2.955896832124799, "Neoplasm malignant ": 4.206086757849832, "Off label use ": 2.3647412003107924, "Osteoporosis ": 2.444969294416385, "Product dispensing error ": 16.39437735989556, "Renal impairment ": 6.653247428899967, "Suspected counterfeit product ": 111.26280859592256, "Transaminases increased ": 7.901622306157551, "Treatment noncompliance ": 9.15822564032372, "Viral load increased ": 72.46452354431024} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/114.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/114.json new file mode 100644 index 00000000000..f6323917ff4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/114.json @@ -0,0 +1 @@ +{"Abortion induced ": 4.153367745355752, "Acute kidney injury ": 2.023765548907209, "Adrenal insufficiency ": 7.97963607195084, "Alanine aminotransferase increased ": 2.505190556668073, "Alcohol abuse ": 6.645046683104713, "Anxiety ": 5.121372204897111, "Aspartate aminotransferase increased ": 2.363250553784149, "Ataxia ": 3.932043254125021, "Atypical mycobacterial infection ": 32.049539420148186, "Blood HIV RNA increased ": 28.761612174353623, "Blood bilirubin increased ": 10.424721826464426, "Blood corticotrophin decreased ": 54.7351435884485, "Blood creatinine increased ": 2.095571234344709, "Blood lactic acid increased ": 11.725825826076662, "Blood phosphorus decreased ": 10.962271197995966, "Blood triglycerides increased ": 6.371910898749496, "CD4 lymphocytes decreased ": 11.57418142665117, "CSF HIV escape syndrome ": 2394.0921920514274, "Caesarean section ": 16.085530684191454, "Calculus urinary ": 12.828423912730242, "Castleman's disease ": 59.106242291052055, "Cholelithiasis ": 3.728836463302295, "Cholestasis ": 2.3912400738544197, "Conduction disorder ": 21.73677903698688, "Cortisol decreased ": 36.988856913248135, "Cushing's syndrome ": 59.02164351161097, "Cushingoid ": 29.346107220391357, "Depression ": 16.76957930501159, "Depression suicidal ": 440.8795870909281, "Depressive symptom ": 237.3642493336832, "Diplegia ": 7.374381317448041, "Diplopia ": 5.372917610885135, "Drug interaction ": 20.133361695912857, "Drug level increased ": 6.197060041964054, "Drug resistance ": 14.086224655416688, "Ergot poisoning ": 132.506042993111, "Eyelid ptosis ": 24.287355271893244, "Fanconi syndrome ": 11.1244362943146, "Fanconi syndrome acquired ": 7.452611426813426, "Feeling jittery ": 8.568371140194829, "Foetal exposure during delivery ": 37.39790382436052, "Foetal exposure during pregnancy ": 5.007473061321599, "Glomerular filtration rate decreased ": 3.497584496241336, "Goitre ": 7.948387479438012, "Graves' disease ": 7.177943039175762, "Haematuria ": 2.4877349703466427, "Haemolytic anaemia ": 4.045967316400072, "Hepatomegaly ": 2.52835779864938, "Herpes simplex ": 9.305501205112126, "Hiatus hernia ": 3.607914616019385, "Hyperbilirubinaemia ": 38.15087120569685, "Hypercholesterolaemia ": 2.43929409792802, "Hyperlipidaemia ": 11.282554201473989, "Hypertriglyceridaemia ": 6.20822825797017, "Hypophosphataemia ": 5.922991596462227, "Immune reconstitution inflammatory syndrome ": 51.91010536837692, "Jaundice ": 12.434209205190912, "Kaposi's sarcoma ": 52.28693377172978, "Labelled drug-drug interaction medication error ": 2.9753748982531047, "Lipoatrophy ": 46.76954413248669, "Lipodystrophy acquired ": 61.83313937217041, "Lipohypertrophy ": 22.06335317116376, "Live birth ": 6.586866486370775, "Loss of personal independence in daily activities ": 6.757673573466355, "Low birth weight baby ": 4.715409218773686, "Maternal exposure during pregnancy ": 4.277587027962828, "Meningitis cryptococcal ": 24.8479624139308, "Mitochondrial toxicity ": 116.3955291996319, "Mycobacterium avium complex infection ": 18.57641566219981, "Nephrolithiasis ": 7.957820034645501, "Nephropathy toxic ": 6.158190605585218, "No adverse event ": 2.2323945196317108, "Normal newborn ": 14.06872212636886, "Ocular icterus ": 11.090474091391656, "Oesophageal candidiasis ": 10.04628461425767, "Oesophageal varices haemorrhage ": 9.80135768428901, "Ophthalmoplegia ": 36.33223870588911, "Opportunistic infection ": 24.38041814153666, "Oropharyngeal candidiasis ": 26.000716492086333, "Paranoia ": 99.48050623294212, "Parkinsonism ": 2.666821968980529, "Pathogen resistance ": 17.206287741141267, "Pelvic pain ": 2.2885052499429435, "Peripheral sensory neuropathy ": 5.237790466362527, "Petit mal epilepsy ": 4.978780549385239, "Pneumocystis jirovecii pneumonia ": 3.2423914012172053, "Premature baby ": 2.871120816341852, "Premature delivery ": 6.813730009955076, "Premature rupture of membranes ": 32.343802528227194, "Prescribed overdose ": 4.220689305099393, "Product use in unapproved indication ": 3.759087506675887, "Progressive multifocal leukoencephalopathy ": 11.761033010294092, "Proteinuria ": 2.731940268553985, "Psychiatric decompensation ": 864.076421109176, "Psychomotor retardation ": 40.67810696512076, "Psychomotor skills impaired ": 301.9021919157425, "Psychotic disorder ": 41.69863048539939, "Rales ": 4.206955054090167, "Renal aplasia ": 32.29630567175754, "Renal colic ": 6.483783072034165, "Renal dysplasia ": 67.53768970241616, "Renal tubular disorder ": 5.917591469883726, "Renal tubular dysfunction ": 18.067675429419836, "Renal tubular necrosis ": 7.597994325723877, "Sinus bradycardia ": 2.189593043333463, "Suicidal ideation ": 13.932797348303165, "Tearfulness ": 274.57716594713185, "Torsade de pointes ": 4.298159269887615, "Treatment failure ": 3.5705765987411344, "Treatment noncompliance ": 9.786167964201455, "Tubulointerstitial nephritis ": 5.016448674455195, "Type 1 diabetes mellitus ": 3.223741427804724, "Viral load increased ": 24.187752007122715, "Viral mutation identified ": 64.9706700637612, "Virologic failure ": 103.92412176085536} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1140.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1140.json new file mode 100644 index 00000000000..d999ef46631 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1140.json @@ -0,0 +1 @@ +{"Actinic keratosis ": 103.93834272041644, "Acute kidney injury ": 3.710170592924233, "Arthralgia ": 2.4287868704359425, "Disease progression ": 15.302382951721825, "Electrocardiogram QT prolonged ": 10.930756011241996, "General physical health deterioration ": 2.1638242702828627, "Hepatotoxicity ": 10.494100004576406, "Hyperkeratosis ": 100.8274759295399, "Keratoacanthoma ": 997.8325576393898, "Keratosis pilaris ": 695.27951974193, "Malignant neoplasm progression ": 2.600347477976096, "Metastases to central nervous system ": 27.65001307014291, "Panniculitis ": 79.29499705804155, "Photosensitivity reaction ": 36.187932257270695, "Rash ": 3.3507221023393154, "Rash maculo-papular ": 4.550570885456634, "Rash papular ": 10.424398817434218, "Skin papilloma ": 195.36745689367575, "Skin toxicity ": 96.46392986524911, "Squamous cell carcinoma ": 148.64567988873424, "Squamous cell carcinoma of skin ": 116.26438322960816, "Therapeutic response decreased ": 6.2988866555371175, "Toxic epidermal necrolysis ": 8.0105525505254, "Uveitis ": 21.973604597435383} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1141.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1141.json new file mode 100644 index 00000000000..f755d86bdc0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1141.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 45.275267894327605, "Acute myeloid leukaemia recurrent ": 31.57815753876872, "Anaemia ": 2.300698703778378, "Autoimmune haemolytic anaemia ": 33.438318546870654, "Blood lactate dehydrogenase increased ": 5.487730788230329, "Blood phosphorus increased ": 19.549374448162773, "Blood test abnormal ": 9.50939809993904, "C-reactive protein increased ": 2.2423657369786785, "COVID-19 ": 2.160652354270927, "COVID-19 pneumonia ": 10.228899579625168, "Chronic lymphocytic leukaemia ": 193.73324655325067, "Chronic lymphocytic leukaemia recurrent ": 195.74492636581317, "Cytopenia ": 28.77747316386831, "Death ": 2.33199452098539, "Drug intolerance ": 5.303852887732111, "Febrile neutropenia ": 7.490228400116724, "General physical health deterioration ": 3.713192362780255, "Hospitalisation ": 3.730798558980714, "Hypercalcaemia ": 5.942842772370103, "Infection ": 6.002955843660029, "Leukopenia ": 3.5229369564159736, "Lymphocyte count increased ": 29.55071079807676, "Multiple organ dysfunction syndrome ": 4.877874921754071, "Neutropenia ": 17.096786469236427, "Off label use ": 20.462934622158564, "Pancytopenia ": 7.634495276913012, "Pneumonia ": 2.5018019681893926, "Product use complaint ": 49.14598022544505, "Respiratory tract infection ": 4.994230510786925, "Richter's syndrome ": 427.98059946162687, "Sepsis ": 4.401901630177815, "Septic shock ": 6.066469106452171, "Splenomegaly ": 9.042304972113335, "Thrombocytopenia ": 6.670853239012609, "Tumour lysis syndrome ": 151.95913557135515, "Unevaluable event ": 5.588489032890303, "White blood cell count increased ": 4.470997287546172} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1142.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1142.json new file mode 100644 index 00000000000..3bbaff9bd09 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1142.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 88.63350198770678, "Acute myeloid leukaemia recurrent ": 116.81213716430454, "Agranulocytosis ": 3.4474401026453334, "Anaemia ": 3.4644083730131223, "Autoimmune haemolytic anaemia ": 35.89574560852182, "Blood calcium decreased ": 5.576604509235185, "Blood lactate dehydrogenase increased ": 7.461897343470305, "Blood phosphorus increased ": 35.59914642081516, "Blood potassium increased ": 6.749537019165823, "Blood uric acid increased ": 5.924699836168286, "Bone marrow failure ": 5.440158670275344, "Bone marrow transplant ": 54.07719449791175, "COVID-19 ": 2.110093507661982, "Chronic lymphocytic leukaemia ": 180.39557737416865, "Chronic lymphocytic leukaemia recurrent ": 121.38606270607632, "Cytopenia ": 62.149635967532646, "Disease progression ": 3.74327964526569, "Dysphagia ": 2.0152991192318424, "Febrile neutropenia ": 26.213232806241308, "Fungal infection ": 5.483313093345237, "Haematotoxicity ": 30.873930476153586, "Haemoglobin decreased ": 3.189824601126929, "Haemolysis ": 6.913563576108045, "Haemolytic anaemia ": 3.1415786739025995, "Hypercalcaemia ": 4.06566124306363, "Immune thrombocytopenia ": 2.607625791171775, "Infection ": 8.29623509573242, "Intentional product use issue ": 2.4442210024458744, "Laboratory test abnormal ": 7.153499136707326, "Leukocytosis ": 3.435863819164556, "Leukopenia ": 3.189345365182621, "Lymphocyte count decreased ": 5.189973608480049, "Mantle cell lymphoma ": 81.83991858205871, "Minimal residual disease ": 273.2854754181052, "Multiple organ dysfunction syndrome ": 2.474981630352914, "Myelodysplastic syndrome ": 9.761312109831897, "Myelosuppression ": 17.075808294633024, "Neutropenia ": 22.121534859030067, "Neutropenic sepsis ": 14.671156167849382, "Neutrophil count decreased ": 5.673746679770883, "Off label use ": 10.22599285725362, "Pancytopenia ": 7.896441014530584, "Plasma cell myeloma ": 11.670601936418954, "Platelet count decreased ": 4.590857825768172, "Pleural effusion ": 2.65605544225935, "Pneumonia ": 3.495110506882911, "Pneumonia fungal ": 21.67345627342415, "Product use complaint ": 20.586116624249826, "Richter's syndrome ": 582.5897667451836, "Sepsis ": 5.3263170275447465, "Septic shock ": 4.587452767872904, "Splenomegaly ": 9.377468403728365, "Systemic mycosis ": 124.90642388616382, "Thrombocytopenia ": 8.100238912211708, "Transplant ": 41.37399124678456, "Tumour lysis syndrome ": 219.76394475950687, "Unevaluable event ": 7.551283964943294, "White blood cell count decreased ": 3.4359587230461583, "White blood cell count increased ": 3.7827634789895215} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1143.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1143.json new file mode 100644 index 00000000000..1667e783b27 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1143.json @@ -0,0 +1 @@ +{"Condition aggravated ": 40.60543900168347, "Off label use ": 11.465374247700511} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1144.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1144.json new file mode 100644 index 00000000000..0b540347ad0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1144.json @@ -0,0 +1 @@ +{"Abdominal pain ": 4.211797262084774, "Constipation ": 16.511806005450712, "Diarrhoea ": 8.472568939081697} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1145.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1145.json new file mode 100644 index 00000000000..0a774401fa8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1145.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 3.37318621636723, "Actinic keratosis ": 38.725050026833394, "Acute leukaemia ": 6.87834777051642, "Acute lymphocytic leukaemia ": 6.079314770104907, "Acute myeloid leukaemia ": 18.24100091948522, "Acute myeloid leukaemia recurrent ": 5.551240884017208, "Agitation ": 2.5421991362655345, "Agranulocytosis ": 2.820135410799613, "Alanine aminotransferase increased ": 5.240374653879671, "Altered state of consciousness ": 5.169284655202852, "Anuria ": 2.5166156093434524, "Aspartate aminotransferase increased ": 6.447846263701006, "Aspergilloma ": 54.06000265178909, "Aspergillus infection ": 38.75906954946362, "Bacteraemia ": 2.203077559365195, "Bacterial infection ": 2.1349486394030004, "Bacterial sepsis ": 3.953155004341159, "Bilirubin conjugated increased ": 7.218602277848142, "Blindness ": 2.007358988849574, "Blindness transient ": 2.4104147160362044, "Blood albumin decreased ": 4.080946502366965, "Blood alkaline phosphatase increased ": 10.306379197647791, "Blood beta-D-glucan increased ": 43.70566324897491, "Blood bilirubin increased ": 6.415889435040623, "Blood creatine phosphokinase increased ": 2.763092579095522, "Blood disorder ": 6.716272222252268, "Blood lactate dehydrogenase increased ": 2.3278358521066296, "Blood magnesium decreased ": 2.2536547217379588, "Bowen's disease ": 15.418936800221308, "Bronchopulmonary aspergillosis ": 28.842559591859, "Candida infection ": 2.6185534434078788, "Cardiac failure ": 2.39340949510036, "Cell death ": 6.7742683819065554, "Cheilitis ": 13.293593542138376, "Chloropsia ": 240.6367787300532, "Cholecystitis ": 4.997080445856948, "Cholecystitis acute ": 5.6911204908364255, "Cholestasis ": 17.574682987499127, "Chromatopsia ": 151.94192232343244, "Colour blindness ": 88.04781897278984, "Complications of transplant surgery ": 48.99452248144711, "Confusional state ": 2.358931423938808, "Cystitis haemorrhagic ": 2.06393136575977, "Deafness bilateral ": 6.348587119684815, "Death ": 2.669613913128396, "Delirium ": 16.57086471565189, "Delusion ": 3.317644910641018, "Dermatitis bullous ": 3.936563750137501, "Dermatitis exfoliative ": 6.396929270622333, "Dermatitis exfoliative generalised ": 5.70596912895872, "Device related infection ": 2.1858518328362457, "Diabetes insipidus ": 3.328160182644789, "Diplopia ": 4.40832791286407, "Disease progression ": 2.9561710220176187, "Disease recurrence ": 3.626196944954191, "Disorganised speech ": 73.83885576482369, "Disorientation ": 2.828792059725842, "Disseminated intravascular coagulation ": 2.297007224643392, "Drug eruption ": 2.138180879813949, "Drug interaction ": 3.0153699861226984, "Drug level above therapeutic ": 13.726665512693025, "Drug level below therapeutic ": 24.51036620670869, "Drug level decreased ": 14.051209239510868, "Drug level increased ": 21.36679761681834, "Drug-induced liver injury ": 4.810024743867458, "Dyschromatopsia ": 73.01145294112155, "Dysphoria ": 9.36907865211444, "Electrocardiogram QT prolonged ": 4.520858977192903, "Encephalopathy ": 3.658346186714437, "Erythropsia ": 117.60732539112094, "Febrile bone marrow aplasia ": 7.414685828411019, "Fluorosis ": 93.42640505607532, "Fungal infection ": 8.529956703517415, "Gallbladder disorder ": 3.3904163348875427, "Gamma-glutamyltransferase increased ": 13.004802692565416, "Graft versus host disease ": 5.906064883103782, "Haemoptysis ": 4.06263832952699, "Haemorrhagic diathesis ": 2.1958086240305077, "Hallucination ": 39.9247386582293, "Hallucination, auditory ": 21.164207312631717, "Hallucination, visual ": 59.75643232354208, "Hallucinations, mixed ": 8.80196688735411, "Halo vision ": 187.24760436163928, "Hepatic cytolysis ": 8.46995234714188, "Hepatic enzyme abnormal ": 3.046953638345157, "Hepatic enzyme increased ": 4.599830115668609, "Hepatic failure ": 3.494106102942393, "Hepatic function abnormal ": 14.997091955294549, "Hepatitis ": 3.4170283704533717, "Hepatitis cholestatic ": 4.177332069915817, "Hepatitis fulminant ": 5.112324998761247, "Hepatocellular injury ": 7.0048517636798895, "Hepatotoxicity ": 5.125883905380617, "Hip fracture ": 2.136264593125449, "Hyperbilirubinaemia ": 2.196505667397472, "Hypokalaemia ": 2.1022499276429425, "Hypomagnesaemia ": 2.216409683302376, "Illusion ": 9.487251932704591, "Immune system disorder ": 2.1204680461567063, "Immunosuppressant drug level increased ": 17.888887628932846, "Inappropriate antidiuretic hormone secretion ": 5.696799664278896, "Jaundice cholestatic ": 4.736084577014103, "Lentigo ": 48.173506867500194, "Leukaemia ": 30.19362380106578, "Leukaemia recurrent ": 21.148782131931178, "Lip blister ": 5.656052732896853, "Liver disorder ": 7.066124976710237, "Liver function test abnormal ": 11.760859097941418, "Liver function test increased ": 8.88344458378139, "Liver injury ": 5.682750917640966, "Logorrhoea ": 6.288063181292692, "Lung disorder ": 2.878510798951254, "Lung transplant rejection ": 39.83635048862307, "Meningitis ": 2.337675901633092, "Mental disorder ": 8.103742127294886, "Mixed liver injury ": 4.071292260662628, "Mucormycosis ": 16.050312198702812, "Multiple organ dysfunction syndrome ": 2.560230636961792, "Myelodysplastic syndrome ": 4.260659062728707, "Neoplasm malignant ": 2.626276122262664, "Neoplasm recurrence ": 5.898440360400695, "Neurotoxicity ": 2.245860206919485, "Optic neuritis ": 5.216255483140998, "Optic neuropathy ": 4.908754258348037, "Pancytopenia ": 2.463818572158823, "Papilloedema ": 9.290576519719766, "Periostitis ": 30.14666225107935, "Persecutory delusion ": 4.118966244746465, "Photophobia ": 13.445438039419347, "Photopsia ": 14.82579612203931, "Photosensitivity reaction ": 31.180583209106384, "Pneumonia ": 2.8129789133751872, "Pneumonia bacterial ": 6.087437432974514, "Pneumonia fungal ": 39.69545904632764, "Product dispensing error ": 2.652762511189472, "Protein total decreased ": 4.426889385910149, "Prothrombin time prolonged ": 3.4019035480767585, "Pseudomembranous colitis ": 4.923921244898617, "Pseudoporphyria ": 128.6672897321775, "Psychiatric symptom ": 4.058998513201081, "Pulmonary haemorrhage ": 3.072916918495556, "Renal disorder ": 2.286695167797914, "Renal impairment ": 5.00017779111373, "Respiratory failure ": 3.3649479216381346, "Restlessness ": 3.5786289372958136, "Retinal haemorrhage ": 6.022153089526001, "Rhabdomyolysis ": 3.031479370740858, "Sepsis ": 2.1529493453502258, "Sinus arrest ": 3.929971468899817, "Skin cancer ": 7.806541663947764, "Skin exfoliation ": 2.395845571748475, "Sleep talking ": 19.60036207220623, "Speech disorder ": 2.146992894476139, "Squamous cell carcinoma ": 12.31691794009347, "Squamous cell carcinoma of skin ": 34.13045195402731, "Stevens-Johnson syndrome ": 2.270270184655644, "Stupor ": 2.255989659425053, "Sunburn ": 15.33528110313298, "Torsade de pointes ": 6.103977272232234, "Toxic epidermal necrolysis ": 2.7803196286874434, "Transaminases increased ": 5.7695527665362185, "Transplant rejection ": 3.4586118534115737, "Ventricular extrasystoles ": 4.020654006826653, "Ventricular fibrillation ": 3.5179796227732254, "Ventricular tachycardia ": 2.8414237504908613, "Vision blurred ": 6.3972850685998495, "Visual acuity reduced ": 5.0568752964547246, "Visual brightness ": 37.90209187304908, "Visual field defect ": 4.902048195383463, "Visual impairment ": 8.021913558434237, "Vitreous floaters ": 2.7677161556824275, "Xanthopsia ": 271.5953308578652} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1146.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1146.json new file mode 100644 index 00000000000..0d929124a25 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1146.json @@ -0,0 +1 @@ +{"Accident ": 9.273741952947256, "Accident at work ": 26.149745521403563, "Accidental exposure to product by child ": 4.213169256520356, "Acquired immunodeficiency syndrome ": 11.27570503361228, "Actinic keratosis ": 5.148200600517941, "Acute myocardial infarction ": 3.071445946813132, "Alcohol interaction ": 5.777872679256765, "Amnesia ": 2.182108693692677, "Aneurysm ": 6.2984258876672055, "Angina pectoris ": 2.8959427574340846, "Angiopathy ": 5.424495460314242, "Ankle fracture ": 2.8047186156148074, "Anorgasmia ": 26.84877206451416, "Aortic aneurysm ": 3.35385269780366, "Arterial occlusive disease ": 6.504272692991568, "Arthropathy ": 2.790431530259921, "Asthenopia ": 3.332223315647417, "Back disorder ": 16.732121240186682, "Back injury ": 5.270025736972341, "Basal cell carcinoma ": 2.3212879676148157, "Benign prostatic hyperplasia ": 8.661753688545563, "Bipolar disorder ": 2.4014734358127616, "Blindness ": 13.731050790795852, "Blindness transient ": 7.056607911421479, "Blindness unilateral ": 14.988245792219963, "Blood cholesterol increased ": 2.724478952654246, "Blood pressure abnormal ": 3.187241642929831, "Blood pressure decreased ": 2.1380259322970727, "Blood testosterone abnormal ": 40.49493697391148, "Blood testosterone decreased ": 27.847725306035787, "Blood urine present ": 3.7674588622550753, "Body height decreased ": 3.0738442587627364, "Brain injury ": 5.539057401403409, "Cardiac disorder ": 3.807353323229152, "Cardiac valve disease ": 2.673370455057589, "Carotid artery disease ": 12.715402064002356, "Cataract ": 4.892272306849099, "Central serous chorioretinopathy ": 36.12022254020403, "Cerebral infarction ": 2.6578668777137664, "Cerebrovascular accident ": 4.845752750982413, "Cerebrovascular disorder ": 7.518862846846932, "Cervical vertebral fracture ": 8.823489078847313, "Chloropsia ": 193.30419561825585, "Chondropathy ": 9.134824202803769, "Chromatopsia ": 38.11186535611529, "Colon cancer ": 3.565595403451879, "Colour blindness ": 13.773448885603768, "Concussion ": 3.0928681978910766, "Conjunctival haemorrhage ": 2.417908368677417, "Coronary artery disease ": 2.5426195759498254, "Coronary artery occlusion ": 3.917861189597612, "Coronary artery stenosis ": 2.757629495168243, "Counterfeit product administered ": 20.12346273094249, "Craniofacial fracture ": 3.734543129463785, "Cyanopsia ": 706.0198119716691, "Deafness ": 10.85084725184446, "Deafness neurosensory ": 4.574890635439518, "Deafness transitory ": 18.932642715529937, "Deafness unilateral ": 12.43748808646233, "Death ": 2.539503134301037, "Dementia Alzheimer's type ": 3.2188180739151204, "Diabetes mellitus ": 9.954056173480808, "Diabetic neuropathy ": 2.0076102337676547, "Diabetic retinopathy ": 2.106208176336417, "Diplopia ": 2.652691510145827, "Disturbance in sexual arousal ": 22.110168688848745, "Drug effective for unapproved indication ": 5.650401654667255, "Drug ineffective ": 2.676513772145808, "Dyschromatopsia ": 19.35378657567842, "Dysuria ": 5.3868097707135405, "Ejaculation delayed ": 26.15578811039196, "Ejaculation disorder ": 179.48332459765524, "Ejaculation failure ": 44.64907448214492, "Erectile dysfunction ": 14.16841436152582, "Erection increased ": 5881.196160640347, "Exostosis ": 2.030754037177817, "Expired product administered ": 4.4169697621793125, "Exposure via partner ": 32.05030219137888, "Extra dose administered ": 6.469810207809299, "Eye disorder ": 4.273283090443046, "Eye haemorrhage ": 4.327113849497902, "Flushing ": 4.921538864250029, "Fracture of penis ": 18.65750474614494, "Frustration tolerance decreased ": 2.4516875379082688, "Gallbladder disorder ": 2.3174803065703093, "Genital hypoaesthesia ": 43.04346605830896, "Glaucoma ": 6.628713638373988, "HIV infection ": 4.956590106852047, "HIV test positive ": 15.282436861438102, "Haematospermia ": 56.93989320388568, "Haemorrhage urinary tract ": 4.050255366374707, "Hemiplegia ": 2.741192564062448, "Hernia ": 10.39443850190733, "Hypoacusis ": 9.31538317451052, "Incorrect dose administered ": 3.2826734037158976, "Infarction ": 5.120376813198256, "Intentional product misuse ": 8.308365312393084, "Intentional product use issue ": 3.238322798031636, "International normalised ratio abnormal ": 2.836846714200943, "Intervertebral disc degeneration ": 2.516620130317171, "Intervertebral disc disorder ": 4.108976633062696, "Intervertebral disc protrusion ": 5.250956694623164, "Intraocular pressure increased ": 3.578398270193223, "Joint dislocation ": 2.0967742615893536, "Large intestine polyp ": 2.0837684194102715, "Lentigo maligna ": 177.21213866619368, "Libido decreased ": 2.5741502400427145, "Libido increased ": 9.50189564743061, "Limb injury ": 3.9514352262055614, "Low density lipoprotein increased ": 2.413573988820143, "Lower limb fracture ": 5.199416524804963, "Macular degeneration ": 2.66454131234433, "Macular hole ": 12.44629385977021, "Macular oedema ": 9.445230570750857, "Male orgasmic disorder ": 52.14127593129213, "Male reproductive tract disorder ": 33.506478751547284, "Malignant melanoma ": 186.55452091965492, "Malignant melanoma in situ ": 304.06768829500163, "Malignant melanoma stage I ": 74.9636904094196, "Malignant melanoma stage II ": 108.97182328947208, "Malignant melanoma stage III ": 115.61467380398553, "Malignant melanoma stage IV ": 116.42887587058576, "Meniscus injury ": 4.307880722785227, "Metamorphopsia ": 5.967008577651318, "Metastases to lymph nodes ": 3.624636339121254, "Metastatic malignant melanoma ": 59.45174475157529, "Micturition disorder ": 2.5469118237308632, "Multiple sclerosis ": 4.001563035040417, "Muscle rupture ": 3.566568541899536, "Muscle strain ": 2.1026059651859947, "Musculoskeletal disorder ": 9.391475175348328, "Myocardial infarction ": 5.754736676708825, "Nasal congestion ": 4.3726339451933, "Near death experience ": 3.817954786452341, "Neoplasm malignant ": 7.365277405295108, "Nerve compression ": 7.345848160742834, "Nerve injury ": 4.288157946079251, "Ocular hyperaemia ": 2.5504874357382774, "Ocular vascular disorder ": 28.872690648385948, "Oesophageal disorder ": 7.571547072739969, "Optic atrophy ": 19.319876776397145, "Optic ischaemic neuropathy ": 115.47809232654626, "Optic nerve disorder ": 24.46343675201418, "Optic neuritis ": 3.170918457452134, "Optic neuropathy ": 4.502740865463051, "Orgasm abnormal ": 15.048400772538647, "Overdose ": 2.18976453470984, "Painful erection ": 481.4038272174812, "Panic reaction ": 2.983754783082659, "Papilloedema ": 5.251589461528071, "Paralysis ": 2.0464886766952586, "Paraplegia ": 4.369812844927618, "Parkinson's disease ": 4.699312148714355, "Penile curvature ": 92.49527136490808, "Penile discharge ": 59.62887672071078, "Penile erythema ": 37.17598490690295, "Penile haemorrhage ": 173.79974977648993, "Penile pain ": 423.2955968071438, "Penile swelling ": 74.23997461824624, "Penile vascular disorder ": 260.1887563605293, "Penis disorder ": 207.54539720643365, "Penis injury ": 61.48212710937026, "Peyronie's disease ": 62.175907366819686, "Phimosis ": 12.475380514967512, "Photopsia ": 6.895560408642696, "Pre-existing condition improved ": 16.21813189710212, "Premature ejaculation ": 53.27596748161916, "Prescription drug used without a prescription ": 30.780490277612422, "Priapism ": 134.18168756080345, "Product counterfeit ": 11.3709334368447, "Product dispensing error ": 3.609722227177732, "Product use in unapproved indication ": 2.501008636836417, "Prostate cancer ": 31.883337595859853, "Prostate cancer recurrent ": 21.43258406191056, "Prostatic disorder ": 67.30083479918393, "Prostatic specific antigen increased ": 2.881588671329942, "Prostatomegaly ": 24.74928990905141, "Pruritus genital ": 2.9465436143331285, "Pulmonary hypertension ": 4.155967594779621, "Retinal artery occlusion ": 10.442709032943352, "Retinal artery thrombosis ": 19.101362640800307, "Retinal degeneration ": 15.485430529342086, "Retinal detachment ": 6.72645592197961, "Retinal disorder ": 5.300067416047055, "Retinal haemorrhage ": 8.816283129497826, "Retinal tear ": 12.81989975830042, "Retinal vascular disorder ": 28.04830552645352, "Retinal vascular occlusion ": 9.724317708831189, "Retinal vein occlusion ": 10.096454587330792, "Retinal vein thrombosis ": 11.930644124753902, "Retinitis pigmentosa ": 70.52044323766061, "Road traffic accident ": 9.19918756923096, "Rotator cuff syndrome ": 3.1146242617501745, "Semen volume increased ": 828.1244651341824, "Sexual abuse ": 73.16288561020968, "Sexual dysfunction ": 2.252570829932949, "Sinus congestion ": 2.6223459312784687, "Skin cancer ": 3.5691967828631066, "Skin discolouration ": 2.9061809066167443, "Sleep apnoea syndrome ": 2.697323635516661, "Spinal disorder ": 7.662366685806326, "Spinal fracture ": 4.435105508680346, "Spontaneous penile erection ": 112.22790155085262, "Squamous cell carcinoma ": 2.186302000294299, "Stress ": 2.360335735435324, "Sudden cardiac death ": 2.0580218466295013, "Sudden death ": 5.247155493449808, "Sudden hearing loss ": 10.130752094237904, "Superficial spreading melanoma stage unspecified ": 136.80159954403308, "Suspected counterfeit product ": 39.69444840473262, "Testicular disorder ": 66.94492655886829, "Testicular pain ": 7.936793095010385, "Testicular swelling ": 25.60408404796653, "Therapeutic product effect decreased ": 2.099528820459497, "Therapeutic product effect delayed ": 17.983703138134878, "Therapeutic product effect incomplete ": 3.866545059249072, "Therapeutic product effect prolonged ": 23.9103810965175, "Therapeutic response unexpected ": 4.223510357457662, "Throat cancer ": 13.529051263072487, "Transient global amnesia ": 24.61715033783391, "Transient ischaemic attack ": 2.4243683607311506, "Tunnel vision ": 6.230160285141155, "Type 2 diabetes mellitus ": 3.30274636041995, "Urinary retention ": 2.471502722925835, "Vascular rupture ": 10.729412250067451, "Vein disorder ": 7.525102830157734, "Ventricular fibrillation ": 3.739327185404726, "Vision blurred ": 4.441704833258853, "Visual acuity reduced ": 5.984875990811678, "Visual brightness ": 84.09992242207515, "Visual field defect ": 18.87157777445864, "Visual impairment ": 4.79238179223219, "Vitreous detachment ": 9.086964720024444, "Vitreous floaters ": 4.407535120403818, "Vitreous haemorrhage ": 3.433747060083016, "Weight fluctuation ": 2.527710865504817} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1147.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1147.json new file mode 100644 index 00000000000..fc22044c776 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1147.json @@ -0,0 +1 @@ +{"Abdominal distension ": 4.147193277436177, "Abdominal pain ": 2.966259794804712, "Abdominal pain upper ": 2.87260161728877, "Abortion induced ": 2.269932421426158, "Acute kidney injury ": 2.6229327439467927, "Adenocarcinoma pancreas ": 46.48740408674061, "Amylase increased ": 16.046099336631087, "Appendicitis ": 2.31312756745515, "Autoimmune hepatitis ": 2.5180574282031314, "Benign neoplasm of thyroid gland ": 39.72980162554838, "Blood glucose abnormal ": 4.417699145759358, "Blood glucose decreased ": 6.525767397011831, "Blood glucose fluctuation ": 3.3877568447712973, "Blood glucose increased ": 8.438156748718939, "Blood potassium decreased ": 2.0288596605025586, "Blood triglycerides increased ": 2.7627493888279755, "Cataract ": 3.3927650197464114, "Cataract operation ": 6.768444630570269, "Cholangiocarcinoma ": 23.73977713867856, "Cholecystectomy ": 6.528368245776929, "Cholecystitis ": 8.163008772306082, "Cholecystitis acute ": 13.510955063997743, "Cholelithiasis ": 17.57159315246899, "Colitis ischaemic ": 3.451765258297684, "Colon cancer ": 2.600259794778375, "Constipation ": 3.4462840761171587, "Coronary artery occlusion ": 2.3532820597172592, "Decreased appetite ": 2.810757746304368, "Dehydration ": 6.978558000224387, "Device failure ": 4.662898401022784, "Device issue ": 3.4452949900252854, "Device leakage ": 3.250891963986737, "Device malfunction ": 4.114687301311931, "Diabetes mellitus inadequate control ": 11.58427270641132, "Diabetic ketoacidosis ": 4.578475012706931, "Diabetic neuropathy ": 3.0294064947212456, "Diabetic retinopathy ": 7.660216272847081, "Diarrhoea ": 3.218254485630264, "Disability ": 5.528267150056457, "Drug dose titration not performed ": 85.72400872359394, "Drug titration error ": 50.32299888265407, "Dyspepsia ": 3.238683133725344, "Eructation ": 19.834821393941635, "Flatulence ": 5.205338735664096, "Follicular thyroid cancer ": 78.31832896643316, "Gallbladder disorder ": 7.830432206339846, "Gastritis ": 3.0652473524924875, "Gastroenteritis ": 3.2234851484166223, "Gastroenteritis viral ": 3.322073186645235, "Gastrointestinal disorder ": 2.3899893909189664, "Gastrointestinal pain ": 2.1806319908026577, "Gastrooesophageal reflux disease ": 2.349150432909007, "Glycosylated haemoglobin abnormal ": 22.177711570348077, "Glycosylated haemoglobin decreased ": 18.19844092307215, "Glycosylated haemoglobin increased ": 11.673120008489402, "Goitre ": 8.501316929733099, "Hepatic cirrhosis ": 2.083593490886563, "Hepatic steatosis ": 3.8951975724747423, "Hiccups ": 4.322369355181453, "Hunger ": 4.773325016414194, "Hyperlipasaemia ": 30.11313092837085, "Hypoglycaemia ": 2.625835609032304, "Hypoglycaemic unconsciousness ": 4.285409504948167, "Ileus ": 2.059842546515042, "Ileus paralytic ": 2.955113419600842, "Impaired gastric emptying ": 20.08028268308285, "Incorrect dose administered by device ": 3.2255219113000813, "Increased appetite ": 2.8510786813976363, "Injection site bruising ": 5.8323701484702735, "Injection site haemorrhage ": 3.296505392407152, "Injection site hypersensitivity ": 9.236246778390662, "Injection site mass ": 3.465013803787788, "Injection site pruritus ": 3.7417049951661103, "Injection site rash ": 12.193248639472198, "Injection site urticaria ": 11.09685250007087, "Intentional dose omission ": 3.1675452057313227, "Intestinal obstruction ": 3.960610521782335, "Knee arthroplasty ": 2.0913548134192794, "Lipase increased ": 24.9459175265347, "Liquid product physical issue ": 4.15020206228933, "Medullary thyroid cancer ": 180.5402773475419, "Metastases to liver ": 2.166453664493657, "Nausea ": 2.8462924962131986, "Neoplasm malignant ": 2.016679449408947, "Nephrolithiasis ": 3.028214169668568, "Obstructive pancreatitis ": 50.02272033820936, "Oedematous pancreatitis ": 28.364171785632944, "Pancreatic carcinoma ": 40.69340676233741, "Pancreatic carcinoma metastatic ": 55.47004813841591, "Pancreatic carcinoma stage IV ": 91.22781600419644, "Pancreatic cyst ": 13.266886028079169, "Pancreatic disorder ": 14.422045817461632, "Pancreatic enzymes increased ": 11.323564113713998, "Pancreatic mass ": 35.71405912352257, "Pancreatic neoplasm ": 51.11664283703716, "Pancreatic pseudocyst ": 25.740166285726552, "Pancreatitis ": 72.59033108836931, "Pancreatitis acute ": 48.316839087891495, "Pancreatitis chronic ": 21.43339116978135, "Pancreatitis necrotising ": 20.419665985565064, "Papillary thyroid cancer ": 79.29530607505393, "Product colour issue ": 6.474242149881435, "Product quality issue ": 3.073033449615231, "Product storage error ": 2.303510269134493, "Retching ": 2.2573875374910592, "Small intestinal obstruction ": 2.7853069617028905, "Surgery ": 2.311258768995714, "Thyroid cancer ": 15.583935307161669, "Thyroid mass ": 26.639622219158987, "Thyroid neoplasm ": 40.03917374379909, "Vomiting ": 4.004113255286001, "Weight decreased ": 4.980125964083531, "Weight loss poor ": 24.623886041282034} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1148.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1148.json new file mode 100644 index 00000000000..5c6e851e329 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1148.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.182743330766667, "Anaemia ": 10.758613656378882, "Dehydration ": 6.42501695655817, "Haemoglobin decreased ": 8.251055182924466} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1149.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1149.json new file mode 100644 index 00000000000..0f6f9afcec5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1149.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.707435678999812, "Acute myeloid leukaemia ": 84.36671642793335, "Febrile neutropenia ": 22.154718997422755, "Myelosuppression ": 6.565870778276999, "Neutropenia ": 4.324572016306301, "Neutrophil count decreased ": 7.1630388276647485, "Platelet count decreased ": 9.124480373529623, "Pneumonia ": 2.8455797216098664, "Sepsis ": 5.70181607779533, "Subdural haematoma ": 28.560072759698897, "Thrombocytopenia ": 2.1757275131830016, "Tumour lysis syndrome ": 90.17712433636484, "White blood cell count decreased ": 3.5284308059266656} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/115.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/115.json new file mode 100644 index 00000000000..df1a571c137 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/115.json @@ -0,0 +1 @@ +{"Abdominal pain ": 3.42886689881974, "Anaemia ": 4.566416776386276, "Ankylosing spondylitis ": 32.795236475489894, "Balance disorder ": 2.3809068100988, "Candida infection ": 10.800806483576087, "Colitis ": 7.358622293728293, "Constipation ": 8.10373240605348, "Cytokine release syndrome ": 6.166153471434932, "Cytomegalovirus infection ": 19.074988087482023, "Dehydration ": 3.505046874493984, "Diarrhoea ": 2.467650857473803, "Disease progression ": 15.056807582566115, "Dysphagia ": 2.383374202137721, "Ear pain ": 4.1131135400732886, "Febrile neutropenia ": 2.8218283362710674, "Haemoglobin decreased ": 2.1003973803413603, "Hepatitis ": 6.289550208532255, "Hydronephrosis ": 26.331409446449765, "Hyperthyroidism ": 8.26289013904903, "Hypokalaemia ": 5.313904244089062, "Hypomagnesaemia ": 54.74344519866453, "Hyponatraemia ": 3.300203346687173, "Hypothyroidism ": 5.28004628499475, "Infusion related reaction ": 5.885192582113821, "Intentional product use issue ": 3.18133767053616, "Jaundice ": 2.472686665377009, "Lymphoma transformation ": 1596.3535557185337, "Malignant neoplasm progression ": 4.695144332190645, "Metastases to liver ": 6.005048548619468, "Metastases to lung ": 10.152256653265084, "Mouth ulceration ": 8.224467725938316, "Mucosal inflammation ": 19.538782463051007, "Neoplasm ": 20.45436345506358, "Nervous system disorder ": 9.8152565456443, "Neuropathy peripheral ": 3.1606714961359264, "Neutropenic sepsis ": 42.51883667150901, "Neutrophil count decreased ": 7.131476575282872, "Off label use ": 2.0011936171566296, "Pneumonitis ": 11.961241494089322, "Product use in unapproved indication ": 2.371840889895564, "Productive cough ": 4.641529942280488, "Sepsis ": 3.70301890065032, "Skin candida ": 425.0378573062477, "Skin toxicity ": 34.12375280384661, "Stomatitis ": 2.092740406991724, "Upper respiratory tract infection ": 4.91300134148857, "White blood cell count decreased ": 2.5637776412844078} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1150.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1150.json new file mode 100644 index 00000000000..c56c256a3bd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1150.json @@ -0,0 +1 @@ +{"Drug interaction ": 12.28502374971411, "Hyperkalaemia ": 37.21698331899839} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1151.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1151.json new file mode 100644 index 00000000000..e7cfb0a2e10 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1151.json @@ -0,0 +1 @@ +{"Condition aggravated ": 2.5670856482066577, "Drug ineffective ": 3.154283395995115, "Drug withdrawal syndrome neonatal ": 41.80210790722083, "Encephalopathy ": 20.375410411569156, "Epilepsy ": 5.661081061762026, "Exposure during pregnancy ": 2.4990749426151813, "Foetal exposure during pregnancy ": 4.969120428596721, "Infantile spasms ": 355.6710013672589, "Magnetic resonance imaging abnormal ": 215.38064940058064, "Magnetic resonance imaging head abnormal ": 1295.492678923104, "Maternal exposure during pregnancy ": 3.5638714753386647, "Neonatal behavioural syndrome ": 2147.1499701144967, "Optic atrophy ": 206.5678709662796, "Optical coherence tomography abnormal ": 3883.8639835737167, "Psychotic disorder ": 8.19166123294794, "Retinal disorder ": 495.6011520809989, "Retinal toxicity ": 363.0742873900012, "Retinogram abnormal ": 2065.285641059615, "Seizure ": 14.97290237231165, "Status epilepticus ": 22.59161791463593, "Therapeutic product effect incomplete ": 2.921944205234387, "Toxicity to various agents ": 6.297140798308555, "Visual acuity reduced ": 16.361061148031908, "Visual field defect ": 386.7798912250898} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1152.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1152.json new file mode 100644 index 00000000000..251f92e7cf3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1152.json @@ -0,0 +1 @@ +{"Blister ": 8.470375359176595, "Blood creatine phosphokinase increased ": 5.777031937086752, "Blood glucose increased ": 2.83613018404912, "Blood phosphorus increased ": 65.6311665791848, "Bradycardia ": 2.7250977614074783, "Coma ": 5.755527578245456, "Diabetes mellitus inadequate control ": 17.407003863466525, "Drug interaction ": 3.542857902475625, "Glycosylated haemoglobin increased ": 9.115781457933426, "Hepatic function abnormal ": 2.248476036411119, "Hepatitis ": 7.64271220380885, "Hyperglycaemia ": 3.876675118939951, "Hyperkalaemia ": 3.9967030013145792, "Hypocalcaemia ": 20.615279119395343, "Hypoglycaemia ": 11.471835693692643, "Hypoglycaemic coma ": 17.5055450558708, "Hypomagnesaemia ": 29.407481795694157, "Hypoparathyroidism ": 382.4531151659439, "Intentional overdose ": 4.282044848885023, "Jaundice ": 4.110742156128029, "Lactic acidosis ": 11.333772610235249, "Metabolic acidosis ": 8.964177702938553, "Pancreatitis acute ": 15.667470033671016, "Pemphigoid ": 350.16633668975106, "Renal impairment ": 5.058941146568038, "Rhabdomyolysis ": 3.732917095042711, "Syncope ": 4.616278790280124, "Ventricular tachycardia ": 26.00611653007701} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1153.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1153.json new file mode 100644 index 00000000000..51b78694c50 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1153.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 4.281961212219553, "Abortion induced ": 4.636131950338319, "Accidental exposure to product ": 4.240859210788143, "Affective disorder ": 3.776545546033588, "Aggression ": 7.013525434769154, "Agitation ": 3.1788310313852857, "Agranulocytosis ": 2.426673470568219, "Altered state of consciousness ": 2.4306724795353998, "Amnesia ": 4.040217485068628, "Anger ": 3.642161823997201, "Anticonvulsant drug level increased ": 12.554149828038058, "Apathy ": 2.0269299023052576, "Aphasia ": 2.75008718179607, "Ataxia ": 6.340599246525355, "Atrial fibrillation ": 2.00903114727133, "Atrial flutter ": 3.4506883187713835, "Atrioventricular block ": 17.732712575178837, "Atrioventricular block complete ": 16.681126822021746, "Atrioventricular block first degree ": 9.6620518278023, "Atrioventricular block second degree ": 23.20596074028522, "Aura ": 26.866118462741696, "Balance disorder ": 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"Encephalopathy ": 3.95509993170344, "Epilepsy ": 25.420998187503887, "Fall ": 2.8620276779880887, "Feeling drunk ": 3.626686513189072, "Focal dyscognitive seizures ": 32.42546357454082, "Gait disturbance ": 2.31077461611732, "Generalised tonic-clonic seizure ": 18.054479368923, "Hallucination ": 2.0653796496900183, "Hallucination, auditory ": 3.284362503392343, "Hallucination, visual ": 2.800729348188799, "Head injury ": 5.443299115673567, "Hospitalisation ": 3.5551924961600005, "Inability to afford medication ": 15.869477421325698, "Inappropriate schedule of product administration ": 3.0583068445172046, "Intentional product misuse ": 2.171438806846552, "Irritability ": 4.579458755173473, "Maternal exposure before pregnancy ": 23.43509053558697, "Maternal exposure during breast feeding ": 3.756021888934713, "Maternal exposure during pregnancy ": 6.051934033251827, "Memory impairment ": 3.4185507630444425, "Mental disorder ": 2.702442678953964, "Mood altered ": 2.6923124794718207, "Mood swings ": 2.494658604364797, "Multiple-drug resistance ": 6.261785591153815, "Myoclonic epilepsy ": 17.582460393016248, "Myoclonus ": 6.765741841462612, "No adverse event ": 2.1066351862654185, "Nystagmus ": 7.102562501107253, "Off label use ": 4.113300378642836, "Overdose ": 4.611095916495148, "Paranoia ": 2.999011153345502, "Partial seizures ": 22.32943163219125, "Partial seizures with secondary generalisation ": 47.58366789819265, "Petit mal epilepsy ": 26.92714130644329, "Pneumonia aspiration ": 5.463928137418055, "Pregnancy ": 2.668376815105756, "Prescribed underdose ": 2.582923215234883, "Product administration error ": 2.1304216253860155, "Product availability issue ": 6.260828099343911, "Psychotic disorder ": 5.068324218192024, "Screaming ": 3.666126751812902, "Sedation ": 2.979379989058401, "Seizure ": 16.704293888080826, "Seizure cluster ": 40.73193805559014, "Sinus arrest ": 11.929946652569347, "Sinus bradycardia ": 5.197284563639514, "Sinus node dysfunction ": 31.477807612871057, "Sluggishness ": 4.189586734818063, "Somnolence ": 4.072442606486097, "Staring ": 8.219892698013998, "Status epilepticus ": 22.31444620132796, "Stevens-Johnson syndrome ": 2.080520459582734, "Sudden unexplained death in epilepsy ": 95.01405375128653, "Suicidal ideation ": 5.340918290497152, "Suicide attempt ": 3.241727123380294, "Therapeutic product ineffective ": 11.11257082977158, "Therapeutic response unexpected ": 2.2983915736907807, "Therapy interrupted ": 8.308937075724902, "Treatment noncompliance ": 3.520220791017492, "Underdose ": 3.126602007759616, "Ventricular fibrillation ": 2.128275978840651, "Vertigo ": 3.5528358129278304, "Vision blurred ": 2.6483250451990625, "Wrong technique in product usage process ": 2.2456317062} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1154.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1154.json new file mode 100644 index 00000000000..fc322bf3518 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1154.json @@ -0,0 +1 @@ +{"Foetal exposure during pregnancy ": 20.004843570465844} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1155.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1155.json new file mode 100644 index 00000000000..46829b444d0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1155.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 18.76939921792588, "Alanine aminotransferase increased ": 4.914150141272623, "Ascites ": 6.555868611360491, "Aspartate aminotransferase increased ": 3.878041316451128, "Blood alkaline phosphatase increased ": 3.955033721033424, "Blood bilirubin increased ": 5.303939711692982, "Blood creatine phosphokinase increased ": 2.801894823126513, "Blood lactate dehydrogenase increased ": 4.683304377800899, "Cholestasis ": 4.318429006362471, "Conjunctivitis ": 7.450527180532714, "Drug eruption ": 2.441888774818128, "Drug reaction with eosinophilia and systemic symptoms ": 4.317680861849677, "Drug resistance ": 6.119840934414189, "Eosinophilia ": 7.086952592395356, "Erythema multiforme ": 3.425540464276031, "Foetal exposure during pregnancy ": 2.4677831812204265, "Gamma-glutamyltransferase increased ": 8.272662946028708, "Hepatic cirrhosis ": 6.312214284861156, "Hepatic cytolysis ": 5.169643190242111, "Hepatic enzyme increased ": 5.354667022882833, "Hepatic failure ": 16.531134540057057, "Hepatic necrosis ": 25.42466373157117, "Hepatitis ": 28.122670851311444, "Hepatitis acute ": 9.148280883816811, "Hepatitis cholestatic ": 21.38444524199395, "Hepatitis fulminant ": 33.2294897419774, "Hepatitis toxic ": 18.58154531849236, "Hepatotoxicity ": 17.558247300172678, "Hypersensitivity ": 2.727478208548566, "Jaundice ": 14.291736992269046, "Lactic acidosis ": 3.731626853255287, "Liver function test abnormal ": 16.01907328745246, "Liver function test increased ": 6.119552773167825, "Mouth ulceration ": 5.449754130300336, "Mucosal inflammation ": 3.400807573853644, "Pancreatitis ": 3.915676478387241, "Pregnancy ": 17.038471055472254, "Premature baby ": 2.8678991685492417, "Product residue present ": 44.68375910299325, "Pulmonary oedema ": 2.8204866214109217, "Rash ": 4.934436553749154, "Rash erythematous ": 2.342529101630762, "Rash macular ": 2.817503696732849, "Rash maculo-papular ": 15.258290759774964, "Rash papular ": 3.7476867776574343, "Stevens-Johnson syndrome ": 69.85535057626883, "Toxic epidermal necrolysis ": 21.714389466617284, "Transaminases increased ": 5.905704280481863} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1156.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1156.json new file mode 100644 index 00000000000..5112cb0d506 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1156.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 6.391687157265298, "Alanine aminotransferase increased ": 2.1396171183624624, "Amylase increased ": 4.285906087678335, "Anhedonia ": 20.621645383123106, "Ankle fracture ": 8.570846317041044, "Anxiety ": 5.714051501038864, "Azotaemia ": 6.17060581069334, "Blood creatinine abnormal ": 10.09269997643117, "Blood creatinine increased ": 10.32024122744794, "Blood lactic acid increased ": 3.920168711991569, "Blood phosphorus decreased ": 57.434493122318216, "Blood urea increased ": 2.15818720768301, "Bone demineralisation ": 19.189644575770068, "Bone density abnormal ": 8.572696541278924, "Bone density decreased ": 17.818182053264678, "Bone disorder ": 8.314844943384319, "Bone loss ": 15.37925182188718, "Bone pain ": 2.7399374512305257, "CD4 lymphocytes decreased ": 10.5701402684543, "Chronic kidney disease ": 21.521353315105976, "Creatinine renal clearance decreased ": 12.033136367273626, "Decreased activity ": 6.932719736180123, "Drug resistance ": 4.757009853657179, "Economic problem ": 21.96826897371798, "Emotional distress ": 18.20795610370266, "End stage renal disease ": 34.05433917524757, "Fanconi syndrome ": 114.53323562815063, "Fanconi syndrome acquired ": 159.86361809160002, "Femur fracture ": 5.714946019178719, "Foetal death ": 2.3081138750572574, "Foot fracture ": 8.63491394805124, "Fracture ": 11.318158613347029, "Genotype drug resistance test positive ": 18.85327797861016, "Glomerular filtration rate abnormal ": 8.336870075297226, "Glomerular filtration rate decreased ": 7.780712543780693, "Glycosuria ": 46.00087635976696, "Hepatic cancer ": 2.784639777042697, "Hepatic cirrhosis ": 4.001487236745732, "Hepatic failure ": 2.6300231830330025, "Hepatitis B ": 8.142364790830603, "Hepatitis B DNA assay positive ": 254.68624259722085, "Hepatitis B DNA increased ": 150.2480570451599, "Hepatitis B reactivation ": 14.49678923427908, "Hepatocellular carcinoma ": 2.336098690931376, "Hip fracture ": 5.453202905620159, "Hypocalcaemia ": 2.323657612204268, "Hypophosphataemia ": 70.21664773013512, "Hypophosphataemic osteomalacia ": 118.74644814920156, "Immune reconstitution inflammatory syndrome ": 10.533889057586588, "Intervertebral disc degeneration ": 3.236502444989977, "Lactic acidosis ": 5.014528573869841, "Lipase increased ": 3.8011608575206366, "Loss of personal independence in daily activities ": 2.139403117010488, "Lower limb fracture ": 3.7160225128186983, "Metabolic acidosis ": 3.2378047216976333, "Mitochondrial cytopathy ": 34.07459120981709, "Multiple fractures ": 15.613076504346932, "Nephrogenic diabetes insipidus ": 21.26200462109204, "Nephrolithiasis ": 4.13942258032391, "Nephropathy ": 12.039688814163268, "Nephropathy toxic ": 16.632416206986555, "Nephrotic syndrome ": 3.0242179030742102, "Osteoarthritis ": 2.467252235641249, "Osteomalacia ": 68.067425460411, "Osteonecrosis ": 15.360986277732517, "Osteopenia ": 22.847655999828397, "Osteoporosis ": 22.156577081776984, "Pain ": 2.7221747215539653, "Pathological fracture ": 17.89257424991074, "Polydipsia ": 4.57582520644142, "Polyuria ": 3.669147609982113, "Pregnancy ": 4.715708925021231, "Protein total abnormal ": 15.633383854024098, "Proteinuria ": 13.078849431429168, "Quality of life decreased ": 8.559122373653844, "Renal cyst ": 3.4733137808356984, "Renal disorder ": 2.888561970177501, "Renal failure ": 15.05628439390915, "Renal impairment ": 6.310866433041668, "Renal injury ": 16.73859373631145, "Renal transplant ": 11.51444411457478, "Renal tubular acidosis ": 48.93393444774176, "Renal tubular disorder ": 58.145386047958354, "Renal tubular dysfunction ": 178.77414151084986, "Renal tubular necrosis ": 23.450904354446305, "Rib fracture ": 7.506233451525775, "Skeletal injury ": 17.918695881925714, "Spinal compression fracture ": 6.488513385059476, "Spinal fracture ": 3.3640297252950155, "Spinal osteoarthritis ": 4.147915273253359, "Tibia fracture ": 6.192673703728704, "Tooth fracture ": 8.76327400373845, "Tooth loss ": 12.845982061748348, "Treatment noncompliance ": 2.872559235244783, "Tubulointerstitial nephritis ": 6.433778344184137, "Upper limb fracture ": 2.5726813399254023, "Viral load increased ": 62.40505438352553, "Virologic failure ": 8.64454321459482, "Vitamin D deficiency ": 5.256331873717271, "Wrist fracture ": 8.21730543076955} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1157.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1157.json new file mode 100644 index 00000000000..3e502980475 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1157.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 9.884150363536811, "Blood creatinine increased ": 13.879377033623626, "Drug ineffective ": 4.015238489153802, "Drug ineffective for unapproved indication ": 517.485225236522, "Neutropenia ": 5.456324683902517, "Off label use ": 8.073773040592714, "Renal failure ": 4.997215000637539} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1158.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1158.json new file mode 100644 index 00000000000..c46beaff010 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1158.json @@ -0,0 +1 @@ +{"Actinic keratosis ": 83.87006766051883, "Acute hepatic failure ": 2.5856632098605936, "Acute respiratory distress syndrome ": 3.789822796196181, "Adrenal insufficiency ": 2.0674348526239985, "Agitation ": 2.004671025241877, "Alanine aminotransferase increased ": 3.2081831815878634, "Altered state of consciousness ": 2.107890333258095, "Aspartate aminotransferase increased ": 2.587810809898663, "Aspergillus infection ": 57.90992094083037, "Blood alkaline phosphatase increased ": 7.136350447736459, "Blood bilirubin increased ": 2.3244721819495124, "Brain abscess ": 24.318992157061302, "Bronchopulmonary aspergillosis ": 56.17052401359245, "Candida infection ": 9.04924073335292, "Chloropsia ": 127.34994018849072, "Cholestasis ": 9.493769963397629, "Chromatopsia ": 31.27365558416451, "Condition aggravated ": 2.8745137952545097, "Corneal perforation ": 45.04785603545755, "Delirium ": 11.0079677980353, "Dermatitis bullous ": 3.087547490244901, "Dermatitis exfoliative ": 6.540864814234395, "Disease progression ": 3.05463665182331, "Disorganised speech ": 64.52847963130108, "Drug ineffective ": 4.267802979835388, "Drug ineffective for unapproved indication ": 12.449654114990109, "Drug interaction ": 8.643786093496121, "Drug level above therapeutic ": 30.833456662155744, "Drug level below therapeutic ": 104.16445050301728, "Drug level decreased ": 26.564999521990018, "Drug level increased ": 19.49937869865424, "Drug resistance ": 16.994754019021116, "Drug-induced liver injury ": 16.48798107462812, "Dyschromatopsia ": 31.31668213202654, "Dysphoria ": 3.042502860717484, "Electrocardiogram QT prolonged ": 7.561895174704058, "Electrolyte imbalance ": 3.933001171890683, "Encephalopathy ": 3.177670781034009, "Endophthalmitis ": 3.649767260934433, "Eye disorder ": 3.290277163194757, "Fluoride increased ": 921.6795302682484, "Fluorosis ": 1698.8237236018088, "Fungaemia ": 17.673646397854935, "Fungal infection ": 10.191197263319138, "Fusarium infection ": 70.60356992255576, "Gamma-glutamyltransferase increased ": 4.5742565337314405, "Haemoptysis ": 3.313785930625285, "Hallucination ": 22.376448887865354, "Hallucination, auditory ": 12.79315998657443, "Hallucination, visual ": 44.81446573287334, "Hallucinations, mixed ": 14.197228302801186, "Halo vision ": 56.02069897689224, "Hepatic cytolysis ": 5.309468917463771, "Hepatic enzyme increased ": 5.125327474188579, "Hepatic failure ": 2.309191565203176, "Hepatic function abnormal ": 10.931019075800709, "Hepatitis ": 2.4983580605679574, "Hepatitis cholestatic ": 4.952749714864956, "Hepatocellular injury ": 3.2721592095315155, "Hepatotoxicity ": 24.86453081033385, "Hypercalcaemia ": 3.7060830466172767, "Hypertransaminasaemia ": 6.225721462704013, "Hypertrophic osteoarthropathy ": 473.5437946723953, "Hypokalaemia ": 2.495424746309905, "Immunosuppressant drug level increased ": 24.32719721298393, "Initial insomnia ": 5.681869399632131, "Keratitis fungal ": 197.4420336351838, "Liver function test abnormal ": 4.9609106261429785, "Liver function test increased ": 3.532889541110577, "Liver injury ": 14.16604469093819, "Mania ": 2.045216658957756, "Mental disorder ": 8.13225930813876, "Mucormycosis ": 77.5129449144517, "Multiple organ dysfunction syndrome ": 4.690752964401965, "Multiple-drug resistance ": 4.717739569623929, "Musculoskeletal pain ": 2.3127547665720374, "Nephropathy toxic ": 3.982611378022996, "Nervous system disorder ": 5.956735772289727, "Neurotoxicity ": 12.809669691928049, "Off label use ": 2.7950745958642647, "Pathogen resistance ": 20.880268940562104, "Periostitis ": 2483.749219642236, "Photodermatosis ": 135.68739277990338, "Photophobia ": 2.191131781915289, "Photopsia ": 5.974649759405092, "Photosensitivity reaction ": 42.82782057483317, "Pneumonia fungal ": 16.482551629034095, "Polyneuropathy ": 3.3405895687499347, "Posterior reversible encephalopathy syndrome ": 3.1651550451971406, "Procalcitonin increased ": 28.95326954922581, "Product use in unapproved indication ": 2.3142966159196474, "Pseudomonas infection ": 4.730976282542804, "Pseudoporphyria ": 300.1623556152388, "Pulmonary mass ": 4.282430518265219, "Pulmonary mucormycosis ": 127.70810980739692, "Renal impairment ": 2.7864502866202034, "Respiratory failure ": 3.9548621549662863, "Restlessness ": 2.121572359881645, "Rhabdomyolysis ": 2.861615606029979, "Scedosporium infection ": 79.74604688162609, "Septic shock ": 3.4798675389559897, "Skin disorder ": 3.142508081839344, "Skin lesion ": 3.1239454473472112, "Squamous cell carcinoma ": 28.479407296174777, "Squamous cell carcinoma of skin ": 95.47253107069452, "Systemic candida ": 26.521956508645875, "Therapeutic response decreased ": 2.779059586604084, "Therapy non-responder ": 2.206788399979437, "Torsade de pointes ": 8.95837744414638, "Toxic epidermal necrolysis ": 3.840935485416468, "Toxic optic neuropathy ": 98.11416738541432, "Transaminases increased ": 3.703404458461821, "Treatment failure ": 6.608721316496911, "Ventricular extrasystoles ": 2.5093890697269887, "Vision blurred ": 3.728147057338634, "Visual impairment ": 4.336999119729569, "Vitreous floaters ": 4.663987563718454, "Xanthopsia ": 62.95058771245306} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1159.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1159.json new file mode 100644 index 00000000000..82c975b2c85 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1159.json @@ -0,0 +1 @@ +{"Akathisia ": 18.435545141214945, "Anxiety ": 2.948017995130213, "Completed suicide ": 11.438855501790384, "Condition aggravated ": 4.214090537624172, "Constipation ": 4.492642317966971, "Cough ": 2.38680569926493, "Depression ": 3.577928223883628, "Drug interaction ": 4.033629039292212, "Drug level increased ": 12.777375292865074, "Electrocardiogram QT prolonged ": 6.587641231327645, "General physical health deterioration ": 3.142239720835997, "Hyperhidrosis ": 5.7943674053066045, "Hyponatraemia ": 5.587325299030235, "Insomnia ": 2.0445821955698618, "Irritability ": 17.816496575289133, "Joint swelling ": 3.38548286213186, "Nausea ": 2.431326558267716, "Overdose ": 5.3403495699396695, "Poor quality sleep ": 17.93609851102529, "Product use in unapproved indication ": 2.926132667439656, "Pruritus ": 2.706056077599857, "Serotonin syndrome ": 31.178105101448192, "Sexual dysfunction ": 41.61842060244262, "Sleep disorder ": 4.555933280981491, "Suicidal ideation ": 7.8814558191555, "Toxicity to various agents ": 2.607143829292662, "Tremor ": 2.71015018916042, "Weight increased ": 2.176827815022905} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/116.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/116.json new file mode 100644 index 00000000000..c4dbd2e3ef9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/116.json @@ -0,0 +1 @@ +{"Acute pulmonary oedema ": 60.59716447575847, "Anaemia neonatal ": 364.09945230536647, "Bronchopulmonary dysplasia ": 287.70864136046146, "Congenital arterial malformation ": 1355.953495327631, "Delivery ": 3975.062946982816, "Exposure during pregnancy ": 12.760720574698691, "Foetal exposure during pregnancy ": 50.82404342107393, "Foetal growth abnormality ": 2117.559489195261, "Hyperbilirubinaemia ": 11.585104554602909, "Low birth weight baby ": 51.716120868502806, "Maternal exposure during pregnancy ": 68.47129950844143, "Neonatal hypocalcaemia ": 1996.5794647630812, "Neonatal respiratory distress syndrome ": 108.29782339958244, "Normal labour ": 168024.3977411458, "Oxygen saturation decreased ": 4.237081668099353, "Premature baby ": 146.91602308270248, "Premature delivery ": 631.9486856443345, "Premature rupture of membranes ": 124.85658155349412, "Product use in unapproved indication ": 27.212735058239723, "Pulmonary oedema ": 4.59165045405609, "Respiratory distress ": 9.197036250336888, "Stillbirth ": 98.94594387338395, "Superficial vein thrombosis ": 41.86480049884824, "Tachypnoea ": 15.340977595832918} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1160.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1160.json new file mode 100644 index 00000000000..02464170e62 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1160.json @@ -0,0 +1 @@ +{"Adverse drug reaction ": 4.670840317891651, "Adverse event ": 2.106565205965936, "Ageusia ": 2.773918290459512, "Alanine aminotransferase increased ": 4.2779773441792575, "Amylase increased ": 3.026984729139077, "Angiosarcoma ": 41.77293056198687, "Angiosarcoma metastatic ": 172.01202449436644, "Aspartate aminotransferase increased ": 4.301487648370355, "Azotaemia ": 2.1059066794008943, "Biliary obstruction ": 4.3957767488551465, "Blood albumin decreased ": 2.402585991408558, "Blood alkaline phosphatase increased ": 2.570788700297784, "Blood bilirubin increased ": 7.609380045347937, "Blood creatinine abnormal ": 2.4498793095629003, "Blood pressure increased ": 3.3709184457055352, "Blood sodium decreased ": 2.5845965020242723, "Blood thyroid stimulating hormone increased ": 8.970993236378499, "Blood urine present ": 3.691495286575616, "Bone cancer ": 8.150892251551506, "Bone neoplasm ": 12.676781439013318, "Brain neoplasm ": 6.669036259736003, "Brain neoplasm malignant ": 3.735062733615496, "Cancer pain ": 3.3998452964372072, "Cardiac dysfunction ": 3.0123516808971083, "Cardiac failure ": 2.5651345852774097, "Cardiac failure acute ": 2.144540732028472, "Cardiotoxicity ": 6.360747088098486, "Cataract operation ": 3.102775735170774, "Cell death ": 3.2183904173091102, "Cholecystectomy ": 2.0929049844502297, "Clear cell renal cell carcinoma ": 28.76355627670105, "Death ": 11.220792342365764, "Decreased appetite ": 3.903263948456488, "Dehydration ": 2.7440184002632497, "Dialysis ": 2.6534595252971527, "Diarrhoea ": 3.738781885370754, "Disease progression ": 8.687893699150628, "Dry skin ": 2.319082014165, "Dry throat ": 2.1581839540940706, "Dysgeusia ": 2.4895757228936373, "Eating disorder ": 2.503788838840824, "Ejection fraction decreased ": 9.94933144988663, "Electrolyte imbalance ": 2.1646289537605106, "Emergency care examination ": 16.49954482242419, "Endometrial stromal sarcoma ": 134.39772500777065, "Eyelash discolouration ": 56.772157237581325, "Feeding disorder ": 2.011874490830634, "Fistula ": 3.5527752285482546, "Furuncle ": 2.034606580289052, "Gastric haemorrhage ": 2.406679903127493, "Gastrointestinal perforation ": 7.039805241374208, "Gastrointestinal toxicity ": 3.1475600789309914, "Haemoglobin increased ": 4.348488230098944, "Haemoptysis ": 3.8723978105776578, "Haemorrhage urinary tract ": 4.222287702930135, "Haemorrhoidal haemorrhage ": 3.0485178520053084, "Hair colour changes ": 94.5611094490942, "Hepatic cytolysis ": 3.0587464472888755, "Hepatic enzyme abnormal ": 2.2391631483056647, "Hepatic enzyme increased ": 5.789879291856269, "Hepatic failure ": 4.045896300434097, "Hepatic function abnormal ": 2.362625784607744, "Hepatic lesion ": 2.4030685492749413, "Hepatic neoplasm ": 5.737294089541829, "Hepatitis ": 2.16004884432652, "Hepatitis toxic ": 2.0525038160155784, "Hepatotoxicity ": 13.828756504939784, "Hernia repair ": 5.59520254407644, "Hip surgery ": 7.112025275118933, "Hospice care ": 88.34323587239946, "Hospitalisation ": 9.68227827480804, "Hydronephrosis ": 2.05049387855742, "Hyperbilirubinaemia ": 4.75756366774999, "Hyperkeratosis ": 4.669224456159599, "Hypertension ": 5.059844539222923, "Hypertensive crisis ": 4.912660789291862, "Hypertransaminasaemia ": 8.765312647622824, "Hypoalbuminaemia ": 2.4101799509869903, "Hypothyroidism ": 4.472125644502695, "Ill-defined disorder ": 2.2008259465544318, "Impaired healing ": 2.3266746471993858, "Internal haemorrhage ": 3.032973709693985, "Intestinal perforation ": 9.403325405167545, "Intra-abdominal haemorrhage ": 3.355343304442659, "Jaundice ": 4.473662136858004, "Jaundice cholestatic ": 2.8791658437633068, "Large intestine perforation ": 5.960899245118172, "Left ventricular dysfunction ": 3.168735737032114, "Leiomyosarcoma metastatic ": 128.5271986993595, "Limb operation ": 5.278391815847565, "Lipase increased ": 2.7873366373119564, "Liver disorder ": 2.061150486334104, "Liver function test abnormal ": 3.0682278115770854, "Liver function test increased ": 7.917242524667291, "Living in residential institution ": 21.713913861893857, "Lung abscess ": 4.449351553035297, "Lung neoplasm ": 9.266638596664054, "Lung operation ": 10.66369760815222, "Lymphadenopathy mediastinal ": 3.620643576250691, "Madarosis ": 3.754044316291969, "Malignant connective tissue neoplasm ": 1165.1732247638752, "Malignant neoplasm progression ": 13.28520716586008, "Metastases to adrenals ": 11.730257387447825, "Metastases to bone ": 6.969653136969008, "Metastases to central nervous system ": 13.856136011628116, "Metastases to kidney ": 25.069343267375142, "Metastases to liver ": 6.395487341774149, "Metastases to lung ": 21.48019136910384, "Metastases to lymph nodes ": 6.438153289411878, "Metastases to pancreas ": 22.25127026025585, "Metastases to peritoneum ": 3.611108865173556, "Metastases to skin ": 7.616249199893995, "Metastases to spine ": 9.81058885925851, "Metastasis ": 17.38652411379557, "Metastatic neoplasm ": 11.82295108728882, "Metastatic renal cell carcinoma ": 26.658796092450817, "Mucosal inflammation ": 5.686589905217481, "Neoplasm ": 5.259648947893268, "Neoplasm malignant ": 4.357770247904095, "Nephrectomy ": 8.576910030566427, "Nephrotic syndrome ": 4.746626224643749, "Oral pain ": 2.1067785853905527, "Orthopnoea ": 3.537026681557241, "Osteonecrosis of jaw ": 2.294451649629253, "Palliative care ": 25.405691378746152, "Palmar-plantar erythrodysaesthesia syndrome ": 6.7670847852677065, "Pancreatitis ": 2.1518282849842776, "Pigmentation disorder ": 3.5697638270200724, "Pleural effusion ": 3.7955905366705656, "Pneumothorax ": 21.79921209366731, "Pneumothorax spontaneous ": 13.39582429963201, "Posterior reversible encephalopathy syndrome ": 10.417503973718985, "Proctalgia ": 3.1426266372805896, "Product use in unapproved indication ": 2.9432936615316785, "Protein urine present ": 2.477851817494573, "Proteinuria ": 6.281423010616346, "Pulmonary haemorrhage ": 2.8514412085888394, "Pulmonary mass ": 4.092971664586369, "Pulmonary thrombosis ": 2.405848850274854, "Pyoderma gangrenosum ": 4.510479234840365, "Radiotherapy ": 22.116721311726277, "Rectal abscess ": 12.622624450274008, "Recurrent cancer ": 7.1166075887003535, "Red cell distribution width increased ": 2.5339163914717275, "Regurgitation ": 2.9108483682325774, "Rehabilitation therapy ": 11.638223904488884, "Renal cancer ": 12.652953125544244, "Renal cancer metastatic ": 55.86992310414446, "Renal cancer recurrent ": 67.3760101099884, "Renal cancer stage IV ": 28.274708536600084, "Renal cell carcinoma ": 17.74960585889205, "Renal cell carcinoma stage IV ": 72.01231778799871, "Renal haemorrhage ": 7.647369860480371, "Renal neoplasm ": 10.66152154585468, "Renal surgery ": 65.51764541373763, "Retinal detachment ": 4.794891790434898, "Retinal tear ": 9.127293484818644, "Rhabdomyosarcoma ": 48.498195511699386, "Sarcoma ": 77.62989729937053, "Sarcoma metastatic ": 281.6086071350395, "Second primary malignancy ": 4.516309952548652, "Skin depigmentation ": 6.857300794189839, "Skin discolouration ": 3.3253518754701754, "Skin toxicity ": 4.251833848295403, "Skin ulcer ": 2.5809980532366565, "Soft tissue sarcoma ": 317.1814984074679, "Stomatitis ": 3.571288332668986, "Surgery ": 3.3649221351965504, "Taste disorder ": 5.687004959638173, "Terminal state ": 5.308851107708662, "Thyroid function test abnormal ": 4.674602976227767, "Tongue discomfort ": 2.6302390230282424, "Transaminases increased ": 5.283396322234396, "Transfusion ": 2.1073581788693665, "Tumour excision ": 45.44968984877484, "Tumour haemorrhage ": 9.312143106967412, "Tumour necrosis ": 12.057308322147298, "Tumour pain ": 30.132106336247368, "Urinary bladder haemorrhage ": 4.879666110347417, "Uterine leiomyosarcoma ": 79.10750355765147, "Vena cava thrombosis ": 8.453369409875581, "Ventricular dysfunction ": 5.371430465570555, "Vitreous detachment ": 3.008657789062193, "Weight decreased ": 2.862116427183357, "Yellow skin ": 3.808115026102385} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1161.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1161.json new file mode 100644 index 00000000000..a8df358352d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1161.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 24.820892408198187, "Acute pulmonary oedema ": 42.04640313285206, "Bone marrow failure ": 72.6453326643622, "Cardiac failure ": 3.779580657587427, "Cellulitis ": 9.518420207280547, "Congenital aplasia ": 130.31133910646474, "Cytopenia ": 33.687354447347786, "Disease progression ": 4.415020525486679, "Ejection fraction decreased ": 28.066634161035328, "Febrile neutropenia ": 55.21249773350638, "Infection ": 3.754817677984384, "Neutropenia ": 8.102598659223833, "Neutropenic sepsis ": 138.48004694764285, "Pancytopenia ": 7.139146307915707, "Pneumonia ": 3.997308280556528, "Pneumonia fungal ": 91.18708181728309, "Rash ": 2.7462604746952293, "Rash maculo-papular ": 10.775519792920134, "Sepsis ": 14.025509133946256, "Septic shock ": 10.34632368369127, "Thrombocytopenia ": 5.532761549092627} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1162.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1162.json new file mode 100644 index 00000000000..faab959c3c7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1162.json @@ -0,0 +1 @@ +{"Aggression ": 8.930435894476338, "Anxiety ": 3.897745817976608, "Depression ": 3.248671775367829, "Drug interaction ": 3.393281379710399, "Insomnia ": 5.2608246701273504, "Irritability ": 8.507842657057793, "Nightmare ": 13.11133970060878, "Off label use ": 2.919365000850682, "Suicidal ideation ": 7.910600710596054, "Weight increased ": 3.1680145728063605} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1163.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1163.json new file mode 100644 index 00000000000..b2edb504011 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1163.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 5.693584396010497, "Aspartate aminotransferase increased ": 5.088305198231373, "Blood albumin decreased ": 6.441289094879018, "Blood alkaline phosphatase increased ": 2.523291377501947, "Blood bilirubin increased ": 2.1730741132294216, "Blood potassium increased ": 2.00065086666733, "Bradycardia ": 7.817601448485394, "Cardiac failure ": 2.795446350918977, "Constipation ": 4.290930352864862, "Death ": 7.98864785379812, "Decreased appetite ": 2.2346498787395888, "Disease progression ": 29.897350381351128, "Drug-induced liver injury ": 2.759747176665323, "Dysgeusia ": 3.847660958208119, "Dyspepsia ": 2.206614579092871, "Dysphagia ": 2.721957920702261, "Eating disorder ": 2.673495988593454, "Electrocardiogram QT prolonged ": 7.204074579501508, "Feeding disorder ": 3.2814206874155505, "Fluid retention ": 2.656702451330084, "Gastrooesophageal reflux disease ": 2.146538766138853, "Generalised oedema ": 4.499413095760138, "Haemoptysis ": 2.580986328000739, "Heart rate decreased ": 3.912367495704781, "Hepatic enzyme increased ": 3.6045794617790343, "Hepatic failure ": 3.4069040832345747, "Hepatic function abnormal ": 5.255674747529746, "Hepatitis ": 2.1524371245495257, "Hepatotoxicity ": 10.712764797639675, "Hypertransaminasaemia ": 5.77310332854318, "Interstitial lung disease ": 5.420917694929534, "Liver disorder ": 2.6982119486132814, "Liver function test abnormal ": 2.4478917049008104, "Liver function test increased ": 6.77451798307465, "Liver injury ": 2.6201608926682707, "Lung adenocarcinoma ": 44.00791185422814, "Lung adenocarcinoma stage IV ": 85.52356478007565, "Lung cancer metastatic ": 23.50581052782383, "Lung neoplasm malignant ": 65.06347904480481, "Neoplasm malignant ": 6.995653352001748, "Neoplasm progression ": 55.10796811966359, "Neutropenia ": 2.0999137440753293, "Non-small cell lung cancer ": 94.28499747426464, "Non-small cell lung cancer metastatic ": 149.7730456624511, "Odynophagia ": 3.7569855983701848, "Oedema ": 6.1516870180396825, "Oedema peripheral ": 7.280379713610663, "Oesophageal candidiasis ": 6.359841939999329, "Oesophageal pain ": 8.37860289029666, "Oesophageal ulcer ": 39.54303907059105, "Oesophagitis ": 16.014376240973323, "Pericardial effusion ": 6.813298819426448, "Peripheral swelling ": 2.2426008614593327, "Photopsia ": 29.1764804164103, "Pleural effusion ": 8.049614158492712, "Pneumonia ": 4.06922730623706, "Pneumonitis ": 11.01864522069129, "Product use in unapproved indication ": 4.037267308891923, "Protein total decreased ": 9.520158694719164, "Pulmonary embolism ": 3.251779859054128, "Pulmonary oedema ": 4.487951841546872, "Pulmonary thrombosis ": 4.601415207929729, "Renal abscess ": 63.46430004001686, "Renal cyst ": 16.689673689554763, "Renal impairment ": 3.20733883051391, "Respiratory failure ": 4.1900475124607, "Second primary malignancy ": 10.644337466105158, "Sinus bradycardia ": 7.728385090754297, "Taste disorder ": 6.141023578679089, "Thrombosis ": 2.7876026998942804, "Transaminases increased ": 4.761687797820829, "Vasogenic cerebral oedema ": 64.93326519523193, "Visual impairment ": 5.382014105059722, "Vitreous floaters ": 6.663853560790042, "Vomiting ": 2.2027100398522705} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1164.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1164.json new file mode 100644 index 00000000000..ebfec1372d2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1164.json @@ -0,0 +1 @@ +{"Abdominal wall haematoma ": 19.39152434148882, "Abnormal loss of weight ": 8.345556497234348, "Abnormal uterine bleeding ": 61.50583073755554, "Activated partial thromboplastin time prolonged ": 12.21657314395192, "Acute kidney injury ": 5.271679558945085, "Acute respiratory failure ": 3.711039483353092, "Anaemia ": 2.545106159491493, "Anticoagulation drug level above therapeutic ": 13.327564404483804, "Atrial fibrillation ": 4.146959022064968, "Blood loss anaemia ": 39.12333146256927, "Blood urine present ": 12.087292543389566, "Cardiac failure congestive ": 2.1761115184572914, "Cerebellar haemorrhage ": 10.04960361465968, "Cerebral haematoma ": 13.490481591423986, "Cerebral haemorrhage ": 10.43877444302644, "Cerebral infarction ": 2.1204028019335257, "Cerebral thrombosis ": 8.356462959123247, "Cholestasis ": 2.386691429780636, "Chronic obstructive pulmonary disease ": 2.593022001589105, "Coagulopathy ": 13.740802257186036, "Contusion ": 2.970303125603756, "Deep vein thrombosis ": 7.124183162691977, "Dermatitis bullous ": 2.135694196566929, "Diarrhoea haemorrhagic ": 2.3036907577629604, "Diverticulum intestinal haemorrhagic ": 52.14436765853645, "Drug interaction ": 6.378505066288155, "Duodenal ulcer haemorrhage ": 14.474002180915386, "Ear haemorrhage ": 12.908940136082927, "Ecchymosis ": 4.354286915935052, "Embolic stroke ": 9.72745224184898, "Emphysema ": 2.5593348205418978, "Epistaxis ": 10.310139729868803, "Eye haemorrhage ": 2.640729038651833, "Faeces discoloured ": 2.1264585238691427, "Fall ": 2.2359257654830818, "Gastric haemorrhage ": 3.496552743041361, "Gastric ulcer ": 5.430387260288251, "Gastric ulcer haemorrhage ": 17.499262302920044, "Gastritis haemorrhagic ": 11.77387208209341, "Gastrointestinal haemorrhage ": 35.33280087468717, "Gastrointestinal polyp haemorrhage ": 50.88177702095466, "Gastrointestinal vascular malformation haemorrhagic ": 113.62537844237836, "Gingival bleeding ": 13.3193976871396, "Haemarthrosis ": 13.211687972133172, "Haematemesis ": 7.784884223034125, "Haematochezia ": 4.947048110993616, "Haematoma ": 9.002013364122046, "Haematoma muscle ": 16.142705403003053, "Haematuria ": 19.47667888848008, "Haemoglobin decreased ": 3.1925131517531797, "Haemoptysis ": 11.070736938417404, "Haemorrhage ": 8.218444847100072, "Haemorrhage intracranial ": 10.166937592885102, "Haemorrhage subcutaneous ": 5.863796995998415, "Haemorrhage urinary tract ": 7.389123279562001, "Haemorrhagic arteriovenous malformation ": 245.64703109920376, "Haemorrhagic diathesis ": 8.985751905708424, "Haemorrhagic stroke ": 23.98177836364397, "Haemorrhagic transformation stroke ": 31.698128636877968, "Haemorrhoidal haemorrhage ": 45.96255273256549, "Haemothorax ": 20.66909927323392, "Hemiplegia ": 6.492058862692474, "Hepatitis cholestatic ": 2.341395234823331, "Hypervolaemia ": 3.858669192579097, "Hypovolaemic shock ": 18.02064426702114, "Incorrect dose administered ": 2.4655129228295745, "Increased tendency to bruise ": 9.307048360865997, "Internal haemorrhage ": 91.2080853710169, "International normalised ratio increased ": 9.560471500323258, "Intestinal haemorrhage ": 4.10846404499321, "Intra-abdominal haematoma ": 7.838536786592517, "Iron deficiency anaemia ": 8.015215115181691, "Ischaemic stroke ": 8.512942910284098, "Labelled drug-drug interaction medication error ": 11.869543284749875, "Lactic acidosis ": 2.555879522454513, "Large intestinal haemorrhage ": 15.773913364199675, "Lower gastrointestinal haemorrhage ": 65.06573702400466, "Melaena ": 9.831445625659468, "Mouth haemorrhage ": 10.192896405835326, "Muscle haemorrhage ": 9.088419294248208, "Occult blood positive ": 9.944278996874278, "Pemphigoid ": 2.415875461209798, "Peptic ulcer haemorrhage ": 20.91946217650754, "Pericardial haemorrhage ": 24.289482190610336, "Peripheral artery occlusion ": 11.790499690839017, "Post procedural haemorrhage ": 15.694598329229065, "Prescribed underdose ": 4.39168114912845, "Procedural haemorrhage ": 17.40844868134598, "Product prescribing issue ": 5.062092678220416, "Prothrombin time prolonged ": 12.939366073535084, "Pulmonary alveolar haemorrhage ": 9.978223399768538, "Pulmonary embolism ": 4.876961422887843, "Pulmonary haemorrhage ": 8.910864175538967, "Pulmonary thrombosis ": 5.562793845876686, "Purpura ": 3.444562522533756, "Rectal haemorrhage ": 19.42164022474268, "Renal haemorrhage ": 49.003750226858166, "Respiratory failure ": 2.8781412408089047, "Retroperitoneal haematoma ": 10.66453769730496, "Retroperitoneal haemorrhage ": 13.873805144048994, "Right ventricular failure ": 3.661995248119708, "Shock haemorrhagic ": 20.1780348326518, "Sinus bradycardia ": 2.7091539301764347, "Skin haemorrhage ": 8.552661202606576, "Subarachnoid haemorrhage ": 8.105009312477103, "Subcutaneous haematoma ": 12.316947880461283, "Subdural haematoma ": 12.921724845679815, "Subdural haemorrhage ": 8.478360325915741, "Thalamus haemorrhage ": 12.366845981219775, "Thrombosis ": 3.617483521030592, "Treatment noncompliance ": 2.304010127136201, "Ulcer haemorrhage ": 3.3207938069000185, "Upper gastrointestinal haemorrhage ": 38.24743968432063, "Uterine haemorrhage ": 11.54904791316683, "Vaginal haemorrhage ": 8.649417851682612, "Wound haemorrhage ": 13.521369733008749} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1165.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1165.json new file mode 100644 index 00000000000..e1cd20d5d3c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1165.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 20.09568862652269, "Anuria ": 95.8692694470784, "Hyperkalaemia ": 23.125419839169584, "Hypoglycaemia ": 12.430179345498235, "International normalised ratio increased ": 23.44174657935997, "Pancreatitis acute ": 63.37477913824392} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1166.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1166.json new file mode 100644 index 00000000000..78271f32775 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1166.json @@ -0,0 +1 @@ +{"Abdominal hernia ": 2.884070979605181, "Abnormal faeces ": 2.3928075408709506, "Abscess limb ": 2.5028862684074333, "Accident ": 6.442149234436229, "Accident at work ": 2.915284670566284, "Acne ": 4.823237463049578, "Animal bite ": 7.165849440569597, "Ankle fracture ": 3.9407655637284713, "Ankylosing spondylitis ": 2.155962418203152, "Anorectal disorder ": 2.31115344831101, "Aortic aneurysm ": 2.023304278173464, "Aphonia ": 2.5106125352909108, "Appendicitis perforated ": 4.250554405590314, "Arthritis ": 4.122558377241598, "Arthritis bacterial ": 3.645172554537759, "Arthritis infective ": 14.23639378974735, "Arthropathy ": 3.1563723529350804, "Arthropod bite ": 4.091048236158095, "Back disorder ": 4.741914452090682, "Back injury ": 2.226458195748169, "Bacterial infection ": 2.4603310213299525, "Basal cell carcinoma ": 3.3918565608485305, "Blindness ": 2.273259630781705, "Blood cholesterol abnormal ": 3.745905280483345, "Blood cholesterol increased ": 4.25225725971097, "Blood iron decreased ": 3.3957232138493585, "Blood pressure abnormal ": 2.2257939788563963, "Blood test abnormal ": 2.919178973710866, "Body height decreased ": 4.109398001371105, "Bone deformity ": 6.158186333180558, "Bone disorder ": 3.235768140362503, "Bowel movement irregularity ": 11.483806760524454, "Breast cancer female ": 7.836133796873424, "Bronchial disorder ": 4.440277029508794, "Bronchitis ": 5.287331104733708, "C-reactive protein decreased ": 3.93774690829397, "C-reactive protein increased ": 3.05852073877237, "Cardiac disorder ": 2.105963671589354, "Carpal tunnel syndrome ": 4.703984029745597, "Cartilage injury ": 4.889307878385795, "Cataract ": 4.189898744413058, "Cellulitis ": 3.846776579850049, "Change of bowel habit ": 3.9299829795286216, "Chest injury ": 4.478265966807984, "Chondropathy ": 5.712299736421428, "Circumstance or information capable of leading to medication error ": 2.4535527370356784, "Clostridium difficile infection ": 4.69433192727976, "Coccidioidomycosis ": 10.420758902287782, "Colectomy ": 13.19966951795343, "Colitis ulcerative ": 11.027221022240488, "Colon cancer ": 2.6405366989759216, "Colon injury ": 14.851118906020046, "Colostomy ": 4.496799654131503, "Concussion ": 2.365106357378839, "Condition aggravated ": 9.220630237333856, "Crohn's disease ": 2.335267815459164, "Cyst ": 4.111349649791503, "Cystitis ": 6.146524586519368, "Deafness ": 2.0885520602808274, "Decreased immune responsiveness ": 10.190129969481374, "Defaecation urgency ": 9.216738208184816, "Dementia ": 2.927416845710002, "Dementia Alzheimer's type ": 3.3009719354619595, "Dental operation ": 6.622210238141171, "Dermatomyositis ": 2.6632195864470702, "Diabetes mellitus ": 2.486357079201282, "Diarrhoea haemorrhagic ": 2.7412488547525813, "Discouragement ": 28.66820406371703, "Disease recurrence ": 4.982286237610257, "Diverticulitis ": 7.399989409912882, "Diverticulum ": 2.3447556565832035, "Drug effect less than expected ": 2.338501716279556, "Drug effective for unapproved indication ": 13.777299223054897, "Drug ineffective ": 2.228030949724445, "Dysgraphia ": 3.483490520546, "Dysstasia ": 2.1322661613748064, "Ear disorder ": 2.5114218597751305, "Ear infection ": 4.161845376917523, "Embolism venous ": 2.696699270163605, "Endometrial cancer ": 2.7481922947055986, "Energy increased ": 3.321596396481136, "Enteritis infectious ": 7.408909309555337, "Escherichia infection ": 2.937576579340351, "Exostosis ": 2.3880460237812327, "Exposure to SARS-CoV-2 ": 3.7078327251033394, "Eye disorder ": 2.0845262123786106, "Eye infection ": 7.880904154230506, "Eye operation ": 4.1889883301279385, "Faecal calprotectin increased ": 26.2301529920589, "Faeces pale ": 2.1374552083152025, "Faeces soft ": 4.561286147344739, "Fall ": 3.057350147136144, "Femur fracture ": 3.299674382000317, "Fibromyalgia ": 2.388502466328929, "Fibula fracture ": 2.261601321933054, "Finger deformity ": 10.230879616240076, "Fistula ": 2.5376580673705207, "Flatulence ": 2.3792070588223178, "Food poisoning ": 3.262190697031319, "Foot deformity ": 7.957466409026718, "Foot fracture ": 3.3521393117748315, "Foot operation ": 7.890907341742226, "Frequent bowel movements ": 10.3280252432236, "Frustration tolerance decreased ": 2.380511762342302, "Functional gastrointestinal disorder ": 2.277295271903678, "Fungal foot infection ": 8.168131865810603, "Fungal infection ": 2.864479121445227, "Furuncle ": 3.8110369997639415, "Gait disturbance ": 2.9117528723951662, "Gait inability ": 4.452290267539713, "Gallbladder disorder ": 2.833626593982784, "Gastric infection ": 8.39149014995089, "Gastric ulcer ": 2.1763801075128164, "Gastroenteritis viral ": 3.5509495755776435, "Gastrointestinal disorder ": 2.2797336788872733, "Gastrointestinal infection ": 3.57286524457515, "Gastrointestinal perforation ": 4.026268233561218, "Glaucoma ": 2.380241545511129, "Grip strength decreased ": 3.4731940380903303, "Haematochezia ": 8.015235406559377, "Haemorrhoids ": 2.015264038644923, "Hair growth abnormal ": 2.56609689130473, "Hand fracture ": 2.341637076322997, "Hernia ": 5.032829561481814, "Herpes ophthalmic ": 5.476988279062687, "Herpes virus infection ": 2.4900287144035707, "Herpes zoster ": 3.829311634892809, "Herpes zoster disseminated ": 4.146013822175415, "Hip arthroplasty ": 2.7120839709362485, "Hip fracture ": 4.684246613409992, "Hip surgery ": 5.592309278149666, "Hordeolum ": 3.00115072256945, "Hypoacusis ": 4.139054976746869, "Hypokinesia ": 2.070400302209489, "Ileostomy ": 7.214297757967563, "Illness ": 5.488495275281959, "Immune system disorder ": 6.306799815583306, "Immunodeficiency ": 3.000297820661051, "Immunosuppression ": 11.315393917453394, "Impaired healing ": 2.265580348416136, "Impaired 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6.666711606733356, "Joint lock ": 4.297733580675227, "Joint noise ": 3.4604514031083955, "Joint range of motion decreased ": 3.316824384480165, "Joint stiffness ": 2.5559959006934543, "Joint swelling ": 3.287765766670077, "Kidney infection ": 9.231758312758531, "Knee arthroplasty ": 5.018296032129474, "Knee deformity ": 5.358948337671149, "Knee operation ": 11.376002177893408, "Laboratory test abnormal ": 2.733926354084012, "Lactose intolerance ": 2.913422612802192, "Large intestine infection ": 4.497342833521244, "Laryngitis ": 4.792477064733623, "Latent tuberculosis ": 4.353631065577561, "Ligament rupture ": 7.581175158983913, "Ligament sprain ": 4.783110454910474, "Limb injury ": 6.265018893940134, "Limb mass ": 3.554656696907944, "Limb operation ": 7.807236902522109, "Lipids increased ": 3.841642055216963, "Localised infection ": 9.295619806565076, "Loss of personal independence in daily activities ": 3.2566380396750985, "Loss of therapeutic response ": 4.603716714473935, "Low density lipoprotein increased ": 2.610811890157499, "Lower limb fracture ": 5.522633434697309, "Lower respiratory tract infection ": 7.2083470458330545, "Lumbar spinal stenosis ": 2.5029672295770595, "Lung carcinoma cell type unspecified stage IV ": 3.837127476170201, "Lung disorder ": 2.714603459551626, "Lung neoplasm malignant ": 3.0002753876117234, "Lyme disease ": 4.507230549518414, "Lymphocyte count decreased ": 2.131806248967955, "Lymphoma ": 4.034631811242523, "Malignant melanoma ": 2.5408563090460943, "Mean cell haemoglobin decreased ": 2.676231691943449, "Memory impairment ": 2.848906966970412, "Meniscus injury ": 5.274771973456831, "Middle insomnia ": 2.046899917943348, "Mobility decreased ": 2.66992969279505, "Mucous stools ": 12.605678648686649, "Muscle rupture ": 4.239719702411953, "Muscle strain ": 4.129407348025351, "Musculoskeletal discomfort ": 2.547961877215986, "Musculoskeletal disorder ": 3.435690119569411, "Musculoskeletal stiffness ": 3.2104209048186707, "Mutism ": 2.483974516899671, "Mycobacterial infection ": 2.372770725834075, "Mycobacterium tuberculosis complex test positive ": 4.208125136182243, "Nail infection ": 9.919580006167063, "Nasal congestion ": 2.8640900645122964, "Nasopharyngitis ": 5.251160202437409, "Near death experience ": 2.683142016735039, "Neck surgery ": 5.403019961580301, "Neoplasm ": 2.5127221610796884, "Neoplasm malignant ": 3.900035231921756, "Nephrolithiasis ": 3.671263112618825, "Nerve compression ": 7.295610284416162, "Neuroendocrine carcinoma of the skin ": 5.985781662082982, "Nodule ": 4.307214026731338, "Onychomycosis ": 2.090557649308347, "Ophthalmic herpes zoster ": 4.47859278818176, "Oral herpes ": 2.901829524858127, "Oral infection ": 4.855985979106284, "Oral surgery ": 6.936227928532146, "Osteitis ": 2.3810781968613, "Osteoarthritis ": 6.08990563761232, "Osteomyelitis ": 4.74128264592438, "Pain ": 2.081006176716522, "Pancreatic disorder ": 2.159102279470577, "Parkinson's disease ": 2.0725179632364497, "Patella fracture ": 4.412541845948415, "Pelvic fracture ": 8.05332095859515, "Peripheral swelling ": 2.7673379784818533, "Pharyngeal disorder ": 3.304762953454073, "Pharyngitis streptococcal ": 8.588485839355084, "Plantar fasciitis ": 2.57610753350694, "Pneumonia ": 4.146151799625604, "Pneumonia bacterial ": 2.170113859780184, "Pneumonia fungal ": 2.659072250323589, "Polyarthritis ": 2.855226304939351, "Polyp ": 3.879668448788496, "Post procedural complication ": 4.0430533651762, "Post procedural infection ": 9.684732945782804, "Postoperative wound infection ": 5.953531238236739, "Pre-existing condition improved ": 11.386047523066978, "Precancerous skin lesion ": 7.302423076228181, "Product administration interrupted ": 3.620536614562346, "Product dispensing error ": 4.14149329496209, "Product dispensing issue ": 10.82425487424132, "Product dose omission in error ": 29.36672245036584, "Product dose omission issue ": 4.910272176230133, "Product prescribing error ": 3.9116832129130055, "Product prescribing issue ": 4.481664173472336, "Product use issue ": 2.051342810626262, "Pulmonary fibrosis ": 2.2105525860488893, "Pulmonary mass ": 2.1888785552435923, "Pulmonary thrombosis ": 4.894800127737206, "Pyelonephritis acute ": 2.029372542820046, "Rectal haemorrhage ": 3.4501137642808084, "Red blood cell sedimentation rate increased ": 7.057728448592082, "Red cell distribution width increased ": 3.271684946576185, "Renal disorder ": 2.0332118673671187, "Respiratory tract congestion ": 3.1055729765434616, "Respiratory tract infection ": 5.279892682188207, "Rheumatoid arthritis ": 9.684068297605616, "Rheumatoid factor increased ": 4.314748161567954, "Rheumatoid lung ": 15.22532435086121, "Rheumatoid nodule ": 3.206396668823501, "Rhinorrhoea ": 2.3054221947515545, "Rib fracture ": 4.5029789902352455, "Road traffic accident ": 2.4557194737462376, "Root canal infection ": 15.596516280448414, "Rosacea ": 3.603283907128744, "Rotator cuff repair ": 7.315733578436119, "Rotator cuff syndrome ": 3.5603245042153384, "Sciatica ": 3.3862265188673946, "Seasonal allergy ": 2.3212835767437463, "Secretion discharge ": 2.0137728171923617, "Sensitivity to weather change ": 74.79239676759381, "Serum ferritin decreased ": 4.377714024717936, "Shoulder arthroplasty ": 6.910809620132806, "Shoulder fracture ": 5.785637192367399, "Shoulder operation ": 7.963545249038041, "Sinus congestion ": 3.0791369909766315, "Sinus disorder ": 5.123468849937683, "Sinusitis ": 5.764374498323321, "Sinusitis bacterial ": 11.755807438517715, "Sjogren's syndrome ": 5.333683861475484, "Skin cancer ": 12.087827958796744, "Skin infection ": 5.163054535036357, "Skin laceration ": 2.1743684834052988, "Skin lesion ": 2.1867895003365008, "Skin papilloma ": 2.422605519046233, "Spinal column injury ": 2.1681627589116794, "Spinal disorder ": 5.826334056620661, "Spinal fracture ": 4.879635386933575, "Spinal fusion surgery ": 4.389588832457066, "Spinal operation ": 8.364108399666158, "Spinal osteoarthritis ": 2.2351817474495044, "Spinal stenosis ": 4.517192979728206, "Spondylitis ": 3.2989709352108663, "Squamous cell carcinoma ": 2.99282341411217, "Squamous cell carcinoma of skin ": 2.87892501999679, "Staphylococcal infection ": 3.131550994475061, "Stress ": 4.406089547947764, "Stress fracture ": 3.172593327144537, "Synovial cyst ": 7.054134386319614, "Synovitis ": 2.197546493024581, "Therapeutic product effect delayed ": 12.894914124803362, "Therapeutic product effect incomplete ": 10.417660906176646, "Therapeutic response shortened ": 3.0174436655285883, "Therapeutic response unexpected ": 4.032725508487449, "Thrombosis ": 2.900543624967113, "Tibia fracture ": 2.723597235907611, "Tooth abscess ": 12.1726670781839, "Tooth disorder ": 2.827571185794042, "Tooth infection ": 9.754547732061573, "Trigger finger ": 8.09978296135574, "Tuberculin test positive ": 4.125715514569197, "Tuberculosis ": 6.060448717697112, "Ulcer ": 2.081045508166849, "Upper limb fracture ": 5.47997362201795, "Upper respiratory tract congestion ": 3.7915813868841135, "Upper respiratory tract infection ": 4.699784227846555, "Urinary tract infection ": 5.311379665112381, "Urinary tract infection bacterial ": 5.656062041954677, "Vaginal infection ": 2.2908939980981144, "Vein rupture ": 3.354917183704217, "Viral infection ": 4.501724042068621, "Viral upper respiratory tract infection ": 4.731834105090763, "Vitamin D decreased ": 3.325154002157109, "Walking aid user ": 2.885538718455632, "Weight fluctuation ": 2.109185385587176, "Weight increased ": 2.4089663270010178, "Wound infection ": 6.106069231784663, "Wound secretion ": 4.196760124655299, "Wrist fracture ": 3.844355607509263, "Wrong dose ": 2.282167278670006} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1167.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1167.json new file mode 100644 index 00000000000..7d24bdd45d3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1167.json @@ -0,0 +1 @@ +{"Angina pectoris ": 2.2384108583098943, "Blood bilirubin increased ": 2.362730285734237, "Cardiotoxicity ": 8.364532985830472, "Colitis ": 2.2421253890274877, "Cytopenia ": 3.4056755886808654, "Decreased appetite ": 3.037550371822953, "Dehydration ": 5.500518065546097, "Diarrhoea ": 5.185923765483005, "Dihydropyrimidine dehydrogenase deficiency ": 558.2720644150886, "Disease progression ": 3.4205536594812105, "Disseminated intravascular coagulation ": 4.980523480836592, "Drug interaction ": 3.062848114406834, "Drug-induced liver injury ": 2.481271883611569, "Enteritis ": 13.7171912538231, "Enterocolitis ": 15.604784290694685, "Faecal volume decreased ": 255.86707061670367, "Febrile neutropenia ": 4.032253310476976, "Formication ": 4.762352058622428, "Gastrointestinal disorder ": 2.898946129614268, "Granulocyte count decreased ": 20.84968282235198, "Granulocytopenia ": 9.202547515220974, "Hepatic function abnormal ": 6.779865604880881, "Hepatic lesion ": 9.691426315849826, "Hyperbilirubinaemia ": 3.171059135469399, "Ileus ": 5.047902978645126, "Intentional product use issue ": 2.107817980361163, "International normalised ratio increased ": 4.347527932144155, "Interstitial lung disease ": 2.612142748915216, "Intestinal obstruction ": 2.724589771920116, "Leukoencephalopathy ": 12.439607280393512, "Leukopenia ": 3.282350316287402, "Liver injury ": 2.1875435848493927, "Metastases to liver ": 2.7565281006463964, "Mouth ulceration ": 2.1701152747591235, "Mucosal inflammation ": 12.440914443245743, "Myelosuppression ": 58.189299880052815, "Neuropathy peripheral ": 5.415522268494856, "Neurotoxicity ": 7.1808520378960266, "Neutropenia ": 6.094062686874297, "Neutrophil count decreased ": 15.836277166201668, "Palmar-plantar erythrodysaesthesia syndrome ": 21.2059160599237, "Pancytopenia ": 3.3775782223168496, "Platelet count decreased ": 18.03954869374636, "Polyneuropathy ": 3.27974274011786, "Prothrombin time prolonged ": 8.384464030534312, "Retching ": 2.153909571237612, "Sensory disturbance ": 2.5989980533656034, "Sepsis ": 2.075543772288573, "Septic shock ": 3.3915362479540616, "Stomatitis ": 5.051706541413796, "Thrombocytopenia ": 4.976672853500907, "Vomiting ": 2.9144658389496474, "White blood cell count decreased ": 12.905969957567365} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1168.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1168.json new file mode 100644 index 00000000000..cff584ea66e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1168.json @@ -0,0 +1 @@ +{"Drug interaction ": 32.58711593822185, "Drug level decreased ": 155.18513374722136, "International normalised ratio increased ": 19.50159743590104, "Renal failure ": 2.9713598274169324} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1169.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1169.json new file mode 100644 index 00000000000..72bd17c9d75 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1169.json @@ -0,0 +1 @@ +{"Completed suicide ": 4.033331950118586, "Drug interaction ": 2.736196017149354, "Electrocardiogram QT prolonged ": 6.694905452022044, "Extrapyramidal disorder ": 53.19828458071488, "Neuroleptic malignant syndrome ": 37.12060238203841, "Overdose ": 2.8464849965704224, "Product use in unapproved indication ": 2.3756402356931456, "Psychiatric symptom ": 61.4738604159204, "Psychotic disorder ": 20.386707798002, "Restlessness ": 8.8291692842702, "Rhabdomyolysis ": 11.90145791408296, "Schizophrenia ": 108.64342338680372, "Suicidal ideation ": 4.61463585452843, "Suicide attempt ": 7.852130505708266, "Weight increased ": 4.929064803427889} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/117.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/117.json new file mode 100644 index 00000000000..96e50ddf04c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/117.json @@ -0,0 +1 @@ +{"Neutropenia ": 26.723945494716958, "Pyrexia ": 3.738393341933047} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1170.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1170.json new file mode 100644 index 00000000000..469bc192700 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1170.json @@ -0,0 +1 @@ +{"Diarrhoea ": 8.022891568732133} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1171.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1171.json new file mode 100644 index 00000000000..4d9cb7e2c16 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1171.json @@ -0,0 +1 @@ +{"Back pain ": 2.935845632824664, "Hot flush ": 10.009537814005284, "Hypocalcaemia ": 45.58729986690024, "Malignant neoplasm progression ": 7.224431708774694, "Metastases to bone ": 23.43139547256248, "Osteonecrosis of jaw ": 189.02555822628665, "Prostatic specific antigen increased ": 76.98881335539022} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1172.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1172.json new file mode 100644 index 00000000000..90b823e47d8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1172.json @@ -0,0 +1 @@ +{"Dupuytren's contracture ": 1015.0574975032964, "Haematoma ": 29.5885108338494, "Hypersensitivity ": 3.46007082119764, "Pain in extremity ": 2.0482966017415256, "Penile contusion ": 5477.844931612342, "Penile haematoma ": 2783.614869252263, "Penile pain ": 436.1699933696145, "Penile swelling ": 1571.5565979304415, "Peripheral swelling ": 6.27675194293081, "Skin laceration ": 81.29900011033402, "Tendon rupture ": 100.7051940880498} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1173.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1173.json new file mode 100644 index 00000000000..bdcbed27203 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1173.json @@ -0,0 +1 @@ +{"Lactic acidosis ": 76.28632593236019} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1174.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1174.json new file mode 100644 index 00000000000..7f631a6b5c6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1174.json @@ -0,0 +1 @@ +{"Platelet count decreased ": 33.93475477427325} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1175.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1175.json new file mode 100644 index 00000000000..fa7a7bb214c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1175.json @@ -0,0 +1 @@ +{"Anaemia ": 9.07720204718618, "Bedridden ": 2.886133874536462, "Blood alkaline phosphatase decreased ": 168.24900498148753, "Blood alkaline phosphatase increased ": 8.514820350451952, "Blood lactate dehydrogenase increased ": 2.1035855469421563, "Blood test abnormal ": 11.552122865732096, "Bone marrow failure ": 11.195563972528, "Bone marrow infiltration ": 191.6961859485745, "Bone pain ": 11.592977078852812, "Cancer pain ": 58.63330464800885, "Cytopenia ": 3.0320461890814507, "Death ": 4.442159241223041, "Decreased appetite ": 2.66011209923953, "Disease progression ": 11.416595869811308, "Disseminated intravascular coagulation ": 3.432885531902864, "Femur fracture ": 3.916114511767302, "Fracture ": 2.385889912485718, "Full blood count abnormal ": 6.235813645803122, "General physical health deterioration ": 19.89063277251192, "Haematotoxicity ": 21.636823630609022, "Haemoglobin abnormal ": 11.868087732710553, "Haemoglobin decreased ": 13.41192386233636, "Hip fracture ": 2.1735032765630296, "Hormone-refractory prostate cancer ": 2531.64539760757, "Hospitalisation ": 2.316762870105822, "Hydronephrosis ": 8.682038977987448, "Laboratory test abnormal ": 5.109347993959273, "Leukopenia ": 3.309170650389392, "Malignant neoplasm progression ": 3.833058014482327, "Metastases to bone ": 106.22421418528654, "Metastases to bone marrow ": 112.18539757329346, "Metastases to central nervous system ": 13.794139072933582, "Metastases to liver ": 46.14883717192665, "Metastases to lung ": 20.97677760725499, "Metastases to lymph nodes ": 39.55039531435719, "Metastases to meninges ": 26.34510649230741, "Metastases to spine ": 72.41624308179424, "Metastasis ": 56.17192846609832, "Musculoskeletal chest pain ": 2.9521658499840675, "Myelosuppression ": 6.721688788318357, "Neutropenia ": 2.575306574065629, "Neutrophil count decreased ": 4.347183286645701, "No adverse event ": 9.26591997490989, "Osteonecrosis of jaw ": 41.595890843858456, "Pancytopenia ": 9.63964719827858, "Pathological fracture ": 42.76582127475856, "Pelvic pain ": 4.167684597142023, "Physical deconditioning ": 6.917627610377852, "Platelet count decreased ": 10.10074188601193, "Pre-existing condition improved ": 25.73337451081017, "Prostate cancer ": 41.50683373793359, "Prostate cancer metastatic ": 274.5854082570385, "Prostate cancer stage IV ": 669.6419292504548, "Prostatic specific antigen increased ": 246.02777608228257, "Red blood cell count decreased ": 3.6771648295936767, "Sepsis ": 2.018308417063776, "Spinal compression fracture ": 15.676576970586376, "Spinal cord compression ": 125.827529060048, "Spinal pain ": 5.5720946801880205, "Subdural haematoma ": 3.644857750081609, "Thrombocytopenia ": 6.969837955676304, "Transfusion ": 5.448950213336653, "Weight decreased ": 2.23881337343016, "White blood cell count decreased ": 3.423085248372752} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1176.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1176.json new file mode 100644 index 00000000000..a939ddf0f46 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1176.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 4.235924985411844, "Allergy to animal ": 5.336252706063613, "Anaphylactic reaction ": 12.053879170124592, "Anaphylactoid reaction ": 3.496956817012715, "Angioedema ": 4.969808796998703, "Antinuclear antibody positive ": 2.757847378933025, "Aphonia ": 3.0061926110009853, "Asthma ": 17.399260804877425, "Asthmatic crisis ": 15.189563851014636, "Atypical pneumonia ": 3.3041485295367634, "Blood immunoglobulin E abnormal ": 110.40345288820612, "Blood immunoglobulin E decreased ": 73.89204220973382, "Blood immunoglobulin E increased ": 51.41391733544492, "Blood immunoglobulin G decreased ": 4.002424426005726, "Blood pressure diastolic decreased ": 2.381075546271854, "Blood pressure systolic increased ": 2.830253663699947, "Body temperature decreased ": 2.679584000995417, "Breast cancer ": 3.7785167452857, "Breast conserving surgery ": 6.142662017505936, "Breast mass ": 3.008872779811941, "Breast neoplasm ": 7.519044519746774, "Breath sounds abnormal ": 5.307364265968516, "Bronchial secretion retention ": 3.392692037356375, "Bronchiectasis ": 2.431348778599655, "Bronchitis ": 5.29452505358948, "Bronchitis chronic ": 3.5212798120886037, "Bronchopulmonary aspergillosis allergic ": 7.645767157499886, "Bronchospasm ": 6.079094022198634, "Chest discomfort ": 4.4194928818101, "Choking ": 2.697133503589303, "Choking sensation ": 2.782763696931359, "Chronic obstructive pulmonary disease ": 2.6170288884405863, "Chronic spontaneous urticaria ": 90.44937830054408, "Circumoral oedema ": 7.747470057477846, "Colon cancer ": 2.895647900133583, "Computerised tomogram abnormal ": 5.262822873659927, "Concomitant disease aggravated ": 3.315331822590602, "Coronavirus infection ": 2.790707510922037, "Cough ": 3.3632653157018115, "Cystic fibrosis ": 3.899683002506681, "Dermatitis atopic ": 6.10030137690918, "Diffuse alopecia ": 2.6869496960160277, "Dysphonia ": 2.6851119115028546, "Dyspnoea ": 2.9302373032031803, "Dyspnoea exertional ": 2.1145989537354444, "Ear infection ": 3.040112373374012, "Ear swelling ": 2.5926258146026218, "Enlarged uvula ": 6.504797389452493, "Eosinophil count increased ": 5.476101458511203, "Eosinophilic granulomatosis with polyangiitis ": 16.741397252534668, "Eosinophilic oesophagitis ": 6.299321516974139, "Eye oedema ": 3.103130538697072, "Eye pruritus ": 4.486953457092273, "Eye swelling ": 2.607784550082871, "FEV1/FVC ratio decreased ": 74.0900143252954, "Flushing ": 3.7167230737031383, "Food allergy ": 4.486514102666203, "Forced expiratory volume decreased ": 29.310949396213665, "Frustration tolerance decreased ": 3.0572908959121645, "Gastroenteritis viral ": 2.138554759247791, "Heart rate increased ": 2.371493000048711, "Human anti-human antibody test ": 156.16425587215184, "Hypersensitivity ": 3.334261641298798, "Hyperventilation ": 4.153475508116762, "Hypoventilation ": 9.901946952078251, "Idiopathic urticaria ": 24.82710464781455, "Incorrect route of product administration ": 3.1794267996872017, "Increased upper airway secretion ": 2.716521190795712, "Infection parasitic ": 14.404427049283964, "Infectious mononucleosis ": 3.316866878219124, "Injection site oedema ": 2.788245982201012, "Injection site rash ": 2.0114252623578666, "Injection site reaction ": 2.1324345902204658, "Injection site urticaria ": 5.925211167070972, "Intraductal proliferative breast lesion ": 5.399930913896246, "Invasive ductal breast carcinoma ": 2.794409469416894, "Lacrimation increased ": 2.6458595144824386, "Laryngeal oedema ": 3.921325090860384, "Laryngitis ": 2.761500365448212, "Ligament rupture ": 3.2013016684220634, "Ligament sprain ": 3.8122382356983993, "Lip swelling ": 4.252408121442034, "Lower respiratory tract infection ": 2.619215877332144, "Lung adenocarcinoma ": 5.475644854129506, "Lung disorder ": 2.1207053982336586, "Lung neoplasm malignant ": 2.021281790340965, "Lymphoma ": 3.184390382058309, "Malignant melanoma ": 2.1604329481759623, "Mast cell activation syndrome ": 8.266462843097395, "Mastectomy ": 4.165933766731786, "Maternal exposure during pregnancy ": 3.8061345723664624, "Middle insomnia ": 3.682727916880797, "Mouth swelling ": 2.278699143611436, "Nasal congestion ": 4.818888881202088, "Nasal polyps ": 5.865389581311857, "Nasopharyngitis ": 3.508971402582956, "Needle issue ": 6.233384332184372, "Neutrophil count increased ": 2.5332110599457502, "Normal newborn ": 14.595419058219372, "Obstructive airways disorder ": 5.655817256685253, "Oesophageal spasm ": 5.055931464545518, "Oropharyngeal pain ": 2.134960302884575, "Oropharyngeal swelling ": 5.334275528398657, "Paranasal sinus discomfort ": 2.3568381766486555, "Peak expiratory flow rate decreased ": 39.524262476685344, "Pharyngeal disorder ": 4.549457264915034, "Pharyngeal oedema ": 2.791571589983282, "Pharyngeal swelling ": 5.751740422515013, "Pharyngitis ": 2.452025554320373, "Pharyngitis streptococcal ": 2.425971990554596, "Pigmentation disorder ": 2.2232093522323515, "Pleural rub ": 121.40023571606756, "Pneumonia ": 2.557268297172824, "Polyp ": 2.047137667216888, "Postoperative wound infection ": 2.118523083237267, "Product supply issue ": 2.5835795722786825, "Productive cough ": 7.555071575066395, "Pruritus ": 2.642180799900074, "Pulmonary congestion ": 6.035381876711719, "Pulmonary function test decreased ": 11.295100128559682, "Pulmonary mass ": 3.007078089172426, "Rales ": 2.939297022574942, "Respiratory disorder ": 3.409257585453896, "Respiratory distress ": 2.2562026105387103, "Respiratory rate increased ": 5.157380116918331, "Respiratory tract congestion ": 11.02649695039315, "Respiratory tract infection ": 4.308261556089283, "Rhinitis ": 2.456566342968939, "Rhinorrhoea ": 2.344692654500089, "Rhonchi ": 9.19097870107115, "Rubber sensitivity ": 7.043352307243448, "Scratch ": 4.281244513369621, "Seasonal allergy ": 4.112645436382335, "Secretion discharge ": 4.859287380261092, "Sensation of foreign body ": 3.1418626587713843, "Sensitivity to weather change ": 6.485839434529864, "Serum sickness ": 25.031819764707457, "Serum sickness-like reaction ": 10.77172523023931, "Sinus congestion ": 7.812264648315513, "Sinus disorder ": 4.006661407798301, "Sinus operation ": 7.436710230346999, "Sinusitis ": 4.743780779947715, "Skin infection ": 3.342033417534267, "Skin lesion ": 2.280642946835563, "Skin oedema ": 5.874135795690657, "Skin plaque ": 4.687672818951868, "Skin sensitisation ": 7.046871761810538, "Skin swelling ": 3.0656877192478333, "Sneezing ": 4.156687875883475, "Spirometry abnormal ": 9.540569282855714, "Sputum discoloured ": 16.468371354490174, "Sputum increased ": 2.3035979674062435, "Sputum retention ": 4.97966480795533, "Stillbirth ": 2.539588048741906, "Streptococcal infection ": 2.333086403524534, "Stress ": 2.065344037271125, "Stridor ": 5.414520676846805, "Suffocation feeling ": 2.384472788429843, "Swelling face ": 3.153603937995646, "Swelling of eyelid ": 2.02944239045929, "Swollen tongue ": 3.8450131494927584, "Symptom recurrence ": 3.3462164605735776, "Syringe issue ": 4.5638630696758895, "Temperature intolerance ": 2.987774435861719, "Throat clearing ": 7.0406736085255845, "Throat irritation ": 4.394188159004771, "Throat tightness ": 7.456707910602027, "Thyroid cancer ": 2.2299419951494794, "Tongue disorder ": 2.40085035171356, "Type I hypersensitivity ": 4.032933074165289, "Type III immune complex mediated reaction ": 9.123314363409628, "Upper airway obstruction ": 19.60295950321052, "Upper limb fracture ": 2.070160168182349, "Upper respiratory tract congestion ": 4.333657040116179, "Upper respiratory tract infection ": 3.282196683747181, "Upper-airway cough syndrome ": 4.361711039263777, "Urticaria ": 6.430045808586802, "Urticaria chronic ": 3.624366755925291, "Urticarial vasculitis ": 13.52977861737449, "Viral infection ": 4.297590070120743, "Weight increased ": 2.3426226883093952, "Wheezing ": 12.40408352587772, "White blood cell count increased ": 2.229889542836527} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1177.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1177.json new file mode 100644 index 00000000000..aa4f1883b58 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1177.json @@ -0,0 +1 @@ +{"Amnesia ": 2.4786911840725074, "Aortic dissection ": 2.5107483294547484, "Asthenia ": 2.446456551696473, "Back pain ": 2.982876412686557, "Balance disorder ": 2.409506461859013, "Bedridden ": 2.6162967607047487, "Bladder disorder ": 2.411278278563966, "Blood urine present ": 10.157948898610009, "Bone cancer ": 19.7788821453022, "Bone lesion ": 3.5066149558470143, "Bone pain ": 3.758905539395671, "Cancer pain ": 19.53471988627772, "Cerebrovascular accident ": 2.005672820550863, "Choking ": 3.0075903289379786, "Cognitive disorder ": 3.513692213241961, "Compression fracture ": 4.798983212938757, "Constipation ": 3.232921755092056, "Cystitis ": 2.7696308003593666, "Death ": 11.995366495415595, "Decreased appetite ": 5.038737498830942, "Decreased interest ": 3.500845114834425, "Dehydration ": 2.105359393334997, "Dementia ": 4.215567406105599, "Dementia 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"Hypersomnia ": 3.345165253333059, "Hypogeusia ": 2.106872608271572, "Illness ": 2.0692474149456146, "Incontinence ": 2.3260090743721022, "Intentional dose omission ": 11.041481994955625, "Intentional underdose ": 17.542703145611828, "International normalised ratio decreased ": 2.6843084356349656, "Kidney infection ": 2.464779679548623, "Malignant neoplasm progression ": 33.76219057946895, "Memory impairment ": 3.0024892426353595, "Metastases to bone ": 9.678539324149195, "Metastases to central nervous system ": 2.042302060067424, "Metastases to spine ": 5.766791176801762, "Metastasis ": 6.664261700612534, "Metastatic neoplasm ": 2.5766044654416627, "Muscular weakness ": 2.495394483175778, "Neoplasm ": 2.78309094623456, "Nocturia ": 4.564941828923853, "Oncologic complication ": 17.07118321948716, "Pathological fracture ": 2.305351023381109, "Performance status decreased ": 2.2526829574376426, "Peripheral swelling ": 2.492510051591361, "Physical deconditioning ": 2.315673831297754, "Pneumonia aspiration ": 2.079228066426385, "Pollakiuria ": 3.2310860258787715, "Posterior reversible encephalopathy syndrome ": 5.153549072430196, "Prescribed underdose ": 15.400983405917302, "Product availability issue ": 2.802395357476865, "Product dose omission issue ": 3.5060257632232683, "Product physical issue ": 2.810342116830472, "Product size issue ": 157.7860447798756, "Product use complaint ": 14.154089949971391, "Prostate cancer ": 10.816870647420302, "Prostate cancer metastatic ": 23.287040880013382, "Prostate cancer recurrent ": 16.770769596990146, "Prostatic specific antigen abnormal ": 105.7858051350146, "Prostatic specific antigen increased ": 236.49024028387117, "Regurgitation ": 2.222294789879967, "Restless legs syndrome ": 5.586587972308941, "Rib fracture ": 2.897442286644785, "Seizure ": 2.361213584828544, "Shoulder fracture ": 3.944255454997076, "Sinus disorder ": 2.6194753839403355, "Spinal compression fracture ": 3.104267528445399, "Spinal cord compression ": 10.221922409564849, "Spinal cord neoplasm ": 16.244264038495704, "Spinal operation ": 2.4496477590400207, "Stent placement ": 4.0106960763241775, "Taste disorder ": 3.697972778776074, "Terminal state ": 13.890725342976491, "Throat cancer ": 2.4759666002173493, "Tooth extraction ": 2.065093327589126, "Treatment noncompliance ": 5.955133806365104, "Underdose ": 33.0552666161666, "Upper limb fracture ": 3.156395475389211, "Ureteric obstruction ": 7.205096110626176, "Urinary bladder haemorrhage ": 6.414623725004774, "Urinary incontinence ": 2.1573132057832267, "Urinary tract disorder ": 2.7969391403258377, "Urinary tract infection ": 3.265964861724747, "Urinary tract obstruction ": 5.677076881147115, "Vascular graft ": 4.104576591490448, "Walking aid user ": 2.140420282989459, "Walking disability ": 2.150272596352453, "Weight decreased ": 3.365319771544744, "Wrong technique in product usage process ": 2.234417457183803} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1178.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1178.json new file mode 100644 index 00000000000..7ea6f81fce6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1178.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 2.562222455144273, "Abnormal dreams ": 8.91516435096831, "Abnormal sleep-related event ": 109.88972220291755, "Adverse drug reaction ": 2.341548170670347, "Agitation ": 4.6827162084615965, "Amnesia ": 2.1995343898763675, "Anger ": 2.2570229130518658, "Anxiety ": 4.678931396658194, "Apnoea ": 3.7164870615315473, "Arthritis ": 2.431628755455323, "Back disorder ": 8.387743550887034, "Bipolar disorder ": 6.017577541938056, "Blood potassium decreased ": 5.348963562480917, "Blood pressure increased ": 2.8783708844042546, "Blood sodium decreased ": 2.5091136657630977, "Brain fog ": 2.345878159167349, "Breath holding ": 93.9842839999692, "Bronchitis ": 2.745425383566882, "Cataplexy ": 484.90612104083385, "Coma ": 2.4178254001898605, "Conduction disorder ": 21.35360636598173, "Delusion ": 5.735166811737682, "Depressed level of consciousness ": 5.4372118707299295, "Depression ": 5.542094687141068, "Drug abuse ": 2.331073061463816, "Drug hypersensitivity ": 3.960839652326516, "Drug screen positive ": 26.8361402461562, "Drug withdrawal syndrome ": 2.070564829784533, "Dry eye ": 2.591655121507472, "Electrolyte imbalance ": 7.033362324740189, "Enuresis ": 55.01823440148234, "Eye haemorrhage ": 3.0555226287267105, "Fall ": 2.997594295639119, "Feeling abnormal ": 4.958327086551993, "Feeling drunk ": 9.496381190061712, "Feeling jittery ": 23.63650974650078, "Fibromyalgia ": 6.786034529679121, "Foot fracture ": 2.2089337026026463, "Gastritis ": 2.142776586231483, "Hallucination ": 3.638520376701773, "Hangover ": 15.869527954881004, "Head injury ": 2.781333811644462, "Heart rate decreased ": 2.018743809974245, "Hunger ": 7.412476807352304, "Hypertension ": 2.9746574395676864, "Initial insomnia ": 12.422226735229687, "Insomnia ": 2.416921029873992, "Intentional product misuse ": 3.5747610497699687, "Intentional product use issue ": 3.297483072452432, "Intervertebral disc degeneration ": 5.197283268681771, "Intervertebral disc protrusion ": 7.969155623542485, "Irritability ": 4.259291997258726, "Joint dislocation ": 5.122601361281031, "Joint injury ": 4.204518378548572, "Lethargy ": 3.511171568626322, "Limb injury ": 3.89101592731847, "Mania ": 3.17662604767393, "Memory impairment ": 3.484801502040036, "Migraine ": 2.75245547697651, "Mood altered ": 2.380997367637278, "Muscle tightness ": 6.2617087744399615, "Narcolepsy ": 49.08378363190105, "Nephrolithiasis ": 3.2683663559732485, "Nervousness ": 5.17106940957871, "Neuralgia ": 2.436432241168069, "Nightmare ": 2.909004273096369, "Obsessive-compulsive disorder ": 5.763962290003075, "Obstructive sleep apnoea syndrome ": 22.398941260294063, "Overdose ": 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unexpected ": 13.325031925648712, "Thinking abnormal ": 3.0482230245428847, "Tooth disorder ": 5.840999857338879, "Tremor ": 2.7968803022383324, "Unevaluable event ": 17.527563031262044, "Weight decreased ": 5.238743742022834, "Weight increased ": 2.19969086193454, "Wrong technique in product usage process ": 2.882598558017876} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1179.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1179.json new file mode 100644 index 00000000000..c5fea50027d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1179.json @@ -0,0 +1 @@ +{"Adrenal disorder ": 21.74454274747636, "Adrenal insufficiency ": 20.863380297241548, "Adrenocortical insufficiency acute ": 21.3103035724141, "Adverse event ": 5.021723104558758, "Autoimmune colitis ": 250.55159493718256, "Autoimmune hepatitis ": 27.81665257726338, "Blood sodium decreased ": 2.480488946750292, "Blood thyroid stimulating hormone decreased ": 15.645556184679588, "Colitis ": 106.40084007570152, "Colitis ulcerative ": 4.756232395930666, "Conjunctivitis ": 3.0194215175323427, "Death ": 7.314046515584372, "Dehydration ": 2.942478250078489, "Dermatitis ": 2.7729989938775077, "Diarrhoea ": 5.71360276227037, "Diarrhoea haemorrhagic ": 7.462390705172848, "Encephalitis ": 3.6112130804300513, "Endocrine disorder ": 46.589106690286464, "Enteritis ": 6.830994180042691, "Enterocolitis ": 80.62849752865445, "Enterocolitis haemorrhagic ": 37.19148447662393, "General physical health deterioration ": 2.561426451371126, "Guillain-Barre syndrome ": 4.97783944956507, "Hepatic cytolysis ": 3.0311805394802147, "Hepatic failure ": 4.671356820221756, "Hepatitis ": 8.581449838269881, "Hepatotoxicity ": 6.895680990131609, "Hospitalisation ": 2.899782529060089, "Hyperthyroidism ": 3.9315876592628114, "Hypertransaminasaemia ": 6.916256578616816, "Hypophysitis ": 349.16454064114987, "Hypopituitarism ": 131.1982648591851, "Hypothalamo-pituitary disorder ": 56.0289313002347, "Hypothyroidism ": 5.031543586318606, "Immune-mediated enterocolitis ": 9.312142354077356, "Intentional product use issue ": 3.471437852717989, "Intestinal perforation ": 62.87074018415184, "Large intestine perforation ": 33.74146528597284, "Liver disorder ": 2.1825646687641305, "Liver function test increased ": 3.66705152791576, "Lymphocytic hypophysitis ": 83.95034300033848, "Malignant melanoma ": 2.4404107321332678, "Malignant neoplasm progression ": 52.809348812424254, "Meningitis ": 6.01690293636279, "Metastases to central nervous system ": 44.140995296166736, "Metastases to liver ": 3.2572757699936377, "Metastases to lung ": 6.801163194434338, "Metastasis ": 6.750475518621078, "Neoplasm ": 5.372987939217346, "Neuropathy peripheral ": 2.409754364521019, "Peritonitis ": 6.7155303973396485, "Pleural effusion ": 2.1793372659633947, "Pneumonitis ": 7.427405654605455, "Prescribed overdose ": 32.797987113559344, "Sepsis ": 2.089961680948217, "Thyroid disorder ": 6.7735081084961655, "Thyroiditis ": 6.955764566201648, "Uveitis ": 5.682803675190282, "Vitiligo ": 30.315521759509934, "Weight decreased ": 2.176922518401426} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/118.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/118.json new file mode 100644 index 00000000000..fe53bf9b0d8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/118.json @@ -0,0 +1 @@ +{"Acquired immunodeficiency syndrome ": 4.597739131253828, "Acute kidney injury ": 4.097210202902976, "Agoraphobia ": 2.5058549132211643, "Albuminuria ": 4.004929530804365, "Alveolar bone resorption ": 17.917449050920517, "Anaemia of chronic disease ": 2.719320791645615, "Anhedonia ": 62.04720501322591, "Ankle fracture ": 20.673477754037624, "Anxiety ": 9.981756945498146, "Avulsion fracture ": 24.29589967410996, "Blood creatine increased ": 4.103694418045182, "Blood creatinine abnormal ": 4.260021302812305, "Blood creatinine increased ": 8.230139590679972, "Bone deformity ": 4.20988270138978, "Bone demineralisation ": 74.29079661197093, "Bone density abnormal ": 57.33276829701274, "Bone density decreased ": 78.92184879562389, "Bone disorder ": 28.906023333376645, "Bone fragmentation ": 14.614271483527272, "Bone infarction ": 9.526918499842992, "Bone loss ": 64.03061146942787, "Bone metabolism disorder ": 6.875897753192371, "CD4 lymphocytes abnormal ": 14.30317134192232, "CD4 lymphocytes decreased ": 2.9978228154580413, "Calcium deficiency ": 3.749160713369047, "Cervical radiculopathy ": 3.467042123751412, "Cervical spinal stenosis ": 6.869822920980888, "Cervical vertebral fracture ": 5.562828680428085, "Chronic kidney disease ": 54.30446761194408, "Chronic kidney disease-mineral and bone disorder ": 48.94111877355381, "Clavicle fracture ": 16.9479262962467, "Compression 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4.322916990169276, "Fractured coccyx ": 10.8046082759269, "Fractured sacrum ": 9.074323540278211, "Genotype drug resistance test positive ": 2.8460984090956205, "Glomerular filtration rate abnormal ": 29.376490636131688, "Glomerular filtration rate decreased ": 4.8327112381646975, "Glomerular filtration rate increased ": 9.139097611744242, "Glycosuria ": 4.516974126708405, "Hand fracture ": 37.6019804961547, "Hip arthroplasty ": 10.137294714304495, "Hip fracture ": 7.150697716045842, "Hip surgery ": 2.4156702687435168, "Humerus fracture ": 10.63627156988016, "Hydronephrosis ": 2.0739293236879965, "Hyperparathyroidism ": 3.728920468137089, "Hyperparathyroidism secondary ": 12.726096951404992, "Hypertensive nephropathy ": 5.81513219828528, "Immune reconstitution inflammatory syndrome ": 2.085008705322505, "Intervertebral disc degeneration ": 16.00146844249128, "Intervertebral disc protrusion ": 2.168589481816562, "Intervertebral disc space narrowing ": 2.8791322446840857, "Jaw fracture ": 16.89673923512782, "Kidney small ": 7.327498114953578, "Limb fracture ": 30.61004843188345, "Loose tooth ": 2.1690106094917314, "Loss of personal independence in daily activities ": 2.3981231852904603, "Lower limb fracture ": 8.79094575229899, "Lumbar spinal stenosis ": 3.825423780632272, "Lumbar vertebral fracture ": 4.74401153220382, "Medical diet ": 14.769176305851964, "Multiple fractures ": 63.59495811946002, "Nephrectomy ": 3.198458489711401, "Nephrogenic anaemia ": 13.785214180238956, "Nephrolithiasis ": 3.3988420190678585, "Nephropathy ": 41.3887994361458, "Osteoarthritis ": 7.662655291517863, "Osteochondrosis ": 2.5701721111532385, "Osteogenesis imperfecta ": 2.585485204882509, "Osteomalacia ": 34.368516648652104, "Osteonecrosis ": 53.32525997511447, "Osteopenia ": 68.31019063939806, "Osteoporosis ": 48.2989046874149, "Osteoporotic fracture ": 25.654815836290396, "Pain ": 4.198385354821227, "Partner stress ": 2.734755129734826, "Patella fracture ": 10.587732344437724, "Patellofemoral pain syndrome ": 3.1221547288735256, "Pathological fracture ": 6.539336186316638, "Pelvic fracture ": 2.069212464389205, "Periodontal disease ": 3.058779080546067, "Pituitary-dependent Cushing's syndrome ": 2.7535466194941174, "Poor dental condition ": 9.92006364782072, "Posterior tibial tendon dysfunction ": 56.94605046303012, "Pregnancy with implant contraceptive ": 5.340970659714591, "Protein total abnormal ": 43.5989040572801, "Protein total increased ": 18.3844909322867, "Protein urine present ": 5.3953293617237055, "Proteinuria ": 5.9216403271562585, "Pulpless tooth ": 6.9454398154350185, "Quality of life decreased ": 13.160117790790572, "Radius fracture ": 21.679412632250795, "Renal atrophy ": 7.678372007290936, "Renal cyst ": 8.599351473558642, "Renal failure ": 20.318526495366758, "Renal impairment ": 6.522784237835131, "Renal injury ": 99.81318656530578, "Renal mass ": 5.437195601084016, "Renal transplant ": 4.142595447806777, "Renal tubular acidosis ": 4.802415964175574, "Renal tubular disorder ": 2.699799105229941, "Renal tubular dysfunction ": 6.675385441387734, "Renal tubular injury ": 13.385763089139475, "Renal tubular necrosis ": 3.3588853086579697, "Rib fracture ": 14.367268478849308, "Scapula fracture ": 23.309734854504462, "Shoulder arthroplasty ": 5.263334162118969, "Shoulder fracture ": 10.35315155808041, "Sitting disability ": 6.293584189671739, "Skeletal injury ": 114.8498199553552, "Skull fracture ": 2.408687156980318, "Spinal column injury ": 5.472019407686605, "Spinal compression fracture ": 7.208886660711597, "Spinal deformity ": 2.991122738699659, "Spinal fracture ": 5.709313813255997, "Spinal fusion surgery ": 2.307573067065805, "Spinal osteoarthritis ": 10.124938645459425, "Spinal stenosis ": 5.517703497010627, "Spondylitic myelopathy ": 31.003153552017856, "Spondylolisthesis ": 12.804722585507765, "Spondylolysis ": 13.641233563602716, "Stress fracture ": 12.024331876018335, "T-lymphocyte count decreased ": 5.657631964314568, "Teeth brittle ": 36.19989430414055, "Thoracic vertebral fracture ": 6.744285537957572, "Tibia fracture ": 21.433211205973333, "Tooth disorder ": 2.7618408752834807, "Tooth erosion ": 2.060900128466028, "Tooth extraction ": 8.557413172010012, "Tooth fracture ": 35.97492952177401, "Tooth impacted ": 10.06724456053118, "Tooth injury ": 843.0683356298147, "Tooth loss ": 86.98250481022028, "Traumatic fracture ": 2.3314990671403426, "Ulna fracture ": 18.301690014399345, "Underweight ": 8.116249260535712, "Unemployment ": 12.338751234123718, "Upper limb fracture ": 8.624920736524158, "Vertebral foraminal stenosis ": 14.771258551862829, "Vertebral osteophyte ": 4.343362834592239, "Viral load increased ": 2.937051567944192, "Virologic failure ": 2.0640077732999016, "Vitamin D decreased ": 2.876135009724897, "Vitamin D deficiency ": 52.40866713315488, "Wrist fracture ": 25.625364501547597} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1180.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1180.json new file mode 100644 index 00000000000..ab7d92f8242 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1180.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 3.5334053952819207, "Agitation ": 2.888920676884368, "Alanine aminotransferase abnormal ": 29.440642694940514, "Aphasia ": 13.946453313172247, "Aspartate aminotransferase increased ": 2.367820508889373, "Aspergillus infection ": 5.149610333616589, "B-cell aplasia ": 105.01606126652784, "B-cell lymphoma ": 25.700012548907285, "Bacteraemia ": 8.802988200883284, "Bone marrow failure ": 12.491171229720694, "Bradykinesia ": 15.289778675334308, "Bradyphrenia ": 17.15757591743116, "Brain oedema ": 8.70466275827124, "Clostridium difficile colitis ": 2.965516752817785, "Clostridium difficile infection ": 3.146396404017156, "Coagulopathy ": 2.284966711588554, "Confusional state ": 3.431549087613782, "Cytokine release syndrome ": 1132.215433833366, "Cytokine storm ": 113.96681113744314, "Cytomegalovirus infection reactivation ": 8.17698841467584, "Cytopenia ": 31.33116623690948, "Death ": 3.5292376209164846, "Depressed level of consciousness ": 2.747902572659217, "Diffuse large B-cell lymphoma ": 88.44877055912738, "Diffuse large B-cell lymphoma recurrent ": 37.29693213465015, "Disease progression ": 15.335334935028651, "Disease recurrence ": 5.695378780197661, "Disorientation ": 4.217527845458372, "Disseminated intravascular coagulation ": 3.3469378820965554, "Dysgraphia ": 49.00119438871456, "Encephalopathy ": 27.64547330737424, "Febrile neutropenia ": 6.44990512549063, "Haemophagocytic lymphohistiocytosis ": 29.78905983703002, "Hyperbilirubinaemia ": 3.793739634463942, "Hypertransaminasaemia ": 4.145280065610461, "Hypervolaemia ": 4.527191962245125, "Hypoalbuminaemia ": 21.912588334117206, "Hypogammaglobulinaemia ": 78.53503916656763, "Hypotension ": 3.397055144219587, "Hypoxia ": 8.396987476281254, "Immune effector cell-associated neurotoxicity syndrome ": 2252.4733315214685, "Incontinence ": 13.276346641173468, "Infection ": 2.92690775161163, "Lymphoma ": 12.77224862846974, "Memory impairment ": 2.343798909178276, "Mental status changes ": 8.193608969219776, "Multiple organ dysfunction syndrome ": 3.287513838781345, "Myelodysplastic syndrome ": 5.69639157441125, "Nervous system disorder ": 3.036023505601178, "Neurological symptom ": 3.932976493530116, "Neurotoxicity ": 343.4460247622447, "Neutropenia ": 4.726416336561662, "Pancytopenia ": 7.294153515095287, "Pleural effusion ": 2.4143088169479467, "Primary mediastinal large B-cell lymphoma ": 376.71858990274416, "Sepsis ": 3.0186360400002594, "Septic shock ": 5.950482192849383, "Serum ferritin increased ": 9.292896250720664, "Status epilepticus ": 2.47426321594554, "Systemic candida ": 15.470756552538058, "Tachycardia ": 2.2369791658611637, "Tachypnoea ": 3.25688135546752, "Therapy non-responder ": 2.5553856275398177, "Therapy partial responder ": 3.696353065879283, "Thrombocytopenia ": 2.035956666188308, "Tremor ": 2.9958551438361463} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1181.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1181.json new file mode 100644 index 00000000000..a89aad965d3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1181.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 5.096166118004733, "Alanine aminotransferase increased ": 6.042228462807276, "Anaemia ": 3.998053285368551, "Aspartate aminotransferase increased ": 4.863140768882386, "Blood alkaline phosphatase increased ": 7.09801570466784, "Blood bilirubin increased ": 4.467904246632971, "Blood creatine phosphokinase increased ": 19.163283829621587, "Capillary leak syndrome ": 78.05570506736963, "Cardiac failure ": 5.4906114744960695, "Catheter site erythema ": 82.19907633765617, "Cholestasis ": 8.78889935741572, "Disease progression ": 5.430112799785632, "Extravasation ": 219.13372806767552, "Febrile neutropenia ": 11.031648660353635, "Gamma-glutamyltransferase increased ": 6.669493541020436, "Haematotoxicity ": 27.102429169140475, "Hepatic cytolysis ": 19.964846515916463, "Hepatic enzyme increased ": 3.4749654815084074, "Hepatic failure ": 11.40502088599487, "Hepatic function abnormal ": 3.702116887134036, "Hepatotoxicity ": 19.531439013723443, "Hypertransaminasaemia ": 26.536317994353084, "Infusion site extravasation ": 170.21029631779604, "Leukopenia ": 5.256302080622599, "Multiple organ dysfunction syndrome ": 8.030080488581554, "Myelosuppression ": 4.890360513337416, "Neutropenia ": 14.22905547140738, "Neutropenic sepsis ": 40.93582995344361, "Neutrophil count decreased ": 3.963931140250513, "Pancytopenia ": 21.793830302109644, "Platelet count decreased ": 2.8349447596269224, "Pleural effusion ": 3.156311965447801, "Pulmonary embolism ": 2.0523336845785307, "Renal failure ": 3.931701952138176, "Rhabdomyolysis ": 49.58194982393093, "Sarcoma ": 123.17448561593534, "Sepsis ": 5.464519096291464, "Septic shock ": 5.198717897605632, "Thrombocytopenia ": 8.658436094116635, "Transaminases increased ": 20.572968040246952} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1182.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1182.json new file mode 100644 index 00000000000..2d1c899c7b4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1182.json @@ -0,0 +1 @@ +{"Thrombocytopenia ": 33.6963348638808} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1183.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1183.json new file mode 100644 index 00000000000..c529c9b8104 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1183.json @@ -0,0 +1 @@ +{"Disease progression ": 66.12009232952163, "Pancytopenia ": 42.12177304765153} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1184.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1184.json new file mode 100644 index 00000000000..d3d1f91e690 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1184.json @@ -0,0 +1 @@ +{"Intentional overdose ": 17.66585940476954, "Somnolence ": 6.366280307194479, "Tachycardia ": 7.297925207129911} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1185.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1185.json new file mode 100644 index 00000000000..28e7b7bca89 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1185.json @@ -0,0 +1 @@ +{"Completed suicide ": 83.49165343645447, "Toxicity to various agents ": 16.427490773455173} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1186.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1186.json new file mode 100644 index 00000000000..e742a0cf95d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1186.json @@ -0,0 +1 @@ +{"Asthenia ": 2.1675024286621385, "Diarrhoea ": 7.946974230389584, "Hypertension ": 5.39447631711572, "Neuropathy peripheral ": 9.423157485279408, "Neutropenia ": 12.688046669023231, "Neutrophil count decreased ": 13.902036354182746, "Proteinuria ": 34.85095200530019, "Thrombocytopenia ": 4.171631462935892} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1187.json 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8.835778045538053} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1190.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1190.json new file mode 100644 index 00000000000..4061aa7e582 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1190.json @@ -0,0 +1 @@ +{"Hyponatraemia ": 71.49573461877132} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1191.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1191.json new file mode 100644 index 00000000000..d1986f02d63 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1191.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.6997288950118885, "Adverse drug reaction ": 9.046900481954678, "Blood pressure increased ": 4.591996010431943, "Carbohydrate antigen 125 increased ": 285.5785119182075, "Constipation ": 5.6273115538596725, "Drug hypersensitivity ": 3.091774643868139, "Dry mouth ": 3.2620418374035376, "Dyspepsia ": 2.361983253494369, "Flatulence ": 5.670689525681608, "Haemoglobin decreased ": 5.6470189749710045, "Heart rate increased ": 4.688671924695227, "Illness ": 3.566532500852188, "Insomnia ": 2.8234805089933075, "Neuropathy peripheral ": 9.58059667034042, "Platelet count decreased ": 6.030893997856028, "Product dose omission in error ": 37.735137892659885, "Product dose omission issue ": 5.875875550405029, "Sleep disorder ": 2.6855933521846715, "Taste disorder ": 4.73597570467942} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1192.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1192.json new file mode 100644 index 00000000000..f43557e92d4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1192.json @@ -0,0 +1 @@ +{"Acne ": 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2.0381982913901044} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1193.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1193.json new file mode 100644 index 00000000000..03bf393c07f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1193.json @@ -0,0 +1 @@ +{"Adverse event ": 21.46923532415132, "Alanine aminotransferase increased ": 2.894299571840142, "Alopecia ": 2.481650002487497, "Ascites ": 5.837390909391751, "Aspartate aminotransferase increased ": 2.0025941408951837, "Blood bilirubin increased ": 3.230507347985777, "Depression ": 2.4235263320194136, "Dyspepsia ": 2.0425352548633824, "Dysphagia ": 2.359828298224959, "Hepatic cirrhosis ": 12.134097510682, "Hepatitis C ": 53.639794945656256, "Hypertransaminasaemia ": 11.505857133645623, "Insomnia ": 2.221148345960796, "Irritability ": 2.3672451513448864, "Product dose omission issue ": 6.760180780468845, "Transaminases increased ": 4.710252917028419, "Treatment failure ": 10.099577573633452, "Virologic failure ": 84.34085865790985} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1194.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1194.json new file mode 100644 index 00000000000..66852593af0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1194.json @@ -0,0 +1 @@ +{"Leukopenia ": 55.47428453801862, "Lymphopenia ": 343.82570308638475, "Neutropenia ": 27.22585115951664} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1195.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1195.json new file mode 100644 index 00000000000..c35aaa98bf0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1195.json @@ -0,0 +1 @@ +{"Blood lactic acid increased 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1198.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1198.json new file mode 100644 index 00000000000..cfc8ede21e6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1198.json @@ -0,0 +1 @@ +{"Anaemia ": 45.80609921184413, "Weight decreased ": 3.842837775259624} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1199.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1199.json new file mode 100644 index 00000000000..92e0c1939e5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1199.json @@ -0,0 +1 @@ +{"Drug ineffective ": 5.025902228987543, "Neutropenia ": 14.512016842360689} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/12.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/12.json new file mode 100644 index 00000000000..a56ec0c9ffd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/12.json @@ -0,0 +1 @@ +{"Bone pain ": 22.1530615163487, "Chest pain ": 3.674712311667832, "Neutropenia ": 15.908291807085313, "Therapy non-responder ": 33.217418955752905} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/120.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/120.json new file mode 100644 index 00000000000..fbab3b5cde5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/120.json @@ -0,0 +1 @@ +{"Haematotoxicity ": 900.225238050385, "Mucosal inflammation ": 248.2440796808056, "Multiple organ dysfunction syndrome ": 40.39871300762043, "Neutropenia ": 35.42540171394921, "Pyrexia ": 4.059378692465007, "Sepsis ": 51.48045479911119} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1200.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1200.json new file mode 100644 index 00000000000..dabb35cce3b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1200.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 5.861718054897056, "Alopecia ": 4.760617450716126, "Aspartate aminotransferase increased ": 5.417595901406393, "Eczema ": 10.35389393301356, "Gamma-glutamyltransferase increased ": 6.332316417040714, "Liver function test increased ": 16.158964072406498, "Multiple sclerosis ": 20.702358230624483, "Multiple sclerosis relapse ": 147.53093478950782, "Psoriasis ": 5.849242037953012, "Rash ": 2.500259020969504, "Urinary tract infection ": 4.419242063856719} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1201.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1201.json new file mode 100644 index 00000000000..2aebb305209 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1201.json @@ -0,0 +1 @@ +{"Clostridium difficile infection ": 798.4585521068532, "Drug ineffective ": 12.315350415126836} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1202.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1202.json new file mode 100644 index 00000000000..9622b773946 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1202.json @@ -0,0 +1 @@ +{"Completed suicide ": 51.41570996496304} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1203.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1203.json new file mode 100644 index 00000000000..4a3abcb4469 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1203.json @@ -0,0 +1 @@ +{"Exposure during pregnancy ": 46.89507925655583} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1204.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1204.json new file mode 100644 index 00000000000..5804c946a73 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1204.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.132787931469786, "Disease progression ": 4.5333313600465255, "Hypercalcaemia ": 39.44529671253941, "Hypocalcaemia ": 65.58578364951654, "Malignant neoplasm progression ": 7.868406437144278, "Metastases to bone ": 29.374429379307216, "Osteonecrosis of jaw ": 390.7119213060007} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1205.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1205.json new file mode 100644 index 00000000000..5e23c7cd842 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1205.json @@ -0,0 +1 @@ +{"Diarrhoea ": 2.788207509449657, "Lactic acidosis ": 61.4950458281488} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1206.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1206.json new file mode 100644 index 00000000000..8f44a639b3e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1206.json @@ -0,0 +1 @@ +{"Abscess ": 13.327878876799396, "Actinomycosis ": 455.2063790686895, "Acute kidney injury ": 3.2780515268582646, "Anaemia ": 2.862494021140573, "Aortic arteriosclerosis ": 55.2295906269168, "Aortic valve incompetence ": 26.34132372946341, "Arteriosclerosis ": 9.835765219158038, "Arthritis ": 2.0453810811446984, "Arthropathy ": 2.430895632992411, "Atelectasis ": 23.739961690060543, "Blood alkaline phosphatase increased ": 2.9294284995589384, "Blood creatinine increased ": 5.489353047981829, "Blood urea increased ": 10.988333564731985, "Bone disorder ": 41.80690296883919, "Bone lesion ": 103.63858104400656, "Bone pain ": 3.57574804264202, "Bone sequestrum ": 1451.4647828344212, "Bronchitis ": 4.231971282776687, "Cardiac failure congestive ": 2.054579128034899, "Cardiomegaly ": 18.884744779447683, "Cataract ": 4.2491718357283785, "Cellulitis ": 2.6517937366580027, "Cholelithiasis ": 5.003313386098775, "Chronic obstructive pulmonary disease ": 4.592053406444897, "Circulatory collapse ": 3.399830281282492, "Compression fracture ": 42.66425174097731, "Deep vein thrombosis ": 2.0029373390952188, "Dehydration ": 2.3289602204786526, "Haematocrit decreased ": 6.303005249763632, "Haemoglobin decreased ": 2.360016145650666, "Hypocalcaemia ": 19.713913298984803, "Hypokalaemia ": 2.356209244741283, "Impaired healing ": 5.11357132893882, "Malignant neoplasm progression ": 5.594598733873204, "Metastases to bone ": 20.61406513089984, "Metastases to liver ": 5.033653834751213, "Osteomyelitis ": 35.10675871764828, "Osteonecrosis ": 5.591603834989503, "Osteonecrosis of jaw ": 194.4531119845519, "Pain in jaw ": 9.804681688608202, "Platelet count decreased ": 2.100403131220224, "Red blood cell count decreased ": 4.146037488744774, "Tooth disorder ": 10.949681459368056, "Tooth extraction ": 91.64366988596448} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1207.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1207.json new file mode 100644 index 00000000000..7ba362a546b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1207.json @@ -0,0 +1 @@ +{"Drug interaction ": 9.638167667220303, "Hypersensitivity ": 2.2341482219216244, "Migraine ": 4.0665620084698375, "Seizure ": 8.948579498804962, "Vertigo ": 3.995681524225828, "Weight decreased ": 4.140551471611718, "Weight increased ": 6.5412668695867495} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1208.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1208.json new file mode 100644 index 00000000000..ce8f99513e0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1208.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 10.15880150495769, "Altered state of consciousness ": 4.500602372188896, "Anuria ": 18.93129004190845, "Bipolar disorder ": 47.7760182561827, "Blood creatine phosphokinase increased ": 3.452511679802398, "Blood urea increased ": 10.683918867731062, "Bradycardia ": 2.557206636240675, "Depressed level of consciousness ": 5.605950268983202, "Drug eruption ": 7.800527925233679, "Drug ineffective ": 4.661092038611515, "Drug intolerance ": 5.296459878887359, "Drug 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2.055609582391482, "Treatment failure ": 5.101233045034793, "Tubulointerstitial nephritis ": 16.623826372446818, "Urinary tract infection ": 3.988565454538741, "Weight increased ": 4.469000600615219, "White blood cell count increased ": 6.168997813084316} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1209.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1209.json new file mode 100644 index 00000000000..d4b3cbe800a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1209.json @@ -0,0 +1 @@ +{"Abdominal hernia ": 5.164686893440604, "Abdominal mass ": 4.012595331183077, "Abnormal loss of weight ": 2.593827767860415, "Acoustic neuroma ": 11.877041876860147, "Acquired mixed hyperlipidaemia ": 489.9709026207715, "Actinic keratosis ": 25.115868048007226, "Acute left ventricular failure ": 7.199599984938528, "Acute respiratory failure ": 2.00413730896295, "Acute 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"Bronchial hyperreactivity ": 3.1221362777724835, "Bronchitis ": 3.839916759821718, "Bronchitis chronic ": 6.110821475577046, "Cardiac disorder ": 2.4051129467115966, "Cardiac failure congestive ": 2.059926702823945, "Cardiac murmur ": 3.321291667150521, "Cardiac operation ": 2.415432798526544, "Cardiac pacemaker insertion ": 2.698815180337641, "Carotid arteriosclerosis ": 4.153971721405801, "Carotid artery disease ": 7.161937981930075, "Carotid artery occlusion ": 2.3278746787088505, "Carotid artery stenosis ": 8.229210202647831, "Carotid bruit ": 19.786381317737995, "Carpal tunnel decompression ": 8.206074668850489, "Carpal tunnel syndrome ": 8.274418285922948, "Cataract ": 7.046807611290622, "Cataract cortical ": 97.67816847681476, "Cataract nuclear ": 182.8715189798205, "Cataract operation ": 7.683389338662602, "Catheterisation cardiac ": 3.487179841369404, "Cellulitis ": 5.23092019367588, "Cerebral atrophy ": 3.4912753068742, "Cerebral small vessel ischaemic disease ": 67.47869830337089, "Cerebrovascular disorder ": 2.623814105010817, "Cerumen impaction ": 73.72581199397733, "Cervical radiculopathy ": 33.08728414826788, "Cervical spinal stenosis ": 15.012093805560996, "Chalazion ": 8.409123794092395, "Cholecystectomy ": 6.500390445283776, "Chronic inflammatory demyelinating polyradiculoneuropathy ": 7.049010180928649, "Chronic left ventricular failure ": 42.45776242319851, "Chronic obstructive pulmonary disease ": 5.565360111693838, "Chronic respiratory failure ": 6.331923596071674, "Claustrophobia ": 7.873274343145658, "Colonoscopy ": 35.99695135219424, "Colorectal adenoma ": 11.036312597761317, "Conjunctivitis allergic ": 3.931144467832018, "Conjunctivitis viral ": 21.88456741933103, "Contraindication to vaccination ": 21.664203187001128, "Corneal abrasion ": 12.484862253777656, "Corneal dystrophy ": 18.032862491740755, "Corneal opacity ": 6.069480620509656, "Corneal scar ": 44.56044824106241, "Coronary arterial stent insertion ": 3.675918806280832, "Coronary artery disease ": 3.702522649773601, "Costochondritis ": 2.325925479556899, "Cranial nerve disorder ": 5.87469429796592, "Cystocele ": 12.482295013046157, "Deafness ": 9.557754320972135, "Deafness bilateral ": 3.2207353680896342, "Deafness neurosensory ": 24.907899836589124, "Deafness unilateral ": 3.98832658817158, "Depression ": 3.627693464314411, "Dermal cyst ": 5.70329922960105, "Dermatitis ": 3.626117179895468, "Dermatitis atopic ": 2.609811975511752, "Dermatitis contact ": 7.734630316258774, "Dermatochalasis ": 55.37455434208067, "Diabetes mellitus ": 2.335580625021749, "Diabetic foot ": 2.1623559715197254, "Diabetic nephropathy ": 8.178549837230154, "Diabetic neuropathy ": 12.945531658703144, "Diabetic retinopathy ": 4.281667516142378, "Diabetic vascular disorder ": 30.444960257871987, "Diastolic dysfunction ": 4.652107857374554, "Disseminated varicella zoster vaccine virus infection ": 99.54034013877184, "Diuretic therapy ": 81.48589891249225, "Diverticulum ": 3.8329047830558176, "Diverticulum intestinal ": 3.1507552693242835, "Dry age-related macular degeneration ": 28.504464586709105, "Dry eye ": 6.100251831387898, "Dupuytren's contracture ": 4.910147733224104, "Dyslipidaemia ": 4.855031760757992, "Ear disorder ": 3.2103347400128683, "Ear pain ": 2.3051840614357166, "Emphysema ": 3.4545367110704635, "Encephalitis ": 2.811486779645027, "Encephalitis herpes ": 11.0755512626431, "Endoscopy ": 18.06499122502921, "Epicondylitis ": 4.426158506678191, "Epiretinal membrane ": 31.427946747425445, "Escherichia urinary tract infection ": 3.45164344427893, "Essential hypertension ": 71.06891966554274, "Eustachian tube dysfunction ": 22.709674856824957, "Exposure keratitis ": 127.74748647142104, "Extra dose administered ": 8.200312703226981, "Eye discharge ": 2.14234490059549, "Eye disorder ": 2.5532981991579757, "Eye infection ": 4.799395420799756, "Eye injury ": 2.8774390464823547, "Eye operation ": 2.331425337200373, "Eyelid ptosis ": 3.340530579989222, "Facial pain ": 3.5606281674251994, "Fibrocystic breast disease ": 10.297957616739248, "Fibromyalgia ": 2.2916462378410563, "Foot deformity ": 2.3036316008558164, "Foot operation ": 2.377305263020258, "Foreign body sensation in eyes ": 2.1563545715424257, "Frustration tolerance decreased ": 2.817179626055943, "Fungal skin infection ": 4.506964963583756, "Gallbladder operation ": 4.415855434840808, "Gastrooesophageal reflux disease ": 7.78073378978634, "Generalised anxiety disorder ": 18.170285042452846, "Genital herpes ": 4.811531776866793, "Genital herpes simplex ": 18.867533534476784, "Genital herpes zoster ": 39.46231972736071, "Giant cell arteritis ": 6.616122537711889, "Glaucoma ": 6.032526246744823, "Glucose tolerance impaired ": 17.75243995811166, "Goitre ": 4.380409437500573, "Gout ": 6.056440480471248, "Grief reaction ": 14.152414596794053, "Guillain-Barre syndrome ": 2.992409264921013, "Haemangioma of skin ": 9.083401029576477, "Haemorrhoids ": 2.2175998117468003, "Hepatic cyst ": 2.336137971959278, "Hernia ": 3.438175435487462, "Hernia repair ": 6.873119302981594, "Herpes dermatitis ": 14.271290395599584, "Herpes ophthalmic ": 13.007494699000096, "Herpes simplex ": 8.116162279543603, "Herpes virus infection ": 3.3273371846989366, "Herpes zoster ": 50.55248663934648, "Herpes zoster cutaneous disseminated ": 20.23082701366594, "Herpes zoster disseminated ": 83.19416761622605, "Herpes zoster infection neurological ": 41.1470387436672, "Herpes zoster meningoencephalitis ": 12.96453523217852, "Herpes zoster oticus ": 66.95677680885454, "Herpes zoster reactivation ": 59.07217233105953, "Hiatus hernia ": 3.074170269806032, "Hip arthroplasty ": 4.230668839777007, "Hordeolum ": 2.509776644258744, "Hypercholesterolaemia ": 5.684071235337333, "Hyperkeratosis ": 3.8778762548414303, "Hyperlipidaemia ": 29.05772636951609, "Hypermetropia ": 22.84129668947689, "Hyperparathyroidism ": 3.629773562872243, "Hypertension ": 2.1217684623846047, 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2.570573485855684, "Iritis ": 8.01080610508938, "Iron deficiency anaemia ": 3.61618860687412, "Ischaemic stroke ": 2.3377378250285927, "Joint injury ": 3.4829098160259115, "Keratitis ": 4.112810337089968, "Knee arthroplasty ": 8.676798999757185, "Knee operation ": 6.680789086079987, "Kyphosis ": 4.545257189281386, "Labelled drug-drug interaction issue ": 17.81219378337435, "Labyrinthitis ": 3.050958584191286, "Lacrimation decreased ": 13.157699378137997, "Large intestine benign neoplasm ": 41.413996076460165, "Large intestine polyp ": 8.159074353469759, "Left ventricular hypertrophy ": 5.63642101762027, "Lichen planus ": 3.0324280435932334, "Ligament sprain ": 5.649413402354802, "Limb injury ": 3.270131234152873, "Limb operation ": 2.22364390440566, "Lipoma ": 4.351657130454828, "Lower urinary tract symptoms ": 16.17324292387107, "Lumbar radiculopathy ": 59.21880598284709, "Lumbar spinal stenosis ": 21.522236952455497, "Lumbosacral radiculopathy ": 23.404036088623457, "Lyme disease ": 2.6831974103452803, "Lymphocyte percentage decreased ": 4.5548006185633945, "Macular degeneration ": 2.084731392308088, "Macular hole ": 5.734687094075265, "Major depression ": 8.639625671818244, "Mammogram abnormal ": 18.358284377925024, "Meibomian gland dysfunction ": 32.0153541750301, "Melanocytic naevus ": 10.73653273248661, "Meniere's disease ": 4.372665369048065, "Meniscus injury ": 4.731643656075844, "Menopausal symptoms ": 5.313546838501924, "Menopause ": 7.221315517760544, "Metabolic surgery ": 5.5518264464461, "Migraine without aura ": 6.890266185386682, "Mitral valve incompetence ": 2.440923727544879, "Mitral valve prolapse ": 3.701553899849742, "Muscle relaxant therapy ": 218.53919008947216, "Muscle strain ": 6.321185694276393, "Myelitis transverse ": 5.733914332188312, "Myelopathy ": 7.274613438673619, "Myofascial pain syndrome ": 8.38120436529354, "Myopia ": 4.930646479734463, "Nasal oedema ": 2.6097134084408986, "Nasal septum deviation ": 11.238121331867946, "Neck injury ": 2.794561064494443, "Neck surgery ": 7.642698585987916, "Necrotising retinitis ": 24.194802752771867, "Neoplasm skin ": 5.879093831947936, "Nephrolithiasis ": 2.32892741875493, "Nerve compression ": 2.610670728636749, "Nerve injury ": 11.338229505166307, "Nervous system disorder ": 2.7175111887767254, "Neuralgia ": 7.063246701746626, "Neuritis ": 5.400003832179604, "Neurodermatitis ": 3.1705791747851166, "Neurogenic bladder ": 3.1323021500467965, "Neuropathy peripheral ": 2.6458730394863523, "Neurotrophic keratopathy ": 106.38086844845338, "Nicotine dependence ": 2.352641027342492, "Nocturia ": 2.3678534303632417, "Normocytic anaemia ": 2.497668997278105, "Obesity ": 15.277143640395344, "Obstructive sleep apnoea syndrome ": 21.249320749623745, "Occipital neuralgia ": 8.34938428033506, "Occupational exposure to product ": 3.232285161238911, "Ocular hypertension ": 4.581015030890859, "Onychomycosis ": 6.148349457915384, "Open angle glaucoma ": 18.17196269105628, "Ophthalmic herpes simplex ": 47.09985954922732, "Ophthalmic herpes zoster ": 102.7002753113882, "Optic ischaemic neuropathy ": 2.229958495541152, "Optic nerve injury ": 5.5729332034412495, "Oral herpes ": 3.810454711025185, "Organic erectile dysfunction ": 19.441982514860808, "Osteoarthritis ": 8.998382647059312, "Osteopenia ": 2.185507406751505, "Otitis externa ": 12.10889728270801, "Otitis media ": 3.287192828625292, "Otitis media acute ": 7.778919171669348, "Overweight ": 14.152103584257732, "Paranasal sinus discomfort ": 2.9091104776320784, "Peptic ulcer ": 2.7326662008311007, "Peripheral arterial occlusive disease ": 3.865087411301512, "Peripheral vascular disorder ": 3.314793763181421, "Peripheral venous disease ": 3.5864718923126166, "Peroneal nerve palsy ": 2.9671968753821045, "Plantar fasciitis ": 3.979053448573323, "Polymyalgia rheumatica ": 6.885032098115992, "Polyneuropathy ": 2.063368375042501, "Poor quality sleep ": 2.739491859186051, "Post herpetic neuralgia ": 329.024380833753, "Post 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8.802447006537854, "Rotator cuff repair ": 5.462180156962764, "Rotator cuff syndrome ": 7.642729290842138, "Scab ": 3.5522107429754106, "Scar ": 17.04068537786901, "Sciatica ": 6.052735617914976, "Scoliosis ": 4.410059229193188, "Seasonal allergy ": 8.261526700599104, "Seborrhoeic dermatitis ": 14.317317930714903, "Seborrhoeic keratosis ": 60.672912563595176, "Secondary transmission ": 80.56599852933752, "Shoulder arthroplasty ": 7.058523283133602, "Shoulder operation ": 11.695241199809098, "Sialoadenitis ": 6.969878833291585, "Sinus congestion ": 2.2967643221686287, "Sinus disorder ": 3.938583846328531, "Skin abrasion ": 2.559447183834304, "Skin cancer ": 5.461614999824607, "Skin infection ": 2.3122884353416806, "Skin lesion ": 2.1200552263884025, "Skin papilloma ": 2.1999281008216918, "Sleep apnoea syndrome ": 5.143442676131692, "Sleep disorder ": 2.257511875863736, "Snoring ": 3.690172928231879, "Spinal disorder ": 3.530377752061156, "Spinal fusion surgery ": 8.847521952088963, "Spinal operation ": 7.114843973902861, "Spinal osteoarthritis ": 14.013917365510688, "Spinal stenosis ": 5.8646668845195125, "Spondylitis ": 2.6045687497375662, "Spondylolisthesis ": 7.257123795243408, "Stent placement ": 2.2969317012684654, "Stress ": 2.822684838816258, "Stress urinary incontinence ": 9.679072103604822, "Synovial cyst ": 6.313474926924271, "Temporomandibular pain and dysfunction syndrome ": 10.11146093499598, "Thyroid disorder ": 4.533358829503437, "Thyroid mass ": 6.5886007643980005, "Thyroidectomy ": 4.378751058950307, "Tinea pedis ": 4.6041639707257564, "Tobacco abuse ": 15.364687387318444, "Tonsillectomy ": 10.46303975015456, "Tricuspid valve incompetence ": 2.148413063730897, "Trigeminal neuralgia ": 6.66856368378855, "Trigger finger ": 10.66807378701282, "Type 2 diabetes mellitus ": 6.19144527342971, "Type IIa hyperlipidaemia ": 47.19605635139588, "Type V hyperlipidaemia ": 56.273148011420645, "Ulcerative keratitis ": 2.4644074591980454, "Umbilical hernia ": 4.25179769911184, "Upper respiratory tract infection ": 3.064717013662638, "Upper-airway cough syndrome ": 3.990006224925632, "Urge incontinence ": 11.866572033876968, "Urinary tract disorder ": 2.742348726621436, "VIth nerve paralysis ": 4.506964963583756, "Vaccination error ": 11.508274203990172, "Vaccination failure ": 9.14507482156081, "Vaccination site cellulitis ": 8.733367800009974, "Vaccination site rash ": 2.068398244515403, "Vaccination site vesicles ": 4.524481850795033, "Vaginal infection ": 2.0808275578654354, "Varicella ": 5.577965828526666, "Varicella virus test positive ": 57.61123800070495, "Varicella zoster pneumonia ": 73.02133441692403, "Varicella zoster virus infection ": 11.32545490064734, "Varicose vein ": 2.320067612114117, "Vertebral foraminal stenosis ": 12.821176609450546, "Vertigo positional ": 3.678494900597949, "Vestibular neuronitis ": 2.4643476771286768, "Vitamin B complex deficiency ": 11.323003200017338, "Vitamin B12 deficiency ": 10.579272743312004, "Vitamin D decreased ": 3.741944628578685, "Vitamin D deficiency ": 10.43365847233664, "Vitreous degeneration ": 68.902158181046, "Vitreous detachment ": 17.27819071894264, "Vitreous floaters ": 3.2667187511970104, "Weight abnormal ": 9.44750254504612, "Weight fluctuation ": 2.6375087600136995} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/121.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/121.json new file mode 100644 index 00000000000..17f2c6ee259 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/121.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 2.5492370835868856, "Affective disorder ": 5.059052774068652, "Alanine aminotransferase abnormal ": 30.99561154379193, "Amyotrophy ": 19.565235765802377, "Anaemia ": 2.005749835707711, "Anosmia ": 7.543077166591415, "Anti-cyclic citrullinated peptide antibody ": 23.573254037434868, "Anti-cyclic citrullinated 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58.830644713481, "Chondrocalcinosis pyrophosphate ": 34.86290439608444, "Chronic obstructive pulmonary disease ": 10.079534371712144, "Chronic sinusitis ": 52.37197552871875, "Chronic spontaneous urticaria ": 19.082042532117885, "Colitis ": 13.987987656743774, "Colitis ulcerative ": 14.686878300851731, "Condition aggravated ": 2.5644233008085164, "Constipation ": 3.455575285974829, "Cough ": 2.6925439288912902, "Crystal arthropathy ": 382.83432380324575, "Cushing's syndrome ": 7.750653315880079, "Disease recurrence ": 2.1374249897447597, "Drug hypersensitivity ": 3.273125281812124, "Drug ineffective ": 2.6843357731491, "Dust allergy ": 33.820685612502025, "Dyspepsia ": 6.497273792486839, "Dyspnoea ": 2.751217065736715, "Dyspnoea exertional ": 14.882810343737576, "Dyspraxia ": 12.6253792159631, "Ear pruritus ": 14.316476362783142, "Eczema ": 16.34384639890735, "Eosinophil count abnormal ": 53.68464120784988, "Eosinophil count increased ": 6.95119126830032, "Eosinophilic bronchitis ": 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": 4.295055557915918, "Intraocular pressure increased ": 6.406823546302142, "Lacrimation increased ": 2.397789322153405, "Loss of personal independence in daily activities ": 11.658809588355831, "Lung opacity ": 15.652962664824289, "Macular degeneration ": 100.631583862083, "Malignant mediastinal neoplasm ": 321.4682757996754, "Middle insomnia ": 3.040514724276893, "Motor developmental delay ": 16.659412148175193, "Movement disorder ": 2.196162140511912, "NSAID exacerbated respiratory disease ": 2578.1190087691425, "Nasal congestion ": 19.63620574961391, "Nasal crusting ": 27.4970156152809, "Nasal discomfort ": 13.284000866359689, "Nasal dryness ": 10.621506202579573, "Nasal obstruction ": 135.62439723234328, "Nasal oedema ": 13.542034530464951, "Nasal polyps ": 124.64345505077404, "Nasal septum perforation ": 33.312940071794905, "Nasal ulcer ": 23.839769141132308, "Obsessive-compulsive disorder ": 4.975782922883751, "Obstructive airways disorder ": 36.83179941451178, "Ocular 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4.037465408132624, "Respiratory tract infection ": 16.89078865799146, "Respiratory tract inflammation ": 27.946816646585976, "Restrictive pulmonary disease ": 20.30760107716089, "Reversible airways obstruction ": 94.17905426529416, "Rhinalgia ": 25.91224553379479, "Rhinitis ": 4.128318354387429, "Rhinitis allergic ": 20.09440589859913, "Rhinorrhoea ": 11.883770938545128, "Sarcoidosis ": 8.412933791849955, "Seasonal allergy ": 9.67220499431581, "Secretion discharge ": 63.076199352665874, "Sensory processing disorder ": 57.05568389839017, "Sinus congestion ": 9.961862135316215, "Sinus headache ": 2.794226439797592, "Sinusitis ": 9.980935133095418, "Sleep apnoea syndrome ": 17.295993368830857, "Sleep disorder due to a general medical condition ": 46.24329138886964, "Sneezing ": 6.813494220316039, "Social avoidant behaviour ": 3.2169048698569287, "Sputum discoloured ": 30.49434085564466, "Stent placement ": 11.597411926819522, "Stereotypy ": 12.715941350773315, "Taste disorder ": 2.9794160195307478, "Therapeutic product effect incomplete ": 28.0658591091407, "Therapy interrupted ": 2.307831217583779, "Throat clearing ": 205.87447492713576, "Throat irritation ": 3.264730080379355, "Thyroid cancer ": 2.527365830530212, "Thyroid disorder ": 4.258936277735723, "Thyroid neoplasm ": 13.731338799572873, "Thyroidectomy ": 12.103747226502794, "Tooth development disorder ": 70.71829513793976, "Total lung capacity decreased ": 12.10264314939236, "Total lung capacity increased ": 223.62474719659772, "Tracheomalacia ": 46.57433352542154, "Upper respiratory tract infection ": 3.0503914026203462, "Upper-airway cough syndrome ": 9.224396721177278, "Vaginal discharge ": 45.67737894435127, "Vaginal flatulence ": 103.09892772177292, "Vital capacity decreased ": 33.708023149884795, "Weight decreased ": 2.7536061956871776, "Wheezing ": 16.320894925417466} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1210.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1210.json new file mode 100644 index 00000000000..a4fd6b3ad20 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1210.json @@ -0,0 +1 @@ +{"Application site erythema ": 30.13932401420249, "Application site pain ": 12.679312445768767, "Application site reaction ": 39.556561252101694, "Application site scab ": 461.3967579998862, "Blister ": 3.5442575108053176, "Decreased appetite ": 2.670832543963208, "Erythema ": 4.986901281586055, "Erythema multiforme ": 9.560866635513914, "Inflammation ": 4.791144196106012, "Influenza like illness ": 4.690176277945901, "Oropharyngeal pain ": 2.079486191570606, "Scab ": 135.80833631003176, "Skin burning sensation ": 9.35178344231789, "Skin reaction ": 19.03068767252705, "Wound ": 7.660046100007945} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1211.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1211.json new file mode 100644 index 00000000000..2c05f95aa0d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1211.json @@ -0,0 +1 @@ +{"Diarrhoea ": 4.664401319104965} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1212.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1212.json new file mode 100644 index 00000000000..009960b5f4f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1212.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.536820778793655, "Abdominal pain upper ": 8.253573309960352, "Angina pectoris ": 15.01791663778948, "Angioedema ": 4.551821124708186, "Coronary artery thrombosis ": 160.65552500694767, "Drug ineffective ": 3.1038392149901366, "Drug interaction ": 2.22771476481896, "Dyspepsia ": 8.012185363188555, "Epistaxis ": 15.19584620684367, "Erythema ": 4.047587861710797, "Product substitution issue ": 27.06103239303645, "Pruritus ": 7.78500757438934, "Rash ": 2.74612598197987, "Urticaria ": 9.606667415344369, "Vascular stent thrombosis ": 138.0150982923855} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1213.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1213.json new file mode 100644 index 00000000000..728327cb18e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1213.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 4.974195543518177, "Abscess limb ": 8.907174373435073, "Aggression ": 7.693713985210725, "Agitation ": 16.09520139701912, "Akathisia ": 29.23638263451846, "Altered state of consciousness ": 6.098538538996962, "Amnesia ": 2.9605379745798617, "Antipsychotic drug level increased ": 11.793153247741134, "Anxiety ": 2.55641610942508, "Ataxia ": 22.57490787699817, "Balance disorder ": 5.496747060021855, "Blood pressure decreased ": 3.847174014593083, "Blood pressure increased ": 3.8597944659133, "Bradyphrenia ": 5.382589566057559, "Cognitive disorder ": 3.628932009166916, "Coma ": 5.448804033078474, "Confusional state ": 14.5999685816965, "Consciousness fluctuating ": 23.833402679072265, "Coordination abnormal ": 5.333590560366172, "Delirium ": 15.587739702654378, "Delusion ": 3.6048305583936657, "Depressed level of consciousness ": 6.974873881044728, "Disorientation ": 29.82390288543815, "Disturbance in attention ": 3.193905399840759, "Dizziness ": 2.9243051032934058, "Drug level decreased ": 4.112976623075581, "Drug level increased ": 4.2712946673072505, "Dysarthria ": 58.70617919143494, "Dyskinesia ": 7.768752914180816, "Dysstasia ": 4.683869315360095, "Dystonia ": 4.480892946158898, "Extrapyramidal disorder ": 24.678070147681662, "Feeling drunk ": 23.81473364229841, "Gait disturbance ": 4.805018332407942, "Hallucination, auditory ": 3.010679029354051, "Hallucination, visual ": 2.544636836470833, "Heart rate increased ": 5.069417699783813, "Hypersomnia ": 6.416259329163188, "Hypertension ": 2.539246086510817, "Hypotension ": 2.4756405231120846, "Hypotonia ": 3.0019890175146755, "Immediate post-injection reaction ": 113.16399785885174, "Incoherent ": 14.516592500646311, "Incorrect route of product administration ": 2.897577996630229, "Injection related reaction ": 30.009545814606085, "Injection site abscess ": 105.09789913813586, "Injection site extravasation ": 9.81296537995781, "Injection site haemorrhage ": 8.814872713036596, "Injection site mass ": 3.757335327248045, "Loss of consciousness ": 2.677706478363381, "Miosis ": 7.962094257083629, "Muscle rigidity ": 5.275722377631711, "Muscle twitching ": 2.5134405385365186, "Neuroleptic malignant syndrome ": 4.160085951465657, "Overdose ": 2.8951672394409647, "Pallor ": 4.008174543568239, "Post procedural complication ": 88.53570773576514, "Post-injection delirium sedation syndrome ": 3968.163149506781, "Prescribed overdose ": 25.019653221165527, "Product administered at inappropriate site ": 7.380180241670926, "Psychomotor hyperactivity ": 18.42425375766652, "Psychotic disorder ": 6.155587087679568, "Restless legs syndrome ": 5.691738086625223, "Restlessness ": 13.442609828665727, "Salivary hypersecretion ": 4.118029418083848, "Schizophrenia ": 21.36373084332392, "Sedation ": 106.64327216150753, "Sedation complication ": 16.4995846831076, "Sinus tachycardia ": 4.280952019551647, "Somnolence ": 13.286736649537692, "Sopor ": 9.28064573873982, "Speech disorder ": 11.555275411917076, "Stupor ": 10.97224510541739, "Tachycardia ": 4.088564252873231, "Tardive dyskinesia ": 5.6349484121202185, "Unresponsive to stimuli ": 7.946171076445163, "Urinary incontinence ": 2.6666043959039936, "Vertigo ": 2.57662937836009, "Weight increased ": 3.4178019852734374} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1214.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1214.json new file mode 100644 index 00000000000..4aa77360115 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1214.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 3.566399861795604, "Abnormal weight gain ": 8.664802590360368, "Abulia ": 6.440529739071105, "Accidental overdose ": 2.174367119340546, "Acidosis ": 2.216967025830745, "Acute psychosis ": 5.174574349681914, "Affect lability ": 2.343477978976052, "Aggression ": 4.120879718859056, "Agitation ": 4.668850229763304, "Agitation neonatal ": 8.28936972127874, "Akathisia ": 17.46367824396271, "Akinesia ": 2.704758957505391, "Alanine aminotransferase increased ": 4.010272484062591, "Alcohol abuse ": 2.897917832979334, "Alcohol poisoning ": 4.09410588870549, "Alcohol withdrawal syndrome ": 8.77376466562783, "Alcoholism ": 6.73902509706444, "Altered state of consciousness ": 3.4411979518512434, "Amylase increased ": 2.560621699453914, "Anger ": 2.424903205000438, "Angle closure glaucoma ": 2.476663455096601, "Anticholinergic syndrome ": 4.0707804444432965, "Antidepressant drug level increased ": 16.890541440676117, "Antipsychotic drug level increased ": 4.8880740623079, "Apallic syndrome ": 11.130878533341958, "Apathy ": 3.716186082816292, "Apgar score low ": 3.910623778748796, "Appetite disorder ": 2.127353234777491, "Aspartate aminotransferase increased ": 4.308038550707559, "Aspiration ": 3.030996202754517, "Ataxia ": 2.008740988940944, "Atrioventricular block second degree ": 2.965062409514157, "Autonomic nervous system imbalance ": 2.2989511702555423, "Behaviour disorder ": 2.513334593176341, "Binge eating ": 5.963426213338195, "Bipolar I disorder ": 8.433214361337289, "Bipolar disorder ": 7.550605157566669, "Bladder dilatation ": 4.166996749933885, "Blood alkaline phosphatase increased ": 3.062838422163804, "Blood chloride decreased ": 2.3126415676723826, "Blood cholesterol abnormal ": 18.721964369663095, "Blood cholesterol increased ": 7.148705009319468, "Blood creatine phosphokinase MB increased ": 2.370075140237085, "Blood creatine phosphokinase increased ": 9.383103472940888, "Blood glucose increased ": 2.584120456938054, "Blood lactate dehydrogenase increased ": 2.387142234485301, "Blood prolactin increased ": 21.685241915982584, "Blood sodium decreased ": 2.450780305457465, "Blood triglycerides increased ": 33.84626014211938, "Body mass index increased ": 3.419602997968908, "Bradykinesia ": 2.7018454460739987, "Bradyphrenia ": 2.6534028205758537, "Brain death ": 2.70301258780795, "Brain injury ": 2.427785694793206, "Breast enlargement ": 3.420498989317903, "Bruxism ": 2.483291708957956, "Bundle branch block right ": 2.09361369094556, "Cardiac hypertrophy ": 3.188004540090515, "Catatonia ": 14.01385406055225, "Cerebral atrophy ": 2.798446420336941, "Cerebrovascular disorder ": 3.912715065415471, "Cholelithiasis ": 2.2814739803491992, "Choreoathetosis ": 4.767504971440186, "Clonic convulsion ": 3.15310569170505, "Clonus ": 2.074164085782093, "Cogwheel rigidity ": 17.53869953576088, "Coma ": 5.732816550082031, "Communication disorder ": 2.3856103067994647, "Completed suicide ": 2.7594506840860022, "Craniocerebral injury ": 2.2033645574720486, "Decreased interest ": 2.7069383970640644, "Decubitus ulcer ": 3.724063753471079, "Delirium ": 5.092557345386584, "Delusion ": 8.217355103437207, "Depressed level of consciousness ": 2.901233265934018, "Depressive symptom ": 2.4368056075384312, "Diabetes insipidus ": 3.4326556602616947, "Diabetes mellitus ": 27.945370773614137, "Diabetes mellitus inadequate control ": 2.2571293419371847, "Diabetic coma ": 49.46844437744479, "Diabetic complication ": 3.612306794849199, "Diabetic foot ": 2.969149638576205, "Diabetic hyperglycaemic coma ": 6.794034007900975, "Diabetic hyperosmolar coma ": 75.06022336659977, "Diabetic ketoacidosis ": 9.708810155299544, "Diabetic ketosis ": 15.38794202383344, "Diabetic nephropathy ": 10.300323979748224, "Diabetic neuropathy ": 19.57954386470773, "Diabetic retinopathy ": 3.491502538606862, "Diet refusal ": 5.387113282423931, "Disinhibition ": 2.931223054429402, "Disorientation ": 2.227140069878215, "Drooling ": 10.59189724131937, "Drug interaction ": 2.130968536104548, "Drug level increased ": 2.7521604163721265, "Drug use disorder ": 2.339296383948818, "Drug withdrawal syndrome neonatal ": 2.6115860446176558, "Dysarthria ": 2.852999275591684, "Dyskinesia ": 6.596708984899679, "Dyslalia ": 2.4759309683808337, "Dyslipidaemia ": 16.1814252035681, "Dysphemia ": 3.370030340456351, "Dystonia ": 13.317688292937348, "Electrocardiogram QT prolonged ": 4.594499426067631, "Electrocardiogram abnormal ": 2.3059323158623317, "Electroencephalogram abnormal ": 5.525788423732841, "Emotional disorder ": 2.3817556488502776, "Emotional poverty ": 7.611317837003887, "Endotracheal intubation ": 3.821457620439124, "Enuresis ": 3.4983951516448752, "Erectile dysfunction ": 3.8361869473422616, "Essential hypertension ": 2.396428503018617, "Extrapyramidal disorder ": 17.223853266768288, "Eye movement disorder ": 2.5836841658192555, "Faecaloma ": 2.451650984361995, "Fear ": 2.039911755356885, "Flat affect ": 8.35110303422757, "Food craving ": 7.179228382130544, "Galactorrhoea ": 18.076007985334044, "Gamma-glutamyltransferase increased ": 4.241921089613284, "Gastrointestinal oedema ": 3.0268398602898263, "Gaze palsy ": 2.1670657168287693, "Generalised anxiety disorder ": 3.138172305162715, "Generalised tonic-clonic seizure ": 5.9862343331461885, "Gestational diabetes ": 10.068843221680137, "Glucose tolerance impaired ": 15.224548656496314, "Glucose urine present ": 4.557271525088346, "Glutamate dehydrogenase increased ": 22.79795703353525, "Glycosuria ": 11.715524148597604, "Granulocytopenia ": 2.1178301208937627, "Gynaecomastia ": 9.252248870444353, "Hallucination ": 2.159350643355357, "Hallucination, auditory ": 6.832288572019277, "Hallucinations, mixed ": 2.657407961420685, "Hepatic enzyme abnormal ": 2.7636323268437946, "Hepatic enzyme increased ": 2.8548741222927885, "Hepatic steatosis ": 9.316903275164472, "High density lipoprotein decreased ": 6.47134708074725, "Homicidal ideation ": 3.069224600526086, "Hospitalisation ": 2.049682089854247, "Hostility ": 5.845001153648316, "Hunger ": 3.0862484602135645, "Hypercapnia ": 4.593318771609615, "Hypercholesterolaemia ": 8.911636697864235, "Hyperglycaemia ": 8.739558623725001, "Hyperglycaemic hyperosmolar nonketotic syndrome ": 17.029439724273008, "Hyperkinesia ": 4.524166563001368, "Hyperlipidaemia ": 16.807143223473794, "Hypernatraemia ": 3.954822764883928, "Hyperosmolar state ": 25.421020597272967, "Hyperphagia ": 23.176904236376306, "Hyperprolactinaemia ": 14.304159997413674, "Hypersomnia ": 3.0484420696777907, "Hyperthermia ": 3.820736865382058, "Hyperthermia malignant ": 3.5785457210063467, "Hypertonia ": 3.079811398520228, "Hypertriglyceridaemia ": 10.606737216144456, "Hypogonadism ": 3.4909112197528485, "Hypomania ": 4.824270892076987, "Hyponatraemia ": 2.8557417266785845, "Hypothermia ": 4.182162221453252, "Hypotonia neonatal ": 8.021537254859577, "Hypoventilation ": 2.681014305037764, "Hypoxic-ischaemic encephalopathy ": 3.288391837224776, "Ileus ": 2.752931906856737, "Ileus paralytic ": 4.308669342203076, "Illusion ": 2.438440532483894, "Impaired fasting glucose ": 9.472145022956637, "Inappropriate affect ": 3.658862029781966, "Inappropriate antidiuretic hormone secretion ": 4.491925364503508, "Incoherent ": 2.902030991375747, "Incontinence ": 4.261679012117064, "Increased appetite ": 18.71879465352872, "Infantile apnoea ": 3.038217069702191, "Insulin resistance ": 3.889250128705401, "Insulin-requiring type 2 diabetes mellitus ": 19.914807531028707, "Intentional overdose ": 7.941652174465774, "Intentional self-injury ": 3.0418204352096465, "Intestinal dilatation ": 4.208933860377842, "Iron deficiency anaemia ": 2.342445791629729, "Ketoacidosis ": 5.664235703338711, "Ketonuria ": 6.1369292381943765, "Ketosis ": 3.2793548960857444, "Left ventricular hypertrophy ": 5.813500893793271, "Leukocytosis ": 2.9899729898801004, "Leukopenia ": 2.025476611164348, "Libido decreased ": 2.4291218071755067, "Libido disorder ": 5.011274901838199, "Lipase increased ": 2.1135296053248007, "Lipids abnormal ": 8.691064027313393, "Lipids increased ": 12.961412966144104, "Logorrhoea ": 3.7534733630240473, "Long QT syndrome ": 2.101405788258744, "Low density lipoprotein increased ": 5.355905437674048, "Major depression ": 3.316289176196924, "Mania ": 9.842347318232331, "Mental disorder ": 3.655220285092621, "Mental impairment ": 2.1677128202902334, "Mental status changes ": 2.4106202658282565, "Metabolic disorder ": 10.252153690012651, "Metabolic syndrome ": 45.67785530482576, "Microalbuminuria ": 7.341479726927162, "Micturition disorder ": 2.2019781419053555, "Miosis ": 6.142805859887483, "Mixed liver injury ": 2.1296587495833457, "Muscle rigidity ": 11.520855826122212, "Mutism ": 7.974915111242755, "Myoclonus ": 2.511097029462208, "Myoglobin blood increased ": 4.32845365190316, "Neonatal respiratory distress ": 2.714470591450501, "Neonatal respiratory distress syndrome ": 4.484552222197485, "Nephrogenic diabetes insipidus ": 3.201542183250081, "Neuroleptic malignant syndrome ": 43.50682076135289, "Neutrophil count increased ": 2.435738739663856, "Nuchal rigidity ": 2.0007899326893392, "Obesity ": 15.727893569764973, "Obsessive thoughts ": 9.106373952905454, "Obsessive-compulsive disorder ": 4.350587210559445, "Obstructive sleep apnoea syndrome ": 3.2927071125975385, "Oculogyric crisis ": 8.815602300199465, "Oedema peripheral ": 2.180975493732439, "Onychomycosis ": 3.487010150680951, "Opisthotonus ": 4.568121020654727, "Orthostatic hypotension ": 2.26877459989974, "Overdose ": 4.436000958492175, "Overweight ": 4.157780558618842, "Pancreatic disorder ": 2.9054042186608093, "Pancreatic pseudocyst ": 4.596008826205094, "Pancreatitis ": 5.188768890673827, "Pancreatitis acute ": 2.774000244627797, "Pancreatitis chronic ": 4.508069701474809, "Pancreatitis necrotising ": 2.225011387348092, "Pancreatitis relapsing ": 4.3143328506515095, "Paranoia ": 4.850032534517471, "Parkinson's disease ": 2.54374095667948, "Parkinsonian gait ": 7.115324045415322, "Parkinsonism ": 15.681670210029065, "Peripheral venous disease ": 2.631285683951333, "Persecutory delusion ": 8.148108422900913, "Personality disorder ": 3.182268678831566, "Physical assault ": 3.459840721567651, "Pituitary tumour benign ": 3.432428826828059, "Pleurothotonus ": 13.29450809415053, "Pneumonia aspiration ": 5.425633561563041, "Polydipsia ": 25.09898153193511, "Polyuria ": 6.273739608579961, "Poor feeding infant ": 2.818547464676096, "Poor peripheral circulation ": 2.746893796203969, "Postresuscitation encephalopathy ": 58.74823363078491, "Posture abnormal ": 3.7193035578131823, "Potentiating drug interaction ": 3.118373461953376, "Prescribed overdose ": 43.68725474392463, "Priapism ": 12.411333828450598, "Prothrombin time shortened ": 2.8762673410982744, "Protrusion tongue ": 7.695042052797245, "Psychiatric decompensation ": 8.906618439569613, "Psychiatric symptom ": 6.873586095912122, "Psychomotor hyperactivity ": 3.7529999391417967, "Psychomotor retardation ": 5.2300472652238135, "Psychotic disorder ": 8.378843721672734, "Pulmonary embolism ": 2.1530327472684765, "Pulmonary infarction ": 2.2766425526113023, "Reduced facial expression ": 6.65388253231199, "Respiratory depression ": 3.803655832250898, "Respiratory disorder neonatal ": 4.234480986408012, "Respiratory rate decreased ": 2.668268690365525, "Restless legs syndrome ": 2.030360964883424, "Restlessness ": 3.2539282386160946, "Rhabdomyolysis ": 6.191222633861633, "Salivary hypersecretion ": 4.97840556391158, "Schizoaffective disorder ": 8.878148154916273, "Schizophrenia ": 17.08547428508869, "Schizophreniform disorder ": 10.424357905123252, "Sedation ": 7.796374294609893, "Sedation complication ": 4.940327508195969, "Seizure ": 2.3219443366647696, "Selective eating disorder ": 3.9440043436217342, "Self esteem decreased ": 7.115552077342087, "Self-destructive behaviour ": 4.659190558155582, "Self-injurious ideation ": 4.0223846981473885, "Serotonin syndrome ": 3.1322252258774474, "Sexual dysfunction ": 3.001530121166997, "Sinus tachycardia ": 3.3499115780926965, "Skin striae ": 4.268365028069802, "Sleep apnoea syndrome ": 3.5518991829703337, "Slow response to stimuli ": 4.107898254638778, "Sluggishness ": 2.448737819521622, "Social avoidant behaviour ": 4.470849860454311, "Soliloquy ": 7.375252268434184, "Somnambulism ": 2.535021429605959, "Somnolence ": 2.9963627612934185, "Somnolence neonatal ": 13.438557631669282, "Sopor ": 5.251701376504839, "Speech disorder ": 2.3416074504669715, "Staring ": 2.5069869789393464, "Stupor ": 4.414903719105964, "Sudden cardiac death ": 2.0408116117964887, "Sudden death ": 7.7719381651965245, "Suicidal behaviour ": 3.0942742959344445, "Suicidal ideation ": 3.47952479444643, "Suicide attempt ": 8.289200141312431, "Supraventricular extrasystoles ": 2.0136786817885395, "Tachyphrenia ": 2.5554383542128964, "Talipes ": 5.520231839178042, "Tardive dyskinesia ": 23.68293687485168, "Tension ": 2.702980224401572, "Thinking abnormal ": 4.172988788802751, "Thirst ": 2.762738917279277, "Thrombocytosis ": 2.285253523483035, "Tinea pedis ": 6.813225132136809, "Torticollis ": 4.791621878891849, "Toxicity to various agents ": 2.044255622616792, "Transaminases increased ": 2.405450244904582, "Trismus ": 2.063182590581448, "Type 1 diabetes mellitus ": 14.301828932237015, "Type 2 diabetes mellitus ": 34.115576957815925, "Urinary hesitation ": 10.658317809607908, "Urinary incontinence ": 3.379143310864157, "Urinary retention ": 2.6311103210662243, "Vascular dementia ": 7.412748895653999, "Water intoxication ": 22.635089173349705, "Weight increased ": 19.36424138424285, "White blood cell count increased ": 2.9695551534584075, "Withdrawal syndrome ": 2.3421312800579845, "Wrong patient received product ": 2.4635423448112053} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1215.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1215.json new file mode 100644 index 00000000000..9293477d72a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1215.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.921495966485069, "Cardiac failure ": 8.675111561641678, "Constipation ": 3.130077438763096, "Drug interaction ": 7.829372144369054, "Hypokalaemia ": 31.003792064069334, "Hyponatraemia ": 7.082231516235132, "Prostate cancer ": 19.69964984498989, "Rhabdomyolysis ": 11.56432057170765} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1216.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1216.json new file mode 100644 index 00000000000..b96d4ac6e1c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/1216.json @@ -0,0 +1 @@ +{"5-hydroxyindolacetic acid increased ": 14.313118104890432, "Abdominal rebound tenderness ": 2.395793498914625, "Abdominal tenderness ": 2.0651347866368277, "Abdominal wall anomaly ": 3.5626190555644883, "Abdominal wall haematoma ": 4.09094865253149, "Abnormal behaviour ": 2.1795503744548177, "Abnormal dreams ": 2.080384359713867, "Abnormal labour ": 4.269330168075982, "Abnormal palmar/plantar creases ": 3.9327400336564944, "Abnormal sleep-related event ": 2.236525450824806, "Abortion ": 2.3734057252690675, "Abortion incomplete ": 2.6575345329485165, "Abortion induced incomplete ": 65.16459095163641, "Abortion threatened ": 2.439933410514347, "Abulia ": 2.649708048519545, "Accelerated idioventricular rhythm ": 4.02283837449332, "Accessory cardiac pathway ": 2.2142953271576955, "Accidental device ingestion ": 8.254122559732778, "Accidental exposure to product ": 2.7179768189468825, "Accidental exposure to product by child ": 5.137167934321396, "Accidental exposure to product packaging ": 2.23656444563837, "Accidental overdose ": 4.627073048447862, "Accidental poisoning ": 3.902382049098631, "Accommodation disorder ": 3.049082258947944, "Acid base balance abnormal ": 2.486041568829552, "Acid-base balance disorder mixed ": 2.387804269380746, "Acidosis ": 2.8382245636667927, "Acquired oesophageal web ": 4.355173022300543, "Acquired pigmented retinopathy ": 6.297862414159445, "Acromegaly ": 4.949096273395504, "Activation syndrome ": 6.294233900142147, "Acute chest syndrome ": 2.660559239224512, "Acute generalised exanthematous pustulosis ": 6.349263987112983, "Acute hepatic failure ": 2.3629281803631894, "Acute kidney injury ": 2.171205905176986, "Acute myopia ": 7.560962273187651, "Acute phosphate nephropathy ": 2.1983590768470163, "Acute promyelocytic leukaemia ": 2.0273906677297657, "Adactyly ": 3.524007618038884, "Adams-Stokes syndrome ": 8.553946467711636, "Adenoidal hypertrophy ": 2.5360437193186063, "Adenoidectomy ": 2.3318466652000325, "Adenoiditis ": 2.0464318866351654, "Adjustment disorder with mixed disturbance of emotion and conduct ": 2.848173647013041, "Administration site discolouration ": 2.140036938623944, "Administration site extravasation ": 10.12488604992442, "Administration site irritation ": 7.533176267607137, "Administration site phlebitis ": 3.77657001277882, "Adrenal suppression ": 2.2281594077974782, "Adrenergic syndrome ": 2.8576095853763683, "Adulterated product ": 2.0638454372262287, "Aggression ": 2.6931713507479467, "Agitation ": 2.778574409854176, "Agitation neonatal ": 3.78355831096998, "Agitation postoperative ": 2.5460556445726743, "Agonal death struggle ": 2.1487608395327937, "Agonal rhythm ": 2.2450342229325893, "Agoraphobia ": 2.004823590841542, "Agranulocytosis ": 4.927088453389699, "Air embolism ": 3.175990198234768, "Airway complication of anaesthesia ": 2.9603906551004995, "Akinesia ": 2.399516099169364, "Albumin urine ": 2.387804269380746, "Alcohol abuse ": 2.790836913623908, "Alcohol interaction ": 3.836258269526734, "Alcohol intolerance ": 2.379010938841997, "Alcohol poisoning ": 3.4895729379752813, "Alcohol use ": 2.1867888567417912, "Aldolase increased ": 3.448287030836279, "Alice in wonderland syndrome ": 2.0495228807388, "Alkalosis ": 2.743087324668022, "Alkalosis hypokalaemic ": 2.936222849208289, "Allergic reaction to excipient ": 3.3892999561922634, "Allergic stomatitis ": 3.442779540174401, "Allergy test negative ": 3.9689408540697295, "Allergy test positive ": 9.463109291441148, "Altered state of consciousness ": 2.9394888581026146, "Amblyopia ": 2.44932772245501, "Ameloblastoma ": 4.492837504195562, "Ammonia abnormal ": 2.508763467269691, "Ammonia increased ": 2.3577383602278457, "Amniotic band syndrome ": 2.2843330867299185, "Amniotic cavity disorder ": 4.300975156186353, "Amniotic fluid index abnormal ": 3.442779540174401, "Amniotic fluid volume decreased ": 2.1268714758691285, "Amniotic infection syndrome of Blane ": 2.5907254632306738, "Anaemia megaloblastic ": 2.966863723380408, "Anaesthesia oral ": 2.147345400553251, "Anaesthetic complication ": 8.11981345920038, "Anal atresia ": 2.899146497746764, "Anal incontinence ": 2.018061518334978, "Anal sphincter atony ": 2.2651680013742945, "Analgesic drug level increased ": 6.628258560056476, "Anaphylactic reaction ": 2.5056977790544943, "Anaphylactic shock ": 6.62077176035986, "Anaphylactoid reaction ": 5.107694725197075, "Anaphylactoid shock ": 5.730523357847515, "Anaphylactoid syndrome of pregnancy ": 2.7785219446407257, "Androgen deficiency ": 4.114099390788256, "Androgens abnormal ": 3.792326896754684, "Anger ": 2.37083254902094, "Angioedema ": 3.72060064163402, "Angiogram cerebral abnormal ": 2.119843710264686, "Angiotensin converting enzyme inhibitor foetopathy ": 12.43575419658052, "Angle closure glaucoma ": 7.209278183284273, "Anhidrosis ": 2.434915845771003, "Anion gap increased ": 2.167810359253016, "Anisocoria ": 2.114220728310066, "Anomalous pulmonary venous connection ": 4.819314099548674, "Anomaly of external ear congenital ": 4.347186733757916, "Anorgasmia ": 4.817993371418747, "Antasthmatic drug level above therapeutic ": 10.123542394551846, "Anterior chamber fibrin ": 5.177702854182607, "Anterior chamber inflammation ": 2.3000034235670075, "Anterior chamber pigmentation ": 6.249107449882757, "Anti factor VIII antibody positive ": 2.126420140360335, "Anti-erythropoietin antibody ": 2.8918101261397577, "Anti-erythropoietin antibody negative ": 2.0206059268522774, "Anti-erythropoietin antibody positive ": 2.472424226495301, "Anti-neutrophil cytoplasmic antibody positive vasculitis ": 2.4171275984934173, "Antibiotic associated colitis ": 4.627060647228294, "Antibiotic level above therapeutic ": 9.647693326596746, "Antibiotic level below therapeutic ": 2.738922347820625, "Anticholinergic syndrome ": 2.6037678651474696, "Anticoagulant-related nephropathy ": 13.257198417882725, "Anticoagulation drug level above therapeutic ": 5.7675993332376985, "Anticoagulation drug level below therapeutic ": 3.442512862192141, "Anticonvulsant drug level abnormal ": 3.884878719463113, "Anticonvulsant drug level above therapeutic ": 4.267365141095341, "Anticonvulsant drug level below therapeutic ": 4.168703922756898, "Anticonvulsant drug level decreased ": 6.537895630009107, "Anticonvulsant drug level increased ": 5.135149256780477, "Antidepressant discontinuation syndrome ": 3.636371078044172, "Antidepressant drug level above therapeutic ": 3.967075970378113, "Antidepressant drug level below therapeutic ": 4.802594096429057, "Antidepressant drug level increased ": 5.497939411714516, "Antidiuretic hormone abnormality ": 2.882650336471254, "Antipsychotic drug level above therapeutic ": 6.304581907039694, "Antipsychotic drug level decreased ": 3.6736587314690303, "Antipsychotic drug level increased ": 6.679057747235033, "Antisocial behaviour ": 4.741994668750362, "Anuria ": 2.6178249325926988, "Aorta hypoplasia ": 3.037725845126247, "Aortic valve atresia ": 2.2450342229325893, "Aortic valve incompetence ": 2.37342960392887, "Aortic wall hypertrophy ": 2.739337169947462, "Aortitis ": 2.393703955661359, "Apgar score low ": 2.59331698936654, "Aplasia cutis congenita ": 8.80848717857811, "Apnoea ": 2.998305437336556, "Appendix cancer ": 5.228685282958513, "Application site abscess ": 2.037812422706561, "Application site acne ": 8.45167466525154, "Application site alopecia ": 3.791598180341608, "Application site burn ": 11.906851381874386, "Application site dermatitis ": 8.637843294500454, "Application site discharge ": 3.2487421000399466, "Application site discolouration ": 10.273378247491229, "Application site discomfort ": 7.208495727880573, "Application site dryness ": 41.06112461163088, "Application site eczema ": 7.192783404900978, "Application site erosion ": 7.26020539786171, "Application site erythema ": 3.1756403525679224, "Application site exfoliation ": 16.49450891866841, "Application site extravasation ": 11.135564435826042, "Application site folliculitis ": 4.010584589699205, "Application site haemorrhage ": 2.011579604917944, "Application site hypersensitivity ": 8.363043486911334, "Application site infection ": 3.304367878880804, "Application site inflammation ": 6.472640969371964, "Application site irritation ": 15.773994281436265, "Application site laceration ": 4.617604539187664, "Application site mass ": 2.7785219446407257, "Application site necrosis ": 4.554081806157254, "Application site odour ": 2.562402753033977, "Application site oedema ": 2.1124970914036787, "Application site papules ": 11.386139095903053, "Application site paraesthesia ": 9.833986126933397, "Application site photosensitivity reaction ": 2.2142953271576955, "Application site plaque ": 6.966216456354185, "Application site pruritus ": 8.857872411016452, "Application site pustules ": 4.261048660632532, "Application site rash ": 13.550628420921498, "Application site scab ": 2.8748535685179606, "Application site scar ": 13.602521812653652, "Application site ulcer ": 2.373810070128011, "Application site urticaria ": 12.755959937088909, "Application site vesicles ": 7.226662435139376, "Application site warmth ": 3.661475534210249, "Application site wound ": 4.109071196305052, "Aqueous fibrin ": 8.782520890325227, "Arachnodactyly ": 17.88498050344945, "Areflexia ": 2.1124531043519053, "Arnold-Chiari malformation ": 4.2896695402129, "Arrested labour ": 3.657729150466252, "Arterial insufficiency ": 2.1614517302000533, "Arterial restenosis ": 2.0528597347076776, "Arterial therapeutic procedure ": 2.0344411705489893, "Arteriospasm coronary ": 4.164066145162414, "Artificial crown procedure ": 2.039414910660589, "Asphyxia ": 3.394039828224976, "Assisted suicide ": 4.007036161400551, "Asterixis ": 3.28877564799773, "Asthmatic crisis ": 2.775888565712766, "Astigmatism ": 2.3834058851159496, "Ataxia ": 2.9230026521847443, "Atelectasis neonatal ": 3.8062365289207896, "Atheroembolism ": 2.208597383915884, "Athetosis ": 2.90035005239272, "Atrial conduction time prolongation ": 3.787364818909382, "Atrial hypertrophy ": 2.59950973928883, "Atrial septal defect ": 6.294432837684384, "Atrioventricular block ": 3.1220676030718284, "Atrioventricular block complete ": 3.4066641739005794, "Atrioventricular block first degree ": 3.3095953342670037, "Atrioventricular block second degree ": 2.451064112069192, "Atrioventricular dissociation ": 4.321368662114901, "Attention deficit hyperactivity disorder ": 4.559624596490248, "Autism spectrum disorder ": 8.856395948699529, "Azoospermia ": 4.27009467894008, "BRASH syndrome ": 2.5855824849966824, "Ballismus ": 2.3710324922897565, "Barrett's oesophagus ": 2.624166962657097, "Bartter's syndrome ": 6.106621335564846, "Base excess decreased ": 2.0933226683496997, "Base excess negative ": 2.5044046076704296, "Behaviour disorder ": 2.802126672761681, "Belligerence ": 2.0895536841468973, "Benign breast neoplasm ": 2.023146762353026, "Benign congenital hypotonia ": 5.198964971256344, "Benzodiazepine drug level increased ": 2.8246314187502346, "Bereavement ": 3.5148518229747605, "Bezoar ": 5.630591657227035, "Bicuspid aortic valve ": 8.263762588330993, "Bilirubinuria ": 2.2306810060740507, "Biopsy brain abnormal ": 9.224438259435836, "Biopsy breast ": 3.133680745964011, "Biopsy breast abnormal ": 11.077732316375805, "Biopsy colon abnormal ": 7.989991806006669, "Biopsy endometrium ": 4.1423793880704975, "Biopsy endometrium abnormal ": 2.7324561440655404, "Biopsy mucosa abnormal ": 3.0938723142390154, "Biopsy prostate ": 2.119843710264686, "Biopsy skin ": 2.779548869789919, "Biopsy skin abnormal ": 3.191864984008677, "Bipolar II disorder ": 2.9785366220926184, "Bipolar disorder ": 2.095435750385965, "Birth trauma ": 2.4815607600334006, "Bite ": 2.101633699983286, "Bladder cancer ": 9.444506687852456, "Bladder cancer stage II ": 2.739337169947462, "Bladder cancer stage III ": 2.5322569562112758, "Bladder cancer stage IV ": 2.4172669215511355, "Bladder dilatation ": 2.4644238263318696, "Bladder necrosis ": 9.151157299211915, "Bladder perforation ": 2.1222868188317268, "Blister rupture ": 2.046410553472152, "Blood 1,25-dihydroxycholecalciferol increased ": 2.158702033383775, "Blood 25-hydroxycholecalciferol increased ": 3.77657001277882, "Blood acid phosphatase increased ": 2.158702033383775, "Blood alcohol increased ": 3.5145677090731966, "Blood aldosterone increased ": 2.771171487222005, "Blood alkaline phosphatase increased ": 2.1058511218659026, "Blood aluminium increased ": 2.415129997857277, "Blood antidiuretic hormone decreased ": 2.387804269380746, "Blood antidiuretic hormone increased ": 2.831712131471681, "Blood bicarbonate decreased ": 2.0747068772987305, "Blood catecholamines increased ": 2.3523687945817944, "Blood cholinesterase decreased ": 3.106548277458922, "Blood cholinesterase increased ": 2.0954861709124013, "Blood chromogranin A increased ": 2.467786338083004, "Blood creatine phosphokinase ": 2.569455383556475, "Blood creatine phosphokinase increased ": 2.801613084082044, "Blood follicle stimulating hormone decreased ": 4.060989426796331, "Blood glucose false positive ": 7.408067933199498, "Blood growth hormone abnormal ": 4.422873492092894, "Blood growth hormone decreased ": 2.1110273354908933, "Blood growth hormone increased ": 4.254257869355732, "Blood lactic acid decreased ": 2.1497644818720323, "Blood luteinising hormone decreased ": 3.3811543937641435, "Blood mercury abnormal ": 8.826875229204319, "Blood oestrogen decreased ": 3.087517880022931, "Blood oestrogen increased ": 3.71263744014569, "Blood osmolarity decreased ": 3.5759889551906507, "Blood pressure decreased ": 2.328870092474373, "Blood pressure immeasurable ": 4.970459086487663, "Blood pressure inadequately controlled ": 3.7565980554356257, "Blood pressure orthostatic ": 2.992924724076415, "Blood prolactin increased ": 2.560482093641748, "Blood sodium decreased ": 2.038708358154325, "Blood sodium increased ": 2.1254556562260185, "Blood testosterone abnormal ": 2.7371621301886218, "Blood testosterone decreased ": 3.791160273071851, "Blood testosterone free decreased ": 3.4119142571515, "Blood testosterone increased ": 3.5997300350910018, "Blood urea increased ": 2.4067656008320184, "Bloody peritoneal effluent ": 6.8031563798956105, "Blunted affect ": 2.9558649782108204, "Body dysmorphic disorder ": 2.187165700215114, "Body height abnormal ": 2.05052867485809, "Body height decreased ": 2.3283573946524942, "Bone development abnormal ": 2.194682658719877, "Bone hyperpigmentation ": 12.348584906471904, "Bone marrow granuloma ": 5.879276102958377, "Brachial artery entrapment syndrome ": 4.000509736211133, "Brachycephaly ": 2.3725271003843598, "Brachydactyly ": 4.121242872845213, "Bradyarrhythmia ": 4.531337811583909, "Bradycardia ": 4.139522565604644, "Bradycardia foetal ": 2.6375230386540083, "Bradycardia neonatal ": 4.860418217932575, "Bradyphrenia ": 2.202819665104296, "Bradypnoea ": 7.390258809427916, "Brain injury ": 2.141691015596323, "Brain neoplasm malignant ": 3.425980426871486, "Breast calcifications ": 4.254321323894745, "Breast cancer ": 5.389194160530513, "Breast cancer female ": 3.612261894267164, "Breast cancer in situ ": 2.5201459396265244, "Breast cancer male ": 5.793712599498985, "Breast cancer metastatic ": 2.017743264265305, "Breast conserving surgery ": 3.145446526419118, "Breast discolouration ": 2.0174289351687524, "Breast feeding ": 2.509729990345664, "Breast fibrosis ": 2.079574660946283, "Breast hyperplasia ": 2.9400792309141184, "Breast malformation ": 2.8888362465479496, "Breast necrosis ": 5.083191106119852, "Breast reconstruction ": 2.80330718380949, "Breath alcohol test positive ": 8.782520890325227, "Breathing-related sleep disorder ": 2.1222868188317268, "Brief resolved unexplained event ": 2.0210695270957983, "Bromoderma ": 2.119843710264686, "Bronchial oedema ": 2.216280710420783, "Bronchomalacia ": 2.4815607600334006, "Bronchospasm ": 4.0409257328201145, "Bronchospasm paradoxical ": 7.23983070600359, "Bronchostenosis ": 3.3430720110221044, "Brugada syndrome ": 5.941825469695847, "Bruxism ": 2.700617782461273, "Bundle branch block ": 3.6321815932817008, "Bundle branch block right ": 2.385101126991965, "Burkholderia cepacia complex infection ": 2.34264995267084, "Burn oesophageal ": 4.645521309575196, "Burn oral cavity ": 3.643316454604004, "Burning sensation mucosal ": 2.8583683741825903, "Burns first degree ": 2.3454861914388463, "CSWS syndrome ": 4.1423793880704975, "Calciphylaxis ": 6.153934836026213, "Camptodactyly congenital ": 9.338023666888736, "Cannabinoid hyperemesis syndrome ": 3.774620949352752, "Carbon monoxide poisoning ": 2.412726658986069, "Carcinogenicity ": 16.412066977322873, "Cardiac arrest ": 2.655410469420524, "Cardiac arrest neonatal ": 4.153486078936919, "Cardiac massage ": 5.6671013587265735, "Cardiac murmur ": 2.594658844746046, "Cardiac pacemaker removal ": 2.2796882444559303, "Cardiac steatosis ": 2.0443614718434326, "Cardiac valve sclerosis ": 2.936222849208289, "Cardio-respiratory arrest ": 3.237164246953241, "Cardio-respiratory arrest neonatal ": 7.461888341814831, "Cardio-respiratory distress ": 2.03937860268986, "Cardioactive drug level above therapeutic ": 5.896547399339858, "Cardioactive drug level decreased ": 16.298584399143117, "Cardioactive drug level increased ": 16.37503001983234, "Carnitine decreased ": 2.1384046678205544, "Carnitine deficiency ": 4.198178255655119, "Carotid bruit ": 2.002485545933019, "Cataract congenital ": 2.942808161658988, "Catecholamines urine increased ": 2.693428309169082, "Catheter site discharge ": 2.026050891556175, "Catheter site erythema ": 2.0934306015453608, "Catheter site extravasation ": 3.52619349075127, "Catheter site urticaria ": 2.158702033383775, "Catheter site warmth ": 2.844207717923794, "Cauda equina syndrome ": 2.452575989619478, "Central auditory processing disorder ": 2.792889305099717, "Central nervous system stimulation ": 2.7985964375096817, "Central venous catheter removal ": 2.3694819820917625, "Central venous pressure decreased ": 2.4603171588385395, "Cerebellar ataxia ": 2.802600716165156, "Cerebellar atrophy ": 5.39611190431455, "Cerebellar hypoplasia ": 2.1366854047680577, "Cerebellar syndrome ": 2.525140640427933, "Cerebral atrophy ": 2.077087126163156, "Cerebral haemorrhage neonatal ": 2.5913256838914767, "Cerebral palsy ": 3.2265559738765006, "Cerebral vasoconstriction ": 2.2614637581272605, "Cerebral ventricle dilatation ": 2.7804684864385405, "Cervix carcinoma ": 2.261405827013813, "Cervix erythema ": 2.2142953271576955, "Chemical burn ": 7.515696281640654, "Chemical burn of oral cavity ": 4.143453142560489, "Chemical burn of respiratory tract ": 6.389045994236043, "Chemical burn of skin ": 5.5697481350599, "Chemical burns of eye ": 4.64777118174146, "Chemical cystitis ": 4.362431881502759, "Chemical phlebitis ": 8.0694678103627, "Chemical poisoning ": 2.670761264030718, "Chemical submission ": 2.411107289406896, "Cheyne-Stokes respiration ": 3.2576093592163944, "Chloasma ": 2.6900865223538863, "Choanal atresia ": 11.146063429893132, "Choking ": 3.126424088601889, "Choking sensation ": 3.0760840808994314, "Cholecystitis chronic ": 2.6672259111164243, "Cholestasis ": 2.4045497871051054, "Cholestatic liver injury ": 2.729866538516206, "Cholinergic syndrome ": 7.848200124263555, "Chordee ": 3.952252586488466, "Chorea ": 2.784908498041033, "Choreoathetosis ": 4.159022771896933, "Choroidal detachment ": 2.314194629978571, "Choroidal effusion ": 4.766080694878947, "Choroidal haemorrhage ": 4.496029359065561, "Chromaturia ": 2.1664074045570194, "Chronic hepatitis ": 2.4014421886678017, "Chronic obstructive pulmonary disease ": 2.026162680032986, "Chronotropic incompetence ": 3.0331553627838432, "Ciliary body disorder ": 3.4827677595506565, "Circulatory collapse ": 2.7545207384561903, "Circulatory failure neonatal ": 5.896547399339858, "Circumoral oedema ": 2.3716620455582684, "Circumstance or information capable of leading to device use error ": 2.060661229853793, "Circumstance or information capable of leading to medication error ": 2.5577816871447627, "Cleft lip ": 5.703858760757484, "Cleft lip and palate ": 3.878848062167914, "Cleft palate ": 5.674994930699225, "Cleft uvula ": 9.669067686204542, "Clinodactyly ": 5.316568274859348, "Clonic convulsion ": 2.655065787714786, "Clonus ": 2.27001975433668, "Clostridium colitis ": 2.798541905095965, "Clostridium difficile colitis ": 2.883645983708645, "Clostridium test positive ": 4.911122106780358, "Coagulation disorder neonatal ": 4.843626274582155, "Coagulation factor VII level decreased ": 2.4593523396094774, "Coagulation factor X level decreased ": 2.4950645103913405, "Coagulation factor decreased ": 2.9922010652665, "Coagulation test abnormal ": 2.113757246688267, "Coagulation time prolonged ": 4.0760177509932, "Coarctation of the aorta ": 7.639110905941137, "Coating in mouth ": 2.1632652325959785, "Cogwheel rigidity ": 2.2647010133458605, "Coloboma ": 2.142297341711985, "Colon cancer stage III ": 2.2246305539333093, "Colonic haematoma ": 2.4699264535838386, "Colonoscopy abnormal ": 3.5070305741311985, "Colony stimulating factor therapy ": 6.569142317722045, "Colorectal cancer ": 38.24214475571569, "Colorectal cancer stage I ": 5.992219891988702, "Colorectal cancer stage II ": 8.713709740761487, "Colorectal cancer stage III ": 4.483532431141876, "Colorectal cancer stage IV ": 2.449885637549513, "Colour vision tests abnormal ": 2.0732840918983566, "Coma ": 3.829866379483963, "Coma scale abnormal ": 2.909522303514924, "Communication disorder ": 2.6773233778093104, "Compartment syndrome ": 2.374626704888929, "Compensatory sweating ": 2.4172669215511355, "Completed suicide ": 5.35933710347481, "Complication associated with device ": 2.072931298625923, "Complication of delivery ": 2.260133068938337, "Complication of device insertion ": 3.839552982777063, "Complication of device removal ": 2.5460556445726743, "Compulsions ": 2.883764207588273, "Compulsive lip biting ": 2.848173647013041, "Conduction disorder ": 3.3687532136732954, "Congenital absence of bile ducts ": 2.259521014279036, "Congenital anomaly ": 3.2704689230368134, "Congenital anomaly in offspring ": 4.186724206320195, "Congenital aortic anomaly ": 2.1436111746495685, "Congenital aortic atresia ": 6.340477532119922, "Congenital aortic stenosis ": 12.130823781918492, "Congenital aortic valve incompetence ": 6.779355604401743, "Congenital aortic valve stenosis ": 11.966320698973249, "Congenital brain damage ": 4.893452046139301, "Congenital cardiovascular anomaly ": 13.091129553352667, "Congenital central nervous system anomaly ": 3.823610935757082, "Congenital cerebellar agenesis ": 4.843626274582155, "Congenital cerebral cyst ": 3.257312499748678, "Congenital coronary artery malformation ": 3.0519610348856903, "Congenital cyst ": 3.9817214600888367, "Congenital cystic kidney disease ": 2.7765584584197787, "Congenital diaphragmatic hernia ": 2.211141489254409, "Congenital eye disorder ": 5.214905144521248, "Congenital eyelid malformation ": 3.3592250169510494, "Congenital facial diplegia ": 6.718693413790624, "Congenital flat feet ": 6.142822436292995, "Congenital foot malformation ": 6.074003366358169, "Congenital genital malformation ": 2.263628304330927, "Congenital genital malformation male ": 3.018048574023795, "Congenital genitourinary abnormality ": 5.8435418733158135, "Congenital hand malformation ": 10.220279849209668, "Congenital hearing disorder ": 2.091528472676385, "Congenital heart valve disorder ": 6.915373319994121, "Congenital hydrocephalus ": 2.842235623081669, "Congenital hydronephrosis ": 2.1532386717524585, "Congenital hypothyroidism ": 5.924204865755229, "Congenital inguinal hernia ": 4.745736607642976, "Congenital jaw malformation ": 4.960764579439824, "Congenital knee deformity ": 2.951985109345318, "Congenital laryngeal stridor ": 2.119843710264686, "Congenital megacolon ": 2.7893707053248438, "Congenital megaureter ": 4.855175014559221, "Congenital mitral valve incompetence ": 4.577231279559243, "Congenital mitral valve stenosis ": 4.362431881502759, "Congenital multiplex arthrogryposis ": 3.076441908714847, "Congenital musculoskeletal disorder ": 3.078906456131421, "Congenital musculoskeletal disorder of limbs ": 7.184964465072198, "Congenital musculoskeletal disorder of skull ": 5.490266935379341, "Congenital musculoskeletal disorder of spine ": 3.161596924363436, "Congenital nail disorder ": 6.665797604505982, "Congenital neurological disorder ": 7.161141226200562, "Congenital nose malformation ": 8.97628505553988, "Congenital nystagmus ": 9.529860179479076, "Congenital oesophageal anomaly ": 2.848173647013041, "Congenital oral malformation ": 6.423967744863229, "Congenital pulmonary artery anomaly ": 10.133268100153286, "Congenital pulmonary hypertension ": 7.597558212164849, "Congenital pulmonary valve atresia ": 6.858535438694921, "Congenital pulmonary valve disorder ": 3.87893833691815, "Congenital renal disorder ": 3.720001388026715, "Congenital scoliosis ": 10.342615192874046, "Congenital skin dimples ": 2.226066968827946, "Congenital spinal cord anomaly ": 3.178702039398656, "Congenital syphilis ": 3.178702039398656, "Congenital tongue anomaly ": 3.5716248259132075, "Congenital torticollis ": 4.986923166446594, "Congenital tricuspid valve atresia ": 7.815999491952704, "Congenital tricuspid valve incompetence ": 2.3242317539059485, "Congenital urethral anomaly ": 2.946876774685152, "Congenital uterine anomaly ": 2.3778832419943305, "Congenital visual acuity reduced ": 7.580088704520082, "Conjunctival bleb ": 3.363071307471851, "Conjunctival cyst ": 2.5322569562112758, "Conjunctival deposit ": 3.615082672656949, "Conjunctival discolouration ": 2.635913811003926, "Conjunctival erosion ": 3.01474544380596, "Conjunctival filtering bleb leak ": 21.41468065131837, "Conjunctival hyperaemia ": 3.261581592645924, "Conjunctival oedema ": 3.5577112047649333, "Conjunctival ulcer ": 2.8166190633714923, "Consciousness fluctuating ": 2.6895067915123465, "Contact lens intolerance ": 5.872848245864311, "Contraindicated product prescribed ": 3.4772974339163, "Contraindication to medical treatment ": 3.5446371750639747, "Contrast media reaction ": 5.8427672306832825, "Contrast media toxicity ": 2.182707492679382, "Convulsions local ": 5.902802252869302, "Coombs direct test positive ": 2.1019569977481214, "Coprolalia ": 2.59950973928883, "Cord blood transplant therapy ": 3.018048574023795, "Cornea verticillata ": 2.23656444563837, "Corneal abrasion ": 2.1927608750352383, "Corneal degeneration ": 2.3242317539059485, "Corneal deposits ": 6.317827000882044, "Corneal disorder ": 2.705621617436817, "Corneal epithelium defect ": 3.0279207656230938, "Corneal erosion ": 2.9451976209850206, "Corneal infiltrates ": 2.508694369401621, "Corneal oedema ": 3.5397183472182707, "Corneal opacity ": 2.7483156997789377, "Corneal pigmentation ": 2.1706108345009483, "Coronary angioplasty ": 5.477499009509459, "Corpora cavernosa surgery ": 35.92416861404185, "Cotard's syndrome ": 2.059807064143012, "Craniofacial deformity ": 8.82757320125621, "Craniopharyngioma ": 5.236119233706769, "Craniosynostosis ": 15.750694915829232, "Crime ": 2.141940521401468, "Cross sensitivity reaction ": 5.287401002199151, "Crush syndrome ": 2.5460556445726743, "Crying ": 2.015615364465544, "Cryptorchism ": 3.845950705645684, "Crystal deposit intestine ": 3.6909512834391984, "Crystal nephropathy ": 2.4389865954265604, "Crystalluria ": 3.135090396078424, "Cutis laxa ": 2.154150020697041, "Cyanosis ": 2.958375563029909, "Cyanosis central ": 2.8695673302871256, "Cyanosis neonatal ": 4.442290807349576, "Cyclothymic disorder ": 2.863469777983985, "Cytogenetic abnormality ": 2.4205435959050567, "Dacryostenosis acquired ": 3.992785387049844, "Dacryostenosis congenital ": 3.8654239520323976, "Dandruff ": 4.985036164393428, "Deafness congenital ": 2.579042981685236, "Death neonatal ": 2.0167291437154518, "Decompensated hypothyroidism ": 4.122521220703462, "Decorticate posture ": 2.431575004969513, "Defect conduction intraventricular ": 2.4852296067555475, "Defiant behaviour ": 3.1582598847212897, "Deformity thorax ": 2.7599328232409817, "Delayed fontanelle closure ": 2.0464318866351654, "Delayed recovery from anaesthesia ": 4.414367719550118, "Delirium ": 2.108173550945074, "Delirium tremens ": 2.289587896539256, "Delusion ": 2.129155449540047, "Delusional disorder, unspecified type ": 2.20912144544718, "Dementia Alzheimer's type ": 2.0523851731833904, "Dental plaque ": 2.1366854047680577, "Dentofacial anomaly ": 5.194688139804288, "Dependence ": 5.894619681387182, "Depersonalisation/derealisation disorder ": 3.5295148955274684, "Depilation ": 2.356026082357269, "Deposit eye ": 2.778568784081628, "Depressed level of consciousness ": 2.487718266299383, "Derealisation ": 2.444646997154896, "Dermal absorption impaired ": 9.529860179479076, "Dermatillomania ": 2.0186452439690656, "Dermatitis allergic ": 2.0055263816926483, "Dermatitis bullous ": 2.450141480073126, "Dermatitis contact ": 3.5607244408422694, "Dermatitis diaper ": 2.1444215425600053, "Dermatitis exfoliative ": 2.731070490524626, "Dermatitis exfoliative generalised ": 2.849320693544969, "Developmental coordination disorder ": 12.617776279756622, "Developmental delay ": 6.400478729412912, "Developmental hip dysplasia ": 2.425933965096201, "Developmental regression ": 2.468797304151005, "Device alarm issue ": 2.637673923603099, "Device allergy ": 2.3778832419943305, "Device breakage ": 2.039619468907754, "Device capturing issue ": 3.787364818909382, "Device colour issue ": 3.99137987232265, "Device connection issue ": 2.8178149482102506, "Device delivery system issue ": 3.2405284963705507, "Device dispensing error ": 2.415129997857277, "Device expulsion ": 2.156916737865857, "Device failure ": 3.9669781721215625, "Device ineffective ": 8.10471951408704, "Device infusion issue ": 3.057660323197817, "Device malfunction ": 2.2658046580962816, "Device material issue ": 2.05052867485809, "Device pacing issue ": 8.518300179610732, "Device physical property issue ": 2.5249763183370035, "Device placement issue ": 3.1582598847212897, "Device power source issue ": 4.717673034412784, "Device programming error ": 8.413232666285767, "Device safety feature issue ": 4.705583054188087, "Device toxicity ": 4.406448101978552, "Device use error ": 4.719271362286081, "Device use issue ": 2.5091401113766705, "Dextrocardia ": 4.386797935305641, "DiGeorge's syndrome ": 3.0265595087464576, "Diabetes insipidus ": 2.7536556613705887, "Diagnostic procedure ": 2.654715123360537, "Diaphragmatic paralysis ": 2.0212289754145263, "Dihydrotestosterone decreased ": 6.78597621727484, "Dilatation ventricular ": 3.2233667657231773, "Disorganised speech ": 2.003948003577824, "Disorientation ": 2.1165285530674067, "Dissociation ": 2.373132342606381, "Dissociative disorder ": 2.7194376992975915, "Distributive shock ": 3.37537800876425, "Disturbance in sexual arousal ": 3.8228199897022175, "Diverticulum ": 4.010707104851753, "Diverticulum intestinal ": 4.497157838323047, "Diverticulum oesophageal ": 2.7801871827442293, "Documented hypersensitivity to administered product ": 10.625589676789732, "Dose calculation error ": 2.780840424534706, "Double outlet right ventricle ": 2.9195418840675096, "Drooling ": 2.388198772813209, "Drowning ": 2.0038374546137248, "Drug abuse ": 7.065219516060858, "Drug abuser ": 12.346806829450482, "Drug chemical incompatibility ": 12.201030850933437, "Drug delivery system issue ": 5.12370747165833, "Drug delivery system removal ": 4.570305539412523, "Drug dependence ": 5.892711789397809, "Drug dependence, antepartum ": 2.6556073102073143, "Drug diversion ": 4.189458598481271, "Drug dose omission by device ": 2.407482081097301, "Drug eruption ": 2.6447027181899867, "Drug interaction ": 2.56571895511184, "Drug level above therapeutic ": 3.955919432112195, "Drug level decreased ": 2.138355254123373, "Drug level fluctuating ": 3.2520925913554986, "Drug level increased ": 3.527409414526013, "Drug monitoring procedure incorrectly performed ": 3.68835493648122, "Drug monitoring procedure not performed ": 2.499286384766875, "Drug reaction with eosinophilia and systemic symptoms ": 3.893697904017204, "Drug rehabilitation ": 2.325722557999482, "Drug screen false positive ": 3.2034584186415667, "Drug specific antibody absent ": 2.538344019046156, "Drug therapeutic incompatibility ": 9.92549416813464, "Drug tolerance increased ": 3.078200487967968, "Drug use disorder ": 4.840316325346827, "Drug withdrawal convulsions ": 7.484072770518285, "Drug withdrawal headache ": 3.2927905000069786, "Drug withdrawal maintenance therapy ": 3.601654780680706, "Drug withdrawal syndrome ": 2.022715174889647, "Drug withdrawal syndrome neonatal ": 2.1841858823059424, "Drug-disease interaction ": 2.573367417528411, "Drug-induced liver injury ": 2.0975507988261084, "Ductus arteriosus premature closure ": 5.481454892736287, "Ductus arteriosus stenosis foetal ": 6.683113646453936, "Duplicate therapy error ": 3.933202838056386, "Dysaesthesia pharynx ": 12.772471136345011, "Dysarthria ": 2.146945856375951, "Dysbiosis ": 2.344158679059403, "Dyscalculia ": 3.7203553065899935, "Dysdiadochokinesis ": 2.617736458462352, "Dysgraphia ": 2.5887014094247687, "Dyskinesia ": 2.4554988461062046, "Dyskinesia neonatal ": 2.461877076965808, "Dyslalia ": 2.4533378158691965, "Dyslexia ": 3.499241884108153, "Dysmetria ": 2.832645681281876, "Dysmetropsia ": 3.5424778899304763, "Dysmorphism ": 11.838128282423618, "Dysphemia ": 2.2266635461189845, "Dyspraxia ": 4.620967182930328, "Dystonia ": 2.677968138049039, "Ear malformation ": 2.710195527047615, "Ear, nose and throat disorder ": 20.003002129228943, "Ebstein's anomaly ": 5.813785581687294, "Echolalia ": 4.91416801219962, "Eclampsia ": 3.944101558416704, "Ectopic pregnancy under hormonal contraception ": 4.087854129026545, "Ectrodactyly ": 2.270709421972378, "Educational problem ": 7.835082602018325, "Egocentrism ": 3.615082672656949, "Ejaculation delayed ": 3.060396797059034, "Ejaculation disorder ": 3.396604241994385, "Ejaculation failure ": 3.941122329958113, "Elastosis perforans ": 5.879276102958377, "Electrocardiogram P wave abnormal ": 2.6026397839377307, "Electrocardiogram PR prolongation ": 2.77772294951808, "Electrocardiogram QRS complex ": 2.1487608395327937, "Electrocardiogram QRS complex abnormal ": 2.2111223174168164, "Electrocardiogram QRS complex prolonged ": 7.245943164411023, "Electrocardiogram QRS complex shortened ": 5.469820429167827, "Electrocardiogram QT prolonged ": 2.521173385843104, "Electrocardiogram QT shortened ": 3.123254254014722, "Electrocardiogram ST segment abnormal ": 2.858006846205243, "Electrocardiogram ST segment depression ": 2.987554282438776, "Electrocardiogram ST segment elevation ": 2.168250195313933, "Electrocardiogram ST-T segment abnormal ": 2.7538219158768213, "Electrocardiogram ST-T segment depression ": 2.059807064143012, "Electrocardiogram T wave abnormal ": 2.080117867805221, "Electrocardiogram T wave amplitude decreased ": 2.2871112423576205, "Electrocardiogram T wave amplitude increased ": 3.4027766816184544, "Electrocardiogram T wave inversion ": 2.711743963238393, "Electrocardiogram T wave peaked ": 2.727197458792604, "Electrocardiogram U-wave abnormality ": 6.8031563798956105, "Electrocardiogram abnormal ": 2.135463740002004, "Electrocardiogram change ": 3.2273844410884927, "Electrocardiogram repolarisation abnormality ": 2.630327964366432, "Electroencephalogram abnormal ": 3.1477598554496407, "Embedded device ": 4.826380696809855, "Embolia cutis medicamentosa ": 6.854608928972396, "Emergency care ": 3.139681335515045, "Emergency care examination ": 6.326282897596922, "Emotional disorder ": 2.183317074436155, "Emotional disorder of childhood ": 2.037812422706561, "Emotional poverty ": 3.421834528426761, "Empty sella syndrome ": 4.406825286148448, "Enanthema ": 2.4848376641965126, "Encapsulating peritoneal sclerosis ": 3.183863684710422, "Encephalitis mumps ": 2.158702033383775, "Encephalomalacia ": 2.0331920372538743, "Encephalopathy ": 2.4090440867277128, "Encephalopathy neonatal ": 2.0495228807388, "Encopresis ": 6.122567086251918, "Endocardial fibroelastosis ": 3.018316396517281, "Endometrial disorder ": 3.5785656896673106, "Endometrial hyperplasia ": 2.300546978580927, "Endometrial thickening ": 2.144268970885839, "Endometritis ": 2.792561727127509, "Endotoxic shock ": 4.147715741662421, "Endotracheal intubation complication ": 2.940836801598202, "Enterocolitis haemorrhagic ": 2.188235192217729, "Enuresis ": 3.5410476536119364, "Environmental exposure ": 2.7144895211211426, "Eosinophilia ": 2.800096310678105, "Eosinophilic cystitis ": 2.792889305099717, "Eosinophilic granulomatosis with polyangiitis ": 2.8659241770403114, "Eosinophilic myocarditis ": 2.091186638446401, "Eosinophilic oesophagitis ": 3.326418747837527, "Eosinophilic pleural effusion ": 3.2627323947230757, "Eosinophilic pneumonia acute ": 2.0261695015722414, "Epidermal necrosis ": 2.114081631073484, "Epidermolysis bullosa ": 2.330291924802159, "Epididymal cyst ": 5.173761806797733, "Epiglottic oedema ": 2.4902575120634944, "Epilepsy ": 2.0959722503844254, "Epiphyseal disorder ": 6.249107449882757, "Epiphyses premature fusion ": 4.047972505381089, "Epiphysiolysis ": 4.130712470204268, "Erectile dysfunction ": 3.208301401869256, "Erosive duodenitis ": 2.5998609390397287, "Erosive oesophagitis ": 2.217156186107702, "Erythema multiforme ": 2.479546196814607, "Erythema of eyelid ": 2.135826209204301, "Erythropenia ": 2.837061924840992, "Erythrosis ": 2.0558291541649525, "Euphoric mood ": 2.0109994037351173, "Evacuation of retained products of conception ": 6.406470326786169, "Excessive sexual fantasies ": 3.487298748185552, "Executive dysfunction ": 4.214356309415495, "Exomphalos ": 3.629204653585501, "Expired device used ": 2.097026550916415, "Expired product administered ": 3.442835123113705, "Exposure to contaminated device ": 2.387043285011238, "Exposure to toxic agent ": 3.036245348071156, "Exposure via blood ": 4.802594096429057, "Exposure via eye contact ": 4.385314579180378, "Exposure via ingestion ": 4.397641702896371, "Exposure via inhalation ": 2.6974128087585774, "Expulsion of medication ": 10.338195159448963, "Extensor plantar response ": 3.22318629535282, "Extradural haematoma ": 2.0117790350714846, "Extrapyramidal disorder ": 2.5703932687781457, "Extravasation ": 4.223151899885759, "Eye complication associated with device ": 2.1487608395327937, "Eye degenerative disorder ": 2.387467590390321, "Eye infection intraocular ": 7.614347480759988, "Eye movement disorder ": 2.128595587028045, "Eye oedema ": 2.215526669831582, "Eyelid erosion ": 3.2191414182460285, "Eyelid oedema ": 2.852397454504708, "Eyelid ptosis congenital ": 3.109802340156836, "Face oedema ": 3.082956424073913, "Factor II deficiency ": 6.952804379260789, "Factor VII deficiency ": 2.654715123360537, "Faecal vomiting ": 2.125622382723944, "Faecaloma ": 2.816818709399569, "Faeces hard ": 2.038881743899592, "Faeces pale ": 2.5332242044362623, "Failed in vitro fertilisation ": 2.3793318554953204, "Fallot's tetralogy ": 8.99204728137524, "False negative investigation result ": 4.688436715608479, "False positive investigation result ": 2.0015339580178004, "Fat embolism ": 3.7005894790151976, "Fear ": 2.385596435484848, "Fear of death ": 2.165824618148924, "Fear of disease ": 3.5531329557506397, "Febrile convulsion ": 3.360910891301883, "Febrile nonhaemolytic transfusion reaction ": 2.5266024138001204, "Feeling jittery ": 2.254664772833481, "Feelings of worthlessness ": 3.484395605044972, "Female orgasmic disorder ": 3.571431063313624, "Female sexual dysfunction ": 3.3921150717170643, "Feminisation acquired ": 3.5148518229747605, "Femoral anteversion ": 2.3465532070172253, "Femoral artery dissection ": 2.387804269380746, "Femoral nerve palsy ": 4.743659412034792, "Fibrin degradation products increased ": 2.0373250893473926, "Fibrocystic breast disease ": 3.08188442077795, "Fibroma ": 2.059191488784373, "Fight in school ": 4.406448101978552, "Fine motor delay ": 5.756935901160102, "Fixed eruption ": 5.581241084105412, "Flap necrosis ": 4.802594096429057, "Flashback ": 2.519817039689048, "Flat anterior chamber of eye ": 5.896765777660648, "Flight of ideas ": 2.4710532678765573, "Floppy infant ": 2.284346863724446, "Floppy iris syndrome ": 9.18078064038258, "Fluid replacement ": 2.4793349669065576, "Flushing ": 2.3398926738851915, "Foaming at mouth ": 3.2259250312244188, "Foetal acidosis ": 3.1582598847212897, "Foetal alcohol syndrome ": 3.6147353771008457, "Foetal anticonvulsant syndrome ": 56.60793198935472, "Foetal arrhythmia ": 2.1596009473666915, "Foetal biophysical profile score abnormal ": 3.487298748185552, "Foetal damage ": 3.859879244102083, "Foetal disorder ": 2.061906266219399, "Foetal distress syndrome ": 2.021924147383038, "Foetal exposure during delivery ": 4.746941806689264, "Foetal exposure during pregnancy ": 3.4075454519191566, "Foetal exposure timing unspecified ": 2.540516527616836, "Foetal heart rate abnormal ": 2.1146288162081905, "Foetal heart rate decreased ": 2.932063811107728, "Foetal heart rate disorder ": 4.979405671064821, "Foetal heart rate increased ": 2.040534036553507, "Foetal monitoring abnormal ": 3.5304547010535843, "Foetal non-stress test abnormal ": 3.110179983811206, "Foetal warfarin syndrome ": 14.94675601383527, "Fontanelle bulging ": 2.0895536841468973, "Food interaction ": 3.44519585305426, "Foreign body aspiration ": 5.664074894467893, "Foreign body in gastrointestinal tract ": 3.112300009500563, "Foreign body in mouth ": 9.248258253748087, "Foreign body in respiratory tract ": 2.962524686275257, "Foreign body in throat ": 4.211819422326996, "Fracture of penis ": 18.168891145059757, "Fungal peritonitis ": 2.4949302428072717, "Galactorrhoea ": 4.228099880272463, "Gallbladder cancer ": 4.191688272364003, "Gambling ": 2.2942244644057808, "Gamma-glutamyltransferase increased ": 2.222497590153365, "Gastric cancer ": 8.347281463402279, "Gastric cancer stage IV ": 2.329282992563667, "Gastric lavage ": 4.688159595029086, "Gastric mucosa erythema ": 2.23731833874971, "Gastric mucosal hypertrophy ": 2.1497644818720323, "Gastric polyps ": 2.833022295722777, "Gastritis erosive ": 2.379954071165153, "Gastroenteritis staphylococcal ": 2.060661229853793, "Gastrointestinal carcinoma ": 5.897675203799092, "Gastrointestinal disorder congenital ": 2.1389058749145065, "Gastrointestinal malformation ": 2.0414027323249155, "Gastrointestinal sounds abnormal ": 2.406696308992664, "Gastrointestinal stoma output decreased ": 3.1548067533935624, "Gastrointestinal tract mucosal discolouration ": 2.154150020697041, "Gastrointestinal tract mucosal pigmentation ": 5.561076207242002, "Gastrooesophageal sphincter insufficiency ": 3.8425457006871793, "Gastroschisis ": 4.008083520529888, "Gaze palsy ": 2.948566669567294, "General anaesthesia ": 3.524007618038884, "Generalised bullous fixed drug eruption ": 2.23656444563837, "Generalised tonic-clonic seizure ": 2.639437953824304, "Genital anaesthesia ": 6.272130450456058, "Genital atrophy ": 7.229322137377884, "Genital hypoaesthesia ": 4.030809328257837, "Genital paraesthesia ": 2.380186294720142, "Gingival discomfort ": 2.3338705466510508, "Gingival erosion ": 2.34264995267084, "Gingival erythema ": 2.1539091030294992, "Gingival hyperpigmentation ": 2.387804269380746, "Gingival hypertrophy ": 2.821325483550392, "Gingival oedema ": 2.557117244310146, "Gitelman's syndrome ": 3.615082672656949, "Glossitis ": 2.2492331093831672, "Glossoptosis ": 4.767900239223762, "Gluten sensitivity ": 2.0451769405011837, "Grandiosity ": 2.1468283283529, "Granulocytopenia ": 3.2201607327241057, "Grey syndrome neonatal ": 2.5907254632306738, "Grief reaction ": 2.2259207123210967, "Gross motor delay ": 5.949776680630173, "Growth accelerated ": 2.216280710420783, "Growth retardation ": 3.9330467254331314, "Gun shot wound ": 3.0802216977826347, "Gynaecomastia ": 3.803797207469064, "HELLP syndrome ": 2.6292082527673264, "Haemangioma congenital ": 3.308970672206197, "Haemarthrosis ": 2.2772461758699483, "Haematological malignancy ": 2.1703606170079426, "Haematoma muscle ": 3.43351140776761, "Haemoconcentration ": 2.650056585819588, "Haemodialysis complication ": 2.720993284414149, "Haemodynamic instability ": 2.167595303249528, "Haemoperitoneum ": 2.4788470182341094, "Haemorrhagic disorder ": 2.04733162588644, "Haemorrhoids ": 2.645297048125697, "Hair growth abnormal ": 2.917848069074385, "Hair texture abnormal ": 2.470081556627413, "Hair transplant ": 10.633026989774171, "Hallucination ": 2.418073440833141, "Hallucination, visual ": 2.67856468673834, "Hallucinations, mixed ": 2.567604466216125, "Harlequin syndrome ": 2.2450342229325893, "Head circumference abnormal ": 2.0301784492250383, "Head deformity ": 3.586585324006094, "Heart block congenital ": 2.6974128087585774, "Heart disease congenital ": 6.039561546973297, "Heart sounds abnormal ": 2.272948378406922, "Helicobacter gastritis ": 2.685437891924619, "Helicobacter test positive ": 2.2107096800193835, "Hemianopia heteronymous ": 2.589912226151715, "Henoch-Schonlein purpura ": 2.2455087807647858, "Heparin-induced thrombocytopenia ": 10.182253128045916, "Heparin-induced thrombocytopenia test ": 9.293779407489364, "Hepatic adenoma ": 2.52244442391094, "Hepatic atrophy ": 2.624735161095654, "Hepatic cancer ": 3.804735377848458, "Hepatic function abnormal ": 2.51863494617491, "Hepatic necrosis ": 2.6082047638926658, "Hepatic vein dilatation ": 2.1384350701399795, "Hepatitis acute ": 2.8892017832673718, "Hepatitis cholestatic ": 4.64496202752805, "Hepatitis fulminant ": 2.746647205373114, "Hepatitis non-A non-B ": 2.2450342229325893, "Hepatitis toxic ": 2.9248328510803927, "Hepato-lenticular degeneration ": 2.936222849208289, "Hepatocellular injury ": 2.9007881682328405, "Herbal interaction ": 3.183863684710422, "Hereditary angioedema ": 9.62923465902985, "Hereditary angioedema with C1 esterase inhibitor deficiency ": 2.4674108568917084, "Hernia congenital ": 2.6473914494403386, "Hernia hiatus repair ": 3.053687468309727, "Heterophoria ": 3.38955926305894, "Heterotopic pregnancy ": 4.198672806064916, "Hiatus hernia ": 3.717612659088181, "Hiccups ": 2.697561980184705, "High arched palate ": 6.536504304697172, "Hirsutism ": 2.208457376984849, "Histology abnormal ": 2.065602363262541, "Histone antibody positive ": 2.9024745245448345, "Holoprosencephaly ": 2.279796500993944, "Homicidal ideation ": 2.303396878402684, "Homicide ": 4.9188043205911285, "Hostility ": 2.5214045148074486, "Human chorionic gonadotropin increased ": 5.981185033238219, "Human herpes virus 6 serology positive ": 2.515908217122853, "Huntington's disease ": 6.067551201987004, "Hydrocele ": 2.357795821263958, "Hydrops foetalis ": 2.5623980667993767, "Hyperaemia ": 2.9507218982906527, "Hyperammonaemia ": 4.879844631007289, "Hyperammonaemic encephalopathy ": 6.520156493951414, "Hypercalciuria ": 2.611264679283238, "Hypercapnic coma ": 3.2440154132938024, "Hyperchloraemia ": 3.617785709438192, "Hyperglobulinaemia ": 6.302341794921743, "Hyperintensity in brain deep nuclei ": 3.9356187523285056, "Hyperkalaemia ": 3.874320612166048, "Hyperkinesia ": 3.485160604075505, "Hyperkinetic heart syndrome ": 3.6147353771008457, "Hyperlactacidaemia ": 2.3397876309059, "Hypermagnesaemia ": 6.187028974283551, "Hypernatraemia ": 2.8485310982203207, "Hyperoxaluria ": 2.441393592880345, "Hyperparathyroidism primary ": 2.955484858645617, "Hyperprolactinaemia ": 2.648386313802924, "Hyperreflexia ": 3.889250719444564, "Hypersensitivity myocarditis ": 2.068190904451604, "Hypersensitivity vasculitis ": 2.502849739652757, "Hypertelorism ": 9.826484057423494, "Hypertension neonatal ": 3.0390232848659395, "Hyperthermia ": 2.148161078465519, "Hyperthermia malignant ": 3.1507725390669017, "Hypertonia ": 3.8665451334302094, "Hypertonia neonatal ": 6.574430879129772, "Hypertrichosis ": 4.681538921448591, "Hypervigilance ": 2.064737156590052, "Hypervitaminosis ": 2.070447818919116, "Hypervitaminosis A ": 2.848173647013041, "Hypervitaminosis D ": 3.018316396517281, "Hypocalvaria ": 5.39741127910699, "Hypocapnia ": 2.196982643309022, "Hypocarnitinaemia ": 8.009118968725161, "Hypochloraemia ": 5.018499096748638, "Hypocholesterolaemia ": 2.6215031579876475, "Hypocitraturia ": 4.802594096429057, "Hypocoagulable state ": 14.64569272558812, "Hypogonadism ": 3.9486427027687303, "Hypogonadism male ": 2.9839020141957677, "Hypohidrosis ": 4.17329705998042, "Hypokalaemia ": 5.568785019220675, "Hypokinesia neonatal ": 5.198964971256344, "Hyponatraemia ": 4.209493603969707, "Hyponatraemic encephalopathy ": 8.061190422622072, "Hyponatraemic seizure ": 5.10847007168488, "Hyponatraemic syndrome ": 4.140350862180093, "Hypoosmolar state ": 2.83139323334466, "Hypoperfusion ": 2.417515590433675, "Hypoplastic anaemia ": 4.141223174152671, "Hypoplastic left heart syndrome ": 9.65798831717102, "Hypoplastic right heart syndrome ": 5.731706343934361, "Hypoprothrombinaemia ": 14.45160416332334, "Hyporeflexia ": 2.222396374569204, "Hypospadias ": 7.868995535344396, "Hyposthenuria ": 3.07919380766695, "Hypotelorism of orbit ": 6.78597621727484, "Hypotension ": 2.5994171717639523, "Hypotensive transfusion reaction ": 6.272130450456058, "Hypothalamic pituitary adrenal axis suppression ": 3.086561168593964, "Hypothermia ": 2.33410298962818, "Hypothermia neonatal ": 2.4815607600334006, "Hypothrombinaemia ": 2.762913163152542, "Hypotonia neonatal ": 7.266012887858744, "Hypotony of eye ": 2.203448711752774, "Hypotrichosis ": 2.0301784492250383, "Hypoventilation ": 2.085488309373476, "Hypoventilation neonatal ": 2.154150020697041, "Hypovolaemia ": 2.023729014112016, "Hypoxic-ischaemic encephalopathy ": 2.135755002766772, "Hypozincaemia ": 7.408067933199498, "Hysteroscopy ": 5.172121072992665, "Iatrogenic injury ": 2.59678681761694, "Ideas of reference ": 2.7893707053248438, "Idiopathic intracranial hypertension ": 2.704367944583116, "Idiosyncratic drug reaction ": 3.752291490910505, "Ileus paralytic ": 2.8170180141291388, "Illiteracy ": 2.140171203093644, "Impaired driving ability ": 2.0811565734846176, "Impaired reasoning ": 2.662923799026622, "Impatience ": 2.1065616452886915, "Implant site haematoma ": 2.531466042797645, "Implant site reaction ": 4.705583054188087, "Implantation complication ": 5.338774251570324, "Impulsive behaviour ": 3.0792959174125096, "Inability to afford medication ": 2.596063513114127, "Inadequate analgesia ": 4.13524740584665, "Inadequate lubrication ": 3.487298748185552, "Inappropriate affect ": 2.5877278709604017, "Inappropriate antidiuretic hormone secretion ": 4.042461779876607, "Incision site haematoma ": 2.8865086325763807, "Incoherent ": 2.128198867886594, "Incorrect dosage administered ": 2.5920021777620508, "Incorrect dose administered by product ": 2.923384706208534, "Incorrect drug administration rate ": 3.412071858392461, "Incorrect product administration duration ": 3.729277548026035, "Incorrect product dosage form administered ": 3.177754976232754, "Incorrect product formulation administered ": 2.127358162107789, "Indifference ": 2.8392493690905973, "Induced abortion failed ": 298.2484284628898, "Induced abortion haemorrhage ": 3.442779540174401, "Infantile apnoea ": 3.448681650578457, "Infantile spasms ": 2.8970580602378413, "Infection via vaccinee ": 2.154150020697041, "Infertility male ": 5.063403774760271, "Infusion site extravasation ": 2.7848923619466923, "Infusion site granuloma ": 4.689831001001493, "Infusion site inflammation ": 2.7021461556511475, "Infusion site necrosis ": 2.4699264535838386, "Infusion site oedema ": 3.111937376872949, "Infusion site phlebitis ": 6.692700128478317, "Inhalation therapy ": 19.0111691735073, "Inhibitory drug interaction ": 2.2362220639573427, "Injection site granuloma ": 4.831281054603175, "Injection site hypertrichosis ": 3.442779540174401, "Injection site ischaemia ": 7.136878144484689, "Injection site joint inflammation ": 2.7801871827442293, "Injection site laceration ": 4.773427223895921, "Injection site necrosis ": 2.140831190131402, "Injection site pallor ": 4.995997872223249, "Injection site phlebitis ": 12.442638870519998, "Injection site thrombosis ": 5.54755357753633, "Instillation site erythema ": 4.9551076627161, "Instillation site foreign body sensation ": 3.5148518229747605, "Instillation site irritation ": 4.469397015128806, "Instillation site pruritus ": 2.119843710264686, "Insulin-like growth factor decreased ": 4.920891343497318, "Insulin-like growth factor increased ": 4.910833575490411, "Intellectual disability ": 5.877015326170559, "Intelligence test abnormal ": 4.593336151050352, "Intention tremor ": 2.2968835216399444, "Intentional device misuse ": 5.910703605176792, "Intentional device use issue ": 2.1447791014765603, "Intentional misuse of drug delivery system ": 9.167961729456698, "Intentional overdose ": 6.257861830906898, "Intentional product misuse ": 3.517618132289173, "Intentional product misuse to child ": 2.4699264535838386, "Intentional removal of drug delivery system by patient ": 4.388694975075853, "Intentional self-injury ": 6.770219572095157, "Intercepted product prescribing error ": 2.2517713372367423, "Intermittent explosive disorder ": 2.589912226151715, "Internal hernia ": 2.0381992078055684, "Internal injury ": 2.154232826945312, "International normalised ratio ": 3.71029999959756, "International normalised ratio abnormal ": 4.05104163212557, "International normalised ratio decreased ": 4.29020541406559, "International normalised ratio fluctuation ": 6.017369906330414, "International normalised ratio increased ": 7.635049036833043, "Interruption of aortic arch ": 2.738922347820625, "Intestinal angioedema ": 20.70010675939629, "Intestinal atony ": 2.184478674164116, "Intestinal diaphragm disease ": 10.368582664778728, "Intestinal haematoma ": 4.8844696433317205, "Intestinal intraepithelial lymphocytes increased ": 5.030340738416564, "Intestinal metaplasia ": 2.4268961105938494, "Intestinal mucosal atrophy ": 3.77657001277882, "Intestinal pseudo-obstruction ": 2.7898954726195164, "Intestinal strangulation ": 2.141940521401468, "Intestinal villi atrophy ": 7.674203765957176, "Intra-abdominal haematoma ": 3.878139371022612, "Intra-abdominal haemorrhage ": 2.249400365974449, "Intraventricular haemorrhage neonatal ": 4.637751870891568, "Intrusive thoughts ": 2.35103832431833, "Invasive ductal breast carcinoma ": 4.165501834746796, "Invasive lobular breast carcinoma ": 3.2138035809535523, "Iodine uptake decreased ": 3.457645315486185, "Iridotomy ": 2.158702033383775, "Iris atrophy ": 2.163947849098682, "Iris disorder ": 2.490319740474784, "Iris hypopigmentation ": 13.164543590896496, "Iris transillumination defect ": 32.63103118347658, "Ischaemic gastritis ": 3.5148518229747605, "Jarisch-Herxheimer reaction ": 5.731858389088097, "Jaundice ": 2.3162581232411776, "Jaundice cholestatic ": 2.55630729006296, "Joint hyperextension ": 2.330669416153329, "Judgement impaired ": 3.4935845418473277, "Keratomileusis ": 3.018048574023795, "Kernicterus ": 2.5907254632306738, "Kidney malformation ": 3.684371222587131, "Knee deformity ": 3.025392311614878, "Kounis syndrome ": 3.9023465109457542, "Labelled drug-disease interaction medication error ": 5.231059677944292, "Labelled drug-food interaction issue ": 4.000509736211133, "Labelled drug-food interaction medication error ": 2.005000870635928, "Laboratory test interference ": 2.7501301876753126, "Labour augmentation ": 5.198964971256344, "Labour complication ": 2.2990917653458, "Lacrimation decreased ": 2.0063382529418163, "Lacrimation disorder ": 2.413910384021141, "Lactate pyruvate ratio increased ": 2.119843710264686, "Lactic acidosis ": 4.654093293193839, "Large intestine polyp ": 4.937059921241006, "Laryngeal discomfort ": 2.650206510753934, "Laryngeal dyspnoea ": 4.587349568439264, "Laryngeal haematoma ": 2.356026082357269, "Laryngeal oedema ": 4.274417860326705, "Laryngeal pain ": 2.249578507082471, "Laryngomalacia ": 2.581452788607616, "Laryngospasm ": 4.358067288577303, "Laryngotracheal oedema ": 9.458141235220344, "Laryngotracheal operation ": 5.198964971256344, "Larynx irritation ": 2.023886935467474, "Learning disability ": 4.463229935315746, "Learning disorder ": 10.048640591924991, "Left ventricle outflow tract obstruction ": 3.859667713920546, "Leucine aminopeptidase increased ": 12.220140829168235, "Leuconostoc infection ": 2.6556073102073143, "Leukaemoid reaction ": 2.287399874957282, "Leukocyte alkaline phosphatase increased ": 4.300975156186353, "Leukocytosis ": 2.1871848229354702, "Leukonychia ": 2.224121452268076, "Libido decreased ": 4.8946350951620925, "Libido disorder ": 2.2930071897638866, "Life expectancy shortened ": 12.865521889241586, "Life support ": 3.3226791819194994, "Ligament laxity ": 3.552772685977802, "Limb asymmetry ": 2.8422024405568638, "Limb hypoplasia congenital ": 6.639262375097111, "Limb reduction defect ": 4.373749325542392, "Linear IgA disease ": 7.122006539340007, "Lip disorder ": 2.201223209577031, "Lip erosion ": 2.5478623390386144, "Lip erythema ": 2.4876892533848878, "Lip exfoliation ": 2.001389135307804, "Lip oedema ": 4.97136957254804, "Lip swelling ": 2.079295260197871, "Lipogranuloma ": 2.6556073102073143, "Lissencephaly ": 2.739337169947462, "Liver palpable ": 3.215202769711489, "Local anaesthetic systemic toxicity ": 3.0624739922083037, "Loeffler's syndrome ": 3.792326896754684, "Logorrhoea ": 3.702026827524416, "Long QT syndrome ": 3.975022039769379, "Long QT syndrome congenital ": 4.155425732610098, "Loose associations ": 2.5322569562112758, "Lordosis ": 2.537397259285423, "Loss of employment ": 4.636509986348207, "Loss of libido ": 5.44038396549083, "Low density lipoprotein decreased ": 3.778876509953263, "Low set ears ": 3.094654202318216, "Lung carcinoma cell type unspecified stage I ": 3.438562821726312, "Lung carcinoma cell type unspecified stage III ": 2.045240671351275, "Lung neoplasm malignant ": 2.650877455908001, "Lung operation ": 2.434975583340463, "Lymphocyte morphology abnormal ": 2.552822903877229, "Lymphocyte stimulation test ": 3.0938723142390154, "Lymphocyte stimulation test positive ": 5.669039459795369, "Macrocephaly ": 2.566265663764024, "Macroglossia ": 2.715043369295507, "Malabsorption ": 6.96587064876283, "Malabsorption from application site ": 4.300975156186353, "Malaria ": 2.0212289754145263, "Male genital atrophy ": 4.934436336095037, "Male orgasmic disorder ": 6.265623095496101, "Male reproductive tract disorder ": 3.223244446764583, "Male sexual dysfunction ": 3.7249674127896375, "Malocclusion ": 3.709147026364101, "Mammogram abnormal ": 3.880291025884471, "Mania ": 3.5628549587428404, "Manufacturing issue ": 4.087854129026545, "Manufacturing materials issue ": 2.8181737538583063, "Marfan's syndrome ": 4.680092339331298, "Marital problem ": 3.75078864372996, "Mastectomy ": 2.040054694944704, "Maternal drugs affecting foetus ": 5.452461991893415, "Maternal exposure during delivery ": 7.157070214281162, "Mean arterial pressure decreased ": 2.102911391962367, "Measles ": 6.399006905116629, "Measles antibody negative ": 2.790604720356131, "Measles post vaccine ": 5.085845879805, "Meconium abnormal ": 4.469397015128806, "Meconium in amniotic fluid ": 4.022890261345194, "Medication crystals in urine present ": 3.615082672656949, "Medication error ": 3.132963184388722, "Medication overuse headache ": 2.142964164603532, "Medulloblastoma ": 2.151954624278827, "Megacolon ": 2.325530409594286, "Melanosis ": 3.4178729931212524, "Meningioma ": 3.155245049152494, "Meningitis chemical ": 2.216989853625224, "Meningocele ": 3.226473374678685, "Meningomyelocele ": 4.76877766187732, "Mental disability ": 3.21688923472569, "Merycism ": 3.826423134070761, "Mesenteric haematoma ": 2.526902834298863, "Metabolic acidosis ": 2.862740252099892, "Metabolic alkalosis ": 5.491948514937654, "Metabolic encephalopathy ": 2.19872340019254, "Metal poisoning ": 2.3190259513510965, "Metanephrine urine increased ": 4.007036161400551, "Microcephaly ": 4.565595627530554, "Microgenia ": 2.0925266228089137, "Micrognathia ": 4.939258664128763, "Micropenis ": 2.182707492679382, "Microphthalmos ": 2.916728444196855, "Microvillous inclusion disease ": 3.6147353771008457, "Micturition disorder ": 2.3821266380902024, "Milk-alkali syndrome ": 3.358155988248352, "Mini mental status examination abnormal ": 2.5322569562112758, "Miosis ": 5.611761010374255, "Mitochondrial encephalomyopathy ": 2.0384881070613017, "Mitochondrial enzyme deficiency ": 2.848173647013041, "Mitral valve atresia ": 2.040534036553507, "Mitral valve sclerosis ": 2.219522144485229, "Mitral valve stenosis ": 2.1203067530260964, "Mixed liver injury ": 2.575762878304656, "Modified radical mastectomy ": 9.527343403928812, "Morbid thoughts ": 2.234088760968957, "Morbillivirus test positive ": 4.1423793880704975, "Morose ": 2.863469777983985, "Motor developmental delay ": 3.263020816914346, "Mouth swelling ": 3.4809418720626737, "Mucosa vesicle ": 2.7309725355112, "Mucosal erosion ": 3.1369432874498626, "Mucosal exfoliation ": 3.012772679945205, "Mucosal hyperaemia ": 2.6146608751144047, "Mucosal membrane hyperplasia ": 4.010584589699205, "Multiple cardiac defects ": 2.1384046678205544, "Multiple congenital abnormalities ": 9.817096270568506, "Multiple pregnancy ": 2.067710689608565, "Mumps ": 10.488353438609238, "Mumps antibody test negative ": 2.6282276649410377, "Muscle haemorrhage ": 2.192760636749671, "Muscle necrosis ": 3.1569513411924524, "Muscle rigidity ": 2.3687563847998536, "Muscle rupture ": 2.275859276764477, "Muscle tone disorder ": 2.154033910838173, "Musculoskeletal injury ": 7.603510004502053, "Mycobacterium ulcerans infection ": 18.312818235900263, "Mydriasis ": 5.07843861761456, "Myocardial depression ": 3.796835854988803, "Myocardial haemorrhage ": 2.0495228807388, "Myocardial stunning ": 10.792995139835782, "Myoclonus ": 3.4533882796224136, "Myofascitis ": 2.7354562412626264, "Myoglobin blood increased ": 2.600188106237404, "Myoglobin urine ": 2.3165222645963905, "Myoglobin urine present ": 2.976063820706978, "Myoglobinaemia ": 4.07007745522992, "Myoglobinuria ": 4.554983330015176, "Myopathy ": 3.3644495651859514, "Myopia ": 4.2726863339301975, "Narcissistic personality disorder ": 2.321372237564148, "Narrow anterior chamber angle ": 3.0265595087464576, "Nasal cavity cancer ": 6.810075230560672, "Nasal discomfort ": 2.231900859233242, "Nasal disorder ": 2.7592624802170604, "Nasal mucosal disorder ": 2.384665230385425, "Nasal pruritus ": 3.157489095767474, "Nasal septum perforation ": 3.349460294629244, "Nasal septum ulceration ": 7.977247753518294, "Nasopharyngeal cancer ": 2.703349121596609, "Near death experience ": 2.149740922028582, "Necrolytic migratory erythema ": 2.387804269380746, "Necrosis ischaemic ": 2.1840310555248794, "Necrotising colitis ": 3.608846172111333, "Needle issue ": 2.0235578051964285, "Needle track marks ": 4.893428407223816, "Negativism ": 2.0412460480762418, "Neonatal anoxia ": 2.1706108345009483, "Neonatal anuria ": 2.856126191322969, "Neonatal asphyxia ": 4.093710481331146, "Neonatal behavioural syndrome ": 3.1287473158599246, "Neonatal cholestasis ": 3.87893833691815, "Neonatal disorder ": 2.6325165099319694, "Neonatal hypotension ": 3.0041773045320355, "Neonatal hypoxia ": 3.6264816480187143, "Neonatal infection ": 3.3399747004831646, "Neonatal pneumothorax ": 3.018048574023795, "Neonatal respiratory arrest ": 2.4593523396094774, "Neonatal respiratory depression ": 3.631418343302053, "Neonatal respiratory distress ": 3.0466004827729294, "Neonatal respiratory distress syndrome ": 2.4411862062532084, "Neonatal respiratory failure ": 3.9826354958906576, "Neonatal seizure ": 4.794057847239342, "Neonatal tachycardia ": 2.489100169809212, "Neonatal tachypnoea ": 2.239033257618621, "Neonatal toxicity ": 5.5955177896771575, "Neoplasm malignant ": 2.5758538298588416, "Nephritis allergic ": 2.643496268847826, "Nephrocalcinosis ": 2.5658516979654964, "Nephrogenic diabetes insipidus ": 5.802790186340983, "Nephrogenic systemic fibrosis ": 2.309298947705535, "Nervousness ": 2.526693448266528, "Neural tube defect ": 9.12527190069441, "Neurectomy ": 2.8888362465479496, "Neurodevelopmental disorder ": 11.904228559389969, "Neuroleptic malignant syndrome ": 2.770869038728204, "Neuromuscular block prolonged ": 4.390618781840559, "Neuromuscular blockade ": 3.4457302777719123, "Neuromuscular blocking therapy ": 15.590822419093616, "Neuromyopathy ": 2.280959455756404, "Neuropsychological symptoms ": 6.357208008222257, "Neurotransmitter level altered ": 2.2215263940755143, "Neutralising antibodies positive ": 2.838782617585562, "Newborn persistent pulmonary hypertension ": 24.94847964235029, "Nicotine dependence ": 26.203675378634653, "Nicotinic acid deficiency ": 3.339546348012921, "Nightmare ": 2.33037598534243, "Nikolsky's sign ": 2.154046336827644, "Nipple disorder ": 3.051364619219909, "Nocturnal fear ": 2.7083890562614026, "Nodal arrhythmia ": 8.735195699572643, "Nodal rhythm ": 7.916898692157472, "Non-cardiogenic pulmonary oedema ": 2.5800671895893976, "Non-immune heparin associated thrombocytopenia ": 3.1877485848580447, "Noninfectious peritonitis ": 4.793129411962667, "Nonspecific reaction ": 2.303106799524413, "Nontherapeutic agent urine positive ": 3.5424778899304763, "Noonan syndrome ": 3.178702039398656, "Normetanephrine urine increased ": 3.487298748185552, "Nose deformity ": 6.451996972234148, "Nosophobia ": 4.300975156186353, "Nystagmus ": 2.839953917591586, "Obsessive thoughts ": 2.237770939281953, "Occupational asthma ": 2.2796882444559303, "Oculoauriculovertebral dysplasia ": 2.762913163152542, "Oculogyric crisis ": 3.363162173696292, "Oculomucocutaneous syndrome ": 4.644398536330027, "Oedema genital ": 2.323994115839095, "Oedema mouth ": 19.54644672009796, "Oedema mucosal ": 2.8637850970169896, "Oedema neonatal ": 2.5907254632306738, "Oesophageal carcinoma ": 15.796353934681983, "Oesophageal discomfort ": 2.838728414981406, "Oesophageal injury ": 2.83139323334466, "Oesophageal irritation ": 3.995992352689222, "Oesophageal obstruction ": 2.045398491126318, "Oesophageal oedema ": 2.0976434733784406, "Oesophageal pain ": 3.5285841559870312, "Oesophagitis chemical ": 4.172004983808182, "Oestradiol increased ": 4.375679922124095, "Oestrogen deficiency ": 2.748830212428649, "Oestrogen receptor assay positive ": 4.831632651095809, "Off label use of device ": 5.87698667678919, "Oligohydramnios ": 4.319353368958843, "Oligospermia ": 6.421723954633703, "Oliguria ": 3.030528413522446, "Onychophagia ": 2.999112472942262, "Opiates positive ": 2.387538094559576, "Opisthotonus ": 5.5302567009443, "Oppositional defiant disorder ": 3.555003800928013, "Optic nerve hypoplasia ": 5.172121072992665, "Oral administration complication ": 2.767046335723498, "Oral allergy syndrome ": 6.946393816732602, "Oral discharge ": 2.531466042797645, "Oral discomfort ": 3.334646751470425, "Oral mucosa erosion ": 3.0101624491095134, "Oral mucosal discolouration ": 2.860039857558307, "Oral mucosal eruption ": 2.829994390230411, "Oral mucosal erythema ": 3.286674079163142, "Oral mucosal exfoliation ": 2.6578987005891603, "Oral mucosal roughening ": 2.208597383915884, "Oral papule ": 4.910307140806525, "Oral pruritus ": 6.922923128016432, "Orbital haemorrhage ": 2.567861733067455, "Orbital oedema ": 2.7476276713017143, "Orchitis mumps ": 4.406448101978552, "Organic erectile dysfunction ": 3.661767206368689, "Orgasm abnormal ": 4.273314163819546, "Orgasmic sensation decreased ": 6.024203529332313, "Oromandibular dystonia ": 2.2883546138442954, "Oropharyngeal scar ": 3.615082672656949, "Oropharyngeal swelling ": 2.781564216239956, "Oropharyngitis fungal ": 2.516331049844454, "Orthosis user ": 4.497846157096005, "Orthostatic hypotension ": 2.635128342332101, "Osmolar gap abnormal ": 4.843626274582155, "Osmotic demyelination syndrome ": 3.1376920967560387, "Osteochondritis ": 2.441393592880345, "Otitis media chronic ": 2.017758176683172, "Otospondylomegaepiphyseal dysplasia ": 4.79129469592632, "Ototoxicity ": 2.523492912438566, "Ovarian cancer ": 3.063226128238768, "Ovarian cancer metastatic ": 2.2687650005360758, "Ovarian rupture ": 3.540905648144215, "Overdose ": 4.267992161622221, "Oxalosis ": 2.182707492679382, "Oxygen consumption ": 2.9024745245448345, "Oxygen therapy ": 2.335389151187984, "PCO2 decreased ": 2.8697248265443647, "PO2 decreased ": 2.314794342296027, "Packaging design issue ": 2.5460556445726743, "Paget's disease of nipple ": 2.2450342229325893, "Painful ejaculation ": 3.576373745791844, "Palatal oedema ": 4.290335942789303, "Palmar erythema ": 2.001855876464097, "Panic disorder ": 2.417258715672065, "Panic reaction ": 2.5282716852007785, "Pantoea agglomerans infection ": 7.99712037139817, "Papule ": 2.854510586496244, "Paradoxical pressor response ": 2.387804269380746, "Paraesthesia mucosal ": 3.0600123374239803, "Paranasal sinus injury ": 2.119843710264686, "Parathyroid gland enlargement ": 2.043655518311099, "Paravenous drug administration ": 7.510767283920724, "Parenteral nutrition associated liver disease ": 5.203844953381612, "Parkinsonian gait ": 2.2705447323482426, "Parkinsonism ": 3.218917769417358, "Parotid gland enlargement ": 2.4518449042620136, "Paroxysmal sympathetic hyperactivity ": 2.844207717923794, "Partner stress ": 3.9906472906582495, "Pasteurella infection ": 2.6974128087585774, "Patent ductus arteriosus ": 7.291347057694717, "Paternal drugs affecting foetus ": 4.826380696809855, "Patient dissatisfaction with treatment ": 2.517955561887787, "Patient elopement ": 2.155481718464486, "Patient restraint ": 2.5907254632306738, "Patient uncooperative ": 3.225583063227329, "Patient-device incompatibility ": 2.145723911501263, "Peak expiratory flow rate decreased ": 2.50781131721724, "Peak expiratory flow rate increased ": 2.848173647013041, "Pectus carinatum ": 5.992219891988702, "Pectus excavatum ": 9.99190506862145, "Pelvic haematoma ": 2.72800811588569, "Penile blister ": 2.4684870470463327, "Penile contusion ": 4.55779258879207, "Penile curvature ": 2.0617677569376225, "Penile haematoma ": 5.8435418733158135, "Penile necrosis ": 3.206012394354377, "Penile oedema ": 2.143384173871464, "Penile operation ": 2.5907254632306738, "Penile size reduced ": 10.013420854280112, "Penis disorder ": 2.064668594260769, "Penis injury ": 2.721448279980755, "Peptic ulcer ": 2.5372584319444886, "Peptic ulcer perforation ": 2.065602363262541, "Performance enhancing product use ": 2.59950973928883, "Pericarditis adhesive ": 2.992703786062721, "Periorbital irritation ": 2.158702033383775, "Periorbital oedema ": 2.712119060780732, "Peripartum cardiomyopathy ": 2.279485601685458, "Peripartum haemorrhage ": 3.0938723142390154, "Periportal sinus dilatation ": 2.7324561440655404, "Peritoneal cloudy effluent ": 23.340019202682, "Peritoneal dialysis complication ": 23.00939142604211, "Peritoneal effluent abnormal ": 7.580088704520082, "Periventricular leukomalacia ": 3.0632229490426384, "Persistent foetal circulation ": 3.9844657603791687, "Persistent generalised lymphadenopathy ": 2.8246314187502346, "Persistent left superior vena cava ": 4.680092339331298, "Personal relationship issue ": 3.4167243693843647, "Personality change ": 2.236225875340597, "Personality disorder ": 2.142239847496612, "Perthes disease ": 4.772904135896998, "Petit mal epilepsy ": 2.104007524086255, "Peyronie's disease ": 2.427217477504736, "Phaeochromocytoma ": 2.159711925015488, "Phalangeal hypoplasia ": 4.02283837449332, "Pharmaceutical nomadism ": 10.510138366415156, "Pharyngeal erythema ": 2.1324966264655565, "Pharyngeal haematoma ": 2.1589937134569936, "Pharyngeal injury ": 4.809482967964405, "Pharyngeal oedema ": 3.9569876829917208, "Pharyngeal operation ": 2.1497644818720323, "Phobia ": 2.4200536385003977, "Physical abuse ": 4.826380696809855, "Physical assault ": 2.553016376091892, "Physical disability ": 9.086383900683314, "Physical product label issue ": 2.1997009292346097, "Pica ": 3.1554650401827407, "Pickwickian syndrome ": 2.216280710420783, "Pigment dispersion syndrome ": 9.575409445861082, "Pigment nephropathy ": 2.6556073102073143, "Pigmentation disorder ": 2.123934774645688, "Pituitary apoplexy ": 3.5103262795406023, "Pituitary tumour ": 3.065592630020129, "Pituitary tumour benign ": 2.191161186509677, "Pituitary tumour recurrent ": 3.3500130170480302, "Pituitary tumour removal ": 8.825496783869223, "Plagiocephaly ": 5.973252903537125, "Plasmodium falciparum infection ": 2.321372237564148, "Plasmodium vivax infection ": 2.158702033383775, "Platelet adhesiveness decreased ": 2.119843710264686, "Pneumocephalus ": 3.7069770407614007, "Pneumoconiosis ": 3.913732912441447, "Pneumonitis aspiration ": 2.13732309411946, "Poisoning ": 4.60836816992855, "Poisoning deliberate ": 9.288618320469602, "Poland's syndrome ": 3.1548067533935624, "Polydactyly ": 3.05879853322794, "Polyhydramnios ": 2.6693936137508825, "Polyp ": 2.1031473174941286, "Poor feeding infant ": 2.351622414669142, "Poor personal hygiene ": 2.33315261325578, "Poor quality device used ": 34.589314240903875, "Poor quality product administered ": 3.2184540264612056, "Poor sucking reflex ": 3.654332297223388, "Porencephaly ": 2.039414910660589, "Poriomania ": 5.068942649117353, "Porphyria ": 2.060349732016189, "Post 5-alpha-reductase inhibitor syndrome ": 17.481807052488172, "Post embolisation syndrome ": 4.038627971753013, "Post-tussive vomiting ": 2.0464318866351654, "Postictal state ": 2.320858418961638, "Postmortem blood drug level abnormal ": 15.211422364983385, "Postmortem blood drug level increased ": 5.961318397796992, "Postnatal growth restriction ": 4.1423793880704975, "Postpartum haemorrhage ": 2.950196851229682, "Postpartum stress disorder ": 6.78597621727484, "Postural tremor ": 2.0209537743770083, "Posturing ": 2.208597383915884, "Potentiating drug interaction ": 2.746046374425543, "Potter's syndrome ": 5.148543192577682, "Poverty ": 8.009118968725161, "Poverty of speech ": 2.1142542249800265, "Precipitate labour ": 11.863951839656613, "Precocious puberty ": 2.692894283708174, "Pregnancy on oral contraceptive ": 22.529648166669475, "Premature ejaculation ": 3.8687120197152, "Premature recovery from anaesthesia ": 5.907197081000589, "Premature separation of placenta ": 2.630739988370026, "Presbyoesophagus ": 3.615082672656949, "Prescription drug used without a prescription ": 2.799558603875971, "Prescription form tampering ": 9.934545626438448, "Pressure of speech ": 2.9538777157993703, "Procedural hypotension ": 2.456730492580001, "Procedural shock ": 2.8246314187502346, "Product adhesion issue ": 11.538176703883272, "Product administration error ": 3.675016194065194, "Product after taste ": 3.88628898007962, "Product appearance confusion ": 3.2285115701860283, "Product availability issue ": 2.98729263941848, "Product blister packaging issue ": 3.046219421583188, "Product caught fire ": 5.897460791394173, "Product cleaning inadequate ": 28.410666566280582, "Product closure issue ": 3.457645315486185, "Product closure removal difficult ": 7.229322137377884, "Product coating issue ": 6.115388537611228, "Product colour issue ": 4.223533455697868, "Product commingling ": 4.655308371133672, "Product complaint ": 5.608788608018839, "Product compounding quality issue ": 4.292195308414041, "Product confusion ": 2.840853036468754, "Product container issue ": 2.215441943306689, "Product container seal issue ": 2.611291489515862, "Product contamination ": 3.4049457148235858, "Product contamination chemical ": 20.440090127758925, "Product contamination microbial ": 4.092058684049487, "Product contamination physical ": 2.362693008173615, "Product counterfeit ": 2.142719995295475, "Product delivery mechanism issue ": 9.265826238224996, "Product deposit ": 5.278284416263158, "Product design confusion ": 3.0938723142390154, "Product design issue ": 3.345147135380988, "Product dispensing error ": 3.193394836967029, "Product dispensing issue ": 2.52699458851551, "Product dosage form confusion ": 3.0915894918603004, "Product dosage form issue ": 5.551760277563229, "Product formulation issue ": 11.653632592534928, "Product impurity ": 3.906261862577389, "Product intolerance ": 2.40622094449741, "Product label confusion ": 2.2974437054956462, "Product label issue ": 2.906603184764656, "Product label on wrong product ": 6.541596807880673, "Product lot number issue ": 2.19641142827624, "Product measured potency issue ": 3.8676647592770874, "Product monitoring error ": 2.2660193473742134, "Product name confusion ": 5.092955636029015, "Product odour abnormal ": 9.43895845494856, "Product origin unknown ": 3.582119543491137, "Product outer packaging issue ": 2.3785921265590324, "Product package associated injury ": 10.502921019704605, "Product packaging confusion ": 9.487583063695, "Product packaging difficult to open ": 3.041990472461201, "Product packaging issue ": 4.237851257421613, "Product packaging quantity issue ": 2.9803549550841804, "Product physical consistency issue ": 8.677353264109586, "Product physical issue ": 2.4561054683055548, "Product preparation error ": 2.1414856755277847, "Product prescribing error ": 2.831118956680083, "Product prescribing issue ": 2.756272689832585, "Product primary packaging issue ": 8.713709740761487, "Product quality issue ": 3.5561781652399813, "Product reconstitution quality issue ": 3.20618593011718, "Product residue present ": 5.7351314234840665, "Product selection error ": 3.7263833547840566, "Product shape issue ": 4.416696116520047, "Product solubility abnormal ": 9.327814922420602, "Product substitution ": 2.807860034721575, "Product substitution issue ": 11.234851344764856, "Product supply issue ": 3.919727222365293, "Product tampering ": 3.936064980832032, "Product taste abnormal ": 14.107072374285798, "Product use complaint ": 3.784861482209704, "Product use in unapproved indication ": 2.0168569315924803, "Product with quality issue administered ": 13.829769084571922, "Progesterone decreased ": 2.242505380349595, "Progesterone increased ": 4.194235525893107, "Progesterone receptor assay positive ": 3.79363972685902, "Prognathism ": 4.636634725002985, "Prolactin-producing pituitary tumour ": 4.979405671064821, "Prolonged rupture of membranes ": 2.2796882444559303, "Prominent epicanthal folds ": 9.9526502563786, "Propofol infusion syndrome ": 12.986844603768988, "Propulsive gait ": 4.143453142560489, "Prostate cancer ": 3.162337002861423, "Prostate cancer stage I ": 2.9407983789400665, "Prostate cancer stage II ": 7.229322137377884, "Prostate cancer stage III ": 6.406470326786169, "Prostatectomy ": 2.3324848978728823, "Prostatic disorder ": 2.125424387986033, "Prostatic pain ": 2.5669362932198845, "Prostatism ": 2.041280120024456, "Prosthetic cardiac valve thrombosis ": 2.8262385602565785, "Protein C deficiency ": 2.7801871827442293, "Prothrombin level decreased ": 7.052734413838827, "Prothrombin level increased ": 3.765026251591907, "Prothrombin time abnormal ": 2.180809650515524, "Prothrombin time prolonged ": 4.14709740468815, "Prothrombin time ratio decreased ": 4.115152999235356, "Prothrombin time shortened ": 3.095984129282946, "Protrusion tongue ": 2.624762531110566, "Pseudo-Bartter syndrome ": 6.149057498512275, "Pseudocholinesterase deficiency ": 2.567861733067455, "Pseudohypoparathyroidism ": 3.615082672656949, "Pseudolymphoma ": 2.4473951292315634, "Pseudomembranous colitis ": 7.123662467324542, "Pseudomyopia ": 2.6961666124093897, "Pseudophaeochromocytoma ": 2.47292729852726, "Pseudoxanthoma elasticum ": 3.615082672656949, "Psychomotor hyperactivity ": 3.3263442136579977, "Psychomotor retardation ": 3.975188774102112, "Psychomotor skills impaired ": 3.3285856712335136, "Psychosexual disorder ": 3.500420499157024, "Pulmonary artery atresia ": 2.3332252611448574, "Pulmonary artery stenosis ": 3.4845383477500658, "Pulmonary artery stenosis congenital ": 12.782248127989488, "Pulmonary eosinophilia ": 2.4158785589986813, "Pulmonary haemorrhage neonatal ": 4.047972505381089, "Pulmonary hypoplasia ": 3.362580272432991, "Pulmonary interstitial emphysema syndrome ": 3.891465979519322, "Pulmonary malformation ": 4.064830965845844, "Pulmonary microemboli ": 2.807860034721575, "Pulmonary oil microembolism ": 34.32186596818659, "Pulmonary renal syndrome ": 4.035193906684829, "Pulmonary valve incompetence ": 2.0751911590576877, "Pulmonary valve stenosis ": 7.223069845857267, "Pulmonary valve stenosis congenital ": 13.446099804105032, "Pulse absent ": 3.2276635671726743, "Punctate keratitis ": 2.2636491077386136, "Pupil fixed ": 3.06080787153008, "Pupillary block ": 5.194688139804288, "Pupillary light reflex tests abnormal ": 3.010743156584658, "Pupillary reflex impaired ": 3.763455498770373, "Pure white cell aplasia ": 3.780429654414673, "Purple glove syndrome ": 9.072198172684706, "Purpura ": 2.433881446032224, "Pyloric stenosis ": 3.847134167320116, "Pyroglutamate increased ": 2.7324561440655404, "Pyromania ": 5.089377705412014, "QRS axis abnormal ": 2.2755002640684667, "Quadriplegia ": 2.063711060751693, "Radical mastectomy ": 2.617674630797271, "Radical prostatectomy ": 3.8062365289207896, "Radioallergosorbent test positive ": 2.119843710264686, "Rapid eye movement sleep behaviour disorder ": 2.882650336471254, "Rash maculo-papular ": 3.311379679480457, "Rash morbilliform ": 2.308287413422828, "Rash neonatal ": 3.283619010401326, "Rash papular ": 2.051002070621586, "Rash pustular ": 2.102040844081527, "Rash scarlatiniform ": 3.501729012920074, "Reaction to azo-dyes ": 3.487298748185552, "Reaction to colouring ": 3.0694156261115317, "Reaction to excipient ": 2.8184379441578296, "Reaction to sweetener ": 2.6556073102073143, "Reactive gastropathy ": 4.5426632883971685, "Reactive psychosis ": 2.739337169947462, "Reading disorder ": 2.3828843557912904, "Rebound effect ": 2.296025912237014, "Rebound nasal congestion ": 3.859879244102083, "Recalled product ": 57.33777439419582, "Recalled product administered ": 8.231041966961813, "Rectal injury ": 3.162892144732844, "Rectal polyp ": 5.378562024220134, "Regurgitation ": 2.177306174766448, "Rehabilitation therapy ": 2.01101300084213, "Renal aplasia ": 3.570964579397779, "Renal cancer ": 6.929993338556101, "Renal cancer stage I ": 2.041280120024456, "Renal cortical necrosis ": 2.0863895033321707, "Renal dysplasia ": 2.9833298514770688, "Renal failure neonatal ": 3.4946834248401237, "Renal hypoplasia ": 2.3287349339975547, "Renal impairment neonatal ": 3.500561233185535, "Renal vessel congenital anomaly ": 2.848173647013041, "Renin decreased ": 2.3042411770069817, "Renin increased ": 2.082308837258158, "Repetitive speech ": 3.1422521573791133, "Reproductive tract hypoplasia, male ": 3.442779540174401, "Residual urine volume increased ": 2.055622079171876, "Respiratory acidosis ": 3.118842580004438, "Respiratory alkalosis ": 2.2176592288517942, "Respiratory arrest ": 3.8915359153201576, "Respiratory depression ": 4.568320571719723, "Respiratory disorder neonatal ": 2.588730590460216, "Respiratory paralysis ": 7.1189753296775145, "Respiratory rate decreased ": 2.6556527511335397, "Respiratory therapy ": 5.1014313881746425, "Respiratory tract irritation ": 2.0044879529295985, "Resting tremor ": 2.0305199353929235, "Restlessness ": 2.3688837251653148, "Retained placenta or membranes ": 2.27748077074544, "Retained products of conception ": 15.331727054203268, "Retinal perivascular sheathing ": 5.2120338995345215, "Retinal pigmentation ": 2.277708364784209, "Retinogram abnormal ": 2.505632202639742, "Retinopathy of prematurity ": 2.757485007817944, "Retrognathia ": 3.850560056964408, "Retroperitoneal fibrosis ": 3.793581172214924, "Retroperitoneal haematoma ": 3.025162724547804, "Retroperitoneal haemorrhage ": 3.373220611658708, "Reversible cerebral vasoconstriction syndrome ": 2.247088394971932, "Reye's syndrome ": 2.08356463408125, "Rhabdomyolysis ": 3.246701802077788, "Rhinitis atrophic ": 2.5907254632306738, "Rhinotracheitis ": 2.5907254632306738, "Rhythm idioventricular ": 2.976063820706978, "Rickets ": 2.489100169809212, "Right aortic arch ": 7.9823439037603166, "Right ventricle outflow tract obstruction ": 3.1582598847212897, "Right ventricular hypertrophy ": 2.250110311145208, "Roseola ": 4.066377393236062, "Rubella ": 3.3960287103709885, "Rubella antibody negative ": 5.9756089375334325, "Salivary gland enlargement ": 3.7943728185512704, "Salivary gland mass ": 5.039246345822313, "Salivary hypersecretion ": 2.8299942871306256, "Scab ": 3.151428518472483, "Scaphocephaly ": 6.508249131985286, "School refusal ": 2.7089287803149595, "Scleral degeneration ": 3.615082672656949, "Scleral discolouration ": 3.058796406159473, "Scleral disorder ": 2.290718289316207, "Scleral pigmentation ": 3.390987587429732, "Scleromalacia ": 4.492837504195562, "Screaming ": 2.3745870566426714, "Scrotal disorder ": 2.539441762444792, "Scrotal haematoma ": 2.6473914494403386, "Seborrhoea ": 3.666842685011703, "Seizure ": 2.489717367346657, "Seizure anoxic ": 2.0600612252546204, "Selective eating disorder ": 2.62321703963181, "Self esteem decreased ": 3.711796527900934, "Self esteem inflated ": 3.018048574023795, "Self-destructive behaviour ": 3.301920383756484, "Self-induced vomiting ": 3.711071323108152, "Self-medication ": 4.047073104098589, "Semen analysis abnormal ": 5.518972311993257, "Semen viscosity abnormal ": 4.087854129026545, "Semen viscosity decreased ": 9.169036285391323, "Semen volume decreased ": 16.462340495407062, "Sensory integrative dysfunction ": 3.9844657603791687, "Separation anxiety disorder ": 3.79363972685902, "Septo-optic dysplasia ": 3.6909512834391984, "Septum pellucidum agenesis ": 2.946876774685152, "Serotonin syndrome ": 4.175173704204188, "Serpiginous choroiditis ": 9.224438259435836, "Serratia bacteraemia ": 5.778443613463153, "Serum serotonin decreased ": 2.0384881070613017, "Serum serotonin increased ": 2.967043443635618, "Serum sickness ": 2.8972038031510987, "Serum sickness-like reaction ": 4.630565987304372, "Sex hormone binding globulin increased ": 3.3106508746180974, "Sexual abuse ": 2.3277973666180256, "Sexual dysfunction ": 4.219860469532605, "Sexual inhibition ": 3.363071307471851, "Shared psychotic disorder ": 2.739337169947462, "Shock ": 3.461147074669838, "Shock symptom ": 4.379498629510223, "Shone complex ": 3.77657001277882, "Shoplifting ": 2.05052867485809, "Sigmoidoscopy abnormal ": 2.5907254632306738, "Similar reaction on previous exposure to drug ": 2.8503638494542263, "Single umbilical artery ": 2.4116525451543898, "Sinoatrial block ": 3.3210446427369886, "Sinus arrest ": 3.665851354021635, "Sinus bradycardia ": 3.612877904159472, "Sinus node dysfunction ": 2.2474099696486927, "Sinus tachycardia ": 2.274503916784505, "Skeletal dysplasia ": 2.0464318866351654, "Skin erosion ": 2.0997472573757374, "Skin hypoplasia ": 2.158702033383775, "Skin malformation ": 4.087854129026545, "Skin necrosis ": 3.103904254665292, "Skin oedema ": 2.025713421457311, "Skin test negative ": 14.090613018135617, "Skin test positive ": 6.845207254844766, "Skin turgor decreased ": 2.230215879687024, "Sleep attacks ": 2.018703857925951, "Sleep terror ": 3.0040748816687155, "Slow response to stimuli ": 2.992394011236041, "Small intestine carcinoma ": 3.057660323197817, "Social ": 4.864214213955248, "Social avoidant behaviour ": 2.946083142596406, "Social problem ": 4.612538747649669, "Soft tissue necrosis ": 2.2961430603263304, "Soliloquy ": 2.309302617868032, "Somnambulism ": 2.916047669671962, "Somnolence neonatal ": 5.159839539581868, "Sopor ": 4.910823340227829, "Specific gravity urine abnormal ": 3.787364818909382, "Speech disorder ": 2.0742455837524605, "Speech disorder developmental ": 7.489764164517793, "Speech sound disorder ": 3.899849023501064, "Sperm analysis abnormal ": 3.5148518229747605, "Sperm concentration decreased ": 4.944488428517633, "Sperm concentration zero ": 3.791598180341608, "Spermatocele ": 2.059807064143012, "Spermatogenesis abnormal ": 3.633047121257831, "Spermatozoa abnormal ": 3.253302696462397, "Spermatozoa progressive motility decreased ": 3.05826723229333, "Sphincter of Oddi dysfunction ": 4.571983757171695, "Spina bifida ": 9.307881668398927, "Spina bifida occulta ": 6.846316635349547, "Spinal anaesthesia ": 2.075593092528214, "Spinal claudication ": 3.0390232848659395, "Spinal cord haematoma ": 2.4124778320994578, "Spinal cord injury cauda equina ": 4.705583054188087, "Spinal cord injury lumbar ": 2.946876774685152, "Spinal cord lipoma ": 4.406448101978552, "Spinal subdural haematoma ": 2.42382439768555, "Sprue-like enteropathy ": 172.7288228115046, "Staring ": 2.293455876797243, "Stereotypy ": 2.145870014739728, "Steroid withdrawal syndrome ": 2.6015593138509443, "Stevens-Johnson syndrome ": 3.639609527367122, "Sticky skin ": 2.6900865223538863, "Stoma site erythema ": 2.59950973928883, "Stoma site inflammation ": 2.2274077408538293, "Strabismus ": 3.0740171733859394, "Strabismus congenital ": 7.878652582336181, "Strangury ": 2.094421477818836, "Strawberry tongue ": 3.312671505069676, "Stress cardiomyopathy ": 2.747675599450008, "Stridor ": 2.8247031944229346, "Stupor ": 3.724517642424073, "Subacute cutaneous lupus erythematosus ": 2.973498864588808, "Subacute sclerosing panencephalitis ": 2.5173319162917376, "Subcutaneous haematoma ": 2.3739751561721523, "Subdural haematoma evacuation ": 2.6663739977605343, "Subdural haemorrhage ": 2.301758699086143, "Subglottic laryngitis ": 2.278004847841669, "Substance abuse ": 2.946008259991852, "Substance abuser ": 10.500747080010026, "Substance dependence ": 6.331813041635209, "Substance use disorder ": 4.335625219119751, "Subvalvular aortic stenosis ": 5.545978172562894, "Sudden cardiac death ": 2.295596642627926, "Sudden onset of sleep ": 2.139047106151979, "Suffocation feeling ": 2.7355252856779115, "Suicidal behaviour ": 2.4893591276071683, "Suicidal ideation ": 2.011204755751704, "Suicide attempt ": 3.575924605264492, "Superficial injury of eye ": 2.516331049844454, "Suspected counterfeit product ": 2.195594692323787, "Suspected product contamination ": 5.293428798754087, "Suspected product quality issue ": 9.311970023165166, "Suspected suicide ": 3.307375996439719, "Suspected suicide attempt ": 3.39784936207953, "Suspected transmission of an infectious agent via product ": 2.720852107062384, "Suture insertion ": 2.192150282390372, "Swollen tongue ": 2.116307865719181, "Symmetrical drug-related intertriginous and flexural exanthema ": 3.3492101612946694, "Sympathomimetic effect ": 2.8576095853763683, "Symptom masked ": 2.1328766063100795, "Syndactyly ": 3.971983335530452, "Synostosis ": 2.792889305099717, "Synovial fluid white blood cells positive ": 7.228054958425599, "Systemic bacterial infection ": 2.119843710264686, "Systolic hypertension ": 2.8035285066803484, "Tachycardia foetal ": 3.427714936082394, "Tachycardia induced cardiomyopathy ": 3.5657892944655663, "Tachyphrenia ": 2.043534684895, "Tachypnoea ": 2.183055231535856, "Talipes ": 7.1162154846721055, "Tardive dyskinesia ": 2.524078419549817, "Tear discolouration ": 2.8888362465479496, "Tendon discomfort ": 3.68882999456238, "Tendon disorder ": 3.0010830691566244, "Tendon injury ": 7.488684495059885, "Tendon pain ": 3.381198426861797, "Tendon rupture ": 6.527613565727274, "Tendonitis ": 3.0915212672759, "Tension ": 2.37480451898001, "Teratospermia ": 2.704189143603206, "Terminal dribbling ": 6.404820898709732, "Testicular atrophy ": 4.189697507565455, "Testicular disorder ": 2.312823035789437, "Testicular failure ": 17.602001417614215, "Testicular pain ": 2.120929254609536, "Testis cancer ": 8.981949558503054, "Tetany ": 2.038096788667631, "Tethered cord syndrome ": 3.477477905696565, "Tethered oral tissue ": 2.5071816331976864, "Theft ": 2.3324848978728823, "Therapeutic drug monitoring analysis not performed ": 2.9100638210069447, "Therapeutic procedure ": 2.3007614168979083, "Therapeutic product effect increased ": 3.841837828361753, "Therapeutic product effect prolonged ": 4.393233777036584, "Therapeutic product ineffective for unapproved indication ": 2.301578549087566, "Therapeutic response changed ": 3.6945677666643375, "Therapeutic response increased ": 9.812603943749654, "Therapeutic response prolonged ": 5.026191923702681, "Therapeutic response unexpected ": 2.3918530538253098, "Thermometry abnormal ": 2.2142953271576955, "Thinking abnormal ": 2.037845156948818, "Third stage postpartum haemorrhage ": 2.0925266228089137, "Thought insertion ": 2.2450342229325893, "Throat cancer ": 3.4907187593180984, "Throat irritation ": 2.9079386216640515, "Thrombocytopenia neonatal ": 2.470150612661808, "Thrombocytopenic purpura ": 2.431601503245219, "Thyroid cancer ": 2.2317902343306857, "Thyroxine free decreased ": 2.504065261972996, "Thyroxine free increased ": 2.4888548247948585, "Thyroxine increased ": 2.1099780843773632, "Tic ": 3.3677228096086265, "Tobacco abuse ": 2.7522659942779586, "Tobacco poisoning ": 8.447912192520246, "Tobacco user ": 2.327324288687125, "Toe walking ": 4.272651510480063, "Tongue biting ": 2.5666048382896545, "Tongue coated ": 2.1275600443488623, "Tongue discolouration ": 5.391392431656931, "Tongue discomfort ": 2.538590796726074, "Tongue erythema ": 2.5098855509792592, "Tongue movement disturbance ": 2.307371102598474, "Tongue oedema ": 5.380345900740148, "Tongue pruritus ": 2.43261197163443, "Tonic clonic movements ": 2.0781264415650127, "Tonic convulsion ": 2.164932575284262, "Tooth agenesis ": 2.8785313480536923, "Tooth discolouration ": 10.29028265868072, "Tooth erosion ": 2.5039820032289364, "Topical steroid withdrawal reaction ": 4.724399646158816, "Torsade de pointes ": 6.399700596818088, "Total cholesterol/HDL ratio abnormal ": 3.615082672656949, "Tourette's disorder ": 3.597453321039998, "Toxic anterior segment syndrome ": 7.2211412869379314, "Toxic encephalopathy ": 6.172087907267465, "Toxic epidermal necrolysis ": 3.2390010841499235, "Toxic shock syndrome ": 2.291196524396278, "Toxic skin eruption ": 2.766928412793941, "Toxicity to various agents ": 4.170444836927049, "Toxicologic test abnormal ": 5.890579729766149, "Tracheal calcification ": 6.8031563798956105, "Tracheal obstruction ": 2.329282992563667, "Tracheal oedema ": 3.3437678202669416, "Tracheobronchitis bacterial ": 2.992703786062721, "Transferrin saturation decreased ": 2.2160764821872454, "Transmission of an infectious agent via product ": 4.610415708640639, "Transposition of the great vessels ": 5.140278249338905, "Transurethral resection syndrome ": 3.615082672656949, "Traumatic delivery ": 3.442779540174401, "Tremor neonatal ": 2.256157837439806, "Tri-iodothyronine free increased ": 2.169514759494804, "Tri-iodothyronine increased ": 2.68425082437952, "Trichoglossia ": 4.189697507565455, "Trichotillomania ": 2.562270527944284, "Trismus ": 2.6259034489140234, "Trousseau's sign ": 2.4172669215511355, "Truncus arteriosus persistent ": 2.4448318395062865, "Tryptase ": 7.510767283920724, "Tryptase decreased ": 7.461888341814831, "Tryptase increased ": 6.075504310740033, "Tuberculoma of central nervous system ": 2.445925557607906, "Tubulointerstitial nephritis ": 2.317117871052144, "Tympanoplasty ": 2.2142953271576955, "Type 1 lepra reaction ": 2.040534036553507, "Type 2 lepra reaction ": 2.1971999613674265, "Type I hypersensitivity ": 4.3693709790579325, "Type II hypersensitivity ": 3.891465979519322, "Type IV hypersensitivity reaction ": 3.279767481563943, "Ulcerated haemangioma ": 2.0925266228089137, "Umbilical hernia ": 2.0762885789851726, "Univentricular heart ": 2.3437301815919573, "Unmasking of previously unidentified disease ": 2.0204132437341378, "Unresponsive to stimuli ": 2.277073976066646, "Unwanted awareness during anaesthesia ": 2.735554988190805, "Upper respiratory tract irritation ": 2.277577993366569, "Urinary bladder suspension ": 2.1476805008371294, "Urinary casts ": 2.070447818919116, "Urinary hesitation ": 2.499815077900107, "Urinary retention ": 2.3085393354672585, "Urinary tract malformation ": 2.831712131471681, "Urine amphetamine positive ": 2.6961666124093897, "Urine bilirubin increased ": 2.1447791014765603, "Urine calcium decreased ": 3.601654780680706, "Urine chloride increased ": 3.487298748185552, "Urine flow decreased ": 2.85677048486426, "Urine osmolarity decreased ": 6.360958639031157, "Urine osmolarity increased ": 3.0570289746099717, "Urine output decreased ": 2.1201246865652403, "Urine potassium increased ": 2.224121452268076, "Urine sodium decreased ": 2.741472777367305, "Urine sodium increased ": 2.774053073866298, "Urticaria ": 2.14855599175597, "Urticaria papular ": 2.3526150684378715, "Uterine atony ": 2.790604720356131, "Uterine cancer ": 4.87186599063252, "Uterine dilation and curettage ": 7.563127125586946, "Uterine hyperstimulation ": 11.009382794528372, "Uterine hypertonus ": 3.635287123047323, "Uterine perforation ": 3.859879244102083, "Uterine rupture ": 9.571607644547427, "VACTERL syndrome ": 3.206012394354377, "Vaccine virus shedding ": 2.8576095853763683, "Vacuum extractor delivery ": 4.9387811580724525, "Vancomycin infusion reaction ": 14.45352933436712, "Varicella ": 13.544004575954627, "Varicella post vaccine ": 44.486327721891634, "Varicella virus test negative ": 2.182707492679382, "Varicocele ": 2.5955461117514167, "Vascular purpura ": 3.8833284020138654, "Vascular resistance systemic increased ": 4.793129411962667, "Vascular stent occlusion ": 2.599098033268341, "Vasculitis necrotising ": 2.2058289165384624, "Vasectomy ": 2.431575004969513, "Vasoconstriction ": 3.4671505055448164, "Vasodilation procedure ": 2.0563873272694297, "Vasoplegia syndrome ": 3.1979124410438864, "Vasospasm ": 2.9213072083710547, "Velopharyngeal incompetence ": 4.147715741662421, "Ventricular arrhythmia ": 3.091036117831784, "Ventricular asystole ": 2.253084019419624, "Ventricular fibrillation ": 3.1121852684431253, "Ventricular flutter ": 3.913732912441447, "Ventricular hypertrophy ": 2.1462261752809484, "Ventricular hypoplasia ": 2.413910384021141, "Ventricular septal defect ": 5.98437748005421, "Ventricular tachyarrhythmia ": 2.0411844031868918, "Ventricular tachycardia ": 3.2956698300438942, "Vesicoureteric reflux ": 2.2990917653458, "Vessel puncture site inflammation ": 5.76590816283194, "Vessel puncture site pain ": 2.182707492679382, "Victim of chemical submission ": 10.942081740626808, "Victim of homicide ": 3.875373024164392, "Victim of sexual abuse ": 4.329886383123141, "Violence-related symptom ": 2.289713277701801, "Visceral congestion ": 2.203448711752774, "Visceral oedema ": 2.792889305099717, "Visual acuity reduced transiently ": 2.5818766842578027, "Visual perseveration ": 3.3530131450886724, "Visual tracking test abnormal ": 2.8888362465479496, "Visuospatial deficit ": 6.133797719085272, "Vital dye staining cornea present ": 3.615082672656949, "Vitamin B1 decreased ": 2.218024882384535, "Vitamin B6 increased ": 2.397730974771322, "Vitamin K decreased ": 2.4674108568917084, "Vitamin K deficiency ": 6.946393816732602, "Vitello-intestinal duct remnant ": 2.2503218089250407, "Von Willebrand's factor antibody positive ": 7.0424728888252455, "Von Willebrand's factor inhibition ": 14.07430130606686, "Vulval oedema ": 2.527309505797336, "Vulvovaginal burning sensation ": 4.543923025530843, "Vulvovaginal discomfort ": 3.707920699882663, "Vulvovaginal dryness ": 2.716524636869612, "Vulvovaginal erythema ": 3.952273887291944, "Vulvovaginal exfoliation ": 10.08921392241555, "Vulvovaginal injury ": 4.905367865470461, "Vulvovaginal pain ": 2.0586039416863424, "Vulvovaginal pruritus ": 2.211223070873932, "Vulvovaginal rash ": 2.8927176922238345, "Vulvovaginal swelling ": 2.538092675704668, "Water intoxication ": 4.783466251645664, "Waxy flexibility ": 2.3344495938692265, "Weight decrease neonatal ": 2.0895536841468973, "Withdrawal arrhythmia ": 4.406448101978552, "Withdrawal bleed ": 3.082193078384861, "Withdrawal hypertension ": 2.277577993366569, "Withdrawal syndrome ": 5.768568903432912, "Wrong dosage form ": 4.826380696809855, "Wrong dose ": 3.1468294319621517, "Wrong drug ": 4.908255043006962, "Wrong patient received product ": 2.5538815374624657, "Wrong rate ": 10.099760554073583, "Wrong schedule ": 2.596795586362377, "Wrong strength ": 4.836185055698578, "Wrong technique in device usage process ": 2.617717026796781, "Wrong technique in product usage process ": 2.3016747022859603, "Yellow fever ": 3.444647014378324, "Yellow fever vaccine-associated neurotropic disease ": 28.122271498465786, "Yellow fever vaccine-associated viscerotropic disease ": 8.67536490504203} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/122.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/122.json new file mode 100644 index 00000000000..a2239e0120b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/122.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 60.71043296661498, "Acute myocardial infarction ": 23.618047233122965, "Acute pulmonary oedema ": 5.511566529707905, "Amnesia ": 2.891006817442729, "Angina pectoris ": 12.503593489808305, "Angina unstable ": 100.22710915779828, "Angioplasty ": 45.84325643231059, "Aortic stenosis ": 10.85419364374887, "Arrhythmia ": 2.763557013166295, "Arterial occlusive disease ": 18.58232363788637, "Arteriosclerosis ": 44.49856676448125, "Arteriosclerosis coronary artery ": 51.45619721533965, "Atrial fibrillation ": 10.241911629514291, "Atrial flutter ": 11.752151480888234, "Atrioventricular block ": 4.80374648200177, "Atrioventricular block complete ": 7.415844798664104, "Blindness ": 4.482629514624176, "Cardiac arrest ": 5.140590329875609, "Cardiac disorder ": 28.943638573777896, "Cardiac failure ": 3.788807156553192, "Cardiac failure congestive ": 104.4619512017606, "Cardiac operation ": 14.58077631782412, "Cardiac pacemaker insertion ": 19.937834517446312, "Cardiac valve disease ": 11.853169181862691, "Cardiac ventricular thrombosis ": 11.341652948128472, "Cardio-respiratory arrest ": 3.392282987161156, "Cardiogenic shock ": 5.5947484536308805, "Cardiomegaly ": 11.894069204386057, "Cardiomyopathy ": 33.29832491463044, "Cardiovascular disorder ": 34.3377536578613, "Carotid artery disease ": 34.88417120150129, "Catheterisation cardiac ": 21.67903078095096, "Cerebral infarction ": 2.357329880691526, "Cerebrovascular accident ": 22.683160374407223, "Cerebrovascular disorder ": 21.709715064212386, "Chest pain ": 2.9880563191681166, "Chronic obstructive pulmonary disease ": 2.151260034691944, "Coronary arterial stent insertion ": 55.372997306132895, "Coronary artery bypass ": 116.1391656005156, "Coronary artery disease ": 169.08569785564652, "Coronary artery occlusion ": 16.115326487772382, "Coronary artery stenosis ": 8.483288827221196, "Diabetic retinopathy ": 6.479268986983397, "Dilated cardiomyopathy ": 21.715518874769412, "Fluid retention ": 4.868525016089837, "Heart rate irregular ": 5.271241572513962, "Hemiparesis ": 3.0169948322825304, "Hemiplegia ": 2.893038001513855, "Hyperlipidaemia ": 15.304757636588963, "Hypertension ": 2.128176983403482, "Hypertensive heart disease ": 27.68616959106914, "Implantable defibrillator insertion ": 72.10628156499364, "Injury ": 6.082735841414787, "Ischaemia ": 10.738798988022532, "Ischaemic cardiomyopathy ": 169.05160863372032, "Ischaemic stroke ": 2.4155015201814027, "Lacunar infarction ": 11.344734333160911, "Left ventricular dysfunction ": 5.097039210258387, "Macular oedema ": 26.75152210463802, "Mitral valve incompetence ": 8.707804642688046, "Myocardial infarction ": 63.61789877734254, "Myocardial injury ": 147.73120757729404, "Myocardial ischaemia ": 105.0980192728626, "Oedema ": 2.3627474756270748, "Pericardial effusion ": 3.9064900829692415, "Peripheral vascular disorder ": 5.234960823364357, "Pleural effusion ": 5.824423803126988, "Pulmonary hypertension ": 4.95285884304413, "Pulmonary oedema ": 7.574492324585017, "Silent myocardial infarction ": 133.53069705627797, "Sinus node dysfunction ": 23.844714122606327, "Stent placement ": 73.18778338968191, "Sudden cardiac death ": 12.478341212113836, "Supraventricular tachycardia ": 9.139617413033282, "Transient ischaemic attack ": 23.62075395691535, "Ventricular fibrillation ": 4.765279158410529, "Ventricular tachycardia ": 7.567434640734304} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/123.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/123.json new file mode 100644 index 00000000000..b722b2752b1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/123.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 38.27116578786335, "Acute myocardial infarction ": 21.50512379412397, "Acute pulmonary oedema ": 6.5843825648219205, "Acute respiratory failure ": 2.3903323532447263, "Alanine aminotransferase increased ": 2.0078399660957147, "Amnesia ": 2.463285906066578, "Aneurysm ": 3.6539815259801465, "Angina pectoris ": 10.07954079592127, "Angina unstable ": 77.83761588051956, "Angiopathy ": 4.333558304004541, "Angioplasty ": 25.75840700252757, "Aortic aneurysm ": 2.5261139334429763, "Aortic arteriosclerosis ": 5.367409323557069, "Aortic stenosis ": 17.233442658468967, "Aortic valve disease ": 7.269905223714561, "Aortic valve incompetence ": 4.580170668540155, "Aortic valve replacement ": 18.602610553937968, "Aortic valve stenosis ": 10.39883154122372, "Arrhythmia ": 3.3864220168075776, "Arterial disorder ": 7.327198674532172, "Arterial occlusive disease ": 12.997503544288795, "Arterial stenosis ": 6.678563257384186, "Arteriosclerosis ": 29.9932414377477, "Arteriosclerosis coronary artery ": 40.77317616096587, "Aspartate aminotransferase increased ": 2.002514034589882, "Atrial fibrillation ": 10.33862560469207, "Atrial flutter ": 13.00861855186044, "Atrioventricular block ": 6.017028078682692, "Atrioventricular block complete ": 6.509628127960115, "Atrioventricular block first degree ": 4.489160933955906, "Atrioventricular block second degree ": 5.728504500486245, "Blindness ": 3.3290183326233627, "Blood alkaline phosphatase increased ": 2.3835883387006183, "Blood bilirubin increased ": 2.208542461144458, "Blood triglycerides increased ": 2.735051850598865, "Brain injury ": 3.917724158352318, "Brain stem infarction ": 11.845639041941055, "Brain stem stroke ": 9.931168679544324, "Bundle branch block ": 4.871043275993024, "Bundle branch block left ": 5.154379714731715, "Bundle branch block right ": 5.488581106330056, "Cardiac arrest ": 6.976068509320149, "Cardiac assistance device user ": 123.18733186227288, "Cardiac death ": 13.037123620844204, "Cardiac disorder ": 27.684924740229363, "Cardiac failure ": 7.0215774819115175, "Cardiac failure chronic ": 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13.309273364352492, "Chest pain ": 2.3082807721063108, "Chronic obstructive pulmonary disease ": 2.211175090819899, "Cor pulmonale ": 24.225855822519204, "Coronary angioplasty ": 22.041970804782157, "Coronary arterial stent insertion ": 44.21262373050259, "Coronary artery bypass ": 118.96077847315031, "Coronary artery disease ": 179.02602553093664, "Coronary artery occlusion ": 16.685233151392737, "Coronary artery stenosis ": 5.277059551346465, "Coronary artery thrombosis ": 4.819469542878076, "Death ": 4.279523755190527, "Diabetic complication ": 3.221978887693275, "Diabetic retinopathy ": 5.475881645653248, "Diastolic dysfunction ": 10.627815105201469, "Dilated cardiomyopathy ": 24.4372415832342, "Disability ": 2.575245743437605, "Dyspnoea paroxysmal nocturnal ": 8.603117149973123, "Ejection fraction decreased ": 2.3196035920313878, "Electrocardiogram change ": 4.942959132239823, "Embolic stroke ": 3.4631106045619933, "End stage renal disease ": 2.847829702820295, "Fluid retention ": 7.802737628966721, "Fracture ": 2.406422488438323, "Generalised oedema ": 3.16527752348487, "Heart rate irregular ": 6.273238005579436, "Heart sounds abnormal ": 5.662628944136256, "Heart valve incompetence ": 7.480437648802755, "Heart valve replacement ": 8.088474615620378, "Hemiparesis ": 3.3782616450182954, "Hemiplegia ": 2.6499985934902237, "Hepatic cirrhosis ": 2.595557005903756, "Hepatic failure ": 3.236832711774552, "Hepatic necrosis ": 3.435162665874572, "High density lipoprotein decreased ": 5.018453519998397, "Humerus fracture ": 2.492301123866433, "Hyperlipidaemia ": 10.894237758081053, "Hypertensive cardiomyopathy ": 28.971509755519406, "Hypertensive heart disease ": 30.99793316451888, "Hypertrophic cardiomyopathy ": 3.912040721943266, "Hypervolaemia ": 6.426760338457346, "Hypoxic-ischaemic encephalopathy ": 11.517689810883622, "Implantable defibrillator insertion ": 67.76721455366767, "Injury ": 12.57712977984629, "Ischaemia ": 11.298375858973191, "Ischaemic cardiomyopathy ": 234.05620985013016, "Ischaemic stroke ": 3.742709476090834, "Jugular vein distension ": 9.058979089733969, "Lacunar infarction ": 16.58420049389253, "Left atrial enlargement ": 11.297753703386013, "Left ventricular dysfunction ": 6.683133943722663, "Left ventricular failure ": 6.345851504312924, "Left ventricular hypertrophy ": 7.09938559562857, "Leg amputation ": 4.68164557239068, "Macular oedema ": 50.570604294264726, "Mitral valve disease ": 15.396607845184848, "Mitral valve incompetence ": 9.88420787721383, "Mitral valve prolapse ": 5.6126197414567605, "Myocardial infarction ": 65.88708404164942, "Myocardial injury ": 181.7509825862903, "Myocardial ischaemia ": 75.73261401072858, "Obstruction ": 7.250883023933782, "Oedema ": 5.649473610403978, "Oedema peripheral ": 3.0749932058921328, "Orthopnoea ": 11.616204282460613, "Oxygen therapy ": 8.30495392094646, "Percutaneous coronary intervention ": 30.486712478463133, "Pericardial effusion ": 5.3884355503676105, "Peripheral arterial occlusive disease ": 3.595742729762115, "Peripheral vascular disorder ": 6.756682927408639, "Pleural effusion ": 7.120059347451, "Pulmonary hypertension ": 7.998518804061009, "Pulmonary oedema ": 10.488578994774208, "Renal artery stenosis ": 3.5803294054449943, "Renal failure ": 2.0501693966716874, "Respiratory failure ": 3.0820235222524754, "Silent myocardial infarction ": 101.08552263729445, "Sinus node dysfunction ": 22.91092917009161, "Stent placement ": 76.16923964738442, "Sudden cardiac death ": 16.255661799610106, "Supraventricular tachycardia ": 7.62513411611777, "Systolic dysfunction ": 4.647644783279799, "Toe amputation ": 2.205213782983147, "Transient ischaemic attack ": 22.866042068495744, "Traumatic lung injury ": 5.651198721492126, "Tricuspid valve incompetence ": 4.319504011342207, "Vascular graft ": 48.133238740483016, "Vascular occlusion ": 2.842262095458905, "Ventricular arrhythmia ": 4.790327141951398, "Ventricular fibrillation ": 6.730305156216914, "Ventricular hypertrophy ": 4.085527961301992, "Ventricular tachycardia ": 7.049131529894732, "Weight increased ": 4.012559569934552} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/124.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/124.json new file mode 100644 index 00000000000..f5ed35a56ef --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/124.json @@ -0,0 +1 @@ +{"Cardiotoxicity ": 288.3915723392538, "Disease progression ": 15.402339030639132, "Drug resistance ": 85.13210303001547, "Face oedema ": 43.97098945438533, "Hypersensitivity ": 17.854230528222327, "Multiple-drug resistance ": 221.49405833462865} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/125.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/125.json new file mode 100644 index 00000000000..b54165d7247 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/125.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 9.172792028809967, "Abdominal pain lower ": 2.0875308007656788, "Abscess ": 2.725261632807709, "Acute myeloid leukaemia ": 3.104121818912148, "Anaemia ": 2.283798329725504, "Anal fistula ": 14.96573745781695, "Anaphylactoid reaction ": 5.713601580506567, "Aortic dissection ": 7.369900695043835, "Ascites ": 3.7675203174012375, "Astrocytoma ": 32.01138660729955, "Blindness ": 2.172725269532234, "Blindness transient ": 2.874154525701481, "Blindness unilateral ": 3.184626907555024, "Brain oedema ": 3.706183331683051, "Breast cancer metastatic ": 2.0348898292989803, "Cachexia ": 2.748447505008456, "Carbohydrate antigen 125 increased ": 10.372302789020672, "Carcinoembryonic antigen increased ": 18.898545224348137, "Cardiac failure ": 2.738780887016666, "Cardiomyopathy ": 2.681714525286883, "Cardiotoxicity ": 2.460869654027173, "Cerebral haemorrhage ": 2.296034218601947, "Cerebral infarction ": 3.999783308337639, "Cerebral ischaemia ": 3.78920540299282, "Cholecystitis acute ": 3.767793974396821, "Cholestasis ": 2.1616983788964, "Colitis ischaemic ": 3.261794753444086, "Colon cancer ": 4.297730030012303, "Colon cancer metastatic ": 45.76264673786483, "Colorectal cancer metastatic ": 35.99606509494143, "Constipation ": 2.2389320076574117, "Cytopenia ": 2.9195586738534662, "Decreased appetite ": 2.619136987014389, "Deep vein thrombosis ": 3.380159359957968, "Dehydration ": 2.584103758227644, "Dermatitis acneiform ": 3.6640948258434687, "Detachment of retinal pigment epithelium ": 18.024381748471328, "Device related infection ": 4.940960810797854, "Device related thrombosis ": 19.51913886594531, "Diarrhoea ": 2.6271439529554184, "Disease progression ": 28.22371270782651, "Disseminated intravascular coagulation ": 8.82674543453865, "Diverticular perforation ": 8.203165485461634, "Duodenal perforation ": 34.62008105327172, "Duodenal ulcer ": 3.3403461977729365, "Duodenal ulcer haemorrhage ": 5.8394109725486905, "Dyslalia ": 8.456253274498467, "Ejection fraction decreased ": 4.054034430740322, "Embolism ": 5.611722486720088, "Embolism venous ": 12.98147081650123, "Endophthalmitis ": 4.775386871321967, "Enteritis ": 4.352757073786924, "Enterocolitis ": 5.799014917436428, "Enterocutaneous fistula ": 67.85565016741296, "Epistaxis ": 3.32755121769311, "Eye inflammation ": 2.4011158012173035, "Faeces soft ": 4.149022194990533, "Febrile neutropenia ": 6.021737715764351, "Female genital tract fistula ": 6.288492714169968, "Fistula ": 14.77510698005488, "Fournier's gangrene ": 4.595623332618251, "Gastric haemorrhage ": 2.5488917458702662, "Gastric perforation ": 30.30503464692183, "Gastric ulcer ": 5.4807383798835305, "Gastric ulcer haemorrhage ": 3.934102210524969, "Gastrointestinal necrosis ": 10.786525829714742, "Gastrointestinal perforation ": 94.09625524929132, "Gastrointestinal toxicity ": 12.099988537573765, "Granulocyte 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"Jugular vein thrombosis ": 9.749576248004312, "KL-6 increased ": 12.268590074793543, "Large intestine perforation ": 43.322128058452186, "Left ventricular dysfunction ": 3.7269477565575433, "Leukoencephalopathy ": 8.278959534084095, "Leukopenia ": 2.7890573125360465, "Liver abscess ": 5.37008012130089, "Lymphangiosis carcinomatosa ": 16.17035983169931, "Macular oedema ": 5.276359869718402, "Malignant neoplasm progression ": 4.947617691044979, "Melaena ": 2.069628089556249, "Metastases to bone ": 4.2378201426009, "Metastases to central nervous system ": 5.874240879541268, "Metastases to liver ": 7.939289503185602, "Metastases to lung ": 9.557683838820886, "Metastases to lymph nodes ": 6.847831531591747, "Metastases to pelvis ": 19.490208918049344, "Metastases to peritoneum ": 8.460768537383478, "Metastasis ": 5.908860087813162, "Metastatic neoplasm ": 5.685191986693974, "Mucosal disorder ": 3.602166329713131, "Mucosal inflammation ": 5.809776800295488, "Myelosuppression ": 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"Polyneuropathy ": 2.167719653710725, "Portal hypertension ": 11.640929385326508, "Portal vein thrombosis ": 7.608930707820455, "Posterior reversible encephalopathy syndrome ": 8.302118346397739, "Proctalgia ": 2.5874098425158985, "Protein urine ": 26.45948413838928, "Protein urine present ": 7.267891011873724, "Proteinuria ": 14.67991337313445, "Pulmonary artery thrombosis ": 20.34702691297952, "Pulmonary embolism ": 4.438492024092371, "Pulmonary haemorrhage ": 2.3209362428387066, "Rectal cancer ": 8.746797235302799, "Rectal cancer metastatic ": 51.48815223798599, "Rectal haemorrhage ": 4.698186352390009, "Rectal perforation ": 183.126423917505, "Red cell distribution width increased ": 3.812224159576691, "Retinal artery occlusion ": 3.3459176383378346, "Retinal haemorrhage ": 2.7356853705294304, "Retinal oedema ": 10.193139501189185, "Retinal vascular occlusion ": 9.221081610538429, "Sepsis ": 2.6183742526814937, "Septic shock ": 2.023682539787245, "Shock ": 3.069680801595763, "Shock 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liver disease ": 2.771774006924689, "Venous thrombosis ": 10.272739588740585, "Venous thrombosis limb ": 6.516523192323351, "Ventricular hypertrophy ": 8.9608551125142, "Visual acuity reduced ": 3.7106504056524, "Vitreous detachment ": 6.367057047321531, "Vitreous floaters ": 4.067409674789608, "Vitritis ": 3.25714043731804, "White blood cell count decreased ": 6.900969549396407, "Wound dehiscence ": 15.963747807507271, "Wound infection ": 7.606822867032728} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/126.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/126.json new file mode 100644 index 00000000000..5c142074963 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/126.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 3.945711070899304, "Aphthous ulcer ": 8.374486553079608, "Arthritis ": 4.3810188036593765, "Aspartate aminotransferase increased ": 2.667095024285793, "Death ": 2.099160638053909, "Dehydration ": 2.1440375839233727, "Diarrhoea ": 4.0359957295032665, "Disease progression ": 24.667426889164616, "Dysphonia ": 12.464257655064747, "Febrile neutropenia ": 7.9766715281757135, "General physical health deterioration ": 3.742244031194057, "Haematuria ": 2.679155157518853, "Hepatitis ": 5.186145496372268, "Hypertension ": 6.896219057994264, "Hyperthyroidism ": 17.66081019452021, "Hypertransaminasaemia ": 12.68088634569746, "Hypokalaemia ": 2.020972390119396, "Hypothyroidism ": 30.30551508517025, "Immune-mediated hepatitis ": 55.05827703969306, "Infusion related reaction ": 16.322856595610713, "Mucosal inflammation ": 11.506867451942869, "Myocarditis ": 6.266588365811183, "Myositis ": 14.199936351905746, "Neoplasm progression ": 34.31551260473867, "Off label use ": 4.255352582443684, "Palmar-plantar erythrodysaesthesia syndrome ": 4.649060618661651, "Pneumonitis ": 8.365874232351949, "Stomatitis ": 2.1646869755117897, "Transaminases increased ": 2.92623304726028} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/127.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/127.json new file mode 100644 index 00000000000..a97c7fc988b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/127.json @@ -0,0 +1 @@ +{"Adverse drug reaction ": 5.846551572097564, "Breast cancer ": 3.217422058519721, "Carpal tunnel syndrome ": 18.056008123809608, "Chronic kidney disease ": 3.082942409234644, "Congenital aortic anomaly ": 717.2370049754162, "Depression ": 3.461567957069028, "Diabetic neuropathy ": 38.56803408252614, "Encephalitis autoimmune ": 80.16806606228965, "Exposure during pregnancy ": 2.0113939867838555, "Fall ": 2.2505888632388173, "Fibromyalgia ": 6.382653422141187, "Gait disturbance ": 3.953901283039694, "Haemorrhoids ": 8.808383760899382, "Hyperlipidaemia ": 14.811015150856756, "Hypothyroidism ": 3.589389630015726, "Illness ": 2.199414154102292, "Implant site swelling ": 765.3409833463292, "Influenza like illness ": 2.308208306179784, "Intrathecal pump insertion ": 2860.8734320198582, "Medical device removal ": 612.9718071700232, "Medical device site infection ": 1110.911552596269, "Memory impairment ": 3.118720419413033, "Mitral valve prolapse ": 138.07514204204986, "Multiple sclerosis ": 55.70613096320757, "Multiple sclerosis relapse ": 52.38570504027653, "Muscle spasticity ": 47.86737051065053, "Muscular weakness ": 2.556692857144089, "Neuropathy peripheral ": 5.331845499672351, "Osteoarthritis ": 5.473311161671718, "Pancreatitis ": 2.7493343494663707, "Peptic ulcer ": 55.63652702114012, "Psoriasis ": 3.651217352739838, "Rhabdomyolysis ": 3.440910591764494, "Sleep apnoea syndrome ": 19.10013005312653, "Staphylococcal infection ": 23.59299833629277, "Stress ": 5.874309791535641, "Therapy non-responder ": 6.185364191619148, "Urinary tract infection ": 2.528806725828647} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/128.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/128.json new file mode 100644 index 00000000000..6bdf179e0cf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/128.json @@ -0,0 +1 @@ +{"Bronchopulmonary aspergillosis ": 37.950786354948434, "Cardiac tamponade ": 47.35308898612319, "Cellulitis ": 6.827100509368127, "Cytokine release syndrome ": 532.035408602709, "Cytokine storm ": 207.16301814372397, "Cytopenia ": 23.79181085440169, "Diffuse large B-cell lymphoma ": 56.71476246147901, "Disease progression ": 15.504676526452686, "Encephalopathy ": 20.69605486978968, "Febrile neutropenia ": 7.587044907758247, "Hypogammaglobulinaemia ": 81.93672085599854, "Immune effector cell-associated neurotoxicity syndrome ": 701.3511367824474, "Infection reactivation ": 230.9584636332921, "Myelodysplastic syndrome ": 21.785252719774228, "Myelosuppression ": 4.29364959033556, "Neurotoxicity ": 96.237660765208, "Neutropenia ": 7.847349187259715, "Neutrophil count decreased ": 3.941681416305357, "Off label use ": 2.2465520397093868, "Pancytopenia ": 7.408489041631926, "Platelet count decreased ": 2.123433829948547, "Septic shock ": 8.30347078718364, "Thrombocytopenia ": 4.764848267732937, "Tumour lysis syndrome ": 55.43007643811781, "White blood cell count decreased ": 2.602999876440353} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/129.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/129.json new file mode 100644 index 00000000000..86d5c5982bf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/129.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 11.393833915921212, "Adverse event ": 2.3414006515089265, "Alanine aminotransferase increased ": 5.38940663197809, "Aphthous ulcer ": 3.3673544198793226, "Aspartate aminotransferase increased ": 4.500276336044569, "Blood bilirubin increased ": 2.821920756991148, "Blood pressure increased ": 2.2695254341026607, "Blood thyroid stimulating hormone increased ": 11.253398831694664, "Cardiac dysfunction ": 17.498413234950416, "Colitis ": 3.2702718949425544, "Decreased appetite ": 2.9149107005178125, "Dehydration ": 2.3972255478731626, "Diarrhoea ": 4.926284280621987, "Disease progression ": 7.010664653476092, "Drug-induced liver injury ": 4.034734183319895, "Dysphonia ": 13.71902139933939, "Encephalitis ": 6.397276805396016, "General physical health deterioration ": 2.698083704506822, "Hepatic function abnormal ": 4.788479524448436, "Hepatitis ": 16.758122107128052, "Hepatotoxicity ": 14.272362363384111, "Hypertension ": 8.907816677691093, "Hyperthyroidism ": 6.025984053788545, "Hypertransaminasaemia ": 12.064396994877864, "Hypophagia ": 3.744226475444639, "Hypophysitis ": 17.305085328067893, "Hypopituitarism ": 34.941480539154895, "Hypothyroidism ": 27.577781786180037, "Immune-mediated adrenal insufficiency ": 31.67364996594425, "Immune-mediated enterocolitis ": 13.01830059839609, "Immune-mediated hepatic disorder ": 87.1198856764298, "Immune-mediated hepatitis ": 26.97754940870548, "Immune-mediated hyperthyroidism ": 56.16742196589801, "Immune-mediated hypothyroidism ": 75.94154727669668, "Immune-mediated myocarditis ": 46.68329156981822, "Liver disorder ": 3.3729178115512246, "Liver function test increased ": 4.287770032955797, "Liver injury ": 2.7818436503589345, "Malignant neoplasm progression ": 19.186621125061976, "Metastases to lung ": 8.412810015504931, "Metastatic renal cell carcinoma ": 15.124255365368272, "Mucosal inflammation ": 10.235257851890683, "Myasthenia gravis ": 12.11973995023847, "Myocarditis ": 2.96007335532532, "Myositis ": 9.919810495913202, "Neoplasm progression ": 23.478976029793955, "Nephritis ": 17.292789469821198, "Off label use ": 2.499145924108316, "Osteonecrosis of jaw ": 10.442535568322572, "Palmar-plantar erythrodysaesthesia syndrome ": 21.53643371209697, "Pancreatitis acute ": 2.2003738649165308, "Pneumonitis ": 5.801531428388537, "Polycythaemia ": 41.579890874547424, "Posterior reversible encephalopathy syndrome ": 15.43629919383513, "Product use in unapproved indication ": 2.499799584092084, "Proteinuria ": 10.719986954240738, "Pulmonary mass ": 3.930864957697491, "Renal cell carcinoma ": 7.949600331180702, "Skin disorder ": 2.0561812031397326, "Skin reaction ": 2.818047522677273, "Stomatitis ": 5.030058807297966, "Therapy partial responder ": 35.51013363548202, "Thyroid disorder ": 4.205265780274622, "Thyroiditis ": 18.15431951042947, "Transaminases increased ": 6.058471708250701, "Tubulointerstitial nephritis ": 6.647886705238142, "Type 1 diabetes mellitus ": 5.437023362398193, "Weight decreased ": 2.693083637418138} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/13.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/13.json new file mode 100644 index 00000000000..d67cd1c5c01 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/13.json @@ -0,0 +1 @@ +{"Abdominal pain upper ": 2.644528394223161, "Acute kidney injury ": 2.5930696006450025, "Adrenal cyst ": 3589.959076313897, "Angioedema ": 9.675285477397145, "Blood pressure increased ": 3.3731949253441567, "Completed suicide ": 9.776473580092135, "Disorientation ": 14.069035486146465, "Drug interaction ": 4.47462325957784, "Drug intolerance ": 5.28008056330669, "Feeling abnormal ": 5.182182794801889, "Gait disturbance ": 4.17521670958171, "Haemoglobin decreased ": 6.229015300163077, "Hyperkalaemia ": 7.974255272199924, "Hypertonic bladder ": 255.74431146299892, "Incontinence ": 54.16071193622556, "Macular degeneration ": 25.88607086778382, "Memory impairment ": 5.312704066005202, "Oedema peripheral ": 4.287485847828577, "Product dispensing error ": 40.20452458043525, "Renal impairment ": 4.018657817045645, "Somnolence ": 2.3274250506578853, "Toxicity to various agents ": 2.517962398323903} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/130.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/130.json new file mode 100644 index 00000000000..c778368ebbf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/130.json @@ -0,0 +1 @@ +{"Aggression ": 11.30751142083474, "Confusional state ": 3.519031613972401, "Delirium ": 16.60492679529581, "Dizziness ": 2.466106202453957, "Drug interaction ": 6.528500494655908, "Hallucination ": 8.504855877447458, "Intentional overdose ": 10.644863180880686, "Restlessness ": 15.079259359001355, "Seizure ": 2.5009817973841013, "Somnolence ": 5.9768366257736085, "Suicide attempt ": 9.169613523031614, "Syncope ": 3.516029121483036} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/131.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/131.json new file mode 100644 index 00000000000..e3c4cbb88d5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/131.json @@ -0,0 +1 @@ +{"Neutropenia ": 32.3138873188415} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/132.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/132.json new file mode 100644 index 00000000000..b23fd907980 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/132.json @@ -0,0 +1 @@ +{"Asthenia ": 11.257891559444152, "Cystitis ": 286.7213948366054, "Dialysis ": 963.4787142268171, "Haemorrhage ": 62.75145750431325, "Illness ": 63.51362596336912, "Inflammation ": 114.64005417024296, "Weight decreased ": 31.288625526700592} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/133.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/133.json new file mode 100644 index 00000000000..d82aa4ffb3d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/133.json @@ -0,0 +1 @@ +{"Hyperbilirubinaemia ": 81.21165448975894, "Off label use ": 14.337032389729025, "Periorbital oedema ": 267.8413402999365} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/134.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/134.json new file mode 100644 index 00000000000..385b208b84a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/134.json @@ -0,0 +1 @@ +{"Acute febrile neutrophilic dermatosis ": 18.82969268886989, "Acute graft versus host disease in skin ": 11.475916850729137, "Acute myeloid leukaemia ": 74.73891875752705, "Acute myeloid leukaemia recurrent ": 311.6572599101515, "Acute myeloid leukaemia refractory ": 316.805896993179, "Acute respiratory failure ": 3.998907967458603, "Agranulocytosis ": 3.956415070085957, "Anaemia ": 6.562574264637725, "Aspergillus infection ": 10.788052278201825, "Bacillus infection ": 97.91668952419596, "Bacteraemia ": 23.173383842655763, "Blast cell count increased ": 75.60746659487052, "Bone marrow disorder ": 18.209017773186428, "Bone marrow failure ": 12.053733958989952, "Bradypnoea ": 13.955491513341414, "Bronchopulmonary aspergillosis ": 9.467144769669227, "COVID-19 pneumonia ": 5.022562084400602, "Candida infection ": 4.14091601393544, "Cardiomyopathy ": 4.3059031483059576, "Chronic graft versus host disease ": 12.588829711661024, "Clostridium difficile infection ": 4.311910718609019, "Congenital aplasia ": 18.133066178684484, "Cytomegalovirus infection reactivation ": 8.56835259258077, "Cytopenia ": 60.88229519497963, "Disease progression ": 4.20052370793295, "Disease recurrence ": 3.2231194505925878, "Drug resistance ": 2.460042616203085, "Ejection fraction decreased ": 2.48437801264004, "Epstein-Barr virus infection reactivation ": 21.448494226992747, "Febrile neutropenia ": 57.72506348179317, "Full blood count decreased ": 4.470106748047323, "Fungaemia ": 27.554173674062927, "Fungal infection ": 8.866809752405775, "Gene mutation ": 22.397063404129423, "Graft versus host disease ": 7.677888281745559, "Graft versus host disease in skin ": 13.551880321876038, "Granulocyte count decreased ": 38.3197928802718, "Haematotoxicity ": 45.96069004427152, "Haemodynamic instability ": 9.609600102688969, "Haemoglobin decreased ": 2.012720730019101, "Haemophagocytic lymphohistiocytosis ": 14.078457478158864, "Hepatic failure ": 2.084752138218937, "Hyperbilirubinaemia ": 2.2584543690588026, "Infection ": 5.6438588113847, "JC virus infection ": 47.00734851353359, "Leukocytosis ": 3.7453140505611313, "Leukopenia ": 2.618180303770428, "Lung infiltration ": 3.9712134913622257, "Lymphocyte count decreased ": 4.51923658288471, "Malignant neoplasm progression ": 2.0528288742589726, "Meningitis ": 11.329537963438954, "Minimal residual disease ": 124.9021968373036, "Mucosal inflammation ": 2.2990966643045407, "Multiple organ dysfunction syndrome ": 4.130361469672551, "Myelodysplastic syndrome ": 20.665504242509662, "Myelosuppression ": 28.384324838937022, "Myocardial ischaemia ": 4.443949324395582, "Neutropenia ": 16.005021914560267, "Neutropenic colitis ": 31.263827805238563, "Neutropenic sepsis ": 38.46956013909756, "Neutrophil count decreased ": 7.995821449336806, "Off label use ": 4.278068345537489, "Pancytopenia ": 12.151355792967754, "Photophobia ": 2.110448223421736, "Platelet count decreased ": 5.2840529728928205, "Pneumocystis jirovecii pneumonia ": 4.810503632835713, "Pneumonia ": 3.904417489215523, "Pneumonia fungal ": 52.381814793976176, "Pneumonitis ": 4.512906102551736, "Pneumothorax ": 7.678725651460646, "Product use in unapproved indication ": 2.016403298573421, "Progressive multifocal leukoencephalopathy ": 16.383356634562368, "Pseudomonal bacteraemia ": 68.5374381551583, "Respiratory distress ": 2.457462934831252, "Respiratory failure ": 2.807957313353412, "Respiratory tract infection ": 2.3763094965132394, "Second primary malignancy ": 5.261337700330448, "Sepsis ": 6.071747332350092, "Septic shock ": 9.87379374040063, "Serum ferritin increased ": 13.399058781761836, "Splenomegaly ": 6.040376250849704, "Staphylococcal bacteraemia ": 21.238791734885112, "Staphylococcal sepsis ": 16.212030770111898, "Stenotrophomonas infection ": 33.18064330827153, "Systemic candida ": 26.5420189444426, "Therapeutic product effect incomplete ": 3.207622870808815, "Therapy non-responder ": 2.171243752700478, "Therapy partial responder ": 8.661754146913392, "Thrombocytopenia ": 10.112357785873856, "Tumour lysis syndrome ": 72.42978168997577, "Unevaluable event ": 2.290218840538167, "Venoocclusive liver disease ": 14.185020840545617, "White blood cell count abnormal ": 14.751921149380658, "White blood cell count decreased ": 6.574248365810278} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/135.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/135.json new file mode 100644 index 00000000000..914563d047a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/135.json @@ -0,0 +1 @@ +{"Epidermal necrosis ": 1291.3632998222286, "Haemoglobin decreased ": 42.1372592140456, "Nikolsky's sign ": 1296.5589549937945, "Off label use ": 8.40484346734086, "Rash erythematous ": 26.19745515552989, "Rash papular ": 109.99182813888548, "Toxic epidermal necrolysis ": 188.7290780133875} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/136.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/136.json new file mode 100644 index 00000000000..c3993ae68fb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/136.json @@ -0,0 +1 @@ +{"Actinic keratosis ": 18.110542398735, "Acute graft versus host disease ": 6.137959921782581, "Acute hepatic failure ": 2.640490827396351, "Alanine aminotransferase increased ": 2.0721269821970485, "Anal fissure ": 10.507514332225952, "Antineutrophil cytoplasmic antibody positive ": 46.01920140651239, "Arteriosclerosis ": 6.047843027211649, "Arteriosclerosis coronary artery ": 7.776722063299803, "Arthritis ": 2.199008872674337, "Aspergillus infection ": 4.297640527661327, "Autoscopy ": 166.45061512156218, "Bacteraemia ": 2.9763327062180025, "Basal cell carcinoma ": 5.791842799890136, "Bone erosion ": 5.750505770324966, "Bone marrow failure ": 2.81029504019246, "Bowen's disease ": 28.60412308755833, "Breath sounds abnormal ": 2.860074264859325, "Bronchopulmonary aspergillosis ": 3.188113090439413, "C-reactive protein abnormal ": 6.863650239501189, "C-reactive protein increased ": 2.307522088256549, "Candida infection ": 2.8468750057959404, "Central nervous system lesion ": 3.0411762716033883, "Cerebral atrophy ": 4.414156399113344, "Chronic allograft nephropathy ": 23.008132291208053, "Chronic gastrointestinal bleeding ": 92.54985200379114, "Chronic graft versus host disease ": 21.575669343844865, "Clear cell renal cell carcinoma ": 85.34361420446479, "Clostridium difficile infection ": 4.470428653911436, "Colitis ": 9.343537391031086, "Colitis ulcerative ": 9.732036292418076, "Concussion ": 3.740409511989313, "Condition aggravated ": 2.8368053394147976, "Conjunctivitis allergic ": 26.38942248531261, "Coombs positive haemolytic anaemia ": 76.26573182148286, "Coronary angioplasty ": 11.629214092381131, "Coronavirus infection ": 3.654108917992733, "Crohn's disease ": 11.950131938261547, "Cushingoid ": 5.45094475326935, "Cytomegalovirus chorioretinitis ": 10.984491409074597, "Cytomegalovirus colitis ": 8.75983465290404, "Cytomegalovirus infection ": 8.515328653531174, "Cytomegalovirus infection reactivation ": 9.17248510227432, "Cytomegalovirus test positive ": 9.3274580030513, "Cytomegalovirus viraemia ": 11.486706916890975, "Cytopenia ": 2.1262446092660165, "Defaecation urgency ": 5.980644113780618, "Dermatitis acneiform ": 3.676450076340119, "Diffuse large B-cell lymphoma ": 3.615964540311902, "Disease recurrence ": 4.998667833221429, "Disseminated intravascular coagulation ": 2.023234249621292, "Disseminated tuberculosis ": 8.433427005403283, "Drug hypersensitivity ": 4.083193918170512, "Drug ineffective ": 3.10091104297934, "Drug ineffective for unapproved indication ": 5.139986565293716, "Drug intolerance ": 6.483061164382083, "Drug specific antibody present ": 15.009365499079523, "Drug tolerance ": 5.221377074685469, "Drug-induced liver injury ": 2.1244589927835262, "Dust allergy ": 33.738508942202245, "Elbow deformity ": 102.90189639305636, "Enterococcal sepsis ": 28.706973867330056, "Enthesopathy ": 14.581936040276007, "Eosinophil count increased ": 6.863199150323931, "Eosinophilic granulomatosis with polyangiitis ": 23.017416920981383, "Epstein-Barr virus infection ": 15.582378315245045, "Erysipelas ": 4.114928242346909, "Exposure during pregnancy ": 2.677519140411743, "Faecal calprotectin increased ": 17.769401386261116, "Foetal anaemia ": 385.2330306315093, "Foetal exposure during pregnancy ": 3.7882817046004913, "Foetal growth restriction ": 13.827001883833129, "Forced expiratory volume decreased ": 19.321465843131357, "Frequent bowel movements ": 2.621922347805954, "Full blood count abnormal ": 4.928296576220172, "Fungal infection ": 2.144788536151914, "Fungal skin infection ": 11.052160059673248, "Gastroenteritis viral ": 3.2424489844519577, "Gastrointestinal disorder ": 3.5807988433284117, "Glucose tolerance impaired ": 3.7614694105568063, "Graft versus host disease ": 6.007800761251951, "Graft versus host disease in gastrointestinal tract ": 7.32398369749477, "Graft versus host disease in skin ": 7.593960279878285, "Granuloma skin ": 7.127619649037255, "Haemodialysis ": 6.794969885066548, "Haemolysis ": 5.227546476503685, "Haemophagocytic lymphohistiocytosis ": 5.350029710164987, "Haemoptysis ": 5.4080638296531145, "Haemorrhage foetal ": 606.3711542686203, "Haemorrhage in pregnancy ": 82.92966050686984, "Heart transplant rejection ": 29.68019956029113, "Hepatic enzyme abnormal ": 4.561878525028004, "Hepatic enzyme increased ": 2.412777288382531, "Hepatic fibrosis ": 7.556311397360255, "Hepatitis ": 2.6453429131154853, "Hepatitis cholestatic ": 2.3646911202377066, "Hepatosplenomegaly ": 8.039601851458428, "Hepatotoxicity ": 4.2104512197865045, "Herpes simplex ": 6.36213953867438, "Hypercalcaemia ": 2.5112646875090454, "Hypertriglyceridaemia ": 2.821445566590874, "Hypoxia ": 2.29469075456051, "Ileectomy ": 127.64466264750872, "Immunosuppressant drug level decreased ": 11.780541869409744, "Immunosuppression ": 5.250550230153238, "Infantile diarrhoea ": 86.67039268480089, "Inflammation ": 6.387299244013867, "Inflammatory bowel disease ": 19.92681508052921, "Inflammatory marker increased ": 4.682405345044963, "Infusion site thrombosis ": 247.64097312952595, "Interstitial lung disease ": 2.4908487113778346, "Intestinal operation ": 25.37263652666409, "Intraocular pressure increased ": 7.893003272315204, "Jaw fracture ": 11.631778293340776, "Joint stiffness ": 2.1005775604798003, "Joint swelling ": 2.194248321956379, "Kidney transplant rejection ": 19.57229845532473, "Labile hypertension ": 49.36745107373852, "Large intestine perforation ": 4.666936805319956, "Left ventricular hypertrophy ": 3.47999432521569, "Leukopenia ": 2.392263054654869, "Listeriosis ": 24.7935458554767, "Live birth ": 24.80128137119303, "Liver function test abnormal ": 5.157451865912398, "Liver function test increased ": 7.461416820425723, "Liver transplant rejection ": 15.425809834275736, "Low birth weight baby ": 5.583130756397774, "Lung disorder ": 3.1405136066194923, "Lung infiltration ": 3.564204587004535, "Lupus nephritis ": 22.1436252960797, "Lymphadenitis ": 4.337383149966338, "Lymphocyte count abnormal ": 49.83377020343119, "Lymphopenia ": 4.64123551442051, "Lymphoproliferative disorder ": 19.26038188178627, "Marrow hyperplasia ": 32.88875257240407, "Maternal exposure during breast feeding ": 2.9652835003547784, "Maternal exposure during pregnancy ": 5.601539424357867, "Maternal exposure timing unspecified ": 19.048869196746463, "Meningitis meningococcal ": 58.2547894768026, "Migraine with aura ": 2.5572870575290905, "Mite allergy ": 34.478415398783895, "Multiple-drug resistance ": 2.3092151046247458, "Musculoskeletal stiffness ": 2.319022258181382, "Mycotic allergy ": 40.50645639063959, "Myositis ": 4.061141250784096, "Nephropathy toxic ": 4.340298309892899, "Neuritis ": 14.448614041635516, "Neurological symptom ": 8.177357930385789, "Neutrophil count increased ": 10.7690417071381, "New onset refractory status epilepticus ": 1014.4020018036178, "Night sweats ": 5.886355105520511, "Nocardiosis ": 12.606180355223923, "Nodule ": 7.139703819151822, "Normal newborn ": 32.666677823068795, "Normochromic normocytic anaemia ": 21.42457439127578, "Obstruction ": 8.068280361910475, "Obstructive airways disorder ": 4.070173335759971, "Off label use ": 2.179807098671753, "Oral candidiasis ": 2.4290633647920425, "Overlap syndrome ": 60.38527609623851, "Pancreatitis ": 3.7280473082584846, "Pancytopenia ": 2.868270710557398, "Pleuritic pain ": 4.999005142093742, "Pneumocystis jirovecii pneumonia ": 4.925131245361223, "Pneumonia cytomegaloviral ": 14.63531653190448, "Polyomavirus-associated nephropathy ": 18.84997598958276, "Portal hypertension ": 4.706648151379506, "Post transplant lymphoproliferative disorder ": 18.139088290645475, "Pregnancy ": 6.860174707098705, "Premature baby ": 10.316462656130298, "Premature delivery ": 13.080970261225012, "Premature labour ": 20.26522192784463, "Proctitis ": 2.036643531196846, "Product availability issue ": 2.416652703066004, "Product use in unapproved indication ": 2.191676028804119, "Product use issue ": 2.049137160534142, "Productive cough ": 4.019316168300148, "Progressive multifocal leukoencephalopathy ": 3.8713836987885566, "Pulmonary alveolar haemorrhage ": 11.911018052991563, "Pulmonary fibrosis ": 4.399167356291366, "Pulmonary mass ": 3.3309915556307703, "Pulmonary vasculitis ": 62.82146623877089, "Quality of life decreased ": 2.807755171683055, "Red blood cell sedimentation rate abnormal ": 21.619128731854133, "Red blood cell sedimentation rate increased ": 3.5424117679233014, "Renal mass ": 34.59938186326724, "Renal transplant failure ": 31.615239081221564, "Respiratory symptom ": 16.93933053982527, "Retinal detachment ": 2.3893031371314213, "Retinal scar ": 109.29148635965105, "SLE arthritis ": 129.12502074221308, "Scleroderma ": 11.453699101396577, "Seborrhoeic dermatitis ": 15.710317257862553, "Sepsis ": 3.60898994872856, "Septic shock ": 2.544504392466658, "Shock ": 3.114413123063571, "Sjogren's syndrome ": 4.836823935372974, "Skin infection ": 8.176515840480876, "Skin laceration ": 2.694060611014957, "Skin lesion ": 2.675930361005156, "Skin mass ": 3.2421426728743783, "Sleep disorder due to a general medical condition ": 3.64214162071811, "Small intestinal resection ": 47.65729174312905, "Social problem ": 5.157767562418332, "Spinal compression fracture ": 2.90366414692523, "Spirometry abnormal ": 124.58187121052684, "Splenomegaly ": 4.46097998486924, "Squamous cell carcinoma ": 2.644768195570089, "Squamous cell carcinoma of skin ": 15.960631102842264, "Steroid dependence ": 26.86950048888321, "Synovitis ": 4.107474104897267, "Systemic lupus erythematosus ": 2.3637118211156816, "Tenosynovitis ": 11.59638775536134, "Therapeutic product effect decreased ": 10.12217932289879, "Therapeutic product effect incomplete ": 5.233617026481319, "Thiopurine methyltransferase decreased ": 611.4963049857162, "Thought blocking ": 114.0109227821457, "Thrombotic microangiopathy ": 8.000987943929552, "Tooth disorder ": 6.584551236495692, "Total lung capacity abnormal ": 348.9041624827356, "Transplant rejection ": 9.66023080029516, "Treatment failure ": 10.166078604398397, "Tuberculosis ": 2.5388070411503327, "Tubulointerstitial nephritis ": 2.1236268743872397, "Type 2 lepra reaction ": 128.57006553652965, "Ulcer ": 2.9505975248937943, "Upper respiratory tract infection ": 4.36603488519, "Urosepsis ": 3.162755231820702, "Uveitis ": 2.245735817656659, "Vasculitis ": 10.690232438254762, "Viral infection ": 2.283382891570792, "Vitiligo ": 3.60662459649064, "Weight decreased ": 2.8158026776346405} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/137.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/137.json new file mode 100644 index 00000000000..d26cb052624 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/137.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 4.430084591115952, "Abnormal dreams ": 7.453715920437804, "Agitation ": 2.919359540835329, "Altered state of consciousness ": 2.5745269417249164, "Aphasia ": 9.769345836094898, "Ataxia ": 7.537200585877913, "Atrial fibrillation ": 2.075501152781852, "Balance disorder ": 5.513015280333005, "Binocular eye movement disorder ": 344.266326098229, "Bradykinesia ": 41.09599081372991, "Brain stem stroke ": 232.4543451655005, "Cerebellar stroke ": 196.65092767014187, "Cerebral hypoperfusion ": 238.31788633870607, "Chronic inflammatory demyelinating polyradiculoneuropathy ": 155.5359141649399, "Cognitive disorder ": 7.275579916835688, "Compulsive shopping ": 134.35493495481504, "Confusional state ": 4.985940526503135, "Delirium ": 5.111232322887941, "Delusion ": 8.154149563324761, "Depressed level of consciousness ": 2.5234116562268456, "Device use error ": 64.0807080143582, "Diplopia ": 4.4984197913379145, "Disturbance in attention ": 5.900616285031044, "Drug interaction ": 4.640938593139303, "Dysarthria ": 5.983267079969332, "Dyskinesia ": 37.07866629272099, "Dysphonia ": 3.058425191190832, "Dysstasia ": 7.9863613490555805, "Euphoric mood ": 15.180975836807365, "Eye pain ": 5.332908202461363, "Fall ": 4.031295360698806, "Freezing phenomenon ": 251.44086568418496, "Gait disturbance ": 5.82534501337816, "Gambling disorder ": 148.12390542308947, "General physical health deterioration ": 2.557411651368657, "Hallucination ": 14.574263652342466, "Hallucination, visual ": 25.5602279768312, "Hypersexuality ": 213.63336841416935, "Hyporesponsive to stimuli ": 82.41361293303027, "Impulse-control disorder ": 64.74050840141537, "Micturition urgency ": 21.221128594536346, "Mobility decreased ": 2.9072966027211464, "Movement disorder ": 3.906124373508813, "Myocardial ischaemia ": 14.943365240846106, "Nasal mucosal disorder ": 170.40505820682887, "Neuralgia ": 7.314318115155658, "Nocturia ": 29.023614939660504, "Obsessive-compulsive disorder ": 46.797422012772095, "Oedema peripheral ": 3.240014114926104, "Oliguria ": 13.40145811821922, "On and off phenomenon ": 344.7596214391791, "Orthostatic hypotension ": 15.49084771624942, "Parkinson's disease ": 33.47523438910083, "Parkinsonism ": 21.3905529021994, "Photopsia ": 37.23206085361342, "Post micturition dribble ": 1595.9617023553117, "Rectal haemorrhage ": 2.3938827784808345, "Restlessness ": 6.917620583942053, "Serotonin syndrome ": 11.671185138329973, "Sudden onset of sleep ": 61.26216181591614, "Suicide attempt ": 2.629735575778812, "Tremor ": 2.6205309650510564} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/138.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/138.json new file mode 100644 index 00000000000..cedfb83e890 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/138.json @@ -0,0 +1 @@ +{"Asthma ": 9.995585176547452, "Cataract ": 7.815669624254697, "Conjunctival hyperaemia ": 43.730374107185526, "Corneal oedema ": 96.09666368828076, "Dyspnoea ": 2.551894340827068, "Epidermal necrosis ": 844.2336356273643, "Eye irritation ": 11.497342259300076, "Eye pain ": 8.844785519530927, "Full blood count abnormal ": 37.54490072368649, "Glaucoma ": 22.032096395214975, "Haemoglobin decreased ": 25.915378552600057, "Intraocular pressure increased ": 58.93334586442949, "Loss of personal independence in daily activities ": 16.78487835844961, "Nikolsky's sign ": 1314.909636104503, "Off label use ": 5.530340655516756, "Rash erythematous ": 23.076098587609238, "Rash papular ": 69.24216472645077, "Sleep disorder due to a general medical condition ": 61.5249815100347, "Therapeutic product effect incomplete ": 17.83718082994475, "Toxic epidermal necrolysis ": 146.66405515416187, "Vision blurred ": 4.478210695257494, "Visual acuity reduced ": 16.361061148031908, "Visual impairment ": 5.181402587196589, "Wheezing ": 3.089160737706595} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/139.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/139.json new file mode 100644 index 00000000000..554a3b89645 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/139.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.064464228115815, "Coma ": 3.954640347295145, "Cystic fibrosis ": 291.21197508291993, "Drug hypersensitivity ": 3.365402598431708, "Drug reaction with eosinophilia and systemic symptoms ": 8.919600813126442, "Drug resistance ": 14.390025647687796, "Eosinophilia ": 19.18348230403525, "Haemoptysis ": 6.239221114461407, "Hepatic enzyme increased ": 3.312947252087437, "Hepatic function abnormal ": 2.050770917060521, "Infection ": 3.182001480149856, "Infective pulmonary exacerbation of cystic fibrosis ": 112.58805987505896, "Multiple organ dysfunction syndrome ": 6.5848186566809535, "Off label use ": 2.2777791200898347, "Pathogen resistance ": 55.97792805790844, "Pneumonia ": 2.3354444439338824, "Pseudomonas infection ": 65.86105513431144, "Rash maculo-papular ": 3.864900755734383, "Renal impairment ": 2.0553352644625478, "Respiratory tract infection ": 18.13877969437827, "Septic shock ": 10.637145308357953, "Shock ": 11.323559073794, "Skin exfoliation ": 8.08104651117738, "Staphylococcal infection ": 11.905407732441558, "Tracheo-oesophageal fistula ": 751.2570500801398} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/14.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/14.json new file mode 100644 index 00000000000..6d35b0cf191 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/14.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 8.553063250381046, "Alopecia ": 7.8681949820267825, "Anti-cyclic citrullinated peptide antibody positive ": 43.30790007239304, "Arthropathy ": 17.368259943870395, "Blister ": 15.569127133051085, "Confusional state ": 6.406938621179766, "Contraindicated product administered ": 18.46441229360237, "Contusion ": 13.452909459905571, "Discomfort ": 17.43727164043431, "Duodenal ulcer perforation ": 67.64089812316634, "Folliculitis ": 56.30894294731588, "Gastrointestinal disorder ": 14.64563067031852, "Glossodynia ": 26.077630807602503, "Hand deformity ": 36.31596680891196, "Helicobacter infection ": 67.5917558636739, "Hepatic enzyme increased ": 14.27090988199706, "Hypersensitivity ": 5.834682110638103, "Ill-defined disorder ": 32.997923253061934, "Impaired healing ": 43.76835572255833, "Infection ": 12.566858614856026, "Infusion related reaction ": 21.988815956056705, "Irritable bowel syndrome ": 51.21877906216128, "Joint swelling ": 11.752481310346198, "Lower respiratory tract infection ": 31.46455341163997, "Muscle injury ": 101.14402644684608, "Nasopharyngitis ": 11.813667041060732} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/140.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/140.json new file mode 100644 index 00000000000..ef40b5c0497 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/140.json @@ -0,0 +1 @@ +{"Blood glucose decreased ": 49.68690995851325, "Blood glucose increased ": 7.972321510755766, "Drug ineffective ": 4.14748100383315, "Eye pain ": 11.729345344384743, "Hypoglycaemia ": 45.51686243448775, "Hypoglycaemic unconsciousness ": 180.40315723235517, "Loss of consciousness ": 5.664399825894125, "Nasal discomfort ": 260.4657714333368, "Product dose omission issue ": 5.789049928819617, "Rhinalgia ": 681.5825439883189} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/141.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/141.json new file mode 100644 index 00000000000..1e73f6e20db --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/141.json @@ -0,0 +1 @@ +{"Abortion induced ": 27.71601358098749, "Abortion spontaneous ": 5.522991508505197, "Acute hepatic failure ": 8.85580735725713, "Adverse event ": 3.444889351983542, "Alanine aminotransferase increased ": 11.98057454619779, "Ascites ": 6.507745034903077, "Aspartate aminotransferase increased ": 3.077827369054901, "Blood alkaline phosphatase increased ": 6.223079080843263, "Blood bilirubin increased ": 4.681813342421798, "Blood creatine phosphokinase increased ": 6.307651211340066, "Blood creatinine increased ": 3.239209824122114, "Blood lactate dehydrogenase increased ": 2.491706391072863, "Blood lactic acid increased ": 9.249199967021614, "Blood urea increased ": 6.882917689052484, "Cardiac failure acute ": 13.218519776758953, "Death ": 4.024978053400881, "Drug eruption ": 2.3097560264678463, "Drug ineffective ": 3.226699886492401, "Drug resistance ": 56.71241890902205, "Drug tolerance ": 54.379619228667366, "Exposure via body fluid ": 202.87908817627135, "Gamma-glutamyltransferase increased ": 4.92038040648754, "Generalised oedema ": 4.167501468500933, "Hepatic cancer ": 46.23848180227015, "Hepatic cirrhosis ": 21.07978926239514, "Hepatic encephalopathy ": 14.602783825908674, "Hepatic failure ": 8.603040182070085, "Hepatic function abnormal ": 2.002145938159553, "Hepatitis B ": 68.1807118252519, "Hepatitis B DNA increased ": 1452.9984802120198, "Hepatitis B reactivation ": 56.961362588635126, "Hepatocellular carcinoma ": 27.412576373237403, "Hospitalisation ": 3.7727952993017633, "Jaundice ": 4.588502279679656, "Lactic acidosis ": 9.605478540840526, "Lipase increased ": 6.024164602347864, "Liver disorder ": 8.605807127052278, "Liver injury ": 3.5877528418912026, "Liver transplant ": 43.0860132100201, "Lymphoma ": 5.541480638555672, "Maternal exposure during pregnancy ": 3.500331343764132, "Neoplasm malignant ": 2.8650002289867538, "No adverse event ": 3.566535628533104, "Pancytopenia ": 2.9125412406315285, "Paternal exposure timing unspecified ": 131.9844283127463, "Pregnancy ": 17.417996214854522, "Product quality issue ": 2.1234511509134344, "Renal failure ": 2.0194880397442945, "Renal impairment ": 3.99065945160717, "Surgery ": 4.843632526410175, "Suspected counterfeit product ": 89.52784781182268, "Therapeutic response decreased ": 9.067227968088512, "Thrombotic microangiopathy ": 17.811544225557494, "Transaminases increased ": 5.250339805973239, "Treatment noncompliance ": 5.368834014042079, "Viral load increased ": 166.47896318073563, "Virologic failure ": 56.15312567319019} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/142.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/142.json new file mode 100644 index 00000000000..3e739a485c3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/142.json @@ -0,0 +1 @@ +{"Cardio-respiratory arrest ": 26.3975180191986, "Completed suicide ": 44.89813050372836, "Overdose ": 8.749745194088035, "Toxicity to various agents ": 38.30106442042462} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/143.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/143.json new file mode 100644 index 00000000000..df4e2ee9487 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/143.json @@ -0,0 +1 @@ +{"Arrhythmia ": 11.460978047712834, "Arthritis ": 65.7265361981178, "Blood folate decreased ": 5597.03623549758, "Cardiac arrest ": 16.209540481332596, "Drug ineffective ": 6.357140274324183, "Off label use ": 2.881082651748428, "Platelet count decreased ": 29.991794752000008, "Pneumonia ": 14.640098005305184, "Product use in unapproved indication ": 4.790899862496336} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/144.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/144.json new file mode 100644 index 00000000000..5927b1547eb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/144.json @@ -0,0 +1 @@ +{"Acute graft versus host disease in intestine ": 46.38427783947407, "Adenovirus infection ": 40.59654277619472, "Anuria ": 8.82062798509484, "Ascites ": 2.88510586472433, "Aspergillus infection ": 24.4099178951502, "BK virus infection ": 113.15181663826073, "Blood alkaline phosphatase increased ": 2.0495281416641, "Blood creatinine increased ": 5.074184380603878, "Bone marrow failure ": 10.24004835820816, "Bronchopulmonary aspergillosis ": 21.782374444423755, "Candida sepsis ": 83.3389577531939, "Chronic allograft nephropathy ": 304.555245457088, "Complications of transplanted kidney ": 385.94920878239367, "Cystitis haemorrhagic ": 21.471801644819102, "Cytomegalovirus colitis ": 80.2799663194893, "Cytomegalovirus enterocolitis ": 75.69565398023317, "Cytomegalovirus infection ": 104.89790707437676, "Cytomegalovirus infection reactivation ": 47.65441980889223, "Cytomegalovirus test positive ": 38.7675211700053, "Cytomegalovirus viraemia ": 110.03705505900382, "Cytopenia ": 6.106655348430063, "Disease recurrence ": 9.549150639687678, "Drug ineffective for unapproved indication ": 3.389537903435666, "Drug resistance ": 14.521440558411316, "Enterococcal infection ": 56.48677532816336, "Epstein-Barr virus infection ": 35.947028146079234, "Escherichia infection ": 23.617272533172518, "Glomerulosclerosis ": 151.73728268961497, "Graft versus host disease ": 19.152850863362566, "Graft versus host disease in gastrointestinal tract ": 82.80753994802072, "Graft versus host disease in skin ": 61.14477896990847, "Haematuria ": 4.774283069027482, "Human herpesvirus 6 infection ": 52.50389610471233, "Immunosuppressant drug level increased ": 27.704005804894063, "Kaposi's sarcoma ": 31.38938057871821, "Kidney fibrosis ": 60.67202096809904, "Kidney transplant rejection ": 237.7298029655598, "Klebsiella infection ": 28.51725129953702, "Leukopenia ": 5.887401224624318, "Liver transplant rejection ": 49.61194538204336, "Lung infiltration ": 7.891247692447439, "Lymphopenia ": 6.699503461802639, "Mucormycosis ": 37.53034447575481, "Multiple organ dysfunction syndrome ": 10.207100041941702, "Nephropathy ": 3.632196255333132, "Nephropathy toxic ": 25.10255011739549, "Neutropenia ": 2.427631852611056, "Nocardiosis ": 69.17041958208573, "Off label use ": 2.461509191075461, "Pancytopenia ": 5.230846874129729, "Pathogen resistance ": 16.922712759103167, "Pleural effusion ": 5.060201675862896, "Pneumocystis jirovecii pneumonia ": 29.856816599360705, "Pneumonia bacterial ": 10.052655217649246, "Polyomavirus-associated nephropathy ": 373.9499872182839, "Post transplant lymphoproliferative disorder ": 55.8031209991636, "Posterior reversible encephalopathy syndrome ": 11.779810246461874, "Product use in unapproved indication ": 4.91507111556063, "Proteinuria ": 5.278645075495335, "Pseudomonas infection ": 23.609301228922348, "Renal impairment ": 5.443871015433787, "Renal tubular disorder ": 15.117970114902938, "Renal tubular necrosis ": 27.10429770032339, "Respiratory failure ": 5.231258839369625, "Sepsis ": 2.937060749564783, "Septic shock ": 4.759676563143698, "Shock haemorrhagic ": 6.822520705231788, "Skin lesion ": 4.000702097071331, "Staphylococcal infection ": 4.604278733726862, "Systemic mycosis ": 73.45076368504093, "Therapeutic response decreased ": 3.120586472987656, "Thrombotic microangiopathy ": 30.361179545275668, "Transplant dysfunction ": 62.44376262482477, "Transplant failure ": 60.80451264147367, "Transplant rejection ": 159.5983932521416, "Tubulointerstitial nephritis ": 18.187241978353956, "Urinary tract infection ": 3.103544779536041, "Urine output decreased ": 11.94043871972373} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/145.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/145.json new file mode 100644 index 00000000000..e80751aa889 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/145.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 29.40566573794465, "Alanine aminotransferase increased ": 2.9893862390982284, "Aphonia ": 11.55315777248286, "Aspartate aminotransferase increased ": 3.1973963114176462, "Blood creatinine increased ": 2.1602848864651096, "Blood lactate dehydrogenase increased ": 4.978233153990103, "Blood pressure increased ": 2.639365297454336, "Blood pressure systolic increased ": 7.94399100849343, "Blood thyroid stimulating hormone increased ": 18.57556911900037, "C-reactive protein increased ": 3.689249932575298, "Colitis ": 3.448389427707756, "Disease progression ": 14.28773988521418, "Dysphonia ": 11.912090996202645, "Hepatic function abnormal ": 5.424957449979547, "Hepatitis ": 4.956567357485743, "Hypertension ": 7.225008610698339, "Hyperthyroidism ": 14.328706484678364, "Hypothyroidism ": 41.53422504399764, "Infusion related reaction ": 30.263936496241936, "Liver disorder ": 4.64996926001087, "Myocarditis ": 7.7464849406626, "Myositis ": 27.05833074633933, "Neoplasm progression ": 23.7186344047527, "Oxygen saturation decreased ": 6.948926063799539, "Palmar-plantar erythrodysaesthesia syndrome ": 24.120606528277506, "Proteinuria ": 9.551171466749564, "Stomatitis ": 5.269570493226762, "Thyroiditis ": 37.2716292013344} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/146.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/146.json new file mode 100644 index 00000000000..f9caac247e0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/146.json @@ -0,0 +1 @@ +{"Cerebrovascular accident ": 8.078429702206204, "Hypoaesthesia ": 6.687718745860841} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/147.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/147.json new file mode 100644 index 00000000000..01a1a0cb057 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/147.json @@ -0,0 +1 @@ +{"Febrile neutropenia ": 29.681723734005992} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/148.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/148.json new file mode 100644 index 00000000000..3521a810d3f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/148.json @@ -0,0 +1 @@ +{"Acute respiratory failure ": 7.586738868796107, "Affect lability ": 2.762911713375732, "Alanine aminotransferase increased ": 11.289581391857604, "Alcohol abuse ": 9.479007261780232, "Alcohol poisoning ": 16.803271022461573, "Amylase increased ": 3.8008549373551954, "Anaemia ": 5.101418975562086, "Ascites ": 2.4510172527365754, "Aspartate aminotransferase increased ": 13.235145261287148, "Bacterial infection ": 2.000699151960752, "Bilirubin conjugated increased ": 15.179544476593026, "Blood albumin decreased ": 20.64720499396428, "Blood bilirubin increased ": 2.5543675093740186, "Blood calcium decreased ": 15.0832713668674, "Blood chloride decreased ": 41.89213916216588, "Blood chloride increased ": 16.422352830707872, "Blood creatinine decreased ": 43.18891062902315, "Blood creatinine increased ": 2.749508125605104, "Blood magnesium decreased ": 45.58691371230553, "Blood 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4.991611056082786, "Pyelonephritis chronic ": 101.42117345549948, "Red blood cell count increased ": 15.872177732558368, "Respiratory distress ": 4.531881974107412, "Respiratory failure ": 11.830108981004244, "Right ventricular dysfunction ": 28.69246175133772, "Right ventricular failure ": 7.348301898010085, "Shock haemorrhagic ": 2.864585034751503, "Sinus bradycardia ": 2.07513595212826, "Skin discolouration ": 2.4924144560078094, "Sputum culture positive ": 93.69305410831306, "Stenotrophomonas infection ": 29.902730725323096, "Sudden death ": 3.55551732828071, "Tachypnoea ": 2.693991802552421, "Toxic optic neuropathy ": 201.1815642919925, "Transaminases increased ": 3.1775667694290477, "Treatment failure ": 3.448128834514656, "Treatment noncompliance ": 10.921704923575964, "Tricuspid valve incompetence ": 19.80169817548116, "Tuberculosis ": 79.38512672191074, "Underdose ": 10.686852435306, "Urine output decreased ": 6.362609138555015, "Vascular encephalopathy ": 117.62320384450376, "Ventricular extrasystoles ": 7.571458519861368, "Vomiting ": 2.6780495181921333, "White blood cell count increased ": 14.275342261473712, "White blood cells urine positive ": 23.73431312126392} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/149.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/149.json new file mode 100644 index 00000000000..a3b72a053de --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/149.json @@ -0,0 +1 @@ +{"Adverse event ": 29.4899366289344, "Cough ": 5.57457586435228, "Death ": 4.117188296088964, "Disease progression ": 21.492601542753423, "Inguinal hernia ": 398.911522618452, "Keratopathy ": 6664.325700344432, "Ocular toxicity ": 2921.8518615322105, "Off label use ": 6.583446680724551, "Plasma cell myeloma ": 81.30944715832501, "Platelet count decreased ": 9.395397853734124, "Thrombocytopenia ": 6.633606057169947, "Visual acuity reduced ": 74.72834515800422, "Visual impairment ": 14.39819922915318} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/15.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/15.json new file mode 100644 index 00000000000..daa6cb3ea89 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/15.json @@ -0,0 +1 @@ +{"Depression ": 4.811151319976349, "Drug dependence ": 197.37695047392972, "Emotional distress ": 11.540852615818826, "Overdose ": 11.59275491568321, "Suicidal ideation ": 8.057830598170321} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/150.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/150.json new file mode 100644 index 00000000000..56a4033900b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/150.json @@ -0,0 +1 @@ +{"Off label use ": 4.082829155590815, "Urinary tract infection ": 16.386387938060963} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/151.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/151.json new file mode 100644 index 00000000000..ca64b99b38c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/151.json @@ -0,0 +1 @@ +{"Acne ": 4.987092114352351, "Arthritis ": 11.67689489268312, "Arthropathy ": 5.827965804454518, "Blood cholesterol ": 502.00280067980657, "Blood cholesterol abnormal ": 60.07266253242842, "Blood pressure decreased ": 8.327027918230938, "Blood pressure increased ": 3.942898051325023, "Bronchitis ": 4.36990534305016, "Calcinosis ": 251.7007607167891, "Cystitis ": 5.0608465792277615, "Diabetes mellitus ": 2.205510694192626, "Diverticulitis ": 4.885846385773479, "Gait disturbance ": 2.3867051105033426, "Gastrointestinal disorder ": 2.65490482008081, "Hand deformity ": 14.616996410922086, "Hypersomnia ": 26.559866388981927, "Immune system disorder ": 8.776419611016381, "Inflammation ": 7.592577911403811, "Joint dislocation ": 69.43455530613893, "Kidney infection ": 49.62409140117257, "Loss of personal independence in daily activities ": 9.13361982811423, "Lower respiratory tract infection ": 5.316073800425885, "Migraine with aura ": 18.825022305191485, "Multiple allergies ": 91.81517002415158, "Nasopharyngitis ": 5.546520932349633, "Nephrolithiasis ": 21.24616349238205, "Personality change due to a general medical condition ": 3441.48211353264, "Photophobia ": 3.680925238878539, "Poor quality sleep ": 17.64763999737211, "Product dose omission issue ": 6.605336591084175, "Renal disorder ": 16.598411222300783, "SLE arthritis ": 2302.5150139179664, "Sinusitis ": 3.493238138392944, "Skin induration ": 120.83288024406104, "Skin lesion ": 4.764061773365795, "Social problem ": 85.62767969823344, "Spinal disorder ": 58.04743129635512, "Systemic lupus erythematosus ": 12.792718898788204, "Urinary tract infection ": 2.1392731127664946, "Urine abnormality ": 185.6437364662365, "Varicose vein ": 90.30049662250867, "Vein disorder ": 142.91539099639402, "Walking aid user ": 127.29738705648506} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/152.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/152.json new file mode 100644 index 00000000000..b32221ebde1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/152.json @@ -0,0 +1 @@ +{"Abdominal pain lower ": 79.10508326271024, "Ascites ": 161.00914269102768, "Dyspnoea ": 2.2847065573708543, "Ovarian hyperstimulation syndrome ": 1748.431010687586} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/153.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/153.json new file mode 100644 index 00000000000..4805f06e743 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/153.json @@ -0,0 +1 @@ +{"Myalgia ": 13.98203209107439} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/154.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/154.json new file mode 100644 index 00000000000..4f895fe399a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/154.json @@ -0,0 +1 @@ +{"Accidental exposure to product ": 3.4356332218278096, "Adverse drug reaction ": 3.0537326151522164, "Antiphospholipid syndrome ": 6.886619903555781, "Arthritis ": 2.818988549588164, "Bacterial infection ": 2.736413516238663, "Bedridden ": 2.5178329136492925, "Blood cholesterol abnormal ": 3.3069041875687133, "Blood test abnormal ": 2.617379042781179, "Brain fog ": 2.1332784180768622, "Bronchitis ": 3.955046991806376, "Butterfly rash ": 28.126996441217948, "Calcinosis ": 7.49986041760068, "Cardiac operation ": 2.7978749982041404, "Cataract operation ": 3.2524693257018487, "Catarrh ": 4.284805757933276, "Cellulitis ": 2.804685630571506, "Central nervous system lupus ": 133.52816334255775, "Cerebrospinal fluid leakage ": 8.395179214702706, "Cholecystectomy ": 2.596454991117624, "Chronic cutaneous lupus erythematosus ": 25.003281218748143, "Circumstance or information capable of leading to medication error ": 42.14962042536585, "Condition aggravated ": 2.407857266631723, "Coronavirus infection ": 8.80104592298463, "Coronavirus test positive ": 25.31449839667781, "Cutaneous lupus erythematosus ": 18.58318381084857, "Cystitis ": 2.3083500739572926, "Decreased immune responsiveness ": 8.93098225373147, "Dengue fever ": 28.03295257333437, "Depression ": 2.1400587771739827, "Disability ": 2.911525200322367, "Discouragement ": 20.354368244169887, "Disease recurrence ": 2.3263480171405644, "Diverticulitis ": 2.693095472601253, "Drug effect less 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3.122456101302248, "Inflammation ": 3.025540944226234, "Influenza ": 2.990435487683974, "Injection site bruising ": 4.221267432906119, "Injection site haemorrhage ": 5.388953773604058, "Intervertebral disc protrusion ": 2.167926738944617, "JC virus infection ": 10.913633692233969, "Joint dislocation ": 3.1363259744576464, "Kidney infection ": 10.250514397730178, "Knee arthroplasty ": 3.369721812508712, "Knee operation ": 2.768289005750882, "Laboratory test abnormal ": 4.011493791593085, "Laryngeal oedema ": 2.2067016550619942, "Laryngitis ": 3.319218013145508, "Limb injury ": 4.100039900216026, "Limb operation ": 9.882498156932748, "Live birth ": 3.507425948673032, "Localised infection ": 4.7028537016138685, "Lung disorder ": 2.7979213404805585, "Lupus nephritis ": 167.11274984090224, "Lymphoma ": 2.2037318005382605, "Lymphopenia ": 2.593712939407104, "Meningitis ": 2.146702973141024, "Mental impairment ": 2.480285546723076, "Multiple allergies ": 4.533598841618911, "Nasal ulcer ": 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2.423575731257198} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/156.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/156.json new file mode 100644 index 00000000000..a54e0e51c06 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/156.json @@ -0,0 +1 @@ +{"Accidental exposure to product ": 5.040554654149069, "Accidental overdose ": 5.519445121223284, "Agitation ": 2.5765772321480163, "Alcohol abuse ": 22.97173161425185, "Altered state of consciousness ": 3.078522396003399, "Apnoea ": 6.828105434603596, "Blood creatine phosphokinase increased ": 2.9166141255154985, "Bradypnoea ": 24.296804307395703, "Brain oedema ": 11.160649193841117, "Cardiac arrest ": 7.560098872954715, "Cardio-respiratory arrest ": 72.47240226216957, "Coma ": 10.88343757801302, "Completed suicide ": 61.5128329444677, "Death ": 5.4352271378574, "Depressed level of consciousness ": 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36.4015154773553, "Toxicity to various agents ": 6.998741173808761, "Ventricular arrhythmia ": 105.43338101016818} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/158.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/158.json new file mode 100644 index 00000000000..178a510d79b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/158.json @@ -0,0 +1 @@ +{"Anterior chamber cell ": 1357.3753331681553, "Anterior chamber flare ": 1576.6926865036194, "Anterior chamber inflammation ": 451.4766247129453, "Arteritis ": 93.67428826407624, "Blindness ": 35.17948017097839, "Blindness transient ": 44.23872226447951, "Blindness unilateral ": 24.55406213144068, "Cataract ": 4.149969651199775, "Chorioretinitis ": 471.1826648627459, "Choroidal neovascularisation ": 360.2528882273764, "Conjunctival hyperaemia ": 12.886013369570108, "Corneal disorder ": 29.88471962685086, "Corneal 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/16.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/16.json new file mode 100644 index 00000000000..c6d48c01f7e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/16.json @@ -0,0 +1 @@ +{"Drug ineffective ": 23.07043989973285, "Macular degeneration ": 2094.342912544314} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/160.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/160.json new file mode 100644 index 00000000000..a9eced0f8f9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/160.json @@ -0,0 +1 @@ +{"Influenza like illness ": 4.603300738466763, "Off label use ": 4.56679690509033, "Pruritus ": 5.596282910433106} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/161.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/161.json new file mode 100644 index 00000000000..0ae51cf9dcc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/161.json @@ -0,0 +1 @@ +{"Bradycardia ": 9.180797974562536, "Completed suicide ": 108.4257044897281, "Drug interaction ": 2.6753680037548326, "Intentional overdose ": 8.088083989614736, "Suicide attempt ": 6.692608583967592, "Syncope ": 2.87167496675773, "Toxicity to various agents ": 26.78575417321673} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/162.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/162.json new file mode 100644 index 00000000000..275bab19906 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/162.json @@ -0,0 +1 @@ +{"Completed suicide ": 69.70506869533357} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/163.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/163.json new file mode 100644 index 00000000000..cce16993556 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/163.json @@ -0,0 +1 @@ +{"Intentional overdose ": 80.7833639710511, "Suicide attempt ": 78.03396815773459, "Tachycardia ": 18.1461546350233} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/164.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/164.json new file mode 100644 index 00000000000..075f944ab38 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/164.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 2.312950445121351, "Abscess ": 10.47828900988403, "Adverse event ": 2.0845571676533283, "Alanine aminotransferase increased ": 4.315551531010428, "Application site erythema ": 5.275672012420706, "Aspartate aminotransferase increased ": 4.192710698141751, "Ataxia ": 3.682963182425097, "Autoimmune hepatitis ": 11.16210432686378, "Autoimmune thyroiditis ": 6.594795665515045, "Breast cancer ": 2.9509869245289586, "Cardiomyopathy ": 4.149613964252412, "Cellulitis ": 4.31690922074272, "Depressed mood ": 2.510332754822995, "Depression ": 3.182238101549189, "Device operational issue ": 29.42985552102633, "Dilated cardiomyopathy ": 6.03127253524514, "Drug delivery system malfunction ": 9.141797321708395, "Erysipelas ": 5.753397019313024, "Expanded disability status scale score increased ": 263.1656190182535, "Gait disturbance ": 3.1365146214785318, "Gait inability ": 2.088595588605608, "Gamma-glutamyltransferase increased ": 8.029269148548016, "Hemiparesis ": 3.0333922882343907, "Hemiplegia ": 2.756704943379932, "Hepatic enzyme increased ": 2.4083389078484605, "Hepatic steatosis ": 3.333658828091606, "Hepatitis ": 3.45065821253789, "Hyperthyroidism ": 2.6736518743485163, "Incorrect dose administered by device ": 15.98675005858739, "Influenza like illness ": 5.200479261848722, "Injection site abscess ": 192.44242192436116, "Injection site atrophy ": 94.60407854944586, "Injection site bruising ": 8.995978415991233, "Injection site cellulitis ": 88.50121750688037, "Injection site discolouration ": 49.09361632465938, "Injection site erythema ": 6.455033157458272, "Injection site haematoma ": 3.429145212862429, "Injection site haemorrhage ": 7.617306709067428, "Injection site induration ": 19.87274297123187, "Injection site infection ": 69.9395905386055, "Injection site inflammation ": 3.108856076207028, "Injection site mass ": 14.03604619650286, "Injection site necrosis ": 242.46496516396616, "Injection site nodule ": 16.28219088088887, "Injection site oedema ": 5.978895877557384, "Injection site pain ": 3.4249191496727875, "Injection site rash ": 8.279254956593867, 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"Cystitis ": 9.102223441629466, "Dizziness ": 2.0706440640635884, "Drug ineffective for unapproved indication ": 4.61108210231941, "Drug interaction ": 4.181480808333663, "Dry eye ": 6.721857575798488, "Dry mouth ": 11.685931224457336, "Dry throat ": 5.28052200494966, "Dyspepsia ": 2.592440165742671, "Dysuria ": 14.081119804603617, "Erectile dysfunction ": 3.740623297324343, "Eye swelling ": 3.440645511527012, "Eyelid oedema ": 7.685191081438687, "Flatulence ": 2.274305979639096, "Gastritis ": 2.879069385533123, "Glaucoma ": 3.0240552842945814, "Heart rate increased ": 2.699753889760992, "Heart rate irregular ": 3.0533519580028323, "Hypertension ": 6.695449284075036, "Hypertensive crisis ": 14.94899623366564, "Hypertonic bladder ": 25.58645950238521, "Inappropriate schedule of product administration ": 2.651116169060718, "Incontinence ": 4.789270373588477, "Intentional product misuse ": 2.4986282477666037, "Joint swelling ": 2.239649734535078, "Micturition urgency ": 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/166.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/166.json new file mode 100644 index 00000000000..8e133007cbf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/166.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 6.029422655673468, "Abscess ": 2.243181028513752, "Acquired gene mutation ": 12.322723808550412, "Acute abdomen ": 9.442356420260865, "Acute myeloid leukaemia ": 3.299038200365937, "Adenocarcinoma ": 9.86493757326402, "Adenocarcinoma of colon ": 30.191752592329667, "Anaemia ": 2.544306238932652, "Anastomotic leak ": 79.46785122459488, "Ascites ": 4.268068885608932, "Astrocytoma, low grade ": 81.06149364194692, "Autoimmune haemolytic anaemia ": 2.5829495728601635, "Bacteraemia ": 5.805863403967593, "Blindness ": 2.899225985783082, "Blood albumin decreased ": 4.0883085805486585, "Blood pressure diastolic increased ": 19.40030522254752, "Body 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2.275603479062707, "Hepatitis B reactivation ": 12.350542085568891, "Hiccups ": 7.797453592364011, "Hydronephrosis ": 2.4075860870194914, "Hyperammonaemia ": 2.092531567619367, "Hyperammonaemic encephalopathy ": 7.967767992182752, "Hyperbilirubinaemia ": 3.19566443575081, "Hypertension ": 4.434333862466667, "Hypoalbuminaemia ": 3.7346876644465583, "Hypomagnesaemia ": 6.844847831025537, "Hypophosphataemia ": 2.0769990626770545, "Ileus ": 6.410873255619391, "Immune-mediated hepatitis ": 4.86306683018024, "Incoherent ": 10.905387006102924, "Interstitial lung disease ": 2.3784154819380974, "Intestinal obstruction ": 3.333086100123297, "Intestinal perforation ": 11.948464949107269, "Invasive ductal breast carcinoma ": 5.514887515241198, "Large intestinal obstruction ": 15.071988428443808, "Large intestine perforation ": 22.42168051045469, "Left ventricular dysfunction ": 6.381683760872453, "Leukoencephalopathy ": 3.8912272912641073, "Leukopenia ": 4.698945038600277, "Lower gastrointestinal 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"Paronychia ": 16.433894527846267, "Performance status decreased ": 2.892702846091133, "Peripheral sensory neuropathy ": 9.75463611979253, "Peritonitis ": 3.871864109144701, "Pigmentation disorder ": 3.023676281123968, "Platelet count decreased ": 3.52797003831426, "Pleural effusion ": 2.018593796112311, "Pneumocystis jirovecii pneumonia ": 3.234417694715552, "Pneumonitis ": 3.0566644517396244, "Polyneuropathy ": 3.3054588069212545, "Portal hypertension ": 16.905831135172203, "Portal vein thrombosis ": 8.682007320946147, "Posterior reversible encephalopathy syndrome ": 16.037488480954025, "Protein urine present ": 6.153686575012781, "Proteinuria ": 15.406635104997276, "Pseudocirrhosis ": 128.3624554030931, "Pulmonary artery thrombosis ": 26.998085716158297, "Pulmonary embolism ": 2.522776190224362, "Pulmonary toxicity ": 4.831504052308411, "Rectal adenocarcinoma ": 47.93257665093618, "Rectal cancer ": 6.517178790351814, "Rectal haemorrhage ": 2.9698872103896083, "Red blood cell count decreased ": 2.50550337315122, "Scleral thinning ": 224.95115979740183, "Second primary malignancy ": 2.515316780227105, "Septic shock ": 2.5083269637545187, "Skin hyperpigmentation ": 2.801901253308261, "Skin toxicity ": 17.51386657213315, "Small intestinal obstruction ": 5.27996869781104, "Small intestinal perforation ": 11.586536902182903, "Splenomegaly ": 3.538136184408017, "Stoma site haemorrhage ": 37.741938975966605, "Stomatitis ": 3.557000017307568, "Subretinal fluid ": 16.728730146852527, "Systemic candida ": 7.633130533655028, "Temperature intolerance ": 2.58504977342049, "Therapy non-responder ": 3.0047148341076952, "Therapy partial responder ": 15.221348171998528, "Thrombocytopenia ": 4.762123677625729, "Thrombocytopenic purpura ": 4.079120258028757, "Thrombotic microangiopathy ": 4.171632426132098, "Treatment failure ": 2.132631690154196, "Tumour lysis syndrome ": 3.112194799622257, "Tumour marker increased ": 5.829688411666147, "Tumour necrosis ": 59.87721328503066, "Vascular device infection ": 3.7105654893141375, "Venoocclusive liver disease ": 3.338730302163613, "White blood cell count abnormal ": 3.17015856026532, "White blood cell count decreased ": 6.617793594097158, "Wound dehiscence ": 35.20135165165497, "Wound infection ": 4.881148648130219} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/167.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/167.json new file mode 100644 index 00000000000..d8df6cbc4cb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/167.json @@ -0,0 +1 @@ +{"Bronchitis ": 14.135005294474642, "Chronic obstructive pulmonary disease ": 34.20696330066647, "Dyspnoea ": 3.972088226332475, "Intentional product misuse ": 14.79702221649479, "Pneumonia ": 3.3505466030642728, "Product dose omission issue ": 5.51857019316779} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/168.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/168.json new file mode 100644 index 00000000000..28ab7b71676 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/168.json @@ -0,0 +1 @@ +{"Angioedema ": 2.6539705283655963, "Body temperature increased ": 2.7076601556616646, "Cellulitis ": 3.856011339805866, "Cold sweat ": 3.460811840194528, "Crying ": 20.44550760353357, "Cyanosis ": 12.376612908596352, "Decreased appetite ": 2.777760909669821, "Eczema ": 2.410617965282814, "Erythema ": 2.397858542507614, "Eye movement disorder ": 10.199011013669768, "Febrile convulsion ": 69.78941375597832, "Gait inability ": 2.21949700602106, "Guillain-Barre syndrome ": 3.5498812893631344, "Haematochezia ": 4.255025238763068, "Hyperpyrexia ": 6.059754661276945, "Hyporesponsive to stimuli ": 61.32549657098565, "Hypothermia ": 13.4248188900688, "Hypotonia ": 11.735787655751778, "Hypotonic-hyporesponsive episode ": 80.07405606071534, "Immunisation reaction ": 3.763094068200025, "Infantile vomiting ": 297.95322778250386, "Injection site mass ": 7.726266586601151, "Irritability ": 10.749402520194906, "Irritability postvaccinal ": 18.888237832198858, "Kawasaki's disease ": 93.7734614942848, "Lethargy ": 4.853299975916843, "Loss of consciousness ": 3.202554283668737, "Meningitis ": 12.117142794974749, "Meningococcal bacteraemia ": 447.5382783503141, "Pallor ": 14.245331492820604, "Paralysis ": 3.590123010712093, "Petechiae ": 4.397909738079209, "Posture abnormal ": 23.76643216495098, "Product administered to patient of inappropriate age ": 14.268787928159856, "Pyrexia ": 3.79542759923243, "Rash ": 2.2926588611246133, "Rash macular ": 3.6023462519664937, "Rash morbilliform ": 4.909259802355567, "Respiratory arrest ": 2.569335674791817, "Restlessness ": 2.401166784073336, "Seizure ": 3.867691781636057, "Somnolence ": 2.163550754731656, "Syncope ": 3.7714220368277056, "Tearfulness ": 12.311305309757472, "Unresponsive to stimuli ": 9.055974891140345, "Urticaria ": 2.8493186136188005, "Vaccination site erythema ": 3.959442749890447, "Vaccination site induration ": 12.242806762004076, "Vaccination site mass ": 19.94983584023073, "Vaccination site oedema ": 7.991036305563466, "Vaccination site reaction ": 2.962587909400165, "Vaccination site swelling ": 2.979605448560456, "Vomiting ": 2.693540825851686} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/169.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/169.json new file mode 100644 index 00000000000..2a21a31a377 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/169.json @@ -0,0 +1 @@ +{"Blood cholesterol increased ": 6.180819101429842, "Blood creatinine decreased ": 159.54988924297095, "Blood creatinine increased ": 2.8211783586784347, "Bradycardia ": 3.4062872234417187, "Cardiac disorder ": 4.409715635119716, "Drug interaction ": 2.094528464281381, "Emotional disorder ": 17.042091928144742, "Feeling abnormal ": 4.6862804188714735, "Flushing ": 4.442430610325446, "Gait disturbance ": 3.784012884400332, "Hallucination ": 2.919419191066829, "Hip fracture ": 20.60198940620528, "Hyperaemia ": 51.88735480816836, "Hyperkalaemia ": 3.559725561765743, "Hyponatraemia ": 4.863811378765752, "Joint effusion ": 30.172665544142905, "Muscle twitching ": 10.747460803875107, "Muscular weakness ": 3.302635869460995, "Oral candidiasis ": 12.170827291552945, "Post procedural infection ": 129.32191508716056} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/17.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/17.json new file mode 100644 index 00000000000..562ef46bc86 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/17.json @@ 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/170.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/170.json new file mode 100644 index 00000000000..59a82aa841e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/170.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 16.211473568022807, "Abnormal weight gain ": 13.905583323339515, "Abortion induced ": 4.250644590181727, "Accident at work ": 60.87521138170389, "Acquired immunodeficiency syndrome ": 23.28897853761737, "Adverse event ": 2.7364351129835174, "Affective disorder ": 8.379935378050146, "Anxiety disorder ": 3.982353311394032, "Benign prostatic hyperplasia ": 15.761002625669224, "Bipolar disorder ": 5.280026385650897, "Blood HIV RNA ": 128.9348046977465, "Blood HIV RNA increased ": 172.74621696273675, "Blood blister ": 8.257055944504613, "Blood creatinine increased ": 2.550198041659546, "Blood lactic acid increased ": 2.7151965260776745, "Blood triglycerides increased ": 6.129767437266305, "Bronchitis ": 2.0710222520168773, "CD4 lymphocytes decreased ": 124.22977397105107, "Carotid arteriosclerosis ": 30.269188311999528, "Cerebral toxoplasmosis ": 30.995252689560772, "Circumstance or information capable of leading to medication error ": 12.11422014400143, "Creatinine renal clearance decreased ": 3.012603968842698, "Cyst ": 4.530478312022907, "Dental caries ": 2.6212489157039336, "Depressed mood ": 2.037233620709862, "Depression ": 3.8598489202733943, "Dermatitis ": 7.073607594804571, "Diabetes mellitus ": 3.305771177309938, "Diffuse alopecia ": 14.41012687130484, "Drug ineffective ": 2.3654329302696686, "Drug resistance ": 13.496253773232944, "Drug resistance mutation ": 183.54765795258527, "Dupuytren's contracture ": 35.86342570000992, "Dyslipidaemia ": 4.884081244106118, "Dyspepsia ": 2.306119251792408, "Dysphagia ": 4.029437877438168, "Emotional disorder ": 2.010543519809912, "Endotracheal intubation ": 16.436345289081938, "Erectile dysfunction ": 4.050412169837435, "Face injury ": 7.775094238083694, "Family stress ": 326.2548304959832, "Fat tissue increased ": 18.385815114805084, "Gastrointestinal disorder ": 3.0949681250574987, "Gastrointestinal tube insertion ": 83.8861499345394, "Gastrostomy ": 39.71666788395807, "Genotype drug resistance test positive ": 115.6037006985006, "Gestational diabetes ": 5.749868437892848, "Glaucoma ": 2.201854598827318, "Glomerular filtration rate decreased ": 10.884422190208015, "Glycosylated haemoglobin increased ": 4.106038528650144, "Gonorrhoea ": 111.74457758253568, "Gynaecomastia ": 4.400034294832929, "HIV infection ": 30.24915229169567, "HIV test positive ": 41.80907631172655, "HIV viraemia ": 118.78717738244588, "HIV-associated neurocognitive disorder ": 33.207019396040145, "Haemodialysis ": 10.926470096349258, "Helicobacter infection ": 2.1989374407539364, "Hepatic cirrhosis ": 3.250563380271834, "Hepatic cytolysis ": 2.354104322739183, "Hepatic steatosis ": 4.072503965535388, "Hepatitis B ": 5.74237078064502, "Hepatitis B DNA increased ": 11.023349431784432, "Hepatitis B reactivation ": 3.928729798195381, "Hypercalcaemia ": 7.541415654461298, "Hypercholesterolaemia ": 2.1680425463694517, "Hyperemesis gravidarum ": 47.90612869601023, "Hyperlipidaemia ": 4.419280726988122, "Hyperphagia ": 9.106304444674963, "Hypersomnia ": 2.0124037593218724, "Hypertriglyceridaemia ": 2.345542398288093, "Immune reconstitution inflammatory syndrome ": 62.17207505972675, "Increased appetite ": 4.289390165041169, "Ingrown hair ": 73.6878714520271, "Initial insomnia ": 6.7353978046103, "Insomnia ": 2.9426045212257823, "Intentional dose omission ": 6.3712044032950805, "Intertrigo ": 195.03934183053948, "Intervertebral disc degeneration ": 2.508563819178304, "Joint noise ": 9.535371885678456, "Kaposi's sarcoma ": 30.559655366828103, "Lactic acidosis ": 2.818647919224698, "Libido decreased ": 3.1649080604128565, "Ligament sprain ": 19.833474889458245, "Lipids abnormal ": 57.20426184527183, "Lipodystrophy acquired ": 9.772942216336924, "Live birth ": 6.978214306370388, "Liver function test increased ": 3.3178096774942105, "Loss of libido ": 6.791091788636486, "Low density lipoprotein increased ": 6.782848910948265, "Lumbar spinal stenosis ": 48.03791963540094, "Lung consolidation ": 20.874198792914715, "Lymphoma ": 3.6713867640859537, "Major depression ": 3.869531464238956, "Maternal exposure during pregnancy ": 3.3975395285741725, "Mechanical ventilation ": 5.804577235091415, "Meningitis cryptococcal ": 22.12526967402916, "Menopausal symptoms ": 30.25483376445725, "Mental disorder ": 4.062789468605201, "Mental status changes ": 4.74743931081544, "Metabolic disorder ": 24.792700553421984, "Middle insomnia ": 2.039092749231868, "Miosis ": 2.1669781331918214, "Mitochondrial DNA mutation ": 106.42441620614947, "Monkeypox ": 572.2812317977036, "Muscle atrophy ": 3.983226531210247, "Mycobacterium avium complex infection ": 15.940841457075749, "Mycoplasma genitalium infection ": 1155.9796967217178, "Myositis ": 3.2123078701029257, "Nervous system disorder ": 7.323679230407762, "Neuropathy peripheral ": 2.100732525336884, "Neuropsychiatric syndrome ": 118.46683606821615, "Nightmare ": 8.013305430925737, "Obesity ": 3.6439446922268695, "Opportunistic infection ": 19.559388367292687, "Paranoia ": 2.364334584402473, "Pathogen resistance ": 2.5144235375035864, "Persecutory delusion ": 6.87463343559486, "Pigmentation disorder ": 14.009123986857192, "Pneumocystis jirovecii pneumonia ": 6.084671348336378, "Pneumomediastinum ": 19.300673001841798, "Pneumonia streptococcal ": 45.13149165628347, "Pneumothorax ": 2.04675400184223, "Poisoning deliberate ": 3.7420826116033674, "Premature delivery ": 3.368697788612041, "Product blister packaging issue ": 29.42146536340325, "Product package associated injury ": 21.230167513596108, "Product packaging difficult to open ": 40.79061362810873, "Product use complaint ": 5.0528863367305, "Progressive multifocal leukoencephalopathy ": 4.782743068794248, "Psychiatric symptom ": 2.997034679642722, "Rales ": 6.495677077113978, "Renal colic ": 8.771942670261758, "Renal impairment ": 2.327615898201357, "Rhonchi ": 21.339886093385932, "Scoliosis ": 3.682927665137964, "Skin lesion ": 2.11391998122753, "Sleep disorder ": 4.857128596363057, "Sleep terror ": 10.599539352906818, "Spinal stenosis ": 3.0894805104016254, "Squamous cell carcinoma ": 3.2673801541628475, "Suicidal ideation ": 2.8649128766169167, "Suspected counterfeit product ": 5.342464289449949, "Syphilis ": 36.58830183238787, "Tinea pedis ": 56.24260744027168, "Toxic skin eruption ": 2.094274620573904, "Treatment failure ": 2.8643513062480093, "Treatment noncompliance ": 15.8617401354794, "Trigeminal nerve disorder ": 25.901010519695184, "Tuberculosis ": 6.468261637296992, "Unevaluable event ": 3.511134094175433, "Viraemia ": 222.2101632400498, "Viral load ": 170.87287612535974, "Viral load abnormal ": 663.6979522012074, "Viral load decreased ": 137.51745744674574, "Viral load increased ": 128.68420443678886, "Viral mutation identified ": 17.591802484957203, "Virologic failure ": 29.66360819641498, "Weight increased ": 24.17852742027715, "Weight loss poor ": 14.856736575321465, "Wrong technique in product usage process ": 4.014739647276096} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/171.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/171.json new file mode 100644 index 00000000000..b3b0de4fd17 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/171.json @@ -0,0 +1 @@ +{"Corneal oedema ": 572.2240041111621, "Intraocular pressure increased ": 333.7598422419329} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/172.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/172.json new file mode 100644 index 00000000000..b3c04094149 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/172.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 3.0490634849604894, "Colitis ": 15.530351206102909, "Disease progression ": 3.22284175241883, "Liver disorder ": 8.394019310031123, "Malignant melanoma ": 46.72571709494515, "Malignant neoplasm progression ": 9.035119602991468, "Neoplasm progression ": 8.657878374988124, "Off label use ": 3.258467250835774, "Product use in unapproved indication ": 5.935070801449918, "Serous retinal detachment ": 313.3136554751918, "Uveitis ": 25.963781361970856, "Vision blurred ": 2.65054032262972} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/173.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/173.json new file mode 100644 index 00000000000..b1314758fff --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/173.json @@ -0,0 +1 @@ +{"Anaemia ": 6.236287167680149, "Aplasia pure red cell ": 172.36431590406747, "Disease progression ": 2.6595364504418875, "Drug ineffective ": 2.4356686940264782, "Dyspnoea exertional ": 5.943574659825215, "Dysuria ": 6.802686601984546, "Ejection fraction decreased ": 14.655123957676537, "Eosinophilia ": 8.870304500094988, "Face oedema ": 8.155972602707898, "Febrile bone marrow aplasia ": 95.85085367940256, "Generalised oedema ": 20.58629853871493, "Haemoglobin decreased ": 17.484827947962575, "Hyperkalaemia ": 4.1854908015195935, "Pruritus ": 3.5176137602039232, "Pulmonary embolism ": 2.3926110737733217, "Rash maculo-papular ": 6.885778303271618, "Therapy non-responder ": 29.646928610442718} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/174.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/174.json new 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/186.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/186.json new file mode 100644 index 00000000000..391e4364d06 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/186.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.7564731483093547, "Atrial fibrillation ": 2.0038012078612417, "Cardiac failure ": 5.970280361334661, "Cardiac failure congestive ": 2.5059774437944573, "Cardiomegaly ": 12.802095898522364, "Condition aggravated ": 4.218473327183254, "Cyanosis ": 6.182629087370977, "Disease progression ": 4.704927633410306, "Drug ineffective for unapproved indication ": 12.870863175247678, "Drug interaction ": 2.515000476448507, "Dyspepsia ": 3.4813260356856484, "Exposure during pregnancy ": 2.2915215939227864, "Fluid retention ": 7.329738405030459, "Flushing ": 2.3685452636759696, "General physical health deterioration ": 2.3440078165387006, "Haemoptysis 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10.766213735254556, "Red blood cell count decreased ": 2.492275087211099, "Renal disorder ": 3.429015322118524, "Renal impairment ": 3.570605202432416, "Second primary malignancy ": 28.95057316394313, "Sensory loss ": 3.422057776888627, "Skin ulcer ": 4.018673088317407, "Stress ": 2.7406052831799, "Transaminases increased ": 2.022107255253692, "Ulcer ": 5.0678119604874485, "Weight decreased ": 2.461932582747204, "White blood cell count abnormal ": 8.28320962830743, "White blood cell count increased ": 5.445098163171418} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/188.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/188.json new file mode 100644 index 00000000000..b71a78c51c7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/188.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.2044212826714547, "Blast crisis in myelogenous leukaemia ": 143.83841396040518, "Blood 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": 9.27105165551999, "Bradykinesia ": 20.57437389304109, "Breast cancer stage II ": 17.62389774736483, "Breast cancer stage III ": 7.2486668466569455, "Drug ineffective ": 5.67305900639578, "Drug ineffective for unapproved indication ": 73.13723531916911, "Drug intolerance ": 23.207020329253915, "Drug resistance ": 2.5934303984837475, "Dysphonia ": 33.19621117652444, "Endometriosis ": 13.42008441955809, "Exostosis ": 10.2498513317249, "Folliculitis ": 2.550730441051212, "Food intolerance ": 19.423978655216736, "Head discomfort ": 74.1577146490275, "Headache ": 2.273232320230348, "Hepatic cirrhosis ": 3.0957041641103524, "Hyperammonaemic encephalopathy ": 16.00685923621643, "Hyperhidrosis ": 7.286541101475322, "Hypersensitivity ": 7.832189868211626, "Joint stiffness ": 2.7210559583580967, "Laryngitis ": 9.51388159013472, "Lennox-Gastaut syndrome ": 195.5232187538583, "Lip dry ": 10.936227848000453, "Lower limb fracture ": 4.285149736620262, "Lupus vulgaris ": 49.29371591454608, "Mastoiditis ": 85.07329063963378, "Migraine ": 28.4761202693563, "Migraine with aura ": 18.85873440850666, "Mood altered ": 3.187024307882343, "Myoclonic epilepsy ": 20.20744794153688, "Myoclonus ": 2.5296490852367497, "Neck pain ": 29.085627103859597, "Nephrolithiasis ": 36.43819102619504, "Nightmare ": 43.24589284850268, "Off label use ": 8.275080026400827, "Orthostatic hypotension ": 2.2681518838587995, "Otitis media ": 19.618845686512465, "Pain ": 3.704221710221257, "Paranasal cyst ": 217.6383795944915, "Petit mal epilepsy ": 5.881226829385805, "Product use in unapproved indication ": 16.641283762609625, "Product used for unknown indication ": 90.84680576452529, "Sedation ": 78.85142360540652, "Stress ": 3.515337933710041, "Swelling face ": 23.827523545243032, "Swollen tongue ": 42.79880261636546, "Therapeutic product effect incomplete ": 3.913267650956037, "Therapeutic response decreased ": 2.9826001453295845, "Therapy non-responder ": 3.487984772207718, "Therapy partial responder ": 6.339146741001509, "Treatment failure ": 5.215984440898126, "Vascular malformation ": 140.1788960645248, "Visual field defect ": 5.700475956517559} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/19.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/19.json new file mode 100644 index 00000000000..50ee6b3dacc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/19.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.92553289480419, "Alanine aminotransferase abnormal ": 94.10219370372036, "Arthritis ": 8.015668489391434, "Atrial fibrillation ": 3.9002260637323785, "Blood pressure abnormal ": 16.221155519769955, "Blood pressure diastolic abnormal ": 126.10292480836006, "Blood pressure diastolic decreased ": 42.824865341921225, "Blood pressure fluctuation ": 10.003419313012758, "Blood pressure systolic abnormal ": 128.3011620091081, "Blood pressure systolic 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2.5442527299246827, "Limb injury ": 12.253353225594433, "Limb mass ": 62.08834775715734, "Liver function test abnormal ": 12.716323075861728, "Musculoskeletal pain ": 5.539037358927272, "Neuropathy peripheral ": 3.2670843270643526, "Oral herpes ": 11.519342555804696, "Osteitis ": 83.46835268608572, "Osteoarthritis ": 8.714316233681705, "Osteomyelitis ": 17.399752673986765, "Osteonecrosis of jaw ": 48.64531299490949, "Osteopenia ": 6.537883717501369, "Osteoporosis ": 3.124835017382656, "Pain ": 2.3953645926889715, "Pericarditis ": 3.342855518431429, "Pleural effusion ": 4.006768957930272, "Poor venous access ": 191.3726483021597, "Procedural pain ": 28.83017076200957, "Rectal prolapse ": 225.0546184347296, "Red blood cell sedimentation rate abnormal ": 62.00997749526741, "Rheumatoid arthritis ": 6.655821182683525, "Sinus tachycardia ": 11.970369250518496, "Sleep disorder ": 2.056634791318324, "Spinal stenosis ": 27.86975414761918, "Stress ": 6.108713715741348, "Thermal burn ": 42.750243205747225, "Vitamin D decreased ": 53.85487049570725} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/190.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/190.json new file mode 100644 index 00000000000..3769942434a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/190.json @@ -0,0 +1 @@ +{"Acne ": 3.6249476135339824, "Adrenal insufficiency ": 2.622236908451458, "Amylase increased ": 4.011982399454651, "Blood creatine phosphokinase increased ": 2.787053910458048, "Brain neoplasm ": 7.443312610076406, "Brain oedema ": 3.029499074691308, "Brain operation ": 31.109559251423097, "Carcinoembryonic antigen increased ": 13.05382402111739, "Cardiac dysfunction ": 10.987264599353784, "Central serous chorioretinopathy ": 22.94528027908625, "Cholestasis ": 2.4387481631134635, "Chorioretinitis ": 27.53591418825309, "Colitis ": 7.346358293903327, "Colitis 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00000000000..c963e58c702 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/191.json @@ -0,0 +1 @@ +{"Anaemia ": 2.677646493652403, "Disease progression ": 7.748357525772231, "Drug ineffective ": 2.0253043112566247, "Febrile neutropenia ": 22.86711427181714, "Hodgkin's disease ": 509.8437675637159, "Malignant neoplasm progression ": 12.169908275871409, "Myelosuppression ": 15.995376106483372, "Neuropathy peripheral ": 8.202021440140475, "Neutropenia ": 7.855211256921048, "Neutrophil count decreased ": 12.804708737605784, "Off label use ": 3.408813195096497, "Product use in unapproved indication ": 4.628148035202643, "Thrombocytopenia ": 2.928931560339056, "White blood cell count decreased ": 11.319192895109182} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/192.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/192.json new file mode 100644 index 00000000000..5be0d5e1102 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/192.json @@ -0,0 +1 @@ +{"Chronic obstructive pulmonary disease ": 141.20322855998197, "Pneumonia ": 11.132844809588155} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/193.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/193.json new file mode 100644 index 00000000000..1d8c9118db7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/193.json @@ -0,0 +1 @@ +{"Blood pressure decreased ": 9.944783703212, "Chest discomfort ": 2.948200604974316, "Dissociation ": 461.80251896243504, "Drug ineffective ": 3.8950456309289136, "Drug interaction ": 3.3219555573638004, "Electrocardiogram QT prolonged ": 9.149609123764314, "Hypomania ": 238.816437624049, "Mental disorder ": 33.24999593428197, "Off label use ": 5.778510015499896, "Schizophrenia ": 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--git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/195.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/195.json new file mode 100644 index 00000000000..a0d52c0a0bf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/195.json @@ -0,0 +1 @@ +{"Acute generalised exanthematous pustulosis ": 3.699357446072573, "Acute pulmonary oedema ": 18.01519279076917, "Acute respiratory failure ": 3.0509221317403896, "Adverse event ": 4.02970426153338, "Airway complication of anaesthesia ": 177.21617286771666, "Airway peak pressure increased ": 229.82135865159088, "Anaesthetic complication ": 31.648858202284764, "Anaphylactic reaction ": 48.95944933705384, "Anaphylactic shock ": 62.63059390038672, "Anaphylactoid reaction ": 44.80322535895784, "Anaphylactoid shock ": 36.34403319582919, "Angioedema ": 2.566544524063437, "Apnoea ": 10.293039919551331, "Arteriospasm coronary ": 41.88225720413606, "Aspiration ": 5.075995958779927, "Atrioventricular block ": 3.552249041341651, "Atrioventricular block complete ": 19.166788552108677, "Atrioventricular block second degree ": 16.316887435279643, "Blood pressure decreased ": 21.074956304267943, "Blood pressure systolic decreased ": 6.363081158175907, "Bradycardia ": 38.41641357843466, "Bronchospasm ": 55.96646119030744, "Cardiac arrest ": 23.45584766933434, "Cardio-respiratory arrest ": 6.101355923426213, "Cholestatic liver injury ": 24.540700753929915, "Circulatory collapse ": 4.7818131768192895, "Cyanosis ": 4.184890752666892, "Deafness neurosensory ": 7.270561107986666, "Delayed recovery from anaesthesia ": 37.42896680879122, "Depressed level of consciousness ": 3.628068049070933, "Disseminated intravascular coagulation ": 2.0630694988894915, "Drug hypersensitivity ": 3.659927077364237, "Drug reaction with eosinophilia and systemic symptoms ": 2.77440204496636, "Electrocardiogram ST segment depression ": 22.268281228545906, "Electrocardiogram ST 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during delivery ": 11.927981808903398, "Mechanical ventilation ": 22.86680617419127, "Movement disorder ": 2.127181872881548, "Muscle rigidity ": 7.334475203592546, "Muscle twitching ": 2.3660244586563715, "Negative pressure pulmonary oedema ": 354.81312716219105, "Neuromuscular block prolonged ": 287.7867726350917, "Normochromic normocytic anaemia ": 18.677798859335425, "Obstructive airways disorder ": 4.785719336500796, "Oxygen saturation decreased ": 15.043253080145272, "Papule ": 2.642705488493004, "Paralysis ": 5.215729583354633, "Pharyngeal oedema ": 6.427581111025683, "Pneumothorax ": 4.496556945590275, "Post procedural haemorrhage ": 8.741206586779095, "Prinzmetal angina ": 51.033546921024985, "Procedural nausea ": 60.408463051357, "Procedural vomiting ": 94.8049991961705, "Product administered to patient of inappropriate age ": 15.29805648294015, "Product quality issue ": 2.44255953154262, "Product storage error ": 2.182568284615693, "Product use issue ": 2.319835937484415, "Pulmonary oedema ": 8.729463476304744, "Pulseless electrical activity ": 52.31824740364951, "Recurrence of neuromuscular blockade ": 7064.441157482105, "Respiratory arrest ": 19.379620631153827, "Respiratory depression ": 6.538619963583229, "Respiratory disorder ": 2.1232046876738657, "Respiratory failure ": 3.797131711417471, "Resuscitation ": 17.914354974929932, "Shock ": 5.306605193289111, "Sinus arrest ": 12.18447378508978, "Sinus tachycardia ": 3.4081481656065704, "Supraventricular tachycardia ": 12.381290588296403, "Swelling of eyelid ": 3.498537152878082, "Tachycardia ": 3.1040630753613803, "Therapeutic product effect delayed ": 17.859906269226983, "Therapeutic product effect incomplete ": 2.1194846167129024, "Tongue oedema ": 3.0040916574661995, "Type I hypersensitivity ": 29.990195779020286, "Underdose ": 7.1574894919712015, "Upper airway obstruction ": 32.20391208796593, "Urticaria ": 3.9003159958816656, "Ventricular extrasystoles ": 3.839433302629269, "Ventricular fibrillation ": 16.16556455257251, "Ventricular tachycardia ": 7.08459421881965, "Wheezing ": 3.979043850495192, "Wrong product administered ": 2.595517953807057} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/196.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/196.json new file mode 100644 index 00000000000..d788eaf4cc8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/196.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 14.19134159769352, "Acute myocardial infarction ": 9.094788349856982, "Acute pulmonary oedema ": 3.3698092643563604, "Anaemia ": 4.796132870580524, "Angina pectoris ": 5.597011332411711, "Angina unstable ": 10.93581089931697, "Aortic dissection ": 5.596485783634826, "Apnoea ": 2.88808778465734, "Atrioventricular block ": 8.102148052044232, "Atrioventricular block complete ": 20.437484510128336, "Atrioventricular block second degree ": 12.92739528985086, "Basal ganglia haemorrhage ": 17.689941080916757, "Blood loss anaemia ": 20.400359056318443, "Blood potassium increased ": 2.497932622221499, "Blood uric acid increased ": 11.002778726767062, "Bradyarrhythmia ": 7.455671547734895, "Bradycardia ": 5.438509389358259, "Brain herniation ": 11.383096145464124, "Cardiac arrest ": 3.0070814782614907, "Cardiac failure ": 2.4516980759958487, "Cardiac tamponade ": 13.20432294678302, "Cardiac ventricular thrombosis ": 4.67592896320986, "Cardiogenic shock ": 4.325679497219267, "Central sleep apnoea syndrome ": 363.1932656504565, "Cerebellar haemorrhage ": 5.5266718270642325, "Cerebral haematoma ": 28.692130836523496, "Cerebral haemorrhage ": 16.28005971916398, "Cerebral mass effect ": 22.45867772055913, "Cheyne-Stokes respiration ": 44.17474893974636, "Choking ": 2.014341742189898, "Cholestasis ": 2.148843069253679, "Conjunctival haemorrhage ": 7.081569906454659, "Contusion ": 7.249762545711899, "Coronary artery occlusion ": 4.728363378456091, "Coronary artery restenosis ": 43.64041067992903, "Coronary artery stenosis ": 15.429244526010958, "Coronary artery thrombosis ": 10.927726403589896, "Craniocerebral injury ": 6.373055062800956, "Cystitis haemorrhagic ": 4.108759857217241, "Device occlusion ": 11.192878599238936, "Diastolic dysfunction ": 5.564811636177595, "Diverticulum intestinal haemorrhagic ": 6.518462666768117, "Drug interaction ": 3.047272505639657, "Duodenal ulcer ": 7.862181802600708, "Duodenal ulcer haemorrhage ": 5.752822123621036, "Dyspnoea ": 8.702276985568632, "Dyspnoea at rest ": 57.47154940628745, "Dyspnoea exertional ": 7.623489393582469, "Dyspnoea paroxysmal nocturnal ": 31.657439989325244, "Ear haemorrhage ": 14.26053084719862, "Ecchymosis ": 29.848110851684037, "Ejection fraction decreased ": 3.424908506215968, "Electrocardiogram abnormal ": 4.66264249765424, "Eosinophilia ": 2.9476613279395525, "Epistaxis ": 20.75962277496496, "Erosive duodenitis ": 17.63518731158939, "Extravasation blood ": 44.204051593416416, "Eye haemorrhage ": 6.047507105227237, "Facial paresis ": 2.1393421651265827, "Faeces discoloured ": 3.233995014103168, "Gastric haemorrhage ": 29.407278115328136, "Gastric ulcer ": 4.592203059087188, "Gastric ulcer haemorrhage ": 10.162808738602664, "Gastritis ": 2.0756034901804195, "Gastritis erosive ": 7.441086493482119, "Gastrointestinal haemorrhage ": 12.684666894444588, "Genital haemorrhage ": 6.435570101767847, "Gingival bleeding ": 12.13186677416315, "Gout ": 11.211158014684928, "Haemarthrosis ": 2.929651493849026, "Haematemesis ": 7.436814392953587, "Haematochezia ": 2.9546280004633725, "Haematocrit decreased ": 4.875630443506753, "Haematoma ": 13.610425515700634, "Haematoma muscle ": 11.425673710578712, "Haematuria ": 16.454834224014114, "Haemoglobin decreased ": 2.987430651233945, "Haemoperitoneum ": 9.207245743825474, "Haemoptysis ": 9.466953595859737, "Haemorrhage ": 7.224607059288683, "Haemorrhage intracranial ": 19.74181988470945, "Haemorrhage subcutaneous ": 2.916010513658188, "Haemorrhage urinary tract ": 10.087832117561074, "Haemorrhagic diathesis ": 8.426369520727583, "Haemorrhagic stroke ": 18.01485207365553, "Haemorrhagic transformation stroke ": 19.48463768094077, "Haemorrhoidal haemorrhage ": 8.059538896035678, "Haemorrhoids ": 2.138532505839746, "Haemothorax ": 5.188762209688972, "Heart rate decreased ": 2.0320515213203643, "Hemiplegia ": 2.1584113307613486, "Hepatic cytolysis ": 3.1929362253178963, "Hepatitis cholestatic ": 2.300149278070388, "Hepatitis toxic ": 4.820094858388861, "Hyperlipidaemia ": 2.004781112576835, "Hyperuricaemia ": 8.397172580407103, "Hyperventilation ": 2.373989795856883, "Increased tendency to bruise ": 4.817069845158555, "Infarction ": 6.463185841828418, "International normalised ratio decreased ": 3.1884337624615133, "Intestinal haemorrhage ": 20.57750518979222, "Intracranial haematoma ": 26.691842252699665, "Intraventricular haemorrhage ": 11.893068078082251, "Iron deficiency anaemia ": 6.693318509779702, "Ischaemic cardiomyopathy ": 5.461943434486682, "Ischaemic stroke ": 3.3788468281178163, "Large intestinal haemorrhage ": 15.56491568436153, "Left ventricular dysfunction ": 2.260032367703613, "Lower gastrointestinal haemorrhage ": 9.76505367420426, "Melaena ": 20.4410477782199, "Mitral valve incompetence ": 5.302599318604846, "Mouth haemorrhage ": 2.849301697700111, "Muscle haemorrhage ": 4.548565586421685, "Myocardial infarction ": 3.3876797851558, "Myocardial ischaemia ": 2.2256297827583778, "Nocturnal dyspnoea ": 47.27474268299163, "Orthopnoea ": 8.999511539246154, "Pancreatic carcinoma metastatic ": 4.064899658670651, "Pericardial haemorrhage ": 32.62433302234234, "Petechiae ": 6.176442973481381, "Post procedural haematoma ": 12.544621739624002, "Post procedural haemorrhage ": 11.321105043922062, "Procedural haemorrhage ": 14.546583922985786, "Product residue present ": 5.024754561996318, "Product solubility abnormal ": 8.046603787996911, "Pulmonary haemorrhage ": 8.164215568312883, "Purpura ": 3.613179201347502, "Rash maculo-papular ": 4.692352370647558, "Rectal haemorrhage ": 13.95423685329321, "Retinal haemorrhage ": 3.5064055797714837, "Retroperitoneal haematoma ": 6.06720148205852, "Rhabdomyolysis ": 4.015422845178487, "Sense of oppression ": 4.6401751650130505, "Shock haemorrhagic ": 13.528784758742788, "Sinoatrial block ": 63.491637732988245, "Sinus arrest ": 35.88903264663028, "Sinus bradycardia ": 7.43863377015445, "Skin haemorrhage ": 6.427144795444262, "Sleep apnoea syndrome ": 8.144419603436068, "Spontaneous haematoma ": 17.18859803198686, "Subarachnoid haemorrhage ": 7.219619929664407, "Subcutaneous haematoma ": 13.875458546306543, "Subdural haematoma ": 18.47948232333048, "Subdural haemorrhage ": 6.94048916646107, "Suffocation feeling ": 7.012223447903515, "Supraventricular extrasystoles ": 4.25169353822942, "Therapy cessation ": 10.719597811955936, "Thrombocytopenia ": 2.0601841267370844, "Thrombosis in device ": 25.49245771222767, "Tongue haemorrhage ": 15.563762163501735, "Toxic skin eruption ": 2.7787082755835786, "Tricuspid valve incompetence ": 6.019126721289351, "Troponin increased ": 3.0822479090081094, "Upper gastrointestinal haemorrhage ": 6.997420650254858, "Urinary bladder haemorrhage ": 13.228543319656064, "Urine abnormality ": 7.024387476827147, "Vascular stent stenosis ": 82.11066654946829, "Vascular stent thrombosis ": 158.4461983929955, "Ventricular asystole ": 115.40500400675012, "Ventricular extrasystoles ": 2.075280935693549, "Wound haemorrhage ": 12.18563227308595} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/197.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/197.json new file mode 100644 index 00000000000..75571d420a8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/197.json @@ -0,0 +1 @@ +{"Muscular weakness ": 28.959563671864228, "Orthostatic hypotension ": 143.7333834452935, "Presyncope ": 62.267975873994246} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/198.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/198.json new file mode 100644 index 00000000000..7b30082e8b9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/198.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.6173348880947844, "Confusional state ": 2.592223063147274, "Drug ineffective ": 2.72054187951502, "Eye irritation ": 67.0115553044586, "Eye pain ": 12.531858574035065, "Intraocular pressure increased ": 183.10262380635325, "Ocular hyperaemia ": 30.48440017252974, "Somnolence ": 3.783756865054755, "Toxicity to various agents ": 3.4608334187773164, "Vision blurred ": 4.520321914987699} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/199.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/199.json new file mode 100644 index 00000000000..ee55609cb1b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/199.json @@ -0,0 +1 @@ +{"Abdominal pain upper ": 2.032781047349109, "Abnormal dreams ": 14.619609380843826, "Abnormal weight gain ": 3.649637442603828, "Accommodation disorder ": 7.461937364148074, "Acne ": 3.3150926413451027, "Aggression ": 6.06833918123479, "Agitation ": 5.069031777480803, "Akathisia ": 5.561918901569084, "Alcohol interaction ": 6.146183776793818, "Anger ": 4.9298653301322455, "Anorgasmia ": 50.53299850638077, "Anxiety ": 4.619317314188294, "Apathy ": 4.9283939953229, "Appetite disorder ": 2.4859069152567117, "Binge eating ": 24.504277329499896, "Bipolar I disorder ": 8.610737689359066, "Blood prolactin increased ": 13.212266944216598, "Bradykinesia ": 4.544980697167464, "Bradyphrenia ": 2.543351216056098, "Bruxism ": 28.71575180135699, "Circumstance or information capable of leading to medication error ": 4.739493922506395, "Completed suicide ": 2.8416648385783367, "Constipation ": 2.6762746457250555, "Contusion ": 2.0100393669967267, "Crying ": 4.961053742186953, "Daydreaming ": 6.370097728739999, "Depersonalisation/derealisation disorder ": 12.237684036519497, "Depressed mood ": 4.078491582845115, "Depression ": 2.447345912842502, "Depressive symptom ": 6.700927110910641, "Derealisation ": 26.29518250904418, "Dissociation ": 6.12954912628522, "Disturbance in sexual arousal ": 13.768902315861965, "Dry eye ": 2.8256344247801564, "Dry mouth ": 2.2927465522187167, "Dyspepsia ": 3.215723570659224, "Ecchymosis ": 4.904730417048333, "Ejaculation delayed ": 42.90338365939984, "Ejaculation disorder ": 5.439707231671068, "Ejaculation failure ": 6.717960593777849, "Electric shock sensation ": 4.5883350338775735, "Electrocardiogram QT prolonged ": 3.0106942767589344, "Emotional poverty ": 8.21440193284497, "Energy increased ": 4.85772159000177, "Erectile dysfunction ": 5.4122021341339375, "Eructation ": 2.308912628514747, "Euphoric mood ": 2.3286922430995203, "Fear ": 3.4336967375575886, "Feeling abnormal ": 3.724847140827564, "Feeling drunk ": 3.1518764079806614, "Feeling of despair ": 6.254906620698407, "Flatulence ": 2.3325202089952977, "Food craving ": 7.71790633905546, "Formication ": 3.198366619658688, "Galactorrhoea ": 4.601627345912456, "Gastrointestinal pain ": 2.7978279130333235, "Genital hypoaesthesia ": 18.311069581603167, "Haematoma ": 2.219768101709217, "Hallucination, auditory ": 3.147963428973497, "Head discomfort ": 2.726704514541335, "Homicidal ideation ": 4.141315549519621, "Hot flush ": 2.956215049062436, "Hunger ": 11.806560583145044, "Hyperhidrosis ": 2.3676515431707954, "Hypernatraemia ": 2.136542175621704, "Hyperprolactinaemia ": 8.791477009448968, "Hypersomnia ": 2.323936572281208, "Hypomania ": 16.014805547764624, "Hyponatraemia ": 3.923799953694836, "Impulsive behaviour ": 6.137068463420575, "Inappropriate antidiuretic hormone secretion ": 3.569476725042221, "Increased appetite ": 10.064717422334356, "Increased tendency to bruise ": 3.0410156606306, "Indifference ": 14.373453475273353, "Initial insomnia ": 8.705332722646437, "Insomnia ": 3.288150674753925, "Intentional overdose ": 2.5467565856706247, "Intentional self-injury ": 5.136491299394668, "Intestinal haemorrhage ": 2.372153769988862, "Intraocular pressure increased ": 2.179795843710559, "Irritability ": 5.672481692463814, "Libido decreased ": 23.455325710609827, "Libido increased ": 7.98195071012703, "Logorrhoea ": 6.135639487946842, "Loss of libido ": 10.329641100706752, "Major depression ": 5.2675713168562375, "Mania ": 9.3049790640852, "Mental fatigue ": 4.009657135944759, "Middle insomnia ": 3.369377829495865, "Mood altered ": 3.729614605955202, "Mood swings ": 2.4931073899653287, "Motion sickness ": 6.370097728739999, "Muscle tightness ": 2.632166779774327, "Muscle twitching ": 2.1542976905779208, "Mydriasis ": 3.3979059289520803, "Nausea ": 3.9446164944480167, "Negative thoughts ": 25.698832995465622, "Nervousness ": 4.313540760896908, "Night sweats ": 6.325316967404075, "Nightmare ": 9.05262022820338, "Obsessive thoughts ": 9.956686754305707, "Orgasm abnormal ": 43.18643723930584, "Overdose ": 2.0170525421968275, "Panic attack ": 3.93591986177056, "Panic disorder ": 2.914758262985242, "Panic reaction ": 3.175111381907692, "Persecutory delusion ": 3.43739688411783, "Photopsia ": 2.167606164064148, "Poisoning deliberate ": 3.4187120160276314, "Poor quality sleep ": 3.938763264138833, "Pregnancy ": 8.009044031771037, "Prescribed overdose ": 4.434573670795789, "Prescribed underdose ": 2.0943634386167918, "Product administered to patient of inappropriate age ": 4.60572362910094, "Product use in unapproved indication ": 4.536541257657147, "Pruritus ": 5.376291387266709, "Psychomotor 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response unexpected ": 3.3631327178134267, "Therapy cessation ": 18.17366649136578, "Therapy change ": 6.554115589375809, "Thinking abnormal ": 4.233179924806692, "Tic ": 7.744349881724241, "Tinnitus ": 2.011666935494608, "Treatment noncompliance ": 2.8999430864864286, "Tremor ": 2.187746837964087, "Trismus ": 2.0073746606918803, "Underdose ": 4.336780606208564, "Urinary retention ": 2.5784244379528025, "Vertigo ": 2.9199352668768874, "Vomiting ": 2.7074595658670733, "Weight increased ": 4.703587653345733, "Withdrawal syndrome ": 3.2685492571098336, "Wrong patient ": 27.577075817966666, "Wrong technique in product usage process ": 5.63108858441618} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/2.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/2.json new file mode 100644 index 00000000000..0e700f7bb25 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/2.json @@ -0,0 +1 @@ +{"Abdominal lymphadenopathy ": 13.045411982848195, "Abdominal mass ": 4.55206955826119, "Acute abdomen ": 4.209149135288143, "Adjustment disorder with depressed mood ": 4.237392635996414, "Asthma ": 11.18705619156061, "Atypical mycobacterial infection ": 6.40049620029478, "Autoimmune disorder ": 2.074002188302761, "Back pain ": 4.389003158639491, "Blood HIV RNA increased ": 25.67870412641772, "Blood bicarbonate decreased ": 2.735628081751657, "Blood cholesterol increased ": 2.265947060175652, "Blood lactic acid increased ": 5.990125632948553, "Blood triglycerides increased ": 4.88779787963303, "Bone erosion ": 4.959304350083734, "Breast abscess ": 8.032117069749779, "Breast cancer stage II ": 9.520238510807271, "Bursitis ": 47.20459823749535, "CD4 lymphocytes abnormal ": 25.96849687412544, "CD4 lymphocytes decreased ": 16.693340216124966, "CSF HIV escape syndrome ": 21.08616618887081, "Cachexia ": 5.432932494579837, "Cardiothoracic ratio increased ": 92.33324993520672, "Cerebral toxoplasmosis ": 15.375319019851752, "Chorea ": 3.7998022292620703, "Coeliac disease ": 79.09586377480385, "Constipation ": 6.056210504784032, "Contraindicated product administered ": 12.615542890687712, "Contrast media allergy ": 16.890621327361735, "Cryptosporidiosis infection ": 40.31127095948433, "Cytomegalovirus chorioretinitis ": 8.867005244954214, "Cytomegalovirus oesophagitis ": 27.96341927510422, "Decreased immune responsiveness ": 21.23767603914714, "Depressive symptom ": 2.340914897702409, "Diplopia ": 5.919992515891461, "Disseminated mycobacterium avium complex infection ": 69.60096594591275, "Drug hypersensitivity ": 8.931655246947033, "Drug intolerance ": 9.14315800120726, "Drug level below therapeutic ": 2.100719136037982, "Drug resistance ": 8.986599769085734, "Dysdiadochokinesis ": 17.0516850194585, "Dyslipidaemia ": 10.37914977592417, "Erythema ": 3.145635412384758, "Exposure during pregnancy ": 21.520575829574344, "Eyelid ptosis ": 22.46328883559437, "Facial wasting ": 31.997446216782944, "Fanconi syndrome ": 4.361520189598277, "Fat redistribution ": 54.17487555254509, "Fat tissue increased ": 12.454398859117411, "Fluid retention ": 33.842645036699935, "Foetal death ": 125.86364401362368, "Food allergy ": 240.7774194936877, "Genotype drug resistance test positive ": 4.022235736866002, "Glucose tolerance impaired ": 5.069443730099772, "Glycosuria ": 3.383961996854826, "HIV infection ": 12.6857707366339, "HIV-associated neurocognitive disorder ": 40.65245686934084, "Hepatic cirrhosis ": 2.746889785944175, "Hepatic enzyme increased ": 16.164598524776167, "Hepatic necrosis ": 2.747350681839932, "Hepatosplenomegaly ": 4.62450283413216, "High density lipoprotein decreased ": 4.3398256019239785, "Hyperbilirubinaemia ": 2.189000727463703, "Hypercholesterolaemia ": 2.5043014690160077, "Hyperhidrosis ": 6.291607386652432, "Hyperlactacidaemia ": 6.503108083219105, "Hyperphagia ": 3.801172835424252, "Hypersensitivity ": 6.378976133651239, "Hypertension ": 5.58638880782433, "Hypertriglyceridaemia ": 5.814932666104827, "Hypophosphataemia ": 3.717831182234173, "Ileal ulcer ": 9.03149706490749, "Immune reconstitution inflammatory syndrome ": 17.352714529019355, "Immunodeficiency ": 161.58609277409082, "Impetigo ": 8.16939694290088, "Infection ": 8.592568638456447, "Infusion related reaction ": 24.46678274043601, "Intentional product misuse ": 15.989563109724989, "Intra-abdominal haematoma ": 4.193291201577518, "Joint swelling ": 12.71982779552135, "Kaposi's sarcoma ": 9.935784191756234, "Lactic acidosis ": 2.256909516030749, "Lip discolouration ": 8.50009195042409, "Lip erosion ": 8.871796013938816, "Lipids abnormal ": 10.272007388770064, "Lipoatrophy ": 46.42425179826252, "Lipodystrophy acquired ": 65.03054498160915, "Lipoedema ": 18.16045255675414, "Live birth ": 2.278848749431539, "Low density lipoprotein increased ": 6.529795958369237, "Lymphoedema ": 2.0673110052091954, "Magnetic resonance imaging head abnormal ": 3.2284729614290035, "Maternal exposure before pregnancy ": 6.627569793842597, "Maternal exposure during pregnancy ": 3.212953764124815, "Meningitis viral ": 7.782808416034403, "Metastatic malignant melanoma ": 2.146734443215766, "Mitochondrial cytopathy ": 15.408894107948033, "Mitochondrial myopathy ": 154.91757398474897, "Mitochondrial toxicity ": 169.22159041294174, "Multiple-drug resistance ": 9.396463745113849, "Muscle haemorrhage ": 3.1421042455548305, "Mycobacterium avium complex infection ": 4.033079831110975, "Mycobacterium test positive ": 28.265747711225867, "Nail discolouration ": 3.662884932648735, "Nephropathy toxic ": 2.357228084229724, "Neurological symptom ": 2.1239278787773963, "Obliterative bronchiolitis ": 13.102626038528143, "Oesophageal candidiasis ": 9.745763986665612, "Off label use ": 2.4683448679906657, "Ophthalmoplegia ": 5.394833940515004, "Oral candidiasis ": 2.075965350732973, "Osteochondrosis ": 7.523871228005273, "Overdose ": 8.134701076405351, "Pain ": 2.175452404913429, "Pathogen resistance ": 30.04171271939711, "Pelvic inflammatory disease ": 12.334426810172763, "Pneumocystis jirovecii infection ": 7.609767410855049, "Polymerase chain reaction ": 44.75061526696715, "Portal hypertension ": 4.956103283268751, "Premature labour ": 2.6015549874251267, "Prescribed overdose ": 53.5035246367101, "Product use issue ": 11.108501861523091, "Progressive external ophthalmoplegia ": 1506.060606607389, "Progressive multifocal leukoencephalopathy ": 4.986634574696754, "Psoriasis ": 22.82069497717423, "Pulmonary tuberculosis ": 4.683215957035845, "Rash ": 2.771475918095327, "Rash erythematous ": 24.002935111778584, "Renal function test abnormal ": 2.818740823808979, "Renal hypoplasia ": 24.746920393446317, "Renal tubular dysfunction ": 4.546955439109031, "Rheumatoid arthritis ": 13.68568399991304, "Sleep terror ": 2.150067382438213, "Superinfection bacterial ": 23.86035221745633, "Susac's syndrome ": 65.91390191458981, "Temperature regulation disorder ": 188.0771604736076, "Thrombocytopenia ": 7.725832481719602, "Toxoplasmosis ": 6.091908032087636, "Treatment failure ": 15.659686250359382, "Treatment noncompliance ": 5.69494683181208, "Upper respiratory tract infection ": 68.09805521754512, "Urine abnormality ": 2.0456032338440244, "Varicocele ": 16.96637215021089, "Viraemia ": 8.725279691354764, "Viral load increased ": 4.006606114955514, "Viral mutation identified ": 77.8069111877787, "Virologic failure ": 50.577737318825946} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/20.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/20.json new file mode 100644 index 00000000000..4d13fd0988e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/20.json @@ -0,0 +1 @@ +{"Activated partial thromboplastin time prolonged ": 9.794300711062869, "Analgesic therapy ": 41.7137727036254, "Antacid therapy ": 70.54966664321147, "Anticoagulant therapy ": 42.79248108704672, "Aortic stenosis ": 15.788116947577956, "Appendicitis ": 5.725439129869816, "Appendicolith ": 18.89066446471517, "Aspiration ": 6.722209175374538, "Asthma ": 16.034088047566755, "Asthma-chronic obstructive pulmonary disease overlap syndrome ": 1026.0800915136883, "Ataxia ": 17.626057577583772, "Atrial fibrillation ": 3.682160639153183, "Bacterial infection ": 4.561052833094216, "Benign prostatic hyperplasia ": 11.92723072463793, "Blood bilirubin increased ": 13.905472518328969, "Blood calcium increased ": 9.75717599082466, "Blood test abnormal ": 13.871090054510477, "Breast conserving surgery ": 133.00163975369662, "Breath sounds abnormal ": 69.76869441116006, "Bronchial obstruction ": 209.5070872558104, "Bronchial wall thickening ": 160.32214726127918, "Bronchiectasis ": 141.1567129153049, "Bronchiolitis ": 16.184627751824355, "Bronchopulmonary aspergillosis allergic ": 72.1848462799333, "Cardiac murmur ": 60.81870293394235, "Cardiogenic shock ": 3.63159670714588, "Carotid arteriosclerosis ": 69.48812564852915, "Cataract ": 10.95899860812604, "Cellulitis ": 3.005973076695175, "Cholelithiasis ": 24.42525250159686, "Chronic obstructive pulmonary disease ": 29.154484678147117, "Chronic sinusitis ": 20.93627173504365, "Condition aggravated ": 4.230613060217498, "Coronary artery bypass ": 51.48872669795927, "Cough ": 2.084997427364024, "Crepitations ": 15.79355590154366, "Crohn's disease ": 2.3477185887780525, "Dermatitis atopic ": 92.34949312126048, "Dupuytren's contracture ": 82.26474012607873, "Dupuytren's contracture operation ": 4289.238193960354, "Dyspepsia ": 5.982304367531809, "Dysphagia ": 5.144541199056696, "Dyspnoea ": 2.214707649877924, "Dyspnoea exertional ": 11.156041974721877, "Emphysema ": 35.37101046229918, "Eosinophil count increased ": 11.046773925916243, "Full blood count abnormal ": 13.226810655026258, "Fungal disease carrier ": 3630.822227419112, "Gastroenteritis ": 31.08316455881353, "Gastrooesophageal reflux disease ": 10.287800028280795, "Granuloma ": 23.244855531122948, "Graves' disease ": 12.300312738030945, "Haemoptysis ": 2.286225686888364, "Hepatic enzyme increased ": 6.53294544579161, "Hepatotoxicity ": 21.478130648738183, "Hypercapnia ": 87.65943224161082, "Hypertension ": 2.0391543636049145, "Hypomania ": 115.1590019708789, "Hypothyroidism ": 2.0899723832883224, "Ill-defined disorder ": 3.8833784063394505, "Impaired quality of life ": 11.92162497011097, "Inguinal hernia repair ": 924.4685547655546, "Jaundice cholestatic ": 100.8431385813956, "Loss of personal independence in daily activities ": 9.263379861637183, "Lower respiratory tract infection ": 5.4037397425142055, "Lung diffusion disorder ": 1409.8429305547263, "Lung diffusion test decreased ": 155.189601036973, "Lung disorder ": 7.157501990190728, "Lung neoplasm ": 206.0748539316517, "Lung neoplasm malignant ": 21.55655238078973, "Meniere's disease ": 34.264617464400864, "Mycobacterium test positive ": 272.05132804874165, "Nasal congestion ": 7.64959702258826, "Nasal polyps ": 140.08611178974064, "Nephrectomy ": 38.63190251255492, "No adverse event ": 2.033384056312953, "Nocturnal dyspnoea ": 102.4710127386318, "Obstruction ": 37.10626431864435, "Obstructive airways disorder ": 38.78514261709207, "Oedema peripheral ": 5.260170690109287, "Oral candidiasis ": 5.240636219464246, "Oropharyngeal candidiasis ": 342.6936893694759, "Oropharyngeal discomfort ": 22.966397516323312, "Osteonecrosis of jaw ": 17.730997735917917, "Pneumonia ": 4.887498549939374, "Productive cough ": 12.673877489259858, "Psychotic disorder ": 17.783332048865734, "Pulmonary mass ": 9.542625971180897, "Renal cyst ": 9.99700219557947, "Respiratory disorder ": 13.193316309498613, "Respiratory symptom ": 41.88759750196953, "Rhinitis allergic ": 73.9618636737396, "Sarcoidosis ": 92.18287781947332, "Schizophrenia ": 68.72433453293026, "Sinus disorder ": 20.17617332845585, "Sinus pain ": 15.256119622958796, "Sinusitis ": 2.639619963303937, "Sleep disorder due to a general medical condition ": 42.458103823346725, "Sputum discoloured ": 25.707633823946264, "Sputum purulent ": 167.39246541651318, "Stenotrophomonas infection ": 263.0032296998307, "Symptom recurrence ": 75.6748400105427, "Therapeutic product effect incomplete ": 11.954819182696554, "Therapy cessation ": 43.81347348211298, "Therapy interrupted ": 34.8688141095107, "Total lung capacity increased ": 1487.0384993080331, "Type 2 diabetes mellitus ": 19.028015269109563, "Upper respiratory tract infection ": 5.824487494924433, "Upper-airway cough syndrome ": 17.52272997128199, "Ventricular hypokinesia ": 94.36227366591687, "Vital capacity decreased ": 92.33591239843228, "Weight increased ": 4.775470346259801, "Wheezing ": 29.2749140088134} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/200.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/200.json new file mode 100644 index 00000000000..70f06efc207 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/200.json @@ -0,0 +1 @@ +{"Intraocular pressure increased ": 184.02015038649944} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/201.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/201.json new file mode 100644 index 00000000000..ab43187e4cf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/201.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 16.6327666826383, "Adverse drug reaction ": 7.406526535955066, "Affective disorder ": 15.975556950926018, "Aggression ": 13.718824718970282, "Anger ": 8.412027317854058, "Anticonvulsant drug level increased ": 53.10643467084547, "Behaviour disorder ": 31.83180048056962, "Coagulopathy ": 11.621960265885397, "Cognitive disorder ": 11.773118964915284, "Delirium ": 2.9891997513517103, "Depressed mood ": 5.250185683210288, "Depression ": 3.860691487296666, "Drug ineffective ": 3.706601759352004, "Drug ineffective for unapproved indication ": 19.57758478632129, "Drug intolerance ": 3.0202577624951927, "Drug resistance ": 9.846605225472588, "Dysarthria ": 3.353894036007678, "Dystonia ": 7.855907506312775, "Epilepsy ": 11.911218636710496, "Exposure during pregnancy ": 3.41206712951712, "Foetal exposure during pregnancy ": 2.727986055011248, "Gait disturbance ": 2.176449379460503, "Generalised tonic-clonic seizure ": 8.376903608315061, "Gingival disorder ": 47.87628306976799, "Hallucination ": 4.337772292008388, "Hallucination, visual ": 4.354156378080129, "Hyponatraemia ": 3.1231792000907967, "Intestinal atresia ": 1301.3554673539454, "Irritability ": 9.979120438565484, "Maternal exposure before pregnancy ": 55.54997841708654, "Maternal exposure during breast feeding ": 31.63918674749975, "Maternal exposure during pregnancy ": 13.402411002774071, "Memory impairment ": 6.0700529536339065, "Mood swings ": 8.259207953150085, "Multiple-drug resistance ": 383.9333592629885, "Myoclonic epilepsy ": 80.28682712562556, "Myoclonus ": 12.946037358036394, "Nephrolithiasis ": 2.760119299145742, "Off label use ": 7.778001872383929, "Overdose ": 9.244613032529807, "Oxygen saturation decreased ": 2.0226916491779696, "Partial seizures ": 13.619399023248173, "Partial seizures with secondary generalisation ": 610.7360466308605, "Patent ductus arteriosus ": 53.23991995776781, "Petit mal epilepsy ": 23.244622915869808, "Postictal paralysis ": 345.63629709145465, "Premature baby ": 11.030295800604376, "Premature delivery ": 24.3147215911612, "Prescribed overdose ": 4.52465246155034, "Product use in unapproved indication ": 2.515080837778473, "Product use issue ": 3.796214371767524, "Psychotic disorder ": 3.146909279314742, "Pulmonary haemorrhage ": 17.43455959639538, "Respiratory arrest ": 3.03289447280678, "Salivary hypersecretion ": 9.206596484649689, "Seizure ": 16.780753532714236, "Somnolence ": 3.6738898939732985, "Speech disorder ": 2.9433795418342923, "Status epilepticus ": 79.90432061527258, "Suicidal ideation ": 5.3183167014938695, "Therapeutic product effect incomplete ": 2.8306722230930075, "Therapeutic product ineffective for unapproved indication ": 625.9010999964784, "Therapeutic response unexpected ": 12.308380398785625, "Therapy non-responder ": 3.3030826995273275, "Treatment failure ": 2.2359148514497305, "Underdose ": 5.9146100755234645, "Weight increased ": 4.52689709748678} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/202.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/202.json new file mode 100644 index 00000000000..5b479929fd8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/202.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 4.2286544214840704, "Adverse drug reaction ": 7.657926244819743, "Adverse event ": 4.620994882885323, "Affective disorder ": 48.848659447160486, "Aggression ": 21.39616270142542, "Agitation ": 3.67304783014517, "Anger ": 14.593799580341882, "Anxiety ": 2.6102226933160275, "Apathy ": 4.902148692531389, "Aphasia ": 2.0319974394952047, "Ataxia ": 2.857977774886954, "Atonic seizures ": 65.32405116475624, "Aura ": 86.71754002694297, "Balance disorder ": 3.756276233966533, "Behaviour disorder ": 28.10895719829128, "Caesarean section ": 6.80543562182607, "Change in seizure presentation ": 211.97863648775075, "Cognitive disorder ": 6.431018476859681, "Crying ": 2.861832751141752, "Depressed mood ": 4.787762008082611, "Depression ": 4.602895454458997, "Diplopia ": 4.293936965457269, "Disturbance in attention ": 2.0470913145914893, "Drug ineffective ": 2.0195442651839968, "Drug ineffective for unapproved indication ": 2.8059422310693307, "Drug level increased ": 5.952001614153716, "Emotional 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61.94275572432765, "Muscle twitching ": 3.130991179562926, "Myoclonus ": 3.048821133390644, "Nervousness ": 2.0987424382245714, "Off label use ": 5.521909550815612, "Overdose ": 5.791951032843361, "Paranoia ": 5.753530859635969, "Partial seizures ": 43.44448147852698, "Petit mal epilepsy ": 26.51918637846004, "Postoperative wound infection ": 15.260027866893164, "Prescribed overdose ": 5.712132665153324, "Product availability issue ": 27.22052828453979, "Product dose omission issue ": 2.3275274622840216, "Product use issue ": 3.065214551849517, "Psychomotor hyperactivity ": 7.345755108065209, "Psychotic disorder ": 13.540948584665262, "Screaming ": 8.222162567088276, "Sedation ": 6.363103093538912, "Seizure ": 17.048341765179778, "Seizure cluster ": 91.35430651773312, "Self-destructive behaviour ": 18.1784230792798, "Sleep disorder ": 3.0024006413297077, "Somnolence ": 3.7794468364786327, "Staphylococcal infection ": 2.374634012613188, "Status epilepticus ": 23.69646905937574, "Sudden unexplained death in epilepsy ": 107.99430888683808, "Suicidal behaviour ": 14.35262861933545, "Suicidal ideation ": 11.144015421193409, "Therapeutic response unexpected ": 2.543404012021999, "Therapy interrupted ": 31.92832533302308, "Thinking abnormal ": 5.448614885860769, "Tonic convulsion ": 25.358977684173944, "Underdose ": 6.090769037701363, "Unevaluable event ": 2.3992235556479544, "Urinary incontinence ": 4.584272025615266, "Wrong technique in product usage process ": 2.4779219780893005} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/203.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/203.json new file mode 100644 index 00000000000..eb96bb8d2e3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/203.json @@ -0,0 +1 @@ +{"Psoriasis ": 38.37623437383036} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/204.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/204.json new file mode 100644 index 00000000000..4e96f91d613 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/204.json @@ -0,0 +1 @@ +{"Anterior chamber cell ": 379.5394755689658, "Anterior chamber flare ": 402.1795221334658, "Anterior chamber inflammation ": 657.2409346490258, "Blindness ": 40.06329091219243, "Blindness transient ": 30.42786773225056, "Detachment of retinal pigment epithelium ": 498.59283968601534, "Endophthalmitis ": 48.52307633803014, "Eye inflammation ": 266.51048458961844, "Eye pain ": 35.02150537037874, "Idiopathic orbital inflammation ": 2660.372760591177, "Intraocular pressure increased ": 62.04947902726558, "Iridocyclitis ": 521.3094560837853, "Keratic precipitates ": 427.41863587669104, "Ocular hyperaemia ": 62.23780902167999, "Product use in unapproved indication ": 5.372244136762104, "Retinal artery occlusion ": 189.09444054438305, "Retinal haemorrhage ": 50.36075305203824, "Retinal occlusive vasculitis ": 1008.7292465087723, "Retinal oedema ": 250.10108620946292, "Retinal pigment epithelial tear ": 366.5736579907837, "Retinal vascular occlusion ": 337.6209236249197, "Retinal vasculitis ": 1058.3681285443824, "Subretinal fluid ": 590.32492324649, "Uveitis ": 142.12030696636904, "Vision blurred ": 18.03831414607306, "Visual acuity reduced ": 129.35655425693488, "Visual impairment ": 17.66306922815562, "Vitreous floaters ": 392.4118346221145, "Vitreous opacities ": 131.73476936043124, "Vitritis ": 1358.4940564151543} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/205.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/205.json new file mode 100644 index 00000000000..468e6f635fc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/205.json @@ -0,0 +1 @@ +{"Atrial fibrillation ": 3.573149110231776, "Blood lactate dehydrogenase increased ": 15.394581403588946, "Contusion ": 9.074132003070314, "Disease progression ": 12.037425945531531, "Gastrointestinal disorder ": 3.1733214865609853, "Haemoglobin decreased ": 4.378308385204996, "Haemorrhage ": 3.0681788348271937, "Haemorrhage subcutaneous ": 42.19485753973184, "Myelodysplastic syndrome ": 19.880619736329056, "Myelosuppression ": 22.305217271544183, "Neutropenia ": 2.9270957471547145, "Neutrophil count decreased ": 3.985331950813275, "Off label use ": 10.071964209180356, "Petechiae ": 8.51423323903242, "Platelet count decreased ": 7.15903087668843, "Prescribed underdose ": 37.800265656865406, "Sepsis ": 2.863726747743638, "Underdose ": 17.415428879345832, "White blood cell count decreased ": 4.685050467870497, "White blood cell count increased ": 10.605860697292952} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/206.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/206.json new file mode 100644 index 00000000000..6be27c95757 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/206.json @@ -0,0 +1 @@ +{"Drug ineffective ": 3.920547473327615, "Epilepsy ": 15.45352692017746, "Off label use ": 2.345528044019679, "Product use issue ": 10.439739296252949, "Respiratory arrest ": 27.030711394120697, "Respiratory depression ": 166.99216145940065, "Seizure ": 8.831169785531339, "Somnolence ": 5.271483754993824, "Status epilepticus ": 66.22376736825215} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/207.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/207.json new file mode 100644 index 00000000000..62d088671dc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/207.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.7281098337410583, "Acquired factor V deficiency ": 117.87009940609104, "Acute graft versus host disease ": 10.937897834987767, "Adenovirus infection ": 14.149599972022587, "Adrenal insufficiency ": 6.692390531629411, "Adrenal suppression ": 19.06480719381573, "Adrenocortical insufficiency acute ": 12.03952252084461, "Adverse drug reaction ": 4.845263320068497, "Alcoholism ": 4.011405458055314, "Alternaria infection ": 116.07700445778656, "Anaemia ": 3.160259205502261, "Anal fissure ": 2.206837254518756, "Angiopathy ": 4.842038965436102, "Arthropod bite ": 2.5485373583746287, "Aspergillus infection ": 6.046332538424179, "Asphyxia ": 3.01882622423519, "Aspiration ": 16.01186398816886, "Asthma ": 15.281180047135278, "Asthmatic crisis ": 5.277310821590377, "BK virus infection ": 10.203487494510412, "Blood calcium increased ": 20.55414381138715, "Blood corticotrophin decreased ": 13.218166422979383, "Blood immunoglobulin E increased ": 58.39619944542872, "Blood lactic acid increased ": 30.42592214966272, "Blood potassium decreased ": 11.539567980308808, "Blood test abnormal ": 13.25760628901097, "Body height decreased ": 2.1800557778595326, "Botulism ": 41.0277891035544, "Bradyarrhythmia ": 2.038666637566187, "Brain herniation ": 2.1818265966283708, "Breath sounds abnormal ": 37.50732027537634, "Bronchial hyperreactivity ": 3.243989488013666, "Bronchial secretion retention ": 11.93272844282886, "Bronchiectasis ": 20.224923658887302, "Bronchitis ": 2.2416119731510604, "Bronchitis bacterial ": 23.353372908367465, "Bronchopulmonary aspergillosis ": 2.845877586195064, "Bronchopulmonary aspergillosis allergic ": 153.45661151596155, "Butterfly rash ": 17.71583457045738, "Cardiac valve disease ": 2.58313229049446, "Central obesity ": 5.2225073673943845, "Chest X-ray abnormal ": 50.14859097325539, "Chest discomfort ": 4.061523130104637, "Cholangitis 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4.360581559156878, "Defaecation urgency ": 5.343920771832232, "Diastolic dysfunction ": 3.90560225138258, "Distractibility ": 7.609857396754732, "Drug hypersensitivity ": 2.7920262670521967, "Drug ineffective ": 2.271144149479289, "Dyspepsia ": 6.910705238992231, "Dysphonia ": 4.344311172158866, "Dyspnoea ": 2.408192003674299, "Dyspnoea exertional ": 2.104296114538529, "Ear pruritus ": 56.23921834332768, "Ectropion ": 52.61492340295462, "Electrocardiogram repolarisation abnormality ": 6.127680521598452, "Embolism venous ": 5.155983529678085, "Emphysema ": 6.315109050383659, "Encephalitis cytomegalovirus ": 29.76743538949785, "Eosinophil count decreased ": 17.98692140487221, "Eosinophil count increased ": 13.470282246746612, "Eosinophilia ": 14.72099839335945, "Eosinophilic bronchitis ": 119.2452919568111, "Eosinophilic granulomatosis with polyangiitis ": 6.107953468187922, "Epstein-Barr viraemia ": 13.848991843215988, "Epstein-Barr virus infection reactivation ": 2.526336161558552, "Erythema ": 2.5688492003266643, "Eye pruritus ": 13.3830850288487, "Eyelid disorder ": 3.831470974777136, "Factor V Leiden mutation ": 44.04725409756571, "Faecal calprotectin increased ": 16.052752804414364, "Female genital tract fistula ": 137.99235345300835, "Forced expiratory volume decreased ": 4.436987903468998, "Forced vital capacity decreased ": 10.345550596987223, "Frequent bowel movements ": 40.49133881938085, "Full blood count abnormal ": 34.05147075057828, "Gastrointestinal inflammation ": 2.21165704363644, "Gastrointestinal ulcer ": 5.328398887963538, "Gastrooesophageal reflux disease ": 8.674658844538305, "Graft versus host disease ": 2.4085773892941043, "Graft versus host disease in gastrointestinal tract ": 12.768010759117397, "Graft versus host disease in liver ": 10.783336630377672, "Graft versus host disease in skin ": 10.127750003212604, "Growth failure ": 37.27284409884139, "Growth retardation ": 8.20655810009678, "Haematochezia ": 13.371931013562667, "Haemoptysis ": 4.195273060025049, "Haemothorax ": 7.928519619769921, "Head deformity ": 15.85349694615426, "Hiatus hernia ": 2.247945742895284, "Human herpesvirus 6 infection ": 5.109612800459093, "Hyperglycaemia ": 3.639015147468984, "Hypogammaglobulinaemia ": 5.500930288797684, "Hyporeflexia ": 2.0737408933281296, "Hypothalamic pituitary adrenal axis suppression ": 16.521413989303944, "Hypovolaemia ": 5.967726970506194, "Hypoxia ": 3.898813490122389, "Hysterectomy ": 3.5367053072578023, "Ill-defined disorder ": 4.195023227944715, "Impaired quality of life ": 3.329062205197135, "Impulsive behaviour ": 2.3161080491186343, "Increased anteroposterior chest diameter ": 106.1072779793699, "Inflammatory bowel disease ": 2.0872131448249704, "Infusion related reaction ": 11.422271630851982, "Inhibitory drug interaction ": 3.437052385875562, "Inspiratory capacity decreased ": 79.49867101686598, "Intentional device misuse ": 2.7832979154744653, "Judgement impaired ": 5.5476410451567295, "Lacrimation 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40.83840925748972, "Oropharyngeal candidiasis ": 4.836272419919271, "Paraesthesia oral ": 16.55266269558192, "Periorbital oedema ": 2.350837245469499, "Pharyngitis streptococcal ": 8.703536075529568, "Platelet count increased ": 20.795334418912905, "Pleural effusion ": 2.1121270573677804, "Pleuritic pain ": 24.903057756599843, "Pneumonia viral ": 5.517517911099858, "Pneumothorax ": 3.869506655743951, "Polyp ": 4.7789135698057725, "Pouchitis ": 22.065366433820596, "Procedural pain ": 61.97940338329205, "Proctitis ": 109.54358055323075, "Productive cough ": 3.0758212251814405, "Pseudo Cushing's syndrome ": 15.599294521545328, "Pulmonary fibrosis ": 6.52703828822927, "Pulmonary function test abnormal ": 115.08364956321054, "Pulmonary mass ": 8.883982298328002, "Radiculopathy ": 92.01664958753116, "Rales ": 9.172967144451034, "Rectal haemorrhage ": 12.827201639878952, "Respiratory symptom ": 4.248392906182893, "Respiratory syncytial virus infection ": 5.057234879258614, "Respiratory tract infection ": 2.0575917018166408, "Reversible airways obstruction ": 37.98496758565716, "Rhinitis allergic ": 28.37765729441456, "Rhinorrhoea ": 4.8169666719002615, "Rhonchi ": 5.614708455050379, "Salpingo-oophorectomy unilateral ": 142.27412353519566, "Secondary adrenocortical insufficiency ": 2.69330128717895, "Secretion discharge ": 2.8572194683161114, "Septic embolus ": 6.395338562829599, "Shock haemorrhagic ": 2.088468596141406, "Sinonasal obstruction ": 9.28894856334398, "Sinus disorder ": 28.029947910834515, "Sinus polyp ": 87.35260589729205, "Sinusitis ": 3.0424069475120654, "Sinusitis fungal ": 43.91451549086277, "Skin lesion ": 6.900106337972303, "Skin striae ": 3.0074910778341315, "Skin test positive ": 6.527595711168761, "Sleep disorder due to a general medical condition ": 25.56865674664422, "Sneezing ": 11.887005014778293, "Sputum culture positive ": 62.3514180663762, "Sputum discoloured ": 10.178126069238433, "Sputum increased ": 3.248305317497433, "Staphylococcal sepsis ": 2.7257276833259088, "Stenotrophomonas infection ": 27.50088727671389, "Suspected suicide ": 2.924468233689423, "Synovial cyst ": 2.099130133272767, "Systemic mycosis ": 36.30205167735398, "Tachypnoea ": 4.012604339831779, "Therapeutic product effect incomplete ": 14.47211388881848, "Therapeutic response shortened ": 2.140309438262549, "Throat clearing ": 17.449373352666097, "Total lung capacity decreased ": 26.15753927417377, "Type 2 diabetes mellitus ": 13.39667373080051, "Upper respiratory fungal infection ": 202.2940538877336, "Upper-airway cough syndrome ": 78.61334216714505, "Use of accessory respiratory muscles ": 15.940698694820531, "Vaginal discharge ": 62.14163161807597, "Vaginal flatulence ": 168.708486554049, "Vasculitis ": 11.923071748185828, "Vena cava filter insertion ": 21.00359492613627, "Vital capacity decreased ": 36.50840408520065, "Vocal cord dysfunction ": 289.63836759828695, "Weight decreased ": 3.5607609082836653, "Wheezing ": 16.163702002149996} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/208.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/208.json new file mode 100644 index 00000000000..dce82cbcec4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/208.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 6.596792511968096, "Acute kidney injury ": 13.430267475823124, "Aggression ": 4.057387510271644, "Amnesia ": 3.889045767515914, "Anxiety disorder ": 42.010011533516206, "Arteriosclerosis coronary artery ": 45.42836115240488, "Atrial fibrillation ": 6.616978752788126, "Blood cholesterol increased ": 2.059448774912401, "Blood creatinine increased ": 7.811397544718428, "Blood potassium increased ": 4.28868497506558, "Blood pressure systolic decreased ": 20.205542814212677, "Blood sodium decreased ": 4.240698395150697, "Blood urea increased ": 3.896770444755978, "Cardiac failure ": 9.040607814696198, "Cardiac failure acute ": 48.36291223594856, "Cardiac failure chronic ": 73.11199206741138, "Cardiac failure congestive ": 6.70058733729879, "Cardiomegaly ": 27.86399905350964, "Completed suicide ": 8.070966578345233, "Coronary artery disease ": 4.215655511604572, "Deafness ": 3.171814098222176, "Dehydration ": 5.133935545247482, "Dermatitis bullous ": 4.744126625006627, "Device malfunction ": 11.105642019747, "Device occlusion ": 41.90979623314222, "Drug dependence ": 2.483385532904476, "Drug withdrawal syndrome ": 5.3303540269639145, "Eating disorder ": 11.562453375194776, "Ejection fraction abnormal ": 37.77797055980027, "Ejection fraction decreased ": 7.202621769364409, "End stage renal disease ": 33.036327395440416, "Faeces discoloured ": 22.72127019674856, "Fluid retention ": 5.860197558167768, "Gait inability ": 5.126562271467251, "Gastrointestinal angiodysplasia ": 693.0067012441299, "Gastrointestinal haemorrhage ": 5.442925584424548, "Generalised oedema ": 6.6065137159538185, "Glomerular filtration rate decreased ": 5.943983092291953, "Gout ": 5.032878512166839, "Helicobacter infection ": 3.866311578004487, "Hospitalisation ": 2.973341954330259, "Hyperkalaemia ": 14.939793212633624, "Hypernatraemia ": 19.02080233809311, "Hypervolaemia ": 9.80238224509852, "Hypokalaemia ": 6.936315030390356, "Hypokinesia ": 5.565785141340589, "Hypomagnesaemia ": 21.3094339833183, "Hyponatraemia ": 4.37472754916349, "Hypotension ": 3.884213705071484, "Hypovolaemia ": 61.97871648184076, "Impaired driving ability ": 29.19821471069218, "Incarcerated hernia ": 1443.7830846389747, "Incorrect dose administered ": 3.149264068794942, "International normalised ratio increased ": 8.493334721022391, "Interstitial lung disease ": 3.851261225899821, "Iron deficiency anaemia ": 9.453690296989397, "Left atrial dilatation ": 462.6818693399988, "Left ventricular dilatation ": 312.61300321709945, "Lethargy ": 3.227079935636893, "Lumbar spinal stenosis ": 111.1047198134594, "Lung hyperinflation ": 424.4136683948769, "Meningitis ": 24.377082120436363, "Mitral valve incompetence ": 42.96962464155932, "Multiple organ dysfunction syndrome ": 3.3194734821854173, "Oedema peripheral ": 4.564941762235514, "Orthostatic hypotension ": 6.8192639134782285, "Overdose ": 6.872812829955204, "Pneumonia ": 2.256293411654253, "Product administration error ": 2.331609469460284, "Psychotic behaviour ": 171.91699021283188, "Psychotic disorder ": 5.855314795899114, "Pulmonary congestion ": 30.546038460782796, "Pulmonary hypertension ": 3.4243357696157606, "Renal impairment ": 5.614002666269199, "Right atrial dilatation ": 556.5390627621568, "Speech disorder ": 4.223316646849057, "Spinal cord abscess ": 1024.6447354191264, "Substance abuse ": 10.415776977316725, "Toxicity to various agents ": 9.163239687410714, "Urine output decreased ": 7.375202630350306, "Ventricular tachycardia ": 7.952151309760993} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/209.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/209.json new file mode 100644 index 00000000000..32887a93315 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/209.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 3.0589886708459497, "Abnormal loss of weight ": 7.009046843402321, "Adverse drug reaction ": 3.165648983819231, "Anaesthetic complication ": 23.08850381165105, "Anal incontinence ": 8.944729713295086, "Anterior spinal artery syndrome ": 886.5884144463513, "Apnoea ": 8.643477787121533, "Arachnoiditis ": 122.6566059986434, "Areflexia ": 21.26904191385626, "Arteriospasm coronary ": 7.463881350510869, "Back pain ": 3.996373404203416, "Benign prostatic hyperplasia ": 7.875061063209982, "Blood pressure decreased ": 3.9405904733346646, "Bradycardia ": 5.34914881292289, "Bradycardia foetal ": 44.37727052545057, "Brain herniation ": 11.88314795847874, "Burning sensation ": 2.494994152406536, "Cardiac arrest ": 4.18691754692918, "Cauda equina syndrome ": 182.106144403854, "Cerebrospinal fluid leakage ": 28.234465703890127, "Complex regional pain syndrome ": 19.028176756671066, "Complication associated with device ": 8.58755153109131, "Constipation ": 2.2075080426635867, "Coordination abnormal ": 2.0789379737135074, "Crepitations ": 41.77879428716924, "Cyanosis ": 4.441604940448888, "Decubitus ulcer ": 8.954260144522411, "Delayed recovery from anaesthesia ": 22.254812764510696, "Delirium ": 5.600010579276528, "Depressed level of consciousness ": 3.588037867947536, "Device dislocation ": 14.97315013106873, "Device failure ": 9.6928166061272, "Device infusion issue ": 34.58683265480888, "Diplopia ": 4.695482313140665, "Discomfort ": 2.2305058301037506, "Drug delivery system malfunction ": 8.137558355126385, "Drug ineffective for unapproved indication ": 2.6802205026410437, "Drug withdrawal syndrome ": 15.95806483657304, "Dysuria ": 2.759067571221247, "Electric shock sensation ": 3.763583928994104, "Exposure during pregnancy ": 6.059204182388702, "Exposure via breast milk ": 11.285164732104995, "Extra dose administered ": 18.115234446117157, "Failed back surgery syndrome ": 511.034546531061, "Foetal death ": 4.481410437167599, "Foetal distress syndrome ": 10.926526119369782, "Foetal exposure during delivery ": 120.48872499744046, "Foetal exposure during pregnancy ": 6.0736251992950665, "Foetal growth restriction ": 15.9667231857266, "Formication ": 3.843513565322045, "Gait inability ": 3.013128516961692, "Generalised tonic-clonic seizure ": 2.4121734829440133, "Haemodynamic instability ": 6.406652284763241, "Heart rate decreased ": 2.0553981491596027, "Horner's syndrome ": 42.95057068080644, "Hospitalisation ": 2.5894959370326998, "Hyperaesthesia ": 7.909444522390193, "Hypoacusis ": 3.160002270525049, "Hypoaesthesia ": 2.6084091254059705, "Hypopnoea ": 9.75713982494687, "Hypotension ": 3.3459717183427045, "Hypothermia ": 2.909448883283917, "Hypoxia ": 3.679595413361564, "Implant site discharge ": 264.4832023807302, "Implant site extravasation ": 66.24372770902625, "Implant site infection ": 49.881796170019705, "Implant site pain ": 158.40017261745592, "Incorrect route of product administration ": 8.87393198142919, "Infusion site mass ": 273.9821206216226, "Intervertebral disc degeneration ": 6.85830655674908, "Ischaemia ": 6.122132805346811, "Kyphosis ": 93.82169501573098, "Labelled drug-drug interaction medication error ": 6.596760473311735, "Lethargy ": 2.432726387351796, "Libido decreased ": 6.772424126502291, "Live birth ": 17.03074081666323, "Local anaesthetic systemic toxicity ": 595.3668374268615, "Loss of consciousness ": 2.303789709968207, "Low birth weight baby ": 10.803296984130249, "Lumbar spinal stenosis ": 44.5916838596932, "Lung disorder ": 3.1614601372670603, "Magnetic resonance imaging abnormal ": 13.306867129314227, "Maternal exposure during breast feeding ": 10.322884496813666, "Maternal exposure during delivery ": 113.3381710601659, "Maternal exposure during pregnancy ": 7.964337031256709, "Medical device discomfort ": 290.63123174664247, "Medical observation ": 292.7905486857145, "Mental status changes ": 6.940268523046822, "Motor dysfunction ": 11.146037610263733, "Movement disorder ": 2.299846032202524, "Multiple sclerosis relapse ": 3.164214167574689, "Muscle rigidity ": 2.2008937839219853, "Muscle spasms ": 3.8031601164019535, "Muscle spasticity ": 27.123164643549632, "Muscle tightness ": 3.4367413629941663, "Muscular weakness ": 2.1269410675909977, "Musculoskeletal chest pain ": 2.1119878155979475, "Myoclonus ": 7.251053418117064, "Neonatal respiratory distress syndrome ": 9.997270337114802, "Neuralgia ": 6.505878910478043, "Neurotoxicity ": 4.582403595753855, "No adverse event ": 13.158126403706996, "Off label use ": 3.2234104539684734, "Ophthalmoplegia ": 89.29806148768498, "Overdose ": 3.840925020580722, "Oxygen saturation 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7.999115264772319, "Sleep apnoea syndrome ": 3.3897731919806624, "Spinal compression fracture ": 17.581425787668437, "Spinal cord compression ": 10.348519821492088, "Spinal cord injury ": 83.65888203080559, "Spinal pain ": 3.986207676866142, "Spinal stenosis ": 12.82591703795982, "Strabismus ": 72.02881007937688, "Symmetrical drug-related intertriginous and flexural exanthema ": 71.44799938243642, "Therapeutic response decreased ": 9.231388280865772, "Therapy non-responder ": 12.400801590646443, "Underdose ": 3.375362282083454, "Unevaluable event ": 8.387640095625544, "Unresponsive to stimuli ": 8.090250159834946, "Urinary incontinence ": 2.994754400430537, "Urinary retention ": 6.604343248881143, "Uterine hypotonus ": 244.2284270762048, "Ventricular arrhythmia ": 12.487877859106089, "Ventricular extrasystoles ": 2.464671298135256, "Ventricular tachycardia ": 3.891210293591878, "Withdrawal syndrome ": 6.501143882900596} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/21.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/21.json new file mode 100644 index 00000000000..4f33a50e869 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/21.json @@ -0,0 +1 @@ +{"Hypoglycaemia ": 7.467925153294567} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/210.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/210.json new file mode 100644 index 00000000000..d8122f380d1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/210.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 2.8355616895806506, "Accident ": 2.315398073472308, "Accidental exposure to product by child ": 17.409660782481858, "Accidental overdose ": 6.53919443231089, "Accidental poisoning ": 54.74420489178731, "Affective disorder ": 3.249911106346879, "Aggression ": 2.165610211180338, "Agitation ": 2.207585711126044, "Agitation neonatal ": 17.284109828083114, "Alcohol abuse ": 25.525510957673585, "Alcohol interaction ": 44.68683468712696, "Alcohol poisoning ": 5.018914508430233, "Amniotic fluid volume decreased ": 24.188356581137707, "Anaemia neonatal ": 19.956743561398472, "Application site burn ": 5.458120222090591, "Application site erythema ": 4.786551077400051, "Application site haemorrhage ": 9.492685819225697, "Application site hypersensitivity ": 15.44300794738935, "Application site inflammation ": 7.765091028739306, "Application site irritation ": 6.1062402543127945, "Application site pruritus ": 8.080385395562752, "Application site rash ": 16.781670821873718, "Application site vesicles ": 4.574628984404338, "Arteriosclerosis coronary artery ": 3.374393736114491, "Asphyxia ": 12.84766290781818, "Aspiration ": 7.280313542139817, "Attention deficit hyperactivity disorder ": 3.0347779519353497, "Back injury ": 14.304654506604487, "Behavioural addiction ": 96.24331586754238, "Blood disorder ": 4.677106849785689, "Bradycardia foetal ": 7.361215404242665, "Bradyphrenia ": 2.197732525837472, "Bradypnoea ": 10.589530073797471, "Brain injury ": 7.700207391473283, "Brain oedema ": 6.383212401596551, "Breakthrough pain ": 19.029211966542384, "Cachexia ": 2.584821650709686, "Cardio-respiratory arrest ": 3.434011060900461, "Central nervous system lesion ": 2.806281438604188, "Central sleep apnoea syndrome ": 14.586589716761187, "Cerebrovascular disorder ": 4.797888877720484, "Choking ": 9.086827072912566, "Cleft palate ": 6.464701926509824, "Cluster headache ": 7.783578870952571, "Cognitive disorder ": 5.050487804365362, "Coma ": 3.020476739536321, "Coma scale abnormal ": 4.122501826544385, "Communication disorder ": 3.1971127140870004, "Compartment syndrome ": 4.805018719094041, "Congenital anomaly ": 4.119362281984643, "Constipation ": 2.566940049199054, "Convulsive threshold lowered ": 28.39325056500068, "Death ": 2.657805406220246, "Defaecation urgency ": 3.314984310491812, "Delirium ": 2.0216086755866853, "Dental caries ": 2.4035610381431987, "Dependence ": 79.08272387997405, "Depressed level of consciousness ": 3.764046151100724, "Depression ": 2.8313104439772623, "Dermal cyst ": 12.284136550451947, "Dermatitis contact ": 2.07891284937889, "Developmental delay ": 14.514236001682152, "Disorientation ": 2.149674896076566, "Drowning ": 11.926260110277816, "Drug abuse ": 21.72410629812369, "Drug abuser ": 19.704887253230016, "Drug delivery system removal ": 68.49806078669826, "Drug dependence ": 86.15548549958771, "Drug detoxification ": 62.7676433318373, "Drug diversion ": 28.714541858225896, "Drug effect less than expected ": 5.539856056226332, "Drug interaction ": 2.7661481870268805, "Drug screen positive ": 67.45730433557031, "Drug tolerance ": 13.567579325375942, "Drug use disorder ": 37.26606121857372, "Drug withdrawal syndrome ": 27.842789035770043, "Drug 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"Impaired quality of life ": 4.118207776924648, "Impetigo ": 6.127622959244162, "Inadequate analgesia ": 22.19814327820291, "Incoherent ": 6.051110483875157, "Infantile spitting up ": 27.81106275828233, "Infertility ": 7.959547325910669, "Inflammatory pain ": 13.26306618132073, "Intentional product misuse ": 9.582081594534106, "Intentional product use issue ": 3.898457835824432, "Intentional self-injury ": 2.683340069917237, "Intentional underdose ": 33.65582974033644, "Intervertebral disc degeneration ": 2.662849265182701, "Jaundice neonatal ": 21.893004660003403, "Lactation insufficiency ": 4.050284222857967, "Learning disability ": 91.58770942141544, "Logorrhoea ": 6.108321229144807, "Loss of employment ": 4.588916946451849, "Low birth weight baby ": 20.25032575669563, "Mastication disorder ": 5.774222572980701, "Maternal exposure during pregnancy ": 6.134404078914449, "Meconium aspiration syndrome ": 55.65212136844276, "Mental disorder ": 3.599401039950524, "Miosis ": 20.801779228987996, "Morning sickness ": 18.22255925453364, "Multiple injuries ": 2.907422192268827, "Mydriasis ": 2.404934533720903, "Myelopathy ": 6.326400490750471, "Neonatal respiratory distress ": 14.094190526716243, "Neonatal respiratory distress syndrome ": 3.092174419768444, "Nephrosclerosis ": 16.353003377355375, "Neurosis ": 10.273899666770747, "Oesophagitis ": 3.557041080146793, "Oral administration complication ": 42.92551807710531, "Overdose ": 14.254464251949674, "Palmoplantar pustulosis ": 16.099570661677454, "Pancreatitis chronic ": 4.602314932703579, "Panic disorder ": 4.889299511850244, "Paranoia ": 2.952757758044624, "Parasomnia ": 31.775020412595183, "Peripheral ischaemia ": 2.1026600225188123, "Persecutory delusion ": 4.591784747475368, "Persistent depressive disorder ": 13.716209978852586, "Personal relationship issue ": 48.42419137200845, "Piloerection ": 6.007709716303477, "Placenta praevia ": 18.21596402642002, "Placental disorder ": 19.89339561215432, "Placental hypertrophy ": 529.6759586755849, "Plantar fasciitis ": 7.228054978638736, "Poisoning ": 6.882243667861207, "Poor feeding infant ": 20.123467965601407, "Post-traumatic stress disorder ": 10.88150043884504, "Potentiating drug interaction ": 2.1222690807636777, "Pre-eclampsia ": 6.531750250919719, "Premature baby ": 9.725551105522197, "Premature delivery ": 14.039920316491598, "Premature labour ": 3.0328779567838144, "Premature rupture of membranes ": 7.456442850774994, "Premature separation of placenta ": 5.754082094937249, "Prescribed overdose ": 2.335282693055624, "Prescription drug used without a prescription ": 8.015065640435287, "Procedural pain ": 2.166426081191697, "Product adhesion issue ": 14.719613437850914, "Product preparation issue ": 52.12205912713963, "Product prescribing issue ": 4.788986931744423, "Product quality issue ": 2.213004071972424, "Psychomotor skills impaired ": 2.2454057652861805, "Psychotic behaviour ": 8.004819329406565, "Psychotic disorder ": 2.1640287058647862, "Pulmonary congestion ": 4.379786577794716, "Pulmonary oedema ": 3.3249581535122426, "Pulse absent ": 2.7437927120993386, "Quadriparesis ": 9.843175232473977, "Respiratory acidosis ": 3.0958540336687204, "Respiratory arrest ": 4.297963865726016, "Respiratory depression ": 14.354534020794986, "Respiratory disorder neonatal ": 14.351174185680282, "Respiratory rate decreased ": 5.974765783079768, "Rib fracture ": 2.6467355133248778, "Road traffic accident ": 4.476398343965341, "Sarcopenia ": 30.476718574151896, "Schizophrenia ": 3.2067626358179955, "Sciatica ": 2.171464614485522, "Seborrhoeic dermatitis ": 5.307505567934524, "Secondary hypogonadism ": 45.783319740548585, "Sedation ": 5.074305626637121, "Selective eating disorder ": 5.307505567934524, "Self-destructive behaviour ": 5.285419918779858, "Serotonin syndrome ": 3.970031472505516, "Skin abrasion ": 2.6337676566742574, "Skin irritation ": 4.579212984235571, "Small for dates baby ": 5.180718896981786, "Social anxiety disorder ": 15.279515369689966, "Somnambulism ": 35.9118997521194, "Somnolence ": 2.2048592885403626, "Spinal osteoarthritis ": 3.0141828150622616, "Spinal stenosis ": 3.0566813428185005, "Stillbirth ": 4.073437245769126, "Stress cardiomyopathy ": 2.489382802336752, "Substance abuse ": 49.51614315149234, "Substance dependence ": 5.169138856838602, "Substance use ": 16.87081871335275, "Substance use disorder ": 159.01471099110535, "Substance-induced psychotic disorder ": 14.284913224900988, "Suicidal ideation ": 2.9902942532345143, "Suicide attempt ": 2.729006637667482, "Suspected suicide ": 3.902483120308784, "Therapeutic response delayed ": 10.908461571499792, "Therapy interrupted ": 2.5815328629074745, "Thermal burn ": 29.20837035941515, "Tooth disorder ": 2.271922816643417, "Toxicity to various agents ": 9.790995253756844, "Tremor neonatal ": 56.35963320296602, "Type IIa hyperlipidaemia ": 53.46692491119072, "Umbilical cord around neck ": 15.315674338477075, "Unresponsive to stimuli ": 3.654478409210671, "Vitamin B12 deficiency ": 6.258006334091199, "Withdrawal syndrome ": 12.966031460338863, "Wrong technique in product usage process ": 2.941218171317923, "Yawning ": 9.91141519496481} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/211.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/211.json new file mode 100644 index 00000000000..5883858326a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/211.json @@ -0,0 +1 @@ +{"Acute graft versus host disease ": 81.29891484665166, "Acute graft versus host disease in skin ": 118.4034805952871, "Acute lymphocytic leukaemia ": 57.448449464922845, "Acute lymphocytic leukaemia recurrent ": 56.284012797622, "Acute myeloid leukaemia ": 19.24598785197774, "Acute respiratory distress syndrome ": 14.320446438032931, "Adenovirus infection ": 48.6658719199235, "Bacterial sepsis ": 83.33242876119397, "Blood culture positive ": 103.77352728849492, "Bone marrow failure ": 38.27667475952431, "Bone marrow leukaemic cell infiltration ": 2456.0126545508742, "Bronchopulmonary aspergillosis ": 26.42179859007554, "Cardiac failure ": 3.039116890426894, "Cardiogenic shock ": 15.663790544067131, "Chronic graft versus host disease ": 92.25667860801164, "Cystitis haemorrhagic ": 97.63855129890494, "Cytomegalovirus infection ": 194.71393876786763, "Cytomegalovirus infection reactivation ": 27.77254114733388, "Dermatitis bullous ": 12.529835505686144, "Disease recurrence ": 14.74881943694129, "Ejection fraction decreased ": 16.800757351779417, "Encephalopathy ": 7.479959172991069, "Engraftment syndrome ": 413.5642157944732, "Epstein-Barr virus infection ": 98.65928912553773, "Epstein-Barr virus infection reactivation ": 168.89007609724024, "Febrile bone marrow aplasia ": 74.02413595356012, "Febrile neutropenia ": 11.183740004502177, "Gamma-glutamyltransferase increased ": 3.423438738546759, "Graft versus host disease ": 23.23780984134875, "Haematuria ": 4.311988840851732, "Hepatic cytolysis ": 18.580576274601707, "Hepatitis acute ": 14.783695190770024, "Hepatosplenomegaly ": 56.23841639202787, "Infection ": 2.909542338639981, "Leukaemia recurrent ": 121.42520941204472, "Lung disorder ": 5.911660749875731, "Mucosal inflammation ": 48.793652386192434, "Multiple organ dysfunction syndrome ": 7.743620550804389, "Myocarditis ": 8.446375965893624, "Neurotoxicity ": 12.943401651148482, "Pericarditis ": 3.152704432560703, "Platelet count increased ": 17.440617916739587, "Post transplant lymphoproliferative disorder ": 71.99214415824973, "Pseudomonal sepsis ": 174.78341325570173, "Rash maculo-papular ": 2.386765216578421, "Respiratory failure ": 2.8659695464173565, "Sepsis ": 8.610528958386942, "Septic shock ": 21.38006151640097, "Serratia sepsis ": 2701.909723011382, "Staphylococcal infection ": 8.324231707801951, "Stomatitis ": 14.75385260905805, "Thrombotic microangiopathy ": 42.7143209847935, "Venoocclusive disease ": 754.830182378999, "Venoocclusive liver disease ": 271.66230054057127} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/212.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/212.json new file mode 100644 index 00000000000..54adf0bc3db --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/212.json @@ -0,0 +1 @@ +{"Acidosis hyperchloraemic ": 14.107815542605156, "Acute graft versus host disease ": 193.1440571328875, "Acute graft versus host disease in intestine ": 200.55528389491263, "Acute graft versus host disease in liver ": 182.15539990892736, "Acute graft versus host disease in skin ": 311.7448682611912, "Acute hepatic failure ": 2.780124815509895, "Acute lymphocytic leukaemia ": 10.02491392024542, "Acute myeloid leukaemia ": 10.57452617726285, "Acute myeloid leukaemia recurrent ": 55.16017813971893, "Acute respiratory distress syndrome ": 12.648409319138288, "Adenovirus infection ": 95.57277397423591, "Anal abscess ": 4.576783656522131, "Aplasia pure red cell ": 3.1618252550748163, "Aplastic anaemia ": 25.37713273505147, "Ascites ": 3.594930684798791, "Aspergillus infection ": 23.474763388473686, "Atrial flutter ": 7.240047845761822, "Atrial thrombosis ": 7.890785400445456, "Atrophy ": 9.992748364049136, "Autoimmune haemolytic anaemia ": 14.26162216381147, "BK virus infection ": 147.88251810344386, "Bacteraemia ": 25.7529876452356, "Bacterial infection ": 5.941789298979464, "Bacterial sepsis ": 25.124643237476256, "Blast crisis in myelogenous leukaemia ": 20.97366734128727, "Blood bilirubin increased ": 3.486862881073948, "Blood culture positive ": 27.83480096752594, "Blood follicle stimulating hormone increased ": 190.06893961592425, "Blood lactate dehydrogenase increased ": 3.005814240597992, "Blood luteinising hormone increased ": 295.7777902260594, "Bone marrow failure ": 18.62500982922477, "Bone marrow transplant rejection ": 39.907332911292194, "Bronchiectasis ": 11.1842811433471, "Bronchopulmonary aspergillosis ": 27.417968481722333, "Budd-Chiari syndrome ": 44.935351663465546, "Candida infection ": 6.315696963843496, "Capillary leak syndrome ": 6.670903162944272, "Cardiac failure acute ": 2.0816267485492226, "Cardiac tamponade ": 5.509416723798056, "Cardiotoxicity ": 5.151881238545597, "Central hypothyroidism ": 27.285836494781847, "Central nervous system lesion ": 3.715261734248279, "Cerebral toxoplasmosis ": 70.89546080389519, "Cervical dysplasia ": 6.993450106179345, "Chloroma ": 94.02116822976492, "Chronic graft versus host disease ": 170.66887498562906, "Chronic graft versus host disease in intestine ": 138.414886265655, "Chronic graft versus host disease in liver ": 107.35096369770751, "Chronic graft versus host disease in skin ": 138.67113462874983, "Chronic myeloid leukaemia ": 4.06699021696152, "Clostridium difficile colitis ": 8.38059916654329, "Clostridium difficile infection ": 7.298510760995515, "Congenital aplasia ": 13.573785602251816, "Coombs positive haemolytic anaemia ": 22.04517632426809, "Cystitis haemorrhagic ": 217.53504642696905, "Cystitis viral ": 115.02302626300973, "Cytokine release syndrome ": 2.2463588051073278, "Cytomegalovirus chorioretinitis ": 61.42438269606701, "Cytomegalovirus colitis ": 8.628847777560736, "Cytomegalovirus infection ": 63.95201148293373, "Cytomegalovirus infection reactivation ": 159.62287621601405, "Cytomegalovirus test positive ": 59.35296027131064, "Cytomegalovirus urinary tract infection ": 1227.9181626583058, "Cytomegalovirus viraemia ": 146.91842158669846, "Cytopenia ": 5.670162834400365, "Delayed puberty ": 129.02125984041857, "Device related infection ": 8.281061265787423, "Diarrhoea haemorrhagic ": 2.072825104284488, "Diffuse alveolar damage ": 32.70588557987999, "Diffuse large B-cell lymphoma ": 6.482789056245867, "Disease recurrence ": 2.807656527548968, "Disseminated intravascular 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2.719897178621857, "Hepatic failure ": 3.617915090601779, "Hepatic necrosis ": 9.069035468308886, "Hepatitis B reactivation ": 5.724345535841566, "Hepatomegaly ": 6.599491125356257, "Hepatorenal syndrome ": 8.959935614720834, "Hepatotoxicity ": 2.431575437933876, "Herpes simplex ": 15.249599885558348, "Herpes virus infection ": 2.6719051513592813, "Hodgkin's disease recurrent ": 39.907332911292194, "Human herpesvirus 6 encephalitis ": 118.49804674405908, "Human herpesvirus 6 infection ": 62.01914261454116, "Human polyomavirus infection ": 66.82798057863587, "Hyperammonaemia ": 2.090967040869951, "Hyperbilirubinaemia ": 3.87806983093957, "Hyperlipidaemia ": 2.853827667827028, "Hypouricaemia ": 40.73581760421237, "Idiopathic pneumonia syndrome ": 163.27742089422068, "Infection ": 3.872066821518728, "Infection reactivation ": 55.12921392895281, "Intervertebral disc protrusion ": 3.254940609237684, "JC virus infection ": 40.178881316155525, "Kaposi's sarcoma ": 14.889126175579989, "Keratitis ": 5.713810577548849, "Klebsiella infection ": 36.0755318906041, "Klebsiella sepsis ": 17.184254697535707, "Laryngitis fungal ": 102.8057420411659, "Left ventricular failure ": 5.956514453682168, "Leukaemia ": 3.096675511503505, "Leukaemia recurrent ": 70.90840328640249, "Leukoencephalopathy ": 6.555732155237148, "Lower respiratory tract infection fungal ": 48.61019454980439, "Lung disorder ": 2.368149783602854, "Lung opacity ": 4.047817045541906, "Lymphopenia ": 2.9730582623370165, "Lymphoproliferative disorder ": 17.796190320270146, "Marrow hyperplasia ": 17.4808144502965, "Meningitis tuberculous ": 22.12015713521552, "Metapneumovirus infection ": 30.61399722634533, "Metastasis ": 5.177259549220746, "Microangiopathy ": 15.405417284640798, "Mouth ulceration ": 3.9299150183359046, "Mucormycosis ": 44.88734426588955, "Mucosal disorder ": 4.335723610741874, "Mucosal inflammation ": 47.55871649349039, "Multiple organ dysfunction syndrome ": 10.286826091907466, "Myelitis 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"Pneumonia bacterial ": 4.195578829682562, "Pneumonia cytomegaloviral ": 48.776310994085286, "Pneumonia fungal ": 23.135992557986835, "Pneumonia klebsiella ": 21.14592111819901, "Pneumonitis ": 4.553334006101009, "Pneumothorax ": 2.3874695951704363, "Polyomavirus viraemia ": 241.51640210653483, "Post transplant lymphoproliferative disorder ": 51.63142090930607, "Posterior reversible encephalopathy syndrome ": 19.12680278572686, "Premature menopause ": 114.60410294816032, "Primary hypogonadism ": 400.9560442398337, "Product administered to patient of inappropriate age ": 11.65685254376015, "Product use in unapproved indication ": 9.461775269568596, "Progressive multifocal leukoencephalopathy ": 16.87596785205346, "Pseudomonal sepsis ": 13.548186059616684, "Pseudomonas infection ": 6.907619324354034, "Pulmonary alveolar haemorrhage ": 10.708045178031195, "Pulmonary arterial hypertension ": 4.648918764940071, "Pulmonary haemorrhage ": 10.549305345227154, "Pulmonary hypertension ": 6.157160189285119, "Pulmonary toxicity ": 2.6548958598537378, "Pulmonary veno-occlusive disease ": 113.54709767033808, "Recurrent cancer ": 12.887386691288976, "Renal tubular injury ": 49.40772620954456, "Respiratory disorder ": 2.18439540244822, "Respiratory distress ": 2.2399693591287235, "Respiratory failure ": 6.7779388582490245, "Respiratory syncytial virus infection ": 3.96868516111113, "Respiratory tract infection fungal ": 41.77716462776085, "Retinitis viral ": 479.3895253684181, "Retinopathy haemorrhagic ": 209.98767731643892, "Rhinovirus infection ": 17.005345014307576, "Right ventricular failure ": 4.986543555337947, "Second primary malignancy ": 5.633053036629699, "Sepsis ": 7.653170908254111, "Septic shock ": 8.000990570657361, "Shock haemorrhagic ": 3.6374516851319503, "Skin hyperpigmentation ": 2.7998063634887425, "Skin toxicity ": 14.14410952124942, "Spinal stenosis ": 6.296922416291861, "Splenomegaly ": 2.0479511522766205, "Staphylococcal bacteraemia ": 13.39856314880448, "Staphylococcal infection ": 6.017526315367524, "Staphylococcal sepsis ": 13.735725712470389, "Stenotrophomonas infection ": 11.479898729220585, "Stomatitis ": 7.1454754010075545, "Streptococcal bacteraemia ": 97.51845121984452, "Systemic candida ": 11.372327522008648, "Systemic inflammatory response syndrome ": 4.754218232193952, "T-lymphocyte count decreased ": 34.37570549720736, "Testicular atrophy ": 56.37602115457624, "Therapy non-responder ": 2.042154624941661, "Thrombocytopenia ": 3.671840911183093, "Thrombotic microangiopathy ": 59.23649296479554, "Thrombotic thrombocytopenic purpura ": 9.798962658381337, "Toxic encephalopathy ": 3.9563340857626166, "Toxoplasmosis ": 62.79826536846847, "Transplant failure ": 135.55401003759306, "Transplant rejection ": 19.32369913481561, "Traumatic lung injury ": 12.417675481283103, "Tubulointerstitial nephritis ": 3.4627656282054597, "Urinary tract obstruction ": 15.6178632561089, "Vanishing bile duct syndrome ": 45.24553595218547, "Varicella zoster virus infection ": 20.3689079644511, "Venoocclusive disease ": 300.2737355872748, "Venoocclusive liver disease ": 300.06852248616127, "Viral haemorrhagic cystitis ": 247.341756697426, "Viral infection ": 5.560984792106985} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/213.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/213.json new file mode 100644 index 00000000000..ce9c21ccf1d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/213.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 11.042530920582866, "Alcohol poisoning ": 65.59706160161677, "Drug dependence ": 4.887444626431577, "Drug titration error ": 1356.4727640371566, "Drug withdrawal syndrome ": 9.062927083250036, "Drug withdrawal syndrome neonatal ": 71.03492023019396, "Exposure via breast milk ": 41.70322730908055, "Foetal exposure during pregnancy ": 6.855405136629372, "Gestational diabetes ": 63.6846969407586, "Hyperhidrosis ": 2.217549279028442, "Injection site abscess ": 90.3706894690186, "Injection site erythema ": 11.58112562317231, "Injection site induration ": 14.16411226087345, "Injection site inflammation ": 2.3447024669156016, "Injection site mass ": 132.48201321544602, "Injection site nodule ": 101.10611988042058, "Injection site pain ": 5.816680215162662, "Injection site pruritus ": 16.98901595649729, "Injection site rash ": 17.38515844174335, "Injection site reaction ": 3.042190760083189, "Injection site swelling ": 8.387197302836425, "Injection site warmth ": 2.733437071209195, "Jaundice neonatal ": 200.11772087021816, "Maternal exposure during pregnancy ": 13.16100771631348, "Oedema peripheral ": 2.725482452977497, "Overdose ": 2.4082585554776474, "Poor feeding infant ": 160.53676347776343, "Premature baby ": 5.547184045710002, "Respiratory depression ": 12.637224958243204, "Toxicity to various agents ": 5.651454062519102, "Urinary retention ": 6.081981140639653, "Withdrawal syndrome ": 60.19141039914823, "Yawning ": 74.95806986209539} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/214.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/214.json new file mode 100644 index 00000000000..52e6423e4db --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/214.json @@ -0,0 +1 @@ +{"Adenocarcinoma pancreas ": 41.74260263019695, "Amylase increased ": 3.8195740959409608, "Atelectasis ": 4.164024426438449, "Basal cell carcinoma ": 2.477330726259868, "Benign prostatic hyperplasia ": 4.465037362524358, "Blood cholesterol abnormal ": 5.854940637230367, "Blood glucose abnormal ": 7.297975957081946, "Blood glucose decreased ": 8.964189560419271, "Blood glucose fluctuation ": 8.447441990114704, "Blood glucose increased ": 8.725857667282526, "Blood pressure abnormal ": 2.190424629530429, "Blood triglycerides increased ": 3.946205933609871, "Body height decreased ": 15.00285044536366, "Breast cancer female ": 6.364684333324517, "Carotid artery occlusion ": 4.771356287771768, "Carpal tunnel syndrome ": 3.856835323588883, "Cataract ": 4.15670668816539, "Cellulitis ": 2.53328242977071, "Cholecystectomy ": 8.94217434109356, "Cholelithiasis ": 4.954964630147122, "Circumstance or information capable of leading to device use error ": 89.40968381714825, "Circumstance or information capable of leading to medication error ": 28.801118774679463, "Colon cancer ": 3.4066561469067125, "Coronary artery occlusion ": 8.89586596694438, "Cyst ": 2.459582049628099, "Decreased appetite ": 2.4648638895146715, "Dehydration ": 2.6537587880092874, "Device defective ": 27.50218025760453, "Device delivery system issue ": 34.04987237920876, "Device difficult to use ": 9.675071457351104, "Device failure ": 3.854957170903627, "Device issue ": 33.62678827150396, "Device leakage ": 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22.28819826008692, "Injection site injury ": 33.231796607408334, "Injection site mass ": 80.01332610649331, "Injection site necrosis ": 5.6828267251085975, "Injection site nodule ": 388.8071772502229, "Injection site pain ": 3.123125430483474, "Injection site pruritus ": 9.29306652733537, "Injection site rash ": 5.837601091861755, "Injection site scab ": 56.7557451221051, "Injection site scar ": 40.95262671786841, "Injection site urticaria ": 15.17340043887058, "Injection site vesicles ": 7.670003761909322, "Injury associated with device ": 7.308267553787056, "Insulin-requiring type 2 diabetes mellitus ": 31.5742236418412, "Insurance issue ": 13.116615424905246, "Intentional device misuse ": 99.47828675714672, "Intentional product misuse ": 6.5403382336719655, "Jaundice cholestatic ": 4.363531748487131, "Limb injury ": 2.2469765588098336, "Lip swelling ": 2.115883565434862, "Lipase increased ": 7.919849003659774, "Localised infection ": 7.819829272515478, "Lymphoedema ": 2.0431123165066314, "Malignant melanoma ": 2.6930509632110757, "Mass ": 3.440559528329461, "Memory impairment ": 2.089332292815164, "Metastases to liver ": 4.116329768710287, "Metastases to peritoneum ": 5.416495187854698, "Metastatic neoplasm ": 5.667639540984428, "Muscle disorder ": 7.991330998583714, "Myocardial infarction ": 2.061323222620743, "Near death experience ": 4.248315792012976, "Neck injury ": 14.330651041379928, "Needle issue ": 37.59307232454269, "Nephrolithiasis ": 2.8362291717622337, "Nodule ": 4.519201336352137, "Obesity ": 3.0532159669409067, "Obstructive sleep apnoea syndrome ": 3.998902086463563, "Pancreatic carcinoma ": 16.353532438122055, "Pancreatic carcinoma metastatic ": 29.75688608270224, "Pancreatic cyst ": 10.7856489927379, "Pancreatic disorder ": 7.058984747317663, "Pancreatitis ": 13.29379487448506, "Pancreatitis acute ": 7.457948544560627, "Parkinson's disease ": 2.945994895410787, "Product dispensing error ": 2.939158479693294, "Product dose omission issue ": 7.021648117853322, "Product packaging quantity issue ": 38.02297957018376, "Product preparation issue ": 2.3377121911350414, "Product quality issue ": 16.076680641113548, "Product solubility abnormal ": 19.281671564516795, "Prostate cancer ": 3.679508494307686, "Prostatomegaly ": 6.004422029193521, "Radiotherapy ": 10.687305041830118, "Renal cyst ": 2.2557089531428205, "Retinal detachment ": 2.7174814349954635, "Road traffic accident ": 2.08191867192392, "Skin mass ": 10.135354899374036, "Stress ": 2.550168436074544, "Therapy cessation ": 6.06882401555604, "Thyroid cancer ": 5.823697970544982, "Thyroid mass ": 14.754103062646951, "Transient ischaemic attack ": 2.056739381157648, "Type 2 diabetes mellitus ": 7.495532290550348, "Underdose ": 2.3256064290790737, "Uterine cancer ": 3.748669625840797, "Weight decreased ": 7.575162487703294, "Weight fluctuation ": 8.161692824268334, "Weight increased ": 2.039368076335262, "Wrong technique in device usage process ": 52.990063599492, "Wrong technique in product usage process ": 4.06103647505537} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/215.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/215.json new file mode 100644 index 00000000000..86f0bc85b5d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/215.json @@ -0,0 +1 @@ +{"Abdominal hernia ": 10.884716350995316, "Abdominal tenderness ": 2.6399743846188577, "Abnormal loss of weight ": 7.326786308921675, "Acquired diaphragmatic eventration ": 39.49797397591037, "Acute kidney injury ": 2.66414112265185, "Adenocarcinoma pancreas ": 220.0514409421921, "Adrenal adenoma ": 48.555329636039154, "Adrenal mass ": 27.44076390190085, "Amylase increased ": 5.246513096176721, "Anaemia of chronic disease ": 23.2573218001352, "Aortic arteriosclerosis ": 14.444661576728985, "Appendicectomy ": 15.156697003631898, "Arterial occlusive disease ": 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loss anaemia ": 4.24326773698921, "Blood triglycerides increased ": 7.668896028237928, "Body height decreased ": 5.856380915118072, "Breast conserving surgery ": 10.777439124763731, "Cancer pain ": 3.9114837722627223, "Cardiac murmur ": 3.011778049493324, "Cardiac pacemaker insertion ": 2.6532263708259225, "Carpal tunnel syndrome ": 2.909981130563528, "Cataract ": 3.0331457871395338, "Cataract operation ": 13.073975548849733, "Catheterisation cardiac ": 5.082865079975116, "Cholangiocarcinoma ": 10.526791795499086, "Cholangitis ": 8.09432931521846, "Cholangitis acute ": 18.52911236636841, "Cholecystectomy ": 26.493886455999068, "Cholecystitis ": 7.171918699960036, "Cholecystitis acute ": 8.964901186281852, "Cholecystitis chronic ": 39.24058079973306, "Cholelithiasis ": 18.790855081611348, "Chronic gastritis ": 3.4449357244123275, "Circumstance or information capable of leading to medication error ": 2.481284853379462, "Colitis ischaemic ": 3.4904774463724806, "Colon cancer ": 2.788786470719369, "Colorectal adenoma ": 20.822940479109377, "Complication associated with device ": 3.262646937582889, "Coronary arterial stent insertion ": 12.428340299175249, "Coronary artery bypass ": 5.515673891298287, "Coronary artery disease ": 4.830367515769646, "Coronary artery occlusion ": 2.820992169543418, "Coronary artery stenosis ": 2.541753336513328, "Cyst ": 2.294999103102726, "Decreased appetite ": 2.1198243372872647, "Dehydration ": 3.924098721849264, "Device delivery system issue ": 4.649818286858428, "Device issue ": 3.7718318427895663, "Device leakage ": 6.8978785488455605, "Device malfunction ": 3.97291368325473, "Device use issue ": 3.625350070257985, "Diabetes mellitus inadequate control ": 7.847008794553672, "Diabetic ketoacidosis ": 2.107470548018147, "Diabetic nephropathy ": 10.601798627392656, "Diabetic neuropathy ": 18.989934859311205, "Diabetic retinopathy ": 4.392459873595424, "Diverticulitis ": 4.721437047471437, "Diverticulum ": 8.88894968086237, "Diverticulum intestinal ": 9.519097822420362, "Ductal adenocarcinoma of pancreas ": 82.77309843270505, "Duodenal obstruction ": 41.2908445716403, "Duodenal ulcer ": 3.5073088472060245, "Duodenitis ": 13.78139755827861, "Dyslipidaemia ": 3.5159773124968674, "Dyspepsia ": 2.095497932222972, "Early satiety ": 28.94310438815108, "Eructation ": 4.1031336814865575, "Essential hypertension ": 7.666152884303497, "Exostosis ": 2.0948461308653394, "Failure to thrive ": 4.205563974512833, "Feeling jittery ": 4.095411907402606, "Flank pain ": 2.623543066663012, "Follicular thyroid cancer ": 62.100327209614754, "Gallbladder disorder ": 8.018638933051415, "Gallbladder operation ": 5.221135924767798, "Gastric bypass ": 10.311398945272376, "Gastritis ": 5.467658728013177, "Gastroenteritis ": 3.131032720511448, "Gastroenterostomy ": 97.0623562272919, "Gastrooesophageal reflux disease ": 3.873405957214678, "Glycosylated haemoglobin increased ": 11.171252323411396, "Goitre ": 31.809221402745628, "Gout ": 3.015934234049155, "Hepatic cancer ": 2.947015358870562, "Hepatic cancer metastatic ": 28.547028122901526, "Hepatic cirrhosis ": 3.053137954394757, "Hepatic cyst ": 10.055521341695576, "Hepatic lesion ": 6.904393071905728, "Hepatic mass ": 12.024211637252533, "Hepatic steatosis ": 9.350644960948664, "Hernia repair ": 13.749405786923012, "Hiatus hernia ": 4.68797654007014, "Hunger ": 3.876722424592612, "Hydronephrosis ": 2.5738949700547136, "Hypercholesterolaemia ": 9.085032833508189, "Hyperglycaemia ": 2.918997002838631, "Hyperlipidaemia ": 13.93052111593498, "Hypertriglyceridaemia ": 3.46721700548565, "Hypoglycaemia ": 2.4454183994974703, "Hypoglycaemic unconsciousness ": 3.6482375602523343, "Hypomagnesaemia ": 2.773870839339415, "Hypothyroidism ": 2.9668120296031213, "Hypovolaemia ": 2.153618768855323, "Hysterectomy ": 12.624110253195848, "Ileus ": 2.82373570948684, "Impaired gastric emptying ": 10.259747547109882, "Incorrect dose administered by device ": 3.9729771557288247, "Inguinal hernia ": 3.1636220843315157, "Injection site bruising ": 3.464263353827132, "Injection site extravasation ": 5.433490753360112, "Injection site haemorrhage ": 5.426434187367427, "Insulin resistance ": 4.568946468936606, "Insulin-requiring type 2 diabetes mellitus ": 102.04665456066388, "Intentional device misuse ": 19.66679124523517, "Intervertebral disc degeneration ": 4.3980560705519895, "Intestinal metastasis ": 19.22185324912504, "Intraductal papillary mucinous neoplasm ": 64.79127645870685, "Iron deficiency anaemia ": 4.925895063485154, "Jaundice cholestatic ": 30.374807251659902, "Laparoscopy ": 121.00273941163998, "Laparotomy ": 31.393207565366254, "Large intestine polyp ": 4.831315081878024, "Leukocytosis ": 2.449650134349874, "Limb injury ": 2.211694638895096, "Lipase increased ": 10.136331236647957, "Liver abscess ": 4.106544327383777, "Malignant ascites ": 77.72463427589034, "Malnutrition ": 7.607901465940682, "Medullary thyroid cancer ": 55.72367560562081, "Metastases to abdominal cavity ": 17.248697992406434, "Metastases to adrenals ": 10.333741608504498, "Metastases to liver ": 30.45572009179837, "Metastases to lung ": 12.670800529081014, "Metastases to lymph nodes ": 25.765809699884667, "Metastases to peritoneum ": 36.804315125463, "Metastases to spleen ": 30.26868209216557, "Metastatic neoplasm ": 7.273380179448467, "Nephrolithiasis ": 4.563248896987959, "Neuroendocrine tumour ": 8.674153217862413, "Non-alcoholic steatohepatitis ": 9.072284187549329, "Normocytic anaemia ": 3.55184204835388, "Obstruction gastric ": 31.22489130869108, "Obstructive pancreatitis ": 34.13640529153494, "Obstructive sleep apnoea syndrome ": 7.292328161370191, "Oedematous pancreatitis ": 11.54977510854166, "Osteoarthritis ": 2.7011947326082164, "Overweight ": 4.594623835629918, "Pancreatectomy ": 134.9346561572111, "Pancreatic carcinoma ": 145.43536473368553, "Pancreatic carcinoma metastatic ": 218.8257052472164, "Pancreatic carcinoma recurrent ": 108.53505549207446, "Pancreatic carcinoma stage IV ": 87.85846710344173, "Pancreatic cyst ": 37.945158051264414, "Pancreatic disorder ": 6.109646030140581, "Pancreatic duct dilatation ": 81.44228212874353, "Pancreatic duct obstruction ": 67.92853781353745, "Pancreatic enzymes increased ": 5.567986881249192, "Pancreatic failure ": 18.18703435115625, "Pancreatic mass ": 67.00228546997259, "Pancreatic neoplasm ": 32.80685181748222, "Pancreatic neuroendocrine tumour ": 44.55632003066437, "Pancreatic neuroendocrine tumour metastatic ": 96.14014129169658, "Pancreatic pseudocyst ": 26.2798904508502, "Pancreatic stent placement ": 93.48750618786488, "Pancreaticoduodenectomy ": 107.68938426721324, "Pancreatitis ": 31.44804119598424, "Pancreatitis acute ": 24.718934351883235, "Pancreatitis chronic ": 92.87566972861912, "Pancreatitis haemorrhagic ": 20.424036291162206, "Pancreatitis necrotising ": 21.51144230105459, "Pancreatitis relapsing ": 46.569648047079085, "Panic disorder ": 2.32823854958584, "Papillary thyroid cancer ": 76.32777601954106, "Peripheral venous disease ": 2.447988307281232, "Pneumobilia ": 96.8829292325847, "Polyp ": 2.813994962645586, "Portal hypertension ": 3.736345191910292, "Post procedural hypothyroidism ": 241.0856269030708, "Post procedural infection ": 3.6446276271560185, "Postoperative wound infection ": 3.716992369920854, "Product dose omission issue ": 2.600484910108261, "Product quality issue ": 4.809079677645833, "Prostatic calcification ": 72.36487152243265, "Prostatomegaly ": 4.505551160562772, "Pulmonary mass ": 7.945015212628883, "Radiotherapy ": 13.138150580608652, "Renal cyst ": 11.820188590118477, "Renal disorder ": 2.2197478446072907, "Renal failure ": 2.104690136528696, "Renal tubular necrosis ": 2.024606950689963, "Retinopathy ": 3.510448414763377, "Road traffic accident ": 2.113078741334117, "Rotator cuff repair ": 13.606263001410984, "Rotator cuff syndrome ": 2.704555257417912, "Sinus node dysfunction ": 3.329253637347524, "Sleep apnoea syndrome ": 4.132514895121318, "Small intestinal obstruction ": 2.865651068245033, "Spinal operation ": 4.561501882742915, "Spinal osteoarthritis ": 4.104653180950861, "Splenectomy ": 35.15420405709042, "Stent placement ": 6.044070256644217, "Stomach mass ": 30.33225054146053, "Stress ": 2.175542803836019, "Thyroid cancer ": 42.425484437229386, "Thyroid cancer metastatic ": 40.7296587505901, "Thyroid mass ": 19.895979414458694, "Thyroid neoplasm ": 9.93728604066932, "Thyroidectomy ": 9.939138463734446, "Umbilical hernia ": 8.505569508829964, "Urinary tract disorder ": 4.214876729977447, "Weight decreased ": 9.762070956572993, "Weight fluctuation ": 10.676920687446904, "Wrong technique in device usage process ": 3.4736591190419754} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/216.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/216.json new file mode 100644 index 00000000000..126c6f75606 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/216.json @@ -0,0 +1 @@ +{"Angioedema ": 17.53470246021304, "Drug hypersensitivity ": 11.280292227795975, "Drug ineffective ": 4.981604970328679, "Hereditary angioedema ": 355.3965786839803, "Off label use ": 10.556452015133576, "Prescribed overdose ": 54.40658618686044, "Stress ": 20.750398350407863, "Therapeutic product effect incomplete ": 6.700239562680315} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/217.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/217.json new file mode 100644 index 00000000000..25542acdc4d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/217.json @@ -0,0 +1 @@ +{"Anaemia ": 4.103917077824526, "Bone pain ": 2.7723359135096217, "Disease progression ": 5.120008051617773, "Febrile neutropenia ": 19.070954794234314, "Flushing ": 2.6711695197296224, "Haematuria ": 12.222986977602348, "Haemoglobin decreased ": 3.2075849542578747, "Hepatotoxicity ": 5.925754882445448, "Hormone-refractory prostate cancer ": 845.3219083029279, "Hot flush ": 2.287684729266098, "Hyphaema ": 377.29541831882256, "Leukopenia ": 2.059640393139203, "Malignant neoplasm progression ": 23.794316321203663, "Metastases to bone ": 76.68625987070743, "Metastases to liver ": 9.335836788883592, "Metastases to lymph nodes ": 58.64291724211469, "Metastases to spine ": 65.18818324664026, "Metastasis ": 22.875354779777588, "Neuropathy peripheral ": 5.302232128884639, "Neutropenia ": 5.358074142441842, "Neutrophil count decreased ": 8.616869479222915, "Osteonecrosis of jaw ": 17.032282791715605, "Platelet count decreased ": 3.5686743213201964, "Prostate cancer ": 27.93142400814743, "Prostate cancer metastatic ": 939.8044844651956, "Prostatic specific antigen increased ": 170.76217460249023, "Sepsis ": 3.73342175975934, "Thrombocytopenia ": 3.0246419270991667, "Treatment failure ": 2.291063841935272, "Urinary retention ": 3.253260962752495} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/218.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/218.json new file mode 100644 index 00000000000..e9b3024c273 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/218.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 9.046682715422463, "Ageusia ": 2.0212394898688397, "Alanine aminotransferase increased ": 3.041383162960215, "Amylase increased ": 3.057318185318336, "Anal fistula ": 7.979772157139022, "Aortic dissection ": 5.651897475790106, "Ascites ": 3.794491057270093, "Aspartate aminotransferase increased ": 3.6081366697251753, "Biliary obstruction ": 6.74505223900663, "Blood albumin decreased ": 3.550104651418957, "Blood calcium decreased ": 3.887987592434971, "Blood magnesium decreased ": 4.089025199040412, "Blood pressure increased ": 3.6499840314068215, "Blood thyroid stimulating hormone increased ": 11.051661152142914, "Bone lesion ": 8.067660968932168, "Cancer pain ": 27.41865617305037, "Cholangitis ": 6.353758020564221, "Cholecystitis ": 2.289180729189178, "Clear cell renal cell carcinoma ": 21.104395247704208, "Colitis ": 2.1689359322287887, "Constipation ": 3.1193502444069714, "Decreased appetite ": 6.246333138449481, "Decubitus ulcer ": 3.3648240365173456, "Dehydration ": 2.6896844134199736, "Dermatitis acneiform ": 5.175131553341047, "Diarrhoea ": 5.442660711544802, "Disease progression ": 10.419967310966284, "Dry skin ": 5.450024643836324, "Dysgeusia ": 3.64250719875444, "Dysphonia ": 6.049590560859276, "Enterocolitis ": 2.977205897804604, "Gastrointestinal perforation ": 10.47929390275256, "Gastrointestinal toxicity ": 5.031957878064786, "Haemophagocytic lymphohistiocytosis ": 2.0357375667300777, "Hair colour changes ": 23.05397569835138, "Hepatic cancer ": 3.132317733957516, "Hepatic cytolysis ": 2.5096515394877303, "Hepatic encephalopathy ": 6.089680791488418, "Hepatic function abnormal ": 7.711501273654812, "Hepatocellular carcinoma ": 23.984397296438274, "Hepatotoxicity ": 3.343523441009091, "Hyperkeratosis ": 13.13184889222622, "Hypertension ": 5.984146803096716, "Hyperthyroidism ": 4.9834473257923735, "Hypertransaminasaemia ": 5.466048482784253, "Hypoalbuminaemia ": 4.693687742726391, "Hypocalcaemia ": 6.104643418078428, "Hypomagnesaemia ": 7.627779476893026, "Hypothyroidism ": 28.96744611916492, "Ileus ": 2.129745645934271, "Immune-mediated enterocolitis ": 4.612208180959077, "Immune-mediated hepatic disorder ": 10.445681181034123, "Immune-mediated lung disease ": 5.670059651046584, "Impaired healing ": 4.975864512822222, "Inappropriate schedule of product administration ": 3.311076164933438, "Interstitial lung disease ": 3.473091488446198, "Intestinal metastasis ": 28.615613417368333, "Intestinal perforation ": 5.225968163636565, "Intra-abdominal fluid collection ": 12.841478638522553, "Large intestine perforation ": 9.639674328077994, "Liver disorder ": 6.030318712884438, "Liver function test increased ": 3.3861393973201386, "Lumbar vertebral fracture ": 4.972943505432412, "Lung opacity ": 3.098478607659696, "Malignant neoplasm progression ": 14.663837198358197, "Malignant pleural effusion ": 13.35405582847828, "Metastases to adrenals ": 12.398751952132695, "Metastases to bone ": 16.261267148832726, "Metastases to central nervous system ": 9.843372525467856, "Metastases to liver ": 5.536644643945167, "Metastases to lung ": 16.957870119289613, "Metastases to lymph nodes ": 5.65517235426344, "Metastases to pancreas ": 55.95373952908467, "Metastases to peritoneum ": 5.543007576096178, "Metastases to spine ": 12.997056285401468, "Metastasis ": 2.8260810925846016, "Metastatic renal cell carcinoma ": 14.596056886098031, "Mucosal inflammation ": 11.877159368091853, "Nephrotic syndrome ": 5.8287386631001405, "Off label use ": 2.0159166403217985, "Oral mucosal blistering ": 2.298622037959301, "Oral pain ": 4.216097954438656, "Osteonecrosis of jaw ": 22.022776711413727, "Palmar-plantar erythrodysaesthesia syndrome ": 62.66580624189505, "Performance status decreased ": 3.6771202130970737, "Peripheral ischaemia ": 4.066078301618449, "Platelet count decreased ": 3.0688971239128597, "Pleural effusion ": 2.4287924215629757, "Pneumatosis intestinalis ": 9.93382171689049, "Pneumonia aspiration ": 2.0205643439815897, "Pneumonia bacterial ": 3.594198981308985, "Pneumothorax ": 2.567507490406236, "Portal vein thrombosis ": 4.838309795451629, "Posterior reversible encephalopathy syndrome ": 4.379493568592375, "Product prescribing issue ": 4.451519699639776, "Protein urine present ": 12.794677353374064, "Proteinuria ": 26.788767351491767, "Pulmonary embolism ": 2.137290749964777, "Pulmonary mass ": 2.6558922215860323, "Renal cancer ": 4.805335307821271, "Renal cancer metastatic ": 39.13278595518814, "Renal cell carcinoma ": 63.30461049153871, "Renal cell carcinoma recurrent ": 143.73835234563762, "Renal impairment ": 2.6512049408186207, "Skin disorder ": 2.2747540871832346, "Skin exfoliation ": 2.4074806347671776, "Skin fissures ": 2.577923457609308, "Skin toxicity ": 13.87898244910454, "Skin ulcer ": 8.120795049257552, "Small intestinal perforation ": 18.60630996275087, "Stomatitis ": 12.120922883337869, "Taste disorder ": 15.592530148089512, "Thyroid disorder ": 6.274420198919708, "Thyroid hormones increased ": 19.111157908554137, "Thyroiditis ": 9.30495728638366, "Tooth disorder ": 3.4531111992285406, "Tumour haemorrhage ": 8.396707796121122, "Tumour necrosis ": 19.21074184229666, "Weight decreased ": 4.01858201042941} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/219.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/219.json new file mode 100644 index 00000000000..ef798eabef9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/219.json @@ -0,0 +1 @@ +{"Blood HIV RNA increased ": 190.97613193718212, "Depressed mood ": 5.646975128061232, "Discomfort ": 2.8708342729653125, "Drug level decreased ": 36.412762699084695, "Feeling hot ": 2.3422892230098125, "Inappropriate schedule of product administration ": 3.686343955482892, "Injection site nodule ": 86.06832264683266, "Injection site pain ": 10.967564639171965, "Injection site reaction ": 4.021881858591831, "Injection site swelling ": 2.195539606297466, "Pain ": 2.297679117049065, "Pathogen resistance ": 184.0805572413363, "Suicidal ideation ": 2.390588825279849, "Treatment failure ": 4.669278648627319, "Treatment noncompliance ": 8.945569614505716, "Viral load increased ": 207.4362275517437, "Viral mutation identified ": 277.473330570674, "Virologic failure ": 308.41636702520475, "Wrong technique in product usage process ": 5.292154298730349} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/22.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/22.json new file mode 100644 index 00000000000..0e55ab59179 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/22.json @@ -0,0 +1 @@ +{"Acute generalised exanthematous pustulosis ": 8.913034987531725, "Acute kidney injury ": 2.15178867472212, "Acute myocardial infarction ": 3.4894149315316, "Alanine aminotransferase increased ": 3.390804437383316, "Altered state of consciousness ": 6.030206563666552, "Aspartate aminotransferase increased ": 3.0329275753086717, "Bladder cancer ": 23.641552064340974, "Blood alkaline phosphatase increased ": 2.145710677522501, "Blood creatine phosphokinase increased ": 2.284566022785265, "Blood glucose decreased ": 9.874235775866737, "Blood glucose fluctuation ": 4.793153217274795, "Blood glucose increased ": 6.531088396334462, "Blood lactate dehydrogenase increased ": 2.7912249829889437, "Blood potassium decreased ": 3.094570723585333, "Blood urea increased ": 2.704378260067727, "Cardiac failure ": 3.260921608008581, "Cardiac failure congestive ": 9.667450362437316, "Cardiomegaly ": 11.787601472968312, "Cataract ": 6.792442457169299, "Cold sweat ": 3.240249888390692, "Coronary artery disease ": 7.206214271665215, "Dehydration ": 2.0219064593827034, "Depressed level of consciousness ": 3.0322508710405143, "Diabetes mellitus inadequate control ": 10.314417524568984, "Diabetic ketoacidosis ": 9.57211123719186, "Drug interaction ": 3.013931374908641, "Fluid retention ": 9.47395991303104, "Gamma-glutamyltransferase increased ": 4.159142762667941, "Gastrooesophageal reflux disease ": 2.4204642150151243, "Glycosylated haemoglobin increased ": 10.490180977232145, "Haemoptysis ": 2.2807410413479507, "Hepatic cirrhosis ": 4.167640976238321, "Hepatic failure ": 3.316929287405668, "Hepatic function abnormal ": 3.044585180215502, "Hepatic steatosis ": 4.236753654067889, "Hiatus hernia ": 6.222411685293688, "Hyperglycaemia ": 2.503913701173462, "Hypoglycaemia ": 19.16392981556364, "Hypoglycaemic coma ": 12.834957152131125, "Incorrect dose administered ": 2.120190454793858, "Interstitial lung disease ": 2.4141536791469664, "Irritable bowel syndrome ": 5.018076396068219, "Lactic acidosis ": 3.958809395203219, "Left ventricular hypertrophy ": 14.494051311241712, "Liver disorder ": 3.548193830579446, "Liver injury ": 4.949751787472818, "Macular oedema ": 13.124275732943987, "Medication error ": 4.340907312744745, "Mental impairment ": 3.008330778334653, "Metabolic acidosis ": 2.613109270406352, "Multiple allergies ": 34.3031300088349, "Myocardial infarction ": 3.5967436696322275, "Non-cardiac chest pain ": 35.88399149032056, "Oedema ": 4.965627294272026, "Oedema peripheral ": 3.845394188213933, "Pancreatic carcinoma ": 3.04327444927231, "Pancreatitis ": 2.014278443396581, "Pleural effusion ": 2.096929839241975, "Pulmonary oedema ": 5.180907871814076, "Reflux gastritis ": 43.27318230488139, "Rhabdomyolysis ": 2.3574396541673592, "Skin ulcer ": 2.8883106553108173, "Treatment noncompliance ": 3.1333872148729798, "Urinary incontinence ": 2.7620160898155084, "Urine output decreased ": 9.787651201373915, "Weight increased ": 6.6466406298862} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/220.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/220.json new file mode 100644 index 00000000000..84abc31d0f2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/220.json @@ -0,0 +1 @@ +{"Diarrhoea ": 2.72052845206641, "Hepatocellular carcinoma ": 29.996389152386485, "Malignant neoplasm progression ": 23.020014512618467, "Palmar-plantar erythrodysaesthesia syndrome ": 27.602612950673223} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/221.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/221.json new file mode 100644 index 00000000000..7907c685c61 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/221.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 16.416231902655245, "Anaemia ": 2.665708319608646, "Anaphylactic reaction ": 3.154304234305521, "Anaphylactic shock ": 2.5660765514582184, "Anaphylactoid reaction ": 5.894912179903048, "Aphthous ulcer ": 2.2152020209205, "Ascites ": 4.495874422105774, "Back pain ": 4.11807273787603, "Blood alkaline phosphatase increased ": 2.0265810399343835, "Brain oedema ": 2.2878285002293035, "Breast cancer metastatic ": 13.844215625537611, "Bronchospasm ": 6.762408595565901, "Candida infection ": 2.6094743054828635, "Cardiogenic shock ": 2.455242648088, "Cardiotoxicity ": 20.606775732460548, "Cerebral toxoplasmosis ": 51.55851123437852, "Chest discomfort ": 2.7024169928679136, "Cyanosis ": 3.906544149440784, "Dermatitis ": 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"Creatinine renal clearance increased ": 1702.9612475917645, "Depressed level of consciousness ": 31.955032084904374, "Drug abuse ": 25.059676152125206, "Drug dependence ": 6.506951319547394, "Drug interaction ": 8.572566116896256, "Dyspnoea ": 2.4826246834346364, "Fall ": 8.56948865199568, "Hypotension ": 7.728082001329624, "Irritability ": 6.626050056784711, "Mobility decreased ": 30.252681634466477, "Multiple drug therapy ": 1276.726816297091, "Off label use ": 3.761269115147376, "Orthostatic hypotension ": 72.18348727811718, "Overdose ": 13.805918403104684, "Pain ": 2.840861513301707, "Product use in unapproved indication ": 10.42591707282712, "Renal function test abnormal ": 431.05760751341165, "Sedation ": 80.51341514140996, "Sedation complication ": 259.20720900875415, "Substance abuse ": 20.207577378223093, "Toxicity to various agents ": 10.85850513254288} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/223.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/223.json new file mode 100644 index 00000000000..5662b06cfa4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/223.json @@ -0,0 +1 @@ +{"Abdominal pain ": 5.518784455635757, "Blood pressure increased ": 10.683176443952298, "Completed suicide ": 34.59229557601386, "Drug interaction ": 6.50988286193747, "Drug intolerance ": 13.948528772249734, "Hypophagia ": 62.20750315514399, "Malignant neoplasm progression ": 9.729671495002776, "Renal impairment ": 11.760902851329568, "Toxicity to various agents ": 28.557720540389333} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/224.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/224.json new file mode 100644 index 00000000000..e87baa49c87 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/224.json @@ -0,0 +1 @@ +{"Drug interaction ": 7.524376428884468} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/225.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/225.json new file mode 100644 index 00000000000..5336c97f907 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/225.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.8529307959035943, "Asthma ": 21.40505444473037, "Asthma-chronic obstructive pulmonary disease overlap syndrome ": 383.5234770406913, "Bronchiectasis ": 39.18518846424416, "Chronic obstructive pulmonary disease ": 6.230710300258888, "Deep vein thrombosis ": 3.876863225205865, "Depression ": 9.045427258831229, "Diabetes mellitus ": 25.52477491856165, "Diabetic ketoacidosis ": 29.23219617567595, "Euglycaemic diabetic ketoacidosis ": 78.75619550834354, "Full blood count abnormal ": 63.30852326924861, "Gastrooesophageal reflux disease ": 29.983030457329612, "Glycosylated haemoglobin increased ": 16.69390288220819, "Hallucination, auditory ": 31.4351166178976, "Hallucination, visual ": 19.81392393494083, "Hyperglycaemia ": 25.853280399146083, "Hypoacusis ": 27.64660658007411, "Hypoglycaemia ": 9.884787460127573, "Inappropriate schedule of product administration ": 2.8294218193359, "Ketoacidosis ": 34.979973407299255, "Lactic acidosis ": 7.561294628413499, "Loss of personal independence in daily activities ": 9.182070803183922, "Lung disorder ": 6.6244199844684335, "Metabolic acidosis ": 12.955663861865364, "Multiple allergies ": 82.72575419753434, "Mycobacterial infection ": 180.1345642652421, "Obesity ": 19.6982147703357, "Obstructive airways disorder ": 16.508213335505754, "Product prescribing error ": 30.022121513609054, "Productive cough ": 7.393231004927482, "Psychotic disorder ": 16.020176613031254, "Pulmonary embolism ": 2.424857553112984, "Renal impairment ": 2.391776707525742, "Respiratory failure ": 4.26297639439913, "Sleep disorder due to a general medical condition ": 50.41984522865183, "Suicidal ideation ": 5.303744612705502, "Type 2 diabetes mellitus ": 85.63184190946521, "Wheezing ": 13.058257671473092} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/226.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/226.json new file mode 100644 index 00000000000..ad7848aa2e3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/226.json @@ -0,0 +1 @@ +{"Cellulitis ": 27.599986625047823, "Condition aggravated ": 6.664073304317863, "Drug ineffective ": 2.2202567406657847, "Gastrointestinal haemorrhage ": 5.74002712676863, "Growth retardation ": 397.05889983740735, "Muscle abscess ": 1507.303276494352, "Osteoporosis ": 10.236979833369356, "Pneumonia streptococcal ": 1284.7406007768789, "Product use in unapproved indication ": 9.81835041445614, "Secondary adrenocortical insufficiency ": 471.6832882559841, "Staphylococcal infection ": 46.722405571583664, "X-linked lymphoproliferative syndrome ": 39948.25834000792} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/227.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/227.json new file mode 100644 index 00000000000..c13142d5a16 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/227.json @@ -0,0 +1 @@ +{"Acidosis ": 5.918102830647242, "Acquired haemophilia ": 36.188647529063, "Acute generalised exanthematous pustulosis ": 10.534539441437744, "Acute graft versus host disease ": 8.887920002633583, "Acute graft versus host disease in intestine ": 28.6298501178443, "Acute hepatic failure ": 3.8503781547884985, "Acute kidney injury ": 3.5593149057292037, "Acute myeloid leukaemia ": 10.760892781397724, "Acute respiratory distress syndrome ": 5.166730857925002, "Acute respiratory failure ": 4.904692316666604, "Adverse event ": 2.683168765401404, "Agranulocytosis ": 5.870420614198936, "Alanine aminotransferase increased ": 7.5257957914691165, "Altered state of consciousness ": 2.175993581873835, "Aspartate aminotransferase increased ": 8.136862780168219, "Aspergillus infection ": 36.52320069456084, "Bacterial infection ": 9.865618960501134, "Bilirubin conjugated increased ": 14.859991202012823, "Blood alkaline phosphatase increased ": 13.713780090403658, "Blood bilirubin increased ": 6.821098364381569, "Blood lactate dehydrogenase increased ": 10.262490026935035, "Blood potassium decreased ": 3.486112984420863, "Bone marrow failure ": 4.097566214806905, "Bronchopulmonary aspergillosis ": 43.34668494295642, "Bronchospasm ": 3.6155505404586346, "C-reactive protein increased ": 4.135054817194091, "Candida infection ": 9.611115186967746, "Cell death ": 18.21437716595152, "Central nervous system fungal infection ": 362.8002460586913, "Cholestasis ": 17.967073155052127, "Death 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2.5261554531428003, "Haemophagocytic lymphohistiocytosis ": 5.224009958049547, "Haemoptysis ": 2.0902331337684217, "Hepatic cytolysis ": 10.427131539869697, "Hepatic enzyme increased ": 3.208059300340692, "Hepatic failure ": 7.318640578884482, "Hepatic function abnormal ": 8.582483043645569, "Hepatitis ": 2.1209667609712053, "Hepatitis cholestatic ": 5.708432239383474, "Hepatitis fulminant ": 21.26528082258209, "Hepatocellular injury ": 8.8907234308636, "Hepatotoxicity ": 2.823826544931943, "Hyperbilirubinaemia ": 15.619777262057577, "Hypercalcaemia ": 6.249907200072996, "Hyperthermia ": 5.335012905184868, "Hypokalaemia ": 12.372192338058692, "Hypomagnesaemia ": 10.672039843379068, "Incorrect dose administered ": 2.364643035261509, "Jaundice ": 2.147810521158517, "Leukopenia ": 4.744077546766662, "Liver disorder ": 4.661810132107933, "Liver function test abnormal ": 3.136483807733892, "Liver injury ": 4.526709125891083, "Lymphoma ": 5.136868806508928, "Mucosal erosion ": 49.072009640340674, "Multiple organ dysfunction syndrome ": 18.17512832966768, "Myoclonus ": 6.859555454295205, "Neoplasm progression ": 3.3264228941321394, "Nephropathy toxic ": 3.8669372898050254, "Neutropenia ": 2.234345506582324, "Neutrophil count decreased ": 4.241443562328434, "Neutrophil count increased ": 24.08427274796544, "Oedema ": 2.1624607701070646, "Organ failure ": 40.14281119641697, "Pancreatitis ": 3.386882733663956, "Pancreatitis acute ": 2.73345514031356, "Pancytopenia ": 4.565684632829624, "Pathogen resistance ": 11.889853253028583, "Platelet count decreased ": 2.283673216170984, "Pneumonia ": 2.2780386140847813, "Pneumonia bacterial ": 6.20480848018251, "Prescribed overdose ": 2.001241869493409, "Pulmonary alveolar haemorrhage ": 7.533468878919313, "Purpura ": 3.0718095777952747, "Rash maculo-papular ": 14.904908925870142, "Rash morbilliform ": 6.611616611287412, "Renal impairment ": 2.298178094383299, "Respiratory distress ": 2.1981751754294296, "Respiratory 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/228.json new file mode 100644 index 00000000000..fd89ea17219 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/228.json @@ -0,0 +1 @@ +{"Hypotension ": 24.662597546329067} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/229.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/229.json new file mode 100644 index 00000000000..dae2acb7795 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/229.json @@ -0,0 +1 @@ +{"Aggression ": 4.859331363345334, "Agitation ": 7.049334037155823, "Amnesia ": 4.44433280579396, "Arthritis ": 3.9038755677663466, "Balance disorder ": 2.4363098382793997, "Basal ganglia stroke ": 1279.3293503412715, "Behaviour disorder ": 115.3863953710028, "Carotid artery stenosis ": 58.28750891002685, "Cerebral infarction ": 5.447597248538198, "Cholestasis ": 4.561354074717738, "Cognitive disorder ": 5.429828504700485, "Condition aggravated ": 2.429682633592164, "Confusional state ": 2.5346209226252983, "Cystic fibrosis ": 92.85989836104471, "Depression ": 2.024009624465931, "Disinhibition ": 46.48321769964711, "Drug abuse ": 17.285453545261063, "Drug dependence ": 6.837390555835788, "Drug ineffective for unapproved indication ": 4.169940626284627, "Drug interaction ": 10.235501168424896, "Drug level increased ": 22.37793394794624, "Drug resistance ": 2.517949753545401, "Dysarthria ": 4.220369824274967, "Dyskinesia ": 2.270507392317191, "Epilepsy ": 7.822489278520348, "Facial paralysis ": 6.029554301778748, "Fibromyalgia ": 8.89091662842922, "Hepatic enzyme increased ": 2.034996503835309, "Hepatitis ": 2.665927530092933, "Hypersexuality ": 88.82331307979784, "Intervertebral disc protrusion ": 18.95311135418196, "Lethargy ": 4.37397642326073, "Leukocytosis ": 5.210673312692011, "Liver function test abnormal ": 4.77127703389505, "Malignant cranial nerve neoplasm ": 6173.011979038408, "Metal poisoning ": 132.0096209278199, "Metastases to liver ": 4.847550654733778, "Metastases to spine ": 37.158299060983616, "Multiple-drug resistance ": 261.95180239719457, "Nerve compression ": 22.40117854522213, "Neuroblastoma recurrent ": 545.5897569526122, "Off label use ": 3.039159894896567, "Osteoarthritis ": 6.11201945184307, "Ovarian cyst ": 18.36312986808593, "Pallor ": 3.392398640244805, "Panic attack ": 3.5010844484843004, "Petit mal epilepsy ": 11.787846729550232, "Poisoning ": 9.56235383226558, "Psychotic disorder ": 8.818956485500166, "Restlessness ": 3.7255688331177415, "Retro-orbital neoplasm ": 2835.8261528496346, "Scar pain ": 228.33166332942892, "Sedation ": 9.526209467297024, "Seizure ": 6.881879532932979, "Serotonin syndrome ": 6.00236011520579, "Skin reaction ": 8.68376266470596, "Somnolence ": 3.6130702012466345, "Status epilepticus ": 11.094669733373134, "Stress ": 2.7654569226944017, "Substance abuse ": 7.623263944840117, "Substance use disorder ": 89.64153421599345, "Withdrawal syndrome ": 3.01035476977939} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/23.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/23.json new file mode 100644 index 00000000000..67934413aa0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/23.json @@ -0,0 +1 @@ +{"Blood glucose decreased ": 13.51894874585776, "Blood glucose increased ": 26.998733641471016, "Cold sweat ": 16.90067023250686, "Hyperhidrosis ": 3.458195749106008, "Hypoglycaemia ": 55.76034105879474, "Hypoglycaemic coma ": 170.29349442168697, "Liquid product physical issue ": 146.44913670522578, "Loss of consciousness ": 6.761780926959728, "Shock hypoglycaemic ": 779.2051217499967} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/230.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/230.json new file mode 100644 index 00000000000..a4d88f079a2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/230.json @@ -0,0 +1 @@ +{"Toxicity to various agents ": 16.95599428910996} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/231.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/231.json new file mode 100644 index 00000000000..340207e0d11 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/231.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 3.0280353143031533, "Adenocarcinoma ": 12.117343663239335, "Anaemia ": 2.2424154727298973, "Arteriospasm coronary ": 12.216730301039656, "Ascites ": 3.8488747112519217, "Bacteraemia ": 2.236781853131563, "Blood albumin decreased ": 3.430520576154891, "Blood iron decreased ": 2.862059606200239, "Blood magnesium decreased ": 8.340903484805855, "Blood pressure diastolic decreased ": 3.81934977638114, "Blood pressure systolic decreased ": 3.3573072669339576, "Bone lesion ": 16.51210738481975, "Breast cancer ": 6.423818021981213, "Breast cancer metastatic ": 33.63844507578386, "Breast cancer recurrent ": 27.46717806307184, "Breast disorder ": 15.766508143965282, "Cachexia ": 3.5900340812922424, "Carcinoembryonic antigen increased ": 14.10424306208571, "Cardiogenic shock ": 2.4753862472502237, "Cardiotoxicity ": 27.9252384050195, "Colitis ": 2.0153161900268204, "Colon cancer metastatic ": 18.17424934227769, "Colorectal cancer metastatic ": 16.005697177598748, "Cytopenia ": 5.324886618842485, "Diarrhoea ": 3.447174332154427, "Dihydropyrimidine dehydrogenase deficiency ": 182.57259841240776, "Disease progression ": 8.677030110612389, "Disease recurrence ": 2.9929378388307533, "Drug intolerance ": 2.950623862903716, "Drug-induced liver injury ": 3.481188986492185, "Ejection fraction decreased ": 4.319186885059996, "Electrolyte imbalance ": 5.072774054331535, "Enteritis ": 11.84032310285785, "Enterocolitis ": 5.486842003799529, "Faeces soft ": 3.643732549835821, "Febrile neutropenia ": 2.517304199184345, "Foetal growth restriction ": 2.512012889658638, "Gastrointestinal toxicity ": 25.20598162039343, "Gingival pain ": 2.724534529343244, "Granulocyte count decreased ": 7.505568839924707, "Granulocytopenia ": 5.69076160390638, "Groin pain ": 2.198956081251413, "Haematotoxicity ": 15.038631744374356, "Hand dermatitis ": 19.68713291527521, "Hepatic lesion ": 10.802799056407746, "Hepatotoxicity ": 4.88377091229686, "Hiccups ": 3.80699673623874, "Hyperammonaemic encephalopathy ": 6.329818278832468, "Hyperbilirubinaemia ": 2.616640240943848, "Hypercholesterolaemia ": 4.311590540912288, "Hypertransaminasaemia ": 3.922400271374701, "Hypoalbuminaemia ": 3.0858001529035177, "Hypokalaemia ": 2.2286791241588912, "Ileus ": 2.1972984756670977, "Immunosuppression ": 6.894928108034862, "Invasive ductal breast carcinoma ": 12.296788550554282, "Lacrimation increased ": 2.599719125318074, "Laryngospasm ": 6.490139241070271, "Left ventricular dysfunction ": 5.894981229938773, "Leukopenia ": 4.482413000593519, "Liver injury ": 2.124449539747236, "Lymphangiosis carcinomatosa ": 15.400149136561572, "Malignant neoplasm progression ": 12.50883496228145, "Metastases to bone ": 37.54396653800693, "Metastases to central nervous system ": 23.31138394386436, "Metastases to eye ": 86.46264186745579, "Metastases to liver ": 35.235771579763714, "Metastases to lung ": 20.936748260534216, "Metastases to lymph nodes ": 28.009540242665626, "Metastases to meninges ": 16.4393439860207, "Metastases to peritoneum ": 14.38048008724238, "Metastases to skin ": 72.23905247420778, "Metastases to spine ": 17.80566651191498, "Metastases to the mediastinum ": 47.4411592404888, "Metastasis ": 8.742747202471499, "Metastatic neoplasm ": 9.325335904707348, "Mucosal inflammation ": 12.20438660192316, "Myelodysplastic syndrome ": 4.524067430787326, "Myelosuppression ": 28.43857497139052, "Myositis ": 2.662009030050384, "Nail disorder ": 5.124982319852399, "Neoplasm progression ": 4.231867734352878, "Neuropathy peripheral ": 9.213669610811804, "Neurotoxicity ": 12.135852915879894, "Neutropenia ": 8.342434124923704, "Neutrophil count decreased ": 7.933050834892691, "Oesophagitis ": 2.9485847260199187, "Osteolysis ": 16.195629681325563, "Osteonecrosis of jaw ": 4.17964592395439, "PIK3CA-activated mutation ": 125.74100353664238, "Palmar-plantar erythrodysaesthesia syndrome ": 18.791413504171032, "Pancreatic neuroendocrine tumour ": 29.616446771874728, "Pancreatic neuroendocrine tumour metastatic ": 46.18776361163071, "Pancytopenia ": 2.6676738068405887, "Peripheral sensory neuropathy ": 7.494455365201925, "Platelet count decreased ": 6.947429745418879, "Pneumonitis ": 3.553683386549746, "Polyneuropathy ": 5.283650277506104, "Portal hypertension ": 7.229159722415427, "Posterior 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/232.json new file mode 100644 index 00000000000..082bc565f97 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/232.json @@ -0,0 +1 @@ +{"Acne ": 27.746559207382862, "Blood calcitonin increased ": 2023.5237525885243, "Blood calcium decreased ": 16.183524073014254, "Blood pressure increased ": 2.573533810819655, "Blood thyroid stimulating hormone increased ": 18.479056598280355, "Carcinoembryonic antigen increased ": 73.06501686625204, "Dehydration ": 2.156403652185406, "Diarrhoea ": 4.9485657453956255, "Disease progression ": 6.099002914542631, "Dry skin ": 9.078980022181668, "Electrocardiogram QT prolonged ": 42.41802507870104, "Hospitalisation ": 7.2893515022466335, "Hypertension ": 3.246513604072756, "Hypocalcaemia ": 13.812540258386909, "Malignant neoplasm progression ": 2.1683079265871723, "Neoplasm progression ": 3.644448726396821, "Photosensitivity reaction ": 20.36682090496372, "Rash ": 2.633323179765928, "Skin exfoliation ": 5.543495736990219} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/233.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/233.json new file mode 100644 index 00000000000..94007093697 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/233.json @@ -0,0 +1 @@ +{"Constipation ": 3.1145794788476486, "Drug ineffective ": 4.613775495929782, "Immune thrombocytopenia ": 220.03782577967883, "Impaired quality of life ": 236.64416130164483, "Impaired work ability ": 64.17147643935897, "Loss of personal independence in daily activities ": 9.354370405041324, "Muscle spasms ": 3.6305471763679775, "Poor quality sleep ": 81.46797197332828, "Product use in unapproved indication ": 5.170875810685633, "Suicidal ideation ": 6.526078845143178, "Therapy non-responder ": 153.36883556698533, "Weight increased ": 22.949900014465992, "Withdrawal syndrome ": 17.252122727912} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/234.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/234.json new file mode 100644 index 00000000000..d8924cd3193 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/234.json @@ -0,0 +1 @@ +{"Abdominal distension ": 4.538216519995293, "Abnormal behaviour ": 3.615431389128957, "Agitation ": 5.122439129672968, "Akinesia ": 37.022900387103135, "Balance disorder ": 2.569513219974195, "Benign prostatic hyperplasia ": 14.13276579793092, "Blood chloride increased ": 66.95389642497081, "Blood creatine phosphokinase increased ": 2.0663930192786464, "Blood pressure decreased ": 2.139381728400978, "Bradykinesia ": 41.10408680633508, "Cerebral hypoperfusion ": 323.7115246479943, "Condition aggravated ": 2.538841966981786, "Confusional state ": 2.06567090394323, "Constipation ": 5.150106386113514, "Delirium ": 2.239107164397063, "Delusion ": 15.291347673380768, "Depressed mood ": 7.659685820049332, "Dopamine dysregulation syndrome ": 182.7407884871538, "Drug interaction ": 3.7482249508320775, "Drug level increased ": 4.113538364510226, "Drug withdrawal syndrome ": 2.3575503934112083, "Dry mouth ": 4.424265119600345, "Dyskinesia ": 23.339915167735445, "Dystonia ": 14.559868830160468, "Eye pruritus ": 19.940761568079747, "Fall ": 4.565679862697627, "Freezing phenomenon ": 195.7571714141756, "Gait disturbance ": 5.465816621303948, "Gambling disorder ": 56.06616473204656, "Hallucination ": 10.349545374123627, "Hallucination, auditory ": 12.768091093250442, "Hallucination, visual ": 19.09481674621866, "Head injury ": 5.496764796895023, "Hypersexuality ": 95.34058254228134, "Hypersomnia ": 4.347881225584343, "Hypotension ": 3.852557807913147, "Impulse-control disorder ": 86.50550160601635, "Incorrect dose administered ": 4.089893222747718, "Lacrimation increased ": 17.266409916684143, "Loss of personal independence in daily activities ": 5.758863028851672, "Motor dysfunction ": 11.06582596302105, "Movement disorder ": 3.965406088917108, "Muscle rigidity ": 19.930454164925457, "Musculoskeletal stiffness ": 2.4880036206940472, "Neuroleptic malignant syndrome ": 14.682078768238997, "Neutrophil count increased ": 11.9505496012003, "Nightmare ": 5.149905987150091, "Oedema peripheral ": 2.133083330380152, "On and off phenomenon ": 533.3204676001469, "Orthostatic hypotension ": 4.559789739459665, "Parkinson's disease ": 102.86727421896629, "Parkinson's disease psychosis ": 2848.169582419294, "Parkinsonian rest tremor ": 288.99640557645824, "Parkinsonism ": 13.175958269772584, "Parkinsonism hyperpyrexia syndrome ": 967.5378719692492, "Psychotic disorder ": 9.285230648564603, "Restless legs syndrome ": 6.680430600806018, "Screaming ": 12.760907059001465, "Serotonin syndrome ": 4.394180012137349, "Somnolence ": 2.0868201376493394, "Speech disorder ": 5.413786438399397, "Status epilepticus ": 4.062561850482366, "Stereotypy ": 65.55914192338523, "Stress cardiomyopathy ": 13.145547690615048, "Subarachnoid haemorrhage ": 5.683686776887623, "Sudden onset of sleep ": 110.3429559292266, "Temperature intolerance ": 11.711141254296294, "Therapeutic response shortened ": 52.16352264268834, "Tremor ": 2.1074084762489163, "Underdose ": 7.5794908981817395, "Vertigo ": 3.560182001500597, "Vitamin B12 decreased ": 228.5587609378844, "Wrong technique in product usage process ": 3.846212459437659} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/235.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/235.json new file mode 100644 index 00000000000..439e879e5a7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/235.json @@ -0,0 +1 @@ +{"Adverse drug reaction ": 158.68681068071453, "Completed suicide ": 73.08718125273737, "Death ": 30.24376155033592, "Toxicity to various agents ": 55.85553523051466} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/236.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/236.json new file mode 100644 index 00000000000..d2166ff5133 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/236.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 3.586154188603485, "Acute respiratory distress syndrome ": 4.095297045844945, "Anaemia ": 3.91475934249942, "Ascites ": 2.231609080132509, "Atypical haemolytic uraemic syndrome ": 125.2988117791388, "Blood calcium increased ": 13.519652356514186, "Blood disorder ": 13.588368742216788, "Bone marrow disorder ": 30.57406977703992, "Brain fog ": 2.364148667991097, "COVID-19 pneumonia ": 6.442341148300263, "Cardiac failure ": 7.921397964258017, "Cardiac failure acute ": 7.421852936463756, "Cardiogenic shock ": 3.787799719375313, "Cardiotoxicity ": 10.56078635281966, "Cellulitis ": 2.381042815510983, "Cerebral toxoplasmosis ": 346.38354887758703, "Cytokine release syndrome ": 6.114551900210716, "Cytopenia ": 23.260600354078083, "Deep vein thrombosis ": 2.2046150290681408, "Disease progression ": 4.80838762575627, "Ejection fraction decreased ": 4.879307666173311, "Febrile neutropenia ": 6.068337836788587, "Fibrosis ": 19.57872538891105, "Gastrointestinal disorder ": 2.1598380373926997, "Haematotoxicity ": 6.904265484684573, "Haemolytic anaemia ": 5.753997062088401, "Haemolytic uraemic syndrome ": 21.999287860977063, "Hepatic steatosis ": 3.226085907701021, "Hypogammaglobulinaemia ": 19.84885522181084, "Infection ": 2.570526223708381, "Infusion related reaction ": 4.64161664692704, "Intentional product use issue ": 15.965461379054137, "JC virus infection ": 176.87886588837085, "Leukopenia ": 2.438133215444721, "Light chain disease ": 478.0959556872116, "Lymphopenia ": 6.26311114086344, "Microangiopathic haemolytic anaemia ": 123.67520185412064, "Mucosal inflammation ": 3.4873631141885566, "Multiple organ dysfunction syndrome ": 4.016244281530759, "Myelodysplastic syndrome ": 5.280110016837126, "Myelosuppression ": 5.193264158219974, "Neuropathy peripheral ": 6.838555830819514, "Neutropenia ": 4.186292116437014, "Neutrophil count decreased ": 2.0320714775485835, "Off label use ": 6.008425233754755, "Osteolysis ": 78.98700905819479, "Pancytopenia ": 5.327846393984082, "Plasma cell leukaemia ": 126.26456772180592, "Plasma cell myeloma ": 250.1091458598949, "Plasma cell myeloma recurrent ": 310.350688266078, "Plasma cell myeloma refractory ": 656.2514909092383, "Plasmacytoma ": 185.76647810811983, "Platelet count decreased ": 3.1280912169908084, "Pleural effusion ": 3.834160665216909, "Pneumonia ": 3.281261112676458, "Pneumonia fungal ": 15.855721888869745, "Polyneuropathy ": 4.587445772602574, "Posterior reversible encephalopathy syndrome ": 5.376729770695204, "Progressive multifocal leukoencephalopathy ": 77.86589480704242, "Pulmonary arterial hypertension ": 5.5852202288959525, "Pulmonary hypertension ": 7.912097822110903, "Pulmonary oedema ": 3.3749397771239984, "Pulseless electrical activity ": 12.880417950559016, "Renal failure ": 2.457708653547597, "Respiratory failure ": 2.9526377920352505, "Respiratory tract infection ": 4.527596176327422, "Sepsis ": 4.3327896255918334, "Septic shock ": 2.0127512214655607, "Therapeutic product effect incomplete ": 3.1325303580485366, "Therapy non-responder ": 15.594602255416696, "Therapy partial responder ": 65.97417361169826, "Thrombocytopenia ": 6.240890183672321, "Thrombotic microangiopathy ": 86.20752151095459, "Tumour lysis syndrome ": 36.2736609350323, "Upper respiratory tract infection ": 2.0288176340708763} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/237.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/237.json new file mode 100644 index 00000000000..943ac3d1366 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/237.json @@ -0,0 +1 @@ +{"Accidental exposure to product ": 26.793883643369128, "Acne ": 18.9497138153202, "Aggression ": 10.926777059125843, "Akathisia ": 79.92834982480295, "Blood prolactin increased ": 136.79080639331687, "Cardiac arrest ": 5.445184486571681, "Completed suicide ": 12.966666581606033, "Delusion ": 47.21875423481784, "Delusion of grandeur ": 687.8930317540205, "Depressed mood ": 10.236132009041684, "Drug interaction ": 3.09633169117244, "Drug resistance ": 20.66326783732023, "Dystonia ": 45.30758212232775, "Eating disorder ": 28.250140462176905, "Extrapyramidal disorder ": 39.464137526062856, "Hallucination, auditory ": 31.807090427007594, "Insomnia ": 3.116797218493686, "Lymphocyte count decreased ": 45.00167105885801, "Mental impairment ": 22.61356722903168, "Neglect of personal appearance ": 3436.650574946053, "Neutrophil count decreased ": 6.802652650612, "Off label use ": 2.043128423944615, "Orthostatic hypotension ": 20.973342188298822, "Overdose ": 3.214016692650831, "Parkinsonism ": 88.298763168657, "Pneumonia aspiration ": 22.40740346294968, "Psoriasis ": 9.92761212615132, "Red blood cell sedimentation rate decreased ": 2121.8609380328053, "Sedation ": 28.993508603164717, "Slow speech ": 193.9394958766189, "Strabismus ": 137.18559849467545, "Suicidal ideation ": 12.797176828077571, "Suspected suicide ": 147.71755676053294, "Thinking abnormal ": 52.97794678812984, "Toxicity to various agents ": 5.09512858683184, "Treatment noncompliance ": 38.12952200795059, "Vitamin D decreased ": 125.5708508860112, "Weight decreased ": 2.6920873052523704, "Withdrawal syndrome ": 13.889161987240223} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/238.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/238.json new file mode 100644 index 00000000000..d8e08b5b95b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/238.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 42.75859542468945, "Acute respiratory distress syndrome ": 3.9642173008982144, "Anaemia ": 2.310907027196997, "Aspergillus infection ": 17.246744755243064, "B-cell lymphoma recurrent ": 235.7076294463422, "BK virus infection ": 25.8132013532908, "Bacteraemia ": 11.825149944179778, "Bacterial infection ": 9.056731761608964, "Blood lactate dehydrogenase increased ": 8.406682324824763, "Bone lesion ": 62.60948007864048, "Bronchopulmonary aspergillosis ": 16.246830411481817, "Candida infection ": 5.469791678663731, "Clostridium difficile colitis ": 11.386443904039048, "Colitis ": 7.993067130491874, "Cystitis haemorrhagic ": 15.226128801722451, "Cytomegalovirus infection ": 5.424477503338146, "Cytomegalovirus infection reactivation ": 42.78955912100677, "Cytopenia ": 24.80399215363396, "Diffuse large B-cell lymphoma ": 31.67731317669775, "Diffuse large B-cell lymphoma recurrent ": 205.6403978976627, "Diffuse large B-cell lymphoma refractory ": 69.82304652318464, "Disease progression ": 23.759761268715145, "Disease recurrence ": 8.6425599556636, "Enteritis ": 33.228963411339805, "Epstein-Barr virus infection reactivation ": 30.197945431269453, "Febrile neutropenia ": 36.17453827670129, "Fungal infection ": 7.79750429337409, "Gastric cancer ": 7.934386489609373, "Gastrointestinal toxicity ": 20.46131854364733, "Graft versus host disease ": 19.98814560118569, "Granulocytopenia ": 6.7464046521267225, "Haematotoxicity ": 91.91135750287236, "Hepatic cyst ": 29.015323312332637, "Hepatitis B reactivation ": 15.516634258955971, "Hepatitis acute ": 6.311460372249967, "Hepatotoxicity ": 4.956630564305426, "Hodgkin's disease ": 33.858763843380395, "Hodgkin's disease recurrent ": 575.0677120621181, "Ill-defined disorder ": 4.719764665112564, "Infection ": 3.252099430036429, "Intentional product use issue ": 3.608205769563999, "JC virus infection ": 126.61304747228668, "Kaposi's sarcoma ": 40.38646349054193, "Klebsiella bacteraemia ": 173.3695267637119, "Lymphoma ": 18.73150043133445, "Lymphopenia ": 7.681563915256989, "Malignant neoplasm progression ": 2.3766976935474866, "Mantle cell lymphoma recurrent ": 533.6099424136872, "Metastatic lymphoma ": 162.38853222426616, "Mucosal inflammation ": 34.98697437223768, "Myelodysplastic syndrome ": 81.4027984094622, "Myelodysplastic syndrome with excess blasts ": 187.05989123202315, "Myelosuppression ": 3.967085255369893, "Nephropathy toxic ": 4.777767750232702, "Neuropathy peripheral ": 2.3385235808468554, "Neutropenia ": 4.235864003759994, "Neutropenic sepsis ": 42.005298328183, "Neutrophil count decreased ": 2.2197928452518907, "Non-Hodgkin's lymphoma ": 56.93476936728541, "Non-Hodgkin's lymphoma recurrent ": 567.372300187744, "Off label use ": 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/239.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/239.json new file mode 100644 index 00000000000..59f8bf25714 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/239.json @@ -0,0 +1 @@ +{"Abdominal infection ": 73.40130016887204, "Acinetobacter infection ": 47.24532103793901, "Acute generalised exanthematous pustulosis ": 17.754355552551747, "Acute myeloid leukaemia ": 3.762917777509261, "Acute respiratory distress syndrome ": 8.445803643022145, "Acute respiratory failure ": 3.2844794747513832, "Arthritis bacterial ": 15.579829609146616, "Arthritis fungal ": 633.1345390859295, "Aspergillus infection ": 123.17096430585688, "Atrial fibrillation ": 2.478584467151659, "Bacteraemia ": 9.115324444665276, "Blood alkaline phosphatase increased ": 6.283481770821517, "Blood bilirubin increased ": 5.071409616957467, "Blood culture positive ": 62.59636559945123, "Bronchopulmonary aspergillosis ": 56.8478223562099, "Candida infection ": 41.04627990913524, "Candida sepsis ": 51.16930604706874, "Cellulitis ": 2.901197558477645, "Central nervous system fungal infection ": 574.5119028097828, "Cerebral aspergillosis ": 235.96961035641752, "Cholestasis ": 3.527023443307823, "Chorioretinitis ": 63.39071887548951, "Circulatory collapse ": 2.049489649751181, "Condition aggravated ": 2.372097256304457, "Cutaneous calcification ": 623.8498639281297, "Cytomegalovirus infection ": 8.666116507746466, "Deafness neurosensory ": 13.223666380999967, "Disseminated intravascular coagulation ": 6.919115430306952, "Drug ineffective ": 7.000879403279328, "Drug ineffective for unapproved indication ": 15.407117213745275, "Drug level decreased ": 12.284408923300033, "Drug reaction with eosinophilia and systemic symptoms ": 3.906726929173579, "Drug resistance ": 29.75388852693252, "Drug-induced liver injury ": 4.901527538208074, "Enterococcal infection ": 41.98246259459722, "Enterocolitis ": 11.729271279627609, "Eosinophilia ": 3.2641881468700875, "Febrile neutropenia ": 5.0771209293157264, "Fungaemia ": 207.0090693552395, "Fungal endocarditis ": 385.0219473762471, "Fungal infection ": 22.41872311631253, "Fusarium infection ": 178.7844656559994, "Gamma-glutamyltransferase increased ": 2.0420539005657545, "Graft versus host disease ": 7.052988596759614, "Haematocrit decreased ": 10.08771034552078, "Haemophagocytic lymphohistiocytosis ": 7.296665380041955, "Haemoptysis ": 3.125288015284393, "Hepatic cytolysis ": 2.7210209117409585, "Hepatic failure ": 3.873910618107945, "Hepatic function abnormal ": 2.3528226303033843, "Hepatotoxicity ": 9.668283011896508, "Hydrocephalus ": 10.15174630840824, "Hyperbilirubinaemia ": 6.6184060113658045, "Hypercapnia ": 19.25129509686071, "Hypervolaemia ": 8.447805013972856, "Hypoalbuminaemia ": 15.573376294223124, "Hypokalaemia ": 3.2962384201566173, "Hypomagnesaemia ": 6.368665930082398, "Hypoxia ": 3.275082463322547, "Infection ": 2.241306870191206, "Jaundice cholestatic ": 7.665421988098072, "Leukaemia recurrent ": 36.85167843717864, "Liver function test abnormal ": 2.9071983011082634, "Liver function test increased ": 3.473224613704249, "Lower respiratory tract infection fungal ": 314.3160854528656, "Mucormycosis ": 130.04818223746466, "Multiple organ dysfunction syndrome ": 24.598947909825156, "Multiple-drug resistance ": 6.244033658629087, "Nephropathy toxic ": 10.695950586667625, "Neurological decompensation ": 22.90979267784319, "Neutropenia ": 2.536129748331577, "Oral candidiasis ": 5.516021599530959, "Ototoxicity ": 35.92219244618255, "Pallor ": 3.7841059764973184, "Pancytopenia ": 2.709874113172724, "Parenteral nutrition associated liver disease ": 407.845926029848, "Pathogen resistance ": 42.36796436158664, "Pharyngitis ": 6.454624956109873, "Pneumocystis jirovecii infection ": 53.62121961048446, "Pneumonia ": 2.266062260788043, "Pneumonia bacterial ": 8.66790693928, "Product use in unapproved indication ": 3.5786553241074825, "Pseudomonas infection ": 32.45388870286651, "Pulmonary mass ": 6.206885209668884, "Rash maculo-papular ": 9.530723214285532, "Renal failure ": 2.358619087469169, "Renal impairment ": 2.1031337202709337, "Respiratory distress ": 2.833815884556932, "Respiratory failure ": 6.748771565181686, "Scedosporium infection ": 146.56999985542103, "Sepsis ": 7.145030027663128, "Septic shock ": 22.75027581385154, "Skin exfoliation ": 3.5865656506980783, "Skin lesion ": 5.240745149143815, "Skin necrosis ": 6.663962703438559, "Stenotrophomonas infection ": 150.69390469640794, "Streptococcal infection ": 29.846691693096474, "Systemic candida ": 100.571596874052, "Systemic mycosis ": 97.9650393519305, "Tachypnoea ": 2.365878417501478, "Therapy non-responder ": 9.570444032361396, "Toxic epidermal necrolysis ": 13.241548939717738, "Toxic skin eruption ": 4.486098956338444, "Transaminases increased ": 4.1333777356422585, "Treatment failure ": 6.390981139810413, "Trichosporon infection ": 237.0318399428488, "Unresponsive to stimuli ": 3.5960029992679075} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/24.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/24.json new file mode 100644 index 00000000000..8220f56d310 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/24.json @@ -0,0 +1 @@ +{"Abortion induced ": 7.237452877445067, "Abscess ": 8.31855174511245, "Accidental overdose ": 4.187485096400902, "Anuria ": 4.604732110523533, "Arteriosclerosis coronary artery ": 16.767488677491823, "Asphyxia ": 12.634981242525924, "Blood glucose abnormal ": 7.130757524787525, "Blood glucose decreased ": 8.137205291976633, "Blood glucose fluctuation ": 35.44021146286171, "Blood glucose increased ": 18.67705150122187, "COVID-19 pneumonia ": 10.448021533724388, "Cardiac disorder ": 2.652406787140249, "Coma ": 2.5153928242969834, "Condition aggravated ": 7.612795996865404, "Dehiscence ": 771.4370357557297, "Dermatitis allergic ": 2.4796739850653986, "Device failure ": 44.81649003706615, "Device issue ": 9.381893517130438, "Device malfunction ": 13.21741262764763, "Diabetes mellitus inadequate control ": 11.34641026278777, "Diabetic coma ": 58.117475163788185, "Diabetic foot ": 22.56599025086869, "Diabetic hyperglycaemic coma ": 121.4428010700712, "Diabetic ketoacidosis ": 6.956915140463213, "Drug hypersensitivity ": 4.199132643288808, "Exposure during pregnancy ": 3.7082263932184256, "Extra dose administered ": 8.751528734546733, "Foetal exposure during pregnancy ": 2.909382303100484, "Glycosylated haemoglobin increased ": 10.672403628470969, "Haematocrit decreased ": 2.8540721932572395, "Hepatic steatosis ": 4.572345449220898, "Hyperglycaemia ": 21.794126062401197, "Hyperinsulinaemic hypoglycaemia ": 48.3005349599956, "Hypoglycaemia ": 48.13936637651637, "Hypoglycaemic coma ": 64.03942587244862, "Hypoglycaemic seizure ": 29.959368756581004, "Hypoglycaemic unconsciousness ": 29.317153712174655, "Hypothermia ": 4.73765141438557, "Incorrect dose administered ": 3.402394032769598, "Incorrect dose administered by device ": 27.30343797426918, "Injection site abscess ": 19.445792850003738, "Injection site ulcer ": 72.07452070892896, "Insulin resistance ": 21.031783213450478, "Ketoacidosis ": 10.444151458625472, "Lactic acidosis ": 2.5535677290363106, "Lipodystrophy acquired ": 18.486994368373526, "Loss of consciousness ": 2.96696138570018, "Medication error ": 4.693481095594937, "Nikolsky's sign ": 104.10362586681872, "Pneumocystis jirovecii pneumonia ": 11.995337305180469, "Premature baby ": 4.277366932055089, "Premature delivery ": 7.798892225614347, "Product administration error ": 3.961530675818505, "Product leakage ": 7.336652671392606, "Product physical issue ": 7.995969630384268, "Product quality issue ": 10.088048977106665, "Product storage error ": 8.633175288682734, "Pulmonary infarction ": 53.37005354475439, "Respiratory alkalosis ": 90.13850669911108, "Respiratory failure ": 24.605239513214, "SARS-CoV-2 test positive ": 6.7637408373775605, "Shock hypoglycaemic ": 342.5580365368121, "Skin erosion ": 13.122778890193228, "Sopor ": 7.838605003762248, "Stevens-Johnson syndrome ": 4.597069127557772, "Superficial vein thrombosis ": 9.912164278037086, "Supraventricular tachycardia ": 11.643428819285306, "Toxic epidermal necrolysis ": 14.423900937408742, "Toxic skin eruption ": 2.936809930335765, "Treatment noncompliance ": 3.8613732750715655, "Type IV hypersensitivity reaction ": 35.18247295899008, "Wrong product administered ": 16.329528189158147, "Wrong technique in product usage process ": 3.2197153790718134} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/240.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/240.json new file mode 100644 index 00000000000..a829b4862a6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/240.json @@ -0,0 +1 @@ +{"Asthma ": 37.69826354541946, "Cystic fibrosis ": 976.0342656398344, "Drug ineffective ": 2.165753130552211, "Dyspnoea ": 6.372927458059149, "Infective pulmonary exacerbation of cystic fibrosis ": 212.1742150583465, "Loss of personal independence in daily activities ": 76.23873646718333, "Sleep disorder ": 17.36845551502997, "Sleep disorder due to a general medical condition ": 244.8819808223313, "Wheezing ": 66.6516543865157} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/241.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/241.json new file mode 100644 index 00000000000..a612a1edc09 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/241.json @@ -0,0 +1 @@ +{"Drug ineffective ": 16.541696457877734} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/242.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/242.json new file mode 100644 index 00000000000..667bd2cdeea --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/242.json @@ -0,0 +1 @@ +{"Drug ineffective ": 3.0331679315641398, "Drug interaction ": 5.223061880739655, "Drug resistance ": 42.43951397031212, "Off label use ": 4.350362785784459} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/243.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/243.json new file mode 100644 index 00000000000..6dda6efbd73 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/243.json @@ -0,0 +1 @@ +{"General physical health deterioration ": 23.64948355769369, "Hypophagia ": 129.91825049650234, "Off label use ": 2.9458778296066823, "Placental insufficiency ": 1995.0411285213304, "Staphylococcal infection ": 101.24909970862343, "Thrombocytopenia ": 11.737579113449806, "Transaminases increased ": 46.20561549648564, "Treatment failure ": 35.35237306579503} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/244.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/244.json new file mode 100644 index 00000000000..e5a7376ecc5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/244.json @@ -0,0 +1 @@ +{"Diarrhoea ": 3.027232255904707, "Drug ineffective ": 2.681462655783291, "Drug resistance ": 49.459272413470735, "Off label use ": 3.251983126536617} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/245.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/245.json new file mode 100644 index 00000000000..a9df0baf72a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/245.json @@ -0,0 +1 @@ +{"Abdominal distension ": 4.352179191775153, "Anaphylactic shock ": 14.998257129528922, "Blood calcium decreased ": 75.65609615152682, "Blood pressure decreased ": 4.6794770789746, "Bronchial hyperreactivity ": 729.1664017992144, "Drug hypersensitivity ": 4.252496186615889, "Erythema ": 2.2707003762949136, "Gastritis erosive ": 146.15983979393485, "Gastrointestinal haemorrhage ": 4.852642484573176, "Hepatic enzyme increased ": 6.024051232638052, "Hepatic function abnormal ": 12.85936133982243, "Muscle contractions involuntary ": 59.08739854093133, "Pulmonary alveolar haemorrhage ": 50.65044261465893} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/246.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/246.json new file mode 100644 index 00000000000..ffc609ca371 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/246.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.001633262400938, "Abdominal pain upper ": 2.825999186704578, "Acute kidney injury ": 3.243527694605181, "Acute myeloid leukaemia ": 3.89436213905457, "Alanine aminotransferase increased ": 2.1685728101286235, "Anaphylactic reaction ": 3.2133895808402717, "Ankylosing spondylitis ": 4.722041006679708, "Antinuclear antibody positive ": 9.359985871974756, "Areflexia ": 8.565377256697056, "Arthritis ": 3.4023720723841264, "Arthropod bite ": 29.73875828067373, "Aspartate aminotransferase increased ": 2.302460070784132, "Blood alkaline phosphatase increased ": 2.764220085297792, "Blood chloride decreased ": 35.98760026635491, "Blood cholesterol increased ": 2.949996876689563, "Blood creatinine increased ": 6.124796620013664, "Blood potassium increased ": 3.4054342737739822, "Blood pressure systolic increased ": 3.245382052519473, "Blood sodium decreased ": 5.9992140814998285, "Blood urea decreased ": 21.961234813844317, "Blood urea increased ": 14.459985007011982, "Bone erosion ": 4.877755447253628, "Bradyphrenia ": 6.6292361675819365, "Brain scan abnormal ": 99.49787068154076, "Breath odour ": 25.438864669135505, "Bronchitis ": 5.018177366407232, "Bronchospasm ": 2.5304798082742943, "Bursitis ": 2.539527983175564, "C-reactive protein abnormal ": 3.04590867013248, "C-reactive protein increased ": 8.540027514261237, "Cerebral artery thrombosis ": 40.87677108402424, "Cholelithiasis ": 8.545022484868394, "Cognitive disorder ": 2.27215470601222, "Completed suicide ": 3.807880799507685, "Cystitis ": 5.055485003510575, "Delirium ": 2.1215650104732147, "Dementia Alzheimer's type ": 8.361621715817536, "Depersonalisation/derealisation disorder ": 13.375895333531496, "Drug eruption ": 2.752022883602856, "Drug hypersensitivity ": 3.596543828674449, "Drug interaction ": 5.336741643674915, "Drug intolerance ": 4.258210336661126, "Drug level increased ": 2.765427457674132, "Drug reaction with eosinophilia and systemic symptoms ": 4.862911813198087, "Enthesopathy ": 19.02226525195053, "Euglycaemic diabetic ketoacidosis ": 9.017105327801564, "Feeling jittery ": 10.70415470702378, "Femur fracture ": 6.088412729507736, "Fibromyalgia ": 5.942398000589662, "Fluid retention ": 5.198098434574378, "Foot deformity ": 3.4266784750706885, "Frequent bowel movements ": 3.591085642591316, "Gastric ulcer ": 2.0892452753969346, "Gastric ulcer haemorrhage ": 4.920746983024274, "Gastritis ": 4.653093891295279, "Gastrointestinal disorder ": 3.429791496373627, "Gastrooesophageal reflux disease ": 5.990069125001586, "Glaucoma ": 11.661514749400643, "Granuloma ": 9.121386530223866, "Hemiplegia ": 3.5062420895187807, "Hepatic steatosis ": 3.020415781021836, "Hip fracture ": 14.259902806493685, "Hypercalcaemia ": 4.4704417593419885, "Injury ": 5.686614070471255, "Joint range of motion decreased ": 2.138890373831185, "Lactic acidosis ": 3.737386679172201, "Laryngeal papilloma ": 624.8137397924909, "Liver function test abnormal ": 2.0804162203060703, "Lymphoedema ": 14.568999832387243, "Mast cell activation syndrome ": 18.30157064051844, "Metabolic acidosis ": 2.4527901017766607, "Metabolic alkalosis ": 24.363058398203624, "Migraine ": 2.1958011650187097, "Mitral valve incompetence ": 2.9873960499119057, "Mood altered ": 4.028828927031591, "Musculoskeletal disorder ": 2.941449501240041, "Myoclonus ": 2.6012558103548904, "Necrotising fasciitis ": 11.003400090320032, "Neuropathy peripheral ": 2.483398109829168, "Nitrite urine present ": 137.6881342924125, "Oliguria ": 3.5625772667323896, "Osteoarthritis ": 4.341118862648496, "Osteomyelitis ": 10.537403215361934, "Pemphigoid ": 2.08149580985475, "Phlebitis ": 9.44461549207107, "Psoriasis ": 2.4001400884204487, "Psoriatic arthropathy ": 2.99949996631996, "Purpura senile ": 986.279486566102, "Pyelonephritis acute ": 42.67883411725485, "Pyuria ": 29.260658892586427, "Quality of life decreased ": 3.693080239636271, "Renal artery stenosis ": 180.81444083313244, "Renal failure ": 2.5725264056595822, "Renal impairment ": 2.903683261686369, "Resorption bone increased ": 313.39479916085634, "Respiratory papilloma ": 1255.7592321339732, "Road traffic accident ": 7.658578886873633, "Sciatica ": 2.841236451837871, "Septic shock ": 2.082406160609268, "Serotonin syndrome ": 3.2729065572249314, "Skin lesion ": 2.9734036878540904, "Stent placement ": 7.906886363784955, "Superficial vein thrombosis ": 11.24812065123724, "Suspected suicide ": 5.70348602968559, "Syringomyelia ": 124.53901351863097, "Tarsal tunnel syndrome ": 529.9483074308141, "Thrombophlebitis ": 9.611690427339337, "Toxicity to various agents ": 3.122081017510918, "Tubulointerstitial nephritis ": 4.84254576135494, "Unresponsive to stimuli ": 9.024377805968376, "Upper gastrointestinal haemorrhage ": 2.533230213714392, "Urinary retention ": 3.729241956348934, "Vasculitis ": 20.17738209697164, "Vertigo positional ": 20.696113086729703, "Vestibular disorder ": 43.78855048876494, "Vitamin B12 decreased ": 34.9094075788953, "Vitamin D decreased ": 8.096134432081547, "White blood cell count decreased ": 2.3331872587715963} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/247.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/247.json new file mode 100644 index 00000000000..22b64be7594 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/247.json @@ -0,0 +1 @@ +{"Acne ": 3.01348220504698, "Actinic keratosis ": 6.821366774834101, "Acute graft versus host disease ": 6.2496369119336, "Acute graft versus host disease in intestine ": 4.672818127119497, "Acute pulmonary oedema ": 2.827860188455853, "Acute respiratory distress syndrome ": 5.898368638864629, "Adenocarcinoma ": 4.048724956322976, "Adenoviral haemorrhagic cystitis ": 87.85964759676507, "Adenovirus infection ": 9.60054174381196, "Agitation postoperative ": 71.77106590409363, "Agranulocytosis ": 11.07584577854706, "Amylase increased ": 3.8808583885688095, "Anaemia ": 2.5276359176465952, "Angiopathy ": 2.288810818238165, "Anogenital warts ": 6.157952096204422, "Anti-erythropoietin antibody negative ": 12.329698044569628, "Anuria ": 2.6743739069601165, "Aphthous ulcer ": 2.773493057180294, "Aplasia pure red cell ": 12.266874612439224, "Aplastic anaemia ": 2.924830084720364, "Arthritis bacterial ": 2.0156356750894986, "Ascites ": 2.31299651160958, "Aspergillus infection ": 10.040600147633402, "Atypical mycobacterial infection ": 7.596887484437276, "Autoimmune hepatitis ": 2.20094360978529, "Azotaemia ": 3.2794539122333117, "B-cell lymphoma ": 9.695254238961295, "BK virus infection ": 34.87374907063698, "Bacteraemia ": 4.637697081020913, "Bacterial infection ": 2.689296534430722, "Bacterial sepsis ": 6.091410745386403, "Basal cell carcinoma ": 9.791812639669704, "Bicytopenia ": 8.36955315532905, "Blood creatinine abnormal ": 2.56393174908664, "Blood creatinine increased ": 4.746346279625621, "Blood disorder ": 2.663199032723325, "Blood immunoglobulin G decreased ": 7.952161995789375, "Blood iron decreased ": 4.29736613128196, "Bone marrow failure ": 5.523301355179837, "Bowen's disease ": 39.87411581662972, "Brain abscess ": 9.962954724776148, "Brain herniation ": 5.0255576621374844, "Bronchial carcinoma ": 19.87842975688542, "Bronchial disorder ": 6.214608289540192, "Bronchiectasis ": 5.704708313311393, "Bronchiolitis ": 3.08275078665354, "Bronchopulmonary aspergillosis ": 12.89187524762836, "Burkitt's lymphoma ": 38.92957899242535, "COVID-19 pneumonia ": 5.825062368821206, "Cardiac hypertrophy ": 6.840302302485608, "Cardiac tamponade ": 2.307137312288034, "Cardiopulmonary failure ": 2.2918419425225465, "Cell death ": 3.772406021083672, "Central nervous system lymphoma ": 30.72718019611704, "Central nervous system vasculitis ": 8.689757655873368, "Cerebral ischaemia ": 2.92151928464957, "Cerebral toxoplasmosis ": 10.307633460347231, "Cervix carcinoma ": 4.43430947844659, "Cholangitis ": 4.221117363111109, "Cholecystitis chronic ": 6.386970314702105, "Cholestasis ": 2.83963586216232, "Chronic allograft nephropathy ": 38.45892521330973, "Colitis ": 3.379373499537601, "Colon cancer ": 2.538120705690844, "Coma ": 3.478121286310658, "Complications of transplanted kidney ": 27.68925373464343, "Congenital aplasia ": 4.829780306012806, "Congestive hepatopathy ": 6.517876692859724, "Cryptococcosis ": 16.187594349916083, "Cushingoid ": 4.773691828589302, "Cystitis haemorrhagic ": 8.66296791371324, "Cystitis viral ": 30.51272700097987, "Cytomegalovirus chorioretinitis ": 13.930709833090246, "Cytomegalovirus colitis ": 27.404357297865914, "Cytomegalovirus enterocolitis ": 57.322939558640336, "Cytomegalovirus gastritis ": 47.88151024864813, "Cytomegalovirus gastroenteritis ": 46.21942754099628, "Cytomegalovirus hepatitis ": 22.83854452966295, "Cytomegalovirus infection ": 61.557429292983485, "Cytomegalovirus infection reactivation ": 9.14950864387576, "Cytomegalovirus syndrome ": 82.38600561826152, "Cytomegalovirus test positive ": 87.83746432207568, "Cytomegalovirus viraemia ": 48.288812454449406, "Cytopenia ": 2.9785997732511453, "Delayed graft function ": 34.52110111674956, "Dermatomyositis ": 3.8825634267607088, "Dermoid cyst ": 28.709174584390997, "Device related infection ": 2.03200452509942, "Diabetes mellitus ": 2.5526158166559805, "Diarrhoea ": 2.205666135923112, "Diffuse alveolar damage ": 10.577247903228676, "Diffuse large B-cell lymphoma ": 17.543636239494596, "Disseminated cryptococcosis ": 22.542643091369747, "Disseminated intravascular coagulation ": 3.873633575106857, "Disseminated tuberculosis ": 12.254899719968757, "Diverticular perforation ": 3.966554385145044, "Drug level decreased ": 5.639861650525777, "Drug level fluctuating ": 12.600813457827252, "Drug level increased ": 3.395631857025814, "Drug specific antibody absent ": 15.100755960136024, "Duodenal ulcer ": 2.6607221505039784, "Encephalitis ": 2.920065111984814, "Encephalitis cytomegalovirus ": 14.563323764016156, "Encephalitis herpes ": 12.591439968534626, "Encephalitis viral ": 5.906530671507574, "Encephalopathy ": 2.835192700007331, "Endocarditis ": 5.708008270847819, "Endotracheal intubation ": 2.055885020516996, "Enteritis ": 2.672440989504256, "Enteritis infectious ": 6.924872655561069, "Enterococcal infection ": 3.401247265810036, "Enterocolitis ": 4.900493811886931, "Epstein-Barr viraemia ": 8.169539732380766, "Epstein-Barr virus antibody positive ": 18.95579463412055, "Epstein-Barr virus associated lymphoma ": 43.23447531068427, "Epstein-Barr virus associated lymphoproliferative disorder ": 33.48511724642814, "Epstein-Barr virus infection ": 24.436701442912987, "Epstein-Barr virus infection reactivation ": 5.893489588889363, "Epstein-Barr virus test positive ": 56.52770006020345, "Escherichia infection ": 6.144291053759965, "Escherichia urinary tract infection ": 10.246265194721971, "External auditory canal atresia ": 97.15114321342358, "Faeces soft ": 5.716870511229147, "Fistula ": 2.123860260213246, "Focal segmental glomerulosclerosis ": 17.13933981185598, "Fungaemia ": 7.542394900674092, "Fungal infection ": 2.497603907609301, "Fungal skin infection ": 5.553304529585308, "Furuncle ": 2.562074973882546, "Gastric ulcer ": 2.777072423598667, "Gastric ulcer haemorrhage ": 2.2594542238576354, "Gastroenteritis ": 5.307408492740439, "Gastroenteritis norovirus ": 8.823006580444792, "Gastrointestinal motility disorder ": 2.145583538463665, "Gastrointestinal perforation ": 2.548105606744804, "Gastrointestinal toxicity ": 2.9074255181370234, "Gastrooesophageal reflux disease ": 3.660109447625509, "Gingival hypertrophy ": 5.944168645815715, "Glomerulonephritis ": 3.097694837447677, "Glomerulonephritis membranoproliferative ": 14.06277910495802, "Glomerulonephritis membranous ": 6.091074106028458, "Graft versus host disease ": 7.418064076304272, "Graft versus host disease in gastrointestinal tract ": 4.485700010727057, "Graft versus host disease in lung ": 16.736195093747018, "Graft versus host disease in skin ": 3.4418839790780487, "Granulocytopenia ": 3.452063718030019, "Groin infection ": 23.92621648169678, "H1N1 influenza ": 10.906384077074092, "Haemodialysis ": 5.149641458745206, "Haemodynamic instability ": 2.0857970678550046, "Haemoglobin abnormal ": 2.3802088500948595, "Haemoglobin increased ": 2.1956183740138435, "Haemolysis ": 3.0605721059360813, "Haemolytic anaemia ": 3.0735853888085813, "Haemolytic uraemic syndrome ": 11.023874493575608, "Haemophagocytic lymphohistiocytosis ": 6.778601802457466, "Haemorrhoidal haemorrhage ": 2.311765813871215, "Heart transplant rejection ": 23.19021462318545, "Hepatitis B ": 7.075289590893658, "Hepatitis C ": 2.780995653242304, "Hepatitis cholestatic ": 2.1783549978793344, "Herpes simplex ": 3.036142562647808, "Herpes virus infection ": 4.878012250783681, "Herpes zoster ": 2.003161757855574, "Herpes zoster disseminated ": 19.49743717543661, "Herpes zoster meningoencephalitis ": 23.729785859800128, "Hidradenitis ": 5.101948365812859, "Hodgkin's disease ": 3.1816551009501386, "Human herpes virus 6 serology positive ": 34.30181760294619, "Human herpesvirus 6 encephalitis ": 37.357401334036176, "Human herpesvirus 6 infection ": 7.231179077667551, "Human polyomavirus infection ": 45.997681295795374, "Hydronephrosis ": 6.18181151048279, "Hyperparathyroidism ": 7.7063217209016415, "Hyperuricaemia ": 8.262234278178871, "Hypogammaglobulinaemia ": 9.929377026422848, "Hypomagnesaemia ": 2.350438161000631, "Hypoproteinaemia ": 5.555024966948186, "IgA nephropathy ": 8.20504393231869, "Ileus ": 3.608336993972476, "Ileus paralytic ": 2.5204144742580685, "Immunodeficiency ": 2.478989542550925, "Immunosuppressant drug level decreased ": 44.13018579337084, "Immunosuppressant drug level increased ": 18.36048461702587, "Immunosuppression ": 4.006832116069288, "Impaired gastric emptying ": 2.031749997539881, "Incorrect route of product administration ": 2.466737205296296, "Increased bronchial secretion ": 2.626672810439041, "Infection ": 2.4627052796915785, "Infection in an immunocompromised host ": 54.31946965833135, "Infection parasitic ": 20.291127400644083, "Intentional product use issue ": 8.537142438057458, "Interstitial lung disease ": 2.1146259981820386, "Intestinal ischaemia ": 2.2717768058667147, "Intestinal perforation ": 3.032883335114489, "Intestinal villi atrophy ": 21.864150991807485, "JC virus infection ": 18.16431770930829, "Kaposi's sarcoma ": 17.05872921082625, "Kidney fibrosis ": 4.338562430805784, "Kidney transplant rejection ": 76.43006948542025, "Klebsiella infection ": 3.8202099405616106, "Klebsiella sepsis ": 12.720291964196132, "Kussmaul respiration ": 37.6837700343522, "Large intestinal ulcer ": 6.621788692058152, "Large intestine perforation ": 3.4359483036397087, "Left ventricular dysfunction ": 2.131584345210736, "Leukoencephalopathy ": 5.681425848949701, "Leukopenia ": 8.923749910207928, "Liver abscess ": 5.329942300116247, "Liver function test abnormal ": 2.712470878928291, "Liver transplant rejection ": 29.554386484103908, "Lung adenocarcinoma ": 3.398607704151845, "Lung disorder ": 3.921506847872158, "Lung transplant rejection ": 24.82839929098712, "Lupus nephritis ": 13.838734601732185, "Lymphadenectomy ": 7.5880545887889586, "Lymphocele ": 65.92093004617628, "Lymphoma ": 9.166852715532633, "Lymphopenia ": 5.901356450246229, "Lymphoproliferative disorder ": 25.38253063793229, "Macule ": 2.3005229126089555, "Malabsorption ": 2.306561090966368, "Meningitis ": 2.1292880044485374, "Meningitis cryptococcal ": 18.6082643096074, "Meningitis viral ": 7.48594216551238, "Metastases to lymph nodes ": 2.5345057027326523, "Microtia ": 62.236788757969975, "Mouth ulceration ": 2.3377251739106857, "Mucopolysaccharidosis I ": 250.24972189929596, "Mucormycosis ": 6.7687935101413, "Multiple organ dysfunction syndrome ": 3.8427621192294414, "Myasthenia gravis ": 2.7640399540590344, "Myelitis ": 3.2271846411120104, "Myelitis transverse ": 3.3311080675610008, "Myelodysplastic syndrome with single lineage dysplasia ": 13.780979705435357, "Necrosis ": 2.028655164016316, "Neoplasm skin ": 9.442541191957403, "Nephrectomy ": 3.7230717587577207, "Nephropathy toxic ": 5.056530041436114, "Nephrotic syndrome ": 5.160972643255575, "Neutropenia ": 4.26069146430053, "No adverse event ": 2.4419241185178486, "Nocardiosis ": 16.590317693593732, "Non-Hodgkin's lymphoma ": 5.223905296077697, "Obliterative bronchiolitis ": 6.987507970683218, "Oesophageal candidiasis ": 2.2737530876965963, "Oesophageal ulcer ": 3.877766852691498, "Oesophagitis ": 2.484503976516243, "Off label use ": 3.220427335712142, "Oliguria ": 2.090245901097928, "Opportunistic infection ": 9.029254075926865, "Osteitis ": 6.060786009989613, "Osteomyelitis ": 2.473218546425137, "Otitis media ": 2.563018743769575, "Ovarian cyst ": 10.531921526894331, "Oxygen therapy ": 3.78583408742792, "PASH syndrome ": 555.7050803405959, "Pancreatitis ": 2.4164639259746905, "Pancreatitis acute ": 2.8882362560647774, "Pancreatitis necrotising ": 8.09783630329994, "Pancytopenia ": 8.208864627071813, "Paranasal sinus abscess ": 275.8342741665905, "Parvovirus B19 infection ": 17.338062751951334, "Parvovirus B19 test positive ": 68.17961602160781, "Peritonitis ": 5.079260484300982, "Pleural effusion ": 2.033584905738471, "Pneumatosis intestinalis ": 3.451755876689333, "Pneumococcal sepsis ": 14.769015900121117, "Pneumocystis jirovecii infection ": 22.760208417529224, "Pneumocystis jirovecii pneumonia ": 17.860818541303043, "Pneumonia ": 3.336764081476845, "Pneumonia aspiration ": 8.844958478506454, "Pneumonia bacterial ": 3.974334792264212, "Pneumonia cryptococcal ": 45.17720101863723, "Pneumonia cytomegaloviral ": 22.29409306475558, "Pneumonia fungal ": 7.279963775959679, "Pneumonia klebsiella ": 6.152738908644116, "Pneumonia legionella ": 7.932109869024526, "Pneumonia pneumococcal ": 11.665934384057923, "Pneumonia pseudomonal ": 6.168940989865584, "Pneumonia viral ": 3.573527053201716, "Polyomavirus-associated nephropathy ": 204.99569829209383, "Post transplant lymphoproliferative disorder ": 74.24318279991152, "Posterior reversible encephalopathy syndrome ": 7.782395812293387, "Postoperative wound infection ": 3.968948297810744, "Progressive multifocal leukoencephalopathy ": 32.34308123787983, "Protein urine present ": 2.708384754262631, "Proteinuria ": 4.029639456439384, "Pseudomembranous colitis ": 4.966337751243146, "Pseudomonal sepsis ": 4.085297372411056, "Pseudomonas infection ": 4.114204383274852, "Pulmonary alveolar haemorrhage ": 3.9258014252236095, "Pulmonary fibrosis ": 3.012345155079541, "Pulmonary tuberculosis ": 11.212835071791746, "Pyelonephritis ": 9.60698763457576, "Pyelonephritis acute ": 9.882029668808537, "Pyoderma ": 19.34637327101921, "Pyuria ": 9.160431090205083, "Rales ": 3.083760314087169, "Red blood cell sedimentation rate abnormal ": 3.028318415208844, "Renal artery stenosis ": 10.28885856057908, "Renal impairment ": 3.4275686868485584, "Renal transplant failure ": 29.06729677770697, "Renal tubular atrophy ": 12.533345178055896, "Renal tubular disorder ": 5.9969537576087, "Renal tubular necrosis ": 4.146296729341907, "Respiratory failure ": 2.4776996901462667, "Respiratory tract congestion ": 3.065839417299037, "Respiratory tract infection ": 2.0348538575716737, "Scleroderma ": 4.643109913595381, "Sepsis ": 4.377377921705844, "Septic shock ": 4.472381845577724, "Serum sickness ": 5.164591760727684, "Skin cancer ": 8.499873104532156, "Skin papilloma ": 4.7010893277027, "Skin ulcer ": 2.135162797500428, "Sleep disorder due to general medical condition, insomnia type ": 8.224193024830127, "Small intestinal obstruction ": 3.902657034682522, "Squamous cell carcinoma ": 12.475674599889643, "Squamous cell carcinoma of skin ": 15.513792599854716, "Staphylococcal bacteraemia ": 3.0281214940116405, "Staphylococcal infection ": 3.069252521466123, "Staphylococcal sepsis ": 3.0082401415634226, "Steroid diabetes ": 19.06829886451219, "Subcutaneous abscess ": 2.3128326800366144, "Systemic inflammatory response syndrome ": 2.7147943317151264, "Systemic scleroderma ": 10.574153652848608, "Therapy partial responder ": 4.381579832242541, "Thrombocytopenia ": 2.034912854989217, "Thrombotic microangiopathy ": 18.18281222727173, "Thrombotic thrombocytopenic purpura ": 3.323645534606744, "Toxoplasmosis ": 20.368267377088618, "Transplant dysfunction ": 106.2384847158186, "Transplant failure ": 14.736080887172353, "Transplant rejection ": 70.06709724646423, "Tuberculosis ": 3.95196105175824, "Upper respiratory tract inflammation ": 9.699140790352994, "Ureteric stenosis ": 22.03720358569052, "Urinary tract infection ": 4.037406104940371, "Urinary tract infection bacterial ": 6.215936288411734, "Urinary tract infection viral ": 75.76259888905591, "Urine output decreased ": 2.9620786768585, "Urosepsis ": 4.798199892531818, "Uterine cancer ": 3.166509764761328, "Varicella ": 3.2599324921639803, "Varicella zoster pneumonia ": 38.05272509512184, "Varicella zoster virus infection ": 5.440751493405972, "Venoocclusive liver disease ": 2.8393305411658143, "Viral haemorrhagic cystitis ": 26.403661823082818, "Viral infection ": 4.294545424283374, "Vulval disorder ": 16.504554685153046, "White blood cell count decreased ": 2.2764420439661515, "Wound dehiscence ": 6.658772755013069} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/248.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/248.json new file mode 100644 index 00000000000..7850e0934d0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/248.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.213128316038894, "Aggression ": 3.2454797414966223, "Alanine aminotransferase increased ": 5.06821736970525, "Aspartate aminotransferase increased ": 4.224863391685897, "Balance disorder ": 2.378210072975129, "Blood HIV RNA increased ": 84.61754071722183, "Blood creatine phosphokinase increased ": 6.3268085511644445, "Blood creatinine increased ": 2.358429670540305, "Condition aggravated ": 2.139694542240019, "Depression ": 2.146823113076952, "Drug interaction ": 2.8602262928930893, "Drug resistance ": 10.89045383743329, "Dysphagia ": 2.249869611395156, "Enanthema ": 133.48611436397306, "Gamma-glutamyltransferase increased ": 5.677064344594642, "Glaucoma ": 18.365198130685133, "Hepatic cytolysis ": 6.362524548674013, "Hepatic enzyme increased ": 3.340333528945695, "Hepatitis B reactivation ": 37.90994644162344, "Immune reconstitution inflammatory syndrome ": 39.17421059660683, "Ischaemic stroke ": 13.789760203676, "Jaundice ": 5.3434896740701445, "Lipids increased ": 97.2135798576956, "Live birth ": 17.892309315246393, "Malaria ": 314.199920891648, "Muscle twitching ": 5.826827876328659, "Nervous system disorder ": 15.924331632167846, "Oedema ": 2.5430580199616366, "Oedema peripheral ": 2.027070091307062, "Pancytopenia ": 2.8369679267689256, "Pathogen resistance ": 34.94696541122213, "Petit mal epilepsy ": 38.55345919083141, "Prinzmetal angina ": 147.42765613363318, "Rash maculo-papular ": 5.948979686090576, "Renal impairment ": 3.5996340161768408, "Renal tubular necrosis ": 24.838953255165272, "Treatment noncompliance ": 16.09923868125667, "Viral mutation identified ": 91.43272044930563, "Virologic failure ": 42.95093565629815, "Vitreous haemorrhage ": 76.49031122004548} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/249.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/249.json new file mode 100644 index 00000000000..a410c35abca --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/249.json @@ -0,0 +1 @@ +{"Coma scale abnormal ": 449.80007570716, "Drug interaction ": 13.07460950115554} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/25.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/25.json new file mode 100644 index 00000000000..f665c7b3398 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/25.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 10.639278442296764, "Abdominal distension ": 3.04602412329072, "Abdominal pain upper ": 3.411225519294096, "Adjustment disorder with depressed mood ": 48.810600898538105, "Adrenal insufficiency ": 3.646115471151065, "Adverse drug reaction ": 7.10706464012192, "Adverse event ": 4.230755138928314, "Adverse reaction ": 20.490149599971677, "Alanine aminotransferase abnormal ": 9.996477696392612, "Allergy to chemicals ": 5.555265291000941, "Alopecia ": 9.90363161838252, "Amaurosis fugax ": 11.048218284906964, "Amnesia ": 4.040362564710142, "Ankle arthroplasty ": 86.29912269991883, "Anti-cyclic citrullinated peptide antibody ": 115.09776496810495, "Anti-cyclic citrullinated peptide antibody positive ": 50.13069383568188, "Antibody test positive ": 12.929014598384825, "Anticipatory anxiety ": 18.698497387935017, "Antinuclear antibody positive ": 3.389627332397746, "Arthritis ": 4.966033072458957, "Arthropathy ": 22.016648906359464, "Autoimmune disorder ": 19.82046646087161, "Back disorder ": 11.189783138012508, "Back injury ": 20.97498451926479, "Basal cell carcinoma ": 6.918442928061056, "Blepharospasm ": 31.39548064847843, "Blister ": 10.413889187908827, "Blood cholesterol ": 13.545587801759297, "Blood cholesterol increased ": 20.70183518423435, "Blood iron abnormal ": 2.4794232146282837, "Blood parathyroid hormone decreased ": 29.745151528815597, "Body height below normal ": 44.041831875841744, "Bone density increased ": 22.676199217951705, "Bone erosion ": 19.76518918226552, "Breast cancer stage II ": 125.36099498307053, "Breast cancer stage III ": 98.71541496978408, "Bronchiectasis ": 7.462814001381392, "Burns second degree ": 23.40455271813838, "Bursitis ": 30.92854617951778, "C-reactive protein ": 107.44238709473872, "C-reactive protein abnormal ": 48.15333941329076, "C-reactive protein increased ": 12.525830480978518, "Cardiac murmur ": 2.931889310545699, "Catarrh ": 10.963822457919322, "Chronic sinusitis ": 21.033582186701448, "Coeliac disease ": 21.00457445841432, "Colitis ": 3.715221453936108, "Colitis ulcerative ": 7.306642473457567, "Condition aggravated ": 4.790480850229275, "Confusional state ": 4.103876241969562, "Congenital anomaly ": 2.0629393666227376, "Contraindicated product administered ": 18.234577497796696, "Contraindication to vaccination ": 4.413695800156847, "Contusion ": 4.250777413430337, "Crepitations ": 2.537939052994054, "Crohn's disease ": 4.658734345125329, "Cushingoid ": 3.2172758626918685, "Dactylitis ": 2.575129266358245, "Death neonatal ": 2.1558890440770555, "Deep vein thrombosis postoperative ": 100.9902381604967, "Deformity ": 7.511963735757865, "Delirium ": 3.8279048727519664, "Depression ": 2.139216839547317, "Disability ": 11.01487995314442, "Discomfort ": 12.412892264846462, "Dislocation of vertebra ": 66.0487093083409, "Disseminated tuberculosis ": 2.220065711603383, "Drug hypersensitivity ": 6.774836574416705, "Drug ineffective ": 2.319922583054951, "Drug intolerance ": 10.019198583773363, "Drug specific antibody ": 8.83841717855985, "Drug specific antibody present ": 11.13210291171388, "Drug tolerance ": 24.904701784995314, "Drug tolerance decreased ": 25.17719076380436, "Drug-induced liver injury ": 4.09110805089593, "Dry mouth ": 3.87096804806446, "Duodenal ulcer perforation ": 45.01902211086765, "Dyspepsia ": 5.6285399700240974, "Ear infection ": 4.58662260258917, "Ear injury ": 15.368706045196216, "Enthesopathy ": 24.6243911596362, "Exostosis ": 10.687019010380975, "Exposure during pregnancy ": 4.545423019527303, "Eye injury ": 24.461604664205257, "Facet joint syndrome ": 88.47905841953924, "Faecal calprotectin increased ": 6.360529374666531, "Fear of injection ": 8.085083176756944, "Female genital tract fistula ": 23.6873120117876, "Fibromyalgia ": 19.820756048712404, "Finger deformity ": 24.87681844314307, "Folliculitis ": 26.28057589893454, "Foot deformity ": 11.47907806571818, "Foot operation ": 8.578135568763129, "Fracture delayed union ": 22.766146766580864, "Frequent bowel movements ": 12.153282138137984, "Gait inability ": 4.023355525729077, "Gastroenteritis viral ": 5.794775056059652, "Gastrointestinal bacterial overgrowth ": 3.5014332224631324, "Gastrointestinal disorder ": 4.450290548625008, "General physical health deterioration ": 6.285952389807419, "Gingival pain ": 4.39560898576439, "Glossodynia ": 25.241274263524, "Granuloma ": 3.106849179819504, "Granuloma skin ": 26.57864400273933, "Grip strength ": 15.109989719144576, "Grip strength decreased ": 19.0846999528507, "Groin abscess ": 2.570070518462994, "Haematochezia ": 3.3904797833235825, "Hand deformity ": 32.18466224308178, "Helicobacter infection ": 32.68494344561906, "Hepatic cirrhosis ": 2.612448250737179, "Hepatic enzyme increased ": 5.5895556775546815, "Hepatitis ": 2.3652135048073237, "Hepatosplenic T-cell lymphoma ": 6.724396334597728, "Hidradenitis ": 8.452485382796315, "Hip arthroplasty ": 6.0346478264545, "Human anti-human antibody test ": 35.954877412028665, "Human antichimeric antibody positive ": 68.83068999167335, "Hyperadrenocorticism ": 13.86242020610056, "Hypercalcaemia ": 3.883461725655418, "Hypercholesterolaemia ": 8.361792741822832, "Hypersensitivity ": 2.7348615230126083, "Hypocalcaemia ": 3.44490351741787, "Hypopnoea ": 5.766515764976311, "Ileal stenosis ": 4.054272166894666, "Ill-defined disorder ": 9.970955755179384, "Immunodeficiency ": 4.972039269810835, "Impaired 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"Musculoskeletal disorder ": 3.239464489598455, "Musculoskeletal pain ": 3.177389417540368, "Musculoskeletal stiffness ": 2.7490435485845675, "Nail disorder ": 2.028716930403175, "Non-alcoholic fatty liver ": 4.280030763089571, "Noninfective gingivitis ": 2.4518935993055657, "Obesity ": 7.523893958818003, "Onychomadesis ": 35.376428467098215, "Onychomycosis ": 32.21783678183156, "Oral candidiasis ": 7.326698403738829, "Oral discomfort ": 2.739430219706182, "Osteoarthritis ": 3.172244840762692, "Osteoporotic fracture ": 3.531075424269411, "Panniculitis ": 8.630721533950622, "Paraesthesia oral ": 4.87108335621482, "Parathyroid disorder ": 11.73022432182549, "Parathyroidectomy ": 5.252258124854462, "Pemphigus ": 24.43070073020857, "Pericarditis ": 5.686499454917296, "Peripheral venous disease ": 22.15822582565768, "Pityriasis rubra pilaris ": 4.959263203251201, "Plasmablastic lymphoma ": 4.401785795732926, "Polyarthritis ": 5.7244963659828425, "Porphyria acute ": 5.591640668937998, "Pregnancy ": 2.08631776103997, "Prescribed overdose ": 2.6491991862380067, "Prescribed underdose ": 5.6176672053528085, "Procedural pain ": 20.61423495256972, "Proctitis ": 20.477085463132635, "Product label confusion ": 3.917535318493809, "Product temperature excursion issue ": 12.397406859206022, "Product use issue ": 5.208295880848833, "Psoriatic arthropathy ": 15.646597914898898, "Pulmonary fibrosis ": 5.0953882977752825, "Pustular psoriasis ": 2.514843018978814, "Pyoderma gangrenosum ": 2.84020242287921, "Radiculopathy ": 16.81527406706779, "Rectal haemorrhage ": 3.683919967036604, "Red blood cell sedimentation rate ": 14.775003261985889, "Red blood cell sedimentation rate abnormal ": 13.83199416613156, "Red blood cell sedimentation rate increased ": 4.041460858897409, "Red cell distribution width decreased ": 4.9529041049976215, "Retinitis ": 25.667361731257184, "Rheumatic fever ": 37.43060745846528, "Rheumatoid arthritis ": 7.229524863126858, "Rheumatoid factor positive ": 24.497784720931406, "Rheumatoid lung ": 9.477363536977917, "Rheumatoid nodule ": 4.629907498506006, "Road traffic accident ": 2.0337425552645043, "Sacroiliitis ": 6.4446554417178525, "Sciatica ": 3.631989707946509, "Seronegative arthritis ": 2.287553969472409, "Sinusitis ": 2.3062913467358004, "Sleep disorder due to general medical condition, insomnia type ": 6.681113163450791, "Spondyloarthropathy ": 10.83815548455303, "Steroid dependence ": 60.33228946518284, "Stomatitis ": 2.2114815741302283, "Swelling ": 3.6874795842126256, "Swollen joint count increased ": 25.49882592969712, "Synovitis ": 10.90125229090614, "Systemic lupus erythematosus ": 12.65047627171225, "Takayasu's arteritis ": 7.962753158463122, "Tenosynovitis ": 4.048562447724527, "Terminal ileitis ": 3.152172183462422, "Therapeutic product effect decreased ": 5.862955601167547, "Therapeutic product effect incomplete ": 3.4474201390167263, "Therapy non-responder ": 2.5176123284837675, "Treatment failure ": 5.551489136058239, "Type 2 diabetes mellitus ": 4.1042977634987, "Ulcer haemorrhage ": 4.077708178465914, "Urinary tract disorder ": 3.202560074789494, "Vaginal discharge ": 11.706471024861564, "Vaginal flatulence ": 26.04619129250113, "Vulval disorder ": 2.6975547463442684, "Whipple's disease ": 9.21635320977166, "Wound ": 13.090026825490408, "Wound complication ": 2.285272100546647, "Wound infection ": 10.921638155910475, "X-ray abnormal ": 9.016508119717496} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/250.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/250.json new file mode 100644 index 00000000000..d0f1955cc43 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/250.json @@ -0,0 +1 @@ +{"Foetal exposure during pregnancy ": 39.82482979404303, "Foetal growth restriction ": 396.3152677772589} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/251.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/251.json new file mode 100644 index 00000000000..1f00520beb1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/251.json @@ -0,0 +1 @@ +{"Dizziness ": 5.155105603791653, "Parkinson's disease ": 365.8581108859343} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/252.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/252.json new file mode 100644 index 00000000000..de7efa5c516 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/252.json @@ -0,0 +1 @@ +{"Malignant neoplasm progression ": 14.594242325161998} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/253.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/253.json new file mode 100644 index 00000000000..8500c77ca15 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/253.json @@ -0,0 +1 @@ +{"Bradycardia ": 132.991069893136, "Hypotension ": 49.04692137701578, "Overdose ": 79.27662993296236, "Unresponsive to stimuli ": 466.9616320756938} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/254.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/254.json new file mode 100644 index 00000000000..96919982894 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/254.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.05684111721901, "Adjustment disorder with depressed mood ": 47.68692017314798, "Adverse event ": 9.47630056657221, "Bone erosion ": 55.72122966408984, "Breast cancer stage III ": 43.569845236308325, "Bursitis ": 15.908669035902443, "C-reactive protein abnormal ": 28.349040487497543, "C-reactive protein increased ": 15.29486526640891, "Contraindicated product administered ": 5.625805171944957, "Crohn's disease ": 17.213120896340417, "Drug hypersensitivity ": 4.546215026516102, "Dry mouth ": 4.220716192050152, "Exostosis ": 61.60156459260583, "Folliculitis ": 15.334742669003152, "Gait disturbance ": 3.986380168896669, "Glossodynia ": 7.101370809522758, "Hand deformity ": 11.065622066544838, "Hepatic cirrhosis ": 18.610653760146523, "Hypercholesterolaemia ": 29.157764496522365, "Illness ": 3.137524462066356, "Impaired healing ": 11.919250675325646, "Infection ": 4.241586066944304, "Intentional product misuse ": 9.408359506921531, "Joint stiffness ": 16.358608296790425, "Laryngitis ": 57.180123344778046, "Live birth ": 35.00823367625806, "Liver injury ": 10.907271545275607, "Loss of personal independence in daily activities ": 6.8156675913041225, "Musculoskeletal stiffness ": 4.0847468496939445, "Red blood cell sedimentation rate abnormal ": 73.63894661296554, "Rheumatoid arthritis ": 9.303008597753555, "Synovitis ": 16.266676474083628, "Therapeutic product effect decreased ": 9.091449399098853, "Therapeutic product effect incomplete ": 5.90620767203617, "Treatment failure ": 4.859685694399646} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/255.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/255.json new file mode 100644 index 00000000000..3b56b981cbc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/255.json @@ -0,0 +1 @@ +{"Adverse event ": 7.263108871264496, "Injection site swelling ": 2.458172360727372, "Interchange of vaccine products ": 5.423395614628828, "Neck pain ": 3.2345181669802874, "Pallor ": 6.8690288750390645, "Presyncope ": 5.612881996941176, "Syncope ": 4.246273962058561} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/256.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/256.json new file mode 100644 index 00000000000..8d5226263ee --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/256.json @@ -0,0 +1 @@ +{"Blood oestrogen increased ": 3972.331408983344, "Condition aggravated ": 11.616088748189116, "Drug interaction ": 12.14436328125141, "Drug level decreased ": 328.1129832369037, "Generalised tonic-clonic seizure ": 56.12817963761371, "Ovarian hyperstimulation syndrome ": 1249.972431842877} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/257.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/257.json new file mode 100644 index 00000000000..f36a520c8f9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/257.json @@ -0,0 +1 @@ +{"Abdominal 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"Folliculitis ": 7.631578051542689, "Haematotoxicity ": 22.83093732451928, "Hypomagnesaemia ": 20.937169901068646, "Hypotension ": 2.185794251451413, "Interstitial lung disease ": 5.76264336238349, "Leukopenia ": 5.308338791846951, "Malignant neoplasm progression ": 7.610465091458724, "Mucosal inflammation ": 12.816613870387014, "Myelosuppression ": 13.933715967767142, "Neuropathy peripheral ": 8.314807185893896, "Neurotoxicity ": 8.372217811797878, "Neutropenia ": 11.068452419675143, "Neutrophil count decreased ": 6.661346274489232, "Palmar-plantar erythrodysaesthesia syndrome ": 3.2096717802750594, "Paronychia ": 34.87132313773825, "Polyneuropathy ": 11.867715054267329, "Rash ": 2.977135524719828, "Respiratory failure ": 3.644110403263234, "Sepsis ": 3.39270863404804, "Skin fissures ": 25.5101441558486, "Skin lesion ": 4.72614953093795, "Skin toxicity ": 139.9538247996285, "Stomatitis ": 8.258065864036862, "Thrombocytopenia ": 3.968192647992335, "White blood cell count decreased ": 4.273753045488423} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/259.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/259.json new file mode 100644 index 00000000000..2843bb2e4d8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/259.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.825945050029496, "Abnormal behaviour ": 12.905389238812257, "Abnormal dreams ": 57.498055495201605, "Abnormal sleep-related event ": 8.849465175938487, "Accommodation disorder ": 2.200870636577734, "Acute myocardial infarction ": 2.836886430456195, "Acute psychosis ": 8.98584171860406, "Adjustment disorder ": 2.0974310618034138, "Adjustment disorder with depressed mood ": 2.168077461303479, "Affect lability ": 6.418778886144247, "Affective disorder ": 9.813886018239751, "Aggression ": 20.10842703355831, "Agitated depression ": 28.458013389646744, "Agitation ": 7.189002809768852, 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"Tension ": 2.9726039916013787, "Therapeutic response unexpected ": 2.291988596302023, "Thinking abnormal ": 18.17537076495831, "Thirst ": 2.370156846381854, "Tobacco user ": 122.80309758044258, "Tobacco withdrawal symptoms ": 373.64173975128256, "Tongue coated ": 3.4152138190619423, "Tongue dry ": 3.245085857609662, "Tongue erythema ": 2.6545457502267094, "Tunnel vision ": 4.359874933571327, "Urine output increased ": 2.427848163239457, "Verbal abuse ": 20.19304384989637, "Vestibular disorder ": 2.1797978962936613, "Violence-related symptom ": 54.3131394415617, "Weaning failure ": 23.47599802790567, "Withdrawal syndrome ": 4.110460527981488} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/26.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/26.json new file mode 100644 index 00000000000..06deaef6d37 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/26.json @@ 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"Pneumonia ": 2.0239026324312097, "Pneumonitis ": 6.90516272421026, "Polyneuropathy ": 8.777759897138928, "Second primary malignancy ": 35.24043607138998, "Sepsis ": 5.31194250743399, "Vascular pain ": 40.88787656818098, "White blood cell count decreased ": 5.397435728311549} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/260.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/260.json new file mode 100644 index 00000000000..5bae2ccdced --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/260.json @@ -0,0 +1 @@ +{"Alopecia ": 3.398085329742896, "Gait disturbance ": 3.641648044473112, "Neoplasm malignant ": 10.777709124109515, "Pneumonia ": 2.0334723752446258} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/261.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/261.json new file mode 100644 index 00000000000..088d4ee292c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/261.json @@ -0,0 +1 @@ +{"Anaphylactic reaction ": 3.693053332732827, "Anaphylactic shock ": 2.5377056795273143, "Apallic syndrome ": 25.90289805646156, "Arthralgia ": 2.1918877661036844, "Blister ": 23.25443792693571, "Confusional state ": 7.016580965850869, "Contraindicated product administered ": 12.315800279230569, "Contusion ": 6.856317590891874, "Drug ineffective ": 2.569663802274788, "Dyspnoea ": 2.614531148668158, "Ear pain ": 3.567740328264242, "Foetal exposure during pregnancy ": 4.142874731469938, "Folliculitis ": 87.7456234936257, "Gastrointestinal disorder ": 21.620562940783103, "Hypersensitivity ": 9.142758970373198, "Ill-defined disorder ": 47.555122045737264, "Impaired healing ": 67.00948521742104, "Infection ": 18.513057886489943, "Intentional product use issue ": 3.7152225990909153, "Irritable bowel syndrome ": 78.50191678620189, "Joint 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13.872000698377274, "Wrong product administered ": 10.970524853087676} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/262.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/262.json new file mode 100644 index 00000000000..84ce87a2d7c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/262.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 276.43165638827986, "Colorectal adenoma ": 711.9590742088476, "Gastric polyps ": 497.3030796388903, "Hodgkin's disease ": 281.84869809354905, "Hodgkin's disease recurrent ": 1654.3781031227663, "Large intestine polyp ": 157.44829188806528, "Leukaemia ": 78.27003535870135, "Myelodysplastic syndrome ": 134.23063423773536, "Pancytopenia ": 11.617859482661585, "Pulmonary fibrosis ": 31.862610923958854, "Second primary malignancy ": 223.8543905293455} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/263.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/263.json new file mode 100644 index 00000000000..bb13a0ca754 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/263.json @@ -0,0 +1 @@ +{"Atrial fibrillation ": 9.530977583864438, "Brain natriuretic peptide increased ": 273.17683769580447, "Cardiac disorder ": 14.166109860590428, "Chest discomfort ": 14.618825869856924, "Coronary artery disease ": 31.874893640405126, "Cough ": 3.2386205941605413, "Dysphonia ": 18.24035849344978, "Dyspnoea exertional ": 22.79024278950676, "Eosinophilia ": 30.398701899431316, "Exostosis ": 169.81984144562443, "Fractional exhaled nitric oxide increased ": 13346.819653084816, "Muscle spasms ": 10.699498537987708, "Myalgia ": 3.055253169759368, "Myoglobin blood increased ": 993.1636323993032, "Nasopharyngitis ": 8.868473638625566, "Obstructive airways disorder ": 55.82454169535375, "Obstructive sleep apnoea syndrome ": 248.48900100341547, "Plantar fasciitis ": 484.1335908908842, "Pneumothorax ": 69.075898608453, "Secretion discharge ": 128.6519703463677, "Sensation of foreign body ": 100.13469470087064, "Wheezing ": 13.887793868514253} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/264.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/264.json new file mode 100644 index 00000000000..5ad9488d965 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/264.json @@ -0,0 +1 @@ +{"Abdominal distension ": 42.00036500958727, "Abdominal pain ": 12.169728498754273, "Ovarian hyperstimulation syndrome ": 1086.6710242053302, "Tension ": 213.8081397999383, "Vomiting ": 2.3453199374292777} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/265.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/265.json new file mode 100644 index 00000000000..137603343b2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/265.json @@ -0,0 +1 @@ +{"Actinic keratosis ": 470.24417195106304, "Acute myocardial infarction ": 2.949585464929604, "Anxiety ": 5.495613911796524, "Basal cell carcinoma ": 130.69036397828594, "Cardiac disorder ": 7.922941329325782, "Coronary artery disease ": 4.193942586660072, "Deafness ": 2.872432561702933, "Depression ": 6.547807783288016, "Diverticulitis ": 2.856407711537741, "Drug effect less than expected ": 45.5102683415831, "Drug interaction ": 3.436527011346937, "Emotional distress ": 9.361178518236857, "Erectile dysfunction ": 15.25580309549722, "Erection increased ": 10.493819189325457, "Feeling of despair ": 34.36296800537022, "Gastrooesophageal reflux disease ": 2.1911670814768214, "Hyperlipidaemia ": 4.889486707741651, "Hypersensitivity ": 2.733820285584924, "Intentional product misuse ": 2.09179562207739, "Lentigo maligna ": 1389.5915893463423, "Libido decreased ": 14.529117802560044, "Libido increased ": 56.07065819962056, "Lymphoedema ": 8.494286139900328, "Malignant melanoma ": 1030.757229570867, "Malignant melanoma in situ ": 2984.2853286942864, "Malignant melanoma stage I ": 10055.556989065251, "Malignant melanoma stage II ": 6699.82115394077, "Malignant melanoma stage III ": 3313.018374028092, "Malignant melanoma stage IV ": 2615.4602735927106, "Melanocytic naevus ": 55.802230110504254, "Melanoma recurrent ": 467.9892252687633, "Metastases to liver ": 3.038713415793136, "Metastatic malignant melanoma ": 398.3852834812421, "Neoplasm progression ": 3.9870605567468895, "Nephrolithiasis ": 2.44809137021632, "Nodular melanoma ": 683.7731034442445, "Prostate cancer ": 14.872241062500802, "Pulmonary fibrosis ": 4.237300140028569, "Sleep apnoea syndrome ": 6.563518382862385, "Squamous cell carcinoma ": 154.86879200899787, "Superficial spreading melanoma stage unspecified ": 572.684034684605, "Therapeutic response unexpected ": 5.395926926585034} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/266.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/266.json new file mode 100644 index 00000000000..89e06712964 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/266.json @@ -0,0 +1 @@ +{"Cellulitis ": 159.32369994182676} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/267.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/267.json new file mode 100644 index 00000000000..6a45aa0fa01 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/267.json @@ -0,0 +1 @@ +{"Blister ": 44.187351627185386, "Drug eruption ": 95.08060263820587, "Erythema ": 12.910407378353987, "Erythema multiforme ": 133.40075345068618, "Lymphocytic infiltration ": 2494.937340658309, "Mucosal erosion ": 2307.4006469383025, "Multiple organ dysfunction syndrome ": 88.44252085104105, "Sepsis ": 41.55283791329928, "Staphylococcal infection ": 177.1807280797498, "Staphylococcal scalded skin syndrome ": 13749.967313847352, "Toxic epidermal necrolysis ": 142.10352587642558, "Uterine haemorrhage ": 640.7550590872742} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/268.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/268.json new file mode 100644 index 00000000000..e1473b6923d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/268.json @@ -0,0 +1 @@ +{"Abdominal lymphadenopathy ": 8.69519941681243, "Abdominal mass ": 5.354082685958196, "Abdominal tenderness ": 3.1960376968007145, "Abscess ": 2.648336107217271, "Abscess drainage ": 11.732023580390669, "Acanthosis ": 17.372580702754462, "Acid fast bacilli infection ": 34.195124713376366, "Acinetobacter infection ": 17.05424707425568, "Actinic keratosis ": 6.885296488905276, "Acute graft versus host disease ": 105.31685171796516, "Acute graft versus host disease in intestine ": 107.34010978057256, "Acute graft versus host disease in liver ": 100.81155542103345, "Acute graft versus host disease in skin ": 104.30356876756905, "Acute leukaemia ": 2.14318407398394, "Acute lymphocytic leukaemia ": 2.974401495734704, "Acute lymphocytic leukaemia recurrent ": 12.238778024425748, "Acute myeloid leukaemia ": 4.451723580644136, "Acute myeloid leukaemia recurrent ": 21.38704136798354, "Acute respiratory distress syndrome ": 2.629765594785154, "Adenoviral haemorrhagic cystitis ": 55.0830766267274, "Adenoviral hepatitis ": 29.180243734783044, "Adenovirus infection ": 41.71473126444578, "Adult T-cell lymphoma/leukaemia ": 12.747335960480354, "Aeromonas infection ": 24.17064032327501, "Alanine aminotransferase abnormal ": 2.163019012385277, "Alpha haemolytic streptococcal infection ": 14.534236189100652, "Alternaria infection ": 43.93499604294308, "Alveolar proteinosis ": 23.646736010988448, "American trypanosomiasis ": 40.18468625699976, "Amniotic cavity infection ": 6.96783505374988, "Anaplastic large cell lymphoma T- and null-cell types ": 24.40459777201293, "Aneurysm ": 3.7648758848386654, "Anogenital warts ": 6.836616304601608, "Antinuclear antibody positive ": 2.3375258538363157, "Anuria ": 3.3926519660750487, "Apgar score low ": 3.683806357713131, "Aplasia pure red cell ": 4.124159290574716, "Aplastic anaemia ": 8.521443350858325, "Areflexia ": 2.025468324129245, "Arterial disorder ": 7.349033329217061, "Arteriosclerosis ": 2.2435332283671205, "Arthropod bite ": 5.612405568893792, "Ascites ": 2.0196798875121744, "Aspergillus infection ": 23.248633266444266, "Atypical mycobacterial infection ": 7.700720085272615, "Autoimmune haemolytic anaemia ": 10.651170440571963, "Azotaemia ": 6.221864151678105, "B-cell lymphoma ": 25.711936006940807, "BK polyomavirus test positive ": 51.84362451150208, "BK virus infection ": 58.91817623696521, "Bacillary angiomatosis ": 100.68383597702528, "Bacteraemia ": 5.058912011796364, "Bacterial infection ": 6.485995642795644, "Bacterial sepsis ": 6.363071184267494, "Basal cell carcinoma ": 9.920464538804046, "Behcet's syndrome ": 34.682646402431935, "Bile duct stone ": 2.1814425739561663, "Bladder cancer recurrent ": 13.669122458058936, "Bladder irritation ": 10.79089490394596, "Bladder neoplasm surgery ": 40.06317628271132, "Bladder transitional cell carcinoma ": 15.400606430105444, "Blast cell count increased ": 4.113041541759277, "Blast cells present ": 7.083545135005069, "Blindness cortical ": 13.576604721972078, "Blood albumin decreased ": 2.307473057066554, "Blood beta-D-glucan increased ": 17.381817218889044, "Blood bilirubin increased ": 3.449422219636036, "Blood creatinine increased ": 5.633299543175313, "Blood culture positive ": 2.656992934445338, "Blood immunoglobulin G decreased ": 9.82352114689494, "Blood immunoglobulin G increased ": 3.202841931905586, "Blood lactate dehydrogenase increased ": 4.856177633997981, "Blood parathyroid hormone decreased ": 5.311412088344321, "Blood stem cell transplant failure ": 186.82590107433472, "Blood urea increased ": 3.679900669010012, "Bone cyst ": 6.870552093900566, "Bone erosion ": 3.907270422327623, "Bone marrow failure ": 4.3489546215059045, "Bone marrow transplant ": 4.330583318151476, "Bone marrow transplant rejection ": 32.51709629141625, "Bowen's disease ": 19.65715534366673, "Brain abscess ": 16.257647498583673, "Brain herniation ": 3.249463682412788, "Brain oedema ": 5.224849309408813, "Bronchiolitis obliterans syndrome ": 31.003287276204, "Bronchopulmonary aspergillosis ": 18.21929512446778, "Burkholderia cepacia complex infection ": 24.746196164018816, "Burkitt's lymphoma ": 17.537664755469716, "C-reactive protein increased ": 2.85805471323886, "CD4 lymphocytes decreased ": 3.140671820463055, "CSF pressure increased ": 9.170624640108924, "CSF protein increased ": 9.589208678323471, "CSF test abnormal ": 10.265377362486792, "CSF virus identified ": 51.96128368763689, "Cachexia ": 2.657427595565616, "Calcineurin inhibitor induced pain syndrome ": 92.2405300457676, "Cancer surgery ": 11.393975614171238, "Candida infection ": 3.49997986428728, "Candida pneumonia ": 34.3699203936446, "Capillary disorder ": 18.470432833946195, "Capillary leak syndrome ": 3.719432260322348, "Cardiomegaly ": 2.350795836701095, "Cat scratch disease ": 26.39201935018955, "Central nervous system lesion ": 7.94438388864027, "Central nervous system lymphoma ": 22.70045771742604, "Cerebral atrophy ": 2.428905173785714, "Cerebral toxoplasmosis ": 11.568456559269825, "Cerebrovascular disorder ": 2.3375258538363157, "Chimerism ": 43.03389933184699, "Cholangitis sclerosing ": 3.717529831292673, "Chorioretinopathy ": 16.615393731135896, "Chronic allograft nephropathy ": 97.94922513786184, "Chronic graft versus host disease ": 141.35209015176216, "Chronic graft versus host disease in intestine ": 94.8951821043728, "Chronic graft versus host disease in liver ": 123.3465556989358, "Chronic graft versus host disease in skin ": 108.35174259408711, "Chronic graft versus host disease oral ": 27.299926195105403, "Chronic hepatitis ": 5.617285407263406, "Chronic hepatitis C ": 4.884481624338068, "Chronic myeloid leukaemia ": 3.71340496791283, "Chronic spontaneous urticaria ": 14.607586555487766, "Clear cell renal cell carcinoma ": 11.254336318265082, "Clostridium difficile colitis ": 2.148039959202394, "Colectomy ": 6.0392319886703385, "Complications of bone marrow transplant ": 62.50440530533879, "Complications of transplanted kidney ": 68.93851548735573, "Complications of transplanted lung ": 118.51793630474916, "Computerised tomogram abnormal ": 5.873925952650038, "Concomitant disease aggravated ": 2.173669508551286, "Concomitant disease progression ": 7.485942720321299, "Congenital aplasia ": 2.907098437437819, "Coombs positive haemolytic anaemia ": 25.76180970303147, "Creatinine renal clearance decreased ": 2.339904087999549, "Cryptococcosis ": 21.697413017966483, "Cryptosporidiosis infection ": 22.85363226950199, "Cushing's syndrome ": 2.193045275967615, "Cushingoid ": 9.257074000552214, "Cutaneous T-cell lymphoma ": 19.76893075099348, "Cystitis haemorrhagic ": 22.836400861869787, "Cystitis viral ": 20.80635791361986, "Cytomegalovirus chorioretinitis ": 14.119206796792126, "Cytomegalovirus colitis ": 20.29013916433593, "Cytomegalovirus enterocolitis ": 7.936084852724999, "Cytomegalovirus gastritis ": 16.554402454853285, "Cytomegalovirus gastroenteritis ": 23.76101966861085, "Cytomegalovirus gastrointestinal infection ": 25.48893380412885, "Cytomegalovirus hepatitis ": 11.74105709348279, "Cytomegalovirus infection ": 33.98016532485754, "Cytomegalovirus infection reactivation ": 39.31315671690326, "Cytomegalovirus test ": 37.5374669093521, "Cytomegalovirus test positive ": 27.329066846936666, "Cytomegalovirus viraemia ": 22.08102360659077, "Cytopenia ": 2.3479491057831146, "Debridement ": 32.61734257162428, "Demyelinating polyneuropathy ": 3.55634035998865, "Demyelination ": 2.552343402121895, "Dengue haemorrhagic fever ": 51.84362451150208, "Dermatitis atopic ": 3.684787954937666, "Dermatitis exfoliative generalised ": 3.272540011830775, "Dermatomyositis ": 3.574179365044152, "Device related infection ": 2.1714254147972483, "Device related sepsis ": 3.856704800362588, "Dialysis ": 4.066594532207034, "Diarrhoea haemorrhagic ": 2.7545128620951265, "Diffuse alveolar damage ": 10.22910740326085, "Diffuse large B-cell lymphoma ": 10.941994272265118, "Diffuse large B-cell lymphoma stage IV ": 23.100132546211896, "Disease recurrence ": 5.8191837501328845, "Disseminated Bacillus Calmette-Guerin infection ": 12.059808396897823, "Disseminated aspergillosis ": 12.40905736141155, "Disseminated cryptococcosis ": 16.613248944557963, "Disseminated intravascular coagulation ": 3.1366446045320235, "Disseminated tuberculosis ": 11.277980945457127, "Diverticular perforation ": 2.311585052776248, "Drug ineffective for unapproved indication ": 3.2554709414612835, "Drug interaction ": 2.9537301258746105, "Drug intolerance ": 2.4100663860778337, "Drug level above therapeutic ": 2.120592527428202, "Drug level below therapeutic ": 2.767000487786216, "Drug level decreased ": 6.808993477372205, "Drug level fluctuating ": 5.701800007027876, "Drug level increased ": 7.454684392665531, "Drug resistance ": 4.202769455309068, "Eastern Cooperative Oncology Group performance status worsened ": 9.006529106562589, "Eczema herpeticum ": 6.081173944801256, "Electrocardiogram ST segment depression ": 2.116441239323388, "Electroencephalogram abnormal ": 2.8085093446800258, "Empyema ": 2.68752793048808, "Encephalitis ": 3.292285880415402, "Encephalitis cytomegalovirus ": 29.119188716507157, "Encephalitis herpes ": 20.50936311785056, "Encephalitis viral ": 15.433221330210968, "Encephalopathy ": 3.1162661956165523, "End stage renal disease ": 4.222335440280807, "Endocarditis ": 2.934373725394736, "Endotracheal intubation ": 2.610026620402992, "Engraft failure ": 46.17408515418877, "Engraftment syndrome ": 22.777587450676133, "Enterobacter infection ": 5.4239941403072605, "Enterococcal bacteraemia ": 5.221644009467364, "Enterococcal infection ": 11.269417135707396, "Enterococcal sepsis ": 11.18912388056708, "Enthesopathy ": 3.7665746743527664, "Epstein-Barr viraemia ": 32.3368581942304, "Epstein-Barr virus antibody positive ": 20.47225462023441, "Epstein-Barr virus associated lymphoma ": 27.08098622113249, "Epstein-Barr virus associated lymphoproliferative disorder ": 74.86607433169681, "Epstein-Barr virus infection ": 63.28097470157935, "Epstein-Barr virus infection reactivation ": 21.55941880681132, "Epstein-Barr virus test positive ": 15.944615154789318, "Erythrodermic psoriasis ": 7.892118892290502, "Escherichia bacteraemia ": 2.58837329841536, "Escherichia infection ": 8.968810489781816, "Escherichia sepsis ": 2.951286134139187, "Escherichia urinary tract infection ": 2.0282981349657483, "Evans syndrome ": 18.358339012790807, "Exophthalmos ": 2.371536382911132, "Extensor plantar response ": 4.021691350866382, "Extranodal marginal zone B-cell lymphoma ": 13.908532496924847, "Fear of injection ": 6.778857227510716, "Febrile neutropenia ": 2.6003322856078728, "Fibroadenoma of breast ": 34.306180628015696, "Focal segmental glomerulosclerosis ": 39.97405163896738, "Foetal disorder ": 5.291213351409764, "Foetal distress syndrome ": 4.136832615598153, "Foetal growth restriction ": 5.516318022488767, "Foetal heart rate deceleration abnormality ": 5.995518120404044, "Fungaemia ": 8.0409854190027, "Fungal infection ": 5.267264077082234, "Fungal sepsis ": 10.168812572023446, "Fungal skin infection ": 3.721347108102508, "Fungal test positive ": 11.222000889169353, "Fusarium infection ": 25.438734657666668, "Gastric mucosal lesion ": 4.3973199591706, "Gastroenteritis adenovirus ": 24.366343960983684, "Gastroenteritis norovirus ": 7.3901245090569585, "Gastrointestinal infection ": 2.0550829578357783, "Gastrointestinal mucosal disorder ": 9.960250042807528, "Generalised oedema ": 2.9182001230267924, "Gestational hypertension ": 3.70354138043252, "Gingival hypertrophy ": 55.07368826719517, "Gingival swelling ": 2.4974080511013823, "Gingivectomy ": 175.641602262016, "Glomerular filtration rate decreased ": 3.0128829487803674, "Glomerular vascular disorder ": 39.54997060207162, "Glomerulonephritis ": 5.575496494992393, "Glomerulonephritis membranoproliferative ": 11.342496122696632, "Glomerulonephritis membranous ": 15.394041420367198, "Glomerulonephritis minimal lesion ": 20.206974824428503, "Glomerulonephropathy ": 40.862364270202725, "Glomerulosclerosis ": 30.55514831674318, "Gouty tophus ": 24.132042619502297, "Graft loss ": 61.00097059465603, "Graft versus host disease ": 74.75093640227017, "Graft versus host disease in eye ": 56.84382199786557, "Graft versus host disease in gastrointestinal tract ": 94.0958374696237, "Graft versus host disease in liver ": 92.05462740404153, "Graft versus host disease in lung ": 48.49454091149225, "Graft versus host disease in skin ": 89.035771174271, "Granuloma ": 3.484937698625681, "Granuloma skin ": 7.948138457852394, "Granulomatosis with polyangiitis ": 3.9626572701266256, "Growth retardation ": 6.521487594312666, "Guttate psoriasis ": 4.641848162781707, "H1N1 influenza ": 5.092930206166092, "Haematocrit decreased ": 2.058880996940464, "Haematuria ": 3.088571850930101, "Haemodialysis ": 17.70164133292436, "Haemolysis ": 5.102358584766035, "Haemolytic anaemia ": 2.8270629597923365, "Haemolytic uraemic syndrome ": 28.36188133278254, "Haemophagocytic lymphohistiocytosis ": 16.227763247282358, "Haemorrhage intracranial ": 2.1011426325548053, "Haptoglobin decreased ": 9.716280946140808, "Head deformity ": 11.411447123407187, "Heart transplant rejection ": 112.14219591799444, "Hepatic failure ": 2.2974582072651035, "Hepatic fibrosis ": 12.088102766815824, "Hepatic lesion ": 2.170405411874695, "Hepatic mass ": 2.709496112152312, "Hepatic necrosis ": 3.517173853175943, "Hepatitis B ": 4.459396790664978, "Hepatitis B reactivation ": 7.733244841865264, "Hepatitis B surface antigen positive ": 9.287395609739743, "Hepatitis E ": 16.649135311217098, "Hepatitis viral ": 8.729161066821439, "Hepatomegaly ": 2.874387740251926, "Hepatosplenomegaly ": 9.01721319472986, "Herpes simplex ": 3.907995052831402, "Herpes virus infection ": 3.642620548615077, "Herpes zoster disseminated ": 5.826038030094606, "Hilar lymphadenopathy ": 7.195542713521421, "Hirsutism ": 32.54001191164458, "Hodgkin's disease ": 7.614481942442609, "Human ehrlichiosis ": 237.12043410869265, "Human herpes virus 6 serology positive ": 12.68645977088494, "Human herpesvirus 6 infection ": 15.831105175995434, "Human herpesvirus 6 infection reactivation ": 8.064440303491313, "Human herpesvirus 8 infection ": 51.412879327651325, "Human polyomavirus infection ": 55.181797551657, "Hydrocephalus ": 4.183203902089193, "Hydronephrosis ": 4.09998789009813, "Hyperbilirubinaemia ": 2.375467267908798, "Hyperkeratosis ": 3.7643061213894815, "Hypertension ": 2.266685107846941, "Hypertensive encephalopathy ": 6.986469870744432, "Hypertrichosis ": 17.890695130430036, "Hypervolaemia ": 2.10017371773616, "Hypoalbuminaemia ": 6.625031317786491, "Hypogammaglobulinaemia ": 6.800434074061824, "Hypomagnesaemia ": 2.3986499899020566, "Hypoproteinaemia ": 4.0967528223071135, "Hyporeflexia ": 2.313974468179848, "Idiopathic intracranial hypertension ": 5.417700424104092, "Idiopathic pneumonia syndrome ": 45.1671712987872, "IgA nephropathy ": 4.513350701188741, "Immunosuppressant drug level decreased ": 28.634089784155982, "Immunosuppressant drug level increased ": 60.65172255742176, "Immunosuppression ": 7.295618862887299, "Incorrect dosage administered ": 2.3758669490067703, "Infected skin ulcer ": 3.918392019208175, "Infection ": 2.4107438407024526, "Infection reactivation ": 11.158362676158124, "Infectious pleural effusion ": 3.4932304234943587, "Intermittent claudication ": 2.001356559354298, "Intervertebral discitis ": 2.978480134782923, "Intestinal resection ": 4.096622405457169, "Intracranial mass ": 5.063869869074814, "Intracranial pressure increased ": 4.675219172623604, "Intravascular haemolysis ": 6.554110667916862, "Iron overload ": 5.160554024960483, "JC virus infection ": 11.759142589694063, "Joint ankylosis ": 5.506056138313052, "Juvenile idiopathic arthritis ": 5.812208673927205, "Kaposi's sarcoma ": 44.73917367212656, "Keratitis ": 2.231529110007328, "Kidney fibrosis ": 32.48889372031274, "Kidney transplant rejection ": 73.96579122334492, "Klebsiella bacteraemia ": 6.348507675249137, "Klebsiella infection ": 10.273127245958964, "Laparotomy ": 10.021153245903974, "Large intestinal ulcer ": 2.872862349479948, "Large intestine perforation ": 2.3504833974897603, "Legionella infection ": 17.36339163904472, "Lesion excision ": 33.332111642137754, "Leukaemia recurrent ": 20.49041436516287, "Leukocytosis ": 2.2306462037658674, "Leukoencephalopathy ": 12.033758421331695, "Lichenification ": 31.858958687588725, "Lipids increased ": 5.762445574042518, "Lipohypertrophy ": 3.2624178034770117, "Listeriosis ": 6.404523061228796, "Liver abscess ": 3.845771368460654, "Liver transplant ": 2.644481403947702, "Liver transplant rejection ": 78.19263660444946, "Low birth weight baby ": 9.64185386958937, "Lung abscess ": 3.272928013394609, "Lung consolidation ": 5.607872863658767, "Lung infiltration ": 6.97723086569875, "Lung transplant rejection ": 70.52548890089882, "Lupus nephritis ": 6.179127761541515, "Lymphadenectomy ": 16.386548271681225, "Lymphadenitis ": 2.145858929418475, "Lymphadenopathy mediastinal ": 5.219241904700827, "Lymphocele ": 23.76558147673437, "Lymphocyte count decreased ": 2.5497531584436124, "Lymphocyte count increased ": 3.888209613798106, "Lymphocyte morphology abnormal ": 8.505879054879587, "Lymphocytic infiltration ": 11.031136436099022, "Lymphoma ": 4.771217099927423, "Lymphopenia ": 2.711468098947762, "Lymphoproliferative disorder ": 34.304720264822684, "Magnetic resonance imaging abnormal ": 3.887643206601181, "Magnetic resonance imaging head abnormal ": 9.77919968973547, "Malignant fibrous histiocytoma ": 43.63452627638474, "Marrow hyperplasia ": 5.838752940578392, "Mass ": 2.51918533570359, "Mean cell haemoglobin concentration decreased ": 3.489602736136421, "Mean platelet volume decreased ": 6.875277705809002, "Mechanical ventilation ": 10.72605917659054, "Mediastinitis ": 10.645728315859296, "Meningism ": 2.3666851241929243, "Meningitis cryptococcal ": 7.022672108143361, "Meningitis tuberculous ": 7.09766852481623, "Metapneumovirus infection ": 12.700526944892667, "Metastases to lymph nodes ": 3.0571696577427687, "Microangiopathic haemolytic anaemia ": 33.424592404565416, "Microangiopathy ": 10.988982327127031, "Microsporidia infection ": 26.45077194744592, "Monocyte count decreased ": 4.361474125001556, "Mouth ulceration ": 2.444316950741806, "Mucocutaneous leishmaniasis ": 157.71453839144132, "Mucormycosis ": 27.321440802620867, "Mucosal erosion ": 5.18729890679847, "Mucosal inflammation ": 3.784468538439572, "Mucosal ulceration ": 7.719240126966397, "Multiple organ dysfunction syndrome ": 7.57077338595741, "Mycobacterial infection ": 7.85459758922767, "Mycobacterium avium complex infection ": 4.219271145249596, "Mycobacterium chelonae infection ": 26.67661126509181, "Mycobacterium kansasii infection ": 16.892041736139973, "Myelodysplastic syndrome ": 4.769597012916603, "Myeloid leukaemia ": 9.022980588351649, "Myoglobin blood increased ": 2.556921231771057, "Myoglobinuria ": 9.311895683784783, "Myopathy ": 4.930714607294435, "Myopathy toxic ": 26.292027135629706, "Nail dystrophy ": 7.879142184593298, "Nasal septum deviation ": 4.62945995029691, "Natural killer cell count increased ": 137.52493547373126, "Necrosis ": 3.5087481883914693, "Necrotising fasciitis ": 6.421113608871963, "Neoplasm recurrence ": 2.972663130440259, "Neoplasm skin ": 10.04857319529661, "Nephrectomy ": 12.490699521236138, "Nephropathy ": 2.52099223713054, "Nephropathy toxic ": 29.705721354069723, "Nephrotic syndrome ": 15.74217162384833, "Nephroureterectomy ": 280.08380551729664, "Neuroendocrine carcinoma of the skin ": 13.375418742024529, "Neurological decompensation ": 5.577161593119884, "Neurotoxicity ": 7.172991543039554, "Neutrophil count increased ": 2.397771287751376, "Nocardiosis ": 51.32691663873011, "Nodule ": 3.1848880448234653, "Non-Hodgkin's lymphoma ": 6.213887951092764, "Normal newborn ": 5.110929506265864, "Normocytic anaemia ": 2.062297079962748, "Norovirus test positive ": 15.598157148618046, "Obliterative bronchiolitis ": 45.742529321595576, "Oesophageal candidiasis ": 3.2040538992900043, "Oliguria ": 5.668743296635772, "Opportunistic infection ": 4.641848162781707, "Oral disorder ": 2.5797796343472803, "Oral lichen planus ": 4.453144601826418, "Oral mucosa erosion ": 3.3084285036482166, "Organising pneumonia ": 3.223942193906272, "Osmotic demyelination syndrome ": 12.14502353871776, "Osteolysis ": 5.808811301899119, "Osteoporotic fracture ": 3.12623403840072, "Ototoxicity ": 3.029860238373207, "Pancytopenia ": 3.025415179280812, "Panniculitis ": 5.917115874017986, "Papillary thyroid cancer ": 11.12658135469201, "Papilloedema ": 4.102515332321778, "Papilloma viral infection ": 5.264544089488227, "Papule ": 2.8982022379645214, "Parainfluenzae virus infection ": 13.08529974351386, "Paraparesis ": 2.063595664184878, "Paroxysmal nocturnal haemoglobinuria ": 11.089954322061155, "Partial seizures ": 3.144065161274676, "Parvovirus B19 infection ": 23.78075284200802, "Pathogen resistance ": 2.2805934677175537, "Pelvic fracture ": 2.4010761102963984, "Periodontitis ": 3.0940854671494176, "Peripheral T-cell lymphoma unspecified ": 20.616843425485712, "Peritonitis ": 3.7985126196202894, "Peritonitis bacterial ": 2.959632448715252, "Phaeohyphomycosis ": 35.59377919423019, "Photodermatosis ": 8.17574779963936, "Pityriasis rubra pilaris ": 10.61846079233384, "Plasmablastic lymphoma ": 27.7436503463608, "Plasmacytoma ": 8.278193627554993, "Pleocytosis ": 7.051373543851954, "Pleural effusion ": 2.0851520573548767, "Pneumatosis intestinalis ": 9.067916952336407, "Pneumocystis jirovecii infection ": 10.4268682501703, "Pneumocystis jirovecii pneumonia ": 8.921894943169129, "Pneumomediastinum ": 9.7615020212804, "Pneumonia bacterial ": 5.559877541838443, "Pneumonia cytomegaloviral ": 33.7268938429351, "Pneumonia fungal ": 9.221449806012398, "Pneumonia klebsiella ": 5.1339691143129, "Pneumonia legionella ": 5.764023370367196, "Pneumonia pseudomonal ": 8.42508037930584, "Pneumonia staphylococcal ": 2.5929868379700505, "Pneumonia viral ": 5.06121999215259, "Pneumothorax ": 2.1047257618856654, "Polycythaemia ": 3.247333717713528, "Polymyositis ": 2.757970477445421, "Polyomavirus viraemia ": 77.04412280631654, "Polyomavirus-associated nephropathy ": 24.51253409160969, "Porokeratosis ": 27.488116975361876, "Post transplant lymphoproliferative disorder ": 114.75031611108524, "Posterior reversible encephalopathy syndrome ": 32.447985184985896, "Pre-eclampsia ": 5.486072397036593, "Pre-existing condition improved ": 3.332431046406912, "Premature baby ": 4.90229613346597, "Premature delivery ": 2.150737763809231, "Premature labour ": 8.113477383031176, "Product use in unapproved indication ": 3.803719740852984, "Progressive multifocal leukoencephalopathy ": 4.265587372359194, "Protein urine present ": 5.859650477086315, "Protein-losing gastroenteropathy ": 8.765183839157324, "Proteinuria ": 7.094904369188273, "Pseudolymphoma ": 20.223403042777708, "Pseudomonal bacteraemia ": 6.206217235159014, "Pseudomonal sepsis ": 11.934815144922675, "Pseudomonas infection ": 11.263638566533045, "Psoriasis ": 4.6271820930632535, "Psoriasis area severity index increased ": 17.632460627415607, "Pulmonary alveolar haemorrhage ": 2.7187848792074947, "Pulmonary haemorrhage ": 2.91993146703286, "Pulmonary mass ": 3.1334319840368265, "Pulmonary tuberculosis ": 7.811291026254513, "Purulence ": 4.030962722080242, "Purulent discharge ": 7.729516825093644, "Pustular psoriasis ": 7.25869109077661, "Pustule ": 2.552636511039637, "Pyelonephritis ": 2.107859766475213, "Pyoderma gangrenosum ": 12.181846287852244, "Pyogenic granuloma ": 34.19241473878414, "Quadriplegia ": 2.406121313082974, "Rales ": 3.092285092940189, "Rebound effect ": 6.328287365571042, "Red blood cell abnormality ": 5.920040566231614, "Red blood cell schistocytes present ": 80.64849201795718, "Red blood cell sedimentation rate abnormal ": 4.0826164131228655, "Red blood cell sedimentation rate increased ": 4.484392485965304, "Removal of renal transplant ": 79.03874336037859, "Renal arteriosclerosis ": 38.91404680232824, "Renal disorder ": 2.212985809177336, "Renal impairment ": 5.161179064670264, "Renal mass ": 6.632554570557144, "Renal transplant ": 4.454446597115008, "Renal transplant failure ": 87.31339586387926, "Renal tubular atrophy ": 46.32015292922189, "Renal tubular disorder ": 2.23838692003034, "Renal tubular injury ": 11.538938045787262, "Renal tubular necrosis ": 3.870891827661013, "Renal vessel disorder ": 54.98110614762541, "Respiratory failure ": 3.2409016477870294, "Respiratory syncytial virus infection ": 2.3798985565231137, "Respiratory tract infection viral ": 2.6926854621741496, "Reticulocyte count decreased ": 5.89687573917482, "Reticulocyte count increased ": 11.142792737758612, "Retinal depigmentation ": 19.471767814740115, "Retinitis ": 7.967106320598573, "Reversible cerebral vasoconstriction syndrome ": 3.1630603196520526, "Rhabdomyolysis ": 3.356471362435037, "Rheumatoid factor negative ": 16.064130920802604, "Rheumatoid nodule ": 3.744934440190772, "Rhodococcus infection ": 31.862419839963398, "Salmonellosis ": 6.850307006267866, "Sarcoma ": 4.945154177224769, "Scedosporium infection ": 33.64824245304187, "Scleroderma ": 10.63797234053519, "Sebaceous hyperplasia ": 48.97799942767748, "Secondary immunodeficiency ": 14.867153340335117, "Sepsis ": 4.003162685174839, "Septic embolus ": 7.197126617589531, "Septic shock ": 4.027269160293017, "Serum ferritin decreased ": 2.918959635759406, "Serum ferritin increased ": 6.538480860612826, "Skin atrophy ": 5.612532335146753, "Skin cancer ": 3.401106055511613, "Skin graft ": 17.9793872311801, "Skin hyperpigmentation ": 4.061092736016876, "Skin infection ": 4.12829917775097, "Skin injury ": 3.912370812095685, "Skin lesion ": 6.12849593283056, "Skin mass ": 10.966927843030064, "Skin necrosis ": 4.20122392047092, "Skin neoplasm excision ": 41.583784877478905, "Skin papilloma ": 7.077568314885081, "Skin plaque ": 11.013931144418216, "Skin ulcer ": 3.51591796035077, "Small for dates baby ": 6.89033277485059, "Smooth muscle cell neoplasm ": 138.06063727027387, "Soft tissue infection ": 8.468403573382417, "Splenectomy ": 4.200036732450712, "Splenic abscess ": 11.400612544129594, "Splenomegaly ": 4.990282906307159, "Squamous cell carcinoma ": 17.027931354295355, "Squamous cell carcinoma of skin ": 13.3252864784407, "Squamous cell carcinoma of the oral cavity ": 15.540744090947078, "Squamous cell carcinoma of the tongue ": 14.176702104609326, "Staphylococcal bacteraemia ": 6.536825229733476, "Staphylococcal infection ": 5.188843893456624, "Staphylococcal sepsis ": 6.235923952087454, "Stem cell transplant ": 12.310502992083835, "Stenotrophomonas infection ": 3.41461728012077, "Steroid diabetes ": 19.856322437971297, "Still's disease ": 6.344682318531322, "Streptococcal infection ": 4.516795844731306, "Streptococcal sepsis ": 4.707114622703459, "Subcutaneous abscess ": 3.410559908613433, "Sweat gland tumour ": 32.97253230584527, "Symptom recurrence ": 2.9553198714604143, "Systemic candida ": 7.609906660909628, "Systemic mycosis ": 10.44367546239378, "T-cell lymphoma ": 15.05023861167756, "Therapeutic product effect variable ": 4.03073006221037, "Therapeutic response decreased ": 4.000878507081898, "Therapy non-responder ": 3.615980035467321, "Thrombotic microangiopathy ": 32.49491132786436, "Thrombotic thrombocytopenic purpura ": 8.255537601194238, "Thyroid cancer metastatic ": 20.150005591740904, "Thyroidectomy ": 7.759749728517889, "Tongue ulceration ": 5.566217015564675, "Toxic encephalopathy ": 10.74354189057058, "Toxoplasmosis ": 16.46679768892643, "Transitional cell carcinoma ": 23.565271641428645, "Transplant dysfunction ": 22.76523346631521, "Transplant failure ": 20.50265647936352, "Transplant rejection ": 28.385830549513955, "Treatment failure ": 3.721941170611354, "Tuberculosis ": 4.488949391673467, "Tubulointerstitial nephritis ": 2.126574854698262, "Ulcer ": 4.371180005063804, "Ureteric stenosis ": 14.213455252192364, "Urinary occult blood positive ": 6.6964134246138, "Urinary tract infection bacterial ": 4.393551872612246, "Urinary tract obstruction ": 2.709496112152312, "Urine output decreased ": 3.2825942346689785, "VIth nerve paralysis ": 2.0273823482730573, "Varicella zoster virus infection ": 19.023282950213, "Vasogenic cerebral oedema ": 9.412007363956626, "Venoocclusive disease ": 10.366313850738765, "Venoocclusive liver disease ": 5.527681596705299, "Viraemia ": 4.528090599267239, "Viral haemorrhagic cystitis ": 51.13065306067522, "Viral infection ": 3.112165841892755, "Viral test positive ": 38.273802464270375, "Visceral leishmaniasis ": 35.85207887738773, "West Nile viral infection ": 40.44515392850197, "Wound dehiscence ": 3.423193442333331} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/269.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/269.json new file mode 100644 index 00000000000..98199bcc3dd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/269.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 5.785850433581323, "Adenovirus infection ": 178.91709454538486, "Blood creatinine increased ": 5.193897657878051, "Cytomegalovirus colitis ": 162.29863038383192, "Cytomegalovirus infection ": 41.440928314154455, "Cytomegalovirus infection reactivation ": 66.90277757766741, "Disease progression ": 2.623364475754772, "Drug ineffective ": 4.648242467684529, "Drug ineffective for unapproved indication ": 66.20740585584294, "Drug resistance ": 66.19412812334754, "Graft versus host disease in gastrointestinal tract ": 145.9283893197127, "Haematuria ": 4.976482507869688, "Hemiparesis ": 11.18727847729707, "Multiple-drug resistance ": 60.847392246304615, "Myelosuppression ": 4.7153669730625785, "Nephropathy toxic ": 105.4011116265018, "Neutropenia ": 2.1392633581911373, "Off label use ": 8.175209875911749, "Pancytopenia ": 8.245672673576786, "Pathogen resistance ": 29.723942328537767, "Polyomavirus-associated nephropathy ": 175.93598661295954, "Product use in unapproved indication ": 4.559843719411307, "Product use issue ": 7.898429186621002, "Progressive multifocal leukoencephalopathy ": 88.93765803221706, "Renal failure ": 2.290129625039424, "Renal impairment ": 14.528366705436037, "Respiratory failure ": 7.203238343053603, "Uveitis ": 50.39468728080397} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/27.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/27.json new file mode 100644 index 00000000000..ebb26901e8c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/27.json @@ -0,0 +1 @@ +{"Abdominal distension ": 3.6878005562341896, "Aneurysm ": 14.896472493686606, "Angina pectoris ": 5.8131658178941805, "Ascites ": 8.199063021325125, "Atelectasis ": 9.607014183201295, "Bladder neoplasm ": 214.99198798090544, "Blood immunoglobulin G increased ": 54.19663242197809, "Blood pressure abnormal ": 4.480595491442218, "Blood pressure decreased ": 3.240378589188541, "Blood pressure diastolic decreased ": 16.461796133706606, "Blood pressure systolic decreased ": 18.167031387000517, "Brain natriuretic peptide increased ": 35.71120497221266, "Bronchiectasis ": 7.228203542577359, "Cachexia ": 14.178485024584898, "Cardiac cirrhosis ": 466.59213295219536, "Cardiac failure ": 5.704150332788748, "Cardiac failure congestive ": 2.2875743704171136, "Cardiomegaly ": 5.1029667003308985, "Catheter site erythema ": 31.09215039085773, "Catheter site infection ": 23.725707624537367, "Catheter site pain ": 58.61882840648245, "Catheter site swelling ": 105.13386574166655, "Central venous catheterisation ": 25.697394403942678, "Cholelithiasis ": 2.6940427654210564, "Colitis ": 2.3153162566123444, "Complication associated with device ": 19.1108755301152, "Concomitant disease aggravated ": 10.458245977333153, "Delirium ": 5.184076086513179, "Device dislocation ": 23.1153981589487, "Device related infection ": 16.910098237378843, "Drug hypersensitivity ": 2.5610156637265917, "Duodenitis ": 24.60719711684903, "Dyspnoea exertional ": 7.401277973368491, "Dysstasia ": 2.4255694829677807, "Eosinophil count increased ": 4.262994294792495, "Eosinophilic oesophagitis ": 54.69795916037025, "Eosinophilic pneumonia ": 10.657785189773763, "Episcleritis ": 63.65494520700914, "Epistaxis ": 2.460733512122954, "Exercise tolerance decreased ": 4.6828264657273495, "Fall ": 2.7224344957079696, "Feeling abnormal ": 2.024008910818581, "Fluid retention ": 10.58654439901657, "Flushing ": 5.008542459656376, "Focal nodular hyperplasia ": 119.50748750356352, "Gamma-glutamyltransferase ": 212.78407609137832, "Gastrointestinal pain ": 4.7052299480691335, "Gastrointestinal wall thickening ": 60.44190481972753, "Haematemesis ": 2.932943338279294, "Haematocrit decreased ": 2.7382750792997625, "Haemoptysis ": 6.78110142447869, "Hepatic cirrhosis ": 7.033824432351459, "Hiccups ": 8.123789971034313, "Hospitalisation ": 6.2916768251943065, "Hot flush ": 2.624695088920644, "Hyperlipidaemia ": 4.939578954714165, "Hyperplasia of thymic epithelium ": 3312.9141942980823, "Hypersplenism ": 136.82930560037616, "Hypervolaemia ": 21.72081284231022, "Hypotension ": 2.422629678754842, "Hypovolaemia ": 10.658654492853346, "Hypoxia ": 6.086202415632863, "Interstitial lung disease ": 2.3807064037286896, "Iron deficiency anaemia ": 11.765056782075728, "Left ventricular failure ": 14.08996904100706, "Lipase increased ": 4.9118258206569845, "Liver disorder ": 3.237375237492586, "Localised infection ": 3.919718180451196, "Mallory-Weiss syndrome ": 62.22821080783974, "Mediastinal disorder ": 206.16236740389, "Mental status changes ": 2.539406521659177, "Nasal congestion ": 4.0079430509532, "Occult blood positive ": 22.21482856195279, "Oedema ": 4.344012397501819, "Oedema peripheral ": 2.731984846024386, "Overlap syndrome ": 169.2042777497253, "Oxygen saturation decreased ": 14.282584438429122, "Pain in jaw ": 22.686402456831495, "Pericardial effusion ": 6.914063135777443, "Peripheral swelling ": 3.807379056808041, "Pharyngeal oedema ": 5.8371633722833005, "Platelet count decreased ": 3.2246804373193183, "Platelet transfusion ": 63.65494520700914, "Pneumonia bacterial ": 9.63258671527971, "Portal fibrosis ": 493.2699308308524, "Portal hypertensive gastropathy ": 190.1001047735297, "Portal tract inflammation ": 435.214280130478, "Pulmonary alveolar haemorrhage ": 7.579080276744194, "Pulmonary arterial hypertension ": 34.03274727586867, "Pulmonary congestion ": 6.701267320435047, "Pulmonary hypertension ": 17.367461238321393, "Pulmonary oedema ": 8.875696350087567, "Renal disorder ": 2.2618408933462346, "Respiratory distress ": 2.0510171629656075, "Respiratory failure ": 2.3920959822605607, "Respiratory syncytial virus infection ": 24.41211866780808, "Retroperitoneal lymphadenopathy ": 103.74743064531977, "Right ventricular failure ": 31.74211611495988, "Scleroderma ": 42.51443995325182, "Serum ferritin decreased ": 30.863988873807475, "Splenomegaly ": 5.445091695802707, "Sputum retention ": 49.06237616204141, "Syncope ": 2.654082870601928, "Systemic scleroderma ": 81.24768652958652, "Transfusion ": 5.3137371965168825, "Troponin increased ": 6.494352890782109, "Varices oesophageal ": 21.885270361976197, "Vascular device infection ": 40.55112942673605} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/270.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/270.json new file mode 100644 index 00000000000..674c47f55e8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/270.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 5.403765303250289, "Abdominal adhesions ": 7.966332062231188, "Abdominal operation ": 5.194013025161884, "Abortion ": 2.410748623436002, "Abortion missed ": 2.2379192954486182, "Abortion spontaneous ": 2.6893184239613017, "Abscess ": 5.650877740085182, "Abscess intestinal ": 10.632784878283328, "Adverse drug reaction ": 3.356006351569542, "Adverse event ": 2.404089659482425, "Alopecia ": 2.5768761062588466, "Anal abscess ": 4.856043592079399, "Anal fistula ": 7.458681341348496, "Ankle operation ": 4.935553140089498, "Ankylosing spondylitis ": 77.07517434305815, "Anti-cyclic citrullinated peptide antibody ": 4.464105819633202, "Anti-cyclic citrullinated peptide antibody positive ": 4.017628138355303, "Arthritis ": 2.0671371760664337, "Arthritis bacterial ": 3.516786611990874, "Arthritis infective ": 3.437643931863468, "Arthrodesis ": 14.20421949429828, "Arthropathy ": 4.305032573210535, "Axial spondyloarthritis ": 68.66584521638245, "Back injury ": 2.121292440533906, "Basal cell carcinoma ": 2.1734574986539923, "Blister ": 7.965048363957997, "Blood pressure diastolic abnormal ": 3.4934455283471904, "Blood pressure diastolic increased ": 2.2017891762489423, "Bone erosion ": 2.39266632837647, "Breech presentation ": 6.121922775596226, "Bronchitis ": 2.4855468498444586, "Butterfly rash ": 4.213728663047349, "C-reactive protein abnormal ": 4.372986392654715, "C-reactive protein decreased ": 6.778591043839805, "Caesarean section ": 9.275905535585336, "Carpal tunnel syndrome ": 2.580782422396769, "Cellulitis ": 2.0991154964834227, "Clostridium difficile infection ": 3.002585580195356, "Coeliac disease ": 2.611479313126323, "Colectomy ": 3.3412561377999723, "Colitis microscopic ": 2.4391187651229056, "Colostomy ": 7.060240194721985, "Confusional state ": 2.7868644743756663, "Contraindicated product administered ": 9.139654051733412, "Contraindication to medical treatment ": 8.904888839553843, "Contusion ": 3.856073233314604, "Crohn's disease ": 27.157010758511703, "Croup infectious ": 8.167740694539107, "Cutaneous T-cell lymphoma ": 4.556434720007007, "Dactylitis ": 4.664513403590672, "Demyelinating polyneuropathy ": 2.549368610741219, "Demyelination ": 2.281851597732297, "Dermatitis psoriasiform ": 5.9649045740410855, "Device issue ": 6.348631306612947, "Diabetic eye disease ": 10.137098243849817, "Disseminated tuberculosis ": 6.945541698596145, "Diverticular perforation ": 4.433828401628127, "Drug hypersensitivity ": 2.966083482676343, "Drug ineffective ": 4.323004262379306, "Drug intolerance ": 5.01332174475362, "Drug specific antibody present ": 5.190419002760764, "Duodenal ulcer perforation ": 4.919933726969172, "Ear infection ": 2.275784953666424, "Ear pain ": 3.5548786332912696, "Enteritis infectious ": 3.17329169488174, "Enthesopathy ": 4.328978148542721, "Exposure to SARS-CoV-2 ": 6.634374531411826, "Exposure via breast milk ": 5.601344619762495, "Eye infection ": 2.0051793342526394, "Facet joint syndrome ": 3.2547225752119027, "Fear of injection ": 4.089456804164127, "Fibromyalgia ": 2.2966668644952866, "Fine motor skill dysfunction ": 4.2250061033487, "Fistula ": 13.356956916665265, "Folliculitis ": 30.64772172568333, "Foot operation ": 3.3507898573249024, "Fungal infection ": 3.254772315692148, "Gallbladder operation ": 2.899607146638193, "Gastric infection ": 3.1284584018076647, "Gastroenteritis viral ": 2.378696337916613, "Gastrointestinal disorder ": 8.255972126511143, "Gastrointestinal infection ": 2.041999074780153, "Gastrointestinal inflammation ": 2.249389789070774, "Gestational diabetes ": 5.495812119432511, "Gestational hypertension ": 2.654718599477569, "Glossodynia ": 3.538847448953307, "Grip strength decreased ": 5.76231782224933, "Groin abscess ": 5.151651163105396, "Guttate psoriasis ": 3.6914724927390754, "Hand deformity ": 4.25835228837303, "Helicobacter infection ": 4.9750139638081565, "Hepatic enzyme increased ": 2.1675295215674093, "Hernia ": 2.609094590820507, "Hernia repair ": 3.8876252647257368, "Hidradenitis ": 9.4000427911574, "Hip arthroplasty ": 3.717593617854537, "Hip surgery ": 3.1395880281686988, "Hospitalisation ": 2.871525901494822, "Hypersensitivity ": 4.424120274967708, "Hysterectomy ": 2.631512360634101, "Ileal stenosis ": 11.303376972032016, "Ileostomy ": 10.683392951223796, "Ill-defined disorder ": 15.222508493103383, "Immunosuppression ": 3.0287213766976744, "Impaired healing ": 23.846800106694268, "Inability to afford medication ": 10.5101716106299, "Infection ": 8.48455375233668, "Inflammation ": 2.285354297074665, "Inflammatory bowel disease ": 3.712675855536364, "Inflammatory marker increased ": 4.701261183651728, "Infusion related reaction ": 2.386729055641581, "Injection site bruising ": 2.539293763525705, "Injection site discolouration ": 17.048523272022646, "Injection site haemorrhage ": 2.11013919827168, "Injection site irritation ": 3.786251237328044, "Injection site rash ": 2.6908221422303, "Injection site urticaria ": 3.251129943625961, "Injection site vesicles ": 2.1429518965813568, "Insurance issue ": 41.84917315920302, "Intentional dose omission ": 12.84291335166854, "Intentional product use issue ": 2.0783979748450414, "Intercepted product prescribing error ": 6.133378396493077, "Intervertebral discitis ": 2.368664413605335, "Intestinal obstruction ": 3.227984517342913, "Intestinal resection ": 15.434734262646735, "Intestinal stenosis ": 19.61296177341615, "Intestinal ulcer ": 3.956202933851017, "Intra-abdominal fluid collection ": 2.8247976204507483, "Iron deficiency anaemia ": 2.182474194863138, "Irritable bowel syndrome ": 29.22903886591617, "Joint arthroplasty ": 10.13906413396668, "Joint effusion ": 3.5393969472565843, "Joint injury ": 2.687809998281132, "Joint lock ": 2.5450388060309463, "Joint stiffness ": 2.823734743517155, "Joint swelling ": 10.015853476221784, "Joint warmth ": 2.2675807696834, "Juvenile idiopathic arthritis ": 11.807830585579676, "Kidney infection ": 2.5763847489257863, "Knee arthroplasty ": 4.018604794216641, "Knee operation ": 4.767332042148009, "Large intestinal stenosis ": 11.227975899318842, "Latent tuberculosis ": 9.26262196935666, "Ligament rupture ": 5.20665111649671, "Limb operation ": 2.737561857072276, "Lip ulceration ": 10.041032503182407, "Liver function test increased ": 2.989521300876958, "Loss of personal independence in daily activities ": 3.032854617310936, "Loss of therapeutic response ": 3.099942773167552, "Low birth weight baby ": 5.001820523592239, "Lower respiratory tract infection ": 20.26161822074207, "Lung adenocarcinoma ": 2.7856866297565377, "Lupus-like syndrome ": 9.2787729478573, "Lymph node tuberculosis ": 7.379343097928687, "Lymphoproliferative disorder ": 3.46824380424903, "Maternal exposure before pregnancy ": 55.73641010039992, "Maternal exposure during breast feeding ": 13.108665570439214, "Maternal exposure during pregnancy ": 8.501416567092992, "Meningitis ": 2.308196561470091, "Menopause ": 6.383010905401272, "Mouth ulceration ": 2.040270593375836, "Muscle injury ": 53.28368191580831, "Muscle spasticity ": 3.2656670557140512, "Mycobacterium tuberculosis complex test positive ": 13.202259101927009, "Nail disorder ": 7.334374446264041, "Nail operation ": 20.74366818411284, "Nail psoriasis ": 12.58621256834057, "Nasopharyngitis ": 6.924987708275627, "Neck mass ": 2.8649195576462816, "Neck surgery ": 5.018470107156419, "Needle issue ": 5.281202013630307, "Non-alcoholic fatty liver ": 8.973140985549891, "Onychomadesis ": 7.63890452214577, "Onychomycosis ": 12.499882906579542, "Optic neuritis ": 2.067653581497214, "Oral infection ": 4.213934720723039, "Ovarian disorder ": 11.159622841328934, "Palmoplantar pustulosis ": 17.161376005049508, "Papilloma viral infection ": 2.1577202957596198, "Paradoxical psoriasis ": 26.15502052521021, "Pemphigus ": 3.6586710550476425, "Peripheral swelling ": 4.44986124933645, "Peripheral venous disease ": 2.908719501866156, "Perirectal abscess ": 10.018949033417709, "Peritoneal tuberculosis ": 13.94469109812356, "Pertussis ": 5.7391930925206855, "Pharyngitis streptococcal ": 5.9039332459305065, "Pneumonia legionella ": 6.976463880571726, "Polyarthritis ": 2.578406131922832, "Post procedural infection ": 2.994667647337176, "Pregnancy ": 2.262536937481636, "Pregnancy on contraceptive ": 4.9574817533598505, "Premature baby ": 2.2504761444678416, "Premature delivery ": 4.610093554704861, "Premature rupture of membranes ": 2.7935991501198085, "Procedural pain ": 2.865014836702534, "Proctalgia ": 2.4567204029914484, "Product availability issue ": 8.024197737829825, "Product distribution issue ": 13.240319325083757, "Product dose omission in error ": 2.857514498487939, "Product dose omission issue ": 3.365618526074924, "Psoriasis ": 10.59522853520784, "Psoriatic arthropathy ": 15.422106312276972, "Pulmonary sarcoidosis ": 4.117240292312848, "Pulmonary tuberculosis ": 3.239577667191264, "Pustular psoriasis ": 6.639393706416398, "Quality of life decreased ": 2.4716785346551564, "Rectal abscess ": 18.384914281204043, "Red blood cell sedimentation rate abnormal ": 5.548832658261476, "Rheumatic fever ": 12.880976966082926, "Rheumatoid arthritis ": 19.28403753308313, "Rheumatoid factor negative ": 32.11747857238719, "Rheumatoid factor positive ": 3.0033879385232582, "SARS-CoV-2 test negative ": 5.488150365774672, "Sacroiliitis ": 7.847750960247351, "Sarcoidosis ": 2.447485610845775, "Serum sickness ": 4.068640380530852, "Shoulder arthroplasty ": 2.951268166059623, "Shoulder operation ": 3.1327384456900718, "Sinus disorder ": 2.307452977914312, "Sinusitis ": 15.466137674384894, "Sjogren's syndrome ": 2.0358165845386416, "Skin cancer ": 2.6504238543620406, "Skin infection ": 2.173299914758889, "Sleep disorder ": 2.797161979512248, "Sleep disorder due to general medical condition, insomnia type ": 46.33495291967442, "Small for dates baby ": 3.0175842901332124, "Small intestinal obstruction ": 5.139344961903111, "Spinal fusion surgery ": 2.447243175760893, "Spinal operation ": 3.3136999440473653, "Spinal stenosis ": 4.36921179170128, "Spondylitis ": 2.085194695992464, "Staphylococcal infection ": 2.5447318845239675, "Stomatitis ": 9.703749423925144, "Streptococcal infection ": 2.172062824306629, "Stress ": 2.6307595387224576, "Stress fracture ": 6.888361547584975, "Subcutaneous abscess ": 4.195888796306615, "Surgery ": 10.577358921951962, "Swelling ": 5.527716011154509, "Swollen joint count increased ": 5.767018948790028, "Synovitis ": 13.66204840752829, "Syringe issue ": 4.412264864128447, "Systemic lupus erythematosus ": 3.454064013744959, "Tendon pain ": 3.0778554884587708, "Therapeutic product effect decreased ": 19.04006000025908, "Therapeutic response shortened ": 13.943648782602017, "Therapy cessation ": 2.5274050588327457, "Therapy interrupted ": 28.252553189264148, "Tooth abscess ": 2.5644337830174586, "Tooth infection ": 2.502074311756609, "Transaminases abnormal ": 6.795047946597921, "Treatment failure ": 5.491201583971994, "Tuberculin test positive ": 16.84121031811707, "Tuberculosis ": 6.662518110693955, "Twin pregnancy ": 17.944659623278998, "Type 2 diabetes mellitus ": 2.7173077331078144, "Upper respiratory tract infection ": 2.692425945512653, "Urinary tract infection ": 2.708509494914809, "Uveitis ": 8.993196914260153, "Weight increased ": 4.488746646846282, "Wheelchair user ": 2.246067767444204, "X-ray abnormal ": 20.774200872363217} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/271.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/271.json new file mode 100644 index 00000000000..bccd6286fd6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/271.json @@ -0,0 +1 @@ +{"Blood parathyroid hormone increased ": 103.91006500180652, "Calciphylaxis ": 300.190411977793, "Cholelithiasis ": 8.787950398606334, "Death ": 13.156405955651817, "Diarrhoea ": 2.113753331138804, "Disease progression ": 2.54674751617962, "Drug ineffective ": 2.1013344625657924, "Exposure during pregnancy ": 2.477879859003009, "Foetal exposure during pregnancy ": 9.842911919899434, "Gastrointestinal disorder ": 4.766259927610637, "Hypercalcaemia ": 74.16233246502723, "Hypocalcaemia ": 116.03859378297116, "Hypomagnesaemia ": 29.49062506154964, "Low birth weight baby ": 32.968006986081015, "Maternal exposure during pregnancy ": 6.86188301810864, "Normal newborn ": 46.40508512384153, "Premature baby ": 26.46755019392775, "Premature delivery ": 20.12054408455916, "Rash pruritic ": 3.009111845856291, "Rectal haemorrhage ": 4.418707178753816, "Sepsis ": 3.071000454438414, "Urinary tract infection ": 2.260921714591871, "Vomiting ": 2.500601527984508} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/272.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/272.json new file mode 100644 index 00000000000..a5360423833 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/272.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 4.352654143550742, "Angioedema ": 7.445373446651264, "Complication associated with device ": 38.655144476502414, "Device related infection ": 19.926846416457927, "Exposure during pregnancy ": 7.8920769342315396, "Hereditary angioedema ": 786.3584686317851, "Hospitalisation ": 9.845387999048516, "Inappropriate schedule of product administration ": 26.81581071894328, "Incorrect drug administration rate ": 62.40536052352757, "Infusion related reaction ": 9.204765678981673, "Laryngeal oedema ": 13.42755452938998, "Off label use ": 2.2990442975144783, "Poor venous access ": 172.09378108364504, "Prescribed overdose ": 24.101428144326384, "Product dose omission issue ": 8.953254952537142, "Product use in unapproved indication ": 5.038553440713878, "Sepsis ": 2.13093587934743, "Sinusitis ": 2.282089771147339, "Staphylococcal infection ": 6.843836990133736, "Stress ": 6.568027563436781, "Therapeutic product effect decreased ": 3.2720390997967184, "Therapy change ": 677.5994164670113, "Thrombosis ": 2.483107490169305, "Unevaluable event ": 6.106478130705123, "Vascular device infection ": 155.2045432124882} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/273.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/273.json new file mode 100644 index 00000000000..3556e2873ef --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/273.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 11.465604490786784, "Aggression ": 5.947004397993815, "Agitation ": 7.1478951115526215, "Agranulocytosis ": 4.245743534894539, "Akathisia ": 9.333845112202145, "Confusional state ": 2.739433826776972, "Depressed mood ": 2.291865086084391, "Disorientation ": 3.2616248585858125, "Disturbance in attention ": 2.272031838453262, "Dry mouth ": 2.585894674187002, "Epilepsy ": 3.9065289112923858, "Flatulence ": 4.70707468977219, "Hallucination ": 2.4172366783909487, "Hepatic cytolysis ": 4.117291280695244, "Hyperthyroidism ": 3.9692516583275887, "Hyponatraemia ": 2.610295710324878, "Incorrect product administration duration ": 7.978143020267403, "Initial insomnia ": 12.786826748189362, "Insomnia ": 3.0486810359517484, "Intentional overdose ": 12.446035773319412, "Intentional self-injury ": 30.720896867071737, "Irritability ": 3.2313247085520844, "Labelled drug-drug interaction medication error ": 14.852121223881658, "Middle insomnia ": 21.07027534721172, "Mixed liver injury ": 34.87244284217698, "Nervousness ": 2.648308451035515, "Night sweats ": 3.661918913374096, "Nightmare ": 16.279928442093993, "Nocturia ": 11.33478305423614, "Off label use ": 2.350284432991073, "Overdose ": 4.953701314060728, "Palpitations ": 2.4883188312117897, "Poor quality sleep ": 10.39316768658454, "Prescribed overdose ": 11.727236751747808, "Product administered to patient of inappropriate age ": 237.60224187662067, "Product use issue ": 3.6287814862931618, "Purpura ": 10.53706242415973, "Rash macular ": 3.895195151923355, "Rash maculo-papular ": 5.624580362637078, "Restless legs syndrome ": 10.03443665016759, "Restlessness ": 8.214943239839949, "Sedation ": 5.800682164551576, "Sleep disorder ": 3.328391424298381, "Somnolence ": 7.877651380703721, "Suicide attempt ": 4.480373400572181, "Vision blurred ": 2.474553016854664, "Wrong technique in product usage process ": 4.568922209900865} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/274.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/274.json new file mode 100644 index 00000000000..049eb06f11e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/274.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 27.049446793580245, "Acute myeloid leukaemia recurrent ": 44.58264613234225, "Agranulocytosis ": 2.2373629814570224, "Anaemia ": 3.190123008504732, "Aspergillus infection ": 23.802717880151977, "Bronchopulmonary aspergillosis ": 25.96114587225858, "Clostridium bacteraemia ": 1957.8827723725296, "Clostridium difficile infection ": 6.070420664000085, "Cytopenia ": 6.426857346856362, "Demodicidosis ": 2700.08201525175, "Disease progression ": 3.2888622444537363, "Disease recurrence ": 6.596649099617163, "Enterococcal infection ": 53.53836207405568, "Febrile neutropenia ": 22.688508091551977, "Haematotoxicity ": 13.235147303194593, "Hairy cell leukaemia ": 1196.8137419501625, "Hairy cell leukaemia recurrent ": 4039.7874875360335, "Hyperbilirubinaemia ": 5.348457993814543, "Hypoalbuminaemia ": 16.954039956950083, "Incorrect dose administered ": 3.8544604396674607, "Infection ": 2.479593854866181, "Langerhans' cell histiocytosis ": 354.6834325581087, "Leukopenia ": 4.44222378542556, "Lymphocyte count decreased ": 27.903304097236344, "Lymphopenia ": 68.82968895258274, "Multiple organ dysfunction syndrome ": 6.7989066677518455, "Multiple sclerosis ": 8.726772442789567, "Multiple sclerosis relapse ": 15.519533093867665, "Myelodysplastic syndrome ": 62.9200925648239, "Myelosuppression ": 6.658471251034292, "Neoplasm progression ": 2.043606209396206, "Neutropenia ": 8.580285828909735, "Neutropenic colitis ": 98.72312854272454, "Neutrophil count decreased ": 2.69237081794614, "Off label use ": 4.640900072651839, "Pancytopenia ": 38.17989303271306, "Pneumonia ": 2.0953979966261205, "Product use in unapproved indication ": 12.26969091218833, "Rash maculo-papular ": 8.128794293862292, "Respiratory failure ": 3.9887900386548223, "Sepsis ": 6.033897755790791, "Septic shock ": 3.044982004551825, "Therapeutic product effect incomplete ": 3.4530407261775795, "Thrombocytopenia ": 6.136233854978364, "Toxic skin eruption ": 4.775728324497839, "White blood cell count decreased ": 2.105249887368532} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/275.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/275.json new file mode 100644 index 00000000000..9e17667a4c1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/275.json @@ -0,0 +1 @@ +{"Disease recurrence ": 25.15581425248938, "Drug hypersensitivity ": 18.63975385307859, "Drug ineffective ": 2.239465354046361, "Joint range of motion decreased ": 43.28735853395841, "Lyme disease ": 251.9226149215846, "Pneumonia ": 6.813956239750337} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/276.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/276.json new file mode 100644 index 00000000000..8bfbd001281 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/276.json @@ -0,0 +1 @@ +{"Acute lymphocytic leukaemia ": 81.50811653228288, "Acute myeloid leukaemia ": 31.76048968967356, "Acute myeloid leukaemia recurrent ": 66.45208138161259, "Anaemia ": 2.7672194994595105, "Aspergillus infection ": 31.13863881843494, "Bone marrow failure ": 45.64731766443301, "Capillary leak syndrome ": 113.56356207144614, "Cellulitis ": 7.785494328399304, "Colitis ": 5.1551841796299085, "Disease progression ": 6.142890052573388, "Drug resistance ": 5.220164781447125, "Febrile neutropenia ": 21.71906540082924, "Fusarium infection ": 322.4011120110772, "Hepatotoxicity ": 7.595775336717903, "Hyperbilirubinaemia ": 12.53120197398825, "Infection ": 3.0705472904990945, "Klebsiella sepsis ": 136.05771328017923, "Leukaemia recurrent ": 77.08779789168332, "Lymphopenia ": 23.736809040512, "Malignant neoplasm progression ": 2.6297882588930475, "Mucosal inflammation ": 10.625306983762046, "Multiple organ dysfunction syndrome ": 18.03431775606538, "Neoplasm progression ": 3.410873043513219, "Neutropenia ": 6.956907427150775, "Off label use ": 2.5813209870849096, "Palmar-plantar erythrodysaesthesia syndrome ": 9.674008355036984, "Pancytopenia ": 8.462996114289497, "Pneumonia ": 2.3814190786406546, "Product use in unapproved indication ": 2.016291808389141, "Product use issue ": 4.355088636534059, "Pulmonary mass ": 15.478337669749374, "Rash maculo-papular ": 3.293765757246716, "Respiratory failure ": 5.014984057171459, "Sepsis ": 7.408162315464749, "Septic shock ": 12.769989342297688, "Sinusitis ": 5.567235863554169, "Stomatitis ": 2.4413089805958617, "Swelling face ": 2.897593172655154, "Therapy non-responder ": 9.934147011283091, "Thrombocytopenia ": 4.07010763867743, "Transaminases increased ": 3.7368416377832654} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/277.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/277.json new file mode 100644 index 00000000000..6d38d4eaf67 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/277.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.158310917430628, "Abdominal pain upper ": 2.075140331279083, "Abdominal tenderness ": 5.140017334644753, "Abdominal wall haematoma ": 10.114151823966848, "Acquired haemophilia ": 9.340626889969094, "Activated partial thromboplastin time prolonged ": 3.4532026165654037, "Acute coronary syndrome ": 4.998620401909475, "Acute myocardial infarction ": 7.865502278055255, "Akinesia ": 2.2360412093580933, "Allergic cough ": 14.725311616352537, "Amaurosis ": 15.19109012098996, "Anaemia ": 2.735770622474474, "Anaemia macrocytic ": 2.3477833114373263, "Anal haemorrhage ": 3.8157259600014415, "Angina pectoris ": 3.493836686260948, "Angina unstable ": 4.950995703904378, "Angiodysplasia ": 12.688749454675072, "Angiopathy ": 2.545312035007541, "Angioplasty ": 4.130656930717373, "Anticoagulation drug level above therapeutic ": 2.086849182284414, "Aortic aneurysm ": 2.3641183508725288, "Aortic arteriosclerosis ": 2.5021840563469584, "Aortic stenosis ": 3.0412668697915946, "Aortic thrombosis ": 6.214309686572341, "Aortic valve incompetence ": 3.819298092502562, "Aortic valve stenosis ": 4.821591301420276, "Aphasia ": 2.054712868220362, "Arterial haemorrhage ": 20.6059909811743, "Arterial injury ": 9.55799862144343, "Arterial rupture ": 10.211024499536814, "Arterial thrombosis ": 3.006575658523409, "Arteriosclerosis coronary artery ": 2.121391044178571, "Atheroembolism ": 38.85042299652065, "Atrial thrombosis ": 3.0775439563132663, "Basal ganglia haemorrhage ": 7.166514415946006, "Behaviour disorder ": 2.3996863199813623, "Bladder disorder ": 2.5365319088348848, "Bleeding time prolonged ": 12.397029740644603, "Bleeding varicose vein ": 7.974073917778734, "Blood albumin decreased ": 2.1995736055801647, "Blood aldosterone decreased ": 54.23659967521549, "Blood cholesterol ": 35.45634961220281, "Blood fibrinogen increased ": 3.199922434612168, "Blood iron decreased ": 3.9772751489881975, "Blood loss anaemia ": 42.42772001214277, "Blood osmolarity increased ": 16.92456982373375, "Blood pressure diastolic decreased ": 5.759557969354538, "Blood pressure systolic abnormal ": 7.441582571895414, "Blood pressure systolic decreased ": 2.1612754406515995, "Body mass index decreased ": 10.420439882071758, "Brain herniation ": 10.450232712137264, "Brain stem haemorrhage ": 15.619204457777888, "Bronchitis ": 2.985298901728321, "Bundle branch block left ": 2.7020030384458047, "Cardiac aneurysm ": 15.28714788047587, "Cardiac death ": 6.36854906882229, "Cardiac failure acute ": 3.048286172336096, "Cardiac failure chronic ": 3.482872869720398, "Cardiac fibrillation ": 2.555329929368152, "Cardiac tamponade ": 9.51010582894025, "Cardiac ventricular thrombosis ": 6.594604258241137, "Cardiogenic shock ": 2.3335780219453928, "Carotid arteriosclerosis ": 5.114031608264401, "Carotid artery occlusion ": 2.514811233509634, "Carotid artery stenosis ": 3.115325471763392, "Catheter site haematoma ": 27.212191085595364, "Catheter site haemorrhage ": 6.992388416708983, "Cerebellar haematoma ": 8.903028453938528, "Cerebellar haemorrhage ": 14.629560660219465, "Cerebral artery embolism ": 5.47832433615844, "Cerebral haematoma ": 15.9748591714302, "Cerebral haemorrhage ": 8.637510762302227, "Cerebral infarction ": 3.183037869673301, "Cerebral mass effect ": 12.72186839647132, "Cerebral microhaemorrhage ": 12.5934869229776, "Cholecystitis acute ": 2.097446672951597, "Chronic gastritis ": 17.04574887142867, "Coagulation test abnormal ": 4.811073366313274, "Coagulation time prolonged ": 11.451774500120958, "Coagulopathy ": 4.430188697001353, "Colonic haematoma ": 45.76330366533475, "Coma scale abnormal ": 2.9098652366409574, "Compartment syndrome ": 2.112383925938182, "Conjunctival haemorrhage ": 10.014906575958348, "Conjunctival pallor ": 64.68798546849972, "Contraindicated product administered ": 2.2802936992207106, "Contraindicated product prescribed ": 4.03797702723031, "Contusion ": 2.465483121837764, "Coronary artery bypass ": 3.4960660241213137, "Coronary artery disease ": 3.9681945353950256, "Coronary artery dissection ": 10.746012386085818, "Coronary artery occlusion ": 5.421516357231493, "Coronary artery restenosis ": 11.349834853441555, "Coronary artery stenosis ": 8.224778238425733, "Coronary artery thrombosis ": 17.235388235048, "Cystitis ": 5.500564599054324, "Degenerative mitral valve disease ": 369.3459951479402, "Dermatitis exfoliative ": 2.50320878258883, "Device occlusion ": 6.1674818016265816, "Diarrhoea haemorrhagic ": 3.859514856832439, "Diastolic dysfunction ": 2.8967512327550278, "Discoloured vomit ": 11.3568209162791, "Diverticulum intestinal ": 2.226328070478785, "Diverticulum intestinal haemorrhagic ": 23.18386310420243, "Drug interaction ": 3.2665679442574227, "Drug resistance ": 3.827997398253055, "Drug-induced liver injury ": 2.684328374598619, "Duodenal ulcer ": 14.145456916298343, "Duodenal ulcer haemorrhage ": 21.64267972970896, "Duodenitis ": 10.954179234659096, "Dyspnoea at rest ": 3.450205573618499, "ECG signs of myocardial ischaemia ": 24.65973361642249, "Ear haemorrhage ": 2.8458389050122754, "Ecchymosis ": 14.287845017436704, "Ejection fraction decreased ": 2.8981634519498822, "Electrocardiogram Q wave abnormal ": 23.073940228132265, "Electrocardiogram ST segment depression ": 4.597917388514503, "Electrocardiogram ST segment elevation ": 4.074587902460815, "Embolic stroke ": 5.853511918684582, "Epigastric discomfort ": 6.030895634193687, "Epistaxis ": 6.042068347876902, "Erosive oesophagitis ": 3.279090839059202, "Eructation ": 2.8943102439115744, "Extradural haematoma ": 26.784113594487632, "Extravasation blood ": 7.332865957705076, "Eye haemorrhage ": 2.7575271147324703, "Faecaloma ": 2.1016806750942885, "Faeces discoloured ": 14.034428357217305, "Faeces hard ": 2.8722254461183514, "Fibromyalgia ": 4.020542991004923, "Fluid retention ": 4.099905228238516, "Gastric haemorrhage ": 14.538314558803004, "Gastric mucosal lesion ": 29.458280417869894, "Gastric occult blood positive ": 92.89624782817133, "Gastric polyps ": 3.484345687677149, "Gastric ulcer ": 10.656456292134433, "Gastric ulcer haemorrhage ": 14.20601063714873, "Gastritis ": 2.9372411127720413, "Gastritis erosive ": 17.864335142966205, "Gastritis haemorrhagic ": 6.033586441626283, "Gastrointestinal angiodysplasia ": 8.921760517344792, "Gastrointestinal erosion ": 9.094701559184733, "Gastrointestinal haemorrhage ": 21.18256151102046, "Gastrointestinal polyp haemorrhage ": 10.278543701339492, "Gastrointestinal ulcer ": 4.471895555675629, "Gastrointestinal ulcer haemorrhage ": 29.438597113229463, "Gastrointestinal vascular malformation haemorrhagic ": 13.663792869126898, "Genital haemorrhage ": 3.386717615947022, "Gingival bleeding ": 8.3446496005831, "Gouty arthritis ": 5.895164156482704, "Gynaecomastia ": 2.200967300385809, "Haemarthrosis ": 2.2725792155679425, "Haematemesis ": 26.56258282486024, "Haematochezia ": 13.645708397845585, "Haematocrit decreased ": 2.103426154553095, "Haematoma ": 6.404229353443926, "Haematoma muscle ": 11.336636315875763, "Haematuria ": 10.301576385550746, "Haemobilia ": 15.673936098548204, "Haemodynamic instability ": 4.745366518384548, "Haemoglobin abnormal ": 4.670267234407192, "Haemoglobin decreased ": 6.234886379317853, "Haemoperitoneum ": 4.929171367544738, "Haemoptysis ": 8.334232792604215, "Haemorrhage ": 6.083684213450085, "Haemorrhage intracranial ": 13.289600581470593, "Haemorrhage subcutaneous ": 29.29084204706705, "Haemorrhage urinary tract ": 15.200713485472326, "Haemorrhagic cerebral infarction ": 22.076405145247605, "Haemorrhagic diathesis ": 6.633822737918919, "Haemorrhagic disorder ": 2.9681909075899995, "Haemorrhagic erosive gastritis ": 19.70840956180619, "Haemorrhagic infarction ": 22.542772065178504, "Haemorrhagic stroke ": 5.261956464789226, "Haemorrhagic transformation stroke ": 21.22556176377692, "Haemorrhoidal haemorrhage ": 6.314302532514554, "Haemothorax ": 14.623208397234476, "Heart failure with reduced ejection fraction ": 8.198624856700048, "Heart sounds abnormal ": 6.198842025354285, "Helicobacter test positive ": 5.98689183606869, "Hemiparesis ": 3.952761704056571, "Hemiplegia ": 3.0858023232308294, "Hepatic cyst ": 2.239564526449165, "Hepatic enzyme abnormal ": 3.489933948304826, "Hepatojugular reflux ": 32.14990981262236, "Hernia ": 2.160702890925544, "Hydrocephalus ": 3.774310683076077, "Hyphaema ": 13.369445891243243, "Hypomagnesaemia ": 2.0345571342017026, "Hypoproteinaemia ": 2.0232260218516545, "Hypovolaemic shock ": 3.711692640599576, "Inadequate analgesia ": 2.095703131777292, "Incorrect dosage administered ": 2.9078052897758204, "Increased tendency to bruise ": 3.346996636336995, "Infective exacerbation of chronic obstructive airways disease ": 7.596002163034264, "Inferior vena cava dilatation ": 20.89760281240041, "Insulin autoimmune syndrome ": 41.55928355147467, "Intermittent claudication ": 4.1878062640327816, "Internal haemorrhage ": 2.707054022941178, "Intestinal haematoma ": 10.42984206444636, "Intestinal haemorrhage ": 7.588197071354648, "Intestinal ischaemia ": 2.246694967618632, "Intra-abdominal haematoma ": 4.639135301849243, "Intra-abdominal haemorrhage ": 6.322121133285243, "Intracranial haematoma ": 19.586023268805896, "Intraventricular haemorrhage ": 14.51566134545476, "Iron deficiency anaemia ": 4.456147188090807, "Ischaemia ": 2.2545682429866, "Ischaemic cardiomyopathy ": 3.988724709882757, "Ischaemic hepatitis ": 13.578741053825404, "Ischaemic stroke ": 2.480939968419201, "Joint noise ": 2.1055990792331785, "Jugular vein distension ": 10.43206311564773, "Kounis syndrome ": 3.8459194677099817, "Labelled drug-disease interaction medication error ": 9.291289701054849, "Labelled drug-drug interaction issue ": 158.2656764770822, "Labelled drug-drug interaction medication error ": 157.08693147264688, "Labile hypertension ": 11.96470698346977, "Large intestinal haemorrhage ": 6.715140177953983, "Large intestinal ulcer ": 2.2214656111340023, "Left ventricular dysfunction ": 4.395230166769288, "Left ventricular hypertrophy ": 2.5233553145116003, "Lip erosion ": 5.809397809441265, "Lip haemorrhage ": 6.9612232472192535, "Lower gastrointestinal haemorrhage ": 37.284092462076295, "Lung hyperinflation ": 5.733094397337681, "Lymphadenopathy mediastinal ": 3.067998196657192, "Lymphoedema ": 14.249488569813913, "Mallory-Weiss syndrome ": 10.865425450974785, "Mean cell haemoglobin decreased ": 6.658986189078273, "Mediastinal haematoma ": 53.67010567280488, "Medication error ": 2.0525608085852287, "Melaena ": 40.16938217847586, "Microcytic anaemia ": 3.553955417121922, "Minimal residual disease ": 9.27448047184934, "Mitral valve disease ": 3.0435752408174177, "Mitral valve incompetence ": 2.904069873189179, "Mouth haemorrhage ": 6.025420022427461, "Mucosal haemorrhage ": 9.850598780435396, "Muscle haemorrhage ": 5.12379450647086, "Myocardial infarction ": 2.435864937934077, "Myocardial ischaemia ": 2.6694494034922736, "Myocardial necrosis marker increased ": 6.676080168420926, "N-terminal prohormone brain natriuretic peptide increased ": 14.236723301531814, "Neutrophil percentage increased ": 4.184973554682112, "Nikolsky's sign ": 5.951958197405623, "Nipple swelling ": 29.11222027064911, "Non-small cell lung cancer recurrent ": 29.17608234903769, "Normocytic anaemia ": 4.2148065615427885, "Obstructive sleep apnoea syndrome ": 2.3871152939624887, "Occult blood ": 11.73133023751578, "Occult blood positive ": 45.37271107912906, "Oesophageal haemorrhage ": 7.986215871109961, "Oesophageal intramural haematoma ": 64.70018974451897, "Oesophageal pain ": 6.793475314256406, "Oesophageal spasm ": 20.317414140912863, "Oesophageal ulcer ": 4.118372943234711, "Oesophagitis ": 2.678482801731417, "Orthopnoea ": 5.545925999150536, "Pallor ": 2.539166176506703, "Paraplegia ": 5.954199184311182, "Peptic ulcer ": 5.363863610229037, "Peptic ulcer haemorrhage ": 24.48181441598375, "Percutaneous coronary intervention ": 14.56132232579404, "Pericardial haemorrhage ": 17.07358004808956, "Peripheral arterial occlusive disease ": 2.483426744165686, "Peripheral artery occlusion ": 2.3722351744245707, "Peripheral artery thrombosis ": 2.864715582791518, "Petechiae ": 3.818921652573308, "Pharyngeal disorder ": 2.3326561609602443, "Pharyngeal haematoma ": 36.49302472931458, "Pharyngeal haemorrhage ": 5.428654464416129, "Pituitary enlargement ": 19.083623760488734, "Pituitary tumour benign ": 4.303349556426392, "Platelet count increased ": 2.342417069614416, "Platelet disorder ": 2.004966686174166, "Polyarthritis ": 2.6529248914234174, "Post procedural haematoma ": 9.270539631213488, "Post procedural haemorrhage ": 13.04822598588826, "Potentiating drug interaction ": 4.426172754512345, "Prerenal failure ": 4.850860782404132, "Prescribed underdose ": 3.195652594005692, "Prescription drug used without a prescription ": 2.604691817051813, "Primary adrenal insufficiency ": 25.63798001918226, "Procedural haemorrhage ": 18.24911069287091, "Product administration error ": 4.830460958153646, "Product monitoring error ": 6.712555036788778, "Product prescribing issue ": 11.744262975471695, "Product substitution issue ": 3.3441673211103127, "Prognathism ": 24.912736912382098, "Prostatomegaly ": 8.28124846984374, "Prothrombin time prolonged ": 3.5260905952348103, "Pulmonary alveolar haemorrhage ": 7.845440911121792, "Pulmonary haematoma ": 45.76330366533475, "Pulmonary haemorrhage ": 8.600919746395673, "Puncture site haemorrhage ": 17.030212021236384, "Purpura ": 3.7683194500790975, "Putamen haemorrhage ": 10.724361031970002, "Quadriparesis ": 4.073651944482668, "Quadriplegia ": 3.2483733171611955, "Rales ": 4.227284391479579, "Reaction to excipient ": 3.678237880481062, "Rectal haemorrhage ": 5.51232751021054, "Rectal ulcer ": 4.181403101425805, "Rectal ulcer haemorrhage ": 13.970288994597087, "Regurgitation ": 3.09817105176537, "Renal haemorrhage ": 6.3585421998165375, "Respiratory rate increased ": 6.178410266384722, "Respiratory tract haemorrhage ": 28.571753214530126, "Retinal haemorrhage ": 3.5420136011383647, "Retroperitoneal haematoma ": 18.09341681949948, "Retroperitoneal haemorrhage ": 17.724427985785972, "Rhonchi ": 3.256334380081722, "Shock haemorrhagic ": 15.448649536824144, "Skin flap necrosis ": 241.16165023190663, "Skin haemorrhage ": 3.939928753270861, "Sleep apnoea syndrome ": 3.421456930786577, "Small intestinal haemorrhage ": 16.24375573160993, "Spinal cord compression ": 4.474111210145527, "Spinal cord haemorrhage ": 15.616090848216595, "Spinal epidural haematoma ": 83.51557605253906, "Spinal subarachnoid haemorrhage ": 101.41288873084667, "Spinal subdural haematoma ": 18.597963196437632, "Spontaneous haematoma ": 7.050913568777228, "Spontaneous haemorrhage ": 8.399404948862976, "Stenosis ": 8.50364786324503, "Stent placement ": 3.002922545190721, "Stress ulcer ": 45.169186461719256, "Subarachnoid haemorrhage ": 13.206684871597894, "Subcutaneous haematoma ": 15.054068821658628, "Subdural haematoma ": 12.624267404495336, "Subdural haemorrhage ": 11.667877528911731, "Systemic inflammatory response syndrome ": 2.806224503145955, "Systolic dysfunction ": 6.265087614804869, "Testicular operation ": 181.5807334887051, "Testicular pain ": 2.894247738709812, "Testicular swelling ": 9.797689393279754, "Thalamus haemorrhage ": 9.871162068719578, "Therapeutic response increased ": 3.769482228217407, "Thrombosis in device ": 19.279328379438024, "Thrombotic thrombocytopenic purpura ": 11.538927724944218, "Tongue haemorrhage ": 11.220882473796092, "Tooth socket haemorrhage ": 18.393981687579338, "Tracheal haemorrhage ": 19.196020756998227, "Transfusion ": 2.2015660794345746, "Transient ischaemic attack ": 3.0829146166854566, "Traumatic haematoma ": 3.863633052239384, "Traumatic intracranial haemorrhage ": 3.936149757584813, "Tricuspid valve incompetence ": 3.489456976490016, "Troponin I increased ": 4.151962780834352, "Troponin increased ": 4.120204313169427, "Tumour haemorrhage ": 6.104643621525225, "Upper gastrointestinal haemorrhage ": 88.80658327964588, "Urethral haemorrhage ": 15.225698256521856, "Urinary bladder haemorrhage ": 10.383615459219037, "Urinary occult blood positive ": 9.7322779630798, "Urogenital haemorrhage ": 17.007714735917535, "Varices oesophageal ": 2.119029957975615, "Vascular injury ": 5.880760708752113, "Vascular pseudoaneurysm ": 29.24821033602416, "Vascular pseudoaneurysm ruptured ": 37.91017685665359, "Vascular stent occlusion ": 13.335926128647149, "Vascular stent stenosis ": 30.14483793828569, "Vascular stent thrombosis ": 49.49765835537662, "Venous occlusion ": 2.7225428198404957, "Ventricular hypokinesia ": 5.800013798325373, "Ventricular tachycardia ": 2.553990895478468, "Vessel puncture site haematoma ": 19.251765545116157, "Vitreous haemorrhage ": 4.172675890538603, "Volvulus ": 3.915238652128057, "Weight abnormal ": 4.88290838968886, "Wound haemorrhage ": 7.108186267693341, "Wound secretion ": 2.2757034980706203} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/278.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/278.json new file mode 100644 index 00000000000..2f420824c84 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/278.json @@ -0,0 +1 @@ +{"Accidental overdose ": 2.514865300231997, "Acidosis ": 4.435461632008114, "Acute kidney injury ": 13.186208718199692, "Agranulocytosis ": 2.2035560940444507, "Altered state of consciousness ": 2.591545190946273, "Angioedema ": 5.2400299785809406, "Anuria ": 3.291196575171782, "Atrioventricular block ": 3.5712353484475465, "Basal cell carcinoma ": 3.7162404085982494, "Blood creatinine increased ": 3.3341121808779857, "Blood glucose fluctuation ": 2.14268050708492, "Blood potassium decreased ": 2.9770733210781364, "Blood potassium increased ": 3.1522324441674123, "Blood pressure decreased ": 2.2726369201445618, "Blood pressure inadequately controlled ": 6.263666661721709, "Blood pressure increased ": 3.808341138846553, "Blood urea increased ": 2.79195058802337, "Blood uric acid increased ": 12.075710679106928, "Bone marrow failure ": 3.4775640447248573, "Bradycardia ": 4.847306922936101, "Cholestasis ": 2.702334436723396, "Colitis microscopic ": 10.291952883887742, "Confusional state ": 3.013941512843148, "Dehydration ": 3.976409313211781, "Dermatitis bullous ": 3.174139406262642, "Diabetes mellitus ": 2.5861781551644336, "Diabetic retinopathy ": 6.396099907645613, "Drug interaction ": 2.8541537934677623, "Drug level above therapeutic ": 12.404933993307871, "Eczema ": 2.304956378315354, "Electrolyte imbalance ": 5.665841999216865, "Eosinophilia ": 2.918363279119889, "Erectile dysfunction ": 4.266488512177378, "Fall ": 3.4922324752691507, "Femur fracture ": 2.3228316756815297, "Foetal monitoring abnormal ": 126.25983099074926, "Gout ": 2.684067517831332, "Haemolytic anaemia ": 2.2740943908133997, "Hepatic cytolysis ": 2.0847063666885, "Hepatitis ": 3.0447273944044584, "Hepatitis acute ": 2.6679218721102904, "Hepatitis cholestatic ": 6.322536131043499, "Hyperammonaemia ": 3.864671508894976, "Hypercalcaemia ": 3.539420538430375, "Hyperglycaemia ": 2.199444625078534, "Hyperkalaemia ": 14.102096608080023, "Hyperlactacidaemia ": 18.75535041828944, "Hypertension ": 2.336777747933982, "Hypertensive crisis ": 8.96606469471373, "Hyperuricaemia ": 11.60637674483948, "Hypochloraemia ": 38.136611886493945, "Hypoglycaemia neonatal ": 18.34306649100582, "Hypokalaemia ": 22.442198740846703, "Hypomagnesaemia ": 3.831961575319198, "Hyponatraemia ": 41.92083150239086, "Hypotension ": 6.107902829432936, "Hypovolaemic shock ": 7.784462777975893, "Inappropriate antidiuretic hormone secretion ": 15.095216283796704, "Interstitial lung disease ": 2.0881863396738662, "Lactic acidosis ": 11.38974419366384, "Medication error ": 4.1382477360439855, "Metabolic acidosis ": 3.7134303281364462, "Oedema peripheral ": 2.6262445763556563, "Oliguria ": 4.8998604666256425, "Orthostatic hypotension ": 17.156338726044677, "Pancreatic carcinoma ": 4.1424290065537965, "Pancreatitis acute ": 5.01959918926064, "Pancytopenia ": 2.0262058440159234, "Photosensitivity reaction ": 4.377082299707135, "Pollakiuria ": 2.082827240578652, "Product colour issue ": 14.589136290493936, "Product contamination microbial ": 407.8546500435292, "Rash maculo-papular ": 3.5207018007645474, "Red blood cell sedimentation rate increased ": 2.4363626137069585, "Renal failure ": 3.9826223539431886, "Rhabdomyolysis ": 2.545874650105217, "Sensory loss ": 3.473306909192497, "Septic shock ": 2.5138671013588394, "Sexual dysfunction ": 3.476057189132695, "Syncope ": 2.074356053283523, "Therapy non-responder ": 4.580113763582156, "Thrombocytopenia ": 2.0004592742243594, "Thrombocytopenic purpura ": 7.531581166139762, "Tinnitus ": 2.1187803314035234, "Tongue oedema ": 4.347240129858233, "Toxic skin eruption ": 8.024413850109012, "Type 2 diabetes mellitus ": 4.672413457709076, "Vertigo ": 2.46631520178594, "Wrong technique in product usage process ": 3.186597936991189} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/279.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/279.json new file mode 100644 index 00000000000..9b1905f043e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/279.json @@ -0,0 +1 @@ +{"Cushing's syndrome ": 128.47280675885344, "Drug interaction ": 12.50292349957808, "Immune reconstitution inflammatory syndrome ": 188.4828077047642, "Neuropathy peripheral ": 6.75889587018508} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/28.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/28.json new file mode 100644 index 00000000000..fa221225945 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/28.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 12.476180096397185, "Blood creatine phosphokinase increased ": 15.445436409911636, "Blood creatinine increased ": 12.223504211243814, "Blood phosphorus decreased ": 505.4596392655991, "Bone pain ": 6.414905892664548, "Drug ineffective ": 5.305748725842466, "Drug resistance ": 162.91823534825764, "Fanconi syndrome acquired ": 68.25145392066845, "Hepatic function abnormal ": 3.9970933837906446, "Hepatitis B DNA increased ": 541.6693372279842, "Osteoporosis ": 4.717083502807063, "Pathogen resistance ": 51.170480911540366, "Product complaint ": 22.58273994844667, "Renal failure ": 2.0294314169901075, "Renal impairment ": 7.132376516903422, "Renal injury ": 3.734831100977009, "Viral infection ": 24.28293418155065, "Viral load increased ": 155.48106806424838} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/280.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/280.json new file mode 100644 index 00000000000..7bd8b87fdda --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/280.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 3.054318742262958, "Anaemia ": 3.337285436015043, "Aspartate aminotransferase increased ": 3.2532484745277603, "Blood creatine phosphokinase increased ": 12.510191807163729, "Blood creatinine increased ": 2.1760195622491394, "Central serous chorioretinopathy ": 172.46883419062755, "Dermatitis acneiform ": 48.64992690740817, "Diarrhoea ": 2.8729822014579907, "Disease progression ": 4.682372325787644, "Drug reaction with eosinophilia and systemic symptoms ": 45.40716088385664, "Ejection fraction decreased ": 10.289766375109766, "Electrocardiogram QT prolonged ": 3.440272932233699, "Erythema ": 2.433090500088479, "Gamma-glutamyltransferase increased ": 3.527311734242254, "Hepatotoxicity ": 9.1304284538417, "Hyperkeratosis ": 35.02899556986354, "Intentional product use issue ": 2.4471090168077203, "Malignant neoplasm progression ": 4.469167450252903, "Metastases to central nervous system ": 20.20165330636985, "Metastatic malignant melanoma ": 95.22920200409833, "Myositis ": 14.818580655751855, "Photosensitivity reaction ": 35.91514071915189, "Pneumonia viral ": 51.45739142043528, "Rash ": 3.806744643833321, "Rash maculo-papular ": 18.162863555680005, "Retinal detachment ": 19.79946613171682, "Retinopathy ": 28.878223960038437, "Skin toxicity ": 179.22251002033113, "Therapy partial responder ": 27.37242856250962, "Toxic skin eruption ": 13.451074447133037, "Transaminases increased ": 4.707810596005276, "Uveitis ": 29.866612985821803} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/281.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/281.json new file mode 100644 index 00000000000..e2fc4ed7d3d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/281.json @@ -0,0 +1 @@ +{"Cerebrovascular accident ": 77.26568312142449, "Confusional state ": 36.001778756256506, "Death ": 5.762492945999524, "Disorientation ": 151.6179261085339, "Speech disorder ": 145.40084618508902} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/282.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/282.json new file mode 100644 index 00000000000..8af1282c582 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/282.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 18.00772595547702, "Blood creatinine increased ": 4.721646151499575, "Drug ineffective ": 2.629436771359388, "Drug interaction ": 2.641293372751392, "Klebsiella infection ": 171.0713704104597, "Muscular weakness ": 3.946657388586083, "Neurotoxicity ": 38.40526030714968, "Overdose ": 3.398565002869733, "Pathogen resistance ": 60.92862420526939, "Vertigo ": 4.081051256129409} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/283.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/283.json new file mode 100644 index 00000000000..1056aff606f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/283.json @@ -0,0 +1 @@ +{"Contusion ": 32.22100194002236, "Dupuytren's contracture ": 3283.2422052339657, "Incorrect dose administered ": 26.17725192161104, "Oedema peripheral ": 33.285720701347, "Skin laceration ": 564.5997339138858, "Tendon rupture ": 179.28475633377508} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/284.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/284.json new file mode 100644 index 00000000000..aa84956adb5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/284.json @@ -0,0 +1 @@ +{"Cough ": 19.742984136044985, "Death ": 3.7444808560178986, "Dyspnoea ": 3.004947404963968, "Haemoptysis ": 26.677273143342997, "Off label use ": 3.560416305220404, "Pneumonia ": 4.677916912542848, "Product physical issue ": 173.9784084673403} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/285.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/285.json new file mode 100644 index 00000000000..ae44e9a664f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/285.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.1397018103290275, "Abnormal dreams ": 2.402627690194404, "Abortion induced ": 20.807068118388536, "Abortion missed ": 15.92037670770376, "Abortion spontaneous ": 7.264560865183492, "Acquired gene mutation ": 24.0434142335154, "Acute pulmonary oedema ": 3.1330727746349, "Adenotonsillectomy ": 477.097705543272, "Adrenogenital syndrome ": 240.005173795878, "Adverse reaction ": 2.0468256303664703, "Alanine aminotransferase increased ": 4.1011758723239495, "Alpha 1 foetoprotein abnormal ": 229.0867695823449, "Alpha 1 foetoprotein increased ": 21.752127181864463, "Ammonia increased ": 3.869856930423088, "Amylase increased ": 3.834942172549373, "Anaemia ": 8.90731609033329, "Anaemia macrocytic ": 90.36771396112262, "Anaemia megaloblastic ": 39.07619223461191, "Anaemia neonatal ": 53.43388190337051, "Anal atresia ": 36.07291863631076, "Anencephaly ": 46.60903777122272, "Angina unstable ": 5.191448261231964, "Anogenital warts ": 37.16774233533396, "Aplasia pure red cell ": 5.211683537367236, "Aplastic anaemia ": 8.483671029155875, "Appendicectomy ": 44.60740897940171, "Arteriosclerosis coronary artery ": 3.210630654223092, "Ascites ": 2.9933114466888284, "Aspartate aminotransferase increased ": 4.403588150559111, "Atrial flutter ": 3.15522514227467, "Atrial septal defect ": 10.796677835076316, "Attention deficit hyperactivity disorder ": 3.8574475549439966, "Blood bilirubin increased ": 5.720541165596119, "Blood creatine phosphokinase increased ": 2.7927875189024887, "Blood lactate dehydrogenase increased ": 4.3035728758008736, "Blood lactic acid increased ": 15.868558367731406, "Blood triglycerides increased ": 2.562798702562856, "Bone marrow failure ": 3.226146820815454, "Brain herniation ": 20.24134123754979, "CD4 lymphocytes decreased ": 40.86046940252768, "Caesarean section ": 27.38231212110665, "Cardiac murmur ": 16.44928080986794, "Cellulitis ": 2.235234738745988, "Cerebellar hypoplasia ": 84.8471967157688, "Cholangitis ": 6.734371444184069, "Cholecystitis ": 4.319460760248536, "Cholestasis ": 2.945362665321805, "Chronic inflammatory demyelinating polyradiculoneuropathy ": 9.845456742801852, "Chronic sinusitis ": 8.872108752399962, "Cleft palate ": 30.021965792978182, "Congenital anomaly ": 18.19216385537997, "Congenital aplasia ": 11.70018866826262, "Congenital central nervous system anomaly ": 54.60220120505437, "Congenital choroid plexus cyst ": 104.51399542322108, "Congenital diaphragmatic hernia ": 51.97426602649128, "Congenital hydrocephalus ": 97.75788308783716, "Congenital hydronephrosis ": 91.38563586304085, "Corneal opacity ": 15.354564899313944, "Cryptorchism ": 27.51490976451842, "Cyst ": 4.001906726626326, "Cytomegalovirus chorioretinitis ": 24.145635615040327, "Cytomegalovirus infection ": 2.597041743714282, "Dandy-Walker syndrome ": 87.95008923313456, "Death neonatal ": 20.711876675652128, "Delivery ": 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17.74221502584702, "Gestational hypertension ": 24.861693204686684, "Granulocytopenia ": 5.003781314045828, "Graves' disease ": 3.986201971449111, "Gynaecomastia ": 3.2681477364346936, "HIV-associated neurocognitive disorder ": 50.75525594379243, "Haemoglobin decreased ": 3.121522919912244, "Haemolytic anaemia ": 7.7129316927656975, "Haptoglobin decreased ": 20.665057068757665, "Heart disease congenital ": 5.062314841351838, "Hepatic cytolysis ": 4.044839150019739, "Hepatic enzyme increased ": 2.724196635579134, "Hepatic failure ": 2.803573999074436, "Hepatic fibrosis ": 8.088944048381823, "Hepatic steatosis ": 5.560928095815048, "Hepatitis ": 5.510310798753819, "Hepatitis B ": 9.94832876686307, "Hepatitis acute ": 2.4135491630461425, "Hepatosplenomegaly ": 9.84831592481146, "Hepatotoxicity ": 4.078806108719815, "Herpes virus infection ": 3.960215327357408, "Hip surgery ": 29.4247876783338, "Hydrocephalus ": 11.704667221039369, "Hydronephrosis ": 10.746430210204553, "Hydrops foetalis ": 36.51244653979159, "Hyperbilirubinaemia ": 9.644926517629614, "Hypercholesterolaemia ": 4.236795279306797, "Hyperchromic anaemia ": 185.9864470141101, "Hyperlactacidaemia ": 10.32615128872965, "Hyperlipidaemia ": 4.525457452996397, "Hypertonia ": 3.0766469571252038, "Hypertriglyceridaemia ": 22.572677471226296, "Hyperuricaemia ": 5.458660354075048, "Hypocalcaemia ": 3.449456698593633, "Hypophosphataemia ": 4.32014210436532, "Hypotonia ": 3.1492794709685703, "Immune reconstitution inflammatory syndrome ": 12.806362652213348, "Inguinal hernia ": 5.414505842323663, "Intellectual disability ": 5.824935971387321, "Jaundice ": 7.379535794035868, "Jaundice neonatal ": 7.267834109154724, "Kaposi's sarcoma ": 26.95667750797016, "Keratopathy ": 32.03417284330178, "Laboratory test abnormal ": 3.758538240824844, "Lactic acidosis ": 4.102785800585461, "Leukopenia ": 2.798437651650655, "Lip discolouration ": 26.47207259420638, "Lipase increased ": 3.386938801884705, "Lipids abnormal ": 24.880789245241147, "Lipoatrophy ": 18.59625241056286, "Lipodystrophy acquired ": 121.14353686676807, "Live birth ": 17.159039974943088, "Liver function test abnormal ": 5.160906144476018, "Low birth weight baby ": 4.569809732683283, "Low set ears ": 55.48362368470901, "Lymphadenitis ": 3.043925803844411, "Macrocytosis ": 26.695846554904747, "Malaria ": 60.12535236189317, "Maternal exposure during pregnancy ": 2.6424769547444047, "Maternal exposure timing unspecified ": 27.75796375603813, "Meconium in amniotic fluid ": 41.224156739232924, "Meningitis tuberculous ": 29.838379456352666, "Meningomyelocele ": 53.79285941713882, "Microcephaly ": 14.905457190049656, "Microcytosis ": 171.16376157047154, "Mitochondrial cytopathy ": 52.83260521541753, "Monoplegia ": 3.015751250058257, "Multiple-drug resistance ": 8.138254552665765, "Myopathy ": 3.215027357134657, "Nail discolouration ": 8.117974909087486, "Nephrolithiasis ": 2.056012805956021, "Nerve injury ": 2.093061644280116, "Neural tube defect ": 54.92696561304764, "Neutropenia ": 2.909324939063025, "Non-Hodgkin's lymphoma ": 5.592901672522456, "Normal newborn ": 40.04443202687385, "Oesophageal ulcer ": 6.6332895650558505, "Oligohydramnios ": 10.299848992273906, "Optic nerve disorder ": 15.585757400271092, "Optic neuritis ": 4.191856692675621, "Optic neuropathy ": 11.184288860664696, "Otitis media ": 7.929004504899535, "Pallor ": 2.710531658381941, "Pancreatic failure ": 56.3254648398669, "Pancreatitis acute ": 2.146778328158112, "Pancytopenia ": 6.285346772838557, "Papilloma ": 118.6214886852543, "Patent ductus arteriosus ": 8.213741271929631, "Pathogen resistance ": 2.996309201601516, "Pharyngitis ": 2.109159832113177, "Placental disorder ": 24.546871304112383, "Plasmablastic lymphoma ": 71.219658842243, "Pneumocystis jirovecii pneumonia ": 4.627442006135585, "Polydactyly ": 95.8083307570583, "Polypectomy ": 139.53448020130247, "Pre-eclampsia ": 7.103361370899588, "Pregnancy ": 36.05845446688756, "Premature baby ": 17.031251404823326, "Premature delivery ": 10.8441398054403, "Premature labour ": 13.47592596315812, "Premature rupture of membranes ": 31.29985680412729, "Prothrombin level decreased ": 8.294196364349702, "Pulmonary tuberculosis ": 9.36722900056363, "Pyelocaliectasis ": 24.966858157739416, "Pyelonephritis ": 6.442216334082375, "Rash maculo-papular ": 2.9336086999229494, "Red blood cell abnormality ": 24.448978223515923, "Renal colic ": 8.644779808125227, "Sinusitis ": 2.298957535510994, "Speech disorder developmental ": 6.2945091065344405, "Spina bifida ": 28.548484528546588, "Spinal fusion surgery ": 47.60456060859282, "Spinocerebellar disorder ": 518.9109229694644, "Splenomegaly ": 4.313373918308522, "Stevens-Johnson syndrome ": 4.075784392133059, "Stillbirth ": 57.30267273245861, "Talipes ": 30.08190886333052, "Thrombocytopenia neonatal ": 73.11391863051134, "Torsade de pointes ": 2.3804226744105392, "Toxic skin eruption ": 2.098781724794677, "Transaminases increased ": 2.4845407021183474, "Treatment noncompliance ": 3.42792753702361, "Trisomy 21 ": 67.38625597794434, "Tuberculosis ": 7.817686107574019, "Ultrasound kidney abnormal ": 191.76965600620247, "Underweight ": 15.18238783912946, "Ventricular septal defect ": 5.457577702051131, "Viral load decreased ": 237.65736056839475, "Viral load increased ": 7.794316609638822, "Viral mutation identified ": 13.018284079113114, "Virologic failure ": 7.704339649386891, "Visual acuity reduced ": 2.0797661191021044, "Visual field defect ": 3.154701654509358} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/286.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/286.json new file mode 100644 index 00000000000..b139fc5f3d8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/286.json @@ -0,0 +1 @@ +{"Abdominal pain lower ": 2.2912591100450763, "Abnormal menstrual clots ": 4.610774565666639, "Abnormal uterine bleeding ": 2.8367571727452314, "Abnormal withdrawal bleeding ": 7.039855133367335, "Acute aseptic arthritis ": 3.454785090503722, "Acute polyneuropathy ": 2.353703880402512, "Acute stress disorder ": 3.9481615494290017, "Acute vestibular syndrome ": 6.211514709348975, "Adenomyosis ": 4.246909728886785, "Administration site erythema ": 4.903241374154537, "Administration site joint pain ": 4.613036758058735, "Administration site lymphadenopathy ": 4.387298973774572, "Administration site movement impairment ": 4.426035853573776, "Administration site oedema ": 9.27841672303305, "Administration site pain ": 10.807532311765884, "Administration site paraesthesia ": 3.734276723501122, "Administration site reaction ": 4.840036543297722, "Adnexa uteri pain ": 6.486851146192079, "Adrenocortical steroid therapy ": 3.870258053096293, "Allergy to arthropod sting ": 2.0804350432753664, "Alopecia areata ": 2.270664624973621, "Amenorrhoea ": 12.423260167497116, "Anaesthesia ": 5.957808206726362, "Anosmia ": 2.4111440495695606, "Anovulatory cycle ": 9.018223918948843, "Anti-thyroid antibody increased ": 4.343951402358383, "Antibody-dependent enhancement ": 7.484139599408403, "Application site hypoaesthesia ": 3.5231563466910822, "Application site lymphadenopathy ": 11.401112698468564, "Application site movement impairment ": 5.827157835572923, "Application site swelling ": 2.016873632289655, "Arrhythmia ": 2.7896177426539377, "Arthralgia ": 2.3975398424383667, "Arthritis reactive ": 2.9583985515168583, "Autoantibody positive ": 4.6386364769013095, "Autoantibody test ": 4.298638432552899, "Autoimmune myositis ": 2.722567538945547, "Axillary lymphadenectomy ": 2.1900734129944857, "Axillary mass ": 4.831571464584694, "Axillary pain ": 7.516416794400517, "Axonal and demyelinating polyneuropathy ": 2.57867857852947, "Basilar artery thrombosis ": 2.831725534817686, "Bell's palsy ": 2.7804679281392986, "Body temperature increased ": 2.432804654573451, "Breakthrough COVID-19 ": 4.009885461607158, "Breast discomfort ": 3.147472992979781, "Breast engorgement ": 6.233782305272988, "Breast enlargement ": 3.351256566633026, "Breast inflammation ": 6.41050713918413, "Breast oedema ": 5.882816660105015, "Breast pain ": 4.408366062322136, "Breast swelling ": 5.213203589977337, "Breast tenderness ": 3.996406142481152, "COVID-19 ": 8.211410280255809, "COVID-19 immunisation ": 4.746335166090454, "COVID-19 pneumonia ": 2.057750211588409, "Capillary fragility ": 2.7819568356795674, "Cardiac discomfort ": 4.978901487778691, "Cardiovascular deconditioning ": 5.133015970635388, "Cardiovascular symptom ": 2.4455259787017978, "Carditis ": 4.956730160555961, "Caregiver ": 5.05061219477771, "Carotid artery dissection ": 3.091901208942295, "Carotid pulse increased ": 3.848447421051007, "Cervicobrachial syndrome ": 3.553588392658761, "Chest discomfort ": 2.172128506329042, "Chest pain ": 2.0014027741041254, "Chillblains ": 3.6256722447224736, "Chills ": 2.2684483213341604, "Chronic fatigue syndrome ": 4.591700454870085, "Chronic idiopathic pain syndrome ": 2.639632555237601, "Circumoral swelling ": 2.855414752375806, "Clinically isolated syndrome ": 2.7311374751197177, "Coital bleeding ": 4.74749618218401, "Cold urticaria ": 2.425283125648158, "Concomitant drug effect decreased ": 3.2939374752118877, "Costochondritis ": 2.1124367550227974, "Cramp-fasciculation syndrome ": 3.80291233442616, "Creutzfeldt-Jakob disease ": 2.312765144319058, "Cystitis noninfective ": 3.914604353285155, "Dengue virus test positive ": 6.732630193117614, "Dermal filler reaction ": 2.556611710984971, "Diaphragmalgia ": 2.2810738365682446, "Disturbance in attention ": 2.06469187703172, "Dysaesthesia ": 3.0784989660561908, "Dysmenorrhoea ": 10.7953701791866, "Ear discomfort ": 2.688286132300856, "Ear inflammation ": 3.947872624508932, "Electrocardiogram PR segment depression ": 6.398561737497216, "Endometriosis ": 3.13651424548092, "Endothelial dysfunction ": 2.554716458727643, "Enhanced respiratory disease ": 5.826477930954527, "Exercise tolerance decreased ": 3.824257425760282, "Exertional headache ": 2.276571794604867, "Extensive swelling of vaccinated limb ": 3.87458736113978, "Extrasystoles ": 2.657279370850107, "Eye haematoma ": 2.272357017338263, "Eye infarction ": 4.901815099408192, "Eye paraesthesia ": 2.512606360107472, "Eyelid haematoma ": 2.2035220165062155, "Eyelid myokymia ": 8.311033944431344, "Facial asymmetry ": 2.032958747477779, "Facial discomfort ": 3.521024837746995, "Facial myokymia ": 6.407483561201405, "Facial nerve disorder ": 2.382157763727566, "Facial paralysis ": 3.669167530961314, "Facial paresis ": 4.797193433870077, "Fatigue ": 2.5862572664641355, "Feeling hot ": 2.713598352262641, "Feeling of body temperature change ": 2.197930317318467, "Fibrin D dimer increased ": 2.799785467472632, "Galactostasis ": 6.216119076216367, "Genital herpes ": 2.668360842875378, "Genital pain ": 2.033515955780333, "Giant cell arteritis ": 2.3283909617517726, "Haemorrhoids thrombosed ": 2.0101434360554293, "Hand dermatitis ": 2.3111801825308653, "Head discomfort ": 2.037629200056689, "Headache ": 2.6377812993112717, "Heart rate variability decreased ": 2.6759737890019, "Heart rate variability increased ": 4.366177200445366, "Heavy menstrual bleeding ": 9.841936438014638, "Hemianaesthesia ": 6.830589123450165, "Hemiataxia ": 2.0402453882154927, "Hemidysaesthesia ": 7.861926840932619, "Hemihyperaesthesia ": 4.84615206062194, "Hemihypoaesthesia ": 8.324923275330095, "Hemiparaesthesia ": 7.000938039619148, "Herpes simplex reactivation ": 2.955895917989765, "Herpes zoster ": 2.243090055306674, "Herpes zoster reactivation ": 2.2601676613157653, "Histamine abnormal ": 2.5861358106910566, "Histamine intolerance ": 4.241330605731263, "Hormone level abnormal ": 3.5060051168511563, "Hyperacusis ": 2.116839263761337, "Hyperaesthesia ": 2.0332315962782808, "Hyperresponsive to stimuli ": 5.196563295091902, "Hypoaesthesia ": 2.276074217052864, "Hypoaesthesia oral ": 2.074327469183596, "Hypomenorrhoea ": 9.508405574782818, "Immunisation ": 48.83361139688855, "Immunisation reaction ": 7.256999281558455, "Immunisation stress-related response ": 6.688910052273217, "Infection susceptibility increased ": 3.325213944130507, "Influenza like illness ": 2.410989598794739, "Injected limb mobility decreased ": 5.63747618979328, "Injection site discomfort ": 2.468223417533542, "Injection site erythema ": 2.154836137268935, "Injection site haematoma ": 3.863586254258995, "Injection site hypoaesthesia ": 3.279454823176971, "Injection site inflammation ": 3.541512045035942, "Injection site joint movement impairment ": 4.773549034603106, "Injection site joint pain ": 2.0185577449333847, "Injection site lymphadenopathy ": 7.570753144330452, "Injection site movement impairment ": 4.000425876547105, "Injection site muscle weakness ": 6.078971809531408, "Injection site oedema ": 2.798774516405392, "Injection site pain ": 4.142683309206558, "Injection site paraesthesia ": 3.068697257100028, "Injection site reaction ": 2.805189104071823, "Injection site swelling ": 3.311375266317887, "Injection site warmth ": 3.2894829813855164, "Interchange of vaccine products ": 21.00655705913473, "Intercostal neuralgia ": 2.692380184403124, "Interferon gamma decreased ": 4.287974352894451, "Interleukin level decreased ": 5.33278085778676, "Intermenstrual bleeding ": 11.099753728844435, "Intestinal barrier dysfunction ": 5.3119641784435485, "Intrauterine contraception ": 7.907296974613479, "Labour pain ": 4.22588558148384, "Lactation disorder ": 2.982256622721679, "Lactation insufficiency ": 6.564920227755662, "Lactation puerperal increased ": 2.7595088998447697, "Laryngeal inflammation ": 2.350955373176944, "Lichen planopilaris ": 2.743845232190221, "Lichen sclerosus ": 2.2413257631804453, "Limb discomfort ": 3.785311125001844, "Lip pruritus ": 2.1272476942727536, "Local reaction ": 2.3585392090681263, "Localised oedema ": 2.1538551058949587, "Loefgren syndrome ": 2.526008366242428, "Lymph node abscess ": 2.034326152502664, "Lymph node pain ": 8.075901685742306, "Lymph node palpable ": 3.726739073197198, "Lymphadenitis ": 7.142222861389564, "Lymphadenopathy ": 7.478022544050123, "Malaise ": 2.6422687249103607, "Mast cell activation syndrome ": 2.404794010561785, "Mastitis ": 2.783125266355148, "Mastitis postpartum ": 11.228648755461542, "Menarche ": 11.58258423488003, "Menometrorrhagia ": 14.867551134262436, "Menstrual clots ": 2.66829793192535, "Menstrual cycle management ": 16.876233111511485, "Menstrual discomfort ": 20.68434401105291, "Menstrual disorder ": 15.235498210707116, "Menstrual headache ": 7.097310558455764, "Menstruation delayed ": 8.3983681665545, "Menstruation irregular ": 10.921590720679024, "Menstruation normal ": 2.7592193060025574, "Migraine with aura ": 2.3141641579140586, "Miller Fisher syndrome ": 2.213068882010747, "Monoparesis ": 2.4788084943555684, "Multisystem inflammatory syndrome ": 2.2910237437353307, "Multisystem inflammatory syndrome in adults ": 2.5915127334107493, "Multisystem inflammatory syndrome in children ": 4.895190768110581, "Muscle strength abnormal ": 2.220914997034065, "Musculoskeletal pain ": 2.1239748392696964, "Myalgia ": 3.426081177760506, "Myalgia intercostal ": 3.755795029612401, "Myelitis ": 3.0083303713832867, "Myocarditis ": 6.197062538509944, "Myokymia ": 7.658790384145563, "Myopericarditis ": 5.3983231716635975, "Nasal herpes ": 3.026368624942601, "Nasal vestibulitis ": 3.616081865482766, "Neck pain ": 2.061385954454366, "Neuralgia ": 2.7076202161824394, "Neuralgic amyotrophy ": 5.649980460817649, "Neuritis ": 2.0918669950175723, "Neurodermatitis ": 2.978623963247665, "Neuromuscular pain ": 2.265036149485321, "New daily persistent headache ": 3.0279954715369333, "Noninfective oophoritis ": 2.7552060383857886, "Nuchal rigidity ": 2.265487973017836, "Occipital neuralgia ": 2.074971587369053, "Oligomenorrhoea ": 17.332305685473493, "Omental infarction ": 2.146884941059276, "Ophthalmic artery occlusion ": 3.2178071789352845, "Ophthalmic artery thrombosis ": 2.146884941059276, "Ophthalmic migraine ": 2.801471198401816, "Ophthalmic vascular thrombosis ": 2.1418821255626903, "Ophthalmic vein thrombosis ": 5.125084534539589, "Oral contraception ": 8.441672520054388, "Oral herpes ": 2.390073072406059, "Oropharyngeal discomfort ": 2.779290323216589, "Ovulation delayed ": 11.453165702058676, "Ovulation disorder ": 9.183405092974358, "Ovulation pain ": 9.93563583106262, "Pain in extremity ": 2.5356407742444707, "Painful respiration ": 3.026459956159598, "Palpitations ": 2.43251858542271, "Paraesthesia ": 3.043902393474709, "Paraesthesia oral ": 2.0204853071541984, "Parosmia ": 2.152650668184402, "Pelvic pain ": 2.5150598844836654, "Performance status decreased ": 3.242313946243213, "Periarthritis ": 2.468570430037872, "Pericardial fibrosis ": 2.691300251014165, "Pericarditis ": 4.70852925776631, "Perichondritis ": 2.687666997909171, "Periorbital discomfort ": 2.1620430088028515, "Peripheral circulatory failure ": 2.2206821637244043, "Peripheral nerve paresis ": 2.5915127334107493, "Pernio-like erythema ": 3.606310516070311, "Pharyngeal paraesthesia ": 2.2457231029240674, "Phobic postural vertigo ": 5.832993491151451, "Pityriasis rosea ": 5.87389143338205, "Polymenorrhagia ": 5.466745188948011, "Polymenorrhoea ": 16.14731686872899, "Polymers allergy ": 2.464852379631598, "Polymyalgia rheumatica ": 3.9922588888628496, "Poor milk ejection reflex ": 5.55088874642594, "Post vaccination syndrome ": 13.416230219233356, "Post-acute COVID-19 syndrome ": 8.180331892970766, "Postmenopausal haemorrhage ": 5.847274064745463, "Postural orthostatic tachycardia syndrome ": 2.6349018986793893, "Pre-existing disease ": 2.9396643527144874, "Pregnancy test negative ": 4.585949489481648, "Premature ovulation ": 4.484089432891292, "Premenstrual dysphoric disorder ": 3.786163247309833, "Premenstrual headache ": 4.660515762898247, "Premenstrual pain ": 8.717170755048063, "Premenstrual syndrome ": 11.47569156296703, "Presyncope ": 2.4906942225785835, "Pulmonary pain ": 2.88929836282156, "Pulse volume decreased ": 2.799662579195312, "Puncture site erythema ": 2.4105878439243185, "Puncture site oedema ": 6.989963951316693, "Puncture site pain ": 9.072289467127945, "Puncture site pruritus ": 5.196563295091902, "Puncture site reaction ": 4.017291734526552, "Puncture site swelling ": 2.1389082728335675, "Rest regimen ": 2.1053360165839483, "Reversed hot-cold sensation ": 2.6927479425134058, "Rheumatic disorder ": 2.89711670611894, "SARS-CoV-2 antibody test ": 2.6320423619467888, "SARS-CoV-2 antibody test negative ": 10.37341959112922, "SARS-CoV-2 antibody test positive ": 3.4412560137489514, "SARS-CoV-2 test negative ": 3.2521150262284872, "SARS-CoV-2 test positive ": 4.549785725458658, "Sacroiliac joint dysfunction ": 2.5861358106910566, "Scar discomfort ": 6.927205357891813, "Scar 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2.4262952268732096, "Tonsillar inflammation ": 2.1904942706014165, "Trigeminal nerve disorder ": 3.0359851947470227, "Trigeminal nerve paresis ": 3.058257117440734, "Trigeminal neuralgia ": 3.029832610545223, "Trigeminal neuritis ": 4.41111651378941, "Trigeminal neuropathy ": 2.4529419997878774, "Troponin ": 2.163403891896227, "Troponin abnormal ": 5.508295369867352, "Troponin increased ": 2.080719252215529, "Unexpected vaginal bleeding on hormonal IUD ": 6.407483561201405, "Urticaria chronic ": 2.3892183203417794, "Uterine inflammation ": 3.0441404208734646, "Uterine pain ": 8.087864480267562, "Uterine spasm ": 4.570349250029271, "Uterine tenderness ": 2.968059819743332, "Vaccination failure ": 10.741579880837469, "Vaccination site anaesthesia ": 2.426729076150728, "Vaccination site atrophy ": 2.1804213082970065, "Vaccination site bruising ": 3.302135301115764, "Vaccination site coldness ": 2.855865068510885, "Vaccination site discharge ": 2.063812368345737, "Vaccination site 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/29.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/29.json new file mode 100644 index 00000000000..43820c2012e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/29.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.095731150133332, "Abdominal distension ": 4.511819407257338, "Acute respiratory failure ": 3.2624012654356576, "Ascites ": 2.994572045662028, "Blood potassium decreased ": 3.204998557492243, "Blood pressure abnormal ": 5.4355459418869145, "Blood pressure decreased ": 5.765291014534246, "Brain natriuretic peptide increased ": 18.55263830961768, "Cardiac failure ": 2.221142067979164, "Cardiothoracic ratio increased ": 259.63979882364947, "Catheter site erythema ": 58.58749674255598, "Catheter site infection ": 37.15445880914137, "Clostridium difficile infection ": 3.517549486517138, "Complication associated with device ": 16.339972209523477, 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"Transfusion ": 7.489274457862896, "Treatment noncompliance ": 2.185169553759043, "Unevaluable event ": 7.043618286334845, "Upper respiratory tract inflammation ": 42.805849628433954, "Uterine haemorrhage ": 9.06019176767264, "Vascular device infection ": 14.688126258422871, "Weight fluctuation ": 14.526967068293562, "Weight increased ": 2.596112598162445} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/290.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/290.json new file mode 100644 index 00000000000..48cd7b69592 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/290.json @@ -0,0 +1 @@ +{"Angina pectoris ": 47.49339020417307, "Aphthous ulcer ": 143.07621289750065, "Arrhythmia ": 22.92917334070321, "Balanoposthitis ": 357.265502649812, "Diarrhoea ": 3.406447806136599, "Drug intolerance ": 22.426553224616264, "Eczema ": 56.141500484418025, "Hypertension ": 8.4274635963524, "Muscle spasms ": 15.520951788371654, "Oropharyngeal pain ": 20.3108929873496, "Pain ": 3.4695799844341626, "Palpitations ": 9.941292060448715, "Polyarthritis ": 332.39268654815885, "Pruritus ": 4.944102466946936, "Rash ": 3.737963742125257, "Tachycardia ": 10.315609476810822, "Vomiting ": 3.670870204583478} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/291.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/291.json new file mode 100644 index 00000000000..4baa087758a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/291.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 7.507020106136249, "Affect lability ": 3.74923040719733, "Aggression ": 3.213791618459928, "Agitation ": 6.700315298240646, "Akinesia ": 135.48880027440038, "Amimia ": 287.49336409222485, "Apathy ": 5.431748990424147, "Aspartate aminotransferase increased ": 2.654184920927416, "Aspiration ": 5.616510836806592, "Balance disorder ": 2.838920545377138, "Behaviour disorder ": 7.093137508086747, "Blood alkaline phosphatase increased ": 3.678638292998556, "Blood creatine phosphokinase increased ": 5.882001423050908, "Blood lactate dehydrogenase increased ": 2.8737626370562177, "Blood pressure fluctuation ": 4.235586943060363, "Bradykinesia ": 24.09326408405268, "C-reactive protein increased ": 3.2063918358434558, "Choking ": 6.046088126811237, "Chromaturia ": 15.02122212759018, "Cognitive disorder ": 2.809042268202215, "Colitis microscopic ": 15.714081148161643, "Coma ": 3.6829835114493887, "Compulsive shopping ": 86.35070521208279, "Confusional state ": 4.003169135381908, "Constipation ": 3.308252349782721, "Corneal reflex decreased ": 163.64007628756076, "Decreased activity ": 5.06970309985907, "Dehydration ": 3.2923144163357216, "Delirium ": 4.029557949027159, "Delusion ": 18.32715472714668, "Dementia ": 3.33866622885214, "Depressed level of consciousness ": 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5.59982229076503, "Rheumatic disorder ": 14.523453796676922, "Road traffic accident ": 4.141294074063699, "Serotonin syndrome ": 3.4868355968211087, "Somnolence ": 2.316880614122529, "Speech disorder ": 2.06224996574895, "Sputum discoloured ": 6.939904049131369, "Sudden onset of sleep ": 117.08395008402184, "Therapeutic product effect delayed ": 17.956448450638707, "Therapeutic response shortened ": 81.8669098850534, "Thymus disorder ": 256.7979562969939, "Tremor ": 2.934138892122291, "Urinary incontinence ": 2.0885651192381705, "Wrong technique in product usage process ": 13.49851266687642} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/292.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/292.json new file mode 100644 index 00000000000..66599bed4f0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/292.json @@ -0,0 +1 @@ +{"Blood creatine phosphokinase 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"Vomiting ": 8.733344386982521} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/294.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/294.json new file mode 100644 index 00000000000..04c856e1d40 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/294.json @@ -0,0 +1 @@ +{"Anhedonia ": 3.1655396872128843, "Anxiety ": 2.439137521797732, "Balance disorder ": 4.5160249647354895, "Bone pain ": 2.739135943318313, "Burning sensation ": 4.498329746871734, "Deformity ": 78.4155383283577, "Dry skin ": 21.77286039616827, "Emotional distress ": 4.303460161890472, "Erythema ": 3.385126887416767, "Extremity contracture ": 410.1498784139749, "Fibrosis ": 70.83132362950919, "Gait inability ": 3.691080789939184, "General physical health deterioration ": 5.581448467924595, "Hyperkeratosis ": 29.147141242189623, "Injury ": 10.158087729769807, "Joint range of motion decreased ": 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file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/295.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/295.json new file mode 100644 index 00000000000..119f8ebd336 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/295.json @@ -0,0 +1 @@ +{"Blood pressure increased ": 7.09155877008656, "Oedema peripheral ": 11.175338583637824, "Wrong technique in product usage process ": 24.675147702071957} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/296.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/296.json new file mode 100644 index 00000000000..12e144726c7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/296.json @@ -0,0 +1 @@ +{"Diabetes mellitus inadequate control ": 10.742450278118293, "Drug interaction ": 2.016172609503253, "Drug resistance ": 18.85088162336985, "Exposure during pregnancy ": 5.354484636240363, "Hyperglycaemia ": 5.656524775072676, "Hypoglycaemia ": 4.263958426578721, "Neutropenia ": 4.329783256470271, "Sepsis ": 3.526667121433084, "Tendon rupture ": 43.66720773922663} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/297.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/297.json new file mode 100644 index 00000000000..7926ff1f129 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/297.json @@ -0,0 +1 @@ +{"Ammonia increased ": 66.1559910842339, "Atrioventricular block ": 26.20967723560282, "Blood glucose increased ": 3.979184796112179, "Drug ineffective ": 2.8646507179211107, "Electrocardiogram QT prolonged ": 6.182824181576268, "Extrapyramidal disorder ": 17.00860541866718, "Heart rate decreased ": 10.77143943380814, "Hyperglycaemia ": 5.122187241592768, "Maternal exposure during pregnancy ": 4.2380256575224085, "Premature delivery ": 22.918067778130204, "Presyncope ": 4.854771962447388, "Sepsis ": 2.982044049604561, "Tendon rupture ": 38.47378654180518, "Therapeutic product effect decreased ": 6.573842814511015} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/298.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/298.json new file mode 100644 index 00000000000..1be13b336be --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/298.json @@ -0,0 +1 @@ +{"Abscess ": 2.52569870338455, "Abscess limb ": 4.36418901000244, "Accidental exposure to product ": 7.912577665945781, "Accidental underdose ": 2.328176361134584, "Acne ": 2.2428569208046785, "Acrochordon ": 12.097881620985778, "Actinic keratosis ": 5.072209229141919, "Acute febrile neutrophilic dermatosis ": 3.291637019025799, "Adenocarcinoma of colon ": 2.96946792068669, "Adjustment disorder with 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irregularity ": 4.893033449740591, "Bronchitis ": 2.571864779374616, "Bursitis ": 3.795303492856888, "C-reactive protein ": 4.4201398535117855, "C-reactive protein abnormal ": 3.9448274322019774, "C-reactive protein increased ": 4.870262000043046, "Candida infection ": 6.045459919024995, "Cellulitis ": 3.4703959725346887, "Chest injury ": 6.3104677877748845, "Chronic disease ": 23.99814600976756, "Colitis ": 3.492756924230825, "Colitis microscopic ": 4.077599122346428, "Colitis ulcerative ": 6.019661948714094, "Concomitant disease aggravated ": 8.250146883396864, "Concomitant disease progression ": 2.954334194473744, "Conjunctivitis ": 3.196776240243239, "Contraindicated product prescribed ": 9.612736943103892, "Coronavirus infection ": 6.081690773725959, "Coronavirus test positive ": 8.119223556548526, "Costochondritis ": 3.610212928150271, "Crepitations ": 2.0553382281969568, "Crohn's disease ": 10.749434728169051, "Cutaneous T-cell lymphoma ": 7.431602326619571, "Cutaneous symptom ": 6.216520658971286, "Cutaneous vasculitis ": 2.503334291939256, "Cyst ": 2.2259686668919585, "Cystitis noninfective ": 2.509603929525813, "Dactylitis ": 91.03610429089922, "Decreased immune responsiveness ": 5.529363435880501, "Deep vein thrombosis postoperative ": 2.4346307453061944, "Defaecation urgency ": 3.992513109940826, "Dermatitis atopic ": 2.191661171766386, "Dermatitis exfoliative generalised ": 4.553229767904019, "Dermatitis psoriasiform ": 10.67243489242479, "Device defective ": 15.197844020900003, "Device delivery system issue ": 2.1347816771147965, "Device difficult to use ": 4.434522644785563, "Device issue ": 9.570934941244367, "Device leakage ": 5.112306632269688, "Device malfunction ": 3.266931655760719, "Diarrhoea haemorrhagic ": 4.566369699487118, "Discomfort ": 2.145706096494832, "Dislocation of vertebra ": 3.811897343632617, "Diverticulitis ": 2.804862020322839, "Drug dose omission by device ": 6.135189950199675, "Drug effect less than expected ": 3.0372034535735777, "Drug hypersensitivity ": 2.3337439615204767, "Drug ineffective ": 3.475136686903724, "Drug intolerance ": 3.58841703098957, "Dry eye ": 2.0700465359581317, "Dry skin ": 3.1681051714708093, "Duodenal ulcer perforation ": 2.0646421585826, "Dyshidrotic eczema ": 8.783593857812683, "Ear disorder ": 4.05748409752101, "Ear infection ": 2.9954445257016973, "Ear injury ": 27.19132323118374, "Ear neoplasm ": 66.08935205959591, "Ear pruritus ": 3.0734887906043507, "Early satiety ": 9.073528726766863, "Eczema ": 3.6496983025429497, "Endometriosis ": 2.5539051015581298, "Enteritis ": 3.3092100893222827, "Enthesopathy ": 39.089396612690194, "Epicondylitis ": 4.008275732381999, "Erosive oesophagitis ": 2.948777973245726, "Erysipelas ": 5.607921656211831, "Erythema nodosum ": 3.3776974736758074, "Erythrodermic psoriasis ": 36.56684205670264, "Exposure via partner ": 33.01741294795728, "Eye discharge ": 2.450177049765646, "Eye infection ": 3.0420848318206075, "Facet joint syndrome ": 3.220238694208837, "Faecal calprotectin increased ": 6.0129409029097545, "Fear of injection ": 6.984317907002021, "Fibromyalgia ": 2.4855993938368783, "Finger deformity ": 2.8642970779499137, "Fistula ": 2.4095890673210354, "Folliculitis ": 3.7987659768374793, "Food aversion ": 4.437244035441716, "Fungal infection ": 5.684832874673858, "Furuncle ": 6.551826109813355, "Gastrectomy ": 22.427734851461462, "Gastrointestinal candidiasis ": 11.43218775067814, "Gastrointestinal disorder ": 2.402319398403429, "Gastrointestinal infection ": 3.09794455258931, "Gastrointestinal inflammation ": 4.1816844459102445, "Genital candidiasis ": 10.840906674017862, "Grip strength decreased ": 3.018134458158565, "Guttate psoriasis ": 11.3743299482559, "Haemangioma of skin ": 12.872230297427013, "Haematochezia ": 2.2197076841544248, "Haemorrhagic diathesis ": 2.782832673692019, "Hangover ": 2.1898544143979284, "Hepatic enzyme abnormal ": 3.670627463410838, "Hepatic steatosis ": 3.1343212748256826, "Hereditary motor and sensory neuropathy ": 32.82005858996298, "Hidradenitis ": 23.246949127168527, "Hordeolum ": 2.834271164812374, "Hypertriglyceridaemia ": 2.4572363129928765, "Immune system disorder ": 2.097659493482929, "Immunodeficiency ": 2.918430167373996, "Immunosuppression ": 4.439740198690783, "Impetigo ": 4.772251005820685, "Inappropriate schedule of product administration ": 6.250176592315128, "Incorrect dose administered ": 4.586620865936073, "Incorrect dose administered by device ": 5.801520629896028, "Incorrect route of product administration ": 3.514905890379844, "Infection ": 2.8675140210450927, "Infection susceptibility increased ": 4.296125625596934, "Inflammation ": 3.589610271419706, "Inflammatory bowel disease ": 64.29945591752977, "Inflammatory marker increased ": 2.503911933639708, "Inflammatory pain ": 16.044364273902605, "Injection site bruising ": 5.116924717067456, "Injection site discharge ": 9.428336623359266, "Injection site haemorrhage ": 4.676857768114068, "Injection site mass ": 3.207441747723927, "Intervertebral disc degeneration ": 2.287497937807741, "Investigation abnormal ": 8.276375766553237, "Iodine allergy ": 27.8583954251844, "Iridocyclitis ": 3.038457437875414, "Iritis ": 10.13588049167989, "Joint ankylosis ": 59.35353231004366, "Joint noise ": 3.201232425602569, "Joint range of motion decreased ": 6.383593828039476, "Joint stiffness ": 4.589818025062403, "Joint swelling ": 4.798686794716206, "Juvenile idiopathic arthritis ": 5.946446007780346, "KL-6 increased ": 6.994506588095212, "Kidney infection ": 2.669989993338089, "Large intestinal ulcer ": 2.842273172174308, "Laryngitis ": 3.970729552398789, "Latent tuberculosis ": 5.61445558545964, "Lentigo ": 44.756918601738896, "Lichen planus ": 4.228770675892275, "Lid sulcus deepened ": 15.520567113427768, "Lip dry ": 4.289316321982557, "Lip ulceration ": 6.169311991799358, "Lipoma ": 4.016182886060782, "Liver abscess ": 2.044992251511394, "Liver function test increased ": 3.012499009497676, "Loss of therapeutic response ": 18.901397180474618, "Lower gastrointestinal haemorrhage ": 5.791728642525092, "Lower limb fracture ": 2.052638464248524, "Lower respiratory tract congestion ": 14.648129714292685, "Lower respiratory tract infection ": 3.629777892119733, "Lower respiratory tract infection viral ": 21.99319991174285, "Lumbar spinal stenosis ": 3.207181305701119, "Lumbar vertebral fracture ": 4.873164840223964, "Lupus vulgaris ": 12.144596227927536, "Lupus-like syndrome ": 7.123378979068758, "Lyme disease ": 2.410843394885977, "Macule ": 6.390419258282256, "Malignant melanoma ": 2.524605838198359, "Mammoplasty ": 24.59267791278567, "Maternal exposure timing unspecified ": 5.557354257826239, "Melanocytic naevus ": 6.958519350054344, "Meniscus injury ": 4.474738329991791, "Mouth ulceration ": 3.685254843293102, "Mucous stools ": 2.5304662289178874, "Muscle atrophy ": 2.0121848816990338, "Muscle injury ": 4.395911360423021, "Muscle strain ": 3.952619581341313, "Musculoskeletal discomfort ": 3.5365620806802784, "Musculoskeletal pain ": 3.9722130393392767, "Musculoskeletal stiffness ": 5.495285825912794, "Mycobacterium tuberculosis complex test positive ": 9.647511425556411, "Mycotic allergy ": 6.427548504386733, "Nail disorder ": 3.4036219832946166, "Nail psoriasis ": 44.25870098606173, "Nasal crusting ": 24.603209856284334, "Nasal dryness ": 3.827693385275481, "Nasal inflammation ": 7.913814465870637, "Nasopharyngitis ": 4.428489005334835, "Neck pain ": 2.583259689843464, "Needle issue ": 6.358657303781159, "Neoplasm skin ": 5.27623807433815, "Nervous system disorder ": 2.24123722361904, "Neurodermatitis ": 3.995171721601437, "Nodule ": 2.669989993338089, "Normal newborn ": 3.969452053546088, "Obesity ": 3.3587241289799405, "Occult blood ": 8.706968915985879, "Oesophageal candidiasis ": 20.51816627698332, "Oesophageal stenosis ": 3.171997578848048, "Oesophageal ulcer ": 2.40515574524744, "Onycholysis ": 14.648129714292685, "Onychomycosis ": 2.2629235716491465, "Oral candidiasis ": 8.810117655092354, "Oral disorder ": 2.12682000959752, "Oral fungal infection ": 7.325967297772159, "Oral herpes ": 3.5874707218909667, "Oropharyngeal candidiasis ": 9.963380005889906, "Oropharyngeal pain ": 2.3821924009514395, "Osteoarthritis ": 4.137215310531088, "Otitis externa ": 10.757771677203424, "Otitis media ": 2.273908166734489, "Overweight ": 2.2880288254742767, "Pain of skin ": 2.575693410398263, "Palmoplantar pustulosis ": 37.98178771646722, "Papillary thyroid cancer ": 3.118088943510042, "Papule ": 4.101512271149069, "Paradoxical drug reaction ": 4.452448100510977, "Paradoxical psoriasis ": 28.843392104841904, "Paternal exposure during pregnancy ": 21.274910866504865, "Pelvic pain ": 2.842511887247708, "Peptic ulcer ": 4.725003900887934, "Peripheral venous disease ": 5.795138036411785, "Peritonsillar abscess ": 6.5848138188840855, "Pharyngitis ": 3.3515868093988828, "Pharyngitis streptococcal ": 6.251497993451569, "Phlebectomy ": 227.33299859301476, "Pigmentation disorder ": 2.1484689460044644, "Plantar fasciitis ": 3.963878381610708, "Pneumomediastinum ": 5.403606201727981, "Polyarthritis ": 2.8142327480251423, "Polycythaemia ": 7.965017940283153, "Post procedural infection ": 3.4569787862136243, "Product prescribing error ": 5.04855056575651, "Product supply issue ": 3.1035205710981297, "Productive cough ": 2.0279462924027083, "Psoriasis ": 39.92569355554707, "Psoriasis area severity index increased ": 80.19648950652187, "Psoriatic arthropathy ": 48.11329056998748, "Pustular psoriasis ": 23.172161021986867, "Pustule ": 6.540052962106897, "Pyoderma gangrenosum ": 5.891223976755102, "Rebound psoriasis ": 161.27938876942102, "Red blood cell sedimentation rate abnormal ": 5.642331779471181, "Red blood cell sedimentation rate increased ": 3.836412460617568, "Reflux gastritis ": 7.212499626338817, "Respiratory tract congestion ": 3.045733925402601, "Respiratory tract infection ": 3.143105094469613, "Rheumatic disorder ": 3.4180364181895464, "Rheumatic fever ": 6.047443122014809, "Rheumatoid arthritis ": 2.4841217416482557, "Rheumatoid factor positive ": 2.9875583937413666, "Rheumatoid nodule ": 5.595523023708395, "Rhinalgia ": 2.0550116016899658, "Rhinitis ": 2.0949740769619307, "Rhinorrhoea ": 2.543777205374451, "Sacral pain ": 5.821039060833801, "Sacroiliitis ": 19.029228100966705, "Scab ": 3.095811686173851, "Scar ": 2.3874912427344634, "Sciatica ": 4.055659332945938, "Scratch ": 5.547707903406603, "Seborrhoeic keratosis ": 21.611715625301198, "Secretion discharge ": 3.0352745286884857, "Self-consciousness ": 65.1095301150832, "Seronegative arthritis ": 19.946554934259595, "Sinonasal obstruction ": 11.382685651781973, "Sinus congestion ": 5.102520606158166, "Sinusitis ": 2.546945650341358, "Sjogren's syndrome ": 4.619092315069047, "Skin atrophy ": 2.4692166962664155, "Skin candida ": 20.578440603673084, "Skin depigmentation ": 3.16153305920081, "Skin disorder ": 3.736584258574296, "Skin exfoliation ": 4.968453040818748, "Skin fissures ": 5.682529090247976, "Skin haemorrhage ": 3.8344653786538543, "Skin hyperpigmentation ": 2.1340577362344697, "Skin hypertrophy ": 2.362568881825132, "Skin infection ": 2.7954161507559085, "Skin injury ": 3.938117823531039, "Skin lesion ": 8.08071623801856, "Skin mass ": 2.271506956394293, "Skin oedema ": 4.727968228820789, "Skin plaque ": 21.43006714705332, "Skin reaction ": 3.124216619833983, "Skin striae ": 3.662838799088658, "Skin wrinkling ": 4.698107230938798, "Sleep disorder due to general medical condition, hypersomnia type ": 143.69406594625357, "Somatic symptom disorder ": 2.216457840070845, "Spinal cord injury ": 10.174043451640424, "Spinal disorder ": 2.3270778295164583, "Spinal fusion surgery ": 2.397518654080057, "Spinal osteoarthritis ": 3.490399788800685, "Spinal pain ": 5.867844456714221, "Spinal stenosis ": 2.700813243213789, "Spondylitis ": 13.98240758343183, "Spondyloarthropathy ": 8.460794831368258, "Sputum discoloured ": 2.168630957434489, "Squamous cell carcinoma ": 2.151391849814364, "Staphylococcal infection ": 3.353025914641464, "Staphylococcal skin infection ": 8.742535551625716, "Staphylococcus test positive ": 2.7300292250070206, "Streptococcal infection ": 2.282523152190114, "Stress ": 2.9579064394750483, "Subcutaneous abscess ": 4.777035945422512, "Sunburn ": 3.093040029734667, "Swollen joint count ": 193.90144038620733, "Swollen joint count increased ": 6.280970407557677, "Symptom recurrence ": 9.20038656979777, "Synovial cyst ": 4.07387817867366, "Synovial disorder ": 20.44162869518447, "Synovitis ": 6.595041069634799, "Syringe issue ": 2.7156098018006425, "Telangiectasia ": 6.60480688470877, "Temporomandibular pain and dysfunction syndrome ": 5.05561558739295, "Tender joint count ": 190.28093922693932, "Tenderness ": 3.2346361041891734, "Tendon disorder ": 3.1349674617273133, "Tendonitis ": 2.472584472184263, "Tenosynovitis ": 14.289532217459625, "Terminal insomnia ": 7.886366758001173, "Therapeutic product effect decreased ": 4.677005106448232, "Therapeutic product effect delayed ": 2.425279654508431, "Therapeutic product effect incomplete ": 5.332645697918995, "Therapeutic response decreased ": 2.22522123528002, "Therapeutic response shortened ": 21.37171415345446, "Therapy non-responder ": 3.606394028063796, "Tinea pedis ": 21.988833235846776, "Tonsillar ulcer ": 77.85689721946959, "Tonsillitis ": 9.48165577894944, "Tooth abscess ": 9.125719320318892, "Treatment failure ": 6.406599800566071, "Trismus ": 3.1392118605221366, "Tuberculin test positive ": 4.117996980403709, "Tuberculosis ": 4.601726040171987, "Type 2 diabetes mellitus ": 2.3279311612414126, "Upper respiratory tract infection ": 2.8060854575602976, "Urticarial vasculitis ": 4.273948313706167, "Uveitis ": 10.97550471415921, "Vaginal infection ": 17.162057805852516, "Vitiligo ": 4.257702294001496, "Vulvovaginal candidiasis ": 9.740006650404643, "Vulvovaginal mycotic infection ": 4.146334966831085, "Wound infection ": 2.3432564418864805, "Wound secretion ": 5.913793630213956, "Wrong technique in device usage process ": 2.870427212535945} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/299.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/299.json new file mode 100644 index 00000000000..3ae237e03b7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/299.json @@ -0,0 +1 @@ +{"Acne ": 3.555496705658454, "Acute kidney injury ": 2.278549547279668, "Aphthous ulcer ": 5.273353831346296, "Aspartate aminotransferase increased ": 2.138368435203255, "Blood alkaline phosphatase increased ": 4.519842431229907, "Blood bilirubin increased ": 2.102718310832065, "Blood creatine phosphokinase increased ": 6.72026706243508, "Blood creatinine increased ": 2.293544211276965, "Blood lactate dehydrogenase increased ": 4.249604998943078, "Cardiomyopathy ": 4.832497607997906, "Central serous chorioretinopathy ": 78.12012832584566, "Cholestasis ": 11.8751675120925, "Conjunctivitis ": 4.028240801491386, "Cytokine release syndrome ": 2.0423892588583823, "Death ": 3.509511679071972, "Dermatitis ": 4.807930120966674, "Dermatitis acneiform ": 62.81203508210757, "Dermatitis allergic ": 3.560205889772776, "Diarrhoea ": 4.079931491761429, "Disease progression ": 2.3066045223220164, "Drug reaction with eosinophilia and systemic symptoms ": 34.60012310026578, "Ejection fraction decreased ": 14.841143333941892, "Electrocardiogram QT prolonged ": 2.1219654170119924, "Eosinophilia ": 2.8094752618794923, "Erythema multiforme ": 3.710378415420109, "Erythema nodosum ": 19.465977813204223, "Face oedema ": 6.139019589925036, "Folliculitis ": 6.105949189442965, "Gamma-glutamyltransferase increased ": 2.860585250027473, "Gastritis ": 2.358326745641816, "General physical health deterioration ": 2.709891744217398, "Hepatic cytolysis ": 9.540794144793823, "Hepatitis ": 3.553001960603466, "Hepatotoxicity ": 3.9147110418945696, "Hyperthermia ": 4.8817078958393765, "Hypertransaminasaemia ": 5.8447392057766345, "Intentional product use issue ": 8.626283045552423, "Intestinal obstruction ": 3.0566396679970795, "Intracranial pressure increased ": 9.021462063065089, "Iridocyclitis ": 12.17139752720167, "Laryngeal oedema ": 3.5443050167870074, "Lip oedema ": 4.096246433612609, "Liver function test increased ": 2.334919296695529, "Lymphopenia ": 3.783710496363629, "Macular oedema ": 18.16314842919592, "Malignant melanoma ": 5.734243465443444, "Metastases to central nervous system ": 16.145387217005425, "Metastasis ": 15.896274964634316, "Metastatic malignant melanoma ": 15.604456715116802, "Mucosal inflammation ": 8.15032580005422, "Ocular toxicity ": 93.4614007033173, "Off label use ": 2.1227006688595136, "Pancreatitis acute ": 2.198002288287974, "Panniculitis ": 34.98819975996297, "Photosensitivity reaction ": 48.65962371824853, "Pneumonitis ": 2.678370267489312, "Purpura ": 7.653219576577805, "Rash ": 5.313415021004291, "Rash erythematous ": 3.0379560305764066, "Rash macular ": 3.698550424992341, "Rash maculo-papular ": 18.955030211616936, "Rash morbilliform ": 3.659702749891444, "Rash papular ": 6.08799769093459, "Rash pustular ": 11.840390810471607, "Renal failure ": 2.4691754387645224, "Retinal detachment ": 15.115697027713354, "Retinal vein occlusion ": 12.765318213638976, "Retinopathy ": 14.781719428488843, "Rhabdomyolysis ": 5.010526842130283, "Sarcoidosis ": 8.190375012864958, "Sepsis ": 2.101910402749798, "Serous retinal detachment ": 107.21847583932563, "Serous retinopathy ": 409.36206245802754, "Skin exfoliation ": 5.075520784789844, "Skin lesion ": 2.48213174438987, "Skin reaction ": 5.304706672132148, "Skin toxicity ": 64.83311325050242, "Solar dermatitis ": 156.49582911159865, "Stevens-Johnson syndrome ": 10.40663698851975, "Stomatitis ": 4.336394529183146, "Sunburn ": 17.956077288190652, "Systemic inflammatory response syndrome ": 12.000473504775988, "Toxic epidermal necrolysis ": 2.310534855042937, "Toxic skin eruption ": 17.50779306578391, "Transaminases increased ": 4.383722364188557, "Uveitis ": 32.431906243672366} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/3.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/3.json new file mode 100644 index 00000000000..409fdfe0a12 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/3.json @@ -0,0 +1 @@ +{"Accidental underdose ": 181.5460973674148, "Blood glucose abnormal ": 67.53836703459412, "Blood glucose decreased ": 19.4507735038502, "Blood glucose fluctuation ": 29.97973339863641, "Blood glucose increased ": 36.43872731950109, "Device malfunction ": 2.7363928615479134, "Diabetes mellitus inadequate control ": 13.576814997310883, "Drug hypersensitivity ": 2.5685925801274303, "Drug ineffective ": 2.380551933999816, "Feeling abnormal ": 2.0872196196020334, "Flatulence ": 2.3712220495380154, "Glycosylated haemoglobin increased ": 46.47747577782364, "Hyperglycaemia ": 16.96847515543729, "Hyperinsulinaemic hypoglycaemia ": 65.58767067997874, "Hypoglycaemia ": 27.4716490677543, "Hypoglycaemic coma ": 9.719689281518743, "Incorrect dose administered ": 26.08744557641807, "Incorrect product administration duration ": 7.1564066121743215, "Increased appetite ": 4.18889015468786, "Injection site bruising ": 11.780928036942004, "Injection site erythema ": 2.1638517789902854, "Injection site haematoma ": 2.4163040735604557, "Injection site haemorrhage ": 19.351303492751885, "Injection site mass ": 10.178046675029629, "Injection site pain ": 5.027834730728956, "Injection site pruritus ": 4.789358893265909, "Injection site rash ": 7.09270767931323, "Injection site reaction ": 2.407472071824382, "Injection site urticaria ": 8.595450092692062, "Injury associated with device ": 22.5503474954124, "Ketoacidosis ": 6.167752790524029, "Lipodystrophy acquired ": 8.842062201004781, "Nocturia ": 5.710478804883988, "Pancreatic carcinoma ": 2.1075353199285973, "Product administration error ": 2.476840969105917, "Product dose omission issue ": 6.9774223695475, "Product storage error ": 17.368902802593887, "Product substitution issue ": 7.750088083341915, "Pruritus ": 2.934934147561611, "Rash pruritic ": 2.645049380968972, "Skin reaction ": 2.0084283033524843, "Therapeutic response unexpected ": 27.087702835363736, "Visual impairment ": 3.506080805167576, "Weight decreased ": 2.27398926473085, "Weight increased ": 4.88030913240921, "Wound ": 2.4510006868617524, "Wrong product administered ": 12.477415229121013, "Wrong technique in product usage process ": 2.684229180269249} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/30.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/30.json new file mode 100644 index 00000000000..323fd44ddf9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/30.json @@ -0,0 +1 @@ +{"Activated partial thromboplastin time abnormal ": 374.1761842739554, "Acute coronary syndrome ": 13.710295525165574, "Acute kidney injury ": 10.818448560387464, "Acute myocardial infarction ": 2.3601018908115656, "Agranulocytosis ": 5.867633198958331, "Angina unstable ": 15.484833348324916, "Aortic arteriosclerosis ": 23.49110535832396, "Ascites ": 2.188161820677574, "Atrial fibrillation ": 3.249946301836666, "Benign prostatic hyperplasia ": 13.099471940821651, "Blood bilirubin abnormal ": 53.82988560392123, "Blood creatine phosphokinase increased ": 3.2755392050165577, "Blood glucose abnormal ": 4.063265812431441, "Cardiac failure ": 3.3822210632874974, "Cerebral haemorrhage ": 2.6200366421881203, "Cholestasis ": 5.40001376007055, "Dermatitis bullous ": 6.514832155554581, "Dermatitis exfoliative generalised ": 7.674214458958129, "Diarrhoea ": 2.184277298427641, "Eosinophilia ": 4.997639530733817, "Gamma-glutamyltransferase increased ": 2.2324113750861883, "Gout ": 45.30652748015892, "Haematocrit abnormal ": 84.86288409180669, "Haematocrit decreased ": 3.660531441984818, "Haemoglobin abnormal ": 17.513713306348304, "Haemoglobin urine present ": 553.1129733142666, "Hepatic cyst ": 24.891713854811687, "Hepatic cytolysis ": 5.323263611438191, "Hepatic lesion ": 16.33422370365732, "Hiatus hernia ": 5.58467613474207, "Hyperkalaemia ": 9.7812557148707, "Hypertriglyceridaemia ": 9.960953698040502, "International normalised ratio abnormal ": 47.30346194139375, "Lactic acidosis ": 5.490190426958176, "Liver function test abnormal ": 2.564100772432423, "Lordosis ": 180.51049166018075, "Lung opacity ": 13.713146368286308, "Mean cell haemoglobin increased ": 64.78516098067134, "Mean cell volume increased ": 47.9568886855016, "Mesenteric vein thrombosis ": 46.56288698766726, "Metastases to soft tissue ": 223.2416131666521, "Nasal congestion ": 6.067665667193415, "Oedema peripheral ": 2.746627518993653, "Osteochondrosis ": 71.51681785343544, "Osteolysis ": 49.3448447442696, "Osteoma ": 508.8565670154496, "Pancreatitis ": 2.142315086416051, "Pancreatitis acute ": 6.241606018796652, "Pancytopenia ": 4.301883514820562, "Photosensitivity reaction ": 3.5830813384944955, "Platelet count abnormal ": 17.25268611390025, "Polycystic liver disease ": 1213.679415045924, "Prostatic specific antigen abnormal ": 133.27292678749092, "Prothrombin time abnormal ": 250.0058291022553, "Pruritus ": 3.276291395375459, "Rash ": 2.000683397842741, "Rash macular ": 2.622158722603908, "Rash maculo-papular ": 2.9882795692359645, "Red blood cell abnormality ": 75.9988236208984, "Red blood cell count decreased ": 3.826591863159615, "Red blood cells urine positive ": 109.25715683691053, "Renal failure ": 2.572935342165042, "Renal impairment ": 2.392078854808924, "Rhabdomyolysis ": 5.0221998599265705, "Scoliosis ": 13.97655697077372, "Sensory disturbance ": 2.8412808358131, "Shock haemorrhagic ": 11.700086132993825, "Skin exfoliation ": 3.1840999384873645, "Spinal osteoarthritis ": 10.772252213981892, "Splenic cyst ": 480.0525267081996, "Splenic lesion ": 237.83925840689983, "Splenic necrosis ": 943.002815407432, "Stevens-Johnson syndrome ": 2.026528621078504, "Sudden death ": 4.778796087495595, "Toxic epidermal necrolysis ": 2.740091497767901, "Toxic skin eruption ": 3.766647909585721, "Transaminases increased ": 3.5150908868305195, "Transient ischaemic attack ": 2.181374642818948, "Troponin increased ": 11.78349675767964, "Tubulointerstitial nephritis ": 7.123455241857869, "Underdose ": 5.751806739494086, "Urinary sediment present ": 206.91405336777973, "White blood cells urine positive ": 59.34975512620794, "Wrong technique in product usage process ": 5.087540655383932} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/300.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/300.json new file mode 100644 index 00000000000..f3e0ab80967 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/300.json @@ -0,0 +1 @@ +{"Acetonaemic vomiting ": 4.546024796603692, "Achenbach syndrome ": 4.4596667087219055, "Adverse event following immunisation ": 6.096755654613295, "Analgesic drug level ": 7.125327741332961, "Aortic embolus ": 11.339416126085275, "Application site bruise ": 2.14016194061601, "Application site pain ": 10.221302054320926, "Application site reaction ": 5.012030946021421, "Application site swelling ": 4.9708971392042685, "Arthralgia ": 3.656683919396985, "Asthenopia ": 4.21908167496616, "Bacille Calmette-Guerin scar reactivation ": 3.08879576801702, "Blood glucose ": 4.083143474442781, "Blood iron ": 7.9770953345728195, "Blood pH ": 13.840275549514487, "Blood pressure measurement ": 4.830527799155113, "Blood test ": 3.60503979279196, "Blue toe syndrome ": 2.248405392731321, "Body temperature ": 25.14779783555042, "Body temperature abnormal ": 6.409983627235924, "Body temperature fluctuation ": 3.963407861483574, "Body temperature increased ": 2.7458390831097987, "Burning feet syndrome ": 2.9877618189352444, "Cavernous sinus thrombosis ": 2.262719745072532, "Cerebral venous sinus thrombosis ": 3.9754885833761295, "Chest crushing ": 4.288963038675858, "Chillblains ": 2.105023455263645, "Chills ": 5.88157733035379, "Cluster headache ": 10.246807404489584, "Cold sweat ": 2.868780119539569, "Cold-stimulus headache ": 8.141540000771561, "Computerised tomogram head ": 6.657436399885064, "Constricted affect ": 2.946861043036056, "Contusion ": 2.257302088104975, "Coronavirus test ": 37.84405664697479, "Delirium febrile ": 3.1941370078078286, "Dental paraesthesia ": 2.5200432444479546, "Diaphragmalgia ": 2.037056053273354, "Dizziness exertional ": 3.819390747448455, "Dizziness postural ": 7.544912524377589, "Ear pain ": 3.2423851859932724, "Eye pain ": 3.7386778630514574, "Eyelid cyst ": 2.840982603901688, "Fatigue ": 3.042111429090786, "Feeling cold ": 5.273478989088326, "Feeling of body temperature change ": 4.0782337138209375, "Fibrin D dimer increased ": 3.792462431233144, "Food aversion ": 2.65731507528003, "Forced expiratory volume increased ": 3.019958881676571, "Freezing phenomenon ": 7.947572575735706, "Grip strength ": 2.412841223328144, "Guillain-Barre syndrome ": 2.2288497602240107, "Habit cough ": 14.095700905477258, "Hangover ": 3.909260378432904, "Head lag ": 4.564915104349509, "Headache ": 4.419550032644259, "Heart rate ": 28.741196662589243, "Hemiplegic migraine ": 3.035055365627608, "Hepatic vein thrombosis ": 2.0267785406476344, "Hot flush ": 2.05211389701345, "Hyperhidrosis ": 2.775170598643258, "Hypopnoea ": 2.1231020009038053, "Illness ": 2.2854850539468843, "Immunology test ": 4.154594980138139, "Influenza ": 2.3904406625988543, "Influenza like illness ": 6.182112025594535, "Injection ": 4.504651426038966, "Injection related reaction ": 20.9037203314345, "Injection site deformation ": 2.3496774879422597, "Injection site haematoma ": 2.678747897529838, "Injection site inflammation ": 3.53590516428511, "Injection site joint erythema ": 2.198008132860444, "Injection site joint pain ": 2.3221512869589893, "Injection site joint swelling ": 3.2573999382393377, "Injection site mass ": 4.811952951021213, "Injection site pain ": 2.4085417306501555, "Injection site swelling ": 2.0514718606525166, "Injection site warmth ": 3.0707008169526326, "Instillation site warmth ": 5.130234219942129, "Ischaemic limb pain ": 2.8988850749334607, "Labyrinthitis ": 3.237443169633215, "Lacunar stroke ": 3.165761276987318, "Lethargy ": 3.247695603471658, "Limb immobilisation ": 2.1169363616894614, "Lumbar puncture ": 2.040083672172359, "Magnetic resonance imaging head ": 10.051137178476331, "Malaise ": 2.622014177443229, "Maternal exposure during breast feeding ": 7.676688074161753, "Menstruation delayed ": 2.80655562536948, "Mental fatigue ": 6.039446641253501, "Migraine ": 3.8096253557000335, "Migraine with aura ": 3.545596431366792, "Miliaria ": 4.115383950897705, "Motion sickness ": 3.0262720549873903, "Mouth cyst ": 3.784728824037096, "Muscle fatigue ": 9.133361587542094, "Myalgia ": 4.35125107258701, "Myelitis transverse ": 2.0446528978229708, "Myocardial strain imaging ": 7.037313775342047, "Nausea ": 2.5382042689332804, "Neck pain ": 2.3557841345100403, "New daily persistent headache ": 2.359385446581346, "Night sweats ": 2.557843516538353, "No reaction on previous exposure to drug ": 2.484105469062831, "Oral blood blister ": 3.211326033890387, "Oral contusion ": 2.533624472913047, "Oropharyngeal pain ": 2.3067672486762474, "Oversensing ": 4.700049216497536, "Pain in extremity ": 2.674247190492264, "Pain of skin ": 3.1204990500754066, "Paroxysmal extreme pain disorder ": 5.064751622687733, "Pelvic haemorrhage ": 3.6600657481491448, "Periarthritis ": 4.958457251061391, "Peripheral coldness ": 3.0870732450579337, "Persistent postural-perceptual dizziness ": 5.760710746971374, "Photophobia ": 2.552377572771684, "Piloerection ": 2.654475626836231, "Postmenopause ": 3.768192100120235, "Pregnancy test ": 29.767113554509702, "Primary headache associated with sexual activity ": 4.301706552270272, "Primary stabbing headache ": 12.462343133790666, "Procedural dizziness ": 6.910463954165801, "Prophylaxis of nausea and vomiting ": 13.78494150559252, "Pulmonary pain ": 2.6820752201189526, "Puncture site bruise ": 14.377338801613528, "Puncture site pain ": 2.066090346390676, "Pyrexia ": 4.326730597626697, "Q fever ": 11.21102624713178, "Radiculitis brachial ": 2.411832928514144, "Renal pain ": 3.278995172710572, "Respiratory rate ": 4.4596667087219055, "Retinal migraine ": 15.30924681327344, "SARS-CoV-2 test ": 3.259277327040506, "Sensitive skin ": 3.955656354555195, "Shoulder injury related to vaccine administration ": 3.5282621207683795, "Sight disability ": 2.3499647379914945, "Sinus headache ": 15.0152226575333, "Sinus pain ": 7.26351454259773, "Skin sensitisation ": 2.860137711692208, "Skin temperature ": 33.85643489306975, "Skin warm ": 2.413661523246591, "Splenic artery thrombosis ": 2.8840153025405595, "Splenic vein thrombosis ": 2.015084299210519, "Stiff leg syndrome ": 3.630344785372946, "Superficial vein thrombosis ": 2.2674037620261056, "Sweating fever ": 39.36730344655792, "Tenderness ": 4.954230555865419, "Tension headache ": 8.27176381159892, "Thermal burns of eye ": 2.36706499947388, "Thirst ": 2.911761147645873, "Thrombosis with thrombocytopenia syndrome ": 2.1160238036492616, "Thunderclap headache ": 4.888028137089519, "Tinnitus ": 2.1464201427422176, "Tremor ": 2.5485498019064483, "Typical aura without headache ": 3.39022668643998, "Urine output ": 12.697824195159772, "Vaccination site bruising ": 2.9013942815098024, "Vaccination site discomfort ": 2.2753532858299885, "Vaccination site infection ": 2.329395706370232, "Vaccination site inflammation ": 4.935643704645565, "Vaccination site joint erythema ": 2.458281015355784, "Vaccination site joint pain ": 2.252833548782102, "Vaccination site mass ": 4.190805210094067, "Vaccination site pain ": 2.3106827761968924, "Vaginal cyst ": 3.1231704019232844, "Vascular headache ": 12.218704716301591, "Vascular pain ": 2.788624026274165, "Vestibular migraine ": 3.306951015282894, "Viral pharyngitis ": 2.3885315379525798, "Viral rash ": 2.3061088247620534, "Visceral venous thrombosis ": 6.880848315192607, "Vomiting projectile ": 2.492063343113202, "Vulval haemorrhage ": 5.1074949117251975, "White blood cell count ": 2.364097095826074} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/301.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/301.json new file mode 100644 index 00000000000..c253602f131 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/301.json @@ -0,0 +1 @@ +{"Middle insomnia ": 160.24441423630603} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/302.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/302.json new file mode 100644 index 00000000000..d9ca941e7bd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/302.json @@ -0,0 +1 @@ +{"Aspergillus infection ": 37.95264855299348, "Blood creatinine increased ": 4.09909814621109, "Condition aggravated ": 2.567041428096967, "Death ": 8.913182427818843, "Disease progression ": 3.372544881813689, "Drug level below therapeutic ": 67.31762036114814, "Drug level increased ": 7.179809644930304, "Drug-induced liver injury ": 4.101443683140849, "Dysphagia ": 2.064852560599768, "Febrile neutropenia ": 9.188030188132352, "Fungal infection ": 9.34074022540293, "Gamma-glutamyltransferase increased ": 5.037255494651044, "Hallucination ": 2.2399277868072978, "Hepatic cytolysis ": 4.711618031890461, "Hepatic enzyme increased ": 2.8910810707256016, "Hepatotoxicity ": 6.758688786864178, "Infection ": 2.545807893418941, "Infusion site irritation ": 535.8320072993289, "Intentional product use issue ": 5.304643833263192, "Leukaemia ": 15.208481165981857, "Mucormycosis ": 52.345649742807865, "Multiple organ dysfunction syndrome ": 4.9517323139424425, "Off label use ": 8.538628319442514, "Phlebitis ": 18.152061890242305, "Product administered to patient of inappropriate age ": 27.39448415324466, "Respiratory failure ": 2.507764200291, "Severe cutaneous adverse reaction ": 2531.003005491023, "Transaminases increased ": 5.771880817934807} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/303.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/303.json new file mode 100644 index 00000000000..77ff91d7b56 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/303.json @@ -0,0 +1 @@ +{"Abdominal distension ": 3.458816071396651, "Acidosis ": 13.537338732351133, "Acute kidney injury ": 2.3162392171562285, "Alanine aminotransferase increased ": 4.02779829037874, "Amylase increased ": 19.871550489325063, "Anaemia ": 2.761178052670523, "Arterial thrombosis ": 28.06281448725047, "Aspartate aminotransferase increased ": 4.02641241691822, "Bacterial infection ": 3.544951371030247, "Bladder disorder ": 8.516030846607116, "Blood alkaline phosphatase increased ": 3.672133107400042, "Blood bilirubin increased ": 4.582089590566693, "Blood cholesterol increased ": 2.759406209726458, "Blood creatinine increased ": 5.674368572236696, "Blood lactate dehydrogenase increased ": 2.4873491159608374, "Blood lactic acid increased ": 44.87874077578777, "Blood triglycerides increased ": 15.357785872121385, "Blood urea increased ": 9.30572159573579, "Cachexia ": 9.831482652221489, "Calculus urinary ": 66.57269202135188, "Candida infection ": 2.9999920749246627, "Cardiomyopathy ": 6.105403076181301, "Conjunctivitis ": 3.1923777336566554, "Coronary artery disease ": 2.0827210679519155, "Crystalluria ": 193.18415333382933, "Dehydration ": 2.097767668797076, "Diabetes mellitus ": 10.581201166072963, "Diabetic ketoacidosis ": 3.283379577189858, "Diplopia ": 8.567519225773303, "Disseminated intravascular coagulation ": 2.632562002279617, "Drug level changed ": 124.1234648259444, "Drug resistance ": 10.394303020324488, "Dysphagia ": 2.071832252934344, "Dysuria ": 2.561658384609569, "Eyelid ptosis ": 31.305880577446903, "Fat redistribution ": 439.2645132084237, "Flank pain ": 36.12835741627367, "Gamma-glutamyltransferase increased ": 3.876819013571757, "General symptom ": 32.72172983031557, "Haematuria ": 13.637626111973487, "Haemolysis ": 5.218116735602054, "Haemolytic anaemia ": 12.136848413733292, "Haemorrhage intracranial ": 2.776626296418392, "Hepatic cirrhosis ": 4.080061379530517, "Hepatic failure ": 3.5695366402112723, "Hepatic function abnormal ": 2.962430665363821, "Hepatic steatosis ": 8.871254499605044, "Hepatitis ": 6.169405596624159, "Hepatitis cholestatic ": 5.051583375314272, "Hepatomegaly ": 4.296713476066761, "Hydronephrosis ": 74.3874413742463, "Hyperbilirubinaemia ": 21.636897229342207, "Hypercholesterolaemia ": 21.435091590214903, "Hyperglycaemia ": 4.466980246257307, "Hyperlipidaemia ": 13.585619849108884, "Hypertriglyceridaemia ": 78.43224785587607, "Immune reconstitution inflammatory syndrome ": 9.493684024709797, "Ingrowing nail ": 46.29286137177991, "Jaundice ": 5.572587602303014, "Lactic acidosis ": 13.556417406107396, "Lipase increased ": 6.302456072497876, "Lipodystrophy acquired ": 118.34258518135223, "Lipohypertrophy ": 41.87978178834146, "Lymphadenitis ": 4.164586373254649, "Maternal exposure timing unspecified ": 53.1598718254657, "Mitochondrial toxicity ": 171.58590705123788, "Multiple organ dysfunction syndrome ": 2.544399455236729, "Muscle atrophy ": 5.7329972241464535, "Myocardial infarction ": 2.7842469452972254, "Nephrolithiasis ": 108.00935272651444, "Neuropathy peripheral ": 2.899073351509041, "Ophthalmoplegia ": 21.53586652576077, "Osteoarthritis ": 3.286303745960675, "Osteonecrosis ": 2.5995832428780936, "Pancreatitis ": 6.412639307063479, "Pancreatitis acute ": 3.488385110481233, "Pancreatitis necrotising ": 16.038000960695626, "Paronychia ": 31.694505564086292, "Premature baby ": 5.249943410395293, "Progressive external ophthalmoplegia ": 317.3889860292967, "Proteinuria ": 2.752359486201103, "Pyelonephritis ": 6.738935631121545, "Renal colic ": 98.84856729281594, "Renal disorder ": 2.802216345318355, "Renal failure ": 2.749757878233725, "Renal pain ": 13.240787367702504, "Transaminases increased ": 2.010288128843992, "Tubulointerstitial nephritis ": 9.112639918945137, "Type 1 diabetes mellitus ": 4.500700291366508, "Ureterolithiasis ": 74.24484245035234} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/304.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/304.json new file mode 100644 index 00000000000..506e1de6e02 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/304.json @@ -0,0 +1 @@ +{"Acquired gene mutation ": 302.8494243972876, "Alanine aminotransferase increased ": 3.899768124345506, "Constipation ": 4.305778310152499, "Dehydration ": 4.8795956723444505, "Disease progression ": 11.146510929790148, "Drug resistance ": 25.86674604070391, "Failure to thrive ": 120.43850822071887, "Gastroenteritis ": 24.71402496274566, "Ileus ": 43.906279563289374, "Malignant neoplasm progression ": 19.025366267636603, "Metapneumovirus infection ": 604.1764313162163, "Metastases to liver ": 15.414354655152296, "Neoplasm malignant ": 7.980252722632817, "Neoplasm progression ": 13.687230092176735, "Neutropenia ": 3.0988208524026764, "Non-small cell lung cancer ": 148.72150343068327, "Oedema peripheral ": 4.112857174936864, "Orthostatic hypotension ": 26.94946694058885, "Pleural effusion ": 5.458902812646247} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/305.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/305.json new file mode 100644 index 00000000000..be3d067c1c7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/305.json @@ -0,0 +1 @@ +{"Acute generalised exanthematous pustulosis ": 5.903141674212228, "Acute kidney injury ": 4.063178829203609, "Acute respiratory distress syndrome ": 8.728420295067407, "Acute respiratory failure ": 2.9269676779482365, "Alanine aminotransferase increased ": 2.137439192012651, "Antimicrobial susceptibility test resistant ": 2551.583420968558, "Anuria ": 5.222896514313198, "Aspartate aminotransferase increased ": 3.308233065245218, "Bacteraemia ": 12.68108146363558, "Bacterial infection ": 2.224147029965766, "Blood alkaline phosphatase increased ": 4.006933761777246, "Blood creatine phosphokinase increased ": 54.64423165305575, "Blood creatinine increased ": 3.57564811076335, "C-reactive protein increased ": 2.999257276831506, "Candida infection ": 4.7311635423765965, "Cardiac valve rupture ": 458.9805810301239, "Cardiac valve vegetation ": 323.29525612114486, "Cholestasis ": 2.4078672848134346, "Clostridium difficile colitis ": 7.431467874360369, "Clostridium difficile infection ": 2.3772193634066983, "Computerised tomogram abnormal ": 20.141778659943853, "Creatinine renal clearance decreased ": 4.480271865471554, "Crepitations ": 12.116951230433182, "Cutaneous vasculitis ": 7.300895969521969, "Death ": 2.2522732678909376, "Dermatitis exfoliative generalised ": 4.468505202781701, "Device related infection ": 13.796878362177525, "Disseminated intravascular coagulation ": 5.031266931004899, "Drug eruption ": 3.2501904107130817, "Drug ineffective for unapproved indication ": 9.444749775205455, "Drug reaction with eosinophilia and systemic symptoms ": 10.73023131098096, "Drug resistance ": 11.405141995636962, "Electrocardiogram T wave amplitude decreased ": 66.05628602373844, "Embolism ": 7.065997068771261, "Endocarditis ": 54.16991503955047, "Endocarditis staphylococcal ": 303.4296897289892, "Enterococcal bacteraemia ": 195.76423322614875, "Enterococcal infection ": 45.219181603164905, "Eosinophil count increased ": 23.656250907188188, "Eosinophil percentage increased ": 47.62854443960199, "Eosinophilia ": 32.32341475709163, "Eosinophilic pneumonia ": 682.0369350743701, "Eosinophilic pneumonia acute ": 641.1133176788422, "Extradural abscess ": 43.56351430047237, "Glomerulonephritis acute ": 80.43272265657906, "Haemodialysis ": 10.059418181292155, "Henoch-Schonlein purpura ": 10.959818262048946, "Hepatic cytolysis ": 4.97017628584627, "Hyperbilirubinaemia ": 2.780444514671022, "Hyperkalaemia ": 3.0156361075387403, "Hypersensitivity pneumonitis ": 35.72259692881654, "Hyperthermia ": 3.183789971470352, "Hypertransaminasaemia ": 4.715645780029284, "Hypoxia ": 6.578677513883645, "Hypoxic-ischaemic encephalopathy ": 19.176477140611063, "Infection ": 2.5585112358098008, "International normalised ratio increased ": 2.549046171444755, "Interstitial lung disease ": 5.298761139421984, "Intervertebral discitis ": 21.184428349468572, "Leukopenia ": 2.218182652526236, "Liver function test increased ": 3.858283927757722, "Lung consolidation ": 25.89168983292649, "Lung disorder ": 4.417513773850411, "Lung infiltration ": 36.95154364665658, "Mechanical ventilation ": 9.780774841754138, "Mediastinal abscess ": 237.4138931489093, "Mental status changes ": 3.617554071226496, "Minimum inhibitory concentration ": 685.2128261388098, "Multiple organ dysfunction syndrome ": 8.244554343151947, "Myoglobin blood increased ": 14.917097126754866, "Myopathy ": 14.004946015509192, "Myositis ": 10.66438994533109, "Nephropathy toxic ": 2.8606416350262838, "Organising pneumonia ": 23.709829370286045, "Osteomyelitis ": 21.84415709602437, "Overdose ": 2.4475557792468874, "Pancytopenia ": 3.6665253818099344, "Pathogen resistance ": 54.65440177605538, "Platelet count decreased ": 2.1564889009075965, "Pleural effusion ": 2.292014885393016, "Pneumonitis ": 6.1574672326928725, "Product use in unapproved indication ": 3.8937872325232976, "Prothrombin time prolonged ": 3.18714423285526, "Pulmonary eosinophilia ": 497.9393578332279, "Pulmonary toxicity ": 6.436333795181152, "Purpura ": 2.030812692706112, "Rales ": 3.57432013906676, "Rash maculo-papular ": 2.7879823127235825, "Renal failure ": 2.4700042221524687, "Renal impairment ": 4.283992782238094, "Renal tubular necrosis ": 3.827711585342008, "Respiratory distress ": 2.5035017591251463, "Respiratory failure ": 4.524366199962117, "Rhabdomyolysis ": 29.34515103572772, "Sepsis ": 5.292201549648189, "Septic embolus ": 36.14716161049614, "Septic shock ": 6.954123828398459, "Staphylococcal bacteraemia ": 139.58746271416047, "Staphylococcal infection ": 18.17486335122408, "Staphylococcal sepsis ": 8.457407179613572, "Staphylococcus test positive ": 22.673527040134186, "Status epilepticus ": 2.0710652700024363, "Stevens-Johnson syndrome ": 5.294157804415451, "Systemic candida ": 12.551754928045783, "Systemic inflammatory response syndrome ": 8.867362060286055, "Tachypnoea ": 3.200896137197129, "Thrombocytopenia ": 2.119987646935734, "Toxic epidermal necrolysis ": 4.194768165959792, "Toxic skin eruption ": 8.553486020549041, "Treatment failure ": 4.689950787381013, "Tubulointerstitial nephritis ": 9.117199007140034, "Vancomycin infusion reaction ": 21.82925127112264, "White blood cell count increased ": 3.0048177534827345, "Wound infection staphylococcal ": 30.984574869612715} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/306.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/306.json new file mode 100644 index 00000000000..94d114bb01f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/306.json @@ -0,0 +1 @@ +{"Off label use ": 7.277038145070657, "Transaminases increased ": 73.43602230873904} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/307.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/307.json new file mode 100644 index 00000000000..28c0b3026d2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/307.json @@ -0,0 +1 @@ +{"Completed suicide ": 246.32742747638773} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/308.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/308.json new file mode 100644 index 00000000000..7cbe680ed74 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/308.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 2.5786160897649104, "Abortion spontaneous ": 2.4898774190923567, "Abulia ": 6.353675390827741, "Accidental death ": 3.24561227465808, "Activation syndrome ": 8.636184020815891, "Affect lability ": 98.92737723296162, "Affective disorder ": 2.022214791681776, "Aggression ": 3.440110293971754, "Agitation ": 15.249577262316922, "Agoraphobia ": 4.040936681818285, "Akathisia ": 3.070673060090038, "Alcohol abuse ": 2.2073722859353646, "Alcohol poisoning ": 2.505478527734472, "Alcoholism ": 2.8587493073867547, "Amnesia ": 2.027742381225784, "Anger ": 8.668178873620828, "Angle closure glaucoma ": 5.19229069199196, "Anorgasmia ": 4.295001048573446, "Anovulatory cycle ": 4.885955968575725, "Anticoagulation drug level above therapeutic ": 2.1281337990657474, "Anxiety ": 5.075860392216875, "Anxiety disorder ": 3.199838694786522, "Apathy ": 2.1630539842006167, "Arachnoid cyst ": 5.193343418404978, "Atrophy ": 2.92058461999618, "Auditory disorder ": 2.3927159187112976, "Autoinflammatory disease ": 10.511774389891716, "Bipolar I disorder ": 3.915435412024372, "Bipolar disorder ": 4.076890221810858, "Blood pressure diastolic abnormal ": 4.173067952117106, "Blood pressure diastolic decreased ": 2.4556327824897144, "Blood pressure fluctuation ": 2.1484578939372003, "Blood pressure increased ": 2.0009052009017654, "Blood pressure systolic increased ": 4.311575855696602, "Blood sodium decreased ": 2.3625331151888376, "Blood viscosity increased ": 11.110791152787844, "Body height decreased ": 2.384255670907794, "Brain herniation ": 2.65400827301843, "Bruxism ": 6.947162682775729, "Bursitis ": 2.355285992924158, "Central pain syndrome ": 16.4747193198671, "Cephalo-pelvic disproportion ": 15.580359322997642, "Cholecystectomy ": 2.531439930252384, "Claustrophobia ": 5.069822067101618, "Clonus ": 2.475582041423069, "Colitis microscopic ": 3.81520059694624, "Completed suicide ": 2.1041928351977157, "Complex regional pain syndrome ": 2.1941027618711706, "Concussion ": 3.004044136404002, "Confusional state ": 4.839952156795763, "Conversion disorder ": 3.0508665641081056, "Coordination abnormal ": 2.0035134503138297, "Costochondritis ": 2.7724146591770045, "Crying ": 4.001296338277039, "Cubital tunnel syndrome ": 18.455565138154967, "Decompression sickness ": 177.51824932240976, "Decreased interest ": 2.8800291998215943, "Decreased vibratory sense ": 4.58100827507504, "Delusion ": 2.0827037403405053, "Depressed mood ": 2.3469999876754817, "Depression ": 3.011128459136075, "Depression suicidal ": 2.578171696209027, "Depressive symptom ": 2.208728030161121, "Dermatomyositis ": 2.729272434751405, "Disinhibition ": 2.0494700878486056, "Dissociation ": 2.5603851760607035, "Disturbance in attention ": 2.700552100368536, "Dizziness ": 2.2598958094633668, "Drug interaction ": 2.024751358134939, "Drug screen positive ": 2.321065366623792, "Drug withdrawal headache ": 12.384844739571442, "Drug withdrawal syndrome ": 54.62596448720744, "Dyskinesia ": 2.348201589148452, "Dysphemia ": 2.8788059796859886, "Dysphoria ": 127.10192585752402, "Ectopic pregnancy ": 5.415282170347111, "Ejaculation disorder ": 2.3462500181350947, "Electric shock ": 6.03241675512855, "Electric shock sensation ": 77.96852408160106, "Emotional disorder ": 2.606191721056698, "Emotional poverty ": 5.28290688227006, "Essential tremor ": 8.91189143125125, "Eustachian tube dysfunction ": 4.30131504773034, "Excessive eye blinking ": 2.7490305975551106, "Exfoliative rash ": 3.0694535263777505, "Facial spasm ": 5.82919366512467, "Fall ": 2.174394521463168, "Fear ": 2.494472681394164, "Fear of injection ": 3.275201566018774, "Feeling abnormal ": 2.689952261451072, "Feeling jittery ": 2.266244409233728, "Feeling of despair ": 4.166807949135412, "Fibroadenoma of breast ": 5.000217046436411, "Fibromyalgia ": 3.344752951781586, "Fine motor skill dysfunction ": 3.0600102475698665, "Flat affect ": 3.224675324180957, "Food craving ": 2.7603563031214526, "Gastric bypass ": 16.538125688367607, "Gastrointestinal tube insertion ": 11.168888894371417, "Gastrostomy ": 4.544084198973321, "Generalised anxiety disorder ": 2.8123640446470817, "Glaucoma ": 2.682225518826126, "Glucose urine present ": 5.748010044858063, "Gluten sensitivity ": 9.200053484662345, "Growth hormone deficiency ": 9.343551457553852, "Haemoglobin increased ": 13.606265406869872, "Hallucination ": 2.638617974935465, "Hallucination, auditory ": 2.537637266925037, "Hallucination, visual ": 2.005727838390822, "Hangover ": 4.0590169440219, "Hepatic cirrhosis ": 2.14385500315432, "Hepatic steatosis ": 2.66791333686823, "High density lipoprotein increased ": 4.294792470125227, "Homicidal ideation ": 6.806799998174776, "Homicide ": 2.2442356831622914, "Hostility ": 5.5738376946590815, "Hyperhidrosis ": 4.670875436889571, "Hypermobility syndrome ": 4.413393917948008, "Hyperphagia ": 2.895506825093451, "Hyperreflexia ": 2.518730397239063, "Hypertensive crisis ": 2.5304852945390333, "Hypertonic bladder ": 4.834965793068119, "Hypervigilance ": 4.924775097611434, "Hypokinesia ": 4.018818801496984, "Hypomania ": 58.90137936013216, "Hyponatraemia ": 4.128274806220987, "Hysterectomy ": 4.823055032938819, "Impatience ": 2.9326716628786214, "Implant site extravasation ": 5.432190211167501, "Implant site swelling ": 11.140578576166847, "Impulsive behaviour ": 2.909442587366036, "Inappropriate antidiuretic hormone secretion ": 7.860906762142711, "Incoherent ": 2.408312008833648, "Increased upper airway secretion ": 2.0972793967484766, "Ingrowing nail ": 4.582940686822915, "Insomnia ": 6.038909904020921, "Intentional overdose ": 2.632084065356997, "Intentional product misuse ": 2.6433800547004966, "Intentional self-injury ": 2.070111754560939, "Investigation abnormal ": 6.315578445298536, "Irritability ": 19.78671887651882, "Ischaemic cerebral infarction ": 2.622123333564804, "Joint noise ": 21.74015705043135, "Kidney congestion ": 27.791510508102203, "Laziness ": 3.0491837077550024, "Lethargy ": 6.885095420511219, "Libido decreased ": 3.36527236295115, "Major depression ": 3.3690227382296243, "Mania ": 5.413630572116798, "Medical device site erosion ": 18.672592179462804, "Memory impairment ": 2.846944378320692, "Mental disorder ": 2.241759627222402, "Migraine without aura ": 3.623549546504935, "Mixed anxiety and depressive disorder ": 2.3462935595433465, "Moaning ": 2.68621127695474, "Mood swings ": 23.31086633979196, "Morbid thoughts ": 2.7746362247199667, "Motion sickness ": 2.0720302274388755, "Muscle atrophy ": 4.958690877021871, "Muscle spasticity ": 3.455007319817792, "Muscle tightness ": 3.067953410420849, "Muscle twitching ": 2.088657553373812, "Musculoskeletal pain ": 2.1400790250723007, "Mydriasis ": 6.213169903612969, "Myoclonus ": 2.0798824258018125, "Neck injury ": 2.0705669664758144, "Negative thoughts ": 3.512676521934172, "Nervousness ": 2.1454673488969136, "Nightmare ": 16.040272703168466, "Obsessive thoughts ": 5.034058823718284, "Ocular discomfort ": 4.1623066600193, "Ocular vascular disorder ": 3.61198627754864, "Oesophageal disorder ": 2.346630337097233, "Oesophageal spasm ": 2.8474691023159324, "Open angle glaucoma ": 4.378974673829317, "Ophthalmic vein thrombosis ": 3.824059703848672, "Orgasm abnormal ": 5.169963519201124, "Orthostatic hypotension ": 2.7953874413319744, "Osteoarthritis ": 2.554901501703663, "Panic attack ": 4.36698777095376, "Panic disorder ": 3.300305981206497, "Panic reaction ": 2.249350837383586, "Paraesthesia ": 2.7454436504055706, "Paranoia ": 3.960282633794132, "Peripheral sensorimotor neuropathy ": 2.7841462594215542, "Persistent depressive disorder ": 3.636535455816395, "Personality change ": 2.131327960116097, "Phantom limb syndrome ": 7.860610807629707, "Physical assault ": 4.566041079955316, "Pituitary tumour benign ": 3.3243704632739943, "Placenta praevia ": 4.30131504773034, "Post-traumatic stress disorder ": 2.88483184122589, "Postoperative wound infection ": 2.927893806217169, "Potentiating drug interaction ": 3.570557902202204, "Prescribed overdose ": 2.884757437136783, "Psychogenic seizure ": 4.744806210036919, "Psychomotor hyperactivity ": 2.233385698802848, "Psychotic behaviour ": 2.699021846482917, "Pulmonary valve disease ": 28.8072066431291, "Reflexes abnormal ": 3.082568224084912, "Respiratory disorder neonatal ": 4.110690737252869, "Restless legs syndrome ": 3.075314982114855, "Restlessness ": 2.3646762507507044, "Rotator cuff syndrome ": 7.0658430004860495, "Salpingo-oophorectomy bilateral ": 56.50052127117235, "Scoliosis ": 10.161214654811335, "Seizure ": 2.253498713015853, "Self-destructive behaviour ": 4.050658288133336, "Self-injurious ideation ": 4.199279031616839, "Sensory disturbance ": 23.245802368493333, "Serotonin syndrome ": 18.65622994284165, "Sexual dysfunction ": 2.575726776579052, "Skin abrasion ": 2.192138576713639, "Skin laceration ": 3.4797844061269347, "Sleep deficit ": 2.844849661934622, "Sleep disorder ": 6.18770538779633, "Sleep talking ": 6.699704772098174, "Slow response to stimuli ": 2.006422507084177, "Snoring ": 3.43730149302737, "Social anxiety disorder ": 3.031544647647328, "Social avoidant behaviour ": 2.907042681504529, "Somatic symptom disorder ": 3.0790059857478966, "Somnambulism ": 2.928567944773277, "Sopor ": 2.0453293868930724, "Spinal fusion surgery ": 3.654433603404952, "Staring ": 2.357840608975428, "Suicidal behaviour ": 7.516592005680359, "Suicidal ideation ": 18.566736610768658, "Suicide attempt ": 7.225240397195066, "Systolic hypertension ": 3.3053713182837003, "Tachyphrenia ": 8.360011212844997, "Tardive dyskinesia ": 2.168629695426599, "Tendonitis ": 2.7339527060204096, "Thinking abnormal ": 3.738123581127328, "Tinnitus ": 4.130101106715045, "Tongue biting ": 2.072344799307741, "Transposition of the great vessels ": 3.658687899244266, "Tremor ": 3.55451544536296, "Ulnar nerve injury ": 10.630785699264049, "Urinary hesitation ": 5.018323696603995, "Urinary retention ": 2.358118189033612, "Urinary tract infection bacterial ": 5.474852993934862, "Uterine disorder ": 5.139953658140763, "Ventricular hypoplasia ": 12.47745812141054, "Vertigo ": 8.233718075081516, "Violence-related symptom ": 2.8368665638548527, "Viraemia ": 4.337558439054439, "Vitamin D decreased ": 2.991942822434851, "Weight increased ": 2.9705141682593785, "Withdrawal syndrome ": 9.560767610940456, "Wrong patient received product ": 2.037818023336037, "Yawning ": 4.72685073686399} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/309.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/309.json new file mode 100644 index 00000000000..9598a7dd19d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/309.json @@ -0,0 +1 @@ +{"Decreased appetite ": 2.1413946943176327, "Febrile neutropenia ": 33.47390484485422, "Hypertension ": 2.5248762972605103, "Interstitial lung disease ": 23.18550861369721, "Malignant neoplasm progression ": 30.20567096301881, "Nephrotic syndrome ": 54.95641009513694, "Neutropenia ": 3.851629025383612, "Neutrophil count decreased ": 41.06082429510501, "Platelet count decreased ": 5.210490175613992, "Proteinuria ": 21.88696057678864} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/31.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/31.json new file mode 100644 index 00000000000..2ab1d84f649 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/31.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 4.95455483802973, "Acute respiratory distress syndrome ": 15.33633069742082, "Agranulocytosis ": 6.932698091959746, "B-cell lymphoma ": 71.8739148565652, "Blood creatinine increased ": 4.2624158150112335, "COVID-19 pneumonia ": 17.890807725906352, "Confusional state ": 2.001633942195321, "Cytomegalovirus infection ": 18.197586265690884, "Death ": 2.763138541139967, "Diabetes mellitus ": 2.8074198527320195, "Diarrhoea ": 2.29093532676425, "Drug interaction ": 5.437171778323573, "Foetal growth restriction ": 29.98462593332849, "General physical health deterioration ": 2.374009487131179, "Hallucination ": 2.718963281340096, "Hyperkalaemia ": 2.963279342738166, "Immunosuppressant drug level decreased ": 139.8358572904043, "Immunosuppressant drug level increased ": 203.18370510793835, "Kidney transplant rejection ": 45.82340584018013, "Leukopenia ": 5.17567030453581, "Multiple organ dysfunction syndrome ": 7.873443172391126, "Neutropenia ": 4.757569884751916, "Pancreatitis acute ": 8.633271691888433, "Pancytopenia ": 5.262442904968156, "Pyelonephritis ": 24.124508803547105, "Sepsis ": 2.5709070448682443, "Thrombocytopenia ": 2.723217135192942, "Transplant rejection ": 51.16259280811333} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/310.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/310.json new file mode 100644 index 00000000000..9b1d5b4b1cf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/310.json @@ -0,0 +1 @@ +{"Abdominal compartment syndrome ": 15.57604961825209, "Abdominal infection ": 10.285658777435517, "Abdominal mass ": 6.648450219714082, "Abdominal tenderness ": 3.6750197177021184, "Activated partial thromboplastin time prolonged ": 3.438429960056684, "Acute cholecystitis necrotic ": 22.86089195551355, "Acute graft versus host disease ": 3.587126836832636, "Acute graft versus host disease in intestine ": 5.789035605391401, "Acute graft versus host disease in liver ": 11.880416269822566, "Acute graft versus host disease in skin ": 7.730972200496694, "Acute leukaemia ": 7.054406070085901, "Acute lymphocytic leukaemia ": 23.18504132189374, "Acute lymphocytic leukaemia recurrent ": 54.58684806722853, "Acute lymphocytic leukaemia refractory ": 133.8200401887634, "Acute myeloid leukaemia ": 18.521110045737835, "Acute myeloid leukaemia recurrent ": 154.0440395667228, "Acute promyelocytic leukaemia ": 13.900643101419472, "Acute respiratory distress syndrome ": 3.0476904407998053, "Acute respiratory failure ": 2.396873713587975, "Adenovirus infection ": 11.417995204227672, "Agranulocytosis ": 2.4646868362278846, "Alanine aminotransferase increased ": 2.4100306900599446, "Allogenic stem cell transplantation ": 25.408759514637143, "Alpha haemolytic streptococcal infection ": 47.05986632481543, "Aplastic anaemia ": 2.7634868926917022, "Appendicitis ": 3.660852485868422, "Ascites ": 2.2716440856686604, "Aspergillus infection ": 15.935425382432026, "Atelectasis ": 5.2362575992736815, "Atypical pneumonia ": 3.7276568503251672, "Axonal neuropathy ": 14.49784258602676, "B precursor type acute leukaemia ": 57.5122810435514, "B-cell lymphoma ": 3.7692094783503536, "B-cell lymphoma recurrent ": 56.52921272730367, "B-cell lymphoma refractory ": 112.08803591853076, "BK virus infection ": 8.457186047866314, "Bacteraemia ": 13.95244220028158, "Bacterial infection ": 11.848162457428147, "Bacterial sepsis ": 14.25766666869462, "Bipolar I disorder ": 9.40081124182709, "Blast cells present ": 29.330349030159496, "Blast crisis in myelogenous leukaemia ": 11.018826704935348, "Blood HIV RNA increased ": 17.218419021522823, "Blood bilirubin increased ": 3.3476088037624203, "Blood bilirubin unconjugated increased ": 12.071573834927326, "Blood culture positive ": 20.62004837738728, "Blood disorder ": 6.377455557356458, "Blood fibrinogen decreased ": 13.54617772855821, "Blood immunoglobulin A decreased ": 22.53023608901824, "Blood immunoglobulin G decreased ": 6.98489893239978, "Blood lactate dehydrogenase increased ": 8.172529681973671, "Blood lactic acid increased ": 3.445692605092733, "Bone marrow disorder ": 4.96426837717329, "Bone marrow failure ": 16.592443737939597, "Brain abscess ": 6.997565443782843, "Bronchopulmonary aspergillosis ": 15.747438688597022, "Burkitt's lymphoma ": 30.92677999308082, "Caesarean section ": 2.094640100912001, "Candida infection ": 6.608983697144195, "Candida sepsis ": 27.2784983733701, "Cardiac dysfunction ": 3.820968920288356, "Cardiac tamponade ": 3.167779705095913, "Cardiomyopathy ": 4.113149728952029, "Cardiotoxicity ": 8.865183445218223, "Catheter site erythema ": 6.249086575690802, "Catheter site pain ": 7.261041774239043, "Central nervous system infection ": 17.78686887311397, "Central nervous system lesion ": 2.580033639044916, "Central nervous system leukaemia ": 35.37615033599663, "Central nervous system lymphoma ": 80.22808013371929, "Central sleep apnoea syndrome ": 22.8904238492737, "Cerebral venous thrombosis ": 3.742591659437725, "Chest injury ": 6.263185677137105, "Chest wall mass ": 45.65588686346895, "Chloroma ": 35.535503929416336, "Cholecystitis ": 2.444960130502968, "Cholecystitis acute ": 3.176263728869182, "Chronic graft versus host disease ": 4.380936863763312, "Chronic lymphocytic leukaemia ": 3.991357663434518, "Chronic myeloid leukaemia ": 3.415735213168298, "Chronic sinusitis ": 3.443327558982505, "Clostridium difficile colitis ": 7.351137413831356, "Clostridium difficile infection ": 5.763065910988553, "Clostridium test positive ": 6.583859114937175, "Coagulopathy ": 3.193760208366643, "Colitis ": 4.273945618878503, "Complication associated with device ": 2.380440390420163, "Computerised tomogram abnormal ": 8.585450407730658, "Congenital aplasia ": 15.793214999759323, "Cystitis haemorrhagic ": 8.201168753931636, "Cytogenetic abnormality ": 16.441332592410845, "Cytogenetic analysis abnormal ": 7.301649011767729, "Cytokine release syndrome ": 4.605035216977831, "Cytomegalovirus chorioretinitis ": 19.10429481247694, "Cytomegalovirus infection ": 4.791314898670538, "Cytomegalovirus infection reactivation ": 9.58301553449448, "Cytomegalovirus viraemia ": 4.87524639858387, "Cytopenia ": 16.663481171374332, "Delivery ": 35.55598148693523, "Device related infection ": 3.0422651673140653, "Differentiation syndrome ": 38.50325125929505, "Diffuse large B-cell lymphoma ": 33.22414470690555, "Diffuse large B-cell lymphoma recurrent ": 109.84257728385565, "Diffuse large B-cell lymphoma refractory ": 114.89787607503868, "Disease complication ": 6.312276635523843, "Disease progression ": 12.715959300338916, "Disease recurrence ": 5.520821180831333, "Disseminated intravascular coagulation ": 3.660186505386039, "Drug resistance ": 3.6682188262294138, "Drug-induced liver injury ": 2.026401104778914, "Duodenal obstruction ": 35.94525437583702, "Encephalitis ": 4.314287024392828, "Encephalopathy ": 3.1851358349031726, "Engraftment syndrome ": 16.921972193368926, "Enteritis ": 4.548323001829614, "Enterobacter infection ": 61.83884298708227, "Enterococcal infection ": 8.532661766741862, "Enterococcus test positive ": 50.97053886214012, "Enterocolitis infectious ": 46.37593003976208, "Enterovirus infection ": 116.68565047832332, "Epstein-Barr virus infection ": 3.4555301212070413, "Escherichia bacteraemia ": 25.142345185944997, "Escherichia infection ": 14.761084256156671, "Escherichia sepsis ": 13.254884277002946, "Febrile bone marrow aplasia ": 16.05022267978736, "Febrile neutropenia ": 45.81071324906084, "Foetal anaemia ": 107.95678939511905, "Foetal growth restriction ": 2.3008489458749604, "Follicular lymphoma ": 29.339581089205733, "Full blood count decreased ": 2.756190249461182, "Fungaemia ": 32.423125896178675, "Fungal infection ": 6.771285987602036, "Fusarium infection ": 28.046526531043806, "Gallbladder enlargement ": 11.8698628159706, "Gastroenteritis norovirus ": 13.611437944761864, "Gastrointestinal inflammation ": 8.352669647091659, "Gastrointestinal toxicity ": 3.6019455128828524, "Gastrointestinal wall thickening ": 10.942681602711453, "Gene mutation ": 7.588635848261394, "Geotrichum infection ": 181.16345793633465, "Graft versus host disease ": 5.862931451392072, "Graft versus host disease in gastrointestinal tract ": 14.277123102281712, "Graft versus host disease in skin ": 9.656865195379297, "Granulocyte count decreased ": 8.331078621858817, "Granulocytopenia ": 7.421318138289921, "Haematotoxicity ": 8.532628794068346, "Haemodynamic instability ": 2.787054549417832, "Haemoglobin abnormal ": 21.192435046281325, "Haemoglobin decreased ": 3.648627479500718, "Haemophagocytic lymphohistiocytosis ": 9.633523333615232, "Hepatic lesion ": 3.3495688838688578, "Hepatic steatosis ": 2.2874937092487726, "Hepatitis B ": 5.271113976880163, "Hepatitis B reactivation ": 6.873191511730263, "Hepatomegaly ": 4.042389901088626, "Hepatosplenomegaly ": 4.6136682945475656, "Herpes simplex ": 5.380678817899063, "Hodgkin's disease ": 8.940471354094425, "Human bocavirus infection ": 63.03107189827492, "Human herpesvirus 6 infection ": 37.11896797527905, "Human herpesvirus 6 infection reactivation ": 26.09731633108, "Human herpesvirus 8 infection ": 32.49040592248048, "Hydronephrosis ": 2.346505604908505, "Hyperbilirubinaemia ": 8.00340091620727, "Hyperlipidaemia ": 2.0138679805726807, "Hypertransaminasaemia ": 3.7709309891317626, "Hypertriglyceridaemia ": 2.975052763041889, "Hypervolaemia ": 3.5097280343200747, "Hypoalbuminaemia ": 5.501123724480826, "Hypogammaglobulinaemia ": 29.900991162195343, "Hypogonadism ": 7.301649011767729, "Hypophagia ": 2.546276862235616, "Hypoxia ": 3.356690480536494, "Ileus ": 2.274358284995789, "Immune effector cell-associated neurotoxicity syndrome ": 5.067830109690039, "Immunodeficiency ": 2.117381157705677, "Immunosuppression ": 3.823556269592133, "Inappropriate antidiuretic hormone secretion ": 2.17238025138904, "Infection ": 4.226800370417621, "Infection in an immunocompromised host ": 57.770230171665865, "Inflammatory marker increased ": 4.390950891122365, "Intestinal perforation ": 3.5843806823334226, "Intra-abdominal haemorrhage ": 3.026902710183785, "Keratitis ": 4.042691824278513, "Klebsiella infection ": 13.35309864921058, "Klebsiella sepsis ": 22.266361062781044, "Laryngospasm ": 2.435335974190288, "Leukaemia ": 3.5443285638424578, "Leukaemia recurrent ": 28.267523141071106, "Leukocytosis ": 2.2877321042925938, "Leukoencephalopathy ": 15.70552442011438, "Leukopenia ": 2.5239899560495758, "Liver abscess ": 5.575072098749756, "Low birth weight baby ": 2.1407826356628017, "Lung consolidation ": 8.2002024625787, "Lung infiltration ": 2.60844876134563, "Lung opacity ": 6.036730017482625, "Lymphadenopathy mediastinal ": 4.695930233122192, "Lymphocyte count decreased ": 4.575501663910246, "Lymphocyte count increased ": 4.368453748466752, "Lymphoma ": 5.557509956389152, "Lymphopenia ": 2.077239725416044, "Malignant neoplasm progression ": 2.149678733019357, "Mantle cell lymphoma ": 31.931146453856304, "Mantle cell lymphoma recurrent ": 86.48253246507716, "Metastases to spleen ": 17.512252148486507, "Metastasis ": 2.3328121215426005, "Methaemoglobinaemia ": 14.07186529698887, "Minimal residual disease ": 33.544187395813935, "Mucormycosis ": 34.97631926772645, "Mucosal inflammation ": 15.740472236651442, "Multiple organ dysfunction syndrome ": 6.739153860369067, "Myelodysplastic syndrome ": 16.599059698990477, "Myelopathy ": 15.337413912491414, "Myelosuppression ": 20.35230207004287, "Necrosis ": 2.7619128609137733, "Neoplasm ": 2.602491106837406, "Neoplasm progression ": 2.495175503653735, "Neoplasm recurrence ": 18.0973582551348, "Nervous system disorder ": 2.6596998601594053, "Neurological decompensation ": 6.556559817281046, "Neuropathy peripheral ": 2.2718883026276244, "Neurotoxicity ": 5.400012623858544, "Neutropenia ": 5.314259646054684, "Neutropenic colitis ": 30.74581354202947, "Neutropenic infection ": 68.21820345943779, "Neutropenic sepsis ": 21.44495738479297, "Neutrophil count decreased ": 6.158538051637303, "Neutrophil count increased ": 2.6854346104900038, "Nodule ": 2.241301870784812, "Non-Hodgkin's lymphoma ": 7.635581201386291, "Non-Hodgkin's lymphoma recurrent ": 21.526101970521967, "Non-cardiac chest pain ": 10.769057248873136, "Norovirus test positive ": 23.799004635289663, "Obstructive sleep apnoea syndrome ": 2.724315726997285, "Off label use ": 3.0805570161282603, "Oral disorder ": 3.194451962349238, "Oral herpes ": 2.2722103677390884, "Organising pneumonia ": 2.5397925576383256, "Otitis media ": 2.909983131892154, "Pancytopenia ": 9.118206841572222, "Parainfluenzae virus infection ": 73.19461253797118, "Paraplegia ": 3.64482324948938, "Paronychia ": 4.426790638793492, "Pathogen resistance ": 4.700790345025746, "Pericoronitis ": 200.66396200307184, "Peripheral sensory neuropathy ": 6.633860156241059, "Platelet count abnormal ": 3.861330290451181, "Platelet count decreased ": 4.13457885030131, "Platelet count increased ": 2.2922483742357858, "Pleural effusion ": 3.425071193535427, "Pneumatosis intestinalis ": 16.22595817284289, "Pneumocystis jirovecii infection ": 14.945647142137853, "Pneumocystis jirovecii pneumonia ": 4.394982201765128, "Pneumonia cytomegaloviral ": 11.1639430085824, "Pneumonia fungal ": 24.842092675096893, "Pneumonia klebsiella ": 9.477767992865791, "Pneumonia necrotising ": 20.861977227008, "Pneumonia viral ": 4.427158217358356, "Post transplant lymphoproliferative disorder ": 3.5347068757922746, "Posterior reversible encephalopathy syndrome ": 12.250743157607856, "Premature delivery ": 12.853060264706691, "Procalcitonin increased ": 7.938607581413303, "Proctalgia ": 4.743904605819446, "Product use in unapproved indication ": 3.349528077700504, "Progressive multifocal leukoencephalopathy ": 5.10487787093283, "Pseudomonal sepsis ": 17.012471858250922, "Pseudomonas infection ": 12.371061814410146, "Pulmonary alveolar haemorrhage ": 2.0754669119067217, "Pulmonary haemorrhage ": 5.385205252880625, "Pulmonary mass ": 3.13730654094062, "Pulse absent ": 3.5795845893407408, "Pyomyositis ": 44.54872015749093, "Quadriparesis ": 4.3491671698186, "Recurrent cancer ": 4.344231902568605, "Refractory cancer ": 133.0906916254109, "Respiratory failure ": 3.310603810587456, "Respiratory syncytial virus infection ": 2.9732110193388244, "Rhinovirus infection ": 49.558251283999525, "Richter's syndrome ": 14.632347746663056, "Scedosporium infection ": 17.332703644595487, "Second primary malignancy ": 11.658445398650723, "Secondary immunodeficiency ": 29.495923097894487, "Sepsis ": 6.953581040441766, "Septic shock ": 12.912999659606957, "Serum ferritin increased ": 3.108025899253904, "Shock ": 2.0512098708896658, "Sialoadenitis ": 9.264159808038096, "Sinus tachycardia ": 4.523188940875042, "Sinusitis fungal ": 21.267871927788896, "Skin abrasion ": 3.16818893193674, "Skin infection ": 2.941933707968871, "Skin lesion ": 2.172306088148208, "Skin mass ": 3.671883340394436, "Skin toxicity ": 4.136057648139247, "Small for dates baby ": 3.360853853354893, "Small intestinal obstruction ": 3.0910296837717315, "Splenomegaly ": 3.441761004046104, "Staphylococcal bacteraemia ": 12.256940557521672, "Staphylococcal infection ": 4.552520600362821, "Staphylococcal sepsis ": 9.32876394480068, "Staphylococcus test positive ": 6.9257335106474125, "Stenotrophomonas infection ": 33.09178063487313, "Stillbirth ": 2.4237329318908407, "Stomatitis ": 2.975252445554612, "Streptococcal bacteraemia ": 34.90311658194775, "Streptococcal sepsis ": 24.48153756135591, "Subdural haemorrhage ": 2.442995380310994, "Systemic candida ": 16.958757636291455, "Systemic inflammatory response syndrome ": 3.004391599369833, "Systemic mycosis ": 11.018346918548264, "T-cell type acute leukaemia ": 53.02214639499286, "Therapeutic response decreased ": 2.071291989921132, "Therapy non-responder ": 4.496792943266767, "Therapy partial responder ": 7.576436500916198, "Thrombocytopenia ": 3.9602233097795576, "Tooth infection ": 4.400446714301371, "Total lung capacity decreased ": 7.008477902584493, "Trichosporon infection ": 48.17872143441225, "Tumour lysis syndrome ": 14.06014717213332, "Upper respiratory tract infection ": 2.310943791498685, "Vancomycin infusion reaction ": 5.785532944490518, "Varicella zoster virus infection ": 6.7404349733585445, "Vascular access complication ": 39.89214261637929, "Venoocclusive disease ": 12.064854536810708, "Venoocclusive liver disease ": 19.927056216908294, "Venous thrombosis ": 5.628463872028836, "Viraemia ": 18.039951093088472, "Viral infection ": 2.0753429258254905, "White blood cell count abnormal ": 6.951199444951618, "White blood cell count decreased ": 3.771167868541916, "White matter lesion ": 46.76206415659838} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/311.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/311.json new file mode 100644 index 00000000000..4ee07a48045 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/311.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 3.2959360786638765, "Atrial fibrillation ": 4.931400790226213, "Bradycardia ": 7.710796698915945, "Cerebrovascular accident ": 3.64274916671208, "Drug interaction ": 11.200062245279208, "Erythema multiforme ": 27.12061159193146, "Gastrointestinal haemorrhage ": 21.000419612953703, "Hypotension ": 3.36307978422681, "Rectal haemorrhage ": 11.599419205452095, "Treatment failure ": 6.931379670745067} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/312.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/312.json new file mode 100644 index 00000000000..816253544e7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/312.json @@ -0,0 +1 @@ +{"Anaplastic thyroid cancer ": 1006.3657503455536, "BRAF V600E mutation positive ": 1004.5702561249988, "Blood creatine phosphokinase increased ": 5.361261175640397, "Blood lactate dehydrogenase increased ": 6.416465175399551, "Blood test abnormal ": 9.799284165527297, "C-reactive protein increased ": 2.9745741184208128, "Cognitive disorder ": 2.78332873890958, "Colitis ": 2.4084367606706825, "Dermatitis acneiform ": 14.005125160685402, "Disease progression ": 3.3771378019265934, "Disease recurrence ": 2.3186438956629987, "Drug reaction with eosinophilia and systemic symptoms ": 3.6043146061928, "Drug resistance ": 8.563251101083688, "Dysphagia ": 2.5750605699166345, "Ejection fraction decreased ": 28.59351053125258, "Erythema nodosum ": 15.347927069937317, "Fear ": 4.666537695235013, "Haemophagocytic lymphohistiocytosis ": 14.5978623926523, "Hepatitis ": 2.43402874286642, "Hepatotoxicity ": 2.916078764798514, "Hyperpyrexia ": 4.713689506436015, "Hyperthyroidism ": 2.1316720979895387, "Intentional product use issue ": 2.141262215847849, "Liver function test increased ": 2.319048612076317, "Lung adenocarcinoma ": 25.76589602633331, "Malignant melanoma ": 62.77887682052799, "Malignant melanoma stage IV ": 110.14107887544486, "Malignant neoplasm progression ": 33.366863067596874, "Melanoma recurrent ": 101.38713681701633, "Metastases to bone ": 10.48483944623639, "Metastases to central nervous system ": 74.25310461855811, "Metastases to liver ": 13.449048807140931, "Metastases to lung ": 26.540211495558733, "Metastases to lymph nodes ": 30.70553947850328, "Metastases to meninges ": 59.98765145654069, "Metastases to skin ": 77.26958700981854, "Metastasis ": 11.510920545905874, "Metastatic malignant melanoma ": 398.4923391902726, "Mucosal inflammation ": 6.212920658691106, "Neoplasm ": 9.161247639507623, "Neoplasm progression ": 2.573619239728883, "Neutropenia ": 3.1551653707704035, "Non-small cell lung cancer ": 13.876856684339211, "Oesophagitis ": 10.19261524565018, "Panniculitis ": 33.217689177885575, "Pemphigoid ": 4.396866657824431, "Peripheral motor neuropathy ": 45.268081504696575, "Peripheral sensory neuropathy ": 10.448255366274385, "Pneumonitis ": 8.993253828545377, "Polyneuropathy ": 4.975738969265043, "Product use in unapproved indication ": 5.758747823023028, "Pulmonary mass ": 6.528449299665128, "Pyrexia ": 2.48585847194192, "Rhabdomyolysis ": 2.4133314712281444, "Sarcoidosis ": 11.07554627931574, "Skin toxicity ": 23.845245938097648, "Therapeutic response decreased ": 6.037042566921579, "Therapy partial responder ": 40.26413926134357, "Uveitis ": 35.17084728831189} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/313.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/313.json new file mode 100644 index 00000000000..66dfe300739 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/313.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 2.321318364335335, "Anaemia ": 3.8876991939893264, "Anuria ": 10.4227031742893, "Ascites ": 15.145343648683788, "Aspartate aminotransferase increased ": 3.347161770117708, "Blindness ": 2.910394317097917, "Blood bilirubin increased ": 4.212472746770841, "Blood pressure decreased ": 2.5939334539815757, "Bradycardia ": 3.49247399722273, "Cachexia ": 24.54439833452568, "Chronic hepatitis C ": 153.81904732081443, "Drug ineffective ": 12.037632053050023, "Drug interaction ": 3.134264434079593, "Drug resistance ": 3.4354189144129426, "Duodenitis ": 42.56792082718861, "Encephalopathy ": 9.29907867292176, "Foot fracture ": 6.381036602960899, "Gamma-glutamyltransferase increased ": 4.354495610237676, "Gastritis ": 5.466515698962911, "Genotype drug resistance test positive ": 605.38686445476, "HIV infection ": 94.41371560596392, "Hepatic cancer ": 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/314.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/314.json new file mode 100644 index 00000000000..81311a698c1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/314.json @@ -0,0 +1 @@ +{"Acne ": 136.8127877847876, "Alopecia ": 24.773519376552883, "Condition aggravated ": 13.027889767419628, "Drug ineffective ": 4.108829562545642, "Incorrect route of product administration ": 48.17924502154337, "Liver function test abnormal ": 88.08209458992357, "Loss of personal independence in daily activities ": 31.3291419328828, "Ovarian cyst ": 621.1673489199251, "Overdose ": 15.257887090500232, "Pain ": 4.513551486942567, "Pneumonia ": 12.520733498148957, "Product use issue ": 14.312856635970098, "Rheumatoid arthritis ": 23.24494276485305, "Sleep disorder due to general medical condition, insomnia type ": 415.4554398077158, "Transplant dysfunction ": 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/316.json new file mode 100644 index 00000000000..c7f552db59d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/316.json @@ -0,0 +1 @@ +{"Blood pressure increased ": 5.248971730957916, "Dizziness ": 2.4752661277959533, "Oedema peripheral ": 6.525972831883817, "Wrong technique in product usage process ": 13.0030641247141} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/317.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/317.json new file mode 100644 index 00000000000..f94b2c97fd2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/317.json @@ -0,0 +1 @@ +{"Anaemia ": 3.625522089039976, "Ascites ": 4.298027711624499, "Bradycardia ": 2.1425306527845995, "Cardiac failure ": 2.567011987479085, "Delusion ": 5.2476077109873644, "Disturbance in attention ": 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4.355902856228382, "Oesophageal varices haemorrhage ": 31.465047549163856, "Psychotic disorder ": 4.714687668640631, "Pulmonary arterial hypertension ": 13.100647152090543, "Septic shock ": 3.760529087791993, "Speech disorder ": 2.367067336722572, "Surgery ": 4.2862405217937285, "Therapy non-responder ": 3.9449106387315753, "Treatment failure ": 65.28348799198957, "Treatment noncompliance ": 3.1361711498141025, "Viral load increased ": 12.881783917569264, "Viral mutation identified ": 77.95247564998206, "Virologic failure ": 30.535854944315773} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/318.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/318.json new file mode 100644 index 00000000000..e7df3f884e4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/318.json @@ -0,0 +1 @@ +{"Arrhythmia ": 3.787587708056783, "Arterial occlusive disease ": 42.69625338462652, "Bronchitis ": 15.328287056032352, "Chronic obstructive pulmonary disease ": 48.60039458391499, "Dyspnoea ": 4.021099705085336, "Haemorrhage ": 2.949708418686076, "Heart rate increased ": 4.839791328308693, "Illness ": 7.168633491688431, "Intentional product misuse ": 8.952161062495813, "Off label use ": 2.064449570085352, "Pneumonia ": 5.551312507713237, "Product dose omission issue ": 7.461581735497777, "Tremor ": 3.217502171068173, "Weight decreased ": 3.316367341468318} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/319.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/319.json new file mode 100644 index 00000000000..758bff89256 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/319.json @@ -0,0 +1 @@ +{"Abdominal distension ": 4.480299620257311, "Acute kidney injury ": 3.442823079862193, "Acute myocardial infarction ": 8.230450875353094, "Altered state of 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/32.json @@ -0,0 +1 @@ +{"Anti factor VIII antibody increased ": 1504.9310023749174, "Anti factor VIII antibody positive ": 709.2331216936611, "Anti factor VIII antibody test ": 1794.795778416135, "Cerebral haemorrhage ": 3.8508492116380815, "Contusion ": 6.771531811078156, "Extra dose administered ": 46.93094278082483, "Factor VIII inhibition ": 7454.559016309977, "Fall ": 3.152567935687556, "Haemarthrosis ": 667.7554723400546, "Haematemesis ": 3.758937820757549, "Haematoma ": 11.980213383208149, "Haematoma muscle ": 23.95071289970571, "Haematuria ": 2.94461079396561, "Haemorrhage ": 48.52981161493238, "Haemorrhage intracranial ": 9.704736643486026, "Haemorrhage subcutaneous ": 9.736029390613254, "Head injury ": 11.662746173364592, "Inhibiting antibodies ": 3940.9703485076943, "Inhibiting antibodies positive ": 1497.021142300464, "Injury ": 4.187367198535719, "Joint injury ": 24.11801714283509, "Joint swelling ": 3.1137597639486088, "Limb injury ": 20.54735479041749, "Mouth haemorrhage ": 34.60356212098903, "Muscle haemorrhage ": 168.5913638164659, "Road traffic accident ": 4.55197166552746, "Therapeutic product effect decreased ": 2.1669892705539557, "Vascular device infection ": 47.4278604348247} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/320.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/320.json new file mode 100644 index 00000000000..5a3035436a4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/320.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 3.003182037754114, "Altered state of consciousness ": 5.509876812962887, "Antimicrobial susceptibility test resistant ": 1146.818714423247, "Arthritis bacterial ": 61.70225519680322, "Blood creatine phosphokinase increased ": 7.132789688702759, "C-reactive protein increased ": 2.576513694743252, "Candida infection ": 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30.46158083737492} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/321.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/321.json new file mode 100644 index 00000000000..5b43281b6d9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/321.json @@ -0,0 +1 @@ +{"Anaemia ": 4.734585531815524, "Aplastic anaemia ": 23.13578027934807, "Atrial fibrillation ": 3.092356399071226, "Bone pain ": 3.891300656337952, "Cardiac failure ": 2.293701102514334, "Cytomegalovirus infection reactivation ": 43.90331700365943, "Deep vein thrombosis ": 2.0410990548424874, "Febrile neutropenia ": 7.012886842356283, "Haematotoxicity ": 27.306766249685985, "Intentional product use issue ": 2.985059149369655, "Lethargy ": 5.012191801092992, "Localised infection ": 28.256979611010827, "Lower respiratory tract infection ": 7.665860095136718, "Myelosuppression ": 2.0854331433781645, "Neuropathy 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00000000000..6adb87d4e8b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/322.json @@ -0,0 +1 @@ +{"Abdominal distension ": 19.936035137679664, "Abdominal pain ": 5.28044169436573, "Anaemia ": 5.072805980722283, "Analgesic therapy ": 505.3676511870972, "Aplasia pure red cell ": 26.41592018628307, "Appendicitis ": 141.54596667567208, "Appendicolith ": 482.6031003037765, "Ascites ": 45.03706912035207, "Bacterial infection ": 53.175941204490975, "Blood cholesterol increased ": 15.308342187836574, "Blood phosphorus increased ": 230.84390741085903, "Blood uric acid increased ": 80.88319461086844, "Cardiogenic shock ": 89.32334810185446, "Condition aggravated ": 4.316333227440547, "Constipation ": 10.923261731872126, "Diabetes mellitus ": 11.719148574124294, "Drug hypersensitivity ": 2.510450706629234, "Drug therapy ": 1909.175898647532, "Dry mouth ": 11.177851954948514, "Foetal exposure during pregnancy ": 3.572086143289717, "General physical health 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8.606587403070778, "Abortion spontaneous ": 3.973337641069544, "Acute kidney injury ": 2.184662463410167, "Adverse drug reaction ": 2.4703017974985664, "Ascites ": 3.265958140037682, "Benign prostatic hyperplasia ": 23.93434226255876, "Blood HIV RNA increased ": 112.31137603770236, "Blood alkaline phosphatase increased ": 2.0225237737088406, "Blood cholesterol increased ": 5.447698231408759, "Blood triglycerides increased ": 25.94930043054709, "Brain stem stroke ": 164.40142667332285, "CD4 lymphocytes decreased ": 52.85833010000207, "Cachexia ": 12.888059821691806, "Caesarean section ": 9.07706023739452, "Cerebral ventricle dilatation ": 85.94795592095674, "Congenital musculoskeletal disorder of skull ": 103.1479389574201, "Cushing's syndrome ": 19.14370275938481, "Drug interaction ": 6.590953689055403, "Drug resistance ": 18.23457458881037, "Duodenal ulcer ": 24.3667078257071, "Dyslipidaemia ": 9.211546746419312, "Exposure during pregnancy ": 8.258474821800872, "Foetal death ": 11.485077943161643, "Foetal exposure during pregnancy ": 9.174438520940107, "Foot fracture ": 3.751483312827532, "Gastric ulcer ": 8.859596542922949, "Gene mutation ": 57.87411781017406, "Genotype drug resistance test positive ": 38.93701901365275, "HIV infection ": 49.13240810702784, "HIV viraemia ": 657.6699485594878, "Hepatic cancer ": 9.530161096996478, "Hepatitis cholestatic ": 11.794282110757702, "Human immunodeficiency virus transmission ": 502.62623383061936, "Hyperlipidaemia ": 17.054909820445843, "Immune reconstitution inflammatory syndrome ": 153.63691266766077, "Immune reconstitution inflammatory syndrome associated tuberculosis ": 177.95585838105103, "Lactic acidosis ": 3.4829111833959803, "Live birth ": 10.06468039475834, "Low birth weight baby ": 12.501062023369682, "Maternal exposure during pregnancy ": 8.53356983614865, "Mental disorder ": 2.070139029757534, "Metabolic acidosis ": 2.463018969322534, "Nephropathy toxic ": 6.768534060700462, "Neuropathy peripheral ": 2.144363754289252, "No adverse event ": 11.8860103008112, "Oesophageal candidiasis ": 19.67147825298624, "Oral disorder ": 15.234661281625398, "Osteoporosis ": 3.1109798076540023, "Pathogen resistance ": 100.8737448008916, "Peripheral sensory neuropathy ": 10.5265978137022, "Pleocytosis ": 76.14576800980407, "Pneumocystis jirovecii pneumonia ": 26.9502989311732, "Premature baby ": 4.793131037156078, "Premature delivery ": 9.274468500126233, "Proteinuria ": 5.618582939795924, "Renal impairment ": 3.6820037493235898, "Skin exfoliation ": 2.2729067107993752, "Spina bifida ": 34.25068771593388, "Treatment failure ": 4.003533625580308, "Treatment noncompliance ": 26.909697345270796, "Type 2 diabetes mellitus ": 3.7856860679563913, "Viraemia ": 35.77081299102465, "Viral load increased ": 26.852048780969945, "Viral mutation identified ": 142.38259860508552, "Virologic failure ": 137.44067924120804} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/324.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/324.json new file mode 100644 index 00000000000..7cf8348884d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/324.json @@ -0,0 +1 @@ +{"Acute pulmonary oedema ": 5.268153293617144, "Adverse event ": 2.896361976859951, "Anaemia ": 2.519864053837227, "Anaphylactoid reaction ": 2.5474246826309743, "Asphyxia ": 7.798539548111271, "Atrial fibrillation ": 3.188454027293862, "Atrial flutter ": 4.740390194507171, "Bronchospasm ": 9.632793347678753, "COVID-19 pneumonia ": 2.265119647307373, "Cardiac failure acute ": 2.804596034246313, "Chest discomfort ": 2.702118680198537, "Coombs indirect test positive ": 586.978795038228, "Crossmatch incompatible ": 4305.221030728607, "Cytokine release syndrome ": 2.1422815053123103, "Cytomegalovirus infection ": 7.007128234211858, "Cytomegalovirus infection reactivation 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27.773926467812952, "Left ventricular failure ": 26.891434496853503, "Leukocytosis ": 12.145605580698366, "Lipase increased ": 26.601097506718855, "Malignant neoplasm progression ": 7.228553289343166, "Mitral valve incompetence ": 11.946417822285056, "Muscle spasms ": 2.109364242685745, "Musculoskeletal pain ": 2.4133468589826985, "Myeloid leukaemia ": 138.31933612043383, "Myocardial ischaemia ": 33.602464866388445, "Neutrophilia ": 47.93547485481319, "Osteomyelitis ": 11.691476398155068, "Pancreatitis ": 5.33977684664884, "Pancytopenia ": 3.66827926951917, "Philadelphia chromosome positive ": 512.8557772777307, "Photosensitivity reaction ": 6.910562087939298, "Platelet count decreased ": 3.510906297573464, "Pleural effusion ": 23.185611889913705, "Proteinuria ": 2.612603248618689, "Pulmonary hypertension ": 19.216775396516987, "Rectal haemorrhage ": 4.753150628198638, "Right ventricular dysfunction ": 115.5225267784365, "Splenomegaly ": 7.765346958783179, "Supraventricular tachycardia 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/328.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/328.json new file mode 100644 index 00000000000..de2d4a49377 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/328.json @@ -0,0 +1 @@ +{"Death ": 19.576393406500067, "Neutropenia ": 124.38926742241983, "Pneumonia ": 87.82472351569312} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/329.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/329.json new file mode 100644 index 00000000000..9036f4c6c12 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/329.json @@ -0,0 +1 @@ +{"Asthma ": 25.290203684662824, "Blood test abnormal ": 50.85673159442715, "Chronic obstructive pulmonary disease ": 12.746683007749708, "Cough ": 3.2967735777529983, "Drug intolerance ": 5.803328697589451, "Dyspnoea ": 3.0699542357107457, "Full blood count abnormal ": 44.69104487310736, "Gastrooesophageal reflux disease ": 19.83139000450531, "Inflammatory bowel disease ": 167.861493551287, "Loss of personal independence in daily activities ": 16.424389136078307, "Nasopharyngitis ": 6.79905919571834, "Obstructive airways disorder ": 81.25887567309145, "Pneumonia ": 2.1384378514288143, "Therapeutic product effect decreased ": 13.85321575408534, "Therapeutic product effect incomplete ": 16.78249805602869, "Weight decreased ": 4.09835450614966, "Weight increased ": 6.561338307726702, "Wheezing ": 30.30733704577424} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/33.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/33.json new file mode 100644 index 00000000000..6c1e0c33057 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/33.json @@ -0,0 +1 @@ +{"Abnormal behaviour 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"Product prescribing error ": 3.1329042308590327, "Product prescribing issue ": 15.2101453494379, "Product use in unapproved indication ": 2.0808299618657764, "Product use issue ": 3.10136072162112, "Productive cough ": 2.161706115810852, "Prurigo ": 46.58721842142428, "Pruritus ": 2.361609636502864, "Psychomotor hyperactivity ": 5.578688781074466, "Psychotic disorder ": 2.172102247015496, "Rash maculo-papular ": 3.801016806334382, "Rash morbilliform ": 2.220691224974386, "Rash pustular ": 5.554646601551784, "Respiratory distress ": 2.2982164399976583, "Restlessness ": 2.034319388879596, "Rhabdomyolysis ": 4.131883655065865, "Somnolence ": 4.629284085290047, "Suicide attempt ": 3.833707595281592, "Swelling face ": 2.224771964737958, "Tachycardia ": 2.6469209713109727, "Therapeutic product ineffective ": 13.03801580911446, "Toxic skin eruption ": 3.860998897638804, "Tubulointerstitial nephritis ": 2.1961648679194203, "Urticaria ": 2.022772139277583, "Vasculitis ": 5.043565772697956} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/330.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/330.json new file mode 100644 index 00000000000..a3ed204a563 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/330.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 64.1466668154165, "Anaemia ": 2.773600248157204, "Febrile neutropenia ": 22.974699239047236, "Infection ": 4.098102477356623, "Myelodysplastic syndrome ": 36.72531265495387, "Myelosuppression ": 32.22196203941578, "Neutropenia ": 4.120542324768252, "Neutrophil count decreased ": 5.360803457249633, "Oedema peripheral ": 3.350266980608194, "Off label use ": 5.198290546056645, "Pancytopenia ": 11.807840480875372, "Platelet count decreased ": 2.888023534767349, "Pneumonia ": 2.2095648492553663, "Product use in unapproved indication ": 3.4035108444085265, "Thrombocytopenia ": 2.9335260498024884, "White blood cell count decreased ": 4.757543114170407} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/331.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/331.json new file mode 100644 index 00000000000..33f729a706e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/331.json @@ -0,0 +1 @@ +{"Haemoglobin decreased ": 12.837422319633935, "Platelet count decreased ": 7.421775372156706} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/332.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/332.json new file mode 100644 index 00000000000..47e47925333 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/332.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 21.37375107424446, "Altered state of consciousness ": 5.130072330182727, "Ascites ": 8.375447960336, "Blood bilirubin increased ": 8.40632416116314, "Cerebral haemorrhage ": 8.521165245272234, "Condition aggravated ": 2.65076977535152, "Cystitis haemorrhagic ": 116.9428865386252, "Death ": 2.3846036722228083, "Disease progression ": 8.015597979624063, "Epistaxis ": 4.479242223399748, "Febrile neutropenia ": 3.649380583156115, "Gastric haemorrhage ": 17.818560609472588, "Gastrointestinal haemorrhage ": 23.35457233548314, "Graft versus host disease ": 72.64573373980406, "Haematochezia ": 5.002377133548935, "Haematuria ": 7.7623825337670675, "Haemorrhage ": 8.510115711550345, "Hepatic failure ": 7.872684492667658, "Hypotension ": 12.27976733642542, "Infection ": 2.733157101792721, "Lower gastrointestinal haemorrhage ": 31.192443568856344, "Melaena ": 11.40631664311037, "Mouth haemorrhage ": 26.962058141958032, "Multiple organ dysfunction syndrome ": 75.27726498668905, "Off label use ": 10.415596874125876, "Pulmonary alveolar haemorrhage ": 106.68041045205912, "Pulmonary 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file mode 100644 index 00000000000..6f407e9d1f9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/334.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 3.405563244573649, "Alcohol abuse ": 25.62701757663471, "Alcohol poisoning ": 54.9834279945252, "Anaemia ": 6.120177669540603, "Aortic arteriosclerosis ": 28.39991469915388, "Arrhythmia ": 2.039099155055584, "Aspartate aminotransferase increased ": 6.72876353109185, "Blood albumin decreased ": 23.40173086900297, "Blood alkaline phosphatase increased ": 2.078750332025528, "Blood bilirubin increased ": 4.261407411350907, "Blood calcium decreased ": 28.8577423156231, "Blood chloride decreased ": 42.32635729167484, "Blood creatinine increased ": 4.342163333465987, "Blood potassium decreased ": 6.9238733864126285, "Blood sodium decreased ": 11.16753490058625, "Blood thyroid stimulating hormone increased ": 7.788137702732822, "Blood urea increased ": 3.247060573801644, "Bone tuberculosis ": 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increased ": 6.460598504299959, "Hepatic failure ": 3.441675655874743, "Hepatitis ": 2.6335387304733926, "Hepatitis toxic ": 24.296871103636636, "Hepatotoxicity ": 5.850847030484843, "Hypnopompic hallucination ": 726.6622874169204, "Hypoalbuminaemia ": 11.386066880600126, "Hypocalcaemia ": 7.928129374143202, "Hypokalaemia ": 7.562096794244004, "Hypomagnesaemia ": 11.311169249808838, "Hypothyroidism ": 4.614435957586953, "Incorrect product administration duration ": 93.08773083028922, "Intentional product use issue ": 13.289884381988626, "Lethargy ": 2.526978350067973, "Mental disorder ": 2.98590434709295, "Metabolic acidosis ": 2.2356882101608258, "Nephropathy toxic ": 4.955711867891541, "Neuropathy peripheral ": 5.197840976420573, "Oesophageal candidiasis ": 24.628368010155995, "Off label use ": 2.597788267326985, "Oral candidiasis ": 10.854896403765474, "Otitis media ": 22.79196815930085, "Phobia ": 93.89526946675883, "Platelet count decreased ": 4.231463195108359, "Pneumothorax ": 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/335.json @@ -0,0 +1 @@ +{"Weight increased ": 50.380842379226486} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/336.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/336.json new file mode 100644 index 00000000000..ccd0de80bf8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/336.json @@ -0,0 +1 @@ +{"Anaemia ": 2.4475412765198734, "Blood creatinine increased ": 6.356461844484439, "Blood urea increased ": 26.34738675984425, "Confusional state ": 3.070327544150323, "Depression ": 3.2789827227433053, "Electrocardiogram QT prolonged ": 64.12384229545944, "Haemoglobin decreased ": 5.441607201719993, "Hepatic function abnormal ": 7.170335901092754, "Hepatotoxicity ": 22.390869375384185, "Hypoaesthesia oral ": 18.55018265650824, "Incorrect product administration duration ": 48.88141291747056, "Insomnia ": 2.112522584101962, "Neuropathy peripheral ": 13.72454405272617, "Neutropenia ": 2.276193412336826, "Product use in unapproved indication ": 3.137272930435328, "Product use issue ": 7.21387344947387, "Tuberculosis ": 51.57525033759398, "Visual impairment ": 3.6410359803174464} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/337.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/337.json new file mode 100644 index 00000000000..b81ed6282f4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/337.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 3.469085456758264, "Anaemia ": 3.5449401576175035, "Aspartate aminotransferase increased ": 3.1289530340819973, "Atrioventricular block first degree ": 44.58159574087806, "Back pain ": 4.515222883434026, "Blood alkaline phosphatase increased ": 4.068678751703394, "Blood calcium increased ": 21.03030882339737, "Blood cholesterol decreased ": 127.25585428435734, "Blood creatine increased ": 20.313165597450908, "Blood potassium increased ": 6.328243870282749, "Blood urea increased ": 4.096522747734538, "Bone lesion ": 105.8441474386898, "Bone pain ": 3.847668578436301, "Bradykinesia ": 20.277515825425343, "Breast cancer ": 5.430666060399886, "Breast cancer metastatic ": 17.192373717274624, "Breast cancer recurrent ": 32.63378619914449, "Carbohydrate antigen 15-3 increased ": 115.4651345882878, "Cellulitis ": 2.3739034807456703, "Cognitive disorder ": 2.8873848975006706, "Decreased appetite ": 4.466917007901024, "Dementia ": 10.379835404757944, "Depression ": 2.2608074892830814, "Diabetes mellitus inadequate control ": 2.9057128299904025, "Diarrhoea ": 2.172331260506966, "Disease progression ": 5.385014409699721, "Dysuria ": 6.929501558249445, "Ejection fraction decreased ": 5.64644267530151, "Electrocardiogram QT prolonged ": 11.24752656752983, "Febrile neutropenia ": 2.286582056362342, "Gamma-glutamyltransferase increased ": 2.874228615359094, "Gastric polyps ": 48.31706299587351, "Gastroenteritis viral ": 16.33635949422196, "General physical health deterioration ": 2.6188303421834647, "Hepatic enzyme increased ": 2.137608101974109, "Hepatotoxicity ": 3.856622085120218, "Hiatus hernia ": 7.604055509230259, "Hypercalcaemia ": 5.607487301895458, "Hypocalcaemia ": 14.78450658727745, "Incorrect product administration duration ": 5.003583658567151, "Liver function test abnormal ": 15.638355665605555, "Malignant neoplasm progression ": 8.211590523692863, "Metastases to bone ": 63.03282663313394, "Metastases to central nervous system ": 6.587491386229211, "Metastases to liver ": 38.10326855860724, "Metastases to lung ": 15.123245947783852, "Metastases to lymph nodes ": 56.437294754440025, "Metastases to peritoneum ": 26.360779971070592, "Metastases to spine ": 61.8211325294319, "Mucosal inflammation ": 9.880017584135532, "Neoplasm progression ": 10.567728316547894, "Neutropenia ": 8.9469824070308, "Neutrophil count decreased ": 3.400075075485248, "Osteonecrosis of jaw ": 67.39420292653622, "Pleural effusion ": 3.3941981078152272, "Prostate cancer ": 7.172807603969819, "Prostatic specific antigen increased ": 13.005275668098822, "Stress cardiomyopathy ": 22.053231000965635, "Therapeutic response decreased ": 2.5901418770560047, "Therapy partial responder ": 10.429781614492136, "Transaminases increased ": 3.2932791141948923, "Tumour marker increased ": 20.024837824377897} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/338.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/338.json new file mode 100644 index 00000000000..2cf7a26cd0e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/338.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 5.25433925655206, "Adverse event ": 2.226888134868513, "Altered state of 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reconstitution inflammatory syndrome ": 67.9189795859046, "Kaposi's sarcoma ": 47.905623362700105, "Lipids increased ": 106.53451714813713, "Low density lipoprotein increased ": 27.64040309252692, "Lymphoma ": 9.143998226139692, "Mycobacterium avium complex infection ": 39.47881318032175, "Neural tube defect ": 65.42523578250851, "Neurotoxicity ": 8.714819067114021, "Osteopenia ": 2.8386089925677567, "Osteoporosis ": 2.990841928683331, "Pancreatitis ": 2.631736997926445, "Pneumocystis jirovecii pneumonia ": 10.607492205056912, "Post-traumatic stress disorder ": 40.6177379573548, "Renal disorder ": 4.828920875186944, "Renal impairment ": 5.319122519006234, "Sinusitis ": 2.1372414502498835, "Syphilis ": 116.42312442563582, "Treatment noncompliance ": 11.055109358215985, "Viral load increased ": 43.65226576249108, "Virologic failure ": 30.98274301988402, "Weight decreased ": 2.008572677562373, "Weight increased ": 6.697973130156867, "Wrong technique in product usage process ": 2.527997699987852} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/339.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/339.json new file mode 100644 index 00000000000..4271ca8e395 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/339.json @@ -0,0 +1 @@ +{"Abnormal weight gain ": 44.96482191199119, "Aggression ": 2.2133642558313658, "Aphonia ": 11.179078206059978, "Asthma ": 5.409335148203829, "Depressed mood ": 2.7432208911221894, "Dermatitis exfoliative generalised ": 7.623199009910531, "Disturbance in attention ": 2.0283881500139285, "Drug hypersensitivity ": 2.946506145206897, "Drug reaction with eosinophilia and systemic symptoms ": 2.3658860560926374, "Dry mouth ": 2.15119287518281, "Electrocardiogram QT prolonged ": 2.6230803387564854, "Eosinophilia ": 3.844574625483778, "Face oedema ": 2.386858346690652, "Full blood count abnormal ": 8.439381944953862, "Generalised tonic-clonic seizure ": 2.5828653294725097, "Hepatic cytolysis ": 2.5158029448369725, "Incorrect dose administered ": 3.005280615616549, "Increased appetite ": 8.575065830098017, "Intentional overdose ": 4.923887587801009, "Intentional self-injury ": 8.434215511454896, "Lip swelling ": 2.0017512776510054, "Loss of personal independence in daily activities ": 6.004930061983674, "Multiple organ dysfunction syndrome ": 2.172706433892237, "Neuralgia ": 2.360310786046996, "Nightmare ": 2.6705397704222027, "Oedema ": 2.050463468575645, "Overdose ": 2.921857486838308, "Palpitations ": 2.125269300558198, "Pancoast's syndrome ": 4182.342890189411, "Papule ": 6.877681052032816, "Paraesthesia oral ": 2.014524297634052, "Petit mal epilepsy ": 18.491660505131037, "Photosensitivity reaction ": 5.9867980874682, "Product prescribing error ": 6.887527920789664, "Product substitution issue ": 6.438806872786277, "Product use in unapproved indication ": 2.08807258665603, "Product use issue ": 2.900080254614198, "Productive cough ": 7.694851592706317, "Pruritus ": 2.2775029291853244, "Rash maculo-papular ": 2.8120161366622383, "Rash pruritic ": 2.1994532012948205, "Sleep apnoea syndrome ": 8.043705822563235, "Sleep disorder due to a general medical condition ": 23.36322839179094, "Somnolence ": 3.3077312639454184, "Speech disorder ": 3.6926575066760736, "Swelling face ": 2.000409859292987, "Swollen tongue ": 2.7625054080265263, "Tachycardia ": 2.090378938673532, "Therapeutic product effect incomplete ": 8.12869851958033, "Therapeutic response unexpected ": 6.18754248686704, "Upper respiratory tract infection ": 3.449905412019484, "Urticaria ": 3.219599444249587, "Weight increased ": 3.240443628515908, "Wheezing ": 9.892101836178927, "Wrong product administered ": 5.331284447257246} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/34.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/34.json new file mode 100644 index 00000000000..e988740700e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/34.json @@ -0,0 +1 @@ +{"Diarrhoea ": 4.689983751911651, "Disease progression ": 23.84815653129202, "Drug resistance ": 46.1857950846204, "Malignant neoplasm progression ": 10.974094265330796, "Metastases to central nervous system ": 54.04114445315533, "Paronychia ": 245.1656015327333} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/340.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/340.json new file mode 100644 index 00000000000..d7404931e11 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/340.json @@ -0,0 +1 @@ +{"Hyperglycaemia ": 59.36372930017131, "Hypoglycaemia ": 21.92506809467372} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/341.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/341.json new file mode 100644 index 00000000000..8cdd26d6833 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/341.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 4.130620441731502, "Acute generalised exanthematous pustulosis ": 2.7241377160235625, "Acute graft versus host disease ": 4.028276705264547, "Acute leukaemia ": 3.621903728955592, "Acute lymphocytic leukaemia ": 6.220345287342108, "Acute lymphocytic leukaemia recurrent ": 8.821967635439831, "Acute myeloid leukaemia ": 3.976809374618505, "Acute pulmonary oedema ": 2.868006946523296, "Acute respiratory distress syndrome ": 2.978169948242065, "Acute respiratory failure ": 3.3362800928455103, "Adenoviral hepatitis ": 33.84639287822629, "Adenovirus infection ": 4.158450733666188, "Adrenal insufficiency ": 2.764855564979181, "Adult T-cell lymphoma/leukaemia ": 21.542497454520117, "Allergy test negative ": 64.30802692677703, "Amyloidosis ": 7.698644359007879, "Anaphylactic reaction ": 2.7661810063802044, "Anaphylactic shock ": 3.6087063386861833, "Anaphylactoid shock ": 10.887872550506422, "Antinuclear antibody positive ": 2.8132376218259, "Apgar score low ": 3.3918928028152635, "Aspergillus infection ": 10.402015594875046, "Atelectasis ": 5.011152585098555, "B-cell lymphoma recurrent ": 35.52400942881861, "Bacteraemia ": 3.914875550691824, "Bacterial infection ": 2.78245281216752, "Bacterial sepsis ": 4.269094541303519, "Biliary colic ": 3.930677299317784, "Blood disorder ": 3.12477553573266, "Blood fibrinogen decreased ": 5.652027845801441, "Blood gases abnormal ": 27.086967440957697, "Blood immunoglobulin G increased ": 5.41268101783985, "Blood lactate dehydrogenase increased ": 2.8922586845236564, "Blood lactic acid increased ": 5.075206923498662, "Bone lesion ": 7.5374123627980065, "Bone marrow failure ": 2.546357660358261, "Bradycardia foetal ": 4.245773985337802, "Brain abscess ": 7.215293244777227, "Brain herniation ": 2.9301287044821622, "Brain oedema ": 5.059762258463214, "Breech presentation ": 9.202093282503254, "Bronchial wall thickening ": 12.038923102175795, "Bronchopulmonary aspergillosis ": 12.308115489229042, "Bronchospasm ": 3.0233596803325407, "COVID-19 pneumonia ": 4.713779535524051, "CSF oligoclonal band present ": 62.248037504330085, "Candida infection ": 4.102949968995659, "Cardiac dysfunction ": 3.48688488441041, "Cardiac failure ": 2.1338163557211223, "Cardio-respiratory arrest ": 2.2332003278149486, "Cardiomegaly ": 2.005164110781153, "Cardiotoxicity ": 4.376885719455959, "Cardiovascular insufficiency ": 8.870738848548678, "Cataract subcapsular ": 15.365270294327734, "Cell marker increased ": 63.48473717304628, "Cell-mediated cytotoxicity ": 259.57356725092893, "Cellulitis ": 2.495316253822397, "Central nervous system lesion ": 5.163146596272349, "Central nervous system vasculitis ": 7.549605090733313, "Chronic graft versus host disease ": 2.1893186620971488, "Chronic lymphocytic leukaemia recurrent ": 11.562296381116036, "Clonic convulsion ": 3.641951468477932, "Clostridium difficile colitis ": 4.556810577087086, "Clostridium test positive ": 3.279313032348664, "Coma scale abnormal ": 3.113776279073339, "Computerised tomogram thorax abnormal ": 19.381929803373566, "Corneal disorder ": 8.739561011373798, "Corneal infiltrates ": 17.68565594347568, "Corneal oedema ": 6.267210427992417, "Corneal perforation ": 13.440651301634317, "Cryptococcosis ": 17.69061819323598, "Cushing's syndrome ": 2.305299583378042, "Cystitis haemorrhagic ": 2.5748017398969987, "Cytokine release syndrome ": 3.653095420792632, "Cytomegalovirus chorioretinitis ": 13.397115501426963, "Cytomegalovirus infection ": 3.5737760299059693, "Cytomegalovirus infection reactivation ": 5.005234043528828, "Cytopenia ": 9.822803176679155, "Deafness bilateral ": 3.015704647640087, "Deep vein thrombosis ": 2.050174562664356, "Diabetes insipidus ": 2.223835925107398, "Diastolic dysfunction ": 2.592745173485102, "Differentiation syndrome ": 12.34487330368347, "Diffuse large B-cell lymphoma ": 12.26780926600238, "Diffuse large B-cell lymphoma recurrent ": 25.393054013737864, "Diffuse large B-cell lymphoma refractory ": 26.700252151645184, "Disease progression ": 6.355838725557665, "Disease recurrence ": 2.5756799258711207, "Disseminated cryptococcosis ": 22.331520793197928, "Disseminated tuberculosis ": 7.844528668331018, "Drug clearance decreased ": 12.770183216085057, "Drug ineffective for unapproved indication ": 3.822502038601015, "Drug resistance ": 2.8804475710244724, "Ecthyma ": 22.90318644797652, "Embolic stroke ": 2.025825239845729, "Embolism ": 3.7394650602255, "Encephalitis ": 2.536917728165244, "Encephalopathy ": 2.0056400845430837, "Endophthalmitis ": 6.643884540522487, "Engraftment syndrome ": 54.12105346112561, "Enterococcal infection ": 5.63388162505178, "Enterocolitis ": 3.920765325097416, "Eosinophil count abnormal ": 10.01910061325164, "Epstein-Barr virus infection ": 2.246561999745265, "Escherichia bacteraemia ": 5.557893424063658, "Escherichia infection ": 3.113776279073339, "Escherichia sepsis ": 13.393057887307467, "Exophthalmos ": 3.1570632376240986, "Exposure during pregnancy ": 2.1565354828860306, "Faeces soft ": 2.213127954856789, "Failure to thrive ": 2.933536706382696, "Febrile bone marrow aplasia ": 7.274988606907375, "Febrile neutropenia ": 11.238676483698516, "Foetal distress syndrome ": 5.385572987717242, "Foetal exposure during pregnancy ": 3.6758098919873463, "Foetal growth restriction ": 6.874809424165415, "Foetal hypokinesia ": 7.534699617903125, "Follicular lymphoma ": 15.589793899208374, "Food poisoning ": 3.975919377901615, "Full blood count abnormal ": 2.0046528464244373, "Full blood count decreased ": 4.7653327088863815, "Fusarium infection ": 11.579274969526171, "Gastrointestinal inflammation ": 5.315448401256777, "Gastrointestinal necrosis ": 4.014330847842955, "Gastrointestinal perforation ": 2.213774126933728, "Gene mutation ": 10.460209424592335, "Haematotoxicity ": 4.177160855861352, "Haemodynamic instability ": 4.522160790291756, "Haemophagocytic lymphohistiocytosis ": 6.631100710643286, "Haemorrhoidal haemorrhage ": 2.0084453982898096, "Hepatic cytolysis ": 2.454616603880561, "Hepatic mass ": 3.6865592018792928, "Hepatitis B reactivation ": 11.16293026474227, "Hepatomegaly ": 2.2145979194151817, "Hepatosplenomegaly ": 2.696924539385122, "Herpes simplex encephalitis ": 33.339552058082646, "Hiccups ": 3.0719607239476834, "Hydrocephalus ": 5.229250910004191, "Hyperaemia ": 2.3627001535164878, "Hyperbilirubinaemia ": 2.529004150628658, "Hypercapnia ": 2.49655652406694, "Hyperthermia malignant ": 2.4602311831937564, "Hypertonic bladder ": 4.910122293747853, "Hypertransaminasaemia ": 2.4084965664063818, "Hypertriglyceridaemia ": 4.142055566238585, "Hypervolaemia ": 2.9397792575712067, "Hypocalcaemia ": 2.595050792624215, "Hypofibrinogenaemia ": 6.548779357266675, "Hypogammaglobulinaemia ": 9.88775939603276, "Hypopyon ": 15.033950482812074, "Hypotension ": 2.3023963663212563, "Hypoventilation ": 3.932546430844932, "Hypovolaemia ": 2.575047791369834, "Hypoxia ": 3.3513604497961764, "Hypoxic-ischaemic encephalopathy ": 2.746147720263091, "Ileus paralytic ": 2.350763621930446, "Immunosuppression ": 2.878827955960284, "Infection ": 2.8162433887863134, "Intestinal perforation ": 3.0023856313370945, "Keratoconus ": 29.43380923749087, "Keratopathy ": 9.379329769038405, "Klebsiella bacteraemia ": 9.443932765713411, "Klebsiella infection ": 10.976030207850355, "Klebsiella sepsis ": 11.051284174282197, "Large intestine perforation ": 3.573436807280728, "Laryngospasm ": 2.501408092742924, "Leukocytosis ": 2.6152985389337187, "Light chain analysis increased ": 43.01342858391224, "Live birth ": 6.5158864372304, "Liver abscess ": 2.864475806966906, "Low birth weight baby ": 7.413601751008866, "Lung abscess ": 6.040423370051107, "Lung consolidation ": 3.434866768682372, "Lung infiltration ": 2.769056280144776, "Lung opacity ": 5.427698759405109, "Lymphopenia ": 7.590006305188066, "Macule ": 3.737861339238013, "Madarosis ": 3.414606412778061, "Maternal exposure during pregnancy ": 2.3210288984604035, "Meningitis ": 2.8334366671711573, "Meningitis cryptococcal ": 7.818018911247948, "Meningitis tuberculous ": 26.543622274472067, "Mesothelioma ": 33.10717474191843, "Metabolic acidosis ": 2.11532608318124, "Metastases to bone ": 2.3885674742849763, "Metastasis ": 2.127094175150375, "Mitochondrial DNA mutation ": 140.37039197993863, "Mixed liver injury ": 3.3701055919535987, "Molluscum contagiosum ": 15.00024975303728, "Mucormycosis ": 11.967548179451574, "Mucosal inflammation ": 3.907924431932402, "Multiple organ dysfunction syndrome ": 4.893857759065851, "Multiple-drug resistance ": 4.617778664636292, "Myelodysplastic syndrome ": 6.3629723083324405, "Myelosuppression ": 4.441662516911432, "Myoclonus ": 3.263760722752866, "Myopathy ": 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"Platelet count decreased ": 2.396173369073395, "Platelet disorder ": 3.2083217914490456, "Pleocytosis ": 17.672185714803042, "Pneumocystis jirovecii pneumonia ": 8.15847604581049, "Pneumomediastinum ": 13.122434125717852, "Pneumonia ": 2.7421103860474614, "Pneumonia bacterial ": 4.1438033194214325, "Pneumonia cytomegaloviral ": 5.918473356083501, "Pneumonia fungal ": 7.701276323980196, "Pneumonia klebsiella ": 8.676261447654184, "Pneumothorax ": 3.788054047904079, "Polyneuropathy ": 3.4112238870047693, "Post procedural hypotension ": 36.44921523683357, "Posterior reversible encephalopathy syndrome ": 4.975472679193486, "Pre-eclampsia ": 2.730073160099671, "Pregnancy ": 2.0175715456179266, "Premature baby ": 8.904621416655322, "Premature delivery ": 7.769951733531802, "Premature labour ": 3.7535544870881794, "Procedural hypotension ": 13.566224474182846, "Procedural nausea ": 40.97070936748767, "Procedural vomiting ": 36.59828765358079, "Product use in unapproved indication ": 2.421297119049458, "Progressive multifocal leukoencephalopathy ": 6.673065806855803, "Propofol infusion syndrome ": 10.389235100926498, "Prostate cancer metastatic ": 3.499165893191574, "Protein total decreased ": 2.0582087950586083, "Pseudomonal sepsis ": 7.035359288062929, "Pseudomonas infection ": 6.617214001138983, "Pulmonary haemorrhage ": 5.065146352759211, "Pulmonary tuberculosis ": 2.6569342191727223, "Pulseless electrical activity ": 2.4729562542430847, "Purpura senile ": 22.567870136316973, "Quadriplegia ": 4.816473021289911, "Resorption bone increased ": 30.384538905424407, "Respiratory acidosis ": 3.0560990789729097, "Respiratory failure ": 3.3813762133615466, "Reye's syndrome ": 41.56394602037711, "Second primary malignancy ": 2.058259686700416, "Sense of oppression ": 2.1616747697305048, "Sepsis ": 4.525773325240006, "Septic shock ": 5.612215983418823, "Shock ": 2.4498908774641093, "Skin abrasion ": 3.3740446283076952, "Skin lesion ": 2.0889860783053176, "Skin mass ": 2.876574846541846, "Sleep disorder due to a general medical condition ": 2.0481557647160296, "Soft tissue necrosis ": 10.947501307617369, "Spina bifida ": 2.5860478093969523, "Staphylococcal bacteraemia ": 5.937573221561912, "Staphylococcal infection ": 2.4063704825053667, "Staphylococcal sepsis ": 2.2084225157174915, "Status epilepticus ": 3.2885190921244374, "Steroid diabetes ": 7.5867552321682625, "Streptococcal infection ": 3.197194006509636, "Stridor ": 3.2539639021004136, "Strongyloidiasis ": 52.51102740603742, "Subcutaneous emphysema ": 11.839374203600183, "Substance-induced psychotic disorder ": 5.315356197710391, "Systemic candida ": 6.78452591572543, "Systemic mycosis ": 6.428180304624633, "Tachypnoea ": 4.236357949203008, "Tarsal tunnel syndrome ": 33.369830107623706, "Tetany ": 4.409035809830213, "Therapeutic response decreased ": 2.30462599334402, "Therapy non-responder ": 4.149429038144135, "Therapy partial responder ": 5.6667891551650245, "Thrombocytopenia ": 3.248952010887363, "Thrombotic microangiopathy ": 2.305742017448785, "Tonic clonic movements ": 5.192241620809898, "Toxic epidermal necrolysis ": 3.3265093497102813, "Transaminases abnormal ": 11.42676618840779, "Tuberculoma of central nervous system ": 25.811735876102677, "Tuberculosis of central nervous system ": 43.1944194736409, "Tumour lysis syndrome ": 10.714436601276576, "Type I hypersensitivity ": 7.268901896268634, "Ulcerative keratitis ": 4.965966507886051, "VIth nerve paralysis ": 5.794511894901075, "Varicella zoster virus infection ": 3.2738665202140567, "Vestibular disorder ": 3.2434289973379284, "Visual acuity reduced ": 2.2924034765118444} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/342.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/342.json new file mode 100644 index 00000000000..ec09e3a37d0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/342.json @@ -0,0 +1 @@ +{"Anaphylactic shock ": 11.185645503700629, "Bradycardia ": 62.28228441829533, "Cardiac arrest ": 29.16191884508936, "Cardio-respiratory arrest ": 12.93173515765512, "Delirium ": 8.969880033973977, "Drug interaction ": 2.454379115203677, "Extravasation ": 90.8609320988482, "Generalised tonic-clonic seizure ": 9.923100689383936, "Hyperthermia ": 67.87160182829832, "Hypotension ": 6.4042122801462495, "Myoclonus ": 34.91096421203645, "Postoperative delirium ": 14791.92902198019, "Product administered to patient of inappropriate age ": 90.26655160878968, "Product use in unapproved indication ": 2.126510349780905, "Respiratory arrest ": 15.698888846479743, "Withdrawal syndrome ": 16.982351414976133} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/343.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/343.json new file mode 100644 index 00000000000..3cfa940db21 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/343.json @@ -0,0 +1 @@ +{"Agitation ": 9.927963903453598, "Anaphylactic shock ": 2.6236905544891456, "Blood pressure decreased ": 2.493666376935629, "Bradycardia ": 21.72925237247872, "Cardiac arrest ": 14.205922206338156, "Catatonia ": 50.98857888655453, "Delirium ": 22.479984511656056, "Drug interaction ": 2.956339243484857, "Drug withdrawal syndrome ": 5.25714211792707, "Drug withdrawal syndrome neonatal ": 20.131236801456076, "Dyskinesia ": 10.141396308326074, "Electrocardiogram QT prolonged ": 3.3765495905314906, "Electrolyte imbalance ": 19.769814507836617, "Exposure during pregnancy ": 2.8357807714388543, "Foetal exposure during pregnancy ": 13.070754128487645, "Haemodynamic instability ": 32.19564129964526, "Heart rate decreased ": 5.665609169208732, "Hyperthermia ": 11.327580015104171, "Hyperthermia malignant ": 106.40464124789246, "Hypotension ": 7.160703665576461, "Hypotonia ": 8.258811560657222, "Hypoxia ": 7.118176340894656, "Incorrect dose administered ": 3.450575076430014, "Intentional product use issue ": 4.518448539481129, "Laryngomalacia ": 799.1178864668753, "Maternal exposure during pregnancy ": 4.39142746434673, "Multiple organ dysfunction syndrome ": 8.805195481335653, "Myoclonus ": 11.69048483037068, "Neuroleptic malignant syndrome ": 6.936658181368837, "Overdose ": 2.1573167509016526, "Oxygen saturation decreased ": 4.111406849262989, "Poor feeding infant ": 80.6401665042981, "Porphyria acute ": 273.6694587616796, "Potentiating drug interaction ": 34.47845662404311, "Premature baby ": 17.384291923192563, "Premature delivery ": 22.995042803899363, "Product administered to patient of inappropriate age ": 72.59612084088424, "Product use in unapproved indication ": 3.463593450042466, "Respiratory depression ": 28.73982369144186, "Respiratory failure ": 9.175080296591018, "Restlessness ": 2.887949145125689, "Septic shock ": 5.164063319775541, "Sinus tachycardia ": 10.079415217941746, "Small for dates baby ": 76.56535589985788, "Tachycardia ": 2.8067732548361444, "Tachypnoea ": 18.70953887988479, "Therapeutic product effect incomplete ": 2.33233540626082, "Toxicity to various agents ": 2.264310416950857, "Upper airway obstruction ": 240.49301258016715, "Withdrawal syndrome ": 15.243475168220606} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/344.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/344.json new file mode 100644 index 00000000000..e04327cbcd8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/344.json @@ -0,0 +1 @@ +{"Decreased appetite ": 4.379024180915872, "Febrile neutropenia ": 17.89241831710447, "Hepatic function abnormal ": 15.457328056668027, "Leukopenia ": 11.870806265102384, "Myelosuppression ": 179.84077526992706, "Neutrophil count decreased ": 20.877303544375746, "Platelet count decreased ": 8.024006433003622, "White blood cell count decreased ": 19.313771244146363} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/345.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/345.json new file mode 100644 index 00000000000..d2c6ba44035 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/345.json @@ -0,0 +1 @@ +{"Decreased appetite ": 4.593587722755362, "Drug interaction ": 14.210294604701632, "Epilepsy ": 14.508609668481167, "Product use in unapproved indication ": 18.75878662027309, "Seizure ": 7.189511946676789, "Somnolence ": 6.659640569433} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/346.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/346.json new file mode 100644 index 00000000000..5162fc4c15a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/346.json @@ -0,0 +1 @@ +{"Acute generalised exanthematous pustulosis ": 21.42782478114413, "Agranulocytosis ": 7.199926436183636, "Clostridium difficile colitis ": 189.13680161789384, "Clostridium difficile infection ": 312.5575424723945, "Condition aggravated ": 2.6499595569985366, "Death ": 2.236498412976659, "Dehydration ": 2.440967667630874, "Diarrhoea ": 3.45934891436333, "Disease recurrence ": 21.825328638329424, "Drug ineffective ": 5.318086026644783, "Eosinophilia ": 20.724558211876207, "General physical health deterioration ": 2.6584208792544746, "Hepatic cytolysis ": 7.859223317313034, "Hepatic enzyme increased ": 2.2150416323204, "Multiple organ dysfunction syndrome ": 4.835982362881562, "Off label use ": 2.2192719956832554, "Pancytopenia ": 5.893151436169882, "Product use issue ": 3.005565686521214, "Pseudomembranous colitis ": 47.81509754634903, "Rash erythematous ": 3.358881854448865, "Rash maculo-papular ": 8.011337854444514, "Rectal haemorrhage ": 4.142357476857005, "Treatment failure ": 11.770362438284357, "White blood cell count increased ": 10.662089775455318, "Wrong technique in product usage process ": 8.015360503660864} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/347.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/347.json new file mode 100644 index 00000000000..c124c35d0c0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/347.json @@ -0,0 +1 @@ +{"Dyspepsia ": 15.696342255804302} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/348.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/348.json new file mode 100644 index 00000000000..a04650395a7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/348.json @@ -0,0 +1 @@ +{"Capillary leak syndrome ": 325.70387410689574, "Constipation ": 3.231003234348296, "Cough ": 3.441303630246199, "Hypertension ": 2.238422995590371, "Neoplasm progression ": 20.642783159820247, "Neuralgia ": 14.104996693691866, "Neuropathy peripheral ": 8.55264294995484, "Off label use ": 4.895620121099849, "Pain ": 2.0656398630683253, "Pneumonia ": 3.986074434719807, "Post transplant lymphoproliferative disorder ": 95.8295562186226, "Product use in unapproved indication ": 5.083493182447235, "Product use issue ": 8.80475975568574, "Respiratory distress ": 35.678279929193934, "Thrombocytopenia ": 2.6304561803338857, "Thrombotic microangiopathy ": 63.43992733938562, "Wheezing ": 10.335886914533916} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/349.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/349.json new file mode 100644 index 00000000000..b8c2965e9e8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/349.json @@ -0,0 +1 @@ +{"Toxicity to various agents ": 35.05229652468624} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/35.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/35.json new file mode 100644 index 00000000000..56cd1b8a431 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/35.json @@ -0,0 +1 @@ +{"5-hydroxyindolacetic acid ": 499.4579594245425, "Abdominal hernia ": 4.5474259602847695, "Abdominal lymphadenopathy ": 9.759370540798306, "Abdominal mass ": 6.468663761623113, "Acne ": 3.125891664429479, "Alveolitis ": 3.1906543612341203, "Anaemia ": 2.1570735096351243, "Aphthous ulcer ": 10.51274848222767, "Ascites ": 5.301498375640612, "Atelectasis ": 4.082852631121483, "Atypical pneumonia ": 6.171036234868677, "Biliary obstruction ": 3.2376706260655514, "Blood albumin decreased ": 3.462448718389714, "Blood bilirubin abnormal ": 7.802715664683691, "Blood calcium increased ": 2.3403314432368343, "Blood cholesterol increased ": 2.512657951130949, "Blood chromogranin A increased ": 51.08027883029757, "Blood creatinine decreased ": 2.568708812284544, "Blood creatinine increased ": 2.77306004088811, "Blood lactate dehydrogenase increased ": 3.536346838385686, "Blood magnesium decreased ": 2.228789683783329, "Blood phosphorus decreased ": 2.5728424348296017, "Blood potassium decreased ": 2.1305310899788896, "Blood pressure diastolic decreased ": 9.092616237261607, "Blood pressure diastolic increased ": 2.499541575222969, "Blood pressure increased ": 2.0400831043519703, "Blood pressure systolic increased ": 9.611864717547988, "Blood triglycerides increased ": 5.776707406822929, "Blood urine present ": 2.5053126709686, "Body temperature decreased ": 6.274821373163245, "Bone cancer ": 6.003434854442488, "Bone lesion ": 9.948441682015956, "Bowel movement irregularity ": 3.9177210908273854, "Brain neoplasm ": 4.15923941283406, "Breast cancer ": 7.69211205303828, "Breast cancer female ": 4.0395693042904295, "Breast cancer metastatic ": 30.027715219178152, "Breast cancer recurrent ": 45.78169764025509, "Breast cancer stage II ": 2.5560390220774245, "Breast cancer stage IV ": 20.87903442957103, "Bundle branch block left ": 2.113348141775294, "Cachexia ": 4.862888257165355, "Cancer pain ": 6.824567845854038, "Carbohydrate antigen 15-3 increased ": 33.69136190591275, "Carcinoembryonic antigen increased ": 9.251810685309112, "Carcinoid syndrome ": 35.26338707495082, "Carcinoid tumour ": 25.124995252613115, "Carcinoid tumour pulmonary ": 124.10684493735268, "Cellulitis ": 2.1386922874364607, "Central nervous system lesion ": 2.4324825114246997, "Chapped lips ": 2.939501014896292, "Cholangitis ": 3.3657958534526253, "Clear cell renal cell carcinoma ": 10.43651603177777, "Coccydynia ": 5.593357305773886, "Concomitant disease aggravated ": 7.396489726408137, "Concomitant disease progression ": 9.22591754807395, "Cough ": 3.4703943817435525, "Crepitations ": 9.87161685521753, "Death ": 3.1521652151322668, "Decreased appetite ": 2.292394012593065, "Dehydration ": 2.5633147801284784, "Dermatitis acneiform ": 2.122595009066924, "Diabetes mellitus ": 4.081175119782228, "Disease progression ": 2.9406368613263028, "Dry skin ": 3.817373380609828, "Dyslipidaemia ": 2.0256709571599485, "Eating disorder ": 3.711984735048484, "Ejection fraction decreased ": 3.0706982150428592, "Epistaxis ": 2.656562792161421, "Exposed bone in jaw ": 42.05720486695459, "Eyelid oedema ": 2.2329637381596434, "Faeces discoloured ": 2.1523963114399183, "Feeding disorder ": 5.230621270443996, "Flatulence ": 2.0057526816575786, "Fractured sacrum ": 9.769904617971568, "Frequent bowel movements ": 2.0952357970050968, "Gallbladder disorder ": 2.0746916290197914, "General physical health deterioration ": 2.468976506471777, "Generalised oedema ": 2.8778620779073507, "Gingival swelling ": 2.7058668508747967, "Gingivitis ": 2.7370410412370303, "Glomerular filtration rate decreased ": 2.012363621273318, "Glucose tolerance impaired ": 3.191880854662179, "Haematocrit decreased ": 2.985292321842172, "Haemoglobin decreased ": 2.86928839708625, "Hepatic lesion ": 19.424493777696824, "Hepatic mass ": 9.544977231954917, "Hepatic neoplasm ": 10.010872653601751, "Hepatic pain ": 2.6467467875753243, "Hydronephrosis ": 2.355897066629236, "Hypercholesterolaemia ": 4.382970083063183, "Hyperglycaemia ": 5.648373004664907, "Hyperlipidaemia ": 4.740089003813893, "Hypertriglyceridaemia ": 6.691169263402753, "Hypophagia ": 3.2685191469359127, "Hypophosphataemia ": 2.031309109486191, "Hypoxia ": 2.075621553182282, "Ingrowing nail ": 17.27073874395147, "Injection site hypersensitivity ": 4.325629874317341, "Injection site mass ": 2.7466937902185693, "Interstitial lung disease ": 18.38645350175561, "Intestinal metastasis ": 18.58988144173605, "Intestinal obstruction ": 3.31715443991416, "Invasive ductal breast carcinoma ": 3.507314396638059, "Iron deficiency anaemia ": 2.321564740074885, "Jugular vein thrombosis ": 3.082204146471866, "KL-6 increased ": 49.38753817057257, "Lip ulceration ": 4.308765376520227, "Liver abscess ": 2.9437723717783646, "Liver function test increased ": 2.051059716885652, "Lung consolidation ": 4.913301794652878, "Lung disorder ": 4.942857754399042, "Lung infiltration ": 8.936308768339808, "Lung neoplasm ": 6.287154585902235, "Lung opacity ": 6.294669682747965, "Lymphadenopathy mediastinal ": 6.464462867837981, "Lymphangiosis carcinomatosa ": 35.32766317841092, "Lymphocyte count decreased ": 4.704634047013764, "Lymphocyte count increased ": 2.8116550337994286, "Lymphoedema ": 3.349879022962376, "Malignant ascites ": 10.65652931067766, "Malignant neoplasm progression ": 28.992812975770253, "Malignant pleural effusion ": 14.9870654855149, "Mass ": 2.679310747889804, "Metastases to adrenals ": 16.67909751977598, "Metastases to bone ": 29.473717364568763, "Metastases to central nervous system ": 16.832961994307073, "Metastases to chest wall ": 48.23251351460835, "Metastases to kidney ": 23.88215817212511, "Metastases to liver ": 37.86328708578322, "Metastases to lung ": 23.47041266434797, "Metastases to lymph nodes ": 14.897583730474066, "Metastases to meninges ": 4.5901097025415, "Metastases to pancreas ": 17.951142535889385, "Metastases to peritoneum ": 16.39410410068564, "Metastases to pleura ": 19.00742993054101, "Metastases to skin ": 21.59419135596566, "Metastases to spine ": 22.782134037202567, "Metastases to the mediastinum ": 24.129649230925665, "Metastasis ": 15.476127537598192, "Metastatic renal cell carcinoma ": 10.201155270081228, "Mouth ulceration ": 7.061031308176213, "Mucosal inflammation ": 17.805555917671324, "Musculoskeletal pain ": 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"Renal cell carcinoma ": 9.650104782768585, "Renal function test abnormal ": 2.125804950082524, "Renal mass ": 5.28680995128321, "Respiratory rate increased ": 3.131303588930069, "Second primary malignancy ": 8.531782974896268, "Skin toxicity ": 2.6620528436674338, "Small intestinal haemorrhage ": 3.5317128497867434, "Small intestine neuroendocrine tumour ": 113.71806631872823, "Spinal compression fracture ": 2.363545785844253, "Spinal cord compression ": 2.34167965248125, "Splenic lesion ": 20.32572320793658, "Steatorrhoea ": 10.769297673432783, "Stomatitis ": 30.129564049329097, "Taste disorder ": 2.7495831874741232, "Terminal state ": 2.592940712326932, "Tongue oedema ": 2.0283300029211078, "Tongue ulceration ": 3.8310760341552657, "Tooth abscess ": 2.502713380858896, "Tumour haemorrhage ": 2.132898641627506, "Tumour marker increased ": 20.60607414766788, "Tumour necrosis ": 8.066318615528973, "Ulcer ": 2.53925596295972, "Urine output decreased ": 3.647395721832288, "Urosepsis ": 3.124500738931743, "Weight decreased ": 2.5558923235153173} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/350.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/350.json new file mode 100644 index 00000000000..52761310c6d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/350.json @@ -0,0 +1 @@ +{"Pallor ": 89.76635320086456} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/351.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/351.json new file mode 100644 index 00000000000..5af9ad9b350 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/351.json @@ -0,0 +1 @@ +{"Erythema ": 14.271117903643184} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/352.json 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4.859122999566714, "Alopecia areata ": 11.62397892148129, "Alopecia totalis ": 16.121330373829316, "Anaemia ": 2.565101398913, "Aortitis ": 15.012815887936876, "Bacteraemia ": 2.677746635246708, "Bicytopenia ": 24.46520389994795, "Bone lesion ": 7.0441261277357, "Bone marrow failure ": 2.0254688072065354, "Bone pain ": 2.480038351855703, "Breast cancer ": 2.2618099766331747, "Breast cancer female ": 3.406063262185252, "Breast cancer metastatic ": 14.60093476357107, "Breast cancer recurrent ": 22.72779337959479, "Breast mass ": 2.3004530437062853, "Cancer pain ": 5.909131265198146, "Candida sepsis ": 17.748759751848592, "Carbohydrate antigen 15-3 increased ": 13.523293254243129, "Carbon dioxide decreased ": 14.264037409162777, "Cardiac dysfunction ": 4.619821581877209, "Cardiac failure ": 2.7446753355863094, "Cardiomyopathy ": 3.411860153821106, "Cardiotoxicity ": 21.51273409866998, "Chemotherapy ": 12.074243086951403, "Chronic myeloid leukaemia ": 2.7165864046703736, "Cytopenia ": 6.39954381855615, "Dacryostenosis acquired ": 55.22500378149138, "Decreased appetite ": 2.685507713161344, "Device related infection ": 3.8409877748685113, "Diarrhoea ": 3.07888808697713, "Dilated cardiomyopathy ": 2.76831511211151, "Disease progression ": 8.22606082815974, "Disease recurrence ": 2.617103535320575, "Drug resistance ": 2.057671630307007, "Ejection fraction decreased ": 19.65662482842396, "Enteritis ": 8.507164252657601, "Enterocolitis ": 5.291246879271678, "Eosinophil count decreased ": 10.163486851016634, "Febrile neutropenia ": 28.6039918549468, "Gastrointestinal necrosis ": 5.149910107105815, "Gastrointestinal toxicity ": 8.475191946069234, "Granulocyte count decreased ": 29.809336165949333, "Granulocytopenia ": 16.80505747082617, "HER2 positive breast cancer ": 60.21118480566387, "Haematotoxicity ": 16.664863617161, "Hair colour changes ": 10.752739606272568, "Hair texture abnormal ": 19.602769801409373, "Hepatic function abnormal ": 3.646807882703908, "Hepatic lesion ": 4.084418921600537, "Hormone-refractory prostate cancer ": 31.42073171900225, "Hypoalbuminaemia ": 3.427118686237361, "Hypocalcaemia ": 2.87736709661984, "Hypomagnesaemia ": 2.303911105122637, "Ileus paralytic ": 6.388616230068829, "Interstitial lung disease ": 4.070969174074145, "Intestinal obstruction ": 2.5208705875980018, "Invasive ductal breast carcinoma ": 6.918153166044202, "Lacrimation increased ": 2.313130989077009, "Large intestine perforation ": 4.969710625873473, "Left ventricular dysfunction ": 12.845707313435303, "Leukoencephalopathy ": 4.176121464472854, "Leukopenia ": 8.147973514141079, "Lower limb fracture ": 2.213641969034443, "Lung adenocarcinoma ": 14.324400832077291, "Lymphocyte count decreased ": 4.095361731196704, "Lymphopenia ": 2.9178734386698912, "Madarosis ": 28.634906865586395, "Malignant neoplasm progression ": 6.961275829144909, "Mastectomy ": 9.743275516649092, "Metastases to bone ": 18.209331432456565, "Metastases to central nervous system ": 9.551172068634004, "Metastases to liver ": 13.095444590288958, "Metastases to lung ": 15.80763441352502, "Metastases to lymph nodes ": 19.01086616611968, "Metastases to peritoneum ": 4.365230794928159, "Metastases to pleura ": 12.567505471785957, "Metastases to skin ": 18.2761915385294, "Metastases to spine ": 4.508553353777948, "Metastases to the mediastinum ": 46.6027442241182, "Metastasis ": 21.238099804132546, "Mouth ulceration ": 2.1575535697871917, "Mucosal inflammation ": 11.1819402652812, "Myelodysplastic syndrome ": 4.9583661044732095, "Myelosuppression ": 48.89011241487291, "Nail disorder ": 14.73465580338538, "Nasal disorder ": 13.998010511142423, "Neoplasm progression ": 3.9210568211633503, "Neoplasm recurrence ": 16.70196546036002, "Neuropathy peripheral ": 4.935840458630976, "Neurotoxicity ": 4.2277405777198, "Neutropenia ": 8.784217499544068, "Neutropenic colitis ": 23.721687015940727, "Neutropenic sepsis ": 7.723748318635585, "Neutrophil count decreased ": 34.6332450366487, "Neutrophil count increased ": 3.8817215350565952, "Non-small cell lung cancer ": 17.51882348616584, "Oesophagitis ": 3.056369699064993, "Onycholysis ": 18.73956889653857, "Osteonecrosis of jaw ": 3.952831959644103, "Palmar-plantar erythrodysaesthesia syndrome ": 4.53870810103801, "Paronychia ": 5.435922286220248, "Peripheral sensory neuropathy ": 4.271454127678446, "Peritonitis ": 2.2139518672388983, "Platelet count decreased ": 2.002123354832943, "Pleural effusion ": 3.3059096040541758, "Pneumatosis intestinalis ": 5.056969776330204, "Pneumocystis jirovecii pneumonia ": 2.5702896223938048, "Pneumonitis ": 2.8653892941791006, "Polyneuropathy ": 8.982403123324195, "Portal venous gas ": 56.987472475308735, "Prostate cancer ": 3.896826834079503, "Prostate cancer metastatic ": 32.343223176880564, "Prostatic specific antigen increased ": 15.151697270019106, "Pulmonary mass ": 2.9186407385575883, "Red cell distribution width increased ": 7.111332685901453, "Second primary malignancy ": 7.366515751135224, "Septic shock ": 3.840512063938932, "Skin toxicity ": 10.582405339649268, "Stomatitis ": 4.552268820396817, "Subacute cutaneous lupus erythematosus ": 9.68083023843458, "Subclavian vein thrombosis ": 36.335822128779775, "Systemic scleroderma ": 38.2202431150985, "Therapy partial responder ": 7.711904578613736, "Tongue ulceration ": 6.127561723515743, "Tonsillar disorder ": 36.672353537887865, "Troponin I increased ": 9.02382135245436, "Tumour lysis syndrome ": 3.306028825119776, "Uterine leiomyoma ": 3.559454552087941, "Uterine leiomyosarcoma ": 92.3979135954961, "Vascular device infection ": 4.413321136500792, "White blood cell count decreased ": 23.808916684689176, "White blood cell count increased ": 2.0993060115055737} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/354.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/354.json new file mode 100644 index 00000000000..037a0eba647 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/354.json @@ -0,0 +1 @@ +{"Atrial fibrillation ": 16.851594821294245, "Drug interaction ": 6.6909984777142135, "Electrocardiogram QT prolonged ": 38.93381479128505} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/355.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/355.json new file mode 100644 index 00000000000..3263701565f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/355.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 3.1330095999477057, "Aphasia ": 3.722706740607183, "Blood HIV RNA increased ": 161.48362298599707, "Condition aggravated ": 2.037388976246975, "Depressed level of consciousness ": 3.4339370663475286, "Drug interaction ": 2.4446326528610127, "Drug resistance ": 16.338730060176587, "Exposure during pregnancy ": 6.658141928916503, "Foetal exposure during pregnancy ": 6.160317009750506, "Foetal growth restriction ": 11.893823751249432, "Generalised tonic-clonic seizure ": 4.2633749946342725, "Gestational diabetes ": 33.81449259053695, "Hepatitis C ": 4.765148696447183, "Immune reconstitution inflammatory syndrome ": 203.1557820626649, "Immune reconstitution inflammatory syndrome associated tuberculosis ": 372.8722313325229, "Lactic acidosis ": 4.342632317561691, "Leukocytosis ": 6.986331431046132, "Live birth ": 10.904616724138082, "Liver injury ": 3.84765355622666, "Mental status changes ": 5.956877568247251, "Muscular weakness ": 2.306513241887995, "Nephropathy toxic ": 122.68740612527888, "Pancytopenia ": 2.3538100855586124, "Pathogen resistance ": 83.16547948207413, "Pericardial effusion ": 6.064657975868012, "Polyneuropathy ": 27.501523657553747, "Premature baby ": 5.612270060079436, "Progressive multifocal leukoencephalopathy ": 31.865709654787818, "Psychiatric symptom ": 29.68566372575558, "Renal disorder ": 3.6878288503511856, "Renal impairment ": 2.0599371832513715, "Renal tubular disorder ": 22.02158730724053, "Skin lesion ": 4.152409441463069, "Treatment noncompliance ": 28.696180028118555, "Viral load increased ": 25.150319199271856, "Viral mutation identified ": 183.7559197868926, "Virologic failure ": 213.4464445613229} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/356.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/356.json new file mode 100644 index 00000000000..28c29d1e555 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/356.json @@ -0,0 +1 @@ +{"Chondrolysis ": 83876.61688034111, "Musculoskeletal pain ": 599.3138099904689} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/357.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/357.json new file mode 100644 index 00000000000..0093978d029 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/357.json @@ -0,0 +1 @@ +{"Drug interaction ": 15.707486753813953, "Respiratory failure ": 15.2880695457815, "Sepsis ": 14.776321272538222} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/358.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/358.json new file mode 100644 index 00000000000..d3bca616224 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/358.json @@ -0,0 +1 @@ +{"Bronchial hyperreactivity ": 265.38219228543363, "Gait disturbance ": 2.645975776467828, "Product dose omission issue ": 5.932841394173069, "Suicidal ideation ": 4.502416794398693, "Weight increased ": 4.002128469983708, "Wheezing ": 6.495459550206273} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/359.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/359.json new file mode 100644 index 00000000000..347b4f44544 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/359.json @@ -0,0 +1 @@ +{"Acquired gene mutation ": 33.07876840221489, "Acute graft versus host disease ": 11.27876069501697, "Acute hepatic failure ": 7.77583781712053, "Acute lymphocytic leukaemia ": 6.604668079091947, "Acute myeloid leukaemia ": 11.517938374911369, "Acute promyelocytic leukaemia ": 22.85371684936645, "Agranulocytosis ": 8.878035913894303, "Alveolitis ": 87.17841772880637, "Anaemia ": 2.42120053817548, "Anti-Muellerian hormone level decreased ": 1003.0704904166596, "Aplastic anaemia ": 4.956175486850026, "Aspergillus infection ": 5.890724589947423, "Atrial fibrillation ": 2.465668338671068, "B-cell lymphoma ": 13.782308897792818, "B-cell lymphoma recurrent ": 86.78978224602395, "Bacteraemia ": 10.1551895804153, "Bicytopenia ": 23.31936433438412, "Blood follicle stimulating hormone increased ": 185.46856782293065, "Blood lactate dehydrogenase increased ": 4.7655335060127015, "Blood luteinising hormone increased ": 382.81432429938366, "Blood magnesium decreased ": 7.547550354952121, "Bone marrow failure ": 5.579113675177734, "Brain injury ": 2.690599529770381, "Brain oedema ": 4.177056157644085, "Bronchopulmonary aspergillosis ": 6.8681386893973855, "COVID-19 pneumonia ": 2.4565337170204247, "Cardiac failure ": 2.4277300173373115, "Cardiomyopathy ": 7.85212425884016, "Cardiotoxicity ": 21.588565504985556, "Central nervous system lymphoma ": 27.93473138313545, "Chemotherapy ": 24.95755586541064, "Chronic lymphocytic leukaemia recurrent ": 49.77560763297469, "Chronic myeloid leukaemia ": 5.427430558132807, "Clostridium difficile colitis ": 2.1838694768949174, "Clostridium difficile infection ": 3.1713530572825075, "Concomitant disease aggravated ": 3.822329859486565, "Congenital aplasia ": 10.629136231303564, "Cytokine release syndrome ": 5.501413541788695, "Cytomegalovirus chorioretinitis ": 9.996029640662906, "Cytomegalovirus infection ": 2.8757821022014247, "Cytomegalovirus infection reactivation ": 8.609450625438626, "Cytopenia ": 22.52108065990787, "Diffuse large B-cell lymphoma ": 34.81941064044349, "Diffuse large B-cell lymphoma recurrent ": 101.48669010949072, "Diffuse large B-cell lymphoma refractory ": 94.08617766340936, "Dilated cardiomyopathy ": 5.365205940480204, "Disease progression ": 10.28520337178969, "Disease recurrence ": 2.5475233043321355, "Drug resistance ": 2.046394853986681, "Ejection fraction decreased ": 5.2485025127004175, "Epstein-Barr virus infection reactivation ": 24.616525964638715, "Febrile bone marrow aplasia ": 14.738893388231258, "Febrile neutropenia ": 33.866760707716715, "Follicular lymphoma ": 60.85012272310657, "Gastrointestinal toxicity ": 5.511553625063246, "Granulocyte count decreased ": 34.600772447016915, "Granulocytopenia ": 22.54769059679511, "Haematotoxicity ": 7.817870414904575, "Haemoglobin decreased ": 2.874994168572329, "Haemophagocytic lymphohistiocytosis ": 3.5056478274243608, "Heart rate abnormal ": 6.062422331254474, "Hepatic failure ": 2.812731149240664, "Hepatic function abnormal ": 3.703434639682866, "Hepatitis B ": 29.3846056265272, "Hepatitis B reactivation ": 44.05824269346044, "Hepatitis fulminant ": 3.974093012982332, "Hodgkin's disease ": 8.221703260208425, "Hodgkin's disease recurrent ": 142.66811151216874, "Hormone level abnormal ": 18.69116421200922, "Hydronephrosis ": 5.047385593986239, "Hypogammaglobulinaemia ": 7.427778595904688, "Hypoxia ": 5.066251683724025, "Immune effector cell-associated neurotoxicity syndrome ": 11.979266060860573, "Immune-mediated adrenal insufficiency ": 10.378304862037805, "Inappropriate antidiuretic hormone secretion ": 2.170291675945544, "Infection ": 3.125625815851294, "Interstitial lung disease ": 7.142306990121552, "Left ventricular dysfunction ": 3.170162348835011, "Leukaemia ": 3.910483703794333, "Leukopenia ": 7.36564386485423, "Lymphadenitis ": 3.1089365297771447, "Lymphocyte count decreased ": 7.865678461439518, "Lymphoma ": 2.988285940887218, "Lymphopenia ": 4.208275759679525, "Malignant neoplasm progression ": 2.241303624174718, "Mucosal inflammation ": 6.448123299390503, "Multiple organ dysfunction syndrome ": 2.420876958207874, "Myelodysplastic syndrome ": 8.745734145159718, "Myelosuppression ": 44.27675282111058, "Neoplasm progression ": 5.393891934457058, "Neuropathy peripheral ": 2.9444090404821277, "Neutropenia ": 7.811220037767547, "Neutropenic sepsis ": 18.021746827221516, "Neutrophil count decreased ": 25.98514192103382, "Neutrophil count increased ": 3.476272047505969, "Night sweats ": 2.237001474630656, "No adverse event ": 2.1329943953204333, "Non-Hodgkin's lymphoma ": 6.806077024869822, "Oestradiol decreased ": 464.68485732743153, "Off label use ": 2.944403988934603, "Pancytopenia ": 7.601580795610622, "Papilloedema ": 8.555582261201163, 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of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/363.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/363.json new file mode 100644 index 00000000000..c24b4f2426b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/363.json @@ -0,0 +1 @@ +{"Asthenia ": 2.578260237827025, "Feeling abnormal ": 4.188819983194419, "Gastritis ": 29.63207932518932, "Urticaria ": 3.872641258125325} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/364.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/364.json new file mode 100644 index 00000000000..4ce413fbe60 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/364.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.7440667201091835, "Blood glucose abnormal ": 19.629489300989093, "Blood glucose decreased ": 30.379715554242512, "Blood 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2.0879347173852185, "Urine odour abnormal ": 14.264191576187356, "Weight increased ": 2.663389281221831, "Wrong patient ": 37.16188634865584} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/366.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/366.json new file mode 100644 index 00000000000..984a52d80b0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/366.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 10.280441326272848, "Anaemia ": 14.75399969677695, "Cerebral haemorrhage ": 12.375280399412684, "Epistaxis ": 9.883986237489244, "Gastrointestinal haemorrhage ": 10.826895796243075, "Haematoma ": 10.158495994559376, "Hyperkalaemia ": 19.34434890240969, "Lactic acidosis ": 35.72516020539575, "Melaena ": 19.36354366868858, "Rectal haemorrhage ": 18.933622390184794} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/367.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/367.json new file mode 100644 index 00000000000..aaadfffa12b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/367.json @@ -0,0 +1 @@ +{"Asthma ": 14.38718825501912, "Chest discomfort ": 2.563358349095402, "Chronic obstructive pulmonary disease ": 11.451790987034324, "Condition aggravated ": 4.789880979388072, "Cough ": 5.89189519647757, "Device malfunction ": 29.951979733903997, "Drug ineffective ": 2.7178788020114344, "Dysphonia ": 15.472144797166589, "Dyspnoea ": 5.28626974991273, "Muscle spasms ": 8.956379816784567, "Oral candidiasis ": 16.35545172849498, "Oropharyngeal pain ": 6.5982924514366985, "Palpitations ": 2.491452297440771, "Product quality issue ": 24.653601987947177, "Product substitution issue ": 100.00162811000044, "Therapeutic product effect incomplete ": 3.9154178181483377, "Therapeutic response unexpected ": 19.4351307566344, "Tremor ": 3.146140616221603, "Wheezing ": 5.809949516841132} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/368.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/368.json new file mode 100644 index 00000000000..5003fddf8f2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/368.json @@ -0,0 +1 @@ +{"Pemphigoid ": 440.691716296677} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/369.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/369.json new file mode 100644 index 00000000000..465f52bc4b9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/369.json @@ -0,0 +1 @@ +{"Asthma ": 5.484930631895915, "Chest discomfort ": 2.332590888266992, "Dermatitis atopic ": 151.26746399987078, "Eosinophil count increased ": 29.744665725515546, "Gestational hypertension ": 532.0404063831385, "Infection ": 3.591200522643096, "Maternal exposure before pregnancy ": 155.54580913172757, "Maternal exposure during pregnancy ": 6.654305319862672, "Premature delivery ": 52.25794809196569, "Steroid diabetes ": 586.56256011252} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/37.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/37.json new file mode 100644 index 00000000000..da206672577 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/37.json @@ -0,0 +1 @@ +{"Blood pressure increased ": 6.42932868638543, "Heart rate increased ": 9.13627834487562, "Infusion related reaction ": 17.317630442395497} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/370.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/370.json new file mode 100644 index 00000000000..912299d043c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/370.json @@ -0,0 +1 @@ +{"Asthma ": 8.733155971240059, "Bronchitis ": 2.687965300865257, "Cataract ": 7.502553720239467, "Cellulitis ": 3.070157786095242, "Chest discomfort ": 2.4467281931639677, "Cough ": 2.280601079264091, "Dermatitis atopic ": 59.5831003354255, "Drug hypersensitivity ": 5.401512033901239, "Dry eye ": 5.376112115363782, "Dry skin ": 5.382447301237019, "Eczema ": 3.694088681694117, "Eosinophil count increased ": 16.1346065222669, "Eosinophilia ": 4.676493960660832, "Eye disorder ": 4.414523749454035, "Eye infection ": 54.53690993932045, "Eye pain ": 4.082846102819229, "Full blood count abnormal ": 3.3888005614164407, "Hospitalisation ": 5.066538717516255, "Illness ": 3.634660844363245, "Infection ": 2.070912006595261, "Loss of personal independence in 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/375.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/375.json new file mode 100644 index 00000000000..8b274e9d7ec --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/375.json @@ -0,0 +1 @@ +{"BK virus infection ": 149.3936424243999, "Foetal exposure during pregnancy ": 7.827990452198647, "Fungal peritonitis ": 1916.125622920623, "Live birth ": 48.0223760262891, "Off label use ": 4.999771701566923, "Peritonitis ": 41.09252560238984, "Premature baby ": 25.52749024781719, "Respiratory failure ": 8.026258961254051, "Sepsis ": 10.895298941351989, "Systemic candida ": 218.76541966221316, "Thrombocytopenia ": 2.062031435991037, "Thrombotic microangiopathy ": 112.3892235278637, "Treatment failure ": 7.548694838418296} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/376.json 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--- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/378.json @@ -0,0 +1 @@ +{"Depression ": 3.063189597258597, "Drug resistance ": 8.947842229864875, "Dyspepsia ": 3.1275379498560065, "Exposure during pregnancy ": 3.3250774665221727, "Foetal exposure during pregnancy ": 3.931458941239691, "Glomerular filtration rate decreased ": 27.643554080405792, "Hyperlipidaemia ": 29.80580741826289, "Liver disorder ": 7.24168984015721, "Nightmare ": 12.394255766578366, "Renal impairment ": 2.7104834575506547, "Sleep disorder ": 10.351067834230673, "Vertigo ": 3.7775212085415726} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/379.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/379.json new file mode 100644 index 00000000000..df01140217c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/379.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 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increased ": 26.47656970226932, "Viral mutation identified ": 62.81485457310976, "Virologic failure ": 100.4913544220476} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/38.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/38.json new file mode 100644 index 00000000000..a644182aff7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/38.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 8.297007844238493, "Aspartate aminotransferase increased ": 9.483824023165434, "Blood bilirubin increased ": 18.615332890126915, "Blood creatinine increased ": 8.397804156873724, "Lactic acidosis ": 18.69573347936737} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/380.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/380.json new file mode 100644 index 00000000000..cad357fbcd2 --- 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/382.json @@ -0,0 +1 @@ +{"Acute myocardial infarction ": 9.723389847598872, "Anaemia ": 5.0896471017655225, "Angina pectoris ": 7.759070931834747, "Angina unstable ": 30.02469311537381, "Atrial fibrillation ": 2.0732537521342174, "Blood loss anaemia ": 16.77769326125134, "Blood pressure decreased ": 2.465205843994158, "Cardiac tamponade ": 35.57768761718435, "Cerebellar haemorrhage ": 38.11089996078156, "Cerebral haematoma ": 17.185782528429502, "Cerebral haemorrhage ": 26.87872470910498, "Cerebral infarction ": 10.28740006696944, "Cholecystitis ": 8.970764776553374, "Contusion ": 2.8768384125875177, "Coronary artery restenosis ": 215.6312444510972, "Coronary artery stenosis ": 38.20466029815059, "Device occlusion ": 21.232012085761024, "Diverticulum intestinal haemorrhagic ": 98.73199944516794, "Drug eruption ": 3.514184810299948, "Drug interaction ": 2.087939270488199, "Duodenal ulcer haemorrhage ": 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/383.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/383.json new file mode 100644 index 00000000000..25cd30354f8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/383.json @@ -0,0 +1 @@ +{"Asthenia ": 11.8498517621964, "Herpes zoster ": 8.16818884785346, "Immunisation reaction ": 36.530906969268365, "Influenza like illness ": 2.613017390762926, "Interchange of vaccine products ": 31.434959645299845, "Vaccination site pain ": 2.883699324443119, "Vaccination site reaction ": 5.808806897481141} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/384.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/384.json new file mode 100644 index 00000000000..b471fd96b36 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/384.json @@ -0,0 +1 @@ +{"Therapy non-responder ": 381.91282480365993} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/385.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/385.json new file mode 100644 index 00000000000..3a29a799da2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/385.json @@ -0,0 +1 @@ +{"Cough ": 10.489308826295764, "Throat irritation ": 31.089914454059905} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/386.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/386.json new file mode 100644 index 00000000000..f60eb7f5c26 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/386.json @@ -0,0 +1 @@ +{"Abdominal wall haematoma ": 7.293286651830681, "Abdominal wall haemorrhage ": 6.592813849834514, "Accident ": 3.530857527375631, "Acquired 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7.422517329871476, "Aortic valve stenosis ": 6.475274421695546, "Appendix disorder ": 3.290783196566647, "Arterial disorder ": 2.2091494959624507, "Arterial haemorrhage ": 10.049142472550706, "Arterial occlusive disease ": 2.104698133368001, "Arterial thrombosis ": 5.641196238041681, "Arteriovenous malformation ": 4.370350849036751, "Arthropathy ": 3.3169195186283607, "Aspiration pleural cavity ": 7.614443614580375, "Atheroembolism ": 12.510169212244046, "Atrial fibrillation ": 8.619192447603272, "Atrial flutter ": 3.943571338935379, "Atrial thrombosis ": 74.41860959711089, "Atrophic vulvovaginitis ": 5.380549696214997, "Back disorder ": 4.283560731257727, "Basal ganglia haemorrhage ": 41.59817321592445, "Benign prostatic hyperplasia ": 3.546436855125705, "Bladder catheterisation ": 3.259793871613891, "Bladder neoplasm ": 6.876427731048126, "Bladder operation ": 3.725319392458172, "Bladder tamponade ": 13.003589631100738, "Bleeding time prolonged ": 6.346513599081914, "Bleeding varicose vein ": 16.938764198578106, "Blood blister ": 4.001715132464055, "Blood creatinine abnormal ": 3.74005847984047, "Blood disorder ": 3.0479205858603358, "Blood iron decreased ": 3.288142790445019, "Blood loss anaemia ": 11.635155061163964, "Blood pressure diastolic abnormal ": 2.531849946363495, "Blood pressure systolic abnormal ": 2.17246954803393, "Blood test abnormal ": 3.171667260432708, "Blood urine present ": 10.853187012113892, "Blood viscosity increased ": 7.758519755910308, "Blue toe syndrome ": 3.396716618375932, "Body height decreased ": 5.262931215666815, "Bone cancer ": 2.2308208229308137, "Brain contusion ": 10.581484980839774, "Brain herniation ": 4.3666983739358765, "Brain neoplasm malignant ": 2.7893527163695637, "Brain stem haemorrhage ": 26.52218687800658, "Breast disorder ": 2.585098252771314, "Breast haematoma ": 7.623431057954024, "Breast haemorrhage ": 8.581724377887467, "Bronchial haemorrhage ": 6.169749691736408, "Bronchial secretion retention ": 4.551385417220312, "Bronchial wall thickening ": 5.157981976522295, "COVID-19 pneumonia ": 2.326858853898657, "Calculus bladder ": 5.909672674219296, "Cancer surgery ": 3.3417155198641377, "Cardiac ablation ": 18.2849970108985, "Cardiac amyloidosis ": 5.498799956298751, "Cardiac disorder ": 10.864253896064886, "Cardiac failure ": 3.131069201716865, "Cardiac failure acute ": 2.725192913895552, "Cardiac failure chronic ": 3.017735585212816, "Cardiac failure congestive ": 3.188745472850586, "Cardiac fibrillation ": 4.022691021758137, "Cardiac flutter ": 2.191255687269185, "Cardiac pacemaker insertion ": 11.066822507884291, "Cardiac tamponade ": 6.629846756264094, "Cardiac valve disease ": 13.090848354012389, "Cardiac ventricular thrombosis ": 13.482786689681452, "Cardioversion ": 30.37698521905501, "Carotid arteriosclerosis ": 2.514351555136754, "Carotid artery disease ": 4.375704885111605, "Carotid artery occlusion ": 2.297783335098017, "Carotid artery stenosis ": 3.1535009726382546, "Carpal tunnel syndrome ": 4.060750994182974, "Cataract ": 2.570693854505259, "Catheter placement ": 3.1776154255171325, "Catheter site haemorrhage ": 7.475241684036214, "Catheterisation cardiac ": 2.246324974374478, "Cell death ": 2.001161259931424, "Cerebellar haematoma ": 17.679380060402934, "Cerebellar haemorrhage ": 30.256845225856573, "Cerebellar infarction ": 5.906671324338264, "Cerebral amyloid angiopathy ": 6.849158639178266, "Cerebral artery embolism ": 20.343399673502446, "Cerebral artery occlusion ": 3.0181532396157995, "Cerebral haematoma ": 27.025039422845364, "Cerebral haemorrhage ": 24.782486016188862, "Cerebral infarction ": 13.78564970797908, "Cerebral ischaemia ": 3.2106964201826576, "Cerebral mass effect ": 10.679118677352198, "Cerebral microhaemorrhage ": 7.738648184013976, "Cerebral small vessel ischaemic disease ": 2.846693043746406, "Cerebral thrombosis ": 3.254039370289824, "Cerebral ventricular rupture ": 60.58876673469882, "Cerebrovascular accident ": 10.303969557837297, "Cerebrovascular disorder ": 2.1666553019584005, "Cervical vertebral fracture ": 4.371814168631916, "Cholestatic liver injury ": 2.4255276601571154, "Chronic left ventricular failure ": 10.640130447044134, "Circumstance or information capable of leading to medication error ": 5.050222890493761, "Coagulation factor V level abnormal ": 15.08833991582244, "Colon cancer ": 4.291847697780801, "Colon neoplasm ": 4.714050053360888, "Compartment syndrome ": 3.5677503490303475, "Conjunctival haemorrhage ": 8.348533677429831, "Contusion ": 4.314768878041203, "Craniocerebral injury ": 2.15538603184477, "Craniofacial fracture ": 2.3928531506801227, "Craniotomy ": 33.93874012961033, "Creatinine renal clearance abnormal ": 9.627683228623953, "Cutaneous vasculitis ": 2.325476273167107, "Death ": 2.146146171531744, "Deep vein thrombosis ": 6.079256972686195, "Dementia ": 6.967471757484527, "Dementia Alzheimer's type ": 5.524412585524457, "Dental care ": 5.710555313068394, "Dental operation ": 4.457816363781606, "Device related thrombosis ": 3.197149907745068, "Diastolic dysfunction ": 2.8708311437213574, "Dieulafoy's vascular malformation ": 10.919531897994723, "Diverticulitis intestinal haemorrhagic ": 14.210089769804812, "Diverticulum ": 2.240109254684085, "Diverticulum intestinal haemorrhagic ": 33.00622663968115, "Duodenal ulcer ": 3.8330296984956895, "Duodenal ulcer haemorrhage ": 5.812450062267315, "Dyschezia ": 2.2880939456429297, "Ear congestion ": 2.247412164230413, "Ear haemorrhage ": 12.704485505650254, "Ecchymosis ": 2.61792284215252, "Ejection fraction ": 3.968887028947694, "Ejection fraction abnormal ": 6.503314460189596, "Elephantiasis ": 36.11920507529975, "Embolic cerebral infarction ": 12.265326190051605, "Embolic stroke ": 48.89697717426432, "Embolism ": 5.629646065321832, "Embolism arterial ": 4.461745988823241, "Embolism venous ": 10.94544583467757, "Endocarditis noninfective ": 21.841272133949232, "Epidural haemorrhage ": 17.191654366998073, "Epistaxis ": 10.054806126937931, "Essential hypertension ": 2.7015006697822392, "Extradural haematoma ": 13.029187238033831, "Eye contusion ": 3.0756714839623074, "Eye disorder ": 2.486244237740256, "Eye haematoma ": 4.417189613743751, "Eye haemorrhage ": 11.313018125307648, "Face injury ": 2.129853767681076, "Faeces discoloured ": 6.109531738890694, "Failure to suspend medication ": 159.78187428899716, "Fall ": 4.548622959575362, "Femoral neck fracture ": 2.570256929898922, "Femur fracture ": 2.068177423261455, "Food interaction ": 2.106821336923653, "Foreign body ": 6.773449635607992, "Gallbladder disorder ": 3.4842369177734325, "Gamma-glutamyltransferase abnormal ": 3.933919987423834, "Gastric antral vascular ectasia ": 5.442689839722771, "Gastric haemorrhage ": 11.68614236482202, "Gastric ulcer ": 3.9705309077916944, "Gastric ulcer haemorrhage ": 8.478055216677836, "Gastritis erosive ": 2.71242916780463, "Gastritis haemorrhagic ": 4.746200922300627, "Gastrointestinal angiodysplasia ": 8.310503277044662, "Gastrointestinal haemorrhage ": 18.527345941885574, "Gastrointestinal polyp ": 18.791516240245475, "Gastrointestinal polyp haemorrhage ": 16.839176470809043, "Gastrointestinal tube insertion ": 6.065023838259913, "Gastrointestinal ulcer haemorrhage ": 17.486244908525382, "Gastrointestinal vascular malformation haemorrhagic ": 7.456898994754625, "Gastrostomy ": 5.708181425065748, "Genital haemorrhage ": 4.263292680672584, "Gingival bleeding ": 8.81681994686775, "Glioblastoma ": 2.32722122478057, "Gout ": 2.4274453535780136, "Haemarthrosis ": 8.364239985396967, "Haematemesis ": 5.286726837040084, "Haematochezia ": 6.178089556178612, "Haematoma ": 9.631491425366338, "Haematoma evacuation ": 34.913481656251, "Haematoma muscle ": 12.607735570857788, "Haematospermia ": 3.9188670101785488, "Haematuria ": 10.86217903547569, "Haemobilia ": 9.057287006545344, "Haemoglobin abnormal ": 2.817907864919251, "Haemoglobin decreased ": 3.931341972396147, "Haemoperitoneum ": 6.185539797605499, "Haemoptysis ": 6.262239185797077, "Haemorrhage ": 17.798524805912308, "Haemorrhage intracranial ": 32.474074870565154, "Haemorrhage subcutaneous ": 27.84313481040556, "Haemorrhage urinary tract ": 14.868732934547223, "Haemorrhagic cerebral infarction ": 27.942138335375837, "Haemorrhagic diathesis ": 10.86553708568885, "Haemorrhagic disorder ": 13.454808682038507, "Haemorrhagic hepatic cyst ": 42.25727010196169, "Haemorrhagic infarction ": 23.964531344603422, "Haemorrhagic stroke ": 23.605829252793217, "Haemorrhagic transformation stroke ": 16.532783812562613, "Haemorrhoidal haemorrhage ": 20.2293577897148, "Haemorrhoids ": 2.844159977369024, "Haemostasis ": 31.158359845470763, "Haemothorax ": 11.743825285805633, "Head injury ": 5.419359569605819, "Heart valve incompetence ": 4.297966259728445, "Heart valve replacement ": 7.882346610854357, "Helicobacter test positive ": 2.877076278470465, "Hemiparesis ": 2.3362342165037644, "Hemiplegia ": 2.4879808466369853, "Hepatic haemorrhage ": 7.110144150968395, "Hernia ": 3.568909457307575, "High frequency ablation ": 57.879488600570006, "Hip fracture ": 4.269053421002841, "Hospitalisation ": 4.297572012549787, "Hydrocephalus ": 2.1295312568348383, "Hypercoagulation ": 4.321149540026172, "Hypoacusis ": 2.0059797098908456, "Hypovolaemic shock ": 2.744189813199186, "Idiopathic interstitial pneumonia ": 9.396406832254192, "Implant site haemorrhage ": 15.21130207721149, "Inability to afford medication ": 2.6179181648591188, "Incision site haemorrhage ": 14.804861072022629, "Increased tendency to bruise ": 3.824710492078796, "Infarction ": 4.044953239724482, "Infrequent bowel movements ": 2.1000561080311195, "Infusion site haemorrhage ": 11.553040939302468, "Inguinal hernia ": 2.6250916000960345, "Intentional product use issue ": 12.30260033786641, "Intentional underdose ": 3.2489984699311987, "Internal haemorrhage ": 35.661988071516724, "International normalised ratio abnormal ": 3.566632118801942, "International normalised ratio fluctuation ": 3.6049734275225735, "Intestinal haemorrhage ": 13.467533117786372, "Intestinal polyp ": 3.3087692493811622, "Intra-abdominal haematoma ": 3.622259578048948, "Intra-abdominal haemorrhage ": 9.44721658955165, "Intracranial aneurysm ": 4.286797686934121, "Intracranial haematoma ": 14.808275286788692, "Intraventricular haemorrhage ": 18.22659708926494, "Iron deficiency anaemia ": 5.350726431493227, "Ischaemia ": 2.076278699212947, "Ischaemic cerebral infarction ": 4.971902340279449, "Ischaemic stroke ": 14.237270524511388, "Joint injury ": 2.045641108151069, "Labelled drug-drug interaction medication error ": 3.0008960257388377, "Lacunar infarction ": 2.077785978298765, "Laparotomy ": 2.677067177231682, "Large intestinal haemorrhage ": 18.398287938529457, "Large intestine polyp ": 3.26668915874244, "Laryngeal haemorrhage ": 18.36423744601053, "Limb injury ": 3.268037144614117, "Limb mass ": 2.7097724360430706, "Loose tooth ": 2.203686274414696, "Lower gastrointestinal haemorrhage ": 16.645373803810696, "Lower limb fracture ": 2.214796992671167, "Lung cancer metastatic ": 4.466800069677869, "Lung carcinoma cell type unspecified stage IV ": 4.785078586457598, "Lung neoplasm malignant ": 2.7448782764379063, "Macular degeneration ": 2.644889694056368, "Mallory-Weiss syndrome ": 4.41867178875727, "Melaena ": 12.89642416117359, "Meningorrhagia ": 10.418608019474334, "Meniscus injury ": 2.5984031762032744, "Mesothelioma ": 12.511508345070762, "Microcytic anaemia ": 4.40117027565731, "Middle cerebral artery stroke ": 12.256099977060725, "Mineral supplementation ": 9.854581840918367, "Mitral valve disease ": 10.502652934576904, "Mitral valve incompetence ": 2.535094015418429, "Mitral valve stenosis ": 4.69058633009984, "Mixed liver injury ": 2.578424413578431, "Mouth haemorrhage ": 7.591971987547864, "Muscle haemorrhage ": 13.860986286403415, "Muscle rupture ": 2.366332459798268, "N-terminal prohormone brain natriuretic peptide increased ": 3.2214260905396137, "Neoplasm ": 2.680417327949972, "Neoplasm malignant ": 5.24066595545308, "Neovascular age-related macular degeneration ": 4.136404561931448, "Nephrectomy ": 4.948545414892426, "Neurologic neglect syndrome ": 3.0974762050922178, "No adverse event ": 4.334242680302658, "Obstruction ": 3.5526240057503102, "Occult blood ": 18.33089033289348, "Occult blood positive ": 5.931428761155782, "Oesophageal disorder ": 2.9281528325634967, "Oesophageal haemorrhage ": 7.472711899787304, "Oesophageal ulcer haemorrhage ": 5.317679950065124, "Ophthalmic vein thrombosis ": 3.165873003655279, "Ovarian vein thrombosis ": 26.51688724578051, "Paraplegia ": 2.450934675190487, "Pelvic fracture ": 2.14136273154322, "Pelvic haematoma ": 8.44189979001699, "Pelvic venous thrombosis ": 2.2388169361472903, "Penile haemorrhage ": 8.350988172112316, "Peptic ulcer ": 2.7015006697822392, "Peptic ulcer haemorrhage ": 4.346921126301893, "Percutaneous coronary intervention ": 15.628145133870683, "Pericardial drainage ": 12.970036131262283, "Pericardial haemorrhage ": 25.05009917101124, "Periorbital haematoma ": 11.159269012890167, "Peripheral arterial occlusive disease ": 2.7651290733313423, "Peripheral artery occlusion ": 2.096004366600632, "Peripheral artery thrombosis ": 3.649051938326524, "Peripheral embolism ": 6.739992436345964, "Petechiae ": 2.1587102200507315, "Pharyngeal haemorrhage ": 13.014032694093794, "Platelet transfusion ": 2.6949095395854026, "Polycystic ovaries ": 10.078486062131432, "Polyp ": 5.673721214840196, "Polypectomy ": 13.864676096176977, "Post procedural haematoma ": 14.607861096484418, "Post procedural haematuria ": 32.98303914682567, "Post procedural haemorrhage ": 24.00538431564614, "Post procedural infection ": 2.4896543912600486, "Postoperative thrombosis ": 14.262714572506985, "Prescribed overdose ": 4.478169672840556, "Prescribed underdose ": 55.06955722708253, "Procedural haemorrhage ": 19.312829696576863, "Product blister packaging issue ": 4.029400366951027, "Product label issue ": 3.4804982310872354, "Product packaging quantity issue ": 5.091454360551792, "Product prescribing error ": 2.323487921278806, "Prostatic disorder ": 8.282018900741669, "Prostatic haemorrhage ": 22.28347239732169, "Prostatic operation ": 7.162743490236901, "Prostatomegaly ": 2.423047796323768, "Prothrombin time ratio increased ": 6.149256689058482, "Prothrombin time shortened ": 3.1047072311038444, "Pulmonary alveolar haemorrhage ": 7.392505885164575, "Pulmonary embolism ": 5.046316190752374, "Pulmonary haemorrhage ": 5.989129532778697, "Pulmonary sepsis ": 3.946128878443052, "Pulmonary thrombosis ": 7.269941104295416, "Pulpitis dental ": 3.1498690574462844, "Puncture site haemorrhage ": 6.5223287080144505, "Purpura ": 2.1583919059620293, "Putamen haemorrhage ": 40.70555012857368, "Rectal cancer ": 3.4518961855279464, "Rectal haemorrhage ": 10.785926597124416, "Rectal ulcer haemorrhage ": 12.145510667586628, "Red blood cell transfusion ": 29.079301342660955, "Renal disorder ": 3.790555560394984, "Renal function test abnormal ": 2.2595473778868884, "Renal haematoma ": 6.94316828208914, "Renal haemorrhage ": 16.144603610326744, "Renal impairment ": 2.719072584125228, "Renal infarct ": 4.134741684747003, "Retinal haemorrhage ": 4.072032575720949, "Retroperitoneal haematoma ": 6.36052257700616, "Retroperitoneal haemorrhage ": 5.047299853825314, "Rhinitis allergic ": 3.077997175193168, "Scleral haemorrhage ": 12.977926372590542, "Scratch ": 2.570183969435943, "Seborrhoeic keratosis ": 2.9486444982725044, "Senile dementia ": 5.744455454513274, "Sensitisation ": 9.416322588777582, "Shock haemorrhagic ": 11.31341028150465, "Single functional kidney ": 7.744050743390675, "Sinus node dysfunction ": 2.04756402481731, "Skin cancer ": 2.2377037970151403, "Skin haemorrhage ": 6.655293447088898, "Skin laceration ": 7.685870144808694, "Skull fracture ": 3.237891432385267, "Sleep apnoea syndrome ": 2.977148651437226, "Small intestinal haemorrhage ": 12.762960317976765, "Soft tissue haemorrhage ": 7.846142889654954, "Spinal cord haematoma ": 9.835001037496006, "Spinal cord haemorrhage ": 32.358945230425725, "Spinal disorder ": 3.9220149930677817, "Spinal epidural haematoma ": 4.989587882126978, "Splenic haemorrhage ": 15.90512194039946, "Splenic rupture ": 2.7864925027583625, "Spontaneous haematoma ": 7.958096271270964, "Spontaneous haemorrhage ": 17.844688464183093, "Stent placement ": 3.53926434615937, "Stoma site haemorrhage ": 9.091236336200415, "Stress fracture ": 2.894468028928482, "Subarachnoid haemorrhage ": 13.096167844270582, "Subcapsular renal haematoma ": 8.440257728738448, "Subcutaneous haematoma ": 7.735414207091756, "Subdural haematoma ": 19.38551091233124, "Subdural haemorrhage ": 15.214601432025654, "Surgery ": 6.009813090301468, "Tachyarrhythmia ": 2.4097213627170437, "Thalamic infarction ": 3.595917180351547, "Thalamus haemorrhage ": 53.66809023908258, "Throat cancer ": 2.149237577734681, "Thrombectomy ": 22.09944585424404, "Thrombosis ": 9.98676141062094, "Thrombotic stroke ": 6.0205948439706285, "Tongue haemorrhage ": 3.757013504805918, "Tongue neoplasm malignant stage unspecified ": 2.584740837872284, "Tooth disorder ": 19.487095391863605, "Tooth extraction ": 4.15772237659085, "Tooth fracture ": 2.1749403755582746, "Transfusion ": 21.28666246514373, "Transient ischaemic attack ": 7.192627051920292, "Traumatic fracture ": 9.325613116241495, "Traumatic haematoma ": 16.849723981364953, "Traumatic haemorrhage ": 30.623982985903854, "Traumatic haemothorax ": 16.538672437917782, "Traumatic intracranial haemorrhage ": 33.0706713745353, "Traumatic lung injury ": 2.642901775686463, "Treatment noncompliance ": 5.873318441099286, "Tumour haemorrhage ": 8.457901856553727, "Ulcer ": 2.1132407000417364, "Ulcer haemorrhage ": 4.852543782694105, "Upper gastrointestinal haemorrhage ": 7.755502830533035, "Urethral haemorrhage ": 16.399142436691708, "Urinary bladder haemorrhage ": 33.31290169044828, "Urogenital haemorrhage ": 13.78863235625374, "Uterine disorder ": 6.6627138568353725, "Uterine haemorrhage ": 2.8074527204748803, "Vaginal haemorrhage ": 2.139822364305374, "Varicose vein ": 3.8188055604719646, "Vascular cauterisation ": 42.25727010196169, "Vascular occlusion ": 2.5828577298352, "Vascular pseudoaneurysm ": 3.310441291262918, "Vascular purpura ": 3.423264069837594, "Vascular rupture ": 3.6853321938930974, "Vein disorder ": 2.595433906201764, "Vein rupture ": 4.854529351873127, "Vena cava thrombosis ": 2.5274133666166225, "Venous haemorrhage ": 7.08937327381996, "Venous thrombosis ": 2.6543583594522384, "Ventricular drainage ": 50.95462680899003, "Vitreous haemorrhage ": 5.618321305395564, "Weight abnormal ": 3.867949920595654, "Weight fluctuation ": 4.857622923340889, "Wound haemorrhage ": 26.669319047637, "Wrong dose ": 2.002012907756609, "Wrong patient received product ": 3.717334093272944, "Wrong technique in product usage process ": 2.305527318333674} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/387.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/387.json new file mode 100644 index 00000000000..49431d3fb83 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/387.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.9974849293112027, "Abdominal distension ": 6.230438585629753, "Abdominal pain ": 6.274121313703742, "Abdominal pain lower ": 29.46956243178612, "Abdominal pain upper ": 3.0368345967082138, "Abortion induced ": 131.69229441514122, "Abortion spontaneous ": 11.008724546845963, "Acne ": 8.076129688567814, "Adnexa uteri pain ": 43.08668577799354, "Amenorrhoea ": 2.275766905749496, "Appetite disorder ": 9.00152179985779, "Back pain ": 2.480527595472175, "Breast discomfort ": 58.53795787571606, "Breast pain ": 21.78240385878443, "Breast swelling ": 24.15111959547352, "Breast tenderness ": 35.05443348359041, "Depressed mood ": 2.4627070456965297, "Diarrhoea ": 2.8705250141867067, "Disturbance in attention ": 2.3586285730297303, "Drug ineffective ": 4.230885789253019, "Dry mouth ": 2.5397258692379583, "Dysmenorrhoea ": 4.680213937965393, "Ectopic pregnancy ": 92.73931409255113, "Emotional disorder ": 4.808722830383373, "Exposure during pregnancy ": 2.68154424489079, "Exposure via breast milk ": 6.543293460583357, "Flatulence ": 3.811313689249257, "Heavy menstrual bleeding ": 4.733054172327333, "Hot flush ": 4.228055623300692, "Hypomenorrhoea ": 59.68453358266352, "Inappropriate schedule of product administration ": 6.445725806671893, "Increased appetite ": 5.277451658542609, "Intermenstrual bleeding ": 6.011288323229672, "Labelled drug-drug interaction medication error ": 5.507525391582116, "Menstrual disorder ": 2.977724608827629, "Menstruation delayed ": 84.35303207001584, "Menstruation irregular ": 2.1522009742812838, "Mood 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": 4.40874978521634, "Weight decreased ": 2.26619573459899, "Weight increased ": 4.625625762765139} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/390.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/390.json new file mode 100644 index 00000000000..f4f462d84a3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/390.json @@ -0,0 +1 @@ +{"Ovarian hyperstimulation syndrome ": 1163.225652223502} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/391.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/391.json new file mode 100644 index 00000000000..878d0fa1f59 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/391.json @@ -0,0 +1 @@ +{"Anaemia ": 2.634889364068919, "Bone marrow failure ": 44.31260794340105, "Cachexia ": 109.45748141842796, "Drug 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5.030237175374499, "Anaphylactic shock ": 2.1454589944833344, "Aspartate aminotransferase increased ": 2.316588152999061, "Aspiration ": 8.572635537133758, "Blood albumin decreased ": 11.072762026873674, "Blood chloride decreased ": 33.369018037201094, "Blood magnesium decreased ": 14.809533992840915, "Blood sodium decreased ": 4.766771884988119, "Blood urea decreased ": 52.37347235055133, "Blood urea increased ": 2.7560912039608323, "Bone marrow failure ": 8.81581645064908, "Bronchopulmonary aspergillosis ": 12.45973788943276, "Cholestasis ": 4.9458198199253, "Congenital aplasia ": 27.7043105783278, "Constipation ": 2.148383724398482, "Death ": 2.8770921260801754, "Dermatitis bullous ": 21.364570214093018, "Dermatitis exfoliative generalised ": 6.2066133312875165, "Dermatitis infected ": 188.61368844580625, "Drug eruption ": 3.061240749645224, "Drug interaction ": 2.641515649050951, "Dysphagia ": 4.705210760438708, "Encephalopathy ": 35.7531092545134, "Erythema ": 4.53597422504212, 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infection ": 846.56413802355, "Postural orthostatic tachycardia syndrome ": 622.6024985866085} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/394.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/394.json new file mode 100644 index 00000000000..748142d91b3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/394.json @@ -0,0 +1 @@ +{"Drug specific antibody present ": 540.4426166802308, "Haemarthrosis ": 371.1927162278088, "Haemorrhage ": 14.55526280144404, "Head injury ": 40.897408721612, "Muscle haemorrhage ": 222.32659432783367, "Off label use ": 2.354539991363728} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/395.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/395.json new file mode 100644 index 00000000000..4af228a9cf1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/395.json @@ -0,0 +1 @@ +{"Abnormal loss of weight ": 8.097988738803862, "Acidosis ": 7.003727962019444, "Acute kidney injury ": 6.228787249005719, "Adrenal insufficiency ": 10.272192357951718, "Allergic sinusitis ": 182.72392452058568, "Ankylosing spondylitis ": 5.361573722202103, "Antinuclear antibody positive ": 20.817546563769028, "Arrhythmia ": 2.9462299577937614, "Arterial haemorrhage ": 41.14437771362002, "Atrial fibrillation ": 2.9328710162173706, "Balanitis candida ": 218.7026727542693, "Balanoposthitis ": 46.544787654675865, "Blood creatinine increased ": 2.3925308951798296, "Blood glucose abnormal ": 4.100697428310465, "Blood glucose fluctuation ": 3.053651763666667, "Blood iron decreased ": 10.72022974252701, "Blood lactic acid increased ": 9.599695114040616, "Blood potassium increased ": 6.998479867072879, "Blood uric acid increased ": 8.696923788584629, "Bradycardia ": 2.494857303150518, "Candida infection ": 25.41204143331916, "Cardiac failure chronic ": 9.437037854556277, "Cyst ": 11.757929021535752, "Cystitis ": 7.275308835706903, "Dehydration ": 6.025391287107175, "Diabetes mellitus inadequate control ": 3.97884509518968, "Diabetic foot ": 33.98247064535207, "Diabetic ketoacidosis ": 89.44592024531175, "Diabetic ketosis ": 52.805590231642086, "Diabetic neuropathy ": 8.688665250009107, "Dry skin ": 2.0056512877454336, "Dysuria ": 4.041370388861208, "Eosinophilic myocarditis ": 54.64717491053017, "Euglycaemic diabetic ketoacidosis ": 379.8467784748874, "Fournier's gangrene ": 113.05436512855135, "Gastroenteritis ": 3.326236460959717, "Glomerular filtration rate decreased ": 11.458758221066695, "Glycosylated haemoglobin increased ": 7.112116025254086, "Haematocrit increased ": 65.15206964147711, "Haemoglobin increased ": 50.79588195266864, "Hyperglycaemia ": 2.95399909357365, "Hyperkalaemia ": 4.006720734983727, "Hyperlipidaemia ": 3.780612691865135, "Hyperthyroidism ": 6.120619846197168, "Hypoglycaemia ": 4.397203672589612, "Hypophagia ": 3.110412544317012, "Hypotension ": 4.140631330297168, "Hypovolaemia ": 68.58981438559384, "Iron deficiency ": 10.507505644919796, "Joint effusion ": 9.595378390794128, "Ketoacidosis ": 63.66953893745229, "Ketonuria ": 32.904785171522995, "Ketosis ": 35.91606200639334, "Lactic acidosis ": 10.105999062525663, "Left atrial dilatation ": 159.2949034589921, "Medication error ": 3.2566071668004475, "Mental status changes ": 2.4093129759983527, "Metabolic acidosis ": 21.154526142699968, "Mitral valve incompetence ": 4.298817735758627, "Mucosal dryness ": 51.46793241103668, "Necrotising fasciitis ": 26.727844286177287, "Nephrolithiasis ": 2.218609141326887, "Oedema peripheral ": 2.71841044955868, "Osteoarthritis ": 2.3215074124233177, "Pancreatitis acute ": 3.746006424900579, "Pemphigoid ": 4.204358201331185, "Peripheral ischaemia ": 22.54036167742105, "Pollakiuria ": 12.240661494588526, "Polycythaemia ": 25.16137389725629, "Polydipsia ": 9.441444816522113, "Polyuria ": 21.63219746544057, "Presyncope ": 4.06641024417524, "Product monitoring error ": 67.54661012311233, "Product prescribing error ": 3.152934165131456, "Pruritus genital ": 25.75357746727545, "Pulmonary congestion ": 8.528371870009366, "Pyelonephritis ": 8.135602444809566, "Renal disorder ": 5.326138401352498, "Renal impairment ": 2.018041901405577, "Sepsis ": 2.4272270669587845, "Septic shock ": 2.0493199679513547, "Skin disorder ": 5.47350059612092, "Skin ulcer ": 4.484422136846033, "Synovial disorder ": 192.74945276491692, "Synovitis ": 2.824049319653149, "Tendonitis ": 3.5214035165709885, "Thirst ": 13.086715335484769, "Toe amputation ": 26.86507434808359, "Treatment noncompliance ": 2.065064144646137, "Troponin increased ": 18.5630518246315, "Type 2 diabetes mellitus ": 2.287267907190837, "Urinary hesitation ": 21.18056836897433, "Urinary tract infection ": 8.772579285498262, "Urosepsis ": 24.96609213199823, "Ventricular extrasystoles ": 4.039213431661975, "Vitamin B12 decreased ": 42.3645271281246, "Vulvovaginal candidiasis ": 81.26775543369882, "Vulvovaginal discomfort ": 29.0323505464779, "Vulvovaginal pruritus ": 38.23713240228954, "Vulvovaginitis ": 60.44133240945552, "Weight decreased ": 2.4188168141176245, "Weight fluctuation ": 13.872612103885716} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/396.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/396.json new file mode 100644 index 00000000000..ab12b30d4fc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/396.json @@ -0,0 +1 @@ +{"Malignant neoplasm progression ": 10.47792816281476, "Neutropenia ": 6.181810440331533, "Plasma cell myeloma ": 115.28354830433628} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/397.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/397.json new file mode 100644 index 00000000000..f15c66f0499 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/397.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 2.942096135529341, "Acute HIV infection ": 193.12131468787092, "Acute kidney injury ": 3.395105202732249, "Adrenal insufficiency ": 3.258032587139684, "Adverse event ": 3.150107791354043, "Alanine aminotransferase increased ": 3.582000136693249, "Ascites ": 2.9907718284534512, "Aspartate aminotransferase increased ": 2.5333785524531174, "Ataxia ": 2.82274568064511, "Atrial septal defect ": 20.260540210180885, "Blood HIV RNA increased ": 77.30947989876877, "Blood alkaline phosphatase increased ": 4.357577160408731, "Blood bilirubin increased ": 2.901572515512855, "Blood creatinine increased ": 2.549051849328, "Blood triglycerides increased ": 5.250018360232792, "Bone disorder ": 4.120061661074426, "CD4 lymphocytes decreased ": 24.19391661546745, "CSF HIV escape syndrome ": 299.2731372212314, "Cerebellar syndrome ": 23.98158578382504, "Cholestasis ": 2.709380811195733, "Congenital anomaly ": 6.176010083784889, "Creatinine renal clearance decreased ": 10.426168998461415, "Developmental delay ": 6.821779447928377, "Dilated cardiomyopathy ": 8.613779352798565, "Drug interaction ": 4.53382146344313, "Drug reaction with eosinophilia and systemic symptoms ": 4.322383048592998, "Drug resistance ": 28.68399807816939, "Encephalitis ": 4.593915265610619, "Enlarged clitoris ": 294.15624518269175, "Exposure during pregnancy ": 5.70048580593172, "Fanconi syndrome ": 23.25402452609354, "Fanconi syndrome acquired ": 22.815972031634843, "Foetal exposure during pregnancy ": 12.020781934089824, "Folliculitis ": 2.116534192884324, "Genotype drug resistance test positive ": 69.99170557169604, "Glomerular filtration rate decreased ": 11.217394176131512, "Glycosuria ": 38.58930676135778, "HIV infection ": 46.538992949554846, "HIV test positive ": 108.94046551656396, "HIV-associated neurocognitive disorder ": 148.60740218812705, "Haemorrhagic diathesis ": 14.743719408191971, "Hepatic function abnormal ": 2.8756629219362466, "Hepatitis B ": 20.994179313240178, "Hepatomegaly ": 4.723320937088181, "Hepatotoxicity ": 7.129990647187765, "Hyperandrogenism ": 593.189358975067, "Hyperbilirubinaemia ": 8.678625914807302, "Hypertriglyceridaemia ": 8.325414961562897, "Hypophosphataemia ": 18.33753547871697, "Immune reconstitution inflammatory syndrome ": 156.74902480651065, "Immune reconstitution inflammatory syndrome associated Kaposi's sarcoma ": 274.1748553756677, "Immune reconstitution inflammatory syndrome associated tuberculosis ": 200.26380668698064, "Kaposi's sarcoma ": 25.14681877757972, "Lactic acidosis ": 4.4671318464322045, "Lipodystrophy acquired ": 17.559610123437768, "Live birth ": 5.471324079702918, "Low birth weight baby ": 8.66007261104367, "Maternal exposure during pregnancy ": 8.152203166310473, "Meningitis cryptococcal ": 57.65008032027289, "Metabolic acidosis ": 5.552220482419975, "Multiple organ dysfunction syndrome ": 2.134475171057049, "Nephropathy toxic ": 50.58966648649003, "Neuropsychological symptoms ": 103.25528014840788, "No adverse event ": 11.87495387159626, "Osteopenia ": 4.308766513322853, "Osteoporosis ": 2.154773322619436, "Pancreatitis acute ": 3.033080190170774, "Pancytopenia ": 2.0240553773343986, "Pathogen resistance ": 43.67132036894899, "Pericardial cyst ": 1588.5393538138464, "Pericardial effusion ": 4.316504174223839, "Peritonitis ": 4.682494025458942, "Pneumocystis jirovecii pneumonia ": 8.01648309077969, "Portal hypertension ": 19.21823019636772, "Premature baby ": 6.460503986240286, "Premature delivery ": 10.735411485505155, "Proteinuria ": 6.503786909132362, "Renal disorder ": 2.907114031179442, "Renal impairment ": 5.387850275683502, "Renal tubular acidosis ": 28.0202350520218, "Renal tubular disorder ": 12.369877000471435, "Renal tubular dysfunction ": 57.13217686600649, "Renal tubular necrosis ": 10.414453272042175, "Treatment failure ": 5.116650058523083, "Treatment noncompliance ": 11.136391395592392, "Tuberculosis ": 10.76878032218702, "Varices oesophageal ": 22.74528012338434, "Ventricular septal defect ": 30.86111790984014, "Viral load increased ": 18.884105716020542, "Viral mutation identified ": 48.289062039213576, "Virologic failure ": 55.0722778670858, "Weight increased ": 2.0329107554446235} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/398.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/398.json new file mode 100644 index 00000000000..8bfd2f929d1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/398.json @@ -0,0 +1 @@ +{"Diarrhoea ": 2.3874353152932573, "Product substitution issue ": 79.69252866459298} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/399.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/399.json new file mode 100644 index 00000000000..4645a1afd45 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/399.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.7034248483745524, "Acute kidney injury ": 5.4124060858477, "Aplasia pure red cell ": 18.74988426690793, "Autonomic neuropathy ": 194.14946612919385, "Blood bilirubin increased ": 12.182984772246114, "Blood creatine phosphokinase increased ": 3.789295374980386, "Blood creatinine increased ": 6.0784234169184375, "Blood phosphorus decreased ": 73.82414740774543, "Caesarean section ": 26.86289957186088, "Drug resistance ": 19.236133938849942, "Dysarthria ": 3.73013279505712, "Fanconi syndrome acquired ": 41.46213260682574, "Foetal exposure during pregnancy ": 3.993836754884389, "Genotype drug resistance test positive ": 232.04572794552456, "Hepatic cytolysis ": 4.842451934203848, "Hepatic enzyme increased ": 3.491546694019553, "Hypercholesterolaemia ": 24.183076725052317, "Hyperkalaemia ": 3.2492427253827123, "Hypertriglyceridaemia ": 19.27069761347895, "Ileus ": 27.70636651902821, "Immune reconstitution inflammatory syndrome ": 297.824846055731, "Lactic acidosis ": 4.626745267934338, "Liver function test abnormal ": 5.552062979442419, "Maternal exposure during pregnancy ": 4.4599457388284085, "Nephrolithiasis ": 5.844605947168194, "Neuropathy peripheral ": 3.7250897783491146, "Neurotoxicity ": 24.573582278336744, "Osteonecrosis ": 2.189586290976137, "Photosensitivity reaction ": 15.25648437215026, "Portal hypertension ": 54.101806259511264, "Potentiating drug interaction ": 73.46934545318256, "Rash maculo-papular ": 4.957008854912117, "Renal failure ": 3.451983575293134, "Virologic failure ": 45.5129816677031} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/4.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/4.json new file mode 100644 index 00000000000..f4954cc89ab --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/4.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 6.662661300633792, "Abdominal pain upper ": 3.767436368640949, "Adjustment disorder with depressed mood ": 61.32956318748553, "Adverse drug reaction ": 2.3489341104905144, "Alanine aminotransferase abnormal ": 14.165756972667689, "Alopecia ": 6.1739925216996125, "Amnesia ": 5.919864396869161, "Anal abscess ": 3.5072282205427, "Anti-cyclic citrullinated peptide antibody ": 64.26207967972435, "Anti-cyclic citrullinated peptide antibody positive ": 28.10478528654915, "Antibody test positive ": 6.024795455616933, "Arthritis ": 5.744678399975245, "Arthropathy ": 14.998149458397153, "Asthma ": 2.47057454260862, "Autoimmune disorder ": 23.456468274596308, "Back injury ": 25.370515987528453, "Basal cell carcinoma ": 5.950654589065102, "Blepharospasm ": 22.653366617450757, "Blister ": 13.394261660132887, "Blood cholesterol ": 12.165598739048407, "Blood cholesterol increased ": 15.955775943618322, "Blood magnesium increased ": 15.28101222462559, "Blood parathyroid hormone decreased ": 21.417666916848027, "Body height below normal ": 23.44327185612402, "Body temperature ": 2.2542450274397665, "Bone density increased ": 20.21140819726369, "Bone erosion ": 57.41947948371461, "Breast cancer stage I ": 22.914189167139487, "Breast cancer stage II ": 39.72721745231772, "Breast cancer stage III ": 88.56662650220915, "Bunion operation ": 16.794693512512385, "Bursitis ": 30.32749427483968, "C-reactive protein ": 17.56995773061908, "C-reactive protein abnormal ": 29.590680782105757, "C-reactive protein increased ": 10.926748426316138, "Colitis ulcerative ": 3.728922828078847, "Condition aggravated ": 2.791753330346998, "Confusional state ": 4.399914261458783, "Contraindicated product administered ": 17.164194004458192, "Contusion ": 5.2053575294082295, "Crohn's disease ": 2.701329679556612, "Cyst ": 2.965356649095945, "Deafness neurosensory ": 3.366378395477557, "Deep vein thrombosis postoperative ": 35.64437564301909, "Deformity ": 8.234308422778563, "Delirium ": 3.728052715681324, "Depression ": 2.2616518827066425, "Disability ": 11.797666383255653, "Discomfort ": 5.391043992362601, "Dislocation of vertebra ": 56.30628458589917, "Drug hypersensitivity ": 6.375439571464654, "Drug ineffective ": 2.138160620783381, "Drug intolerance ": 7.470687869213298, "Drug specific antibody ": 3.0548685235044983, "Drug tolerance ": 5.714828708205755, "Drug tolerance decreased ": 10.428915828017496, "Drug-induced liver injury ": 2.112925007653574, "Dry mouth ": 4.109238286875727, "Duodenal ulcer perforation ": 28.070132257286875, "Ear infection ": 4.468821374598521, "Ear pain ": 5.723888975939825, "Enthesopathy ": 18.75733777735539, "Epigastric discomfort ": 4.412475309196731, "Epilepsy ": 4.1249858735047225, "Epstein-Barr viraemia ": 4.78309512281517, "Exostosis ": 20.170083708797023, "Facet joint syndrome ": 51.00714681532218, "Fear of injection ": 12.054149175888003, "Fibromyalgia ": 13.873957033250612, "Finger deformity ": 4.600584458865994, "Folliculitis ": 37.460205707026105, "Foot deformity ": 11.857098787093443, "Foot operation ": 6.443164225527807, "Gait inability ": 5.8667863394743, "Gastrointestinal disorder ": 6.275994403508665, "Gastrointestinal toxicity ": 2.9885736471643223, "Gastrooesophageal reflux disease ": 4.377232313250558, "General physical health deterioration ": 4.2219580720072685, "Glossodynia ": 12.550991274823414, "Granuloma ": 2.030698364835504, "Granuloma skin ": 15.88039528634048, "Grip strength decreased ": 7.826887145723598, "Hand deformity ": 15.581628363004784, "Helicobacter infection ": 18.727975104458583, "Hepatic enzyme increased ": 5.273447907018985, "Hip arthroplasty ": 9.4061206372515, "Human antichimeric antibody positive ": 31.064447951053896, "Hypercalcaemia ": 3.2440785709175644, "Hypercholesterolaemia ": 21.11295101876185, "Hypersensitivity ": 3.341995080375345, "Ill-defined disorder ": 11.724179488087708, "Impaired healing ": 26.35880766796328, "Infection ": 5.802664379808832, "Inflammation ": 6.304272084763363, "Inflammatory marker increased ": 3.102967102413823, "Infusion related reaction ": 8.092317732085135, "Infusion site reaction ": 142.6571936681913, "Injury ": 5.999450956616284, "Intentional product use issue ": 6.020497934137922, "Irritable bowel syndrome ": 28.4834974701842, "Joint destruction ": 23.21624083253435, "Joint dislocation ": 5.583260710639072, "Joint effusion ": 4.447180908591867, "Joint injury ": 2.647338466343225, "Joint range of motion decreased ": 16.99471452308404, "Joint stiffness ": 3.577990529636573, "Joint swelling ": 10.146508111296583, "Juvenile idiopathic arthritis ": 12.696302798484156, "Keratitis ": 3.641507070727722, "Knee arthroplasty ": 9.61221184378673, "Lip dry ": 35.09686344749346, "Live birth ": 20.489959678244837, "Liver function test increased ": 7.513354477643465, "Liver injury ": 6.237150576884588, "Lower respiratory tract infection ": 17.774333238911268, "Lung disorder ": 3.866684554856171, "Lupus vulgaris ": 7.41983028310854, "Lupus-like syndrome ": 2.531384307836116, "Maternal exposure during pregnancy ": 4.02870271799851, "Mean cell haemoglobin decreased ": 12.679799079149811, "Mean cell volume decreased ": 15.183263770956415, "Mean platelet volume decreased ": 33.45090619095597, "Medication error ": 2.57033741951046, "Mobility decreased ": 4.913332455544526, "Monocyte count increased ": 6.667587432343806, "Muscle injury ": 55.36681997060485, "Muscle spasticity ": 14.691566236391054, "Musculoskeletal deformity ": 94.34284544781342, "Musculoskeletal pain ": 8.044003778959254, "Musculoskeletal stiffness ": 2.4516636390671667, "Nail disorder ": 32.04519269060555, "Nasopharyngitis ": 5.978449769229223, "Night sweats ": 7.689297613991, "Obesity ": 11.236654246463274, "Onychomadesis ": 29.414550483968867, "Osteoarthritis ": 6.140323854067137, "Panniculitis ": 7.340176358882203, "Pemphigus ": 10.652675469681675, "Pericarditis ": 3.0618943151788667, "Peripheral swelling ": 4.307888223523494, "Peripheral venous disease ": 6.9820024103254, "Physical disability ": 2.921572667942407, "Pleural fibrosis ": 22.850581039941893, "Pleural thickening ": 11.486349846877108, "Presbyacusis ": 33.73003723200497, "Prescribed underdose ": 2.223185444810729, "Product use issue ": 2.535007626375071, "Psoriatic arthropathy ": 3.3826314681527347, "Pulmonary fibrosis ": 2.4159939921091484, "Red blood cell sedimentation rate ": 30.053492596664142, "Red blood cell sedimentation rate abnormal ": 11.234574149417629, "Red blood cell sedimentation rate increased ": 5.46967153602994, "Red cell distribution width decreased ": 69.3982950456062, "Red cell distribution width increased ": 2.5076774300706712, "Respiratory disorder ": 5.856262404865904, "Respiratory tract congestion ": 2.875009572772489, "Retinitis ": 7.384913383470053, "Rheumatic fever ": 13.66114112684857, "Rheumatoid arthritis ": 6.104104497081946, "Rheumatoid factor positive ": 13.04151135261995, "Rheumatoid lung ": 15.62240243767165, "Rheumatoid nodule ": 12.432784570423705, "Sciatica ": 2.982553719062857, "Seronegative arthritis ": 7.116980147053906, "Sinusitis ": 12.640464995476274, "Sleep disorder due to general medical condition, insomnia type ": 55.90672885845112, "Spinal fusion surgery ": 4.4837285779646905, "Spondylitis ": 3.818274494303122, "Stomatitis ": 6.810092634839062, "Swelling ": 4.964920347885803, "Swollen joint count increased ": 19.69115961061168, "Synovitis ": 10.257744862955487, "Systemic lupus erythematosus ": 6.677206798693604, "Systemic lupus erythematosus rash ": 8.6466802816011, "Tenosynovitis ": 2.9935436534030835, "Therapeutic product effect decreased ": 13.289828842623251, "Treatment failure ": 4.0626569741839, "Type 2 diabetes mellitus ": 2.1298724282569634, "Vascular access complication ": 18.852504922564123, "Viral upper respiratory tract infection ": 3.745452782178869, "Walking aid user ": 6.152885800556383, "Weight increased ": 3.222054334476333, "White blood cell count abnormal ": 5.242781843671874, "Wound ": 6.754910648109536, "Wound infection ": 8.122044523976754, "Wrist deformity ": 15.495063966225494, "X-ray abnormal ": 10.694081544966172} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/40.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/40.json new file mode 100644 index 00000000000..fb3450b4f64 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/40.json @@ -0,0 +1 @@ +{"Abdominal distension ": 3.292372458892356, "Abdominal pain upper ": 2.793266605371511, "Accidental exposure to product ": 16.437353676171643, "Adverse reaction ": 3.8754338835926543, "Alopecia ": 5.462579180612203, "Anti-cyclic citrullinated peptide antibody positive ": 2.0815128760090427, "Antinuclear antibody positive ": 3.1776023626917387, "Anuria ": 14.203559456009351, "Aphasia ": 2.924425608295886, "Arteriospasm coronary ": 5.793762369576544, "Aura ": 23.18856569337211, "Autoimmune thyroiditis ": 2.4242388451671504, "Back injury ": 7.091021193884172, "Blepharospasm ": 42.20960970134791, "Blood pressure measurement ": 9.192329819907563, "Bowel movement irregularity ": 3.243493863060225, "Brain fog ": 3.2686543840351256, "Brain injury ": 2.140162884801881, "Breast cancer stage III ": 7.79228822361316, "Bursitis ": 3.1401533866807663, "C-reactive protein abnormal ": 3.5459097328053164, "Cerebellar infarction ": 3.17833712947992, "Cerebrospinal fluid leakage ": 4.103051420283254, "Cervicogenic headache ": 71.70637535375774, "Cluster headache ": 4.140378339110549, "Coeliac disease ": 4.915619082930372, "Colitis ischaemic ": 3.1065727595164567, "Colour blindness ": 9.897907229596813, "Communication disorder ": 9.292344786464842, "Concussion ": 22.57161702308696, "Constipation ": 15.590454420594584, "Contraindicated product administered ": 2.795384371498977, "Coronavirus infection ": 3.7059863908644046, "Craniocerebral injury ": 5.950020998808764, "Depression suicidal ": 2.5191300588259784, "Device defective ": 8.770505469473079, "Device delivery system issue ": 4.530822690466712, "Device difficult to use ": 207.13185037430225, "Device issue ": 15.21966480342774, "Device leakage ": 5.256466733102113, "Device malfunction ": 4.727205347343143, "Device use error ": 11.108017685912287, "Device use issue ": 2.616855563620365, "Discomfort ": 2.3319618163685942, "Disturbance in attention ": 2.743612918391288, "Drug dose omission by device ": 77.35683228485748, "Drug effect less than expected ": 3.669005170764745, "Drug ineffective ": 2.314777476444408, "Drug ineffective for unapproved indication ": 11.236269723556031, "Drug intolerance ": 7.435817250022382, "Dyschezia ": 7.027550279297166, "Dyspepsia ": 4.382903780844188, "Epilepsy ": 6.548548839867366, "Extrapyramidal disorder ": 9.769733496966031, "Faecaloma ": 6.849467924341745, "Faeces hard ": 9.385272073359168, "Fear of injection ": 6.181806712829599, "Fixed eruption ": 3.780103456668012, "Flatulence ": 2.209211075706495, "Flushing ": 2.240911460250971, "Galactorrhoea ": 3.7777804707738607, "Gastrointestinal infection ": 2.0943316134140035, "Gastrointestinal motility disorder ": 7.850400456265434, "Gastrointestinal obstruction ": 5.593811570637025, "Gastrointestinal sounds abnormal ": 2.1280137911869565, "Gastrooesophageal reflux disease ": 7.421474488177809, "Gingival disorder ": 2.522263517015274, "Heart rate abnormal ": 2.8712571655277626, "Hostility ": 32.03911444907603, "Hyperaesthesia teeth ": 5.924811631390887, "Hypoaesthesia ": 2.8584624201666777, "Ileus ": 2.2143310170188677, "Ileus paralytic ": 2.6753985625393493, "Impaired gastric emptying ": 6.574601778911032, "Incorrect disposal of product ": 129.5628809387308, "Incorrect dose administered ": 2.809875304302876, "Incorrect dose administered by device ": 11.13212766531186, "Incorrect route of product administration ": 6.444768777197345, "Initial insomnia ": 2.2405672739137503, "Injection site bruising ": 4.126477337170444, "Injection site extravasation ": 9.79943382609506, "Injection site haemorrhage ": 10.126202711468084, "Injection site hypersensitivity ": 4.933994065692652, "Injection site indentation ": 39.54495787148606, "Injection site irritation ": 7.575003261939572, "Injection site pruritus ": 2.231691375073261, "Injection site rash ": 6.683290972784993, "Injection site urticaria ": 9.125992622190436, "Injection site vesicles ": 3.04523206805003, "Injury associated with device ": 2.901570474306605, "Intercepted product administration error ": 24.72587207117854, "Intestinal obstruction ": 4.314971690625816, "Irritable bowel syndrome ": 2.018269559401185, "Jaw disorder ": 4.727877554123955, "Libido increased ": 30.87106876122801, "Loose tooth ": 3.594372556266701, "Lymphatic malformation ": 46.122476759013765, "Macular dystrophy congenital ": 531.1042025712393, "Mastoiditis ": 153.45786364683454, "May-Thurner syndrome ": 91.6856170724836, "Medication overuse headache ": 57.030724371770056, "Memory impairment ": 6.244432116238149, "Menopausal symptoms ": 3.506349710630265, "Menopause ": 3.4660200546216697, "Middle insomnia ": 7.415357607661773, "Migraine ": 28.98863992328096, "Migraine with aura ": 10.56067372608402, "Migraine without aura ": 15.321054923766384, "Muscle spasms ": 2.9961601927085346, "Muscle tightness ": 2.227416524332326, "Muscle twitching ": 3.850955047190574, "Neck pain ": 2.473767578477926, "Needle issue ": 8.790527182282677, "Neovascularisation ": 448.1284763804093, "Nephrolithiasis ": 2.401879705200065, "Neurofibrosarcoma ": 55.87139936988857, "Night blindness ": 12.001838663294162, "Nightmare ": 3.228535423380225, "Normal newborn ": 4.303093242707801, "Onychoclasis ": 2.475155971563972, "Otitis media ": 23.196685106510127, "Ovarian cyst ": 3.138392394705308, "Panic attack ": 2.133936587057049, "Panic disorder ": 2.3617556178445547, "Paradoxical drug reaction ": 52.13227418084397, "Paraesthesia ": 2.331078459727568, "Paranasal cyst ": 568.2280886626462, "Personality disorder ": 21.65268290935972, "Photophobia ": 2.33155031839947, "Polyp ": 2.186691439366262, "Poor dental condition ": 17.99253239661731, "Poor quality sleep ": 6.2234132316662025, "Post-traumatic neck syndrome ": 128.7630895554759, "Post-traumatic stress disorder ": 2.721819665250952, "Product administered at inappropriate site ": 2.807321070644702, "Product administration interrupted ": 7.403961965885593, "Product communication issue ": 23.80309226130351, "Product storage error ": 6.538863636427508, "Product supply issue ": 2.331346588133291, "Product use in unapproved indication ": 3.0424462463688844, "Quality of life decreased ": 2.3884039981149265, "Raynaud's phenomenon ": 10.593773639948637, "Rebound effect ": 3.0889517882026007, "Red cell distribution width increased ": 2.4283902425707447, "Reversible cerebral vasoconstriction syndrome ": 5.032540246222401, "Rib fracture ": 4.934335273085088, "Rubber sensitivity ": 57.283429019661945, "Sedation ": 3.2701500683888534, "Skin cancer ": 2.3605921477931244, "Skin swelling ": 2.013434367424705, "Sleep disorder ": 2.193179179637418, "Small intestinal obstruction ": 2.363202196734796, "Snoring ": 2.2724801373612182, "Soft tissue injury ": 115.21539016610366, "Status migrainosus ": 61.67360571409265, "Sternal fracture ": 82.93110268535288, "Stress ": 7.349167480154613, "Syringe issue ": 7.012782889014786, "Taste disorder ": 8.82955943938664, "Tension headache ": 5.216569843638351, "Therapeutic product effect decreased ": 4.364717978775044, "Therapeutic product effect delayed ": 2.6244849548115163, "Therapeutic product effect incomplete ": 2.9726681898622136, "Therapeutic response decreased ": 3.885866496724712, "Therapeutic response shortened ": 20.63305862345607, "Therapy partial responder ": 9.812814041886568, "Tinnitus ": 2.242797215287148, "Treatment failure ": 2.3678015546102187, "Trigeminal neuralgia ": 2.8302517731531687, "Vascular malformation ": 255.05513456673583, "Vestibular disorder ": 6.498008729751371, "Vestibular migraine ": 14.547280768195286, "Visual field defect ": 3.68479689295694, "Volvulus ": 7.2024479200543645, "Weight increased ": 3.2878357991115723, "Wrong technique in device usage process ": 3.506081451669452, "Wrong technique in product usage process ": 7.93347978391759} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/400.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/400.json new file mode 100644 index 00000000000..1a8bc712e3a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/400.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.581765815120143, "Adverse event ": 8.35749858790516, "Angioedema ": 7.385229777316709, "Asthenia ": 7.7767120719421134, "Atrial enlargement ": 775.9646085531555, "Blood pressure decreased ": 4.593591274828652, "Cardiac failure ": 6.397124660390862, "Dehydration ": 6.559043068384429, "Disease progression ": 3.262781432038645, "Gait disturbance ": 4.454981946324356, "Hyperkalaemia ": 6.505488191029216, "Hypotension ": 4.9821225238333176, "Hypovolaemia ": 71.48626663745546, "N-terminal prohormone brain natriuretic peptide increased ": 148.79490798639085, "Overdose ": 2.644313198169167, "Pulmonary arterial pressure increased ": 244.09730022711895, "Tricuspid valve incompetence ": 58.410053902137946, "Urinary tract infection ": 5.65841191026963} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/401.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/401.json new file mode 100644 index 00000000000..9ec8a41db7a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/401.json @@ -0,0 +1 @@ +{"Abscess ": 2.148186430149844, "Adverse drug reaction ": 5.681285175493105, "Alanine aminotransferase increased ": 3.316099199981201, "Allergic oedema ": 6.802785023101931, "Alopecia ": 2.65383380768433, "Amyotrophic lateral sclerosis ": 3.6315243472946697, "Ankylosing spondylitis ": 7.850933516294374, "Anticipatory anxiety ": 250.2132357798923, "Antinuclear antibody positive ": 2.532852673095394, "Apparent death ": 6.305589108307958, "Appendix disorder ": 8.868550832362711, "Arteriospasm coronary ": 2.431936267398563, "Arthritis ": 3.985767813405747, "Arthritis bacterial ": 3.0387715170336347, "Arthritis infective ": 3.891164551228452, "Arthrodesis ": 14.831745069338524, "Arthropathy ": 7.210858829302754, "Arthropod bite ": 3.0598672708087853, "Aspartate aminotransferase increased ": 3.598534707494162, "Basal cell carcinoma ": 19.814006380777894, "Bipolar disorder ": 5.963753788941821, "Blood creatinine decreased ": 3.705325774906325, "Blood magnesium increased ": 8.471494290177265, "Blood parathyroid hormone decreased ": 74.07229167258488, "Bone cyst ": 9.510019296380248, "Bone erosion ": 12.31566512792174, "Bone hypertrophy ": 28.954620418650947, "Breast abscess ": 9.447609357133034, "Bronchitis chronic ": 14.59417765144482, "Bursitis ": 2.164206841024705, "Butterfly rash ": 5.1917373130449205, "C-reactive protein abnormal ": 21.535569730360656, "C-reactive protein decreased ": 33.268955885801326, "C-reactive protein increased ": 5.6046289040971216, "Carpal tunnel syndrome ": 7.316151262467264, "Cartilage injury ": 5.083033701045409, "Coeliac disease ": 3.1492798545245924, "Condition aggravated ": 3.388936142415284, "Contraindicated product administered ": 13.452831282530967, "Contrast media allergy ": 46.46160808954346, "Crohn's disease ": 2.5538235771452324, "Cyst ": 2.812616257494577, "Dactylitis ": 26.875964891006127, "Deafness neurosensory ": 2.1154314104426546, "Deformity ": 3.6368264206230574, "Demyelination ": 2.676618414305116, "Dental caries ": 2.9782234198593858, "Dermatitis allergic ": 4.674872070874673, "Disability ": 2.649641844161177, "Diverticulitis ": 3.057086490494179, "Drug eruption ": 5.334107404167554, "Drug hypersensitivity ": 10.07482545455558, "Drug ineffective ": 5.9737105508558175, "Drug intolerance ": 12.402724176089857, "Drug tolerance ": 3.602282378117938, "Drug tolerance decreased ": 16.58228362061501, "Drug use disorder ": 28.38479183045444, "Dry eye ": 3.4568066204841483, "Elbow deformity ": 55.28532005285244, "Enthesopathy ": 10.666175334870616, "Epicondylitis ": 3.700376135537051, "Epigastric discomfort ": 2.0186486671499395, "Episcleritis ": 11.998422687703528, "Exostosis ": 2.9834508503562867, "Eye disorder ": 2.873255550392474, "Eye operation ": 5.346340697528044, "Fat necrosis ": 22.02210697040369, "Fear of injection ": 11.73309678014015, "Femur fracture ": 5.1506064497910975, "Fibromyalgia ": 5.443243808640176, "Fine motor skill dysfunction ": 4.373285539671607, "Finger deformity ": 14.096454907523595, "Foetal death ": 2.76127324470853, "Food allergy ": 6.081150035495683, "Foot deformity ": 8.985730703069285, "Frustration tolerance decreased ": 4.007564142364574, "Gait inability ": 3.1174733891132624, "Gastrointestinal disorder ": 2.0760346095851965, "Gastrointestinal inflammation ": 3.056925040868808, "Gastrointestinal toxicity ": 17.718969571538267, "Goitre ": 2.9666740776207483, "Granuloma skin ": 73.18989470067538, "Grip strength decreased ": 3.462629443539892, "HLA marker study positive ": 123.61483817330104, "Hepatic enzyme abnormal ": 3.4964052039680613, "Hepatic enzyme increased ": 3.25898124994273, "Hepatic fibrosis ": 10.122942352231377, "Hepatotoxicity ": 4.832846870144331, "Herpes ophthalmic ": 3.065783985862817, "Hip arthroplasty ": 2.256174423315356, "Hip surgery ": 2.418730405285088, "Hypercalcaemia ": 14.266525093350074, "Hypercholesterolaemia ": 3.911389547997099, "Hypersensitivity ": 2.086711100693696, "Hypersensitivity vasculitis ": 13.945891487517772, "Immobile ": 4.829618637233338, "Immune system disorder ": 3.026578798794174, "Immunodeficiency ": 8.689095809016184, "Immunosuppression ": 2.3579055559047446, "Impaired healing ": 2.7830309969157194, "Impaired work ability ": 3.861505527848524, "Increased tendency to bruise ": 2.703611448780231, "Infection ": 3.261610439706248, "Inflammation ": 7.753574742263338, "Infusion related reaction ": 5.363018848885099, "Infusion site reaction ": 4.003917278550165, "Injection site bruising ": 7.9123858164873395, "Injection site discolouration ": 3.8228625315288856, "Injection site hypersensitivity ": 2.6018255195136555, "Injection site rash ": 3.408703104418113, "Injection site reaction ": 2.529148801741128, "Injection site urticaria ": 3.2057358762172123, "Injection site vesicles ": 2.6492935831254703, "Intervertebral disc disorder ": 12.63241443450103, "Intervertebral disc protrusion ": 3.064529740748831, "Intestinal sepsis ": 26.343019894896837, "Intra-abdominal fluid collection ": 4.916635187926729, "Iritis ": 2.1017291151665374, "Joint arthroplasty ": 4.526261366401162, "Joint destruction ": 10.2415698516852, "Joint effusion ": 3.564680666890032, "Joint injury ": 19.67202122347509, "Joint laxity ": 30.58901823370553, "Joint lock ": 3.242084077554121, "Joint noise ": 3.36417806254582, "Joint range of motion decreased ": 7.721827725946437, "Joint stiffness ": 7.448883067901711, "Joint swelling ": 11.469738339878925, "Joint warmth ": 6.124928793805195, "Juvenile idiopathic arthritis ": 4.09626974103659, "Knee arthroplasty ": 9.178121599585564, "Knee deformity ": 6.484079502840394, "Kyphoscoliosis ": 84.67629880236318, "Laboratory test abnormal ": 2.0135594067108755, "Latent tuberculosis ": 17.5118111608106, "Limb deformity ": 4.49399211616613, "Lipoma ": 2.512218287165735, "Liver disorder ": 4.627624697476847, "Liver function test increased ": 2.021581926342047, "Localised infection ": 3.8850356594788753, "Loss of personal independence in daily activities ": 4.707693381479931, "Lower respiratory tract infection ": 3.8164781746322, "Lupus-like syndrome ": 3.593545189691137, "Lymphoma ": 3.4998076706520127, "Malignant melanoma ": 2.276871814387254, "Mass excision ": 21.894055788917104, "Mean cell volume decreased ": 4.536834626904256, "Melanocytic naevus ": 5.284586953967684, "Mobility decreased ": 4.759365326516916, "Monocyte count increased ": 4.331263327736288, "Multiple system atrophy ": 31.004383141107738, "Multisystem inflammatory syndrome ": 21.133042977406035, "Musculoskeletal deformity ": 25.20263751362485, "Musculoskeletal discomfort ": 5.877989575141969, "Musculoskeletal disorder ": 6.081405235345452, "Musculoskeletal pain ": 7.100525542067282, "Musculoskeletal stiffness ": 6.346298454153795, "Myofascial pain syndrome ": 25.09936470855124, "Nasal discomfort ": 2.612436676619505, "Nasopharyngitis ": 2.0454432109076377, "Neoplasm skin ": 9.489136364530047, "Nephrostomy ": 25.874465543965314, "Nerve block ": 44.275926947221066, "Nodule ": 5.8676192756406085, "Obliterative bronchiolitis ": 22.3294370278092, "Oesophageal ulcer ": 2.264334979348395, "Onychoclasis ": 3.1066982828464145, "Oral surgery ": 13.751976031298096, "Osteoarthritis ": 5.372996052040717, "Osteomyelitis ": 2.274862927741641, "Osteosclerosis ": 8.135285920525464, "Palindromic rheumatism ": 30.61823952005552, "Panniculitis ": 57.87496223132836, "Pathological fracture ": 2.2000042427460413, "Peptic ulcer haemorrhage ": 36.7568383497984, "Peripheral swelling ": 3.373696996181063, "Pharyngeal oedema ": 6.027486491469131, "Pharyngitis ": 3.401486304602118, "Pharyngitis streptococcal ": 2.7230239674428502, "Plantar fasciitis ": 9.453008515832062, "Pleural fibrosis ": 17.93538475976761, "Pneumonia viral ": 6.379295281905739, "Polyarthritis ": 2.6168142628908115, "Post procedural complication ": 3.444012119654817, "Post procedural infection ": 4.211825732761012, "Presbyacusis ": 19.693155027798845, "Pruritus allergic ": 21.743634121495617, "Psoriasis ": 7.020498072099405, "Psoriatic arthropathy ": 4.827931991596277, "Pulmonary fibrosis ": 3.02088802227466, "Pulmonary mass ": 2.178794883435444, "Pulmonary pain ": 4.158137704256864, "Pulmonary toxicity ": 8.985311818759836, "Pustular psoriasis ": 2.0355784959623904, "Pyelonephritis ": 2.120893496059712, "Rash pruritic ": 2.874309927934957, "Red blood cell sedimentation rate abnormal ": 45.7937823890589, "Red blood cell sedimentation rate increased ": 26.98275355078131, "Renal disorder ": 2.129471149492681, "Restless legs syndrome ": 2.0043714520713967, "Retinitis ": 9.651843362267671, "Rheumatoid arthritis ": 24.13359677623724, "Rheumatoid factor negative ": 17.478297757557034, "Rheumatoid factor positive ": 7.463582862760253, "Rheumatoid lung ": 26.565900698901224, "Rheumatoid nodule ": 69.46164349701796, "Rotator cuff syndrome ": 2.221969481743316, "SAPHO syndrome ": 70.36027789015519, "Sacroiliitis ": 12.548333304250576, "Sciatica ": 2.131456938811206, "Seborrhoeic dermatitis ": 3.467001797816167, "Sensitivity to weather change ": 5.347718137703639, "Shoulder arthroplasty ": 12.7797024153782, "Sjogren's syndrome ": 6.021931312365752, "Skin necrosis ": 13.67155809032594, "Skin papilloma ": 3.629311608002093, "Skin ulcer ": 11.157963750771492, "Sleep disorder due to general medical condition, insomnia type ": 2.25174920970401, "Spinal cord infection ": 31.238532098190834, "Spinal osteoarthritis ": 4.797820786853481, "Spinal pain ": 2.1357390169729804, "Spinal stenosis ": 2.6885898959582764, "Still's disease ": 6.96323714412827, "Stress fracture ": 15.262648569195054, "Surgical failure ": 31.32323377043351, "Swelling ": 2.0744617489509505, "Swollen joint count decreased ": 664.4925987928443, "Synovial disorder ": 32.99205075254639, "Synovitis ": 29.59091849214458, "Temperature regulation disorder ": 4.137258353255031, "Tender joint count decreased ": 664.4925987928443, "Tenosynovitis ": 3.6383467405605687, "Terminal state ": 2.54361559263112, "Therapeutic product effect decreased ": 18.353715178035905, "Therapeutic product effect incomplete ": 6.292977619112028, "Therapeutic product ineffective ": 3.237458013278137, "Therapeutic response decreased ": 5.330041749263865, "Therapeutic response shortened ": 3.298332489938167, "Therapy non-responder ": 3.2225515381817025, "Toe amputation ": 2.681468550120289, "Tooth abscess ": 4.109538806857361, "Toothache ": 2.98839315604369, "Treatment failure ": 15.9850860835891, "Trigger finger ": 3.824096978500774, "Tuberculosis ": 2.732461872641268, "Ulcer ": 9.36579048076389, "Upper respiratory tract infection ": 6.038068296926785, "Varicose ulceration ": 22.3068399441898, "Vein disorder ": 6.701074541120087, "Viral infection ": 2.8276648746278634, "Viral upper respiratory tract infection ": 4.552206708749184, "Walking aid user ": 6.17933633199521, "Wheelchair user ": 3.1094182321428505, "Wrist deformity ": 97.71318189320714, "X-ray abnormal ": 8.230361510376955} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/402.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/402.json new file mode 100644 index 00000000000..fe414d1a7d0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/402.json @@ -0,0 +1 @@ +{"Thrombocytopenia ": 34.303632273810564} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/403.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/403.json new file mode 100644 index 00000000000..2e01a18ecf7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/403.json @@ -0,0 +1 @@ +{"Malignant neoplasm progression ": 16.821220033149324} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/404.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/404.json new file mode 100644 index 00000000000..8254e7caa73 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/404.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.04810167906518, "Alanine aminotransferase increased ": 4.843629254406811, "Anxiety ": 2.652666560137375, "Aspartate aminotransferase increased ": 7.772110674524519, "Blood lactic acid increased ": 134.77730553200527, "Death neonatal ": 478.73827759828566, "Depression suicidal ": 188.32462309535268, "Depressive symptom ": 112.08186894398936, "Diplopia ": 28.971876298800037, "Drug interaction ": 2.1382454299435274, "Dysphagia ": 9.334210902213693, "Eyelid ptosis ": 108.78052370969765, "Foetal exposure during pregnancy ": 7.100088648845284, "Haemorrhage ": 5.8560969226171045, "Hepatic steatosis ": 24.90715761283308, "Lipodystrophy acquired ": 155.41778268445293, "Mitochondrial toxicity ": 579.3875928474247, "Ophthalmoplegia ": 288.0299812836236, "Paranoia ": 49.72140767682633, "Product use in unapproved indication ": 4.010150323203283, "Psychiatric decompensation ": 296.7536430572005, "Psychomotor skills impaired ": 135.3868717632304, "Psychotic disorder ": 21.41372563484233, "Small for dates baby ": 210.3907542436804, "Suicidal ideation ": 7.090756800520585, "Tearfulness ": 126.96567792080737} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/405.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/405.json new file mode 100644 index 00000000000..e6bb9db4d16 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/405.json @@ -0,0 +1 @@ +{"Abdominal mass ": 37.57806414249502, "Abdominal pain lower ": 2.5522381308127624, "Abdominal tenderness ": 13.611243752053204, "Abdominal wall haematoma ": 135.36406199380917, "Abdominal wall haemorrhage ": 72.10543517281607, "Abortion ": 7.401587797330903, "Abortion induced ": 2.8466405482711528, "Abortion spontaneous ": 2.136548111081094, "Activated partial thromboplastin time prolonged ": 15.26265350376409, "Acute generalised exanthematous pustulosis ": 2.6247533865860007, "Acute hepatic failure ": 2.580484724187375, "Adrenal haemorrhage ": 77.96876009259375, "Adrenal insufficiency ": 2.244201969131368, "Anaemia ": 2.445166542078693, "Aphasia ": 2.369484532299894, "Arterial haemorrhage ": 38.35073801292001, "Blood loss anaemia ": 6.0924606814262745, "Brain herniation ": 12.238376610482664, "Bullous haemorrhagic dermatosis ": 162.27271490426335, "Caesarean section ": 5.479261196367649, "Cerebral haematoma ": 4.801119144617787, "Cerebral haemorrhage ": 4.569085711423468, "Cerebral palsy ": 25.12070892307524, "Cerebral venous thrombosis ": 10.76097528749592, "Coagulation time prolonged ": 28.40049275492769, "Coagulopathy ": 13.743694546364344, "Compartment syndrome ": 11.12417923374929, "Conjunctival haemorrhage ": 4.901895835345565, "Cyanosis ": 3.4766691810140973, "Deep vein thrombosis ": 5.708584065492969, "Dermatitis bullous ": 9.508658938620826, "Diplegia ": 6.882584813459095, "Drug-induced liver injury ": 3.8929336417149383, "Ecchymosis ": 17.79309940954364, "Embolism ": 7.1293822282274935, "Embolism venous ": 21.32796842663528, "Eosinophilia ": 2.7705884442892934, "Epistaxis ": 2.942008960374096, "Exposure during pregnancy ": 13.161807797548445, "Exposure via breast milk ": 9.158705543895335, "Extradural haematoma ": 44.1142452918582, "Fibrin D dimer increased ": 3.775207167039533, "Flank pain ": 7.2241283802444896, "Foetal death ": 2.357920615241392, "Foetal exposure during pregnancy ": 7.050663440579619, "Foetal growth restriction ": 16.376616214618622, "Foetal heart rate abnormal ": 20.51042388318696, "Gastric haemorrhage ": 3.04311381337581, "Gastrointestinal haemorrhage ": 11.994452504279923, "Gingival bleeding ": 3.9827143682713806, "Haemarthrosis ": 4.93098580283302, "Haematemesis ": 9.689882629833724, "Haematochezia ": 5.168128853245664, "Haematocrit decreased ": 3.240007182005958, "Haematoma ": 13.792405347287277, "Haematoma muscle ": 48.88352752084599, "Haematuria ": 8.627198188519179, "Haemodynamic instability ": 13.966712577101893, "Haemoglobin decreased ": 7.323738547204572, "Haemoperitoneum ": 29.423537489277283, "Haemoptysis ": 9.995659833612605, "Haemorrhage ": 12.352592852079948, "Haemorrhage intracranial ": 11.218470201155275, "Haemorrhage subcutaneous ": 44.10508653729318, "Haemorrhage urinary tract ": 9.713266419414415, "Haemorrhagic stroke ": 6.035949159890146, "Haemothorax ": 8.054653957046709, "Hemiparesis ": 5.047901729147991, "Heparin-induced thrombocytopenia ": 124.1118873726466, "Hepatic enzyme increased ": 2.753829415815492, "Hepatic function abnormal ": 4.58146862287175, "Hepatitis cholestatic ": 2.7480687808331363, "Hepatocellular injury ": 4.3368954949522, "Hyperbilirubinaemia ": 2.4641956367146447, "Hypovolaemic shock ": 22.157071704608715, "Injection site bruising ": 4.311507089019624, "Injection site haematoma ": 3.352210618876561, "Injection site haemorrhage ": 9.029096740130116, "Injection site necrosis ": 14.44022766831718, "Injection site nodule ": 6.432119677991995, "Injection site rash ": 4.27664745271828, "International normalised ratio decreased ": 4.369744797752236, "International normalised ratio increased ": 5.5782886832393945, "Intra-abdominal haematoma ": 46.468432174139, "Intra-abdominal haemorrhage ": 32.631437582704656, "Ischaemic stroke ": 2.041325858046412, "Joint dislocation ": 7.840903504745743, "Labelled drug-drug interaction issue ": 27.204020174561137, "Labelled drug-drug interaction medication error ": 16.890657382638054, "Live birth ": 8.446441254877003, "Liver injury ": 4.526313169693091, "Low birth weight baby ": 17.47392962779129, "Lower gastrointestinal haemorrhage ": 14.002127200170184, "Maternal exposure during pregnancy ": 4.166509741527456, "Melaena ": 10.122748293920669, "Mixed liver injury ": 11.652234839664258, "Mouth haemorrhage ": 4.82537450522635, "Muscle haemorrhage ": 17.850096392352537, "Necrosis ": 4.679541487408792, "Needle issue ": 3.114255613552546, "Nonreassuring foetal heart rate pattern ": 291.07510631178434, "Occult blood positive ": 18.844602033886, "Oliguria ": 4.93564172396745, "Paraplegia ": 6.782309096396426, "Pelvic haematoma ": 83.5619382405621, "Peripheral artery occlusion ": 14.159270387944304, "Petechiae ": 4.77187554756768, "Platelet count decreased ": 6.915977198353559, "Post procedural haemorrhage ": 9.704654856953672, "Posterior reversible encephalopathy syndrome ": 3.1589555388102832, "Pre-eclampsia ": 5.851918563562781, "Premature baby ": 10.370539212061937, "Premature delivery ": 6.692908556746825, "Premature labour ": 6.236331815874247, "Procedural haemorrhage ": 19.80962190286255, "Product prescribing issue ": 5.362835264440401, "Prosthetic cardiac valve thrombosis ": 299.5312729577975, "Prothrombin time prolonged ": 10.550206288224688, "Pulmonary alveolar haemorrhage ": 5.429051976734282, "Pulmonary embolism ": 4.808955317205691, "Pulmonary haemorrhage ": 5.891293067287945, "Purpura ": 4.228419939763872, "Rash maculo-papular ": 3.0293452941722783, "Rectal haemorrhage ": 2.61199365365973, "Respiratory tract haemorrhage ": 26.958344887025344, "Retroperitoneal haematoma ": 108.03102825230611, "Retroperitoneal haemorrhage ": 34.69276445919441, "Sensory loss ": 2.4512796741872647, "Shock ": 2.362132501261065, "Shock haemorrhagic ": 23.631444096834187, "Sinus tachycardia ": 3.452923163483174, "Skin haemorrhage ": 3.4174868880049534, "Skin lesion ": 2.6470272167276545, "Skin necrosis ": 17.228081001423956, "Spinal epidural haematoma ": 23.772728495031576, "Spinal epidural haemorrhage ": 315.80309364596945, "Spontaneous haematoma ": 8.301848461482928, "Subarachnoid haemorrhage ": 3.862276025776406, "Subcutaneous haematoma ": 15.118830384412425, "Subdural haematoma ": 10.969171664236264, "Subdural haemorrhage ": 12.60754683840096, "Tachypnoea ": 3.767979817967928, "Talipes ": 6.548371931157626, "Tenderness ": 2.291590807787024, "Thrombocytopenia ": 4.5849483169663685, "Thrombocytosis ": 7.780007914275118, "Thrombosis ": 3.037490213944926, "Toxic epidermal necrolysis ": 4.01159651663125, "Transaminases increased ": 3.3030469967884937, "Type I hypersensitivity ": 4.01648118204852, "Type IV hypersensitivity reaction ": 11.183205358346154, "Upper gastrointestinal haemorrhage ": 33.35345022945278, "Vaginal haemorrhage ": 2.632437635088713, "Venous thrombosis ": 6.836357549358131} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/406.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/406.json new file mode 100644 index 00000000000..494bbcd05b6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/406.json @@ -0,0 +1 @@ +{"Agitation ": 3.0136677209233658, "Akinesia ": 90.16038367664906, "Balance disorder ": 4.513355337336894, "Behaviour disorder ": 7.937667586832355, "Blood creatine phosphokinase increased ": 4.588567024552758, "Bradykinesia ": 56.495550805304994, "Chromaturia ": 10.166329997854277, "Cognitive disorder ": 5.504113140833774, "Colitis microscopic ": 39.93642886008693, "Compulsive shopping ": 140.37564444815737, "Constipation ": 2.369206381252729, "Delirium ": 2.3457006208151205, "Delusion ": 32.72418609728828, "Dementia ": 5.7229377599229245, "Depressed level of consciousness ": 2.157269882727704, "Dopamine dysregulation syndrome ": 672.2742716305228, "Drug abuse ": 2.378851309861442, "Drug withdrawal syndrome ": 4.927621321142853, "Dyskinesia ": 63.78020925244957, "Dysphagia ": 6.151914750372951, "Dysphonia ": 2.1097123571783083, "Dystonia ": 30.165469395079832, "Eating disorder ": 7.421471110924092, "Fall ": 2.713076180565758, "Gait disturbance ": 5.715473017294619, "Gambling disorder ": 151.69592192483438, "General physical health deterioration ": 2.4877322067064656, "Hallucination ": 8.190409346291263, "Hallucination, visual ": 30.772711995753465, "Hypersexuality ": 165.4767100254095, "Hyperthermia ": 7.379196534772826, "Hypokinesia ": 12.360679957870936, "Hypomania ": 18.694912954293475, "Hyponatraemia ": 3.0186994814974075, "Impulse-control disorder ": 92.71688525003526, "Impulsive behaviour ": 51.4465266678604, "Incorrect dose administered ": 2.009071232631149, "Irritability ": 4.337991242353828, "Loss of personal independence in daily activities ": 2.369763036930724, "Motor dysfunction ": 29.35575909122322, "Movement disorder ": 3.3393979533287625, "Muscle rigidity ": 29.85303263033005, "Musculoskeletal stiffness ": 3.854784034248912, "Mydriasis ": 10.946730025066095, "Neuroleptic malignant syndrome ": 19.767517285193183, "Nightmare ": 3.683581612399953, "On and off phenomenon ": 624.7224564583022, "Oromandibular dystonia ": 258.7186522340258, "Orthostatic hypotension ": 8.658713159599381, "Parkinson's disease ": 89.26674060586625, "Parkinsonian gait ": 195.87889138105592, "Parkinsonism ": 25.524049144938555, "Persecutory delusion ": 28.811704935331065, "Pollakiuria ": 3.1450774877689414, "Psychomotor hyperactivity ": 8.649524864319838, "Quality of life decreased ": 10.613974978487114, "Respiratory failure ": 2.269930607267564, "Resting tremor ": 234.97208418261712, "Restlessness ": 2.3832442306222785, "Rhabdomyolysis ": 3.907979611635122, "Therapeutic response shortened ": 174.86863291804755, "Treatment noncompliance ": 3.288600916973963, "Tremor ": 2.879850505920309, "Urinary incontinence ": 4.874628567359238, "Urinary retention ": 3.306935925816632, "Wrong technique in product usage process ": 2.7074472992354206} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/407.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/407.json new file mode 100644 index 00000000000..a6fccc45f29 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/407.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 3.2826850280997317, "Acute hepatic failure ": 10.783547155231188, "Alanine aminotransferase increased ": 9.492754356043614, "Aspartate aminotransferase increased ": 4.788736362466789, "Blood HIV RNA decreased ": 1119.2050576317483, "Blood bilirubin increased ": 5.079653263444774, "Blood creatine phosphokinase increased ": 5.632796378609466, "Blood creatinine increased ": 7.8563184200077245, "Blood phosphorus decreased ": 78.1716564135315, "Bone pain ": 5.983482777487846, "Creatinine renal clearance decreased ": 20.202244273293964, "Drug ineffective ": 3.7963074871229097, "Drug resistance ": 109.3203281592032, "Fanconi syndrome acquired ": 18.472107891819284, "Hepatic cancer ": 8.954113847391804, "Hepatic cirrhosis ": 17.91011149176656, "Hepatic enzyme increased ": 2.0664092384616937, "Hepatic failure ": 5.241794303683563, "Hepatic function abnormal ": 3.891896903411976, "Hepatitis B ": 113.90205205799128, "Hepatitis B DNA increased ": 398.5147792574245, "Hepatitis B reactivation ": 137.78668538384193, "Hepatocellular carcinoma ": 9.974535134057517, "Hypophosphataemia ": 83.70592078534567, "Jaundice ": 5.625254493717801, "Lactic acidosis ": 6.878527305442215, "Multiple-drug resistance ": 19.48396269195553, "Osteomalacia ": 48.0659823795009, "Pathogen resistance ": 39.47302722295338, "Periorbital swelling ": 21.459340586837158, "Platelet count decreased ": 2.592392256979099, "Pregnancy ": 18.56908384486345, "Protein urine present ": 42.48409458101086, "Proteinuria ": 6.678567825246477, "Rash maculo-papular ": 2.4812485812290936, "Renal impairment ": 5.902828834539954, "Rhabdomyolysis ": 3.788695308583685, "Skin plaque ": 14.51597262873656, "Swelling face ": 2.182795241707037, "Therapeutic response decreased ": 6.628839912534524, "Thrombocytopenia ": 2.1677032251895287, "Transaminases increased ": 3.805537940140349, "Treatment noncompliance ": 4.781881495143108, "Viral load increased ": 102.31203578379056, "Viral mutation identified ": 71.60971291362493, "Virologic failure ": 57.82476222836497} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/408.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/408.json new file mode 100644 index 00000000000..e33d76056aa --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/408.json @@ -0,0 +1 @@ +{"Activated partial thromboplastin time prolonged ": 2.617762956053923, "Acute kidney injury ": 5.707418540045119, "Acute pulmonary oedema ": 9.137260959862836, "Akinesia ": 4.05736747784321, "Amyloidosis ": 7.154680796279707, "Angioedema ": 8.961703665004547, "Anuria ": 4.921701033935137, "Aortic stenosis ": 3.4958651742543574, "Aortic valve calcification ": 17.68778272181648, "Aortic valve incompetence ": 9.979374345995724, "Arrhythmic storm ": 20.15894567754527, "Arterial haemorrhage ": 5.577796016698047, "Asthma-chronic obstructive pulmonary disease overlap syndrome ": 18.042183582852, "Atrial enlargement ": 21.46485247400659, "Atrial fibrillation ": 3.7706376588443553, "Atrial flutter ": 3.9373078428742767, "Atrioventricular block ": 2.6746104957443557, "Atrioventricular block first degree ": 3.1617787388566314, "Azotaemia ": 3.160396016433929, "Bleeding time prolonged ": 5.182148408632219, "Blood chloride decreased ": 4.229118504721679, "Blood chloride increased ": 16.278540927303148, "Blood creatine increased ": 13.36585830485748, "Blood creatinine abnormal ": 3.678835301739419, "Blood creatinine decreased ": 2.5258460839354218, "Blood creatinine increased ": 9.478057482141944, "Blood iron decreased ": 3.172002068758169, "Blood phosphorus increased ": 4.185427107854594, "Blood potassium abnormal ": 4.0394517099962135, "Blood potassium decreased ": 2.6413713536654835, "Blood potassium increased ": 29.696279267929608, "Blood pressure abnormal ": 5.915922562817076, "Blood pressure decreased ": 9.148640312502266, "Blood pressure diastolic decreased ": 5.326675410249894, "Blood pressure fluctuation ": 2.816196528686957, "Blood pressure systolic abnormal ": 5.338238989462096, "Blood pressure systolic decreased ": 47.24903908371801, "Blood pressure systolic increased ": 3.821362865648435, "Blood sodium decreased ": 4.038709982335565, "Blood triglycerides increased ": 3.1193379666092924, "Blood urea increased ": 9.26840210392079, "Blood urea nitrogen/creatinine ratio increased ": 14.509370548118682, "Blood uric acid increased ": 5.993897309208055, "Body mass index decreased ": 58.2699137992591, "Brain natriuretic peptide abnormal ": 31.065263152780187, "Brain natriuretic peptide increased ": 22.80125123847497, "Breath sounds abnormal ": 3.007565562611109, "Bronchial hyperreactivity ": 7.795532045927324, "Bundle branch block left ": 11.71035244551503, "Cardiac disorder ": 2.196983400708476, "Cardiac dysfunction ": 23.83435988466822, "Cardiac failure ": 19.2762280312126, "Cardiac failure acute ": 13.252002112572542, "Cardiac failure chronic ": 37.40315701387538, "Cardiac failure congestive ": 3.197487178637858, "Cardiac function test abnormal ": 51.483650746269966, "Cardiac murmur ": 2.148472368833928, "Cardiac output decreased ": 9.904013835479198, "Cardiac ventricular disorder ": 26.397360822912308, "Cardiac ventricular thrombosis ": 2.868965788929204, "Cardiogenic shock ": 8.206561567190434, "Cardiomegaly ": 3.8053994364115713, "Cardiomyopathy ": 7.454447152644716, "Cardiorenal syndrome ": 48.39212622070965, "Cardiovascular insufficiency ": 3.683105492181041, "Computerised tomogram heart abnormal ": 83.59527123745303, "Concomitant disease aggravated ": 4.149549186116058, "Congestive hepatopathy ": 8.384737529573558, "Contraindicated product administered ": 6.692959633049774, "Cough ": 2.4542329062700814, "Craniocerebral injury ": 4.222639285865616, "Creatinine renal clearance decreased ": 3.23681990328769, "Creatinine renal clearance increased ": 5.73173930702683, "Death ": 2.4896024292829377, "Dehydration ": 2.7876152752050283, "Dementia ": 2.07362891943684, "Device inappropriate shock delivery ": 245.0806903727404, "Diastolic dysfunction ": 14.840339271146098, "Dilatation atrial ": 13.473400645138348, "Dilated cardiomyopathy ": 14.265133013679788, "Dizziness postural ": 4.6962221369103645, "Dyslipidaemia ": 3.799857783534837, "Dyspnoea at rest ": 6.922070749485373, "Dyspnoea exertional ": 2.944505933026446, "Dyspnoea paroxysmal nocturnal ": 19.07967881430109, "Ejection fraction ": 6.896740868282619, "Ejection fraction abnormal ": 35.7475720262455, "Ejection fraction decreased ": 32.600404703756325, "Electrocardiogram ST segment elevation ": 3.4663151846904494, "Electrocardiogram T wave inversion ": 6.10130576216825, "Electrocardiogram abnormal ": 2.6627722430024354, "Erysipelas ": 2.421818471548661, "Essential hypertension ": 3.5948513258117534, "Exercise tolerance decreased ": 3.177245322363361, "Faeces hard ": 2.565934927019133, "Feeling abnormal ": 2.097388170792456, "Fluid intake reduced ": 5.647244532364818, "Fluid retention ": 4.289573985110072, "General physical condition abnormal ": 4.123896193324312, "General physical health deterioration ": 2.3548803371662985, "Glomerular filtration rate abnormal ": 4.997079519827066, "Glomerular filtration rate decreased ": 35.55669847920228, "Glomerular filtration rate increased ": 9.25722964247403, "Gout ": 4.925266766803385, "Gynaecomastia ": 4.515124351117639, "Haematocrit decreased ": 3.153285875838852, "Haemoglobin increased ": 3.014614820253325, "Head injury ": 2.1249779247579745, "Heart failure with preserved ejection fraction ": 30.516256251498195, "Heart failure with reduced ejection fraction ": 56.69108818540332, "Heart rate abnormal ": 4.122690429358669, "Heart rate decreased ": 4.860297003144631, "Heart rate irregular ": 3.0873467514235187, "High density lipoprotein decreased ": 13.061225053515928, "Hyperkalaemia ": 19.19636968435838, "Hypertensive heart disease ": 12.308155954952712, "Hypervolaemia ": 9.188865675520768, "Hypochromasia ": 110.26949182621678, "Hypokinesia ": 3.0643111319493146, "Hypotension ": 15.414840668493111, "Hypovolaemia ": 6.750063890942708, "Hypovolaemic shock ": 2.0526053614482795, "Implantable defibrillator insertion ": 7.521236884866854, "Inappropriate schedule of product administration ": 3.678077890179571, "Incorrect dosage administered ": 2.2431440202247144, "Incorrect dose administered ": 2.03495480429601, "Infarction ": 2.5990211841000885, "International normalised ratio abnormal ": 2.113247653499666, "International normalised ratio fluctuation ": 5.142195874885386, "Ischaemic cardiomyopathy ": 19.16912200475098, "Ischaemic hepatitis ": 10.09415479386784, "Left atrial dilatation ": 13.847323651152758, "Left atrial enlargement ": 30.113201636170395, "Left ventricular dilatation ": 26.345040155626634, "Left ventricular dysfunction ": 16.764707657584573, "Left ventricular enlargement ": 67.98384027123443, "Left ventricular failure ": 3.863290671981001, "Left ventricular hypertrophy ": 6.928718050347364, "Lip swelling ": 4.290892154531568, "Lymphocyte count decreased ": 2.484464169302409, "Lymphocyte percentage decreased ": 6.499894652432314, "Mean platelet volume increased ": 43.03522717998387, "Meniscus injury ": 2.832516971038215, "Mitral valve incompetence ": 12.87866634901938, "Mitral valve thickening ": 147.5725274569521, "Myocardial infarction ": 2.363289624422017, "Myocardial ischaemia ": 2.1172057876936594, "N-terminal prohormone brain natriuretic peptide increased ": 100.90825695767376, "Nasal pruritus ": 5.141645180688413, "Near death experience ": 15.058884646759312, "Neutrophil count increased ": 3.0112822457471373, "Nipple pain ": 3.6366776258785545, "Nocturia ": 2.5170997443812606, "Normochromic anaemia ": 13.617549779275077, "Oedema ": 3.962296584273642, "Oedema peripheral ": 3.797685865757976, "Oliguria ": 2.3769549331181525, "Orthopnoea ": 22.99954149103805, "Orthostatic hypotension ": 6.107235749936124, "Pollakiuria ": 2.604135152429276, "Polyuria ": 5.092098920893879, "Prerenal failure ": 4.001117735199706, "Prescribed underdose ": 12.828336572077127, "Product monitoring error ": 11.71672629759177, "Product prescribing error ": 7.364862618951516, "Product use in unapproved indication ": 2.26039730538447, "Pruritus ": 2.2049266412573343, "Pulmonary congestion ": 4.078697337071549, "Pulmonary function test abnormal ": 5.357829792949751, "Pulmonary hypertension ": 3.667162414004477, "Pulmonary oedema ": 3.815517905871005, "Radius fracture ": 4.409715182969413, "Rales ": 5.769772770862655, "Red cell distribution width increased ": 11.609380249174064, "Renal disorder ": 3.146799927914082, "Renal failure ": 4.468865087174, "Renal function test abnormal ": 5.806817070336124, "Renal impairment ": 9.955752740250624, "Right atrial enlargement ": 21.581307794944863, "Right ventricular dysfunction ": 9.651148461207525, "SARS-CoV-2 test ": 27.96750828522805, "Scan myocardial perfusion ": 363.8191432832047, "Sinus bradycardia ": 3.0761555731222883, "Sudden cardiac death ": 9.954921975853894, "Sudden death ": 5.656351127387332, "Swelling face ": 2.654290262407296, "Swollen tongue ": 3.5034004295996666, "Systolic dysfunction ": 11.076860304589946, "Throat clearing ": 17.351382960204543, "Traumatic intracranial haemorrhage ": 8.014231865138628, "Tricuspid valve incompetence ": 11.18877834642918, "Underdose ": 7.808026541715906, "Upper respiratory tract inflammation ": 7.829788801541455, "Urine output decreased ": 4.677211542612704, "Urine output increased ": 4.504381016562586, "Vasoplegia syndrome ": 8.429467771479342, "Vein disorder ": 2.562815872808366, "Venous pressure jugular decreased ": 162.2718563149147, "Venous pressure jugular increased ": 35.229315701683525, "Ventricular arrhythmia ": 4.719421345014501, "Ventricular extrasystoles ": 5.12228443675819, "Ventricular fibrillation ": 3.982400600795079, "Ventricular hyperkinesia ": 86.58848158698123, "Ventricular hypokinesia ": 5.468852504959744, "Ventricular tachycardia ": 8.380094961380163, "Viral diarrhoea ": 57.868689420113824, "Weight fluctuation ": 8.420773088242267, "Weight increased ": 2.5407256681916643, "Wrong technique in product usage process ": 13.034081218463443} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/409.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/409.json new file mode 100644 index 00000000000..02b94bdae5b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/409.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 11.885365636094624, "Abdominal distension ": 2.6594084829990634, "Abdominal pain ": 2.8281156138463266, "Abdominal pain lower ": 2.6215047175648385, "Abnormal faeces ": 5.567865820834672, "Abortion spontaneous ": 3.2589633691132947, "Abscess ": 9.92959164608, "Abscess intestinal ": 34.78200113140713, "Acne ": 4.775239499533394, "Adenocarcinoma of colon ": 13.491180964646931, "Adverse drug reaction ": 2.8201032404689097, "Anal abscess ": 46.87329115799282, "Anal fissure ": 15.457887635142932, "Anal fistula ": 37.930542835594586, "Anal incontinence ": 4.069630284296669, "Anal inflammation ": 22.93618007380296, "Anal ulcer ": 16.063526203084294, "Ankylosing spondylitis ": 4.701029525624019, "Anorectal discomfort ": 7.912944950868469, "Anorectal disorder ": 12.5020718549913, "Appendicitis ": 4.494765027478689, "Arthritis ": 2.1650567359660524, "Autoimmune haemolytic anaemia ": 2.624947056212548, "B-cell lymphoma ": 4.318384569045144, "Bacillus infection ": 102.88609375192576, "Bacterial vulvovaginitis ": 220.71514649729505, "Blood iron decreased ": 4.058160068064939, "Bowel movement irregularity ": 6.072757220540931, "Breast cancer female ": 2.0726610378330133, "Breast cancer stage II ": 3.2361674379192857, "C-reactive protein increased ": 2.044240116602396, "Calcium deficiency ": 20.190796838059963, "Cataract ": 2.1130708822086794, "Cellulitis ": 2.261045036874991, "Central obesity ": 51.167153941902775, "Cholangitis ": 2.340651189596253, "Cholangitis sclerosing ": 31.794912798096867, "Cholecystectomy ": 2.7440029379404693, "Clostridium difficile infection ": 12.701249913690836, "Colectomy ": 54.76873175522815, "Colitis ": 6.307296503352374, "Colitis ulcerative ": 71.68411751356084, "Colon cancer ": 3.0378295529586, "Colonic abscess ": 25.91822610262592, "Condition aggravated ": 2.03123802190726, "Coronavirus infection ": 2.351810579779401, "Crohn's disease ": 43.6110062316749, "Cushingoid ": 16.90867591670899, "Cutaneous vasculitis ": 3.0080387529807835, "Cytomegalovirus colitis ": 8.801311563677947, "Cytomegalovirus enterocolitis ": 17.604648125731924, "Cytomegalovirus infection ": 4.111266563308093, "Defaecation urgency ": 38.80902748119965, "Device leakage ": 3.0842280594774034, "Diarrhoea haemorrhagic ": 17.850853444535716, "Dislocation of vertebra ": 2.890839680098303, "Drug effect less than expected ": 18.34997703813664, "Drug hypersensitivity ": 2.294126974687248, "Drug ineffective ": 2.553676136961116, "Drug level below therapeutic ": 4.904884013450886, "Drug level decreased ": 17.02778537103065, "Drug specific antibody present ": 47.27323205432713, "Dyschezia ": 12.19528821152895, "Ear infection ": 3.068968007253585, "Eastern Cooperative Oncology Group performance status worsened ": 9.53971939204578, "Enteritis ": 6.37977261619378, "Enteritis infectious ": 9.829030077610696, "Enterocutaneous fistula ": 26.70261704398224, "Eosinophilic pneumonia ": 3.9585279144011016, "Epstein-Barr virus infection ": 3.101855321832678, "Erythema nodosum ": 11.648051388012092, "Escherichia infection ": 9.096285215324576, "Faecal calprotectin abnormal ": 87.0223080114107, "Faecal calprotectin increased ": 76.9701781326249, "Faeces hard ": 5.766441460172619, "Faeces soft ": 11.18530217537436, "Female genital tract fistula ": 2.098364443008101, "Fistula ": 21.336964819544228, "Flatulence ": 4.684183963464483, "Frequent bowel movements ": 28.086848544392943, "Furuncle ": 12.67254366788747, "Gastroenteritis eosinophilic ": 30.839229154454127, "Gastroenteritis viral ": 2.3124727748613227, "Gastrointestinal infection ": 4.301088094830861, "Gastrointestinal inflammation ": 19.3713413801621, "Gastrointestinal mucosa hyperaemia ": 46.57399219960523, "Gastrointestinal pain ": 2.313433448755051, "Gastrointestinal ulcer ": 17.236869574978247, "Gastrointestinal wall thickening ": 24.172254056166583, "General symptom ": 7.037574120874548, "Granuloma ": 3.609249612532609, "Haematochezia ": 11.757112570471056, "Haemorrhoids ": 3.037647562333887, "Hidradenitis ": 7.241624454815877, "Histoplasmosis ": 21.15975744220787, "Hunger ": 2.065350345306928, "Ileal stenosis ": 79.9316154158349, "Ileostomy ": 14.753470634160829, "Immune thrombocytopenia ": 2.5218566273135266, "Immunosuppression ": 2.517512360658384, "Impaired quality of life ": 4.279331695949424, "Inflammatory bowel disease ": 22.88699060419961, "Infusion related reaction ": 2.194005238893579, "Infusion site extravasation ": 4.644557222129218, "Infusion site pain ": 3.2856747155776302, "Injection site discharge ": 98.52879303103236, "Injection site extravasation ": 5.790616425687328, "Injection site hypersensitivity ": 8.129733841708733, "Injection site oedema ": 2.949061574053319, "Injection site pruritus ": 2.283538979808633, "Injection site rash ": 2.772123554064716, "Injection site reaction ": 2.7560688709137806, "Injection site urticaria ": 5.094081222385403, "Intestinal fistula ": 31.506642033526965, "Intestinal obstruction ": 9.287204766367726, "Intestinal perforation ": 2.1917088487797582, "Intestinal resection ": 33.802855059443964, "Intestinal stenosis ": 59.98262235847874, "Intestinal ulcer ": 16.303260633182845, "Iron deficiency ": 7.687127818665867, "JC polyomavirus test positive ": 37.41776843719308, "Large intestinal stenosis ": 38.98175621252901, "Large intestinal ulcer ": 11.661997530901298, "Large intestine perforation ": 3.0286660965271777, "Large intestine polyp ": 4.29907206738235, "Liver abscess ": 4.679804849207558, "Loss of therapeutic response ": 70.2541207970881, "Lower respiratory tract infection ": 2.8379438517107607, "Lupus-like syndrome ": 11.815927657211178, "Malnutrition ": 3.182103693668411, "Maternal exposure during breast feeding ": 2.114787289082662, "Mouth ulceration ": 3.5568019443972068, "Mucous stools ": 46.74572706225303, "Nasopharyngitis ": 3.1134567434864557, "Nipple pain ": 4.679804849207558, "Off label use ": 4.022212075234344, "Organising pneumonia ": 3.442931792742111, "Overgrowth bacterial ": 56.09709914828749, "Pharyngitis ": 2.016090287879069, "Pharyngitis streptococcal ": 4.280214924962643, "Platelet count increased ": 2.3382265826720823, "Polyp ": 2.6332618598522437, "Poor venous access ": 35.361104321313995, "Pouchitis ": 112.82113200213136, "Pre-eclampsia ": 2.262724999034128, "Pregnancy ": 49.55700468164199, "Proctalgia ": 8.529521921051762, "Proctitis ": 10.372175913626387, "Product administered to patient of inappropriate age ": 6.087613074228484, "Product dispensing error ": 2.6906942033592443, "Progressive multifocal leukoencephalopathy ": 4.6548154297163205, "Pulmonary toxicity ": 3.495428154083084, "Pyoderma gangrenosum ": 34.65867043786974, "Rectal abscess ": 16.549424687384747, "Rectal haemorrhage ": 5.321300057264114, "Rectal tenesmus ": 11.869816682032242, "Sacroiliitis ": 7.678206294414727, "Sinus congestion ": 2.7544747357014248, "Sinusitis ": 2.9998766469928646, "Skin infection ": 3.63556538695333, "Skin reaction ": 2.0301398975925653, 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4.879298707354844, "Urinary tract infection ": 2.166459099896034, "Uveitis ": 3.566458333413661, "Weight fluctuation ": 3.0078092019056752} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/41.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/41.json new file mode 100644 index 00000000000..37da0ce9ef4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/41.json @@ -0,0 +1 @@ +{"Chest pain ": 2.0644040767882013, "Hypertension ": 2.7938050323032027, "Migraine ": 6.846093138431921, "Paraesthesia ": 2.8224126900494286, "Tinnitus ": 5.60158434147851} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/410.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/410.json new file mode 100644 index 00000000000..a5bef21f684 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/410.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 9.34802797271922, "Ascites ": 22.175002988121147, "Cardiac failure congestive ": 11.048272480415577, "Cardiomegaly ": 63.15613650567877, "Coronavirus infection ": 170.60553019527586, "Cough ": 2.138413298817364, "Drug interaction ": 5.816056793342344, "Drug level increased ": 98.44054676239128, "Dysphagia ": 8.96625979299257, "Haemoptysis ": 26.029058926580912, "Hypoglycaemia ": 4.931146788071819, "Immunosuppressant drug level increased ": 292.806821929976, "Inflammatory marker increased ": 179.42922398324947, "Labelled drug-drug interaction medication error ": 48.53508073081731, "Leukopenia ": 8.228827180716044, "Lower respiratory tract infection ": 19.765855286211934, "Lung consolidation ": 334.1482293927682, "Multimorbidity ": 960.2672617602084, "Myocardial ischaemia ": 67.86487204535443, "Oesophageal carcinoma ": 73.47984765264044, "Oesophageal perforation ": 1472.667815408806, "Off label use ": 3.501873125417027, "Pleural effusion ": 13.451571400694606, "Pneumonia ": 4.257978971336005, "Productive cough ": 20.920691495028183} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/411.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/411.json new file mode 100644 index 00000000000..81860d884ec --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/411.json @@ -0,0 +1 @@ +{"Acute myocardial infarction ": 2.11438949342669, "Amnesia ": 2.617336120980133, "Asthenia ": 2.531134296221345, "Bone pain ": 2.212184549356868, "Cardiac failure congestive ": 3.216598003308982, "Cognitive disorder ": 3.4751226011348493, "Constipation ": 2.8312609803086417, "Dehydration ": 2.584430308430509, "Drug interaction ": 4.238820824172262, "Erectile dysfunction ": 2.9694318195545573, "Faeces discoloured ": 4.086715239920283, "Fall ": 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new file mode 100644 index 00000000000..097f8688a14 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/412.json @@ -0,0 +1 @@ +{"Angina pectoris ": 43.61989143589956, "Anxiety disorder ": 445.15862442643135, "Cellulitis ": 51.347739721160735, "Chest pain ": 7.247263622297539, "Chronic obstructive pulmonary disease ": 45.24116119535811, "Delirium ": 43.54642460147096, "Dementia Alzheimer's type ": 309.6623483634038, "Dermatitis atopic ": 403.043666715322, "Dyspepsia ": 25.38729919319676, "Haemorrhoids ": 104.38002836808998, "Hypothyroidism ": 38.0176560464381, "Iron deficiency anaemia ": 266.4204276526159, "Lung neoplasm malignant ": 75.57418514590347, "Metastatic neoplasm ": 756.3507176705792, "Pleural effusion ": 34.517328009414946, "Rash ": 3.432942976110694, "Schizophrenia ": 237.7034715968642, "Urinary tract infection ": 22.01120359325052, "Vitamin D deficiency ": 131.92898654040428} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/413.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/413.json new file mode 100644 index 00000000000..3c96b4d169c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/413.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 2.4904397223012094, "Ascites ": 13.8641180105857, "Blood bilirubin increased ": 4.663020411974359, "Circumstance or information capable of leading to medication error ": 12.398339783711886, "Death ": 2.4303649030213617, "Drug ineffective ": 9.002255395620162, "Encephalopathy ": 3.036195173689428, "Genotype drug resistance test positive ": 230.96761373882345, "Glomerular filtration rate decreased ": 5.476512084250556, "Hepatic cancer ": 7.215967324859996, "Hepatic cirrhosis ": 29.92627406492871, "Hepatic encephalopathy ": 25.13926692887764, "Hepatic failure ": 9.257989010077388, "Hepatitis B reactivation ": 9.815736919356604, "Hepatitis C ": 135.3773960995886, "Hepatitis C RNA positive ": 115.41334055001042, "Hepatitis C virus test positive ": 198.68358075290303, "Hepatocellular carcinoma ": 28.278685580557507, "Hepatorenal syndrome ": 24.785368289088403, "Incorrect product administration duration ": 4.173362157845683, "Intentional dose omission ": 41.02321788655625, "Intentional product use issue ": 3.967335430354284, "Liver disorder ": 2.227469251051033, "Liver transplant ": 57.531365047012585, "Oesophageal varices haemorrhage ": 32.49532311478416, "Product dose omission in error ": 7.067992508614373, "Product dose omission issue ": 3.3446125994245626, "Product use complaint ": 8.17758403890649, "Psychotic disorder ": 2.4212661204007366, "Spontaneous bacterial peritonitis ": 72.47677420815941, "Treatment failure ": 56.59400110519505, "Treatment noncompliance ": 12.993678037807232, "Varices oesophageal ": 27.045297843789857, "Virologic failure ": 11.769276594698924} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/414.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/414.json new file mode 100644 index 00000000000..3fa369f3083 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/414.json @@ -0,0 +1 @@ +{"C-reactive protein increased ": 11.71254140234428, "COVID-19 ": 3.060116380183333, "COVID-19 pneumonia ": 49.54761825988718, "Cytokine release syndrome ": 379.7417768100353, "Decreased appetite ": 2.364031734593481, "Diffuse large B-cell lymphoma ": 159.19376077073815, "Disease progression ": 3.6644220636030767, "Febrile neutropenia ": 16.946923541004338, "Hypotension ": 3.231437207368858, "Immune effector cell-associated neurotoxicity syndrome ": 150.5355155179341, "Malignant neoplasm progression ": 3.0098643443827173, "Neutropenia ": 3.7494234332082654, "Neutrophil count decreased ": 10.345268278557809, "Pneumonia ": 8.065252755109903, "Pyrexia ": 2.1740585214328405, "Sepsis ": 4.944034668691656} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/415.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/415.json new file mode 100644 index 00000000000..e628e695625 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/415.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 15.059179866566067, "Aggression ": 15.259360716774268, "Agitation ": 4.205031584680556, "Alanine aminotransferase increased ": 5.166685887179913, "Aspartate aminotransferase increased ": 4.207544208629049, "Condition aggravated ": 3.055847864664908, "Decreased appetite ": 4.6146235743076485, "Diarrhoea ": 2.476506055044936, "Drug ineffective ": 2.047575390866384, "Drug interaction ": 5.851466728703322, "Epilepsy ": 11.781796004675943, "Gait disturbance ": 3.542660249876295, "Generalised tonic-clonic seizure ": 9.221365612661124, "Hepatic enzyme increased ": 4.403209668746546, "Irritability ": 9.332812909565618, "Off label use ": 2.028932056195232, "Overdose ": 5.686020081046888, "Product use in unapproved indication ": 3.8852661600978617, "Sedation ": 45.62015425726177, "Seizure ": 13.843303593399268, "Somnolence ": 8.75558967888187, "Therapeutic response unexpected ": 31.182571112175136, "Weight decreased ": 2.4581375408619914} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/416.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/416.json new file mode 100644 index 00000000000..af4febb92fd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/416.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.3277789678622307, "Haemoglobin decreased ": 5.601204371698806, "Hepatic function abnormal ": 8.258949751227288, "Myelosuppression ": 123.38111695133507, "Neutrophil count decreased ": 43.10991943446583, "Off label use ": 3.2390669510034806, "Platelet count decreased ": 11.678395770816712, "Vomiting ": 3.3432163675487208, "White blood cell count decreased ": 50.06382320888917} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/417.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/417.json new file mode 100644 index 00000000000..4ffd9fec245 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/417.json @@ -0,0 +1 @@ +{"Abortion ": 13.029016481270984, "Abortion induced ": 5.778234555351153, "Abortion spontaneous ": 2.824132659772705, "Abulia ": 28.384495193864304, "Alanine aminotransferase increased ": 4.515731423604952, "Amylase increased ": 7.52748075588499, "Anaemia ": 3.917801383436789, "Anaemia macrocytic ": 20.41601545663509, "Ascites ": 2.423103024940346, "Aspartate aminotransferase increased ": 4.619391561027788, "Atrial septal defect ": 7.336026015714461, "Blood HIV RNA increased ": 28.836376872901727, "Blood alkaline phosphatase increased ": 5.688429452210458, "Blood bilirubin increased ": 3.3208884934792406, "Blood creatine phosphokinase increased ": 4.994035138708592, "Blood creatinine increased ": 2.6522426184794075, "Blood culture positive ": 26.825761801253947, "Blood lactate dehydrogenase increased ": 5.323866467033643, "Blood lactic acid increased ": 36.96344941393885, "Blood triglycerides increased ": 7.853861671449067, "Brain death ": 15.313579017993831, "Breast enlargement ": 10.050274068551545, "Caesarean section ": 15.167831135866484, "Candida infection ": 2.671800635708834, "Cardiac murmur ": 3.982613329617241, "Cardiomyopathy ": 4.148974458859302, "Central nervous system lymphoma ": 38.90920211271096, "Cerebral toxoplasmosis ": 90.456990882979, "Cholestasis ": 2.3943419227750757, "Coronary artery disease ": 2.7273975375667847, "Depressive symptom ": 7.813857619497842, "Developmental delay ": 8.52934270670302, "Diabetes mellitus ": 8.010185872004477, "Disorientation ": 2.6282082386729706, "Disseminated intravascular coagulation ": 2.0704977563861364, "Drug resistance ": 3.809719538367165, "Dyslipidaemia ": 4.8798026076846375, "Facial wasting ": 197.20698136397948, "Failure to thrive ": 14.384959634017967, "Foetal exposure during pregnancy ": 7.530997689333515, "Foetal growth restriction ": 5.410604103513777, "Gamma-glutamyltransferase increased ": 6.249540266558678, "Guillain-Barre syndrome ": 2.279550551440222, "Haemophagocytic lymphohistiocytosis ": 5.60846677252474, "Hepatic cirrhosis ": 10.081449847375742, "Hepatic failure ": 5.158185731886874, "Hepatic function abnormal ": 3.12602261018401, "Hepatic steatosis ": 12.599659604994558, "Hepatitis ": 4.135144464804229, "Hepatitis B ": 15.767705158215668, "Hepatitis C ": 2.395455472995975, "Hepatitis cholestatic ": 6.619742538631544, "Hepatitis fulminant ": 10.874454746272315, "Hepatomegaly ": 8.620628971074215, "Hepatosplenomegaly ": 14.536455110451652, "Herpes virus infection ": 6.384761337558008, "Hyperbilirubinaemia ": 8.815671634720543, "Hypercholesterolaemia ": 14.79790248279143, "Hyperlactacidaemia ": 45.66328965745541, "Hyperlipidaemia ": 2.963032159665238, "Hyperreflexia ": 12.526994702101018, "Hyperthyroidism ": 2.349410922065468, "Hypertonia ": 6.0388137392567, "Hypertriglyceridaemia ": 51.79666303790715, "Hypophagia ": 2.760550249175187, "Immune reconstitution inflammatory syndrome ": 60.00885722172054, "JC virus infection ": 38.38209824326554, "Jaundice ": 2.042905083610589, "Lactic acidosis ": 15.513690838318295, "Leukopenia ": 4.605438958206982, "Lipase increased ": 9.724482354172173, "Lipoatrophy ": 190.60670605547568, "Lipodystrophy acquired ": 91.77322139930904, "Live birth ": 6.587160846630346, "Locked-in syndrome ": 129.8796683858363, "Low birth weight baby ": 7.499620128094573, "Lung infiltration ": 5.115284128498868, "Lymphoma ": 3.4342327172845644, "Macrocytosis ": 33.722367037941495, "Metabolic acidosis ": 2.752790521771012, "Mycobacterium avium complex infection ": 22.917102689188237, "Myocardial infarction ": 2.395919733274142, "Nephrolithiasis ": 2.301547451766021, "Nervous system disorder ": 4.450318610071912, "Neuropathy peripheral ": 2.9641948363014445, "Neutropenia ": 3.829720291607889, "Oral candidiasis ": 4.697492849660551, "Osteonecrosis ": 2.667810004557924, "Pancreatitis ": 5.453320870769771, "Pancreatitis acute ": 2.743474523763604, "Pancytopenia ": 4.667102129145656, "Patent ductus arteriosus ": 9.991896921848657, "Pathogen resistance ": 7.643189522437596, "Placental disorder ": 34.128575768762055, "Pneumocystis jirovecii pneumonia ": 9.083205861262153, "Portal hypertension ": 18.97363116246328, "Pregnancy ": 25.296389568421983, "Premature baby ": 7.312124600425434, "Premature delivery ": 11.130256088603078, "Premature rupture of membranes ": 17.51643184253225, "Progressive multifocal leukoencephalopathy ": 17.022703380064378, "Pulmonary hypertension ": 3.183165601144518, "Renal impairment ": 3.2213529768719487, "Renal tubular necrosis ": 8.437768423092422, "Road traffic accident ": 3.20995362622218, "Shock ": 2.4972995614281515, "Skin ulcer ": 2.2922558938832016, "Speech disorder developmental ": 12.35470784800599, "Subdural haematoma ": 2.282145280074888, "Sudden death ": 3.73143393117829, "Tuberculosis ": 14.217524984773917, "Varices oesophageal ": 35.63120988309785, "Ventricular tachycardia ": 2.4952011923170843, "Virologic failure ": 7.575623127779882} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/418.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/418.json new file mode 100644 index 00000000000..76931d5f25a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/418.json @@ -0,0 +1 @@ +{"Abdominal pain ": 4.483985858295148, "Anaemia ": 6.181664173220954, "Anti-erythropoietin antibody negative ": 675.2947513744114, "Anti-erythropoietin antibody positive ": 349.5703420902292, "Aplasia pure red cell ": 210.8803792217742, "Bone marrow failure ": 17.292079470352064, "Bone pain ": 2.433837319595624, "Deep vein thrombosis ": 2.58090204766743, "Device interaction ": 9632.533523763224, "Diarrhoea ": 2.699134427406748, "Drug ineffective ": 2.362400069518772, "Drug specific antibody absent ": 143.78375634679756, "Exposure during pregnancy ": 2.7412136027599825, "Foetal exposure during pregnancy ": 4.360072085638552, "Haematocrit decreased ": 9.229948820867802, "Haemoglobin decreased ": 11.75485243820902, "Hypersensitivity ": 6.2048405343566255, "Hypotension ": 5.980132697694561, "Live birth ": 21.275077080012537, "Low birth weight baby ": 13.5985602262372, "Maternal exposure during pregnancy ": 4.690423265148625, "Myelodysplastic syndrome ": 12.66255227373563, "Neutralising antibodies positive ": 361.4433936119351, "Platelet count decreased ": 12.326939414657756, "Premature baby ": 8.7230998826782, "Premature delivery ": 14.321792496065203, "Premature rupture of membranes ": 56.56878537110124, "Therapeutic response decreased ": 9.214228158083106, "Transfusion ": 24.32321647747281} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/419.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/419.json new file mode 100644 index 00000000000..0f116c39733 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/419.json @@ -0,0 +1 @@ +{"Drug ineffective ": 5.43782934777401, "Drug ineffective for unapproved indication ": 107.71962629765838, "Factor VIII inhibition ": 284.07402197546674, "Haemorrhage ": 35.604339240848724} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/42.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/42.json new file mode 100644 index 00000000000..0b1eb6d1982 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/42.json @@ -0,0 +1 @@ +{"Drug interaction ": 5.481900324478512, "Erythema ": 4.181759458317539} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/420.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/420.json new file mode 100644 index 00000000000..8a353542aaa --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/420.json @@ -0,0 +1 @@ +{"Chest pain ": 3.4146354594030828, "Haematoma ": 15.381040860995212, "Haemoglobin decreased ": 7.195146414091758, "Haemorrhage intracranial ": 73.12327039440846, "Pulmonary alveolar haemorrhage ": 105.89690505423144, "Thrombocytopenia ": 29.301225320252115} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/421.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/421.json new file mode 100644 index 00000000000..b0e5ce10bbc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/421.json @@ -0,0 +1 @@ +{"Acne ": 2.614319999142741, "Acute respiratory distress syndrome ": 5.644861881524675, "Alanine aminotransferase increased ": 2.584117202608483, "Anaemia ": 2.643481480846501, "Anaphylactic shock ": 2.1832359194945603, "Aspartate aminotransferase increased ": 2.1226259306709823, "Blood bilirubin increased ": 2.170288278862958, "Conjunctivitis ": 8.379775585948028, "Decreased appetite ": 2.335011738588211, "Dehydration ": 2.568889512851261, "Dermatitis ": 3.516965042932214, "Dermatitis acneiform ": 101.74043409911827, "Diarrhoea ": 3.385630733003297, "Disease progression ": 4.171495313099722, "Disseminated intravascular coagulation ": 5.349117565989818, "Dry skin ": 6.654729430906476, "Febrile neutropenia ": 5.136998285102881, "Granulocyte count 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"Treatment failure ": 8.157614729260038} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/423.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/423.json new file mode 100644 index 00000000000..89209b9f04d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/423.json @@ -0,0 +1 @@ +{"Abdominal pain ": 4.317675810106594, "Amenorrhoea ": 2.744479301086959, "Anuria ": 86.87076200210286, "Blood pressure increased ": 2.927533943060538, "Blood pressure measurement ": 88.48518702527767, "Constipation ": 6.208809158321023, "Contraindicated product administered ": 2.3810260812840407, "Cough ": 4.351272880755281, "Device malfunction ": 7.634974583620242, "Diarrhoea ": 2.16412275169804, "Drug ineffective ": 3.9287704909412513, "Drug ineffective for unapproved indication ": 42.24218600054092, "Drug intolerance ": 4.223786170108659, "Dyspepsia ": 13.2799086976483, "Extrapyramidal disorder ": 60.99521700526485, "Eye pain ": 2.568265196173149, "Fibromyalgia ": 4.311736226389039, "Head discomfort ": 4.594867889050179, "Migraine ": 22.81362551475834, "Migraine without aura ": 173.33544977004564, "Muscle spasms ": 2.310143198258543, "Myocardial oedema ": 248.40339966835413, "Neck pain ": 2.195195366040987, "Neovascularisation ": 1602.3203926596684, "Off label use ": 2.125172872971256, "Paradoxical drug reaction ": 303.9100530685184, "Photophobia ": 10.02704189224825, "Photopsia ": 19.81779697081929, "Poor quality sleep ": 7.247337913942489, "Product use issue ": 2.1036369800162222, "Raynaud's phenomenon ": 55.37720285797511, "Respiratory disorder ": 6.717266146899371, "Reversible cerebral vasoconstriction syndrome ": 84.96753267042453, "Swelling face ": 2.5246848672073106, "Therapeutic product effect decreased ": 2.475058937947217, "Therapeutic product effect incomplete ": 2.4787135928912334, "Treatment failure ": 17.35214544419118, "Weight decreased ": 5.705046965155704} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/424.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/424.json new file mode 100644 index 00000000000..b13724793a8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/424.json @@ -0,0 +1 @@ +{"Alopecia ": 3.04218782886829, "Anaemia ": 2.1406881740119044, "Asthenia ": 3.5859065693956387, "Breast cancer ": 7.494784919849463, "Breast cancer metastatic ": 56.213053812705134, "Disease progression ": 7.941998077327304, "Encephalitis herpes ": 454.3821086037361, "Febrile neutropenia ": 8.331747686386285, "Hepatic function abnormal ": 3.96687279735733, "Immunosuppression ": 103.42939245317604, "Interstitial lung disease ": 3.844302313135437, "Malignant neoplasm progression ": 16.817078574147903, "Metastases to bone ": 25.38961047309413, "Metastases to central nervous system ": 29.157739427233377, "Metastases to liver ": 35.45978175461751, "Myelosuppression ": 19.91577679508041, "Neoplasm progression ": 9.50096419372044, "Neuropathy peripheral ": 11.194772262742456, "Neutropenia ": 9.113234767801876, "Neutrophil count decreased ": 14.58383321600367, "Platelet count decreased ": 5.1369529092422965, "Pleural effusion ": 8.976950703173097, "Protein total increased ": 183.550213263826, "White blood cell count decreased ": 8.747986864174766} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/425.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/425.json new file mode 100644 index 00000000000..9e26dfeeb6e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/425.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/426.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/426.json new file mode 100644 index 00000000000..c916a9803b3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/426.json @@ -0,0 +1 @@ +{"Agranulocytosis ": 2.359840747130188, "Blood pressure systolic increased ": 2.989071122070139, "Blood thyroid stimulating hormone increased ": 6.171918724559681, "Blood triglycerides increased ": 2.954688166576865, "Cardiac failure ": 4.307459486215716, "Death ": 6.427121627956616, "Decreased appetite ": 2.425839623796797, "Dementia ": 2.9628039732118605, "Dermatitis allergic ": 2.5803450660117644, "Dermatitis exfoliative ": 12.692730411205076, "Dermatitis exfoliative generalised ": 15.82085825707848, "Disease progression ": 3.370860777925614, "Drug eruption ": 12.93590459405275, "Drug reaction with eosinophilia and systemic symptoms ": 9.465834980422398, "Dry skin ": 3.2248995108482728, "Dysphagia ": 3.2847993241693287, "Eczema ": 3.123227063737258, "Eosinophil count increased ": 9.165166724221438, "Erythema multiforme ": 8.62791842080411, "Fall ": 2.487953405077965, "Hospitalisation ": 2.01637817523183, "Hot flush ": 9.656146846893924, "Hypertension ": 2.608399803391388, "Hypothyroidism ": 9.61074919584059, "Interstitial lung disease ": 11.244950130255395, "Metastases to bone ": 13.247050129787748, "Metastases to lymph nodes ": 6.249677927040783, "Neoplasm malignant ": 2.164180853164125, "Oedema peripheral ": 2.464220997558076, "Prescribed underdose ": 8.501462338724695, "Prostate cancer ": 30.266294219724717, "Prostate cancer metastatic ": 211.62250043889804, "Prostatic specific antigen increased ": 83.62774384057815, "Rash ": 15.042335653212865, "Rash erythematous ": 4.299384290660118, "Rash maculo-papular ": 9.02704790942666, "Rash papular ": 2.353534581936578, "Rash pruritic ": 9.094641264583297, "Skin disorder ": 3.0769161763195068, "Skin exfoliation ": 3.586851519869861, "Skin reaction ": 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00000000000..90d2a94be04 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/429.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 3.8408930056094417, "Abdominal pain upper ": 2.5936633399688853, "Abnormal loss of weight ": 3.4065076003331902, "Acute respiratory failure ": 4.170461716051188, "Aortic aneurysm ": 6.36972424897701, "Appetite disorder ": 4.022294128035956, "Arteriosclerosis coronary artery ": 4.78500364079098, "Back injury ": 5.726245555203179, "Blood sodium decreased ": 4.045479122789641, "Brain neoplasm ": 2.0762734982602757, "Bronchitis ": 3.724276470447661, "Carbon dioxide increased ": 13.032532561579837, "Cardiac disorder ": 2.516440021759985, "Chest injury ": 8.853499990347881, "Chronic obstructive pulmonary disease ": 2.0358884471745107, "Chronic respiratory failure ": 16.04220473756539, "Constipation ": 2.5909421280546607, "Coronavirus infection ": 4.509321401296473, "Cough ": 3.023753929094348, "Cystitis ": 3.119046808669999, "Death ": 19.13302431129602, "Decreased appetite ": 6.434424581359943, "Diverticulitis ": 2.553161991828615, "Dry skin ": 3.751695226407764, "Dyspepsia ": 6.984396402429972, "Dyspnoea ": 2.3212403501405063, "Dyspnoea exertional ": 3.68963994656675, "Eructation ": 3.86903561573624, "Fall ": 2.15841525780157, "Feeding disorder ": 2.587783881382597, "Fibrosis ": 6.724899520768648, "Flatulence ": 3.69649103657628, "Forced vital capacity decreased ": 65.95745051705178, "Frustration tolerance decreased ": 2.8389036981061, "Gastrointestinal disorder ": 5.004814634191738, "Gastrooesophageal reflux disease ": 3.655058888598689, "Haemoptysis ": 3.423276868722763, "Heart valve incompetence ": 8.613462482769634, "Hernia ": 2.7973538346685576, "Hiatus hernia ": 2.212733849698695, "Hip fracture ": 2.4463346411128035, "Hyperchlorhydria ": 9.085421203680363, "Hypersomnia ": 2.149587151394568, "Hypophagia ": 2.218603879228362, "Hypoxia ": 3.453480625970981, "Idiopathic pulmonary fibrosis ": 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29.52444949458685, "Pulmonary hypertension ": 4.035586343209769, "Pulmonary oedema ": 2.9314609956326847, "Pulmonary pain ": 2.865370167294917, "Pulmonary thrombosis ": 4.371943654493496, "Rales ": 2.6413737004021782, "Respiratory disorder ": 3.012641738759477, "Respiratory failure ": 4.339606971047851, "Respiratory tract infection ": 3.218197350828289, "Rib fracture ": 2.731369791669115, "Secretion discharge ": 2.4721614474067963, "Sinus congestion ": 3.036420690062744, "Sinus disorder ": 2.092473032193897, "Skin cancer ": 2.956989328932642, "Skin discolouration ": 2.074626399166184, "Skin exfoliation ": 4.484367857591661, "Skin reaction ": 2.764968930462558, "Solar dermatitis ": 35.13612112450818, "Spinal fracture ": 3.0525121170706724, "Sputum discoloured ": 2.458611805945425, "Sunburn ": 48.76534194596079, "Taste disorder ": 2.501379468890061, "Transaminases increased ": 2.208255895342464, "Upper respiratory tract congestion ": 12.127159172464966, "Urinary tract infection ": 2.6492060212044946, "Walking aid user ": 7.902613951037277, "Walking distance test abnormal ": 52.48563694473251, "Weight decreased ": 7.55394360682067} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/43.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/43.json new file mode 100644 index 00000000000..d93147056a7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/43.json @@ -0,0 +1 @@ +{"Drug hypersensitivity ": 13.348327111296932, "Peripheral swelling ": 6.617030366243652, "Surgery ": 51.45540116473992} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/430.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/430.json new file mode 100644 index 00000000000..2f461add49d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/430.json @@ -0,0 +1 @@ +{"Drug resistance ": 236.10679660195305, "Suicidal ideation ": 84.48162649632071} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/431.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/431.json new file mode 100644 index 00000000000..60ba54adafe --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/431.json @@ -0,0 +1 @@ +{"Drug ineffective ": 5.093629950035385, "Off label use ": 5.2902055899497205, "Seizure ": 16.27583576751202} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/432.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/432.json new file mode 100644 index 00000000000..b95b58b74b9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/432.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.532660524676507, "Abdominal pain lower ": 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"Gamma-glutamyltransferase increased ": 14.908905864081284, "Haemangioma of liver ": 99.47312502887094, "Haemorrhage ": 2.41273149424914, "Heavy menstrual bleeding ": 3.937071567551048, "Hepatic enzyme increased ": 9.362555270490866, "Hepatic steatosis ": 7.925074418281881, "Hot flush ": 8.709152827239416, "Hypertransaminasaemia ": 11.116753889695987, "Intentional product use issue ": 19.525537612815267, "Intercepted product administration error ": 478.3268084470686, "Intermenstrual bleeding ": 5.503489464216597, "Labelled drug-drug interaction medication error ": 17.051385948802324, "Liver disorder ": 2.5057395282185007, "Liver function test abnormal ": 5.086456913606974, "Liver function test increased ": 6.076845977151445, "Maternal exposure before pregnancy ": 27.08950782560163, "Maternal exposure during pregnancy ": 2.3331818032683858, "Menometrorrhagia ": 15.82191013257609, "Mood swings ": 6.707144644639451, "Musculoskeletal pain ": 3.7393132635546578, "Ovarian cyst ": 43.09269855841772, "Pelvic pain ": 15.667663094590742, "Procedural complication ": 122.33656821287612, "Procedural haemorrhage ": 30.69483207240664, "Product administration error ": 14.64511411024511, "Pulmonary embolism ": 2.250017182493361, "Sarcoma uterus ": 887.0831012578955, "Transaminases increased ": 31.35775348740564, "Urinary incontinence ": 12.266455029975042, "Uterine haemorrhage ": 258.4913001725645, "Uterine leiomyoma ": 213.51712604834225, "Uterine leiomyoma necrosis ": 9645.11397923189, "Uterine myoma expulsion ": 5290.646315414552, "Uterine polyp ": 118.51616196599598, "Vaginal discharge ": 13.615477879323098, "Vaginal haemorrhage ": 10.216193869335347, "Vertigo ": 2.849356552112286, "Weight increased ": 3.4774879890319927} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/433.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/433.json new file mode 100644 index 00000000000..e3d5421b64c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/433.json @@ -0,0 +1 @@ +{"Abdominal pain lower ": 2.0938787412789925, "Acute kidney injury ": 8.693510529778885, "Adjustment disorder ": 15.268603145473364, "Affect lability ": 4.142772892000246, "Agranulocytosis ": 2.2987826791316937, "Anaemia macrocytic ": 10.613359171990984, "Aphthous ulcer ": 2.548313943292091, "Areflexia ": 27.869898043038837, "Arthritis ": 2.184613741701468, "Aspergillus infection ": 4.91561016242736, "Atelectasis ": 8.568907302197651, "Bile duct stone ": 14.208921112027156, "Blood pressure diastolic abnormal ": 20.007416103556096, "Blood pressure diastolic decreased ": 6.814384765010442, "Blood pressure systolic abnormal ": 20.35462290700057, "Blood pressure systolic increased ": 4.59373021950755, "Blood sodium increased ": 19.54787531681773, "Blood test abnormal ": 3.846413447961888, "Blood urea decreased ": 37.75534749967666, "Brain scan abnormal ": 370.049138546544, "Breath sounds abnormal ": 7.647203144882404, "Cardiogenic shock ": 2.0568882141465634, "Carpal tunnel syndrome ": 4.559309149915089, "Cerebral artery thrombosis ": 139.14963079593562, "Cholestasis ": 5.365756542957679, "Chondropathy ": 25.659009496854104, "Chronic fatigue syndrome ": 4.435906274568137, "Chronic sinusitis ": 5.115054897442563, "Clostridium difficile colitis ": 3.758479670239105, "Coma scale abnormal ": 6.426202186288534, "Completed suicide ": 3.9238201297491737, "Concussion ": 14.395775859399857, "Cutaneous vasculitis ": 3.151614592849884, "Dehydration ": 2.128004273215487, "Delirium ": 3.097002846081021, "Disease recurrence ": 2.617283852208753, "Drug eruption ": 2.120937576076269, "Drug interaction ": 5.776522052262055, "Drug level increased ": 3.4827426274030016, "Drug reaction with eosinophilia and systemic symptoms ": 5.357720300893071, "Drug-induced liver injury ": 3.0521509343829667, "Ejection fraction ": 15.696630541394146, "Electrocardiogram QT prolonged ": 2.201830748755588, "Eosinophilia ": 3.7998942047229662, "Erdheim-Chester disease ": 3599.1438851289136, "Eye haemorrhage ": 2.770930800760256, "FEV1/FVC ratio abnormal ": 464.32046200070266, "Facial paralysis ": 4.414511469384312, "Feeling of body temperature change ": 2.530023739496978, "Fibromyalgia ": 2.508346861358289, "Flatulence ": 2.144860094268031, "Forced expiratory volume abnormal ": 153.74561439498896, "Frequent bowel movements ": 2.0136444136330525, "Fungal infection ": 3.241946779004328, "Gamma-glutamyltransferase increased ": 2.4268568895820968, "Gastrooesophageal reflux disease ": 2.660388133778673, "Haematocrit decreased ": 2.2959368742897643, "Haemoglobin decreased ": 2.065888897318612, "Haemolytic anaemia ": 2.864394408483126, "Heart rate decreased ": 2.1067836539002034, "Hemiplegia ": 15.051830953169755, "Hepatic cytolysis ": 5.936194455305411, "Hepatitis cholestatic ": 5.1740598082943725, "Hepatocellular injury ": 4.238009404699844, "Hip fracture ": 2.195249154858371, "Hydronephrosis ": 22.722424141571256, "Hyperkalaemia ": 3.05422954871171, "Hypocalcaemia ": 4.315871481939196, "Hypomagnesaemia ": 11.301567551637548, "Hyponatraemia ": 6.1934911328850415, "Inappropriate antidiuretic hormone secretion ": 4.68695369620357, "Incorrect product administration duration ": 2.3999916659435976, "Increased appetite ": 2.501307115515281, "Injection site extravasation ": 8.281916500075894, "Intentional overdose ": 12.269213907308025, "Intervertebral disc disorder ": 12.922795790440302, "Iron deficiency ": 64.45286160110963, "Ischaemic stroke ": 6.762726789423836, "Lactic acidosis ": 4.460404056707669, "Lymphoedema ": 4.770843793537126, "Lymphoma ": 3.873476774973775, "Major depression ": 101.11756952010852, "Malnutrition ": 6.876028483988614, "Metabolic acidosis ": 47.04828479884403, "Motor dysfunction ": 4.934519683934377, "Multi-organ disorder ": 26.712879623594432, "Multiple organ dysfunction syndrome ": 2.3906239330462835, "Muscle atrophy ": 4.087823959316461, "Muscle spasticity ": 6.060979420579608, "Neuroleptic malignant syndrome ": 11.86522508139484, "Normal newborn ": 8.50720724557446, "Obstructive airways disorder ": 2.097997070885026, "Oesophagitis ": 5.102870786981723, "Oral lichen planus ": 56.02847417416725, "Pancreatitis acute ": 7.175900814347076, "Papillary thyroid cancer ": 59.179539972509694, "Patent ductus arteriosus ": 11.78958046933987, "Pericardial effusion ": 2.5573390850603825, "Personality disorder ": 16.45643956581091, "Photopsia ": 4.334321809544095, "Physical deconditioning ": 152.45535552702785, "Pleural effusion ": 3.36544633749827, "Polycystic ovaries ": 28.03127236743863, "Portal vein thrombosis ": 6.199317682575309, "Premature baby ": 2.491312112019289, "Protein total decreased ": 8.992006964143311, "Pseudodementia ": 215.6324427323596, "Pulmonary hypertension ": 2.539047318102392, "Rash maculo-papular ": 3.4752048904599184, "Respiratory distress ": 4.006151180557453, "Respiratory failure ": 2.267793047291853, "Rhabdomyolysis ": 7.04782341843211, "Rhinitis allergic ": 5.4439130683398655, "Sedation ": 4.098304803508921, "Sensitisation ": 16.793746205359273, "Serotonin syndrome ": 34.30555816168346, "Skin ulcer ": 16.85275523465684, "Sleep apnoea syndrome ": 4.18688484368344, "Sleep disorder due to a general medical condition ": 2.448396840811888, "Sudden death ": 2.201333354742532, "Suicide attempt ": 12.107441516949448, "Tenosynovitis ": 9.150863003963302, "Therapeutic product effect incomplete ": 2.499211104418301, "Thyroid disorder ": 3.087644340943386, "Toxic epidermal necrolysis ": 3.1705875715707443, "Toxicity to various agents ": 3.2299977469305428, "Tubulointerstitial nephritis ": 10.229963824484969, "Unresponsive to stimuli ": 2.403354240811701, "Vitamin B12 deficiency ": 11.927802543359984} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/434.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/434.json new file mode 100644 index 00000000000..26dbf408656 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/434.json @@ -0,0 +1 @@ +{"Ankylosing spondylitis ": 17.687758158197074, "Arthritis ": 2.194497127806509, "Bronchitis ": 3.1556564677496084, "Condition aggravated ": 2.862439595385037, "Drug ineffective ": 5.44452129121055, "Drug ineffective for unapproved indication ": 8.014931198548112, "Drug intolerance ": 3.074957687058699, "Drug specific antibody ": 118.6208654256426, "Dry eye ": 11.645524700313649, "Fibrosis ": 46.537228323332975, "Gait inability ": 6.314367742740171, "Gastric haemorrhage ": 14.295689138236703, "Gastrointestinal disorder ": 2.758593164817002, "Ill-defined disorder ": 4.136068713236246, "Inflammation ": 8.211937068420342, "Infusion related reaction ": 2.755980402086721, "Joint swelling ": 6.734660466452948, "Lower respiratory tract infection ": 7.993038953770923, "Metabolic surgery ": 135.73418500554973, "Mobility decreased ": 3.1574895531528955, "Mouth ulceration ": 5.967306600523477, "Musculoskeletal stiffness ": 4.673732889500736, "Pancytopenia ": 3.1591460241836087, "Pharyngitis ": 23.03344890703354, "Product use in unapproved indication ": 2.035284267643749, "Psoriatic arthropathy ": 5.280557119405412, "Renal cyst ": 16.668164453284717, "Rheumatoid arthritis ": 5.631322626424913, "Sleep apnoea syndrome ": 15.490376288416511, "Synovitis ": 7.351519167574231, "Therapeutic product effect decreased ": 4.728010150576854, "Therapeutic product effect incomplete ": 2.193100388495488, "Toothache ": 20.25336712824321, "Treatment failure ": 5.132143088343799, "Urinary tract infection ": 2.926756893845459, "Vasculitis ": 6.094589287386944, "Vitiligo ": 46.50624058279444} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/435.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/435.json new file mode 100644 index 00000000000..fa44cd9b02f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/435.json @@ -0,0 +1 @@ +{"Anaemia ": 6.528893855488719, "Thrombocytopenia ": 5.687978020880372} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/436.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/436.json new file mode 100644 index 00000000000..c72186f1bc7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/436.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.796479139298581, "Abdominal pain upper ": 3.803817952370124, "Acute kidney injury ": 5.737531314237847, "Alanine aminotransferase increased ": 2.839805805747653, "Amylase increased ": 29.46604981944361, "Angioedema ": 4.353967507455475, "Anuria ": 7.084855627102629, "Blister ": 5.564323440104054, "Blood glucose abnormal ": 4.7680095273092045, "Blood glucose increased ": 3.7479470361611016, "Cholestasis ": 2.4232999562892514, "Chromaturia ": 4.015750077957812, "Coma ": 2.111216858542408, "Dermatitis bullous ": 24.383506259140844, "Diabetes mellitus inadequate control ": 6.844122069330457, "Diarrhoea ": 2.153592239024237, "Dysphagia ": 2.4359430013814727, "Eczema ": 3.4967921072958306, "Eosinophilia ": 3.235380510740385, "Flatulence ": 4.133856811584389, "Gamma-glutamyltransferase increased ": 8.70891737749009, "Glycosylated haemoglobin increased ": 20.25568493182673, "Hepatic cytolysis ": 3.6749664536199433, "Hepatic steatosis ": 5.053654039446934, "Hepatitis ": 3.5073875534566032, "Hyperglycaemia ": 3.517447406920152, "Hyperkalaemia ": 10.712512431115888, "Hypoglycaemia ": 7.1271169551344205, "Hypothermia ": 7.131139310790509, "Jaundice ": 4.055669878212297, "Lactic acidosis ": 54.0076132996157, "Lipase increased ": 67.63168697118317, "Metabolic acidosis ": 12.854079728363898, "Oedema peripheral ": 2.233242635202733, "Pancreatic carcinoma ": 25.51502488151719, "Pancreatic carcinoma metastatic ": 13.566853639311631, "Pancreatitis ": 12.53858841408445, "Pancreatitis acute ": 23.31092100895109, "Pemphigoid ": 101.41832654564612, "Pemphigus ": 2.385749495898354, "Pruritus ": 2.62907971593626, "Scratch ": 14.68221026310497, "Shock ": 3.8966614155691, "Skin exfoliation ": 3.014405639842455, "Tachypnoea ": 3.4290015117298958, "Transaminases increased ": 7.1391336025862735, "Weight decreased ": 3.4346742377569863} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/437.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/437.json new file mode 100644 index 00000000000..979bfe6ffeb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/437.json @@ -0,0 +1 @@ +{"Toxic epidermal necrolysis ": 1310.0945573625113} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/438.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/438.json new file mode 100644 index 00000000000..288cefdb719 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/438.json @@ -0,0 +1 @@ +{"Accident ": 5.144035107094759, "Acute myocardial infarction ": 7.325563270362159, "Angina pectoris ": 5.096299573872878, "Aortic dissection ": 43.391853880427526, "Arrhythmia ": 2.9160239852004186, "Atrial fibrillation ": 2.734237611659318, "Atypical femur fracture ": 213.41435445724005, "Atypical fracture ": 224.31030932772043, "Blood alkaline phosphatase increased ": 2.774168954891828, "Blood calcium decreased ": 13.234423592449104, "Blood calcium increased ": 8.554528081514452, "Blood parathyroid hormone increased ": 36.13298525304862, "Bone density abnormal ": 84.08274061974352, "Bone disorder ": 3.775575725507248, "Bone pain ": 3.3556331403174613, "Cardiac failure ": 8.142897428970938, "Cardiac failure acute ": 3.824127992436815, "Cardiac valve disease ": 6.364659014219273, "Cerebellar haemorrhage ": 9.53038046414173, "Cerebral haemorrhage ": 6.3443704720361405, "Cerebral infarction ": 37.763819754613, "Cerebrovascular accident ": 3.477571262860085, "Colon cancer ": 3.350564067893551, "Compression fracture ": 111.38521889177213, "Dementia ": 6.38362169263948, "Device issue ": 2.773834576914907, "Drug effect less than expected ": 11.829188906857402, "Fall ": 12.933825815671687, "Femoral neck fracture ": 109.3183785369566, "Femur fracture ": 55.55938056204546, "Foot fracture ": 3.732413956682307, "Fracture ": 110.43387424951868, "Groin pain ": 6.792578362636017, "Haemorrhagic stroke ": 3.578442986039483, "Hip fracture ": 11.528819794365058, "Humerus fracture ": 33.35886865017544, "Hypercalcaemia ": 8.224792986348008, "Hypocalcaemia ": 20.622950207417933, "Ill-defined disorder ": 6.089371274751175, "Incorrect dose administered ": 4.0870254340427525, "Injection site bruising ": 3.1019959216213184, "Injection site erythema ": 2.879290018259928, "Injection site mass ": 4.571729353193205, "Injection site swelling ": 2.986074547492431, "Intentional dose omission ": 6.336179286098685, "Intracranial aneurysm ": 11.291548026712093, "Ischaemic cerebral infarction ": 22.582858916587057, "Ischaemic stroke ": 2.5693306780159952, "Lacunar infarction ": 33.699373431212905, "Loose tooth ": 17.923837666594252, "Lower limb fracture ": 3.490797371104312, "Lumbar vertebral fracture ": 76.62288260096102, "Lung neoplasm malignant ": 2.529412716010654, "Lymphoma ": 2.698702429827353, "Marasmus ": 87.59384467418964, "Myocardial infarction ": 5.414172495557952, "Osteomyelitis ": 5.840069245667778, "Osteonecrosis of jaw ": 79.22637126581128, "Pain in jaw ": 3.2613983174053947, "Parkinson's disease ": 2.926948208048838, "Pathological fracture ": 48.53169007781396, "Pelvic fracture ": 26.831616776128005, "Physical deconditioning ": 15.201333457368364, "Pneumonia aspiration ": 5.000132700453898, "Polymyalgia rheumatica ": 3.645073409048223, "Product administration interrupted ": 30.2334681074962, "Pseudarthrosis ": 261.59813408667446, "Radius fracture ": 101.206244799868, "Renal impairment ": 4.384872013152113, "Rib fracture ": 5.490175872880482, "Spinal compression fracture ": 98.82642522688928, "Spinal disorder ": 7.167093533958791, "Spinal fracture ": 70.15579788005445, "Spinal operation ": 9.317071321301713, "Stress fracture ": 17.55122792646365, "Subarachnoid haemorrhage ": 7.950975202226571, "Subdural haematoma ": 3.341747108730501, "Sudden death ": 4.108090162567711, "Surgery ": 3.5739627670567877, "Thalamus haemorrhage ": 16.490124475169907, "Therapy interrupted ": 6.469732792247984, "Thoracic vertebral fracture ": 118.69884794778946, "Tibia fracture ": 9.020705761638062, "Tooth disorder ": 6.273600837694171, "Tooth extraction ": 17.492160552502018, "Tooth infection ": 6.41678709579727, "Transient ischaemic attack ": 8.15057614678674, "Unevaluable event ": 7.291176011995714, "Upper limb fracture ": 7.887001755859747, "Wrist fracture ": 11.054667842951089} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/439.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/439.json new file mode 100644 index 00000000000..c842d0ac60b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/439.json @@ -0,0 +1 @@ +{"Ascites ": 2.765764743568304, "Blood alkaline phosphatase increased ": 2.077306977926209, "Blood lactate dehydrogenase increased ": 3.642831200084728, "Blood magnesium decreased ": 13.762875400735172, "Blood phosphorus decreased ": 20.200027659713385, "Blood pressure systolic increased ": 4.777221955175985, "Blood thyroid stimulating hormone increased ": 7.878227121765229, "Blood triglycerides increased ": 7.099972640559061, "Blood urea increased ": 4.669591411647087, "Body temperature decreased ": 5.794183636533713, "Bone pain ": 4.131972932645251, "Breast cancer ": 3.393652508877239, "Breast cancer metastatic ": 39.16397170009321, "Cardiac neoplasm malignant ": 1370.9472851697726, "Cytomegalovirus infection ": 14.298008998173785, "Diabetes mellitus ": 2.82404467931253, "Disease progression ": 5.371173345611446, "Drug interaction ": 2.2737607901536254, "Drug intolerance ": 3.5339743276471687, "Drug level increased ": 2.9005944344684376, "Drug resistance ": 5.273792086447853, "Electrocardiogram ST segment elevation ": 24.214403426721475, "Electrolyte imbalance ": 6.312003765456354, "Eyelid oedema ": 3.2907684808401663, "Gastric haemorrhage ": 5.885428147723778, "Gastric ulcer ": 3.605499057521736, "General physical health deterioration ": 2.265481252832702, "Haematemesis ": 2.177070177769392, "Haemoglobin decreased ": 2.107842887709875, "Haemoptysis ": 2.70950515316095, "Hepatic lesion ": 13.903296751737496, "Hepatic mass ": 29.730763792722183, "Hormone receptor positive breast cancer ": 257.72149654337187, "Hypothyroidism ": 3.953510726380879, "Hypoxia ": 3.7770093858823537, "Immunosuppressant drug level increased ": 27.509769063503462, "Infantile spasms ": 117.93038841103424, "Ingrowing nail ": 55.71051236674529, "Interstitial lung disease ": 3.2609879601867244, "Leukopenia ": 2.981597718104191, "Lung disorder ": 2.732633687773769, "Lung infiltration ": 13.40256776412486, "Malignant neoplasm progression ": 24.097942047331514, "Malignant pleural effusion ": 45.353502992322944, "Metastases to bone ": 44.916092013069736, "Metastases to central nervous system ": 5.909263629848896, "Metastases to kidney ": 201.56682743457355, "Metastases to liver ": 49.40117682104076, "Metastases to lung ": 41.68066664429985, "Metastases to lymph nodes ": 24.873221042092617, "Metastases to skin ": 93.9978510593902, "Metastases to spine ": 24.43880980660968, "Metastasis ": 12.058787052567316, "Metastatic renal cell carcinoma ": 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end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/446.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/446.json new file mode 100644 index 00000000000..9162c98cbf3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/446.json @@ -0,0 +1 @@ +{"Hyperkalaemia ": 35.18193331870564, "Off label use ": 3.240885837103567, "Product use issue ": 13.896638095810998, "Sepsis ": 14.29925800453056} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/447.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/447.json new file mode 100644 index 00000000000..1d5d16066bc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/447.json @@ -0,0 +1 @@ +{"Anaphylactic reaction ": 2.8118731507226715, "Blood pressure increased ": 2.09635426668533, "COVID-19 ": 10.8807155937457, "COVID-19 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newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/45.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/45.json new file mode 100644 index 00000000000..3c8fa641cb1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/45.json @@ -0,0 +1 @@ +{"Constipation ": 8.640128677945562, "Drug interaction ": 5.997742681229084, "Interstitial lung disease ": 19.73846127964552} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/450.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/450.json new file mode 100644 index 00000000000..3c1f2a5c0b0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/450.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 9.28166861438496, "Decreased appetite ": 3.4396751949980957, "Weight decreased ": 5.429548847765617} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/451.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/451.json new file mode 100644 index 00000000000..bb098692001 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/451.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.3754092024919373, "Angina pectoris ": 2.862233653237765, "Angioedema ": 2.980556821838915, "Anuria ": 2.5336996573190254, "Aortic aneurysm ": 6.873072114304232, "Aortic arteriosclerosis ": 5.060357905848247, "Aortic valve incompetence ": 4.628532070591958, "Arrhythmia ": 3.1963046096998564, "Arterial occlusive disease ": 5.835231522706204, "Asphyxia ": 4.232353464507827, "Bladder cancer ": 2.209249633112308, "Bladder disorder ": 2.28905656664189, "Blood albumin decreased ": 2.9870501055939824, "Blood creatinine increased ": 2.7584972517523774, "Blood disorder ": 2.2341301141439827, "Blood potassium decreased ": 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3.9922118844832912, "Product colour issue ": 6.306453795668079, "Product packaging issue ": 5.314014646248573, "Product prescribing error ": 4.134033899364286, "Product residue present ": 2.287583403744086, "Raynaud's phenomenon ": 2.516973718853111, "Red blood cell sedimentation rate increased ": 2.223274593071863, "Renal artery stenosis ": 8.552600639720499, "Renal disorder ": 3.3375732780894536, "Sinus node dysfunction ": 4.278199541453614, "Skin cancer ": 2.187589551048494, "Spinal disorder ": 2.7850237261793627, "Swelling face ": 2.593728764268929, "Thyroid cancer ": 2.604958340625363, "Tibia fracture ": 3.923154031353697, "Type 2 diabetes mellitus ": 3.255823184513652, "Ulcer ": 2.2234445772559046, "Upper limb fracture ": 2.4993057898153523, "Vein disorder ": 4.123850184264754, "Ventricular extrasystoles ": 2.04097172482194, "Wrist fracture ": 2.537606806803676, "Wrong technique in product usage process ": 11.309267465121987} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/452.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/452.json new file mode 100644 index 00000000000..3c07f6981eb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/452.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.024984914461906, "Abdominal pain ": 2.135090031256191, "Abdominal tenderness ": 4.693681446594666, "Acidosis ": 2.1980557711728936, "Activated partial thromboplastin time prolonged ": 3.5273290095828997, "Acute chest syndrome ": 92.08825314053009, "Acute hepatic failure ": 2.6364694038824537, "Acute leukaemia ": 49.21185453598088, "Acute myeloid leukaemia ": 18.52721990152359, "Acute myeloid leukaemia recurrent ": 3.18253852827501, "Alanine aminotransferase increased ": 6.005797331883106, "Ammonia increased ": 4.95919371310263, "Anuria ": 2.342633833001168, "Aortic stenosis ": 3.64016087415864, "Aplastic anaemia ": 8.908519567182362, "Aspartate aminotransferase increased ": 5.962000952914598, "Atelectasis ": 2.6752595943509974, "Auditory disorder ": 6.109512861854927, "Azotaemia ": 3.514590358387216, "Bacteraemia ": 3.442766723837226, "Bacterial infection ": 2.610407809077524, "Bilirubin conjugated increased ": 8.415419366528496, "Blast cell count increased ": 8.574264750041122, "Blood albumin decreased ": 10.034358852646903, "Blood alkaline phosphatase increased ": 5.117297254549858, "Blood bicarbonate decreased ": 5.665182473005377, "Blood bilirubin increased ": 8.492450775917291, "Blood bilirubin unconjugated increased ": 6.156810747961655, "Blood calcium decreased ": 6.663526877428926, "Blood chloride decreased ": 6.042427153229768, "Blood chloride increased ": 13.48837494653984, "Blood creatine increased ": 2.4061117849041787, "Blood creatinine abnormal ": 5.858515577669999, "Blood creatinine decreased ": 7.373393112307101, "Blood creatinine increased ": 10.89301595912391, "Blood culture positive ": 5.538900191804967, "Blood disorder ": 2.46488971672355, "Blood iron increased ": 119.8258186310886, "Blood lactate dehydrogenase increased ": 4.1037315986560206, "Blood phosphorus decreased ": 5.782874285663376, "Blood potassium decreased ": 2.671426085233832, "Blood potassium increased ": 3.0961584268525693, "Blood pressure diastolic decreased ": 5.634849481211608, "Blood sodium decreased ": 3.4005929509187056, "Blood sodium increased ": 6.069592874776522, "Blood urea decreased ": 5.791122947023763, "Blood urea increased ": 15.412722482895717, "Blood urine present ": 2.799774651437241, "Bone marrow disorder ": 15.083305244680997, "Bone marrow failure ": 4.626901518625361, "Bone marrow transplant ": 109.04897613639268, "Brain natriuretic peptide increased ": 2.286815481654695, "Breath sounds abnormal ": 3.128864064825811, "Carbon dioxide decreased ": 8.212779660713503, "Cardiac failure congestive ": 2.621776447393862, "Cardiac murmur ": 3.606484747885607, "Cardiomegaly ": 2.5713692830985493, "Central venous catheterisation ": 4.467796382445273, "Cholecystectomy ": 4.240231982325946, "Cholecystitis ": 2.362144882383937, "Cholelithiasis ": 4.806846350703177, "Chromaturia ": 4.765211081937268, "Chronic lymphocytic leukaemia ": 5.5681860657286135, "Complications of bone marrow transplant ": 32.829084814980405, "Concomitant disease aggravated ": 2.2500085031681465, "Concomitant disease progression ": 12.400106385308838, "Creatinine renal clearance decreased ": 9.994502285767645, "Deafness ": 4.731883978338439, "Deafness bilateral ": 4.165618786056417, "Deafness neurosensory ": 2.751221742200725, "Deafness unilateral ": 2.863145960057348, "Death ": 10.018908185658946, "Dehydration ": 2.5933876072644275, "Device related infection ": 4.365029135129989, "Dialysis ": 6.654257335853846, "Diarrhoea ": 2.7402876817734425, "Disease progression ": 3.1534446157782527, "Duodenal ulcer ": 5.436534657061409, "Duodenal ulcer haemorrhage ": 3.8422594154079657, "Endotracheal 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"Haemosiderosis ": 93.84489672779354, "Hepatic cirrhosis ": 2.352722657010078, "Hepatic enzyme increased ": 3.1724211683051777, "Hepatic failure ": 4.514250262162161, "Hepatic fibrosis ": 4.473366987393571, "Hepatomegaly ": 4.8437052723761695, "Hip fracture ": 3.2707006407485224, "Hip surgery ": 2.9352915188951987, "Hyperammonaemia ": 2.4277984382224638, "Hyperbilirubinaemia ": 3.5911029552396547, "Hypersplenism ": 16.70671098723399, "Hypertransaminasaemia ": 2.778442021269, "Hypervolaemia ": 3.036101144071559, "Hypoacusis ": 6.995223103479724, "Hypophagia ": 3.079688626183204, "Hypophosphataemia ": 5.706767815221547, "Infection ": 3.6702916949729456, "Iron overload ": 144.148417187257, "Jaundice ": 3.448022727741748, "Leukaemia ": 14.559671672923406, "Leukaemia recurrent ": 4.742938287362217, "Leukocytosis ": 4.307885996779434, "Liver disorder ": 4.537421315914231, "Liver function test abnormal ": 2.604317477218185, "Liver function test increased ": 6.715562055717308, "Lung infiltration ": 4.858509247715617, "Maculopathy ": 4.332810753745315, "Malignant neoplasm progression ": 4.078279143019933, "Marrow hyperplasia ": 13.520492208506973, "Mean cell volume increased ": 9.63950830565918, "Mental status changes ": 3.559153564554105, "Metabolic acidosis ": 4.195162887286397, "Monocyte count increased ": 5.627645872578109, "Mucormycosis ": 5.850057172938651, "Multiple organ dysfunction syndrome ": 2.6130449156549465, "Myelodysplastic syndrome ": 33.35937060389989, "Myelodysplastic syndrome transformation ": 477.023938774888, "Myelofibrosis ": 18.718076744532823, "Neoplasm progression ": 2.3131460758941658, "Nephrolithiasis ": 2.822571011053649, "Neutrophil count increased ": 3.251296950215474, "Occult blood positive ": 4.245833867728391, "Ocular icterus ": 4.793531916887997, "Orthopnoea ": 2.42879212732862, "Pancytopenia ": 2.938076015301399, "Peptic ulcer ": 3.2601980597325584, "Platelet count decreased ": 3.57647195048061, "Platelet count increased ": 4.981653757931294, "Pneumonia ": 2.730508652495221, "Post procedural complication ": 2.508990298476559, "Protein total decreased ": 14.599246450086667, "Protein total increased ": 5.443680301476359, "Protein urine present ": 4.064352527770911, "Proteinuria ": 5.915398565375088, "Pulmonary hypertension ": 2.266171219091458, "Rales ": 2.675232185901105, "Red blood cell count decreased ": 5.257653590865671, "Red cell distribution width increased ": 13.174959563335372, "Renal colic ": 2.2673169375475566, "Renal cyst ": 2.340320063791559, "Renal disorder ": 8.50468473112307, "Renal failure ": 2.904039509973888, "Renal function test abnormal ": 10.870881320319434, "Renal impairment ": 3.516518196953614, "Renal tubular acidosis ": 14.132654913896944, "Renal tubular disorder ": 11.188366386069177, "Renal tubular dysfunction ": 5.08523625607752, "Renal tubular necrosis ": 3.0605772355299328, "Reticulocyte count increased ": 23.22915423843535, "Sepsis ": 4.4121115161537885, "Septic shock ": 2.3982310973700933, "Serum ferritin abnormal ": 172.005066865985, "Serum ferritin decreased ": 19.863293033834637, "Serum ferritin increased ": 199.9848377044482, "Sickle cell anaemia ": 60.007410891245776, "Sickle cell anaemia with crisis ": 1974.8523594569065, "Sickle cell disease ": 295.2599808711, "Spleen disorder ": 7.493857235430455, "Splenectomy ": 15.402495212187567, "Splenomegaly ": 10.18890036612246, "Staphylococcal infection ": 3.2893348568598206, "Stem cell transplant ": 52.6131199819559, "Terminal state ": 8.640217524012392, "Thrombocytosis ": 3.0095814861494827, "Transaminases increased ": 4.696380788409898, "Transfusion reaction ": 17.444916406238743, "Transplant ": 41.05791453028094, "Treatment noncompliance ": 3.1948857889591986, "Ulcer ": 3.0102400110794845, "Urinary tract infection ": 2.1815568398810745, "Urine analysis abnormal ": 3.849751641714897, "Urine output decreased ": 8.527765378255916, "Urine protein/creatinine ratio increased ": 17.29961655292397, "Venoocclusive disease ": 3.823129080982479, "Viral infection ": 2.1822166174237823, "White blood cell count increased ": 6.888005128195317, "Wound infection ": 2.223586435813285} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/453.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/453.json new file mode 100644 index 00000000000..b1a7a9b5de1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/453.json @@ -0,0 +1 @@ +{"Blood glucose increased ": 19.75753765638221, "Chest pain ": 3.815785153627956, "Cough ": 5.442992658547183, "Dyspnoea ": 4.677086347492649, "Hyperglycaemia ": 12.53631536929412, "Hypoglycaemia ": 7.456201877066892} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/454.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/454.json new file mode 100644 index 00000000000..2c08eae50a5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/454.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 12.357646321432814, "Alanine aminotransferase increased ": 5.204419829443654, "Anaemia ": 6.348208513294857, "Ascites ": 38.64683858815975, "Aspartate aminotransferase increased ": 2.1070799263250666, "Asthenia ": 3.371180900629952, "Bilirubin conjugated increased ": 19.84365712763798, "Blood bilirubin increased ": 35.93051297311714, "Cardiac failure ": 2.2370518557048134, "Cardio-respiratory arrest ": 2.293777440128724, "Child-Pugh-Turcotte score increased ": 502.17815484810274, "Cholelithiasis ": 2.8851364449251573, "Chromaturia ": 3.0008808850100834, "Coagulopathy ": 4.279825938909228, "Dyspepsia ": 2.8344906864074657, "Encephalopathy ": 10.850321978614751, "Fibrosis ": 27.12601783360264, "General physical health deterioration ": 2.136884402892667, "Haematemesis ": 2.2427581704836985, "Haemoglobin decreased ": 2.635605868865448, "Haemolysis ": 6.469178084977756, "Hepatic cirrhosis ": 34.06868530255819, "Hepatic cytolysis ": 2.193932514797939, "Hepatic encephalopathy ": 45.286269277756666, "Hepatic failure ": 28.82156358633786, "Hepatic lesion ": 14.322785173136614, "Hepatitis C ": 8.994358041029216, "Hepatocellular carcinoma ": 23.950892692541142, "Hepatorenal syndrome ": 58.33212065210742, "Hyperbilirubinaemia ": 72.20944292212168, "Hyperkalaemia ": 2.613354738259977, "Hypertransaminasaemia ": 9.198437606846044, "Hyponatraemia ": 2.4919166937483785, "International normalised ratio increased ": 2.911021979853384, "Jaundice ": 27.597928530877887, "Leukocytosis ": 4.379126736334502, "Metabolic acidosis ": 2.8869399621863963, "Ocular icterus ": 14.675267961757802, "Oedema ": 2.3626370500136225, "Oedema peripheral ": 3.715158297096089, "Oesophageal varices haemorrhage ": 23.090356520143576, "Portal vein thrombosis ": 18.7773343372558, "Pruritus ": 3.196564920252836, "Renal failure ": 2.0668441056368168, "Splenomegaly ": 5.306851448982666, "Toxic skin eruption ": 3.302812569092926, "Transaminases increased ": 4.711716968982541, "Yellow skin ": 23.521585810174944} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/455.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/455.json new file mode 100644 index 00000000000..0995ed4329f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/455.json @@ -0,0 +1 @@ +{"Abnormal sensation in eye ": 15.953108738421426, "Acute myocardial infarction ": 2.978288707545049, "Age-related macular degeneration ": 97.09030381125112, "Amaurosis ": 24.41685404279485, "Amaurosis fugax ": 45.614817599800816, "Angle closure glaucoma ": 5.0115993190249695, "Anterior chamber cell ": 220.42130832410268, "Anterior chamber disorder ": 257.3020836062199, "Anterior chamber fibrin ": 92.54339094341348, "Anterior chamber flare ": 113.57051882361128, "Anterior chamber inflammation ": 218.07082240954225, "Bacterial endophthalmitis ": 485.90432951033193, "Blepharitis ": 7.002434719385906, "Blindness ": 43.81685030614845, "Blindness transient ": 252.2157695337441, "Blindness unilateral ": 144.42827962924525, "Brain stem infarction ": 9.13342428930855, "Carotid artery stenosis ": 4.320024118545673, "Cataract ": 11.084338251543995, "Cataract operation ": 33.26683624145024, "Cataract subcapsular ": 27.34508598377765, "Cerebellar infarction ": 7.5041412208292195, "Cerebral infarction ": 20.016398461059826, "Cerebrovascular accident ": 4.654098604584848, "Chorioretinitis ": 36.39259936955911, "Choroidal detachment ": 35.59455948346369, "Choroidal neovascularisation ": 137.8067419704543, "Ciliary hyperaemia ": 159.1014628659436, "Conjunctival haemorrhage ": 21.510055283823213, "Conjunctival hyperaemia ": 8.680281110325517, "Conjunctivitis ": 2.224855414779106, "Corneal abrasion ": 79.22424473327833, "Corneal deposits ": 17.64320088758087, "Corneal disorder ": 27.68423639252491, "Corneal epithelium defect ": 29.88706782430245, "Corneal oedema ": 86.31563507370522, "Corneal opacity ": 22.833123397192978, "Cystoid macular oedema ": 22.44112680198683, "Death ": 2.204107918844982, "Dementia ": 2.505447124480729, "Detachment of retinal pigment epithelium ": 372.9459482733552, "Device difficult to use ": 6.087893877864897, "Device use issue ": 217.316309397297, "Diabetic retinal oedema ": 124.92492918291546, "Diabetic retinopathy ": 3.0100254670406428, "Dry age-related macular degeneration ": 122.15658948436617, "Dry eye ": 3.499624143108395, "Dyslalia ": 12.040002848317735, "Endophthalmitis ": 1942.745293787745, "Epiretinal membrane ": 33.33842575754128, "Eye discharge ": 13.289215087438189, "Eye disorder ": 9.147191615736746, "Eye haemorrhage ": 32.4093703467766, "Eye infection ": 39.06543684664333, "Eye infection bacterial ": 129.1118201597616, "Eye infection intraocular ": 87.94672136434488, "Eye infection staphylococcal ": 454.60348197958166, "Eye inflammation ": 254.6131071060545, "Eye injury ": 8.227117728212026, "Eye irritation ": 10.467813731777854, "Eye oedema ": 13.80709139753885, "Eye operation ": 8.098176816648339, "Eye pain ": 28.59637096345653, "Eye swelling ": 3.959579593691514, "Foreign body in eye ": 88.51253366194975, "Foreign body sensation in eyes ": 43.33124274476269, "Glaucoma ": 5.143838253255844, "Haemorrhagic stroke ": 2.5175891256387826, "Hemiparesis ": 2.189787587209978, "Hemiplegia ": 6.7019038531215225, "Hyphaema ": 42.69452236190926, "Hypopyon ": 480.1282698382223, "Hypotony of eye ": 193.76085333873388, "Inadequate aseptic technique in use of product ": 687.0395364038268, "Inappropriate schedule of product administration ": 2.0418929123166327, "Injection site discomfort ": 5.255075021735088, "Injection site haemorrhage ": 4.887088088928733, "Intentional dose omission ": 2.999944850978076, "Intra-ocular injection complication ": 1404.1588835979603, "Intraocular pressure decreased ": 302.121786975536, "Intraocular pressure increased ": 193.96833077091864, "Iridocyclitis ": 79.61471160622825, "Iritis ": 110.45533537298576, "Ischaemic stroke ": 5.0471871161541735, "Keratic precipitates ": 115.21060924115991, "Keratitis ": 11.272315394999668, "Lacrimation increased ": 8.312456745513204, "Lacunar infarction ": 10.415320143467117, "Macular degeneration ": 6.596083476724825, "Macular fibrosis ": 251.2185392333289, "Macular hole ": 133.99738726450923, "Macular oedema ": 43.9068730243313, "Maculopathy ": 14.33417113903644, "Metamorphopsia ": 74.88310403194838, "Multiple use of single-use product ": 391.0920808504305, "Myocardial infarction ": 2.8229705505699805, "Neovascular age-related macular degeneration ": 129.7050682507325, "Non-infectious endophthalmitis ": 5223.992318143326, "Ocular discomfort ": 11.369010583106714, "Ocular hyperaemia ": 16.473275989170876, "Ocular hypertension ": 86.21309615490061, "Ocular procedural complication ": 610.6207487368232, "Ocular vasculitis ": 90.79550693576324, "Photophobia ": 6.238307229204585, "Photopsia ": 9.575116758061895, "Polypoidal choroidal vasculopathy ": 1001.2685046105308, "Posterior capsule opacification ": 67.87894724426535, "Product contamination ": 11.976672147455483, "Product dose omission issue ": 2.623112914533888, "Product prescribing issue ": 3.486657940211172, "Pseudoendophthalmitis ": 1820.0005019124112, "Refusal of treatment by patient ": 13.90272595391154, "Retinal artery occlusion ": 93.34376209234352, "Retinal degeneration ": 65.44171815933119, "Retinal detachment ": 26.495385864554127, "Retinal disorder ": 15.356751614827449, "Retinal exudates ": 24.19964606286488, "Retinal haemorrhage ": 76.53477427877937, "Retinal ischaemia ": 23.23073394851843, "Retinal neovascularisation ": 130.09748721286016, "Retinal oedema ": 120.55891837390185, "Retinal pigment epithelial tear ": 2407.272277697576, "Retinal pigment epitheliopathy ": 57.26161976336248, "Retinal scar ": 140.04274260126832, "Retinal tear ": 36.77799147822549, "Retinal thickening ": 334.74645262170145, "Retinal vascular disorder ": 29.07732837897866, "Retinal vascular occlusion ": 25.03470553304416, "Retinal vasculitis ": 39.34633060336998, "Retinal vein occlusion ": 13.165534798078466, "Scleritis ": 14.617897733175546, "Serous retinal detachment ": 44.76182689470113, "Staphylococcus test positive ": 13.1720995027904, "Streptococcal infection ": 7.1067944322582095, "Subretinal fluid ": 264.2845267900933, "Sudden visual loss ": 60.4421654417824, "Suspected product quality issue ": 19.89185554968532, "Swelling of eyelid ": 4.114859367495336, "Syringe issue ": 28.849546223776585, "Therapeutic product ineffective ": 4.799985466043739, "Thrombotic cerebral infarction ": 36.69699436613178, "Toxic anterior segment syndrome ": 29.81871117223606, "Transient ischaemic attack ": 7.290471782483634, "Ulcerative keratitis ": 7.643840467955442, "Uveitis ": 98.5074723354702, "Vision blurred ": 12.0628530028303, "Visual acuity reduced ": 106.82419652228845, "Visual acuity reduced transiently ": 205.06829786600085, "Visual field defect ": 9.664499307605578, "Visual impairment ": 15.071782429343443, "Vitreal cells ": 605.7617790476562, "Vitrectomy ": 2302.320212729981, "Vitreous detachment ": 28.306901436128783, "Vitreous disorder ": 187.1509105713562, "Vitreous floaters ": 98.6555427228078, "Vitreous haemorrhage ": 104.27708349515328, "Vitreous opacities ": 296.5778188337842, "Vitritis ": 341.3858393719946, "Wrong technique in product usage process ": 6.9293358692259455} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/456.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/456.json new file mode 100644 index 00000000000..1be8c42352e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/456.json @@ -0,0 +1 @@ +{"Confusional state ": 4.7280342313327886} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/457.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/457.json new file mode 100644 index 00000000000..3d3e0dad443 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/457.json @@ -0,0 +1 @@ +{"Balance disorder ": 17.061613810611448, "Condition aggravated ": 2.717601902745883, "Constipation ": 2.2648720019344477, "Dysstasia ": 7.656753256853584, "Encephalopathy ": 6.542838570896499, "Excessive granulation tissue ": 811.0982281260475, "Fall ": 7.769170378106752, "Gait disturbance ": 14.216737476896416, "Gait inability ": 5.978552544820518, "Generalised tonic-clonic seizure ": 11.65399367869762, "Loss of consciousness ": 2.000328761207167, "Loss of personal independence in daily activities ": 3.0102149107026435, "Medical device site discharge ": 4436.643070289055, "Medical device site erosion ": 2704.271097350109, "Medical device site infection ": 944.4046531340248, "Mobility decreased ": 6.415137612286107, "Multiple sclerosis ": 34.75634760554862, "Multiple sclerosis relapse ": 18.416880905597733, "Muscular weakness ": 5.029474515911486, "Musculoskeletal stiffness ": 2.989313744667246, "Neurotoxicity ": 15.890887142486475, "Pollakiuria ": 5.931940916156075, "Product substitution issue ": 60.77426743591488, "Seizure ": 2.232063742664674, "Staphylococcal infection ": 17.74879486115874, "Status epilepticus ": 12.605258572806523, "Therapy cessation ": 37.72586113632104, "Tremor ": 2.1573519936605483, "Urinary tract infection ": 3.3210228222224587, "Wound dehiscence ": 210.17914583594228} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/458.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/458.json new file mode 100644 index 00000000000..735abae9f46 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/458.json @@ -0,0 +1 @@ +{"Accident ": 10.083547691487958, "Acute disseminated encephalomyelitis ": 14.206156265711956, "Ankle fracture ": 5.198550466919186, "Ataxia ": 2.7133848378113123, "Balance disorder ": 11.360944307690714, "Bladder disorder ": 23.549927721857088, "Blood iron decreased ": 4.1191062719808205, "Blood test abnormal ": 5.662800251634595, "Brain neoplasm ": 3.674237714579912, "Caesarean section ": 3.2125760278947717, "Central nervous system lesion ": 8.34742246284733, "Constipation ": 2.367453132382024, "Coronavirus infection ": 23.26906898061623, "Cystitis ": 17.701344104971934, "Cystitis noninfective ": 29.185509481656677, "Dermatomyositis ": 8.371358691311203, "Dizziness ": 2.0183628388931005, "Drug ineffective ": 2.484481333663405, "Dysgraphia ": 4.572940615291889, "Dysstasia ": 7.538650716393929, "Electric shock sensation ": 2.327878863103464, "Epilepsy ": 7.162933786473334, "Euphoric mood ": 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": 32.28110392569897, "Muscle tightness ": 6.347879849822971, "Muscular weakness ": 3.7779090083358593, "Musculoskeletal disorder ": 23.05037899143051, "Nasopharyngitis ": 3.1290200671903023, "Nephrolithiasis ": 3.179608486618043, "Neuralgia ": 2.807592063739979, "Paraparesis ": 8.25838688906546, "Partial seizures ": 3.046019093501283, "Peroneal nerve palsy ": 8.648097353368252, "Poor quality sleep ": 15.788647883684892, "Prescribed underdose ": 17.568032037353976, "Primary progressive multiple sclerosis ": 614.9804246750336, "Product dose omission in error ": 35.238367265280324, "Product dose omission issue ": 6.633815060503122, "Product residue present ": 9.363383061255892, "Progressive multifocal leukoencephalopathy ": 6.029842328011755, "Progressive multiple sclerosis ": 152.731634913918, "Restless legs syndrome ": 3.876156547255435, "Secondary progressive multiple sclerosis ": 421.7103540247612, "Seizure ": 2.5709142900923694, "Sensory disturbance ": 3.2550162012007764, "Sleep 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/459.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/459.json new file mode 100644 index 00000000000..96d2a4b8b77 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/459.json @@ -0,0 +1 @@ +{"Acute respiratory failure ": 3.228040037309573, "Adrenal insufficiency ": 2.9001564677388982, "Anaphylactic reaction ": 4.69688118111868, "Appetite disorder ": 5.732178515833106, "Asthma ": 27.19732619552656, "Asthmatic crisis ": 17.05462748923231, "Blood immunoglobulin E increased ": 8.6905144511659, "Body height decreased ": 3.040878250516859, "Breast cancer female ": 7.11922868458, "Bronchial secretion retention ": 11.6796909652904, "Bronchiectasis ": 3.1338368606986813, "Bronchitis ": 3.236094928854714, "Bronchopulmonary aspergillosis ": 2.8358618755173035, "Bronchospasm ": 2.579408739712399, "COVID-19 pneumonia ": 2.7191144290205216, "Chest discomfort ": 2.2992454139522245, "Chronic obstructive pulmonary disease ": 2.562956076023725, "Cough ": 2.590465080581568, "Decreased activity ": 3.4317578075328647, "Device defective ": 18.528252573360245, "Device delivery system issue ": 21.61153615012997, "Device issue ": 4.170066217293395, "Device leakage ": 45.11851250063003, "Device malfunction ": 4.349305004311753, "Device use issue ": 28.55691187999221, "Drug dose omission by device ": 40.254897162202646, "Drug effect less than expected ": 13.273678429179885, "Dysphonia ": 3.427029109676699, "Dyspnoea ": 2.5345130508241764, "Ectopic pregnancy ": 10.090777460545578, "Eczema ": 2.596636665497345, "Eosinophil count abnormal ": 88.22478485582131, "Eosinophil count decreased ": 14.512679392957857, "Eosinophil count increased ": 46.630476579515296, "Eosinophilia ": 2.9617839800750385, "Eosinophilic granulomatosis with polyangiitis ": 38.27959933131371, "Eye disorder ": 2.434512807499739, "Forced expiratory volume decreased ": 14.035157058805105, "Frustration tolerance decreased ": 3.493919857149636, "Generalised oedema ": 2.1089210727636485, "Hypersensitivity ": 2.3942412351956426, "Illness ": 2.3052761084296542, "Immune system disorder ": 2.3549444258227687, "Inability to afford medication ": 15.378595623875018, "Inappropriate schedule of product administration ": 4.257741415837461, "Incorrect dose administered by device ": 14.852070981448565, "Injection site haemorrhage ": 3.484462650716836, "Injection site rash ": 4.209514037073743, "Insurance issue ": 27.6214310630625, "Lower respiratory tract infection ": 3.326421035960379, "Lung disorder ": 4.149015452965188, "Middle insomnia ": 4.018446164159955, "Multiple allergies ": 5.335703318262164, "Nasal congestion ": 3.5571198197191483, "Nasal polyps ": 49.50810648472746, "Nasopharyngitis ": 2.591100415508424, "Needle issue ": 6.533851924653591, "Obstructive airways disorder ": 3.967576993899162, "Organising pneumonia ": 4.02091734505425, "Oropharyngeal discomfort ": 2.621140735800155, "Oxygen saturation decreased ": 3.1457537149250325, "Pharyngitis ": 7.445291485187445, "Pneumonia ": 2.221811881966053, "Pneumonia bacterial ": 3.6744238650331686, "Polyneuropathy ": 2.126801695656414, "Product distribution issue ": 43.56567503761844, "Product dose omission issue ": 7.395340617177716, "Productive cough ": 4.283133141130589, "Pulmonary function test decreased ": 21.748748197553148, "Pulmonary mass ": 2.1948267348719708, "Pulmonary nocardiosis ": 152.91542792823836, "Pulmonary pain ": 3.2093941570550384, "Pustule ": 2.3954926159662078, "Rash pruritic ": 2.409210588587377, "Respiratory disorder ": 2.146611505602336, "Respiratory tract congestion ": 2.9221683638015103, "Rheumatic disorder ": 4.9959519892270565, "Rhinitis ": 4.311639311834452, "SARS-CoV-2 test negative ": 13.338254109417225, "Seasonal allergy ": 2.3333526677452032, "Secretion discharge ": 8.840548957168602, "Serum sickness ": 11.955447439779324, "Sinus disorder ": 3.828070718963246, "Sinusitis ": 2.948986213664691, "Skin plaque ": 2.3104415971961494, "Skin reaction ": 2.451679171130251, "Sleep disorder due to a general medical condition ": 2.431636024798509, "Symptom recurrence ": 18.220197870284245, "Therapeutic product effect decreased ": 2.2401234419993195, "Therapeutic response shortened ": 12.355770217074172, "Throat tightness ": 3.053162379418976, "Urticaria ": 2.979043332122493, "Viral infection ": 3.739458991447773, "Wheezing ": 7.998850976150823, "Wrong technique in device usage process ": 14.498826930334516} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/46.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/46.json new file mode 100644 index 00000000000..9d86e0e7fad --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/46.json @@ -0,0 +1 @@ +{"Disease progression ": 15.656924415897135, "Drug resistance ": 24.285949596603377, "Malignant neoplasm progression ": 15.509173382992389, "Maternal exposure during pregnancy ": 9.569216513522722, "Metastases to central nervous system ": 68.3430419709596, "Neoplasm progression ": 20.35142371057902} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/460.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/460.json new file mode 100644 index 00000000000..920a276288e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/460.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 2.5503264582655567, "Alopecia ": 2.8396993823035825, "Aphthous ulcer ": 2.233888037302952, "Ascites ": 3.364705001114162, "Back pain ": 2.482875367776743, "Blood oestrogen increased ": 18.73559942213892, "Body height decreased ": 12.636934433116048, "Bone cancer ": 14.068348745220472, "Bone cancer metastatic ": 49.590901015877954, "Bone lesion ": 18.20985051590945, "Bone pain ": 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4.858722266135065, "Full blood count decreased ": 6.017903672628327, "Gait disturbance ": 2.2563659897000767, "Haemoglobin decreased ": 2.4165839570644683, "Hair growth abnormal ": 2.4907961937178054, "Hepatic enzyme abnormal ": 2.501084647093605, "Hepatic failure ": 3.258113086575281, "Hepatic lesion ": 8.233547579008386, "Hepatic neoplasm ": 12.644570116089673, "Hip fracture ": 2.180316259294209, "Hot flush ": 5.2277386044018685, "Hydrocephalus ": 2.254379717153779, "Hydronephrosis ": 2.7969844117775, "Hypercalcaemia ": 2.2689823800182225, "Induration ": 5.237852693408737, "Injection site abscess ": 5.593973629299978, "Injection site bruising ": 4.192591382421722, "Injection site cellulitis ": 11.169839919279951, "Injection site cyst ": 71.52175056452691, "Injection site discomfort ": 7.944307935574326, "Injection site extravasation ": 4.766539149111688, "Injection site haematoma ": 2.8064359679209283, "Injection site haemorrhage ": 2.969183728394444, "Injection site hypersensitivity 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28.67899269633443, "Metastases to peritoneum ": 14.683666866126794, "Metastases to pleura ": 29.299990245235925, "Metastases to retroperitoneum ": 46.88225855015713, "Metastases to skin ": 49.99263942988155, "Metastases to spine ": 31.372114579649264, "Metastasis ": 21.737343461616373, "Metastatic neoplasm ": 9.008988128446756, "Micturition urgency ": 2.0256556982193974, "Muscle disorder ": 2.212891547088625, "Musculoskeletal chest pain ": 3.363373594974164, "Musculoskeletal pain ": 3.331166283301034, "Neoplasm malignant ": 2.3036640622120026, "Neoplasm progression ": 18.545883051019374, "Neoplasm recurrence ": 12.951661827650351, "Nerve injury ": 2.9801828876678647, "Neuropathy peripheral ": 3.2777487800950404, "Neutropenia ": 6.297976041067533, "Neutrophil count decreased ": 5.534118127648292, "Nodule ": 2.320247137948398, "Oestradiol increased ": 47.44933469930247, "Onychoclasis ": 10.256181100661582, "Onycholysis ": 13.875084389138015, "Osteonecrosis of jaw ": 5.800514772958016, "Pathological fracture ": 4.184496737752419, "Peripheral artery thrombosis ": 6.618018402267256, "Platelet count decreased ": 2.942446683226601, "Pleural effusion ": 4.804916245286972, "Product administered at inappropriate site ": 2.78276627057596, "Pulmonary embolism ": 2.0974131499327986, "Pulmonary mass ": 2.840537043293524, "Recurrent cancer ": 12.052633135715649, "Red blood cell count decreased ": 4.756909203148442, "Retinal vein occlusion ": 2.0723088938119933, "Sciatic nerve injury ": 17.58374903252399, "Sciatica ": 13.597141569898136, "Second primary malignancy ": 3.717046183262071, "Skin mass ": 2.422801549014618, "Skin odour abnormal ": 4.505935092948431, "Small intestinal obstruction ": 2.094098128506233, "Stomatitis ": 2.4537005814080484, "Terminal state ": 3.1303305151578966, "Throat tightness ": 2.2274904493956744, "Thyroid mass ": 3.3004081428988896, "Tooth disorder ": 2.627646482387695, "Tooth infection ": 4.251293909990223, "Trigger finger ": 6.558724169858598, "Tumour flare ": 39.26992092736663, "Tumour marker abnormal ": 58.23685796226458, "Tumour marker increased ": 110.92780135158068, "Urine odour abnormal ": 9.4735527255027, "Uterine cancer ": 2.462793266721403, "Vulvovaginal dryness ": 11.457254571015572, "Weight fluctuation ": 3.558198188071976, "White blood cell count abnormal ": 3.0729492724908445, "White blood cell count decreased ": 5.9082204564764655} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/461.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/461.json new file mode 100644 index 00000000000..a6493718ed6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/461.json @@ -0,0 +1 @@ +{"Anaphylactic reaction ": 5.574614210389711, "Anaphylactic shock ": 16.892588066902487, "Blood bilirubin increased ": 9.020605055814965, "Blood pressure decreased ": 3.5457856302223734, "Blood uric acid increased ": 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/462.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 7.108204797090248, "Acute kidney injury ": 4.005754327398509, "Acute myocardial infarction ": 21.613647337196824, "Angina pectoris ": 3.3446336817222884, "Blood creatine phosphokinase increased ": 3.293127864291897, "Blood creatinine increased ": 2.9787129082923007, "Blood urea increased ": 3.647447341047908, "Blood uric acid increased ": 10.315619217620414, "Cardiac failure ": 4.268200564347088, "Cardiac failure congestive ": 5.467350971924363, "Cellulitis ": 2.1137575478070527, "Cerebrovascular accident ": 2.759200813196794, "Coronary artery disease ": 8.957164346603985, "Drug eruption ": 8.88118744589666, "Drug interaction ": 3.087663455570989, "Drug reaction with eosinophilia and systemic symptoms ": 5.735128153546387, "Drug-induced liver injury ": 16.90077750493516, "Eosinophilia ": 3.658325672210787, "Gout ": 90.03909919508094, "Hepatic enzyme increased ": 2.880551215072052, "Hepatic failure ": 3.566373352290183, "Hepatic function abnormal ": 10.761300746992374, "Hepatitis acute ": 11.846524798139164, "Hyperkalaemia ": 3.0064749936535566, "Hypersensitivity vasculitis ": 37.9628319273163, "Jaundice ": 2.659373579356497, "Liver disorder ": 6.650367268911463, "Liver function test abnormal ": 6.175604854779799, "Liver injury ": 5.979765053244534, "Lung neoplasm malignant ": 3.855896899204271, "Melaena ": 2.226279260344153, "Myocardial infarction ": 5.898233011785821, "Nephrolithiasis ": 3.474103664860489, "Oedema peripheral ": 2.0153264957652595, "Pancytopenia ": 5.428976435862894, "Platelet count decreased ": 2.8055667966060978, "Prescribed underdose ": 8.9209062405223, "Procedural haemorrhage ": 48.5525773713977, "Pulmonary haemorrhage ": 15.529225430457023, "Rash ": 2.7367717843010047, "Rash maculo-papular ": 2.8490280836336064, "Renal failure ": 2.870292419130249, "Renal impairment ": 5.16916590349279, "Renal tubular necrosis ": 12.729132856234658, "Rhabdomyolysis ": 13.469588248387131, "Sepsis ": 2.1847203135731004, "Stevens-Johnson syndrome ": 11.081747040054172, "Thrombocytopenia ": 2.1736411903379147, "Toxic epidermal necrolysis ": 6.188260503623746, "Transaminases increased ": 2.3425892250300486, "Tubulointerstitial nephritis ": 8.222750106862218, "Underdose ": 4.828899641593568, "Wrong technique in product usage process ": 2.6376589170415925} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/463.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/463.json new file mode 100644 index 00000000000..f87424d4e43 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/463.json @@ -0,0 +1 @@ +{"Therapy non-responder ": 36.52501155175752, "Vaccination site pain ": 4.011770971260221} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/464.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/464.json new file mode 100644 index 00000000000..1ec77930e51 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/464.json @@ -0,0 +1 @@ +{"Abortion induced ": 4.2071146256265815, "Abscess neck ": 20.64842232043754, "Accidental death ": 6.42308397006293, "Accidental overdose ": 7.2996733370029565, "Acute hepatic failure ": 2.4535375489450595, "Acute postoperative sialadenitis ": 140.24359105862902, "Acute pulmonary oedema ": 5.019668337241424, "Acute respiratory distress syndrome ": 3.383247071842733, "Acute respiratory failure ": 2.5682955349649728, "Agitation ": 2.5947463163062165, "Agoraphobia ": 6.628425222830841, "Air embolism ": 25.09130461032556, "Airway complication of anaesthesia ": 43.75810272349158, "Airway peak pressure increased ": 104.37878587281892, "Alcohol poisoning ": 9.248621321884372, "Allodynia ": 11.039151617949608, "Amphetamines positive ": 104.61975909858396, "Anaesthetic complication ": 17.957182115850124, "Anaesthetic complication neurological ": 6.453731344829355, "Anaphylactic reaction ": 8.240833694520294, "Anaphylactic shock ": 5.619690709521088, "Anaphylactoid reaction ": 7.430705083076045, "Anaphylactoid shock ": 3.826588555309565, "Anisocoria ": 8.32515792633657, "Anterior spinal artery syndrome ": 103.42466271312291, "Anticholinergic syndrome ": 8.217520547646828, "Anuria ": 2.5494728896214656, "Anxiety disorder ": 3.0424164833954426, "Apgar score abnormal ": 47.98164838974555, "Apgar score low ": 48.86600054913171, "Apnoea ": 14.506630989042293, "Apnoeic attack ": 16.41262609313192, "Arachnoiditis ": 14.485197907476818, "Areflexia ": 6.642433644537372, "Arteriospasm coronary ": 6.20954473958047, "Arthritis bacterial ": 2.8722758902854246, "Asphyxia ": 2.912225358882385, "Atelectasis ": 2.038881015674296, "Atrioventricular block 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3.320140851574768, "Bundle branch block right ": 2.224249063477062, "Caesarean section ": 6.348876033352314, "Carbon dioxide decreased ": 5.262965340808649, "Carbon dioxide increased ": 5.111180079081104, "Carcinoid crisis ": 30.788693596009043, "Carcinoid tumour ": 9.24313640406652, "Cardiac arrest ": 8.814090582817029, "Cardiac death ": 44.002471369857226, "Cardiac dysfunction ": 2.4032192247223905, "Cardiac hypertrophy ": 4.756330496655121, "Cardio-respiratory arrest ": 6.978938647806461, "Cardiogenic shock ": 2.469325583894748, "Cardiomegaly ": 2.3016551892751624, "Cerebrospinal fluid leakage ": 5.50975895025987, "Chest injury ": 3.4745002250455737, "Circulatory collapse ": 3.966666548262004, "Clonus ": 14.393011263304532, "Coagulopathy ": 2.2446732471581963, "Coma ": 2.759728625273288, "Coma scale abnormal ": 3.974613394032374, "Communication disorder ": 2.6818842977971213, "Compartment syndrome ": 7.298027924456704, "Completed suicide ": 3.276610567482437, "Conversion disorder ": 5.340141580600066, "Counterfeit product administered ": 24.72306468004015, "Crohn's disease ": 2.2393354674762733, "Cyanosis ": 2.88588155336766, "Death ": 2.066776364737558, "Delayed recovery from anaesthesia ": 65.69867556016085, "Delirium ": 3.1719856674621023, "Dependence ": 12.019595835912796, "Depressed level of consciousness ": 3.888916619398965, "Developmental delay ": 2.872340659376473, "Device failure ": 2.0016407519603767, "Diabetes insipidus ": 3.220891315573557, "Diastolic dysfunction ": 3.887313282828965, "Diffuse alveolar damage ": 6.016019842189261, "Diplegia ": 3.265968730831285, "Drug abuse ": 17.29344793210555, "Drug dependence ": 11.887994963104846, "Drug detoxification ": 24.90546835726349, "Drug diversion ": 16.69725031820183, "Drug interaction ": 4.036481172856109, "Drug level increased ": 2.729705811669638, "Drug screen positive ": 3.08417551425806, "Drug tolerance ": 34.39693456231795, "Drug tolerance increased ": 23.710588322222087, "Drug use disorder ": 12.25285214192226, "Drug withdrawal syndrome ": 9.800891134834744, "Drug withdrawal syndrome neonatal ": 5.2008662295247285, "Drug-genetic interaction ": 43.36408383041438, "Duodenitis ": 2.5523132622547764, "Dysarthria ": 2.4714655861900905, "Dyskinesia ": 2.161877941377553, "Dysphemia ": 2.8303114303977708, "Electrocardiogram P wave abnormal ": 20.19664212181884, "Electrocardiogram ST segment depression ": 20.669784717168607, "Electrocardiogram ST segment elevation ": 9.770150398323102, "Electrocardiogram T wave abnormal ": 4.756330496655121, "Electrocardiogram T wave amplitude decreased ": 16.028168028548233, "Electrocardiogram T wave inversion ": 4.420116069736779, "Electrocardiogram abnormal ": 4.748316750827945, "Electroencephalogram abnormal ": 4.992944654996113, "Emotional disorder ": 4.022202891379808, "End-tidal CO2 decreased ": 52.4928000562922, "End-tidal CO2 increased ": 225.31315390040407, "Endometriosis ": 2.128864621206541, "Euphoric mood ": 4.371573184279029, "Ewing's sarcoma ": 24.16509020851709, "Exposure during pregnancy ": 6.42488915295431, "Extensor plantar response ": 3.9304131438209375, "Extradural abscess ": 29.339257030381468, "Extradural haematoma ": 3.016220632478895, "Extravasation ": 3.6286833879492537, "Faecaloma ": 3.01628314105686, "Fibrin D dimer increased ": 2.531645014641277, "Foaming at mouth ": 2.240787056722896, "Foetal death ": 7.377978935306902, "Foetal distress syndrome ": 6.858775124066405, "Foetal exposure during delivery ": 35.092797117903395, "Foetal exposure during pregnancy ": 6.353202509714267, "Foetal exposure timing unspecified ": 4.532497540841885, "Foetal growth restriction ": 2.7118104232897347, "Foetal heart rate abnormal ": 10.61756680091137, "Foetal heart rate deceleration abnormality ": 54.11360628368904, "Foetal heart rate decreased ": 31.12576914329544, "Foetal hypokinesia ": 4.788915631246089, "Foreign body reaction ": 49.784648327956766, "Functional gastrointestinal disorder ": 19.151315494064114, "Gastric dilatation ": 38.80431604176108, "Generalised tonic-clonic seizure ": 3.3452474080702075, "Glassy eyes ": 10.549928416565864, "Globulins increased ": 26.93083447647913, "Glossoptosis ": 13.44333609696427, "Gun shot wound ": 5.6548003834943055, "Haemodynamic instability ": 10.61494733359656, "Heart rate decreased ": 3.0916025010631323, "Hemiplegic migraine ": 14.850888533746913, "Homeless ": 63.09294832643059, "Horner's syndrome ": 64.93945018368528, "Hyperaesthesia ": 7.850210768641397, "Hypercapnia ": 18.248957998829145, "Hyperdynamic left ventricle ": 25.32730947348779, "Hyperreflexia ": 4.393008914264482, "Hypertensive heart disease ": 3.068442710570729, "Hyperthermia ": 2.203080097132748, "Hyperthermia malignant ": 87.38915253841068, "Hypertonia ": 2.2559107192483365, "Hypopnoea ": 3.9371500958496126, "Hypotension ": 6.427012657461907, "Hypothermia ": 3.547473153398565, "Hypotonia neonatal ": 5.272014947658747, "Hypoventilation ": 15.435268910019031, "Hypoxia ": 5.541835219371921, "Hypoxic-ischaemic encephalopathy ": 10.731963761292471, "Ileus ": 2.458098054895996, "Impaired driving ability ": 4.005052646931335, "Implant site extravasation ": 11.508013788723003, "Implant site infection ": 7.811672384566375, "Implant site pain ": 12.44916203590515, "Inadequate analgesia ": 17.05233650416307, "Incorrect drug administration rate ": 2.596427325467257, "Incorrect route of product administration ": 11.544105258675051, "Increased bronchial secretion ": 7.792482361240531, "Infantile apnoea ": 6.199417624623381, "Infusion site extravasation ": 2.8897352579019158, "Infusion site mass ": 23.9578032001368, "Inspiratory capacity decreased ": 193.44620542160672, "Intensive care unit acquired weakness ": 56.58658394473184, "Intentional product misuse ": 6.378797461038319, "Intentional underdose ": 2.8870371784719087, "Intestinal stenosis ": 5.955685836066354, "Judgement impaired ": 4.735597189916646, "Laryngeal obstruction ": 26.990544399668916, "Laryngospasm ": 11.347953238655776, "Learning disability ": 14.244939598272488, "Lip ulceration ": 5.351134311401888, "Live birth ": 12.979508841692985, "Loss of consciousness ": 2.154797297701909, "Loss of employment ": 5.287964521708748, "Low birth weight baby ": 11.956497498762486, "Maternal exposure during delivery ": 34.60321775898639, "Maternal exposure during pregnancy ": 3.5402526692869505, "Maternal exposure timing unspecified ": 8.419994895328559, "Mean arterial pressure decreased ": 40.533543464208, "Mechanical ventilation ": 3.632316812850788, "Mechanical ventilation complication ": 25.83484401047674, "Medical device discomfort ": 28.25812347954277, "Medication error ": 2.242022671841251, "Meningitis bacterial ": 4.975531752367867, "Mental impairment ": 3.650724815348212, "Mental status changes ": 3.38568436795332, "Mental status changes postoperative ": 183.23582245372936, "Metabolic acidosis ": 2.8832795303616634, "Miosis ": 5.749754174117107, "Mucosal ulceration ": 5.451851313915949, "Multiple-drug resistance ": 2.277454642999196, "Muscle rigidity ": 5.948349740943895, "Muscle tension dysphonia ": 314.2128633340365, "Mydriasis ": 6.625640480151256, "Myocardial ischaemia ": 3.346437421271826, "Myoclonus ": 7.611023273666915, "Myoglobin urine present ": 23.217841444389503, "Near death experience ": 2.0506677416020453, "Negative pressure pulmonary oedema ": 56.00423894665031, "Neonatal asphyxia ": 22.532570472543192, "Neonatal disorder ": 37.92941563518856, "Neonatal respiratory depression ": 26.817869729866047, "Neonatal respiratory distress syndrome ": 4.426249098648336, "Neuromuscular block prolonged ": 38.00750708633272, "Neuromuscular blockade ": 14.29982238485408, "Neurotoxicity ": 2.2358258002870186, "Nodal rhythm ": 3.9543557923764863, "Non-cardiogenic pulmonary oedema ": 24.41356537493828, "Nonreassuring foetal heart rate pattern ": 31.56208891603267, "Normal newborn ": 2.2290312082333186, "Nystagmus ": 3.4946520636026346, "Obstructive airways disorder ": 3.5871798139939344, "Oligohydramnios ": 3.814538290374758, "Opiates positive ": 159.00956045926398, "Optic neuropathy ": 2.9427098556537303, "Oral mucosa erosion ": 7.29917373500387, "Overdose ": 8.098521277133903, "Oxygen saturation abnormal ": 3.596827998485142, "Oxygen saturation decreased ": 6.764085227172628, "PCO2 increased ": 22.146796648540803, "PO2 decreased ": 7.283054513893038, "Palatal oedema ": 2.317367865057454, "Paralysis ": 2.978347207075359, "Paraplegia ": 6.703989195356158, "Pathological fracture ": 3.1348902050892264, "Peripheral nerve injury ": 8.878903296595146, "Personal relationship issue ": 12.149594455958894, "Pharyngeal hypoaesthesia ": 10.43780825965789, "Pharyngeal paraesthesia ": 5.064529233621383, "Piloerection ": 11.250486260647172, "Placental transfusion syndrome ": 81.05291178788833, "Pneumomediastinum ": 4.810580710742442, "Pneumonia klebsiella ": 4.227290972781793, "Pneumonitis aspiration ": 7.207044266393752, "Pneumothorax ": 3.6752909157471545, "Poisoning ": 2.2961316950707533, "Polyhydramnios ": 6.061605785391556, "Poor quality product administered ": 3.316362977451846, "Post lumbar puncture syndrome ": 6.156961969546647, "Post procedural complication ": 9.0085269394889, "Post-traumatic stress disorder ": 4.977870474441823, "Postmortem blood drug level ": 1503.0517445598343, "Postmortem blood drug level increased ": 51.36534182441573, "Postoperative delirium ": 17.049781696539725, "Postpartum haemorrhage ": 5.619038551548635, "Potentiating drug interaction ": 6.544467520121809, "Pre-eclampsia ": 3.1789544420932403, "Pregnancy ": 2.0975540920171123, "Premature baby ": 11.979472137574987, "Premature delivery ": 8.013375404072494, "Premature labour ": 3.516427589228427, "Prescription drug used without a prescription ": 3.997754490630531, "Prinzmetal angina ": 14.71802832294206, "Procedural complication ": 5.280819042523384, "Procedural hypotension ": 68.12447363244294, "Procedural nausea ": 78.97129346318529, "Procedural pain ": 2.671830534646184, "Procedural vomiting ": 67.02332752202292, "Proctalgia ": 2.085661934963761, "Product adhesion issue ": 3.928994117267088, "Product administered at inappropriate site ": 3.613940079394489, "Product counterfeit ": 13.172184782434034, "Product prescribing error ": 2.1876603930230245, "Propofol infusion syndrome ": 4.302918743034548, "Psychiatric symptom ": 2.146924073746344, "Psychotic behaviour ": 5.729701530413742, "Pulmonary congestion ": 4.156492551291826, "Pulmonary haemorrhage ": 2.599983557758034, "Pulmonary oedema ": 6.271926207127636, "Pulse absent ": 10.95795401798436, "Pulseless electrical activity ": 16.118523571107573, "Pupil fixed ": 11.73583860964222, "Pupillary reflex impaired ": 3.052718071617359, "Purulent discharge ": 3.0781380524960458, "Quadriparesis ": 6.946663516619, "Respiratory acidosis ": 18.08748117714124, "Respiratory arrest ": 13.298781485110222, "Respiratory depression ": 25.508194642826528, "Respiratory distress ": 2.4036193541140327, "Respiratory rate decreased ": 10.21469051669647, "Resuscitation ": 3.0561816175850622, "Rhabdomyolysis ": 2.507538097464725, "Rhythm idioventricular ": 31.23020350990429, "Road traffic accident ": 2.1382051666997635, "Scratch ": 2.553297347308721, "Sedation ": 6.116253588701886, "Sedation complication ": 5.152587982187614, "Seizure like phenomena ": 4.792844770596524, "Sensory loss ": 2.9404683693109024, "Serotonin syndrome ": 10.94243491644446, "Sinus arrest ": 3.214163361885351, "Sinus bradycardia ": 2.5411742579222394, "Sinus node dysfunction ": 3.796692923995449, "Skin abrasion ": 4.842838896628899, "Skin test positive ": 3.685225804978232, "Slow response to stimuli ": 2.668627871806605, "Snoring ": 5.776372096461027, "Somatic symptom disorder ": 4.019509959146072, "Somnolence ": 2.289324305510296, "Spinal cord compression ": 2.840157926403608, "Spinal cord infarction ": 36.188196491705305, "Spinal cord injury ": 13.478192536284284, "Spinal cord oedema ": 26.8421862078261, "Spinal epidural haematoma ": 6.40767431183129, "Stereotypy ": 7.884847136989245, "Stress cardiomyopathy ": 13.260817571646328, "Stridor ": 3.0890755972522137, "Stupor ": 2.546429465014924, "Substance abuse ": 22.12665117972758, "Substance dependence ": 51.45855411735601, "Substance use disorder ": 10.91022446190004, "Supraventricular tachycardia ": 2.3549809558614494, "Suspected suicide ": 3.929661550782338, "Tachycardia ": 2.3938711204929803, "Tachycardia foetal ": 11.79496559070308, "Therapeutic product effect increased ": 3.1690337924431287, "Thyrotoxic crisis ": 4.652714006793215, "Torsade de pointes ": 2.134454085751316, "Toxicity to various agents ": 16.303377521993667, "Toxicologic test abnormal ": 16.334726387681624, "Tryptase increased ": 12.732089706124317, "Type I hypersensitivity ": 2.821553222754226, "Unevaluable event ": 3.3215669157778365, "Unresponsive to stimuli ": 11.925569817864371, "Unwanted awareness during anaesthesia ": 119.16569296340666, "Upper airway obstruction ": 28.21591087237004, "Urinary retention ": 2.3402670069900107, "Urine analysis abnormal ": 4.885538665302246, "Uterine hypotonus ": 21.04183814281389, "Vasoplegia syndrome ": 5.809267835119951, "Vein collapse ": 19.32095491643746, "Ventilation perfusion mismatch ": 28.332936677229466, "Ventricular arrhythmia ": 2.031737380088883, "Ventricular extrasystoles ": 4.135826132847813, "Ventricular fibrillation ": 5.765802977874911, "Ventricular hypokinesia ": 7.549402174713726, "Ventricular tachycardia ": 6.070580028612318, "Withdrawal syndrome ": 4.755818931081166, "Wrong product administered ": 2.193926868898389, "Wrong technique in product usage process ": 2.1604952900412937, "X-ray abnormal ": 5.793442365188687} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/465.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/465.json new file mode 100644 index 00000000000..8b412eb554d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/465.json @@ -0,0 +1 @@ +{"Amnesia ": 32.82498513043153, "Aphasia ": 49.54845343347981, "Bradycardia ": 20.254344539294195, "Brain injury ": 172.84067716290758, "Cardiac arrest ": 14.19815081421435, "Cardiomegaly ": 78.21093456841346, "Cerebral infarction ": 51.30963731475755, "Cerebrovascular accident ": 12.30039743852318, "Drug effect less than expected ": 154.80469089025684, "Drug ineffective ": 2.252733573468947, "Dry mouth ": 8.070593073087295, "Dysstasia ": 16.552969929075235, "Electrocardiogram QRS complex prolonged ": 339.64979337597475, "Fall ": 3.317218707601008, "Fracture ": 14.77680835255884, "Hypotension ": 7.466608455221339, "Loss of consciousness ": 25.641298123479583, "Muscle spasms ": 3.0627913244552927, "Off label use ": 2.1284978363189806, "Overdose ": 31.18354674290772, "Product use in unapproved indication ": 2.2673919750005016, "Product use issue ": 11.161460207839356, "Pulseless electrical activity ": 1101.004184712733, "Syncope ": 2.217014829431105, "Tendon disorder ": 61.27244894001729, "Transient ischaemic attack ": 51.72925328426641, "Urinary incontinence ": 19.09595546932221, "Vertigo ": 3.2623678498331685} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/466.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/466.json new file mode 100644 index 00000000000..527cdc54600 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/466.json @@ -0,0 +1 @@ +{"Accidental overdose ": 2.3082973785057344, "Blood glucose abnormal ": 48.16387219679721, "Blood glucose decreased ": 18.604139531717763, "Blood glucose fluctuation ": 67.73853125733328, "Blood glucose increased ": 51.15097948118381, "Dermatitis allergic ": 2.4324985569331963, "Device breakage ": 56.77109366926445, "Device defective ": 27.124172231285534, "Device delivery system issue ": 28.747244215367296, "Device failure ": 51.78681692416048, "Device information output issue ": 327.0282534630534, "Device issue ": 27.18678435800706, "Device leakage ": 14.11204681725067, "Device malfunction ": 16.34425790201519, "Device occlusion ": 26.09973944828613, "Diabetes mellitus inadequate control ": 16.224442829860095, "Diabetic ketoacidosis ": 14.361551521574516, "Diabetic metabolic decompensation ": 34.569788537965614, "Drug delivery system issue ": 77.45257335122263, "Drug ineffective ": 5.730885508635657, "Exposure during pregnancy ": 3.109100805782613, "Extra dose administered ": 13.381476451202452, "Glycosylated haemoglobin increased ": 7.972596007124737, "Hyperglycaemia ": 40.09639672669617, "Hypoglycaemia ": 24.243658807805605, "Hypoglycaemic unconsciousness ": 20.909130686505648, "Incorrect dose administered ": 2.7544054038301087, "Incorrect dose administered by device ": 86.41306673308985, "Increased insulin requirement ": 353.48249504892163, 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1916.530692084404, "Product leakage ": 30.916721805438318, "Product physical issue ": 58.579206366307375, "Product quality issue ": 29.742685640781005, "Product storage error ": 16.45900668133971, "Therapeutic product effect decreased ": 10.722730805040737, "Therapeutic product effect delayed ": 150.4986571043564, "Therapeutic product effect variable ": 53.12841230499329, "Thirst ": 4.151856781163862, "Weight increased ": 2.7027494550528663, "Wrong product administered ": 48.52442661959076, "Wrong technique in device usage process ": 9.875135843276365, "Wrong technique in product usage process ": 6.770485719468444} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/467.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/467.json new file mode 100644 index 00000000000..8e8d77f9d46 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/467.json @@ -0,0 +1 @@ +{"Clostridium difficile colitis ": 52.24160712664252, "Clostridium difficile infection ": 919.7556850050524, "Diarrhoea ": 2.630815024727764, "Disease recurrence ": 21.4153122058721, "Drug ineffective ": 5.002926254665314, "Drug interaction ": 3.104742663126507, "Drug resistance ": 16.348234021143536, "Septic shock ": 15.916624274892069, "Treatment failure ": 21.178076018884656} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/468.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/468.json new file mode 100644 index 00000000000..8937e0abaae --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/468.json @@ -0,0 +1 @@ +{"Acute febrile neutrophilic dermatosis ": 49.66079651931088, "Acute myeloid leukaemia ": 14.557095345878752, "Acute myeloid leukaemia recurrent ": 24.1706337116965, "Acute respiratory distress syndrome ": 5.646135107770378, "Acute respiratory failure ": 4.631085458461365, "Adenovirus infection ": 14.02168012438511, "Agranulocytosis ": 6.656439416068348, "Anaemia ": 2.4492796982352885, "Aortitis ": 124.04884208021328, "Bacterial infection ": 5.667570815093459, "Blood lactate dehydrogenase increased ": 2.6534633858601646, "Blood magnesium decreased ": 14.911725946718452, "Blood test abnormal ": 5.862678694532354, "Bone marrow failure ": 9.8705142543334, "Bone pain ": 13.280394044322543, "Brain oedema ": 3.664707415618436, "Bronchopulmonary aspergillosis ": 10.11119033701555, "Capillary leak syndrome ": 33.26666426524781, "Catheter site infection ": 25.24170152175138, "Clostridium difficile infection ": 9.345076437717816, "Coagulopathy ": 2.1561617411715326, "Cytopenia ": 13.273573849627804, "Disease progression ": 5.691044539623913, "Drug exposure before pregnancy ": 323.0463228627666, "Drug ineffective for unapproved indication ": 5.033851958869401, "Enteritis ": 11.024011570548574, "Febrile neutropenia ": 35.835060872544766, "Fungal 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"Meningitis tuberculous ": 94.97647903946046, "Metastases to liver ": 2.8805693342087046, "Metastases to lung ": 3.06413385708991, "Metastases to lymph nodes ": 5.741533166035016, "Mouth ulceration ": 4.5161053343012325, "Mucosal inflammation ": 12.74216972681663, "Multiple organ dysfunction syndrome ": 5.779657534825653, "Muscle twitching ": 2.3890805251928344, "Myelodysplastic syndrome ": 13.501437347217127, "Neoplasm progression ": 4.055131988845357, "Nervous system disorder ": 2.3308717899712668, "Neuropathy peripheral ": 3.150272808188062, "Neurotoxicity ": 4.538518941240761, "Neutropenia ": 8.73692701372425, "Neutropenic sepsis ": 19.917272888526316, "Neutrophil count decreased ": 2.8221663869961584, "Neutrophil count increased ": 13.52660983739053, "Neutrophilia ": 17.766347641778545, "Off label use ": 3.128737067711662, "Pancytopenia ": 3.626621420261626, "Pericardial effusion ": 2.1902240367957204, "Plasma cell myeloma ": 2.186982839596736, "Platelet count decreased ": 3.1915693329160493, "Pleural effusion ": 2.5036895903331797, "Pneumonitis ": 4.767284495053123, "Product use in unapproved indication ": 2.904038044521989, "Productive cough ": 2.0603241596788977, "Progressive multifocal leukoencephalopathy ": 15.817642690554772, "Respiratory failure ": 2.048005719132473, "Sepsis ": 4.1493828570764935, "Septic shock ": 2.58453074251702, "Skin lesion ": 2.3315305593421614, "Skin toxicity ": 7.554563587363239, "Splenic rupture ": 32.08687973890925, "Staphylococcal bacteraemia ": 43.407933374971314, "Staphylococcal infection ": 2.398277542913114, "Tachypnoea ": 2.245706652746456, "Therapy non-responder ": 7.107143970973526, "Therapy partial responder ": 13.53813885111127, "Thrombocytopenia ": 3.8939351499239487, "Toxic epidermal necrolysis ": 2.8568773211861616, "Treatment failure ": 2.052303375484998, "Ureteric obstruction ": 64.22892884661363, "Vasculitis ": 2.6227559250273336, "Venoocclusive liver disease ": 7.766363574614862, "Viral infection ": 4.9977116655340055, "White blood cell count decreased ": 3.775530833965232, "White blood cell count increased ": 6.608190500451387} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/469.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/469.json new file mode 100644 index 00000000000..0abef1179c9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/469.json @@ -0,0 +1 @@ +{"Electrocardiogram T wave inversion ": 419.3855741897945, "Multiple sclerosis relapse ": 43.94406459061196} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/47.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/47.json new file mode 100644 index 00000000000..5273ac81725 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/47.json @@ -0,0 +1 @@ +{"Acquired haemophilia ": 19.142103368940788, "Acute graft versus host disease ": 62.7659728197267, "Acute graft versus host disease in intestine ": 74.40462534909389, "Acute graft versus host disease in liver ": 24.44637553113779, "Acute graft versus host disease in skin ": 31.71298872039715, "Acute myeloid leukaemia recurrent ": 8.578952651329592, "Acute respiratory distress syndrome ": 3.17974527033292, "Adenovirus infection ": 181.3710850576448, "Anti-thyroid antibody positive ": 24.57803533114699, "Aplasia pure red cell ": 9.825559097273809, "Aplastic anaemia ": 23.593529507529723, "Aspergillus infection ": 15.192759030826885, "Autoimmune haemolytic anaemia ": 54.66889530640226, "Autoimmune hypothyroidism ": 50.54028524505242, "Autoimmune thyroiditis ": 15.36116696269174, "BK virus infection ": 72.44399289206207, "Bacteraemia ": 11.823711518616143, "Bacterial infection ": 2.1116822650164377, "Bacterial sepsis ": 18.61122825673286, "Bacterial test ": 95.23203747798289, "Bacterial test positive ": 35.25162962343912, "Blood stem cell transplant failure ": 186.24789616974712, "Blood thyroid stimulating hormone decreased ": 15.298033765541591, "Blood thyroid stimulating hormone increased ": 3.1351899913100523, "Blood urine present ": 10.536571524487783, "Bone marrow failure ": 3.599763130981557, "Bone marrow transplant rejection ": 59.13026142906176, "Bronchiolitis obliterans syndrome ": 153.73646169965403, "Bronchopulmonary aspergillosis ": 17.595827731929738, "Candida infection ": 2.1130527141253905, "Central nervous system lesion ": 8.794277114750273, "Central nervous system lymphoma ": 24.31886633760292, "Cerebral aspergillosis ": 86.48771128702572, "Chronic graft versus host disease ": 23.88828271556361, "Chronic graft versus host disease in liver ": 58.221015752229405, "Chronic graft versus host disease in skin ": 84.82905826222768, "Chronic lymphocytic leukaemia ": 7.409467667290668, "Clostridium difficile infection ": 5.1170895895187405, "Complications of bone marrow transplant ": 85.14854147169456, "Coronavirus infection ": 6.08571060657496, "Crystal urine present ": 149.01850558435518, "Cutibacterium acnes infection ": 165.522126255569, "Cystitis haemorrhagic ": 9.668588880133129, "Cystitis viral ": 77.784604009242, "Cytomegalovirus chorioretinitis ": 16.31098753697818, "Cytomegalovirus infection ": 49.749617055749, "Cytomegalovirus infection reactivation ": 123.14195675160046, "Cytomegalovirus viraemia ": 70.69391237765147, "Cytopenia ": 5.205078316545678, "Device related infection ": 2.451565360099706, "Diarrhoea haemorrhagic ": 2.96144904830488, "Diarrhoea infectious ": 32.928132622496214, "Diffuse large B-cell lymphoma ": 15.042745800948628, "Diplopia ": 2.3841301015843754, "Disability ": 2.2511499766809986, "Disseminated Bacillus Calmette-Guerin infection ": 95.58470525823957, "Disseminated tuberculosis ": 21.420462696752278, "Drug exposure before pregnancy ": 16.82372605027741, "Drug ineffective for unapproved indication ": 4.901909959900498, "Drug resistance ": 4.3984065013946, "Dry throat ": 4.159068227391758, "Encephalitis ": 3.5965050458968038, "Encephalitis viral ": 48.67129686049386, "End stage renal disease ": 18.0307891808845, "Endocrine ophthalmopathy ": 34.06964272326116, "Enteritis ": 9.87963793545645, "Enterobacter bacteraemia ": 131.083245861796, "Enterobacter infection ": 17.30393805754053, "Enterococcal bacteraemia ": 45.70661841003324, "Enterococcal infection ": 13.504357997265055, "Eosinophil count increased ": 5.139019804658902, "Epstein-Barr viraemia ": 135.55232041199235, "Epstein-Barr virus associated lymphoma ": 59.39847357271024, "Epstein-Barr virus associated lymphoproliferative disorder ": 29.32513532776924, "Epstein-Barr virus infection ": 40.770837514778975, "Epstein-Barr virus infection reactivation ": 46.879622719835815, "Escherichia bacteraemia ": 23.60937498931075, "Escherichia infection ": 7.273490341528614, "Escherichia urinary tract infection ": 15.179849052956891, "Exophthalmos ": 9.263510180266522, "Febrile neutropenia ": 4.413969588305796, "Flushing ": 2.7850268086262484, "Fungaemia ": 14.060997500515118, "Fungal infection ": 3.922881657236138, "Gastroenteritis ": 3.075669665353677, "Gastroenteritis adenovirus ": 189.560551622362, "Gastroenteritis norovirus ": 36.64665719727967, "Goitre ": 5.513325469285062, "Graft loss ": 67.08965016411776, "Graft versus host disease ": 40.33917729872454, "Graft versus host disease in gastrointestinal tract ": 32.958702216088405, "Graft versus host disease in skin ": 77.87851517315042, "Granuloma ": 10.468145625487544, "Graves' disease ": 48.07766711559017, "Grip strength decreased ": 2.982527248391108, "Haematocrit decreased ": 2.845809387099111, "Haemolytic anaemia ": 2.274984991949653, "Haemophagocytic lymphohistiocytosis ": 18.731535804325123, "Heart rate decreased ": 2.591183967688109, "Hemiparesis ": 2.2344852332545564, "Hepatitis B ": 14.717400918668078, "Hepatosplenomegaly ": 8.69857985981491, "Herpes simplex ": 50.22142242801687, "Herpes virus infection ": 2.474231961773608, "Herpes zoster disseminated ": 24.0122824094106, "Human herpesvirus 6 infection ": 123.29535663017454, "Human herpesvirus 6 infection reactivation ": 93.84321926661865, "Human polyomavirus infection ": 94.26560487904035, "Hydrocephalus ": 4.752369327297212, "Hyperthyroidism ": 7.394679872864422, "Hypertransaminasaemia ": 4.149325553018896, "Hypervolaemia ": 3.215750790250513, "Hypogammaglobulinaemia ": 13.786378272875783, "Immune reconstitution inflammatory syndrome ": 4.207156710514938, "Immune system disorder ": 3.223893880663861, "Immune thrombocytopenia ": 11.617157084676991, "Immunosuppression ": 8.447408302109308, "Increased appetite ": 2.082442139972103, "Increased tendency to bruise ": 3.2210497797976574, "Infection ": 3.1969882535044176, "Infusion site erythema ": 5.745024877636352, "Infusion site extravasation ": 18.968352798601163, "Infusion site pain ": 5.901168180737076, "Iron overload ": 25.589993467539543, "JC virus infection ": 87.05177335830737, "Kidney transplant rejection ": 14.16225761455937, "Klebsiella bacteraemia ": 47.38951551940746, "Klebsiella infection ": 8.117481577300529, "Klebsiella sepsis ": 17.566062512342242, "Leukaemia recurrent ": 22.67287098012612, "Listeriosis ": 45.08557899441609, "Lung infiltration ": 3.77877024318674, "Lymphocyte count decreased ": 27.1582447485189, "Lymphocyte percentage decreased ": 48.71873892507818, "Lymphopenia ": 23.22435633524737, "Lymphoproliferative disorder ": 71.89894350936628, "Magnetic resonance imaging abnormal ": 33.4308022293989, "Mean cell haemoglobin decreased ": 44.057680901303655, "Meningitis tuberculous ": 85.5928231358192, "Meningitis viral ": 19.08377803895416, "Microsporidia infection ": 265.35095102493494, "Monocyte count decreased ": 21.62742227465071, "Monocyte percentage increased ": 86.31492287084673, "Mucormycosis ": 10.685504653851993, "Mucosal inflammation ": 22.0039540849673, "Multiple organ dysfunction syndrome ": 9.396115394781216, "Multiple sclerosis ": 3.0084014570127406, "Multiple sclerosis relapse ": 14.41758214973277, "Mycobacterium kansasii infection ": 121.30209803279804, "Nephropathy toxic ": 2.191080728615165, "Neutropenia ": 2.770013540322416, "Neutrophil count increased ": 4.250546417397724, "Neutrophil percentage increased ": 27.769461020411832, "Nitrite urine present ": 97.54135168891756, "Nocardiosis ": 17.762404934025476, "Norovirus infection ": 72.61635787511798, "Nystagmus ": 2.6019176531375776, "Odynophagia ": 5.735476573627094, "Off label use ": 4.53368741691868, "Optic neuritis ": 3.10922594352912, "Oral herpes ": 2.250134324863444, "Organising pneumonia ": 4.291803685718118, "Pancytopenia ": 5.134437082651225, "Parainfluenzae virus infection ": 16.16767691459181, "Paresis ": 3.688983128231283, "Paronychia ": 8.34648148828121, "Pathogen resistance ": 14.311673228735405, "Pericardial effusion ": 2.9760253923020445, "Pneumocystis jirovecii pneumonia ": 10.72556943342062, "Pneumonia adenoviral ": 333.0077595131308, "Pneumonia cytomegaloviral ": 66.76792862072492, "Pneumonia respiratory syncytial viral ": 28.485077342419917, "Pneumonitis ": 5.265153621638745, "Polyomavirus viraemia ": 138.43621350133128, "Post transplant lymphoproliferative disorder ": 85.15263786883847, "Posterior reversible encephalopathy syndrome ": 5.29562500507369, "Product use in unapproved indication ": 4.414279218738303, "Progressive multifocal leukoencephalopathy ": 58.48425720886843, "Pseudomonal sepsis ": 14.667354594778637, "Pseudomonas infection ": 15.67225481119778, "Pulmonary alveolar haemorrhage ": 6.253437234597988, "Pulmonary haemorrhage ": 9.235347963653105, "Red blood cells urine positive ": 46.69188677116886, "Red cell distribution width increased ": 8.389569900968965, "Respiratory disorder ": 3.144984331877096, "Respiratory failure ": 3.969103482953472, "Respiratory syncytial virus infection ": 4.223329983070455, "Rhinovirus infection ": 7.300187238670862, "Richter's syndrome ": 34.21538925188337, "Sarcoidosis ": 3.3277434525972134, "Sepsis ": 5.11287239826322, "Septic shock ": 3.62869809447934, "Serum ferritin increased ": 3.024994164257086, "Sinus bradycardia ": 2.257763818856616, "Skin mass ": 3.74788859673578, "Staphylococcal bacteraemia ": 25.222769160984303, "Staphylococcal infection ": 4.960666192034022, "Stem cell transplant ": 24.66516696859416, "Systemic candida ": 11.10772666084696, "Therapeutic response decreased ": 2.1095828872050557, "Therapy partial responder ": 5.031594306155249, "Thrombotic microangiopathy ": 15.695086587954654, "Transplant dysfunction ": 23.97433169331449, "Transplant failure ": 111.03563885862272, "Transplant rejection ": 51.53554269419166, "Urinary sediment present ": 188.00131186300544, "Urinary tract infection bacterial ": 15.84611562356006, "Urine abnormality ": 25.74766403219155, "Urine analysis abnormal ": 10.254663385925566, "Urine ketone body present ": 19.65047433777163, "Varicella ": 2.6012099944001474, "Varicella zoster virus infection ": 32.53639145212722, "Vascular device infection ": 8.127834469277639, "Venoocclusive disease ": 64.02644450136266, "Venoocclusive liver disease ": 27.41478251505784, "Viraemia ": 102.06373233725432, "Viral haemorrhagic cystitis ": 25.892772364661948, "Viral infection ": 2.633146529383555, "White blood cells urine positive ": 37.20566405736726} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/470.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/470.json new file mode 100644 index 00000000000..23bf7e96d47 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/470.json @@ -0,0 +1 @@ +{"Seizure ": 20.686666023072323} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/471.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/471.json new file mode 100644 index 00000000000..a0b9265a816 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/471.json @@ -0,0 +1 @@ +{"Drug ineffective ": 3.552018041754844, "Hereditary angioedema ": 243.83730034031265} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/472.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/472.json new file mode 100644 index 00000000000..9cccc0e7b42 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/472.json @@ -0,0 +1 @@ +{"Abdominal pain upper ": 2.1604485574137917, "Acute respiratory failure ": 5.756416375761702, "Anosmia ": 2.156678766324315, "Aphasia ": 2.173363708595058, "Aspiration ": 4.75929026938899, "Asthenia ": 2.80691589135434, "Atelectasis ": 3.7577919151614183, "Atrial fibrillation ": 2.549596115594594, "Autoimmune disorder ": 2.866852161161946, "Back disorder ": 3.96975168885958, "Bacteraemia ": 3.888690093487265, "Balance disorder ": 3.278938069832794, "Blood magnesium decreased ": 9.202451250214928, "Blood potassium decreased ": 6.30595620601347, "Blood sodium decreased ": 4.26185594098968, "COVID-19 pneumonia ": 2.835437323855892, "Central venous catheterisation ": 34.560489657803785, "Choking ": 2.9498612247891223, "Concussion ": 8.9172810656474, "Condition aggravated ": 2.3767478608863386, "Dehydration ": 2.9407898179763907, "Diplopia ": 6.9382630421549285, "Diverticulitis ": 3.7990582536834814, "Dysphagia ": 3.64168044297242, "Eye movement disorder ": 5.286820300412947, "Failure to thrive ": 11.745868033030764, "Fall ": 5.475346307178032, "Fear ": 2.305000881015459, "Feeding disorder ": 3.548973781086381, "Feeling abnormal ": 2.816316161144514, "Feeling cold ": 2.938477271034456, "Foot fracture ": 2.887743426747204, "Gait disturbance ": 4.109778868059983, "Gait inability ": 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/479.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/479.json new file mode 100644 index 00000000000..7a10d4ddce7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/479.json @@ -0,0 +1 @@ +{"Asthma ": 42.41947574465548, "Dyspnoea ": 8.057006880484847, "Therapeutic product effect incomplete ": 81.60966613860693} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/48.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/48.json new file mode 100644 index 00000000000..d486eb94bc5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/48.json @@ -0,0 +1 @@ +{"Anxiety ": 5.083037549053048, "Aortic valve stenosis ": 884.2587082422037, "Asthma ": 9.637413100481346, "Atrial fibrillation ": 13.453299975763764, "Benign prostatic hyperplasia ": 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8.501288982942949, "Urinary bladder polyp ": 38.47208248559957, "Urinary incontinence ": 5.962328050010876, "Urine abnormality ": 4.530873981586754, "Urine calcium increased ": 157.2870200041915, "Urine odour abnormal ": 2.8350637743882787, "Urine output increased ": 4.081167707268572, "Uterine prolapse ": 14.07737883444102, "Varicose vein ": 2.6850119467338605, "Vein disorder ": 2.094989132521753, "Vertebroplasty ": 190.75191381203325, "Vertigo ": 4.170485478139744, "Vitamin D decreased ": 9.45027254818665, "Vitamin D increased ": 20.14436392433228, "Weight decreased ": 2.253131953826845, "Weight increased ": 2.7357320590447864, "Wrist fracture ": 11.449877682352518} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/481.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/481.json new file mode 100644 index 00000000000..9e35b77a992 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/481.json @@ -0,0 +1 @@ +{"Blister ": 70.05679981979254, "Erythema ": 20.47093656268918, "Lip erosion ": 4132.516782492467, "Mucosal erosion ": 3630.7298320394366, "Pyrexia ": 3.4385160850659418, "Stevens-Johnson syndrome ": 147.1076537627112, "Thermal burn ": 1213.750854150354} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/482.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/482.json new file mode 100644 index 00000000000..b1f5ca706a1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/482.json @@ -0,0 +1 @@ +{"Anaemia ": 2.5792267260461395, "Diabetes mellitus ": 8.072037215031001, "Diarrhoea ": 3.1447333866357035, "Hypertriglyceridaemia ": 80.38347635221086, "Lipodystrophy acquired ": 94.48533793058571, "Myocardial infarction ": 3.742796175861603, "Neutropenia ": 3.0090889166084143, "Pancreatitis ": 7.360631430953967, "Premature baby ": 15.677764662153026, "Seizure ": 2.604130789549862} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/483.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/483.json new file mode 100644 index 00000000000..4b7ed27af9d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/483.json @@ -0,0 +1 @@ +{"Abnormal loss of weight ": 2.518791676737123, "Acidosis ": 5.369864855215974, "Acquired phimosis ": 381.0232514944572, "Acute kidney injury ": 4.002862802738257, "Anal abscess ": 7.40268720806141, "Aneurysm ruptured ": 12.850542403650108, "Arterial occlusive disease ": 4.753662482475782, "Balanitis candida ": 74.76539324589217, "Balanoposthitis ": 187.3669685846062, "Benign prostatic hyperplasia ": 3.797803918459095, "Bladder cancer ": 2.7807098160331005, "Blood creatine increased ": 12.144871828577896, "Blood creatinine 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": 2.1802354118979985, "Cystitis ": 9.618313294933923, "Cystitis haemorrhagic ": 6.090763236179657, "Dehydration ": 8.24253988309443, "Diabetes mellitus inadequate control ": 5.2130056582385285, "Diabetic coma ": 6.733549963189873, "Diabetic foot ": 7.420458825835947, "Diabetic ketoacidosis ": 54.43984167908836, "Diabetic ketosis ": 103.26586684387912, "Diabetic metabolic decompensation ": 7.778886649909975, "Diabetic neuropathy ": 3.35204112246369, "Dry mouth ": 4.296742544268177, "Dyslipidaemia ": 3.6318232571104634, "Dysuria ": 11.393662912467086, "Emphysematous cystitis ": 77.30325469241441, "Endocarditis ": 3.2046747205024726, "Epididymitis ": 13.382194469434127, "Epigastric discomfort ": 3.3412907780508707, "Erectile dysfunction ": 2.222560341064772, "Escherichia urinary tract infection ": 20.797468515968166, "Euglycaemic diabetic ketoacidosis ": 90.34910364123796, "Extremity necrosis ": 8.039995467351243, "Flank pain ": 4.178131263543519, "Flatulence ": 2.0038485941245545, "Fluid intake reduced ": 8.884714581426127, "Fournier's gangrene ": 83.95445172046969, "Fungal infection ": 21.74862464924447, "Furuncle ": 3.018185129630537, "Gangrene ": 6.784016523611853, "Gastroenteritis ": 2.783675872716062, "Genital burning sensation ": 27.206930303027928, "Genital candidiasis ": 78.82024705584077, "Genital discomfort ": 33.901066116527474, "Genital erythema ": 42.676746027912806, "Genital infection ": 145.0537804183924, "Genital infection female ": 309.191941329436, "Genital infection fungal ": 81.01304316088434, "Genital infection male ": 254.8328181873844, "Genital pain ": 9.760304600112203, "Genital rash ": 27.029737906590864, "Genital swelling ": 45.59450032021551, "Genital tract inflammation ": 67.08217086896731, "Genitourinary tract infection ": 82.0181039857135, "Glomerular filtration rate abnormal ": 6.56700836661905, "Glomerular filtration rate decreased ": 40.43731938826015, "Glucose urine present ": 51.36101939593361, "Glycosuria ": 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"Penile erythema ": 47.41690754376895, "Penile pain ": 9.46494293104424, "Penis disorder ": 15.460999022848425, "Perineal abscess ": 59.45241731900098, "Peripheral arterial occlusive disease ": 3.6371742611429374, "Phimosis ": 81.24626573227967, "Physical deconditioning ": 2.2544684170706257, "Pollakiuria ": 19.0907632991636, "Polycythaemia ": 19.174419530142018, "Polydipsia ": 10.307484050938182, "Polyuria ": 34.11144886349959, "Prerenal failure ": 11.208260245431289, "Prostatitis ": 38.072872679888285, "Pruritus genital ": 85.30780393204091, "Pyelonephritis ": 36.509121217540105, "Pyelonephritis acute ": 59.45778427360257, "Pyelonephritis chronic ": 49.51964846722398, "Pyuria ": 11.562380839500122, "Renal abscess ": 17.583193771631024, "Renal colic ": 4.7761402664022725, "Renal cyst ": 2.1802354118979985, "Renal disorder ": 2.231413556772083, "Renal function test abnormal ": 3.1404216714216275, "Renal impairment ": 3.477573718945655, "Renal pain ": 2.497374721450217, "Retinopathy ": 3.371922198659732, "Sepsis ": 2.1369484547088144, "Skin fissures ": 2.224156203732873, "Systemic candida ": 6.997512362771251, "Therapy cessation ": 5.789759683461301, "Thirst ": 11.70840791392076, "Thrombotic cerebral infarction ": 43.483268509844834, "Toe amputation ": 25.99462519736602, "Type 2 diabetes mellitus ": 3.123563045580182, "Underdose ": 2.51625728458078, "Urethritis ": 42.50346171480211, "Urinary incontinence ": 4.582217489823612, "Urinary retention ": 2.137579875037405, "Urinary tract disorder ": 4.379137090374609, "Urinary tract infection ": 24.06163086509158, "Urinary tract infection bacterial ": 13.725104036814848, "Urinary tract infection fungal ": 86.12694751725085, "Urine abnormality ": 7.188746573197485, "Urine analysis abnormal ": 13.100425612770389, "Urine ketone body present ": 60.20756411542976, "Urine odour abnormal ": 10.759014790669577, "Urine output decreased ": 2.70738106831247, "Urine output increased ": 13.545877315322372, "Urosepsis ": 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/485.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/485.json new file mode 100644 index 00000000000..ea040a0f6d9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/485.json @@ -0,0 +1 @@ +{"Osteonecrosis of jaw ": 240.23676751424856} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/486.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/486.json new file mode 100644 index 00000000000..6f0a2600d10 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/486.json @@ -0,0 +1 @@ +{"Asthenia ": 2.8253715454656567, "Blood pressure increased ": 5.482675094782659, "Decreased appetite ": 4.7920367431162, "Dehydration ": 5.536733083882675, "Diarrhoea ": 3.849154145997309, "Disease progression ": 14.195170977663262, "Dysphonia ": 16.328775921289758, "Haemoglobin decreased ": 3.209095355534594, "Hospitalisation ": 4.123921254698673, "Hypertension ": 5.738788442464368, "Hypertensive crisis ": 15.13123134719624, "Hypothyroidism ": 9.370291237474746, "Intestinal perforation ": 25.87302839628541, "Lethargy ": 2.8195867854336782, "Malignant neoplasm progression ": 4.415054407236185, "Mucosal inflammation ": 15.17872435955698, "Palmar-plantar erythrodysaesthesia syndrome ": 21.99549428320448, "Pleural effusion ": 4.489202604559692, "Posterior reversible encephalopathy syndrome ": 27.495954427717464, "Product dose omission issue ": 2.777737073257769, "Stomatitis ": 5.376051162405831, "Urinary tract infection ": 3.483635647762165} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/487.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/487.json new file mode 100644 index 00000000000..ec3f1db1859 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/487.json @@ -0,0 +1 @@ +{"Drug ineffective ": 4.000329467768764} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/488.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/488.json new file mode 100644 index 00000000000..abcc4f8564a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/488.json @@ -0,0 +1 @@ +{"Acquired gene mutation ": 15.66309242300454, "Alopecia ": 2.609580771734368, "Anaemia ": 2.423286621719629, "Ascites ": 2.5619762736121907, "Aspartate aminotransferase increased ": 2.349733571990744, "Blood alkaline phosphatase increased ": 2.154862427453137, "Body height decreased ": 4.470140625322871, "Bone cancer ": 13.85700191686983, "Bone disorder ": 4.578510109014138, "Bone lesion ": 33.43844664110897, "Bone pain ": 3.261699810429383, "Breast cancer ": 12.554780723963908, "Breast cancer metastatic ": 111.6333709849885, "Breast cancer recurrent ": 53.30427663977488, "Breast discharge ": 21.601470772894395, "Carbohydrate antigen 15-3 increased ": 167.92569400882076, "Carcinoembryonic antigen increased ": 45.54556704109553, "Cardiomegaly ": 2.881611804439055, "Cytopenia ": 4.135166399868111, "Decreased immune responsiveness ": 20.96056018690132, "Disease progression ": 4.453659987427071, "Dry skin ": 3.1249402598627363, "Eructation ": 3.427008741726635, "Feeding disorder ": 2.369856892883748, "Full blood count abnormal ": 2.3037884716534367, "Full blood count decreased ": 3.764609736582575, "Glomerular filtration rate decreased ": 2.3858953826322846, "Granulocytopenia ": 5.26642854822267, "Haematocrit decreased ": 4.667494169906409, "Haematotoxicity ": 9.399724061338697, "Haemoglobin decreased ": 2.3343048956768078, "Hepatic failure ": 2.0136392652279995, "Hepatic lesion ": 9.348119059420426, "Hepatotoxicity ": 10.44203837597922, "Hormone receptor positive HER2 negative 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": 45.354334178589305, "Metastases to the mediastinum ": 49.8933315420318, "Metastases to thorax ": 182.33121832079317, "Metastasis ": 23.47502587778088, "Metastatic neoplasm ": 12.260579057756733, "Mucosal inflammation ": 4.880115684873705, "Musculoskeletal discomfort ": 3.443028425450144, "Myelosuppression ": 2.101981274351814, "Neoplasm progression ": 27.262878949959, "Neutropenia ": 21.21152773278048, "Neutrophil count decreased ": 7.108391500316962, "Nodule ": 2.2788997650081018, "Osteolysis ": 16.755677717001202, "Osteonecrosis of jaw ": 10.949193842622188, "Osteosclerosis ": 28.43729889478194, "PIK3CA-activated mutation ": 127.98164662635736, "Platelet count decreased ": 2.758389019864369, "Platelet count increased ": 2.1715958955811145, "Pleural effusion ": 4.109089641700626, "Pneumonitis ": 2.8620424005194227, "Product dose omission in error ": 6.374283779589493, "Pulmonary mass ": 5.03761006940257, "Red blood cell count decreased ": 4.046474150677802, "Second primary malignancy ": 2.633145386339633, "Spinal pain ": 5.987144827668145, "Staphylococcal infection ": 2.4473078309516287, "Therapy partial responder ": 9.39073316115756, "Thrombocytopenia ": 3.1474728457384846, "Thrombophlebitis ": 5.551954059874265, "Tooth fracture ": 3.3563262451346207, "Transaminases increased ": 2.5598138979098537, "Tumour marker increased ": 54.70990257553316, "White blood cell count decreased ": 4.07136591133085} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/489.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/489.json new file mode 100644 index 00000000000..38ca64d5f89 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/489.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 11.460503571753144, "Aspartate aminotransferase increased ": 10.08115173824039, "Cholestasis ": 30.52912981358692, "Granulomatous liver disease ": 906.3244014727634, "Hepatic encephalopathy ": 61.340033465269, "Hepatitis fulminant ": 196.6941678065769, "Immune reconstitution inflammatory syndrome ": 122.55659360463837, "Insomnia ": 4.998444574232191, "Jaundice ": 13.111238054977, "Leukopenia ": 6.816101975563304, "Lymphopenia ": 42.21135955493028, "Neutropenia ": 3.100126465937859, "Pneumonia ": 2.4793974479225422, "Renal failure ": 4.777526412678703, "Tachypnoea ": 34.84183565777153, "Tuberculosis liver ": 7613.25089238314} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/49.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/49.json new file mode 100644 index 00000000000..42b49e3c010 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/49.json @@ -0,0 +1 @@ +{"Respiratory failure ": 27.31797610905545} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/490.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/490.json new file mode 100644 index 00000000000..aa6f860f511 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/490.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 6.167782667245704, "Accidental overdose ": 3.253932905014447, "Acute pulmonary oedema ": 7.313833577725554, "Aggression ": 54.633926663663935, "Agitation ": 6.742071344111657, "Altered state of consciousness ": 5.8775045454376045, "Amnesia ": 2.469953105065148, "Anger ": 25.77277814290632, "Anticonvulsant drug level increased ": 37.00809436042189, "Apathy ": 4.520259805327356, "Ataxia ": 14.899451907782906, "Aura ": 22.55356930889413, "Balance disorder ": 6.42614955601004, "Behaviour disorder ": 12.374557642448412, "Cognitive disorder ": 5.50257768510383, "Confusional state ": 2.0225248441151784, "Crying ": 3.5104329365665867, "Delirium ": 2.337125726675548, "Delusion ": 10.619229147939722, "Depressed mood ": 3.606328785464148, "Depression ": 2.5250618784263463, "Diplopia ": 5.439592715976101, "Disturbance in attention ": 2.109607166475475, "Drug eruption ": 4.319073140031302, "Drug interaction ": 3.9101719069636114, "Drug level decreased ": 11.044919091057174, "Drug withdrawal convulsions ": 30.46257916292862, "Drug-induced liver injury ": 4.540196246850226, "Dysarthria ": 7.500747393907536, "Dyskinesia ": 3.749273033091782, "Emotional disorder ": 3.707431638699628, "Encephalopathy ": 2.860885076501177, "Epilepsy ": 9.16621615839612, "Erectile dysfunction ": 4.650333661325357, "Euphoric mood ": 12.61722814648986, "Exfoliative rash ": 17.966812824868196, "Exposure during pregnancy ": 2.960218242025225, "Fall ": 3.088240962111503, "Focal dyscognitive seizures ": 64.32892925188159, "Gait disturbance ": 5.531031494229634, "Gaze palsy ": 27.749640592152737, "General physical health deterioration ": 3.4681400779768103, "Generalised tonic-clonic seizure ": 5.354562078945678, "Hallucination ": 3.0691786676542123, "Hallucination, auditory ": 5.23944941306573, "Hallucination, visual ": 6.176800216476574, "Head injury ": 6.676504151030104, "Heart rate irregular ": 3.795845124338, "Hepatic cytolysis ": 2.4883904648832336, "Homicidal ideation ": 58.91360866932415, "Hostility ": 23.94001159076202, "Hyperammonaemia ": 8.345077691863196, "Hypersomnia ": 2.383497799806398, "Hypothermia ": 11.451326894691636, "Hypotonia ": 2.877735763930547, "Increased appetite ": 4.068681134055331, "Intentional overdose ": 6.698387422911089, "Irritability ": 23.393412907221617, "Liver injury ": 3.229319690224901, "Mental status changes ": 2.8803371331903262, "Mitral valve disease ": 34.563785348141884, "Mood altered ": 12.627323155305202, "Multiple-drug resistance ": 81.50660345662867, "Nervousness ": 2.674890638713748, "Paranoia ": 5.685450323534483, "Partial seizures ": 23.135567874753814, "Persecutory delusion ": 17.46253025377572, "Personality change ": 13.786134240113562, "Petit mal epilepsy ": 9.475416310747857, "Physical assault ": 70.48429610073784, "Pneumonia aspiration ": 5.604614723136496, "Product administered to patient of inappropriate age ": 6.763873098312874, "Psychiatric symptom ": 8.522408418008784, "Psychomotor hyperactivity ": 4.176428754160562, "Psychotic disorder ": 16.435413817933814, "Restlessness ": 5.022740264063131, "Salivary hypersecretion ": 4.646227622764214, "Sedation ": 2.2902415693451306, "Seizure ": 9.315850743240084, "Self-destructive behaviour ": 9.94347716623241, "Skin lesion ": 2.007819986359565, "Slow speech ": 33.280715340706934, "Somnolence ": 6.647284504299689, "Staphylococcus test positive ": 30.773475985095885, "Status epilepticus ": 26.01142895891065, "Sudden unexplained death in epilepsy ": 107.67430235135168, "Suicidal ideation ": 8.418510214846759, "Suicide attempt ": 12.30075627524149, "Toxic epidermal necrolysis ": 5.53517838660358, "Urinary retention ": 2.9912568767672965, "Vertigo ": 4.485276549107328, "Weight increased ": 3.709066018644176, "Wrong patient received product ": 17.40906569057788} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/491.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/491.json new file mode 100644 index 00000000000..8305d1693ff --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/491.json @@ -0,0 +1 @@ +{"Adverse event ": 4.02219839339429, "Atrial fibrillation ": 2.555762416166219, "Cardiac disorder ": 4.501018091845299, "Cerebrovascular accident ": 4.285712575350503, "Depressed mood ": 2.050213171226122, "Depression ": 2.416578072400478, "Dyspepsia ": 2.408050438087031, "Flatulence ": 3.172138014361128, "Gastrointestinal disorder ": 2.9483016541245406, "Glomerular filtration rate decreased ": 21.12201785750508, "Hospitalisation ": 3.4804074557423306, "Impaired work ability ": 5.213511559014525, "Implantable defibrillator insertion ": 95.1580602402994, "Inappropriate schedule of product administration ": 4.172117018832758, "Nasal congestion ": 2.8220767946630883, "Nephrolithiasis ": 4.086792359180077, "Neuropathy peripheral ": 4.080738861899907, "Poor quality sleep ": 11.020034157197278, "Pre-existing condition improved ": 171.6906000939662, "Product dose omission in error ": 44.89261774555358, "Product dose omission issue ": 13.547254056044514, "Product physical issue ": 22.632470588815448, "Proteinuria ": 10.428904441011738, "Renal disorder ": 2.878488758846533, "Renal impairment ": 3.52735308160889, "Rhinorrhoea ": 5.519666429598175, "Sinusitis ": 2.801534104790178, "Surgery ": 4.916651430912984, "Temperature intolerance ": 21.084889731617096, "Transient ischaemic attack ": 5.38140934991934, "Weight increased ": 2.4688031127314165, "Wrong technique in product usage process ": 2.434036577458104} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/492.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/492.json new file mode 100644 index 00000000000..fb931a2f7c6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/492.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.431940454828467, "Abdominal pain upper ": 2.3898946325210093, "Alanine aminotransferase increased ": 4.270871736889416, "Amylase increased ": 22.13792651303727, "Angioedema ": 3.2202998347327254, "Anuria ": 3.4153728605027305, "Aspartate aminotransferase increased ": 4.082101635048918, "Blister ": 3.795626199092832, "Blood alkaline phosphatase increased ": 2.6738826119177266, "Blood bilirubin increased ": 2.4439085118506894, "Blood cholesterol increased ": 2.0093432894038763, "Blood glucose abnormal ": 4.378626138673745, "Blood glucose decreased ": 2.4125704585516154, "Blood glucose fluctuation ": 7.83069628745645, "Blood glucose increased ": 12.042865731722754, "Blood triglycerides increased ": 5.639325784012208, "Blood urea increased ": 3.420815113803165, "Cardiac failure ": 3.016822651236728, "Cataract ": 2.306374864559677, "Cholelithiasis ": 7.085289593069954, "Cholestasis ": 5.328536015386185, "Chromaturia ": 2.939282431119877, "Dermatitis bullous ": 23.051075740275486, "Diabetes mellitus ": 5.565848531106048, "Diabetes mellitus inadequate control ": 9.686584580573502, "Dry throat ": 5.06631974949236, "Dysphagia ": 2.18326425019801, "Eczema ": 4.109838102645774, "Encephalopathy ": 2.8150101306743283, "Face oedema ": 2.042691965661161, "Fall ": 2.666869653173653, "Fear ": 2.968450015096424, "Femur fracture ": 4.537199751920985, "Gait inability ": 2.101608930772624, "Gamma-glutamyltransferase increased ": 8.293864592374037, "Gastritis ": 2.2698036122980376, "Generalised oedema ": 3.4019329067955275, "Glycosylated haemoglobin increased ": 13.7917851740662, "Hepatic cytolysis ": 5.882952060704632, "Hepatic steatosis ": 9.965332850329574, "Hepatitis ": 3.419609152059509, "Hyperglycaemia ": 3.7372087191152663, "Hypertension ": 2.0966598540794985, "Hypoglycaemia ": 6.824173978957802, "Hypoglycaemic coma ": 2.7076728133784727, "Incorrect dose administered ": 2.523397623914536, "Jaundice ": 5.058606614424945, "Lactic acidosis ": 2.8842817085669443, "Limb injury ": 2.77480984054728, "Lipase increased ": 26.78752759263563, "Liver function test abnormal ": 2.3870294615828054, "Lower limb fracture ": 3.3910265893179345, "Oedema peripheral ": 2.801378047410939, "Osteoarthritis ": 2.8716166591156584, "Pancreatic carcinoma ": 4.494502709009152, "Pancreatitis ": 9.407410761028077, "Pancreatitis acute ": 13.386847840851493, "Pemphigoid ": 91.6266499843558, "Pruritus ": 2.091835421999153, "Pulmonary oedema ": 2.320313057417405, "Renal disorder ": 3.578620797460533, "Skin exfoliation ": 3.789127149376613, "Transaminases increased ": 4.6432241461890085} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/493.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/493.json new file mode 100644 index 00000000000..7cc7aaa21f3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/493.json @@ -0,0 +1 @@ +{"Acute graft versus host disease ": 8.473399684785521, "Acute kidney injury ": 2.913212315839871, "Acute respiratory distress syndrome ": 6.5106134136318365, "Agranulocytosis ": 4.13365249352052, "Aspergillus infection ": 6.04004687555517, "Bone marrow failure ": 13.67011843057223, "Bronchiectasis ": 6.120267609181379, "Bronchopulmonary aspergillosis ": 18.756910583858662, "Cardiogenic shock ": 3.7547533692140367, "Cholestasis ": 2.407620749303092, "Clostridium difficile colitis ": 4.737792072897808, "Coagulopathy ": 2.730106209427165, "Colitis ": 2.268487688612998, "Condition aggravated ": 2.089118306521664, "Cytomegalovirus chorioretinitis ": 149.11839336348416, "Cytomegalovirus colitis ": 163.57203200345444, "Cytomegalovirus enteritis ": 140.93962494464978, "Cytomegalovirus enterocolitis ": 49.528379822420405, "Cytomegalovirus gastritis ": 168.0671433188008, "Cytomegalovirus hepatitis ": 132.7945815142211, "Cytomegalovirus infection ": 60.69375850001629, "Cytomegalovirus infection reactivation ": 86.31765211281565, "Cytomegalovirus syndrome ": 473.6931449373272, "Cytomegalovirus test positive ": 14.490029374334371, "Cytomegalovirus viraemia ": 174.12577136506067, "Cytopenia ": 15.098563552720655, "Depressed level of consciousness ": 3.6070946670252138, "Disseminated cytomegaloviral infection ": 406.71840639623866, "Drug ineffective ": 3.0927815298781858, "Drug ineffective for unapproved indication ": 8.909125511865607, "Drug reaction with eosinophilia and systemic symptoms ": 4.233421784225564, "Drug resistance ": 64.03121628065877, "Encephalitis cytomegalovirus ": 342.37811265980645, "Encephalopathy ": 3.9401389606454673, "Enterococcal infection ": 15.854964432961388, "Epiretinal membrane ": 81.73674680202016, "Febrile neutropenia ": 2.5514577489793666, "Fungal infection ": 7.120198380440874, "Fusarium infection ": 109.73097073532917, "Genital lesion ": 70.14313202692853, "Graft versus host disease ": 25.46792910769731, "Graft versus host disease in gastrointestinal tract ": 19.20732665701491, "Granulocytopenia ": 8.082643050731505, "Haemodynamic instability ": 6.7532442981957965, "Haemophagocytic lymphohistiocytosis ": 19.533609795889223, "Hepatic function abnormal ": 3.481567379843093, "Hepatitis cholestatic ": 3.1528992255001183, "Hepatomegaly ": 3.848120487977617, "Hyperpyrexia ": 2.218929768062478, "Hypomagnesaemia ": 4.873743236638839, "Hypoxia ": 4.639274883002148, "Immune reconstitution inflammatory syndrome ": 9.737013362436642, "Immune thrombocytopenia ": 2.686042786103918, "Intentional product use issue ": 4.597188256118383, "Kidney fibrosis ": 28.75917029524525, "Klebsiella bacteraemia ": 56.73331181658339, "Large intestinal ulcer ": 18.840331831147857, "Leukopenia ": 11.184021713047224, "Liver disorder ": 2.380944135646563, "Lung infiltration ": 4.149060361502943, "Lung opacity ": 8.68872095946977, "Lymphopenia ": 3.5224167646458038, "Metabolic acidosis ": 4.5232319866114725, "Multiple organ dysfunction syndrome ": 11.93025485977306, "Myelosuppression ": 8.681818500258082, "Nephropathy toxic ": 17.35222385259939, "Nephrotic syndrome ": 3.5443542776729555, "Neutropenia ": 7.344611275963463, "Neutrophil Pelger-Huet anomaly present ": 559.0386598035703, "Neutrophil count decreased ": 3.433080153205167, "Off label use ": 4.540881651885303, "Oliguria ": 6.232025790696159, "Oral candidiasis ": 5.375922212651754, "Oxygen saturation decreased ": 2.1666263893054003, "Pancytopenia ": 15.183086190392933, "Pathogen resistance ": 80.30511535194721, "Platelet count decreased ": 2.7301707796880685, "Pneumocystis jirovecii pneumonia ": 17.951250688834016, "Pneumonia bacterial ": 5.285561322354974, "Pneumonia cytomegaloviral ": 96.60966432325596, "Pneumonia fungal ": 19.1127906397976, "Pneumonia lipoid ": 261.0318101212616, "Pneumonia necrotising ": 138.39174146074512, "Post transplant lymphoproliferative disorder ": 27.977122528355924, "Product use in unapproved indication ": 8.146975844656072, "Product use issue ": 12.993841760372671, "Pseudomonas infection ": 12.41252544005707, "Pulmonary hypertension ": 2.3506556572309822, "Renal disorder ": 2.987806319402204, "Renal failure ": 2.20535036530226, "Renal impairment ": 3.130888841537896, "Respiratory failure ": 8.32679428686274, "Retinal degeneration ": 36.80243120887074, "Retinal detachment ": 15.433064259091855, "Retinitis ": 56.1019253052003, "Sepsis ": 4.403691767137607, "Septic shock ": 7.811146700237906, "Shock ": 4.025557232934711, "Staphylococcal infection ": 3.48373986014909, "Systemic mycosis ": 27.389445312530945, "Tachypnoea ": 3.407427283195473, "Thrombocytopenia ": 7.6902376100854015, "Thrombotic microangiopathy ": 57.91471253342652, "Transplant dysfunction ": 32.831780158127145, "Transplant rejection ": 52.58484420039505, "Tubulointerstitial nephritis ": 3.3693175426411206, "Viral load increased ": 15.384479018341914, "Viral mutation identified ": 35.3663445773665, "White blood cell count decreased ": 4.441414615500608} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/494.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/494.json new file mode 100644 index 00000000000..5af3b3da5a8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/494.json @@ -0,0 +1 @@ +{"Ovarian hyperstimulation syndrome ": 2008.8510980136048} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/495.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/495.json new file mode 100644 index 00000000000..8dbf7248848 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/495.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.184502074062689, "Abdominal pain lower ": 3.4012786098137373, "Abnormal loss of weight ": 2.2635609413244744, "Abortion induced ": 11.804580931956572, "Abortion missed ": 3.5810030082947564, "Abortion spontaneous ": 4.204782983496123, "Acne ": 4.271315468787484, "Acute disseminated encephalomyelitis ": 22.16354484870209, "Acute sinusitis ": 5.391267294317867, "Adenocarcinoma of the cervix ": 54.1932788499651, "Adverse event ": 3.220604709138017, "Adverse event following immunisation ": 25.915461537995174, "Alcohol intolerance ": 3.997143694867675, "Allergy to animal ": 5.06044881761342, "Allergy to vaccine ": 11.178778725263795, "Allodynia ": 8.299626783196151, "Alopecia areata ": 2.779844396609774, "Amniotic cavity infection ": 4.142644689710695, "Amplified musculoskeletal pain syndrome ": 145.51225347647076, "Amyotrophic lateral sclerosis ": 2.941585496084374, "Angiopathy ": 3.550093183006948, "Anogenital warts ": 72.65606894254631, "Anorexia nervosa ": 10.72942061592284, "Anti-thyroid antibody ": 18.15384972895468, "Anti-thyroid antibody positive ": 4.171913179417255, "Antibody test negative ": 4.818781612933058, "Antinuclear antibody positive ": 3.7864937317592338, "Antiphospholipid syndrome ": 6.271562033230672, "Anxiety disorder ": 3.542877015599678, "Anxiety disorder due to a general medical condition ": 52.9345240341982, "Appendicectomy ": 6.2699308076641325, "Areflexia ": 4.340270932646788, "Arnold-Chiari malformation ": 4.486955127273264, "Arrested labour ": 17.059728529030046, "Arthritis reactive ": 4.487941083354287, "Asthma exercise induced ": 30.20561878252772, "Astigmatism ": 2.9041705346459343, "Ataxia ": 2.372710911892667, "Atonic seizures ": 3.1818444584995884, "Attention deficit hyperactivity disorder ": 4.851267571153799, "Autoimmune disorder ": 9.804258908793251, "Autoimmune encephalopathy ": 27.682357980940907, "Autoimmune neuropathy ": 15.68810972734583, "Autoimmune thyroiditis ": 6.604799007513588, "Autonomic nervous system imbalance ": 31.91917461103637, "Autonomic neuropathy ": 23.450875887580985, "Bacterial vaginosis ": 5.636362887135623, "Bacterial vulvovaginitis ": 18.941074702803203, "Bartonellosis ": 79.02833825866827, "Bedridden ": 2.327442938541424, "Beta haemolytic streptococcal infection ": 6.578791146617865, "Blindness transient ": 3.7372711912742287, "Blood aluminium increased ": 27.869754761488355, "Blood glucose normal ": 46.021967412803335, "Blood test ": 5.465525774160485, "Blood urea decreased ": 2.9716137295692797, "Body temperature fluctuation ": 4.574679359891302, "Bone tuberculosis ": 10.29040971684035, "Borderline personality disorder ": 8.0695702875848, "Breast discharge ": 4.038560196684616, "Breech presentation ": 11.104111477924382, "Bronchial hyperreactivity ": 2.169827093298637, "Bruxism ": 2.714721268938394, "Caesarean section ": 2.726917553068876, "Carbon dioxide decreased ": 3.3159886533305967, "Carcinoma in situ ": 46.591445822586, "Cataplexy ": 24.5973379204542, "Central nervous system inflammation ": 9.508103438573952, "Central nervous system vasculitis ": 3.7601409626398254, "Cerebellar ataxia ": 3.200512348781104, "Cerebral circulatory failure ": 46.8022731247579, "Cervical conisation ": 240.088482691558, "Cervical dysplasia ": 222.5649834247455, "Cervicitis ": 20.396950832593944, "Cervicobrachial syndrome ": 3.1818444584995884, "Cervix carcinoma ": 25.623608003271865, "Cervix carcinoma stage 0 ": 171.54689905781538, "Cervix disorder ": 21.18155176500074, "Chorea ": 2.1317744436119708, "Chronic fatigue syndrome ": 16.984119810590094, "Chronic inflammatory demyelinating polyradiculoneuropathy ": 2.72362327558573, "Circadian rhythm sleep disorder ": 6.40968737843045, "Clonic convulsion ": 2.81011381527032, "Clonus ": 3.666290331002765, "Cognitive disorder ": 4.309543260610299, "Cold sweat ": 2.122695767082145, "Complex regional pain syndrome ": 24.36070927443529, "Complication of delivery ": 25.68297293376917, "Computerised tomogram normal ": 47.5232163302004, "Concussion ": 7.596917342288229, "Connective tissue disorder ": 7.184985016512057, "Consciousness fluctuating ": 2.911629417832572, "Conversion disorder ": 21.537297112312565, "Coxsackie viral infection ": 24.228647034438715, "Culture urine positive ": 6.300343591545618, "Cystitis interstitial ": 3.785367848051517, "Dairy intolerance ": 13.313539013643542, "Decreased activity ": 2.321012922317694, "Decreased immune responsiveness ": 2.943925815988416, "Demyelination ": 11.827197393323337, "Derealisation ": 2.5345590122725574, "Dermal cyst ": 2.9716137295692797, "Dermatomyositis ": 2.425912937723406, "Diplegia ": 7.928637210571082, "Diplopia ": 2.1760861979223804, "Dissociative disorder ": 9.51126433642105, "Disturbance in attention ": 4.567871360238483, "Dizziness ": 2.31921778540995, "Dizziness postural ": 2.8182796627603803, "Drooling ": 2.0679736900465224, "Drowning ": 3.357622485606285, "Drug exposure before pregnancy ": 5.386528222966223, "Dysaesthesia ": 3.5214856124315714, "Dyskinesia ": 5.982727196062557, "Dyspareunia ": 10.603316960373816, "Dysplasia ": 7.573681381639845, "Dysstasia ": 2.2114067362863983, "Dysuria ": 2.680385824809301, "Ectopic pregnancy ": 2.4706034617320998, "Ehlers-Danlos syndrome ": 72.2150223153652, "Electrocardiogram T wave abnormal ": 6.768431223725661, "Encephalitis ": 6.225442000031031, "Encephalitis autoimmune ": 5.243879314143949, "Encephalitis post immunisation ": 25.140718493747272, "Encephalitis viral ": 2.555811670245405, "Encephalomyelitis ": 11.833981075332511, "Endometriosis ": 7.821178586733486, "Eosinophilic oesophagitis ": 9.935904510541976, "Epilepsy ": 2.526118706123407, "Epstein-Barr virus infection ": 3.587175413086636, "Erythema nodosum ": 3.046760942743399, "Essential tremor ": 3.599686820589099, "Eustachian tube dysfunction ": 5.684287021508732, "Exercise tolerance decreased ": 4.873134633713202, "Exposure during pregnancy ": 6.714412803950575, "Eye movement disorder ": 10.217407710713417, "Eyelid function disorder ": 4.20169660850503, "Face injury ": 4.792482205430915, "Facial paralysis ": 2.1577155711032687, "Facial paresis ": 3.676057971027796, "Facial spasm ": 3.9651869570284375, "Failed trial of labour ": 88.78244063081932, "Fear of injection ": 2.758993614797749, "Fibroadenoma of breast ": 6.6079039566281255, "Fibromyalgia ": 3.5640499589806574, "Focal dyscognitive seizures ": 2.3153184668312807, "Foetal heart rate abnormal ": 4.446274376300782, "Foetal heart rate deceleration abnormality ": 3.2437543729757685, "Food allergy ": 4.997603417966292, "Food intolerance ": 8.632601510921315, "Full blood count ": 12.471320486033791, "Full blood count normal ": 33.72115178371756, "Gait inability ": 2.527331687040578, "Gastroenteritis ": 2.07822184601995, "Gastrointestinal bacterial overgrowth ": 9.269911676393484, "Gastrointestinal motility disorder ": 2.099541604819133, "Gaze palsy ": 4.161020548772105, "General symptom ": 3.753457570897822, "Generalised anxiety disorder ": 12.27009129444493, "Generalised tonic-clonic seizure ": 3.695166276212011, "Genito-pelvic pain/penetration disorder ": 35.76787976752307, "Gestational hypertension ": 2.809742312328228, "Gluten sensitivity ": 16.407748403799914, "Granuloma ": 2.058729047525755, "Grunting ": 5.4154000492976, "Guillain-Barre syndrome ": 8.890485041552422, "Haemorrhagic ovarian cyst ": 8.90084121236159, "Head injury ": 5.776231490997012, "Henoch-Schonlein purpura ": 6.845010088781863, "Hidradenitis ": 2.876777436521344, "Hirsutism ": 2.257764834363822, "Hodgkin's disease ": 3.678976217053104, "Hormone level abnormal ": 2.360556084434402, "Human papilloma virus test positive ": 658.4496585751372, "Hyperacusis ": 14.740686373023308, "Hyperaesthesia ": 2.4441828976645663, "Hypermetropia ": 3.968422311759035, "Hypermobility syndrome ": 34.5737603775742, "Hypersomnia ": 4.776761134435052, "Hypertonic bladder ": 3.698041584363723, "Hyperventilation ": 10.850281370163048, "Hypoaesthesia ": 2.8673290603280543, "Hyporeflexia ": 4.060867572764426, "Hypotonia ": 2.1086709497718603, "Idiopathic intracranial hypertension ": 4.383536482427187, "Illusion ": 4.387385125561347, "Immediate post-injection reaction ": 62.68624457740534, "Immune system disorder ": 4.16992911048345, "Immune thrombocytopenia ": 2.810102750169865, "Immunodeficiency common variable ": 12.967196997188552, "Immunoglobulin therapy ": 44.90256802070202, "Impaired gastric emptying ": 5.598179826764711, "Impaired work ability ": 3.219887370171268, "Impetigo ": 2.434518211837626, "Inappropriate schedule of product administration ": 3.5903435834293447, "Incomplete course of vaccination ": 4.899971239737133, "Incorrect route of product administration ": 2.1604787777969023, "Increased tendency to bruise ": 3.3752282841523056, "Induration ": 3.849267172718184, "Infection susceptibility increased ": 4.791435754704932, "Infectious mononucleosis ": 21.47945737499857, "Infertility ": 8.486809905560957, "Infertility female ": 7.587488265601696, "Inflammatory bowel disease ": 2.12177509232735, "Initial insomnia ": 2.699538546551396, "Injected limb mobility decreased ": 2.321739191336306, "Injection site irritation ": 3.071041323548865, "Injection site paraesthesia ": 2.2674519405757576, "Insulin resistance ": 2.472983569635918, "Intensive care ": 10.340098354904514, "Iron deficiency ": 2.7022190776147137, "Iron deficiency anaemia ": 2.1084246897166388, "Irritable bowel syndrome ": 2.4528970980124982, "Joint dislocation ": 2.0492379273751333, "Joint hyperextension ": 11.915493764137414, "Joint lock ": 4.4892970446945055, "Joint noise ": 3.4018527997399164, "Juvenile idiopathic arthritis ": 9.383357027318214, "Juvenile myoclonic epilepsy ": 64.7540181829206, "Labour complication ": 66.52434329736816, "Lactose intolerance ": 6.460965124056082, "Laryngeal pain ": 12.417265225085814, "Learning disability ": 2.624044532511292, "Learning disorder ": 2.857511896507905, "Leukoencephalomyelitis ": 132.95789170707545, "Ligament sprain ": 2.636477003373537, "Lip injury ": 5.0152810186693495, "Livedo reticularis ": 3.2144602592322165, "Lordosis ": 8.371365617444159, "Loss of consciousness ": 4.469268674356597, "Loss of control of legs ": 2.9039571759100617, "Lumbar puncture ": 15.272774129780249, "Lupus nephritis ": 2.612345366539917, "Lyme disease ": 10.666414880869382, "Magnetic resonance imaging head abnormal ": 2.2496140464684977, "Major depression ": 2.5541108282856504, "Mast cell activation syndrome ": 19.37366384462523, "Maternal exposure before pregnancy ": 5.572073221524352, "Melanocytic naevus ": 2.052637310544196, "Memory impairment ": 2.820406397776104, "Meningism ": 5.627798572035309, "Meningitis viral ": 3.2392127816267102, "Mesenteric lymphadenitis ": 12.166718115190466, "Metal poisoning ": 21.41090238761431, "Methylenetetrahydrofolate reductase gene mutation ": 132.95789170707545, "Migraine ": 2.355015301968417, "Migraine with aura ": 3.4332702480461625, "Migraine without aura ": 9.275656764706726, "Miller Fisher syndrome ": 4.201598200555135, "Mixed anxiety and depressive disorder ": 2.7332632117912112, "Mixed connective tissue disease ": 10.969720467285828, "Monoparesis ": 3.207761190666808, "Monoplegia ": 5.566736809569423, "Motion sickness ": 4.564294642739241, "Mouth injury ": 2.559722159869604, "Multiple sclerosis ": 7.000328285493678, "Muscle contractions involuntary ": 2.450452707286093, "Muscle contracture ": 2.1030527772341507, "Muscle rigidity ": 2.295670642580961, "Muscle tightness ": 2.9787755721043467, "Muscle twitching ": 3.192684277248285, "Muscular weakness ": 4.461509714841062, "Mycoplasma infection ": 16.890791795422807, "Myelitis ": 5.051379494696148, "Myelitis transverse ": 10.712938448215867, "Myoclonic epilepsy ": 2.0193118932054994, "Myofascial pain syndrome ": 6.330061632747766, "Myofascitis ": 25.647032322582945, "Narcolepsy ": 23.67095228854161, "Neck pain ": 2.330338741475777, "Nervous system disorder ": 2.8370247140589893, "Neurogenic bladder ": 4.093308835175206, "Neurological symptom ": 2.9425877240799285, "Neuromyelitis optica spectrum disorder ": 5.663523013688188, "Neuromyopathy ": 2.4396592543916027, "No adverse event ": 3.887933854760525, "Noninfective encephalitis ": 7.371081007566778, "Nystagmus ": 2.010269425713638, "Obsessive-compulsive disorder ": 2.858695349858913, "Opisthotonus ": 2.504018289459586, "Optic neuritis ": 6.166319942328212, "Orthostatic intolerance ": 108.22267915678968, "Otitis externa ": 3.267371003436215, "Otitis media acute ": 6.424575725180661, "Ovarian cyst ": 7.271329271376039, "Ovarian cyst ruptured ": 9.585506318345404, "Ovarian failure ": 17.649250192178776, "Pallor ": 9.188264992769335, "Papilloma viral infection ": 136.76112806333907, "Paralysis ": 6.948879687817077, "Paraparesis ": 60.87283161650386, "Paraplegia ": 2.8724471925193984, "Paresis ": 4.392160465170734, "Pelvic inflammatory disease ": 7.775901971141212, "Pelvic pain ": 2.351586182780637, "Peripheral coldness ": 4.1912639708944885, "Peripheral paralysis ": 8.092680980914258, "Peripheral vascular disorder ": 3.770380738095266, "Personality change ": 2.1388317055107806, "Petit mal epilepsy ": 2.7736409903945827, "Pharyngeal erythema ": 2.415028433920557, "Pharyngitis ": 3.817038147783936, "Pharyngitis streptococcal ": 5.188792845996884, "Phonophobia ": 8.609841751386828, "Photophobia ": 7.178833634746916, "Pineal gland cyst ": 31.89632822653764, "Pityriasis rosea ": 3.54756628266662, "Polyarthritis ": 2.7289772784054187, "Polycystic ovarian syndrome ": 22.053125387903727, "Polymyositis ": 2.072305104696043, "Post vaccination syndrome ": 3.322719634718234, "Post-traumatic stress disorder ": 2.764295341272708, "Postictal state ": 6.998001069471346, "Postural orthostatic tachycardia syndrome ": 89.93581689493419, "Posture abnormal ": 8.586208258678164, "Pre-eclampsia ": 3.0442574078627533, "Premature labour ": 2.631775490923829, "Premature menopause ": 16.00694302108516, "Premature rupture of membranes ": 2.2741795034101595, "Presyncope ": 5.7534832119186845, "Product administered at inappropriate site ": 3.547148327329185, "Product administered to patient of inappropriate age ": 2.633318660205244, "Product lot number issue ": 42.803307723476735, "Product name confusion ": 7.150586329123432, "Product origin unknown ": 63.06277500021524, "Psychogenic seizure ": 8.852669974974052, "Raynaud's phenomenon ": 3.866568026699421, "Reading disorder ": 3.653497583362144, "Reflux gastritis ": 2.867914524971113, "Relapsing-remitting multiple sclerosis ": 7.419074552804084, "Respiratory distress ": 2.1280458582157817, "Sacroiliitis ": 4.098291570171042, "School refusal ": 37.88538870542823, "Scoliosis ": 3.064880378955511, "Seasonal allergy ": 2.0593722454874515, "Seizure ": 4.150246637273334, "Seizure like phenomena ": 13.101988054353564, "Self esteem decreased ": 3.197060104500168, "Sensory disturbance ": 5.816793233418414, "Sensory level abnormal ": 2.025440118718391, "Sensory loss ": 3.359104150906897, "Serum ferritin decreased ": 3.985084809183125, "Serum sickness ": 3.4222455352845254, "Sinus arrhythmia ": 4.011747036133462, "Sjogren's syndrome ": 2.0507832578007363, "Skin laceration ": 2.081268315813245, "Skin papilloma ": 5.957155275798578, "Skin striae ": 10.109748111838549, "Skull fracture ": 4.728530957616817, "Sleep disorder ": 2.472838215558343, "Small fibre neuropathy ": 8.297698284434189, "Small for dates baby ": 3.3728275618111363, "Smear cervix abnormal ": 96.01306276343556, "Smear cervix normal ": 294.7495062299504, "Social avoidant behaviour ": 4.90207343166977, "Somatic symptom disorder ": 15.360080516056057, "Staring ": 6.79695711062048, "Still's disease ": 2.8314761302845426, "Streptococcus test positive ": 6.955982603534175, "Substance use ": 3.1297115722718534, "Syncope ": 10.00299991856321, "Temperature intolerance ": 2.534298848519278, "Temperature regulation disorder ": 3.3714104182582108, "Tension headache ": 2.118309119424083, "Tetany ": 4.741035066336757, "Thrombocytopenic purpura ": 2.1534052927377694, "Tic ": 6.941868560183478, "Tongue biting ": 3.2083603613432325, "Tonic clonic movements ": 27.801345092527264, "Tonic convulsion ": 3.0766820110088275, "Tonsillectomy ": 4.62571182282145, "Tonsillitis ": 3.8434976311010542, "Type 1 diabetes mellitus ": 3.632634075617855, "Type III immune complex mediated reaction ": 4.682837326379925, "Underweight ": 2.4842726759569738, "Unresponsive to stimuli ": 3.2682859686038674, "Urinary incontinence ": 2.2921957299204183, "Vaccination complication ": 13.765638125900646, "Vaccination error ": 11.796504318858885, "Vaccination site cellulitis ": 10.109298148657416, "Vaccination site granuloma ": 5.39448124161537, "Vaccination site haemorrhage ": 2.211264244502202, "Vaccination site nodule ": 8.801688959630235, "Vaccine positive rechallenge ": 88.77815959694844, "Vascular malformation ": 11.40501691928078, "Viral infection ": 4.218242778195194, "Vision blurred ": 2.0010283589405917, "Vitamin B12 deficiency ": 2.192588415701701, "Vitamin D decreased ": 2.600567244642193, "Walking disability ": 2.061062885187697, "Wheelchair user ": 5.163870363645093} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/496.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/496.json new file mode 100644 index 00000000000..654c3dbba84 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/496.json @@ -0,0 +1 @@ +{"Asthenia ": 3.0230706475365565, "Blood pressure increased ": 2.729743293333726, "Constipation ": 4.832476487321132, "Disease progression ": 4.597574737685297, "Haemoglobin decreased ": 5.329737906351069, "Hypertension ": 2.4760055626867725, "Interstitial lung disease ": 4.413154285043648, "Myelosuppression ": 4.963177993943318, "Platelet count decreased ": 4.198244499545837, "Pneumonia ": 2.210008769813186, "White blood cell count decreased ": 8.64198337776074} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/497.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/497.json new file mode 100644 index 00000000000..e44aa13ee2e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/497.json @@ -0,0 +1 @@ +{"Agranulocytosis ": 4.248517937858285, "Blood lactate dehydrogenase increased ": 5.683274155706481, "Blood pressure decreased ": 2.399455010322553, "Bronchospasm ": 4.758965037954392, "Chronic lymphocytic leukaemia recurrent ": 153.9177200122778, "Cytokine release syndrome ": 7.439178634620165, "Cytopenia ": 9.674967489012186, "Disease progression ": 3.8285437968358393, "Febrile neutropenia ": 3.821791946146434, "Flushing ": 3.347854905861323, "Follicular lymphoma ": 82.14643210998236, "Hepatic cytolysis ": 8.076937563672756, "Hepatitis ": 2.020561315200754, "Hyperhidrosis ": 2.236148330981218, "Hypertransaminasaemia ": 5.860827136769324, "Hypotension ": 4.517922185532386, "Hypoxia ": 2.6807289258052616, "Ill-defined disorder ": 2.460101203810525, "Infection ": 2.8107207937120644, "Infusion related reaction ": 46.704607631476414, "Intentional product use issue ": 6.243268441841447, "Leukopenia ": 6.63119853651579, "Liver function test abnormal ": 2.197509857588608, "Lymphocyte count decreased ": 11.794093682792798, "Lymphopenia ": 10.1813265001177, "Neutropenia ": 15.80752821067424, "Neutropenic sepsis ": 16.682693453617606, "Off label use ": 2.362484445409136, "Oxygen saturation decreased ": 4.756680736940636, "Pancytopenia ": 3.1488774714946244, "Platelet count decreased ": 4.223588009009061, "Progressive multifocal leukoencephalopathy ": 61.29121853312946, "Respiratory distress ": 2.094093299040895, "Respiratory failure ": 2.448010234914632, "Respiratory tract infection ": 10.827224774667783, "Sepsis ": 3.75867993528057, "Septic shock ": 3.751810518334477, "Splenomegaly ": 5.186336641566154, "Thrombocytopenia ": 10.331459565471992, "Transaminases increased ": 5.2146579646320905, "Tumour lysis syndrome ": 111.77361695970691, "White blood cell count decreased ": 3.625977881056468} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/498.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/498.json new file mode 100644 index 00000000000..03ceefd10a9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/498.json @@ -0,0 +1 @@ +{"Acquired gene mutation ": 1332.9235146927251, "Alanine aminotransferase increased ": 2.94912070123708, "Aspartate aminotransferase increased ": 2.2138362594757086, "Dermatitis acneiform ": 51.80496949539893, "Diarrhoea ": 2.5027644868259267, "Disease progression ": 8.704496992032258, "Drug interaction ": 2.170150005911798, "Drug resistance ": 149.64231670061238, "Drug-induced liver injury ": 6.502114492984986, "EGFR gene mutation ": 3703.5645799823487, "Gene mutation ": 76.17624291310764, "Hepatic function abnormal ": 6.852372897748949, "Hepatotoxicity ": 12.271814291520244, "Interstitial lung disease ": 15.91222092680261, "Left ventricular dysfunction ": 13.46179432791123, "Liver function test abnormal ": 5.501414530026557, "Liver injury ": 5.327021095731904, "Lung adenocarcinoma ": 47.32440281927434, "Lung adenocarcinoma stage IV ": 369.3220082985871, "Malignant neoplasm progression ": 51.87421790053863, "Malignant transformation ": 2091.4869565741496, "Metastases to bone ": 35.13422829398389, "Metastases to central nervous system ": 137.6437376626633, "Metastases to liver ": 24.86186010700512, "Metastases to lung ": 36.13115434155291, "Metastases to lymph nodes ": 20.77716717434163, "Metastases to meninges ": 393.0899666966118, "Metastasis ": 23.41666785477021, "Myelosuppression ": 2.814276526251704, "Non-small cell lung cancer ": 28.23458809957795, "Pancreatitis acute ": 3.5635039625955947, "Paronychia ": 87.68899063871469, "Pericardial effusion ": 3.7159938383499753, "Pleural effusion ": 7.3092818920871, "Pneumonitis ": 4.128659506926195, "Pulmonary mass ": 6.943093835059006, "Rash ": 3.1164285753662577, "Rash pruritic ": 2.988448749588748, "Rash pustular ": 14.735475412541208, "Respiratory failure ": 2.753170958813442, "Skin toxicity ": 48.854939917171336, "Small cell lung cancer ": 241.04846799687147, "Transaminases increased ": 4.3834987735786095} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/499.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/499.json new file mode 100644 index 00000000000..3db2c04c0ee --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/499.json @@ -0,0 +1 @@ +{"Exposure during pregnancy ": 10.110248300423528, "Hypotonia ": 38.236220074488855} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/5.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/5.json new file mode 100644 index 00000000000..34259b856ef --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/5.json @@ -0,0 +1 @@ +{"Disease progression ": 102.944575958747} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/50.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/50.json new file mode 100644 index 00000000000..56b854e4396 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/50.json @@ -0,0 +1 @@ +{"Abdominal pain ": 6.253153425659666, "Anaemia ": 7.573133338189613, "Chronic sinusitis ": 187.57056845762975, "Colitis ": 52.142493528516816, "Colitis ulcerative ": 54.707103603432806, "Constipation ": 12.740764314155877, "Drug ineffective ": 2.548889891292984, "Erythema ": 6.745671411025831, "Female genital tract fistula ": 297.0486247413064, "Frequent bowel movements ": 106.10161277887882, "Haematochezia ": 34.126519537307274, "Macular degeneration ": 103.1497414299534, "Malaise ": 2.201146362300357, "Off label use ": 3.880435553525409, "Oral candidiasis ": 108.67658809148702, "Pain ": 2.930915342815897, "Paraesthesia oral ": 48.55558979401639, "Proctitis ": 260.373752025888, "Radiculopathy ": 226.210064349624, "Rectal haemorrhage ": 39.60665694701842, "Vaginal discharge ": 164.720966623618, "Vaginal flatulence ": 351.0289539109318, "Weight decreased ": 9.531297239540326} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/500.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/500.json new file mode 100644 index 00000000000..0ec6dbff7df --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/500.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 6.497984733688627, "Abnormal weight gain ": 42.45953955944619, "Abortion induced ": 15.898322827889846, "Abortion spontaneous ": 4.043792838386082, "Acne ": 3.6600306136655134, "Blood HIV RNA increased ": 247.8087451022996, "Blood cholesterol increased ": 2.805383525788392, "Blood creatinine increased ": 5.129126880869724, "Blood triglycerides increased ": 7.239790169897224, "CD4 lymphocytes decreased ": 119.993372288535, "Cushing's syndrome ": 58.80559164885881, "Drug ineffective ": 2.211442552066996, "Drug interaction ": 8.065500855669791, "Drug resistance ": 19.78828288861536, "Electrocardiogram QT prolonged ": 2.024462664843837, "Erectile dysfunction ": 3.774034089626056, "Fanconi syndrome acquired ": 17.858175899779543, "Flatulence ": 3.347664316183144, "Gastrointestinal tube insertion ": 52.6857427621192, "Gastrostomy ": 58.36946654505461, "Genotype drug resistance test positive ": 109.00034409569749, "Glomerular filtration rate decreased ": 11.564132450969906, "Hypercholesterolaemia ": 11.364104759277613, "Hypophosphataemia ": 15.986854278908874, "Immune reconstitution inflammatory syndrome ": 25.972807278919174, "Lactic acidosis ": 2.432816034194554, "Maternal exposure during pregnancy ": 5.323618502408802, "Mental disorder ": 2.5728594074446365, "Nightmare ": 4.244136125566038, "Osteonecrosis ": 3.2009706595492253, "Osteoporosis ": 3.61735310944852, "Renal impairment ": 3.497231902671679, "Rhabdomyolysis ": 2.3981420925930146, "Treatment failure ": 4.39197973060792, "Treatment noncompliance ": 14.371531536341797, "Tuberculosis ": 7.518712043146201, "Viral load increased ": 124.54115527873388, "Virologic failure ": 48.04037800029135, "Weight increased ": 14.713144842688632, "Wrong technique in product usage process ": 2.0275586377277617} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/501.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/501.json new file mode 100644 index 00000000000..a800f32b74b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/501.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 3.046611549873918, "Balance disorder ": 3.359439326763692, "Blood pressure decreased ": 2.119553690057187, "Central nervous system lesion ": 101.42805789536058, "Gait disturbance ": 3.163418741868322, "Gamma-glutamyltransferase increased ": 5.714944132661755, "Hepatocellular injury ": 17.187168117464328, "Lymphocyte count decreased ": 42.09043696906324, "Memory impairment ": 2.5974757118218323, "Mobility decreased ": 2.103802492704021, "Movement disorder ": 7.327885998189389, "Multiple sclerosis ": 15.36785179420972, "Multiple sclerosis relapse ": 50.62157833187744, "Muscle spasms ": 2.3840007662375875, "Muscular weakness ": 2.4229811879196266, "Musculoskeletal stiffness ": 2.636150437711364, "Prescribed underdose ": 10.849328929140706, "Stress ": 9.27220948299212, "Urinary tract infection ": 3.4796650318437736, "Vision blurred ": 2.3574777980921424, "Visual impairment ": 2.2612639621503563, "Weight increased ": 2.8041880415230245, "White blood cell count decreased ": 3.035252966684209} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/502.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/502.json new file mode 100644 index 00000000000..81116a5bcd6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/502.json @@ -0,0 +1 @@ +{"Off label use ": 5.159578181043231, "Product use issue ": 19.95552235996222} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/503.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/503.json new file mode 100644 index 00000000000..8be79d9f524 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/503.json @@ -0,0 +1 @@ +{"Decreased appetite ": 4.022146304723201, "Diarrhoea ": 7.461938157045687, "Eosinophil count increased ": 116.62312369149006, "Interstitial lung disease ": 9.816971239455752, "Malignant neoplasm progression ": 9.972907481194987, "Rash ": 4.417139581706117, "Vomiting ": 2.663433536452429} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/504.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/504.json new file mode 100644 index 00000000000..2fcba656d24 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/504.json @@ -0,0 +1 @@ +{"Hepatocellular carcinoma ": 577.3223763570121} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/505.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/505.json new file mode 100644 index 00000000000..0b22c7e9f9b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/505.json @@ -0,0 +1 @@ +{"Accidental exposure to product ": 9.795380822874098, "Accidental overdose ": 6.221685489167692, "Acute kidney injury ": 2.577669694090112, "Altered state of consciousness ": 8.079651360125947, "Angina pectoris ": 2.21251521654856, "Anuria ": 12.081899525524816, "Blood alkaline phosphatase increased ": 2.1133991457305017, "Blood glucose decreased ": 6.087563785479241, "Blood glucose increased ": 3.96832630937974, "Cardiac arrest ": 2.453516639566473, "Circulatory collapse ": 2.166189922860537, "Coma ": 3.787670881894487, "Completed suicide ": 10.453529395671554, "Confusional state ": 2.835950971867355, "Conjunctivitis ": 4.372939724984836, "Counterfeit product administered ": 134.63686688493428, "Depressed level of consciousness ": 2.483960358131197, "Diabetes mellitus ": 2.577830737863397, "Diabetes mellitus inadequate control ": 8.447044086679902, "Diabetic metabolic decompensation ": 35.260944383327974, "Drug interaction ": 7.104544659220222, "Drug-induced liver injury ": 6.102421042908908, "Dyspepsia ": 2.2505005264179623, "Glycosylated haemoglobin increased ": 10.995062700252134, "Hemiparesis ": 4.794773706938801, "Hemiplegia ": 7.03976088340772, "Hepatitis ": 2.4547530042717267, "Hepatitis cholestatic ": 5.460949687430225, "Hyperglycaemia ": 4.706674707957352, "Hyperosmolar state ": 292.1432991117906, "Hypoglycaemia ": 51.17085652926136, "Hypoglycaemic coma ": 39.63162497496122, "Hypoglycaemic encephalopathy ": 109.90323462233904, "Hypomagnesaemia ": 11.499718958336542, "Intentional overdose ": 4.961168312689323, "Ischaemic cardiomyopathy ": 19.06529631221713, "Ketoacidosis ": 6.751282271018541, "Lactic acidosis ": 8.31553636135406, "Liver injury ": 2.981297510437962, "Loss of consciousness ": 2.5160774022959425, "Magnetic resonance imaging head abnormal ": 61.25440741479058, "Medication error ": 5.299132169168445, "Metabolic acidosis ": 5.124426232136686, "Oedema peripheral ": 2.566651853169521, "Overdose ": 5.82406378973073, "Potentiating drug interaction ": 15.534782092063216, "Product administration error ": 2.712001718556157, "Prothrombin time prolonged ": 8.817379841070919, "Respiratory acidosis ": 22.66230604191093, "Respiratory arrest ": 2.537681922005944, "Speech disorder ": 2.7727315351549358, "Suicide attempt ": 3.2095868498185336, "Toxic epidermal necrolysis ": 4.464358534980282, "Toxicity to various agents ": 7.289764147767682, "Treatment noncompliance ": 3.5067249534129985, "Unresponsive to stimuli ": 9.77031366872226, "Vertigo ": 2.5014505983458872} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/506.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/506.json new file mode 100644 index 00000000000..d7b967525ce --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/506.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 3.155830942503086, "Amylase increased ": 6.833184366588426, "Anaemia ": 2.0840723440929416, "Ascites ": 3.7386500859838, "Aspartate aminotransferase increased ": 3.002318861259404, "Blast crisis in myelogenous leukaemia ": 151.94204221717925, "Blood alkaline phosphatase increased ": 2.255657290512484, "Blood bilirubin increased ": 4.727285422385485, "Blood creatine phosphokinase increased ": 2.186224402457388, "Blood creatinine increased ": 2.113209105200056, "Blood lactate dehydrogenase increased ": 6.630800153905613, "Blood urea increased ": 2.895534618079424, "Cardiac failure ": 3.492946868742859, "Cholestasis ": 2.728410474128639, "Chronic myeloid leukaemia ": 71.92088625322938, "Cytogenetic analysis abnormal ": 121.67699341122147, "Cytopenia ": 5.404369366278683, "Disease progression ": 2.0473689667708865, "Disseminated intravascular coagulation ": 3.967847195584105, "Drug interaction ": 2.556150195732858, "Drug intolerance ": 3.5773576897477954, "Drug level increased ": 2.895876863807616, "Drug resistance ": 11.69634249410196, "Dry skin ": 2.430498185370144, "Dyspnoea exertional ": 2.1223782339139228, "Eyelid oedema ": 7.052587376183572, "Face oedema ": 4.190474902876286, "Fluid retention ": 4.104582543104602, "Gamma-glutamyltransferase increased ": 2.202234744166533, "Gastrointestinal stromal tumour ": 339.22883004376786, "Gene mutation identification test positive ": 112.40264336280148, "Generalised oedema ": 8.991406170302016, "Haematocrit decreased ": 3.902234984905897, "Haematotoxicity ": 7.928366869414983, "Haemoglobin decreased ": 2.85573832516597, "Hepatic cytolysis ": 2.734300830273523, "Hepatomegaly ": 6.477623546234107, "Interstitial lung disease ": 3.256985486366577, "Liver disorder ": 2.751413058219708, "Lymphocyte count increased ": 30.45990786871446, "Malignant neoplasm progression ": 16.61708138935664, "Metastases to bone ": 3.703569971895906, "Metastases to liver ": 21.08590054413992, "Metastases to peritoneum ": 34.11910597613456, "Metastasis ": 10.76041380931471, "Neoplasm progression ": 4.218123562435118, "Neoplasm recurrence ": 89.01957280268876, "Neutrophil count decreased ": 2.174003328057586, "Oedema ": 7.841440942489659, "Oedema peripheral ": 3.602497233283783, "Pancytopenia ": 5.522855685862163, "Pericardial effusion ": 2.972249723445658, "Periorbital oedema ": 10.545992373431394, "Platelet count decreased ": 4.2490119531061685, "Platelet count increased ": 4.857422139270834, "Pleural effusion ": 9.489629644111986, "Pulmonary fibrosis ": 2.498061624517764, "Pulmonary hypertension ": 3.956278344060807, "Red blood cell count decreased ": 2.623605299030118, "Second primary malignancy ": 22.180719621427308, "Skin exfoliation ": 3.3793741361913217, "Splenomegaly ": 4.059251768089615, "Squamous cell carcinoma ": 7.430656658134777, "Subdural haematoma ": 4.243015128614345, "Therapeutic response decreased ": 5.865927545672381, "Thrombocytopenia ": 2.0423116207111267, "White blood cell count decreased ": 3.2449237429848106, "White blood cell count increased ": 7.808149539327949} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/507.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/507.json new file mode 100644 index 00000000000..c7647e8c367 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/507.json @@ -0,0 +1 @@ +{"Cytokine release syndrome ": 625.5810417020712} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/508.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/508.json new file mode 100644 index 00000000000..4e18c3301b7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/508.json @@ -0,0 +1 @@ +{"Accidental overdose ": 5.725508664208805, "Acute kidney injury ": 2.315185461083165, "Altered state of consciousness ": 3.375257157275059, "Anaphylactic shock ": 2.314713020934067, "Blood glucose abnormal ": 6.807152851030573, "Blood glucose decreased ": 48.71665973824195, "Blood glucose increased ": 6.739463185007669, "Blood pressure decreased ": 3.3064462273079416, "Bradycardia ": 11.913955633636368, "Cardiac arrest ": 22.185338824506704, "Cardiogenic shock ": 33.14749217031573, "Circulatory collapse ": 5.373584282813225, "Coma ": 3.0211698752762173, "Coma scale abnormal ": 108.83144302429626, "Compartment syndrome ": 194.11095942823283, "Completed suicide ": 4.21177125709921, "Diabetic ketoacidosis ": 4.34660284657334, "Drug ineffective ": 5.02840652398542, "Drug screen positive ": 55.20627207166592, "Expired product administered ": 29.898897788173056, "General physical health deterioration ": 2.9611934369234327, "Haemodynamic instability ": 25.63312861873641, "Hyperglycaemia ": 3.664733570106926, "Hyperkalaemia ": 6.979467708295187, "Hypoglycaemia ": 7.743640885452296, "Hypoglycaemic coma ": 11.010667654901065, "Hypoglycaemic seizure ": 34.40708570720253, "Hypoglycaemic unconsciousness ": 29.10304710028644, "Hypotension ": 4.66301321708725, "Hypoxic-ischaemic encephalopathy ": 87.4524883122731, "Ileus ": 40.15298729404237, "Incorrect dose administered ": 6.476510556395466, "Intentional overdose ": 7.143546894706867, "Lactic acidosis ": 18.29339663212248, "Loss of consciousness ": 4.92958606716744, "Mental status changes ": 16.45119628948413, "Metabolic acidosis ": 5.638466002694288, "Overdose ": 4.220962392169906, "Product dose omission issue ": 2.060998830785458, "Pulmonary oedema ": 3.5913178479123147, "Pulse absent ": 88.60645199749415, "Pulseless electrical activity ": 64.35217573762536, "Pupil fixed ": 82.10159750584485, "Respiratory depression ": 17.646401564870867, "Rhabdomyolysis ": 7.381719612016032, "Seizure ": 3.52075660027208, "Shock ": 16.698931492150127, "Therapy non-responder ": 4.22074370129061, "Toxicity to various agents ": 4.284395064895399, "Underdose ": 10.913071924340004, "Unresponsive to stimuli ": 5.312935100752528, "Vasoplegia syndrome ": 430.11637551698135, "Ventricular tachycardia ": 9.349221107426205, "Wrong technique in product usage process ": 3.338051756732825} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/509.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/509.json new file mode 100644 index 00000000000..9f5aac164f0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/509.json @@ -0,0 +1 @@ +{"Drug ineffective ": 5.558796623389982, "Product use in unapproved indication ": 12.8056308144212} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/51.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/51.json new file mode 100644 index 00000000000..241de36ee19 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/51.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 2.617058852760312, "Acute generalised exanthematous pustulosis ": 2.690328480427259, "Acute kidney injury ": 3.555821019126201, "Acute pulmonary oedema ": 2.6168619496727743, "Acute respiratory failure ": 2.7962291805598927, "Alanine aminotransferase increased ": 2.091530432423037, "Anaemia ": 6.453276168811002, "Aspartate aminotransferase increased ": 2.2557852986376656, "Bicytopenia ": 8.5834952554688, "Blood creatinine increased ": 2.987016799152558, "Blood magnesium decreased ": 3.086813710840838, "Bone marrow failure ": 20.46912666549953, "C-reactive protein increased ": 2.333829419537141, "Cellulitis ": 2.0837567409464275, "Cerebral infarction ": 2.3467513619486966, "Cholestasis ": 2.7498367473777408, "Colitis ": 5.33372639244486, "Colitis ischaemic ": 3.015439272301613, "Congenital aplasia ": 34.66324134269079, "Conjunctivitis ": 4.653762108630027, "Creatinine renal clearance decreased ": 10.038157603883564, "Cytopenia ": 2.4674156962593914, "Death ": 2.133419272886312, "Decreased appetite ": 2.4469540187018746, "Dehydration ": 2.515387220258124, "Dermatitis ": 3.381060798117484, "Dermatitis bullous ": 3.992593480382662, "Dermatitis exfoliative generalised ": 2.545215994788846, "Dermo-hypodermitis ": 41.13463772213367, "Disease progression ": 2.222518193787234, "Disseminated intravascular coagulation ": 4.687109409484428, "Drug eruption ": 2.247294419904118, "Enteritis ": 6.178735748091023, "Enterocolitis ": 6.342254726887617, "Erysipelas ": 9.190805937962253, "Eyelid oedema ": 2.545970090401545, "Febrile bone marrow aplasia ": 45.737569991035, "Febrile neutropenia ": 11.926965603202683, "Gastrointestinal necrosis ": 7.540149650996057, "Gastrointestinal perforation ": 4.130067607171318, "Gastrointestinal toxicity ": 4.251609047365809, "General physical health deterioration ": 3.3219538157415496, "Generalised oedema ": 3.466945943486511, "Granulocytopenia ": 2.359095986139691, "Haematocrit decreased ": 2.4102747656145813, "Haematotoxicity ": 18.18047000409302, "Haemoglobin decreased ": 2.6613181790944767, "Haemolytic anaemia ": 2.222335508831179, "Haemoptysis ": 4.193107464974718, "Hepatic cytolysis ": 6.05624656232113, "Hepatocellular injury ": 4.680294300918038, "Hiccups ": 5.019894154420486, "Hospice care ": 17.62796954419729, "Hypertransaminasaemia ": 6.236898858634018, "Hypoalbuminaemia ": 3.3909226247658046, "Hypocalcaemia ": 2.173852545930351, "Hypomagnesaemia ": 2.4718487309531003, "Hypophagia ": 2.0094844354584547, "Ileus ": 2.156734372783618, "Immune-mediated enterocolitis ": 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"Performance status decreased ": 3.5968138033072456, "Pericardial effusion ": 2.409438826500479, "Periorbital oedema ": 2.177206815011948, "Peripheral ischaemia ": 3.4355198825332045, "Peripheral sensory neuropathy ": 2.454926443280172, "Peritonitis ": 3.129826647901603, "Platelet count decreased ": 5.816457706133234, "Pleural effusion ": 5.273227639183809, "Pneumonia bacterial ": 2.7835395416865327, "Pneumonitis ": 16.13262891593914, "Pneumothorax ": 3.910957483134511, "Pulmonary fibrosis ": 2.1651331781184164, "Pulmonary toxicity ": 4.386769903852649, "Purpura ": 2.9734339382927057, "Radiation pneumonitis ": 26.29113537833904, "Rash maculo-papular ": 3.498597603812271, "Recall phenomenon ": 104.6420389196962, "Renal disorder ": 2.302294347555595, "Renal failure ": 3.8701610265979496, "Renal impairment ": 3.1511603449487717, "Renal tubular necrosis ": 4.194583772143596, "Respiratory failure ": 2.773193481391213, "Sepsis ": 3.4931073339188154, "Septic shock ": 6.783709797899157, "Skin 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5.918613933203575, "Full blood count abnormal ": 66.17129266597702, "Gastrooesophageal reflux disease ": 18.322820597305565, "Glaucoma ": 12.489912142733584, "Haemoglobin decreased ": 5.51214585661806, "Hilar lymphadenopathy ": 109.3371858324765, "Hip fracture ": 4.21348263076589, "Hospitalisation ": 4.657433800374021, "Hypercholesterolaemia ": 80.32487096122237, "Hypersensitivity ": 2.0262044747623738, "Hyperthyroidism ": 3.854256490556567, "Hypogammaglobulinaemia ": 34.792259578287414, "Infection ": 6.229394483446552, "Laryngospasm ": 19.779587415293364, "Loss of personal independence in daily activities ": 28.87663885538977, "Lower respiratory tract infection ": 2.5610268125243865, "Nervousness ": 3.25780036988099, "Neutrophil count decreased ": 8.062605181958121, "Obesity ": 66.4218957243778, "Obstructive airways disorder ": 44.02344786435396, "Oxygen saturation decreased ": 4.032460186567593, "Productive cough ": 35.22558742791208, "Pulmonary mass ": 16.43957354278706, "Respiratory disorder ": 4.817130224566473, "Respiratory symptom ": 25.36879956410619, "Rhinitis allergic ": 175.31064955010729, "Sinus congestion ": 68.02362408683393, "Sleep disorder ": 2.3973991503472942, "Sleep disorder due to a general medical condition ": 134.64073509343035, "Sputum discoloured ": 81.47849535863254, "Therapeutic product effect incomplete ": 33.59464907354145, "Total lung capacity increased ": 632.3955860102072, "Upper-airway cough syndrome ": 75.31106485651519, "Wheezing ": 41.11811373712996} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/511.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/511.json new file mode 100644 index 00000000000..e00551ee228 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/511.json @@ -0,0 +1 @@ +{"Ectopic pregnancy ": 32649.084267910934} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/512.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/512.json new file mode 100644 index 00000000000..7985e57cd53 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/512.json @@ -0,0 +1 @@ +{"Arthritis ": 6.00074716211868, "Colitis ulcerative ": 8.373608110345094, "Drug ineffective ": 3.902474042084593, "Infection ": 5.081654607398911, "Lymphoproliferative disorder ": 171.54023905889187, "Pneumonia ": 2.6547594146589923, "Psoriasis ": 17.33678070325074, "Psoriatic arthropathy ": 8.370060998611207, "Rheumatoid arthritis ": 6.935613258051929, "Therapeutic product effect decreased ": 6.12036585884248} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/513.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/513.json new file mode 100644 index 00000000000..274eb3b1e11 --- 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6.385225455519896, "Tension ": 46.24916265749008, "Uterine hyperstimulation ": 661.570138984048} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/514.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/514.json new file mode 100644 index 00000000000..122a03de4ed --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/514.json @@ -0,0 +1 @@ +{"Condition aggravated ": 5.928385868020947, "Diarrhoea ": 2.5731732212931555, "Myoclonus ": 73.56009032098757, "Somnolence ": 5.328507709187519} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/515.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/515.json new file mode 100644 index 00000000000..942d447c67a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/515.json @@ -0,0 +1 @@ +{"Death ": 3.9563500719015057} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/516.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/516.json new file mode 100644 index 00000000000..3a2672d252b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/516.json @@ -0,0 +1 @@ +{"Anaphylactic reaction ": 5.356348745497177, "Dizziness ": 2.3832392380405856, "Drug hypersensitivity ": 6.644100079975162, "Epistaxis ": 5.038003607299718, "Erythema ": 3.273276644604053, "Flushing ": 11.412226414164977, "Haematoma ": 11.971011002331942, "Hypotension ": 3.227803350307052, "Oesophageal carcinoma ": 63.390300370528976, "Product formulation issue ": 480.6615881764384, "Reaction to excipient ": 197.4792364666786, "Sneezing ": 37.0227655022944, "Therapeutic response unexpected ": 25.80951651850826, "Urticaria ": 3.42870808107878} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/517.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/517.json new file mode 100644 index 00000000000..6bd2fb3d6c0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/517.json @@ -0,0 +1 @@ +{"Agitation ": 11.156048848624554, "Completed suicide ": 17.75102651727286, "Drug ineffective ": 3.625738975710165, "Hyperhidrosis ": 4.218709718398258, "Hypotension ": 4.81905046637191, "Intentional overdose ": 10.284906114126846, "Intentional product misuse ": 11.072050637112987, "Off label use ": 3.288013869535126, "Toxicity to various agents ": 5.460121416690418} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/518.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/518.json new file mode 100644 index 00000000000..b2c912aafb4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/518.json @@ -0,0 +1 @@ +{"Drug ineffective ": 3.820263992439816, "Product use in unapproved indication ": 4.319829252134142, "Psoriasis ": 19.823778766041663} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/519.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/519.json new file mode 100644 index 00000000000..4f57d9da287 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/519.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 37.949377586317965, "Hypophosphataemia ": 705.89987823997, "Rhabdomyolysis ": 216.35069088426985} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/52.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/52.json new file mode 100644 index 00000000000..1f6ff350c07 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/52.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.0949800380869155, "Abortion induced ": 7.844961259580289, "Adjustment disorder ": 818.985859999993, "Affect lability ": 133.22036544089312, "Amnesia ": 7.837733242049719, "Angina pectoris ": 20.746562321922468, "Anxiety ": 6.056960094960443, "Aphasia ": 43.04666273680289, "Arterial occlusive disease ": 138.6771059963094, "Arthritis ": 14.833735459789397, "Atrioventricular block ": 4.502040066685692, "Blood potassium increased ": 4.446608314713722, "Blood pressure inadequately controlled ": 76.07040974156008, "Blood pressure increased ": 6.847405359181285, "Cardiac failure ": 3.0825206504263787, "Cardiac failure chronic ": 12.410163552259036, "Cardiac septal defect ": 66.91960566720492, "Carotid artery thrombosis ": 1761.9388493684608, "Cataract ": 21.68466296111506, "Cerebrovascular accident ": 10.399097763414634, "Chest discomfort ": 5.893821820609416, "Cognitive disorder ": 11.179018053497956, "Concomitant disease progression ": 66.99145028005182, "Confusional state ": 8.285165651601863, "Congenital cardiovascular anomaly ": 34.63964857021566, "Conjoined twins ": 921.3235149663088, "Contusion ": 6.2339418931359285, "Coordination abnormal ": 108.41998079298318, "Cough ": 3.16219596255814, "Cystitis ": 45.17170950493468, "Depressed mood ": 8.57322193773132, "Diabetes mellitus inadequate control ": 16.3668090258124, "Dysarthria ": 33.258109450506424, "Dysphagia ": 17.41312533918719, "Eating disorder ": 92.83224784284614, "Electrolyte imbalance ": 4.600457955448892, "Exercise tolerance decreased ": 41.13310261376232, "Fall ": 7.176319497335696, "Foetal exposure during pregnancy ": 2.6157851035844315, "Gangrene ": 201.6938769709754, "Gastrointestinal disorder ": 11.276925693241903, "Haemoglobin abnormal ": 19.86643666036015, "Heart disease congenital ": 9.782031862423205, "Hemiparesis ": 73.63442192676031, "Hemiplegia ": 122.12495515961616, 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"Ventricular tachycardia ": 3.897876771030065} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/520.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/520.json new file mode 100644 index 00000000000..2cb93c5cb2d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/520.json @@ -0,0 +1 @@ +{"Alopecia ": 4.504042453475993, "Anaemia ": 3.588244028722119, "Aphthous ulcer ": 3.443729630799968, "Aspartate aminotransferase increased ": 2.167362873166672, "Asthenia ": 2.35350036366075, "Ataxia ": 2.2111469409884283, "Cardiac failure ": 3.862892276276353, "Conjunctivitis ": 2.4274476494459893, "Cystitis haemorrhagic ": 7.96119926418608, "Decreased appetite ": 2.1753735611164804, "Disseminated intravascular coagulation ": 5.112163176540674, "Drug-induced liver injury ": 3.1132428467023847, "Enterocolitis ": 8.024529103344896, "Febrile neutropenia ": 62.68894754290422, "Granulocytopenia ": 4.471960678263996, "Hepatic cirrhosis ": 2.8865913712369187, "Hepatic failure ": 3.975270799516212, "Hepatic function abnormal ": 3.643069809509709, "Hyperbilirubinaemia ": 2.5689827564013554, "Hyperpyrexia ": 2.8565623223516066, "Hypertransaminasaemia ": 10.720124075044732, "Hypoacusis ": 2.378541856073025, "Interstitial lung disease ": 20.86194701529745, "Leukopenia ": 21.3628244842576, "Lymphopenia ": 4.667670654744531, "Malignant neoplasm progression ": 12.269189941285596, "Metastases to central nervous system ": 6.281793230317255, "Mouth ulceration ": 3.0329397701465703, "Mucosal inflammation ": 16.62397688200028, "Myelosuppression ": 30.660202447203687, "Neuropathy peripheral ": 15.915323204043828, "Neurotoxicity ": 6.94467427494983, "Neutropenia ": 31.147048360758237, "Neutropenic sepsis ": 14.272453684068877, "Neutrophil count decreased ": 22.60674901234608, "Palmar-plantar erythrodysaesthesia syndrome ": 2.6372436357367146, "Pancytopenia ": 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+++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/521.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 2.697762741304837, "Alpha 1 foetoprotein increased ": 16.875268978623797, "Ammonia increased ": 4.73377396540167, "Anaemia ": 3.0814194850066685, "Anger ": 2.0121463620690245, "Ascites ": 15.005517187332382, "Atrioventricular block second degree ": 4.984759500746836, "Autoimmune hepatitis ": 3.150997217739466, "Blood bilirubin increased ": 4.98981893630443, "Blood creatinine increased ": 2.042799798905388, "Bradycardia ": 2.1070025351553063, "Cholangiocarcinoma ": 17.663420147562075, "Cryoglobulinaemia ": 30.674879948406403, "Drug ineffective ": 10.46466578496998, "Drug interaction ": 2.525806984118276, "Drug resistance ": 4.306003531993655, "Encephalopathy ": 4.8973122787396175, "Endotracheal intubation ": 3.7339567196810086, "Fanconi syndrome acquired ": 3.110091470457843, "Gastritis erosive ": 4.275375886103681, "Genotype drug resistance test positive ": 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4.826400603707151, "Jaundice ": 2.213216338336152, "Liver transplant ": 40.72665666149275, "Lymphoma ": 2.370026319083788, "Metastases to lymph nodes ": 3.209468068523524, "Oesophageal varices haemorrhage ": 39.19669618351153, "Paranoia ": 2.074809780275474, "Plantar fasciitis ": 14.933772300369856, "Portal vein thrombosis ": 9.431582628508904, "Product use complaint ": 4.306244241493999, "Pulmonary arterial hypertension ": 2.038853115278949, "Renal impairment ": 2.469915926328785, "Respiration abnormal ": 3.522637375767661, "Sciatica ": 2.650120604321654, "Septic shock ": 2.443701889236736, "Spinal stenosis ": 5.399517603808179, "Subarachnoid haemorrhage ": 4.102340497844847, "Sudden death ": 4.510365483104159, "Synovial cyst ": 10.089949488553408, "Temperature regulation disorder ": 3.95601656254784, "Therapeutic response unexpected ": 2.027770948388397, "Therapy cessation ": 5.07525202273341, "Therapy non-responder ": 3.3262392671171157, "Thyroid disorder ": 2.6469330240135944, "Treatment failure ": 35.904955202169035, "Treatment noncompliance ": 4.330842342696448, "Unevaluable event ": 2.495931668685869, "Upper gastrointestinal haemorrhage ": 2.9747165137114364, "Varices oesophageal ": 12.72467366239956, "Viral load increased ": 5.1893987753290105, "Viral mutation identified ": 94.03920278309782, "Virologic failure ": 14.99916011346792} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/522.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/522.json new file mode 100644 index 00000000000..9e26dfeeb6e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/522.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/523.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/523.json new file mode 100644 index 00000000000..30d7e5124e2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/523.json @@ -0,0 +1 @@ +{"Anti factor VIII antibody positive ": 2526.0794837119424, "Factor VIII inhibition ": 2562.360690650658, "Haemarthrosis ": 316.6600559403955} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/524.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/524.json new file mode 100644 index 00000000000..0f368ac3655 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/524.json @@ -0,0 +1 @@ +{"Bradycardia ": 16.132973088012957, "Bronchiolitis ": 88.99038388210653, "Drug titration error ": 2301.0846467385527, "Hypoglycaemia ": 23.191139644224226, "Hypoglycaemic seizure ": 309.97633300646106, "Hypotension ": 2.223812821691633, "Irritability ": 11.936885285375954, "Off label use ": 13.713121645871585, "Product administered to patient of inappropriate age ": 229.77071380582444, "Product use issue ": 19.676594100050394, "Sleep disorder ": 21.843204118528053, "Somnolence ": 2.54127000041944} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/525.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/525.json new file mode 100644 index 00000000000..aa9816f8bc0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/525.json @@ -0,0 +1 @@ +{"Activated partial thromboplastin time prolonged ": 72.05148900873449, "Acute myocardial infarction ": 3.300221122539162, "Blood urine present ": 12.771701943754934, "Cerebral haemorrhage ": 3.915056627534883, "Cerebral infarction ": 4.473312702598258, "Contusion ": 5.318568596240191, "Drug level decreased ": 11.93836889004657, "Drug level increased ": 4.259139563805238, "Drug specific antibody present ": 158.56430117260803, "Epistaxis ": 4.401989015957592, "Fall ": 6.730830472188859, "Gastric haemorrhage ": 13.331516630039411, "Gastrointestinal haemorrhage ": 6.294670412179276, "Gingival bleeding ": 13.547923342503749, "Haemarthrosis ": 398.94422635045646, "Haematoma ": 10.673501489683895, "Haematoma muscle ": 32.78587640673578, "Haematuria ": 5.609204308743358, "Haemorrhage ": 77.88142669776944, "Haemorrhage intracranial ": 6.886895254851355, "Head injury ": 32.61547141284012, "Injection site reaction ": 2.481843720567228, "Injury ": 8.666863564110663, "Intentional product use issue ": 3.748389255691916, "Joint injury ": 13.858352433988214, "Joint swelling ": 2.0475177380630503, "Ligament sprain ": 20.438175479098213, "Limb injury ": 8.90856941147081, "Mouth haemorrhage ": 45.31209499041631, "Muscle haemorrhage ": 368.8851761018944, "Nephritis ": 22.588099575935384, "Nephrolithiasis ": 4.4243755029452805, "No adverse event ": 4.966154478585073, "Post procedural haemorrhage ": 26.97633434903145, "Procedural haemorrhage ": 33.57126784887463, "Renal haemorrhage ": 44.88643496986472, "Road traffic accident ": 3.418749076493913, "Skin laceration ": 15.78821221592371, "Spontaneous haemorrhage ": 180.42468064031465, "Subdural haematoma ": 5.7370897854496885, "Therapeutic response decreased ": 3.0126749314159555, "Traumatic haemorrhage ": 261.1155952554108, "Underdose ": 4.63283956594904} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/526.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/526.json new file mode 100644 index 00000000000..d37746dbc6b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/526.json @@ -0,0 +1 @@ +{"Acquired aminoaciduria ": 2329.632271930392, "Alanine aminotransferase increased ": 6.913328566193478, "Aminoaciduria ": 731.2622665216284, "Ascites ": 2.3581492124856798, "Aspartate aminotransferase increased ": 2.7141186718930794, "Back pain ": 4.143619523804344, "Beta 2 microglobulin increased ": 289.51718883776385, "Beta 2 microglobulin urine increased ": 323.52143498466376, "Blood alkaline phosphatase increased ": 28.16834807378762, "Blood bilirubin increased ": 3.3453950080861063, "Blood creatine phosphokinase MB increased ": 37.52840267058623, "Blood creatine phosphokinase increased ": 2.592709736848435, "Blood creatinine increased ": 8.54923707554949, "Blood phosphorus decreased ": 391.6936320071961, "Blood potassium decreased ": 4.202519375968437, "Blood uric acid decreased ": 225.6894386343257, "Bone metabolism disorder ": 190.04427165810185, "Bone pain ": 13.581229409506877, "Creatinine renal clearance decreased ": 21.44767353389637, "Disease recurrence ": 2.2589199340022503, "Drug ineffective ": 2.209775248500202, "Drug resistance ": 48.16925443337597, "Drug tolerance ": 15.61960145484399, "Fanconi syndrome ": 307.7260100795215, "Fanconi syndrome acquired ": 486.0392539776995, "Femoral neck fracture ": 48.62599775848373, "Femur fracture ": 5.182428961977306, "Foot fracture ": 5.8403118744172975, "Fracture ": 10.55615778216707, "Gait disturbance ": 3.527330392331271, "Genotype drug resistance test positive ": 38.522496795404365, "Glomerular filtration rate decreased ": 9.909123720359222, "Glucose urine present ": 100.6072620648826, "Glycosuria ": 47.59055984878525, "Hepatic cancer ": 18.086266146471115, "Hepatic cirrhosis ": 8.428477113072669, "Hepatic failure ": 3.7644806714094976, "Hepatic steatosis ": 4.225463456311646, "Hepatitis ": 3.6994466954406735, "Hepatitis B ": 40.75201156813115, "Hepatitis B DNA assay positive ": 191.44061970449027, "Hepatitis B DNA increased ": 338.42826030452915, "Hepatitis B reactivation ": 44.65817401307872, "Hepatocellular carcinoma ": 12.485046651037486, "Hyperphosphatasaemia ": 925.0294550685296, "Hypophosphataemia ": 389.2838046527665, "Hypophosphataemic osteomalacia ": 1033.3298314677031, "Hypouricaemia ": 1112.684669710175, "Jaundice ": 3.5537000308467173, "Liver disorder ": 2.052152721024981, "Metabolic acidosis ": 9.569751333342657, "Movement disorder ": 2.1368420258205894, "Multiple fractures ": 3.6000743399115893, "Muscular weakness ": 2.943874475443774, "Musculoskeletal chest pain ": 6.291496500752625, "Nephropathy ": 2.702581694389534, "Nephropathy toxic ": 6.925310611766496, "Osteomalacia ": 645.4999120606287, "Osteoporosis ": 7.13236119592556, "Pathogen resistance ": 7.553551912943149, "Pathological fracture ": 49.06039601632977, "Product complaint ": 3.57557203930012, "Protein urine present ": 28.01542513836638, "Proteinuria ": 13.164315772820816, "Renal disorder ": 9.788483822973008, "Renal failure ": 2.164966829025518, "Renal function test abnormal ": 23.30656627631284, "Renal glycosuria ": 1245.135526670312, "Renal impairment ": 15.278515022120454, "Renal tubular acidosis ": 57.90662626641055, "Renal tubular disorder ": 98.07129314915124, "Renal tubular dysfunction ": 103.9915162946266, "Rib fracture ": 16.381379774631004, "Spinal compression fracture ": 9.72577058560791, "Therapeutic response decreased ": 8.233763100962967, "Therapy non-responder ": 2.715086410649297, "Tibia fracture ": 18.285661805768235, "Transaminases increased ": 2.0754970308692737, "Tubulointerstitial nephritis ": 6.974678317951045, "Urine calcium increased ": 170.04222116763145, "Urine phosphorus increased ": 1118.0887978753017, "Viral infection ": 3.203725538308833, "Viral load increased ": 73.73402075593185, "Viral mutation identified ": 52.85393391499872, "Virologic failure ": 12.064851630748649} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/527.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/527.json new file mode 100644 index 00000000000..100561bd49c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/527.json @@ -0,0 +1 @@ +{"Abdominal pain ": 3.9519428340301377, "Drug interaction ": 6.361007207976812, "Overdose ": 4.36787360081528} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/528.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/528.json new file mode 100644 index 00000000000..3586c743bb8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/528.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 5.563235931985917, "Alopecia ": 2.758326892691253, "Alopecia areata ": 5.853647743634364, "Aortitis ": 19.790133136971345, "Blood lactate dehydrogenase increased ": 2.124833871112354, "Blood magnesium decreased ": 4.846376007144799, "Breast cancer metastatic ": 10.083868526044066, "Breast cancer recurrent ": 30.195068805959075, "Cardiac disorder ": 2.871957835538458, "Cardiac dysfunction ": 74.86613243387622, "Cardiac failure ": 14.30394070145912, "Cardiac failure acute ": 7.144756622736439, "Cardiac failure congestive ": 2.782964151357341, "Cardiomyopathy ": 14.65855317058424, "Cardiotoxicity ": 33.84908456206, "Dermatitis acneiform ": 4.6161009540491165, "Diarrhoea ": 3.973989721985364, "Dilated cardiomyopathy ": 8.500444015601486, "Disease progression ": 7.698146774538394, "Dry skin ": 2.423594277497117, "Ejection fraction abnormal ": 12.262746213510905, "Ejection fraction decreased ": 86.36710166560017, "Febrile neutropenia ": 7.358378751322185, "Granulocyte count decreased ": 8.519913535980328, "Granulocytopenia ": 4.195554295358837, "HER2 positive breast cancer ": 100.46124334043576, "Hair colour changes ": 5.160034083773915, "Hair texture abnormal ": 9.952475578000737, "Hepatic function abnormal ": 2.030584157575595, "Hypersensitivity ": 2.044519844185695, "Hypertransaminasaemia ": 4.0855247386006255, "Ill-defined disorder ": 2.488874156373861, "Infusion related reaction ": 13.78088985863785, "Intentional product use issue ": 2.451642646884129, "Interstitial lung disease ": 6.659204131341141, "Lacrimation increased ": 2.6089338111470703, "Left ventricular dysfunction ": 15.078983352772816, "Leukopenia ": 2.0095230153048336, "Lung infiltration ": 3.122007351119766, "Lymphoedema ": 7.097262975626716, "Lymphoma ": 2.0960493033904832, "Madarosis ": 20.146285544475266, "Mass ": 2.654234136363378, "Metastases to bone ": 8.710863335773325, "Metastases to central nervous system ": 29.56260290571279, "Metastases to liver ": 7.591623934907175, "Metastases to lung ": 7.084990561471039, "Metastases to lymph nodes ": 7.10243917847237, "Metastasis ": 4.809965350308519, "Metastatic neoplasm ": 14.712173388250616, "Mitral valve incompetence ": 5.941691618514279, "Mucosal inflammation ": 8.114971067489925, "Myelosuppression ": 18.18597533459476, "Nail disorder ": 11.556539537691254, "Neoplasm ": 3.380014602364869, "Neuropathy peripheral ": 6.444814337837478, "Neutropenia ": 3.314175636219788, "Neutrophil count decreased ": 8.998534002119026, "No adverse event ": 2.3075808163853666, "Oligohydramnios ": 7.314465437185395, "Onychoclasis ": 9.586571978680464, "Oxygen saturation decreased ": 2.0195810231110745, "Palmar-plantar erythrodysaesthesia syndrome ": 2.8090431608328625, "Paronychia ": 8.513438932237628, "Pericardial effusion ": 3.5529399031931543, "Peripheral sensory neuropathy ": 3.854672781068957, "Platelet count decreased ": 4.771354433435741, "Pleural effusion ": 3.846065370159309, "Pneumocystis jirovecii pneumonia ": 2.172956973179268, "Pneumonitis ": 4.936085658016009, "Polyneuropathy ": 3.995612132084032, "Pregnancy ": 4.709416242581648, "Pulmonary fibrosis ": 2.1951484717100342, "Recurrent cancer ": 12.4395004226943, "Red blood cell count decreased ": 2.6331414665676496, "Skin fissures ": 3.87366899550238, "Stomatitis ": 2.890219508815301, "Temperature intolerance ": 5.6878798243618585, "Therapy partial responder ": 3.295312851944208, "Tumour lysis syndrome ": 4.192336474724116, "White blood cell count decreased ": 6.7191966983459785} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/529.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/529.json new file mode 100644 index 00000000000..df1cd92c37e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/529.json @@ -0,0 +1 @@ +{"Diarrhoea ": 2.778330915051903, "Neutropenia ": 10.413710447962572, "Thrombocytopenia ": 5.796019187059625} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/53.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/53.json new file mode 100644 index 00000000000..8f72d19c99d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/53.json @@ -0,0 +1 @@ +{"Drug ineffective ": 3.599878987336271, "Product use in unapproved indication ": 21.375050404928874} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/530.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/530.json new file mode 100644 index 00000000000..87315fd9c1c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/530.json @@ -0,0 +1 @@ +{"Body temperature increased ": 10.32958251899102, "Crying ": 92.71839472572414, "Decreased appetite ": 4.664113215875697, "Diarrhoea ": 2.006424343382077, "Hypotonic-hyporesponsive episode ": 271.509093342318, "Irritability ": 15.450146402249551, "Pyrexia ": 3.333429449267536, "Restlessness ": 15.067242250313717} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/531.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/531.json new file mode 100644 index 00000000000..3f2a183e86b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/531.json @@ -0,0 +1 @@ +{"Allergy to metals ": 610.2763127030163, "Apathy ": 8.161867337607076, "Child maltreatment syndrome ": 3416.1109959636137, "Crying ": 27.844182582473746, "Cyanosis ": 11.405362204928052, "Erythema ": 2.038549033654611, "Febrile convulsion ": 53.758907140888994, "Hyperpyrexia ": 169.63819112844877, "Hypotonia ": 14.955513028298991, "Hypotonic-hyporesponsive episode ": 100.34455324278557, "Irritability ": 7.458123195875359, "Neurodermatitis ": 101.14428493815488, "Opisthotonus ": 109.67758439435184, "Pallor ": 13.751735599676266, "Pyrexia ": 4.872707947582511, "Reaction to excipient ": 158.01937603946033, "Restlessness ": 14.785980249796228, "Scratch ": 248.62180176241336, "Screaming ": 68.83905875963742, "Skin wound ": 634.1460256189082, "Sleep disorder ": 5.602653087644858, "Sudden infant death syndrome ": 234.6567004896544, "Unresponsive to stimuli ": 6.37297324703269, "Urticaria ": 4.1897069741485575, "Vaccination site discolouration ": 260.6918853920437, "Vaccination site eczema ": 551.143739752107, "Vaccination site erythema ": 14.862515432037831, "Vaccination site granuloma ": 1511.2063477437218, "Vaccination site hypertrichosis ": 1036.1351899356696, "Vaccination site hypertrophy ": 1777.208906920939, "Vaccination site irritation ": 229.8750314901758, "Vaccination site pruritus ": 35.2598687676903, "Vaccination site rash ": 19.683592590916295, "Vaccination site swelling ": 7.553123867549315} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/532.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/532.json new file mode 100644 index 00000000000..019ce270081 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/532.json @@ -0,0 +1 @@ +{"Abscess ": 2.528086955448713, "Administration site erythema ": 8.922399275127102, "Administration site reaction ": 19.77842550969847, "Adverse reaction ": 2.6565860649088613, "Atypical pneumonia ": 10.291454376890655, "Bacterial infection ": 3.2044479059391437, "Blood immunoglobulin G decreased ": 36.27031361807778, "Bronchiectasis ": 3.532536809394802, "Bronchitis ": 7.538495760177081, "Cardiac operation ": 4.95932656514605, "Catheterisation cardiac ": 5.835808709415831, "Cellulitis ": 5.166008982974264, "Chemotherapy ": 9.502185639318814, "Cholecystectomy ": 6.668405516410621, "Chronic inflammatory demyelinating polyradiculoneuropathy ": 58.07516676876715, "Chronic obstructive pulmonary disease ": 2.6881019632280445, "Clostridium difficile infection ": 3.743072382185313, "Cystitis ": 2.402208281316053, "Diverticulitis ": 3.3385121933344437, "Ear infection ": 9.069595599427752, "Escherichia infection ": 5.26026880475716, "Eye infection ": 5.559984873022812, "Fungal infection ": 2.010865237939614, "Gastric infection ": 13.862621940632469, "Gastroenteritis viral ": 5.274418581368087, "Hepatitis B ": 9.958667306868112, "Hepatitis B core antibody positive ": 38.189111717167016, "Hepatitis B surface antibody positive ": 51.77164990739778, "Hepatitis B virus test positive ": 50.52758032331322, "Hospitalisation ": 3.655486723706253, "Ill-defined disorder ": 3.579308857100964, "Immunoglobulins decreased ": 33.738866848222536, "Incorrect drug administration rate ": 7.367623049050164, "Infection ": 4.452126040231827, "Infusion site abscess ": 446.1142005373127, "Infusion site bruising ": 442.32685632151816, "Infusion site cellulitis ": 240.237802580342, "Infusion site discharge ": 309.9111977950611, "Infusion site discolouration ": 109.28780419841054, "Infusion site erythema ": 219.9994685294065, "Infusion site extravasation ": 15.37860710175936, "Infusion site haemorrhage ": 109.82311609014116, "Infusion site induration ": 163.63267015910438, "Infusion site infection ": 116.33437722823396, "Infusion site inflammation ": 68.76974051101088, "Infusion site irritation ": 108.78686453360515, "Infusion site mass ": 170.6550307713755, "Infusion site nodule ": 992.904496928134, "Infusion site oedema ": 49.51602992480217, "Infusion site pain ": 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"Injection site rash ": 4.797894981870561, "Injection site swelling ": 2.43063618930381, "Injection site ulcer ": 19.73151133587743, "Injection site urticaria ": 7.536768900084261, "Insurance issue ": 30.638194974535697, "Intestinal obstruction ": 2.3160482482814104, "Kidney infection ": 10.667244022158858, "Knee operation ": 5.8288378240947525, "Laryngitis ": 2.7231604842193677, "Limb operation ": 7.896683055121838, "Liquid product physical issue ": 4.500303814138518, "Lower respiratory tract infection ": 2.6201207671526983, "Lymphoma ": 2.256366044162881, "Meningitis ": 4.4043238105405536, "Meningitis aseptic ": 42.02005390010969, "Migraine ": 2.5997491242597524, "Nephrolithiasis ": 4.9939794894243255, "No adverse event ": 47.4727639798165, "Osteomyelitis ": 3.664592450902416, "Pharyngeal swelling ": 2.3012153729172047, "Pharyngitis streptococcal ": 7.556099067877654, "Pneumonia ": 6.286132259623117, "Product dose omission issue ": 2.6656307343340377, "Product supply issue ": 6.8775119565018885, "Product use complaint ": 3.3341869728334395, "Productive cough ": 2.8428069051672966, "Pseudomonas infection ": 5.671568869839827, "Recalled product administered ": 34.97980577250664, "Respiratory syncytial virus infection ": 4.202987451343903, "Respiratory tract congestion ": 2.99776304786257, "Respiratory tract infection ": 21.701726261615917, "Sinus congestion ": 3.3844417600672063, "Sinus disorder ": 5.2703287194656205, "Sinus operation ": 58.83111044456636, "Sinusitis ": 15.21091654878596, "Skin infection ": 7.779624734117752, "Skin mass ": 2.5646149742877262, "Skin reaction ": 2.4085911803181643, "Spinal operation ": 6.173474807894262, "Sputum discoloured ": 4.471242491455896, "Staphylococcal infection ": 9.890603931125645, "Stent placement ": 5.323996691807925, "Streptococcal infection ": 9.918279237222045, "Surgery ": 4.645676131964215, "Suspected transmission of an infectious agent via product ": 90.52469828045076, "Therapy cessation ": 9.459249774535277, "Therapy change ": 11.00637861506064, "Therapy interrupted ": 20.138043522854318, "Throat tightness ": 2.7145609839018694, "Thrombosis ": 2.854015766676838, "Tooth abscess ": 6.940010287625394, "Tooth infection ": 4.314104281288132, "Transient ischaemic attack ": 2.064851381804484, "Unevaluable event ": 6.289373205270835, "Upper respiratory tract infection ": 8.368358491661287, "Urinary tract infection ": 3.164035086404197, "Urine output decreased ": 6.549645339925149, "Viral infection ": 4.502516505989992, "Weight fluctuation ": 10.59553145379274, "Wound infection ": 3.2654064625317405} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/533.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/533.json new file mode 100644 index 00000000000..5babef414de --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/533.json @@ -0,0 +1 @@ +{"Abscess limb ": 2.423970573245167, "Accident ": 5.134296090486663, "Accident at work ": 5.531772209135802, "Accidental underdose ": 57.48463044537778, "Addison's disease ": 3.133679690100156, "Amputation ": 10.009123883071144, "Aneurysm ": 3.5631461382820944, "Angiopathy ": 2.959117705276686, "Animal bite ": 5.502912499872712, "Ankle fracture ": 3.3332642325989776, "Anti-insulin antibody ": 43.08463888836064, "Anti-insulin antibody increased ": 45.96755765258344, "Anti-insulin antibody positive ": 44.50766885741264, "Apgar score low ": 2.0033998277186664, "Arterial disorder ": 2.588967014562717, "Arterial occlusive disease ": 6.249310017616688, "Arterial stenosis ": 4.0712360669832846, "Arteriovenous malformation ": 8.959727133086355, "Arthritis ": 3.2927484422081994, "Arthropod bite ": 2.278627136169689, "Astigmatism ": 2.738801515105753, "Autonomic neuropathy ": 3.8413768636772736, "Back disorder ": 3.3259737918441337, "Back injury ": 2.0551448998794077, "Barrett's oesophagus ": 3.39694587919068, "Blindness ": 12.932367505458654, "Blindness transient ": 2.1680635879104875, "Blindness unilateral ": 11.997009446823066, "Blood glucose abnormal ": 41.51751871314652, "Blood glucose decreased ": 61.93563622436351, "Blood glucose fluctuation ": 30.054909609116542, "Blood glucose increased ": 43.88325485232816, "Blood insulin increased ": 23.709868522952835, "Blood ketone body ": 27.731487781647367, "Blood ketone body increased ": 16.000397660333935, "Blood ketone body present ": 3.643675920057981, "Blood pressure abnormal ": 2.28910518880132, "Blood zinc decreased ": 27.84800049505192, "Brain injury ": 3.595874994391312, "Brain neoplasm ": 3.75165265767888, "Brain neoplasm benign ": 13.16984413643266, "Cardiac disorder ": 4.054980977755793, "Cardiac failure congestive ": 3.449788401241661, "Cardiac valve disease ": 3.116608973153407, "Carotid artery occlusion ": 5.610036303401736, "Carpal tunnel syndrome ": 4.593000472920966, "Cataract ": 9.839782553755816, "Cerebral disorder ": 3.457213742481981, "Cerebrovascular accident ": 4.379197878243405, "Cervical vertebral fracture ": 3.620615356046761, "Chronic obstructive pulmonary disease ": 2.071451752506519, "Colon cancer ": 2.863102979249037, "Coma ": 2.470026658115763, "Concussion ": 2.6416962926804564, "Coronary artery bypass ": 2.5464972087956617, "Coronary artery disease ": 2.65238476180101, "Coronary artery occlusion ": 3.982714921896443, "Cutaneous amyloidosis ": 55.943347784993016, "Dawn phenomenon ": 51.44004911211495, "Deafness unilateral ": 2.97294524011579, "Dementia ": 6.70026152103368, "Dementia Alzheimer's type ": 9.090033673300798, "Diabetes mellitus inadequate control ": 14.30079560171121, "Diabetic blindness ": 85.2915186896516, "Diabetic coma ": 28.60281995299111, "Diabetic complication ": 35.37550111586806, "Diabetic eye disease ": 32.44745844754265, "Diabetic foot ": 23.94745638444631, "Diabetic foot infection ": 12.773037820135862, "Diabetic gangrene ": 21.28346852925818, "Diabetic gastroparesis ": 21.033150799084908, "Diabetic hyperglycaemic coma ": 22.078109391635746, "Diabetic ketoacidosis ": 19.34999277705633, "Diabetic ketoacidotic hyperglycaemic coma ": 18.37649268819292, "Diabetic ketosis ": 8.862039809632307, "Diabetic metabolic decompensation ": 3.312638011997777, "Diabetic nephropathy ": 10.163761874487356, "Diabetic neuropathy ": 18.282970033246286, "Diabetic retinopathy ": 51.53453526429638, "Drug hypersensitivity ": 2.281798921261733, "Drug ineffective ": 2.281226949699549, "Expired product administered ": 8.425817092861745, "Exposure via breast milk ": 2.807930018753666, "Extra dose administered ": 3.215002925208073, "Eye disorder ": 5.44849776292134, "Eye haemorrhage ": 17.461212754937904, "Eye injury ": 3.809969923747053, "Eye laser surgery ": 12.728311454621153, "Eye operation ": 2.9594184603574747, "Face injury ": 2.2148289353621884, "Fall ": 3.032765396243481, "Fat tissue increased ": 4.6365249166886455, "Feeding disorder ": 2.239621408551056, "Feeling abnormal ": 2.0173551651203496, "Femur fracture ": 2.505115008597845, "Fine motor skill dysfunction ": 2.6415203236234994, "Food poisoning ": 3.091107502744825, "Foot fracture ": 2.2030633807493145, "Gait inability ": 2.161026674735167, "Gangrene ": 9.007006637029564, "Gastroenteritis viral ": 2.176071078518933, "Gestational hypertension ": 3.919646916994599, "Glaucoma ": 7.70953006500159, "Glucose-6-phosphate dehydrogenase deficiency ": 95.23771580825802, "Glycosylated haemoglobin abnormal ": 9.749623360669291, "Glycosylated haemoglobin decreased ": 6.058077322015009, "Glycosylated haemoglobin increased ": 30.898597816481185, "Head injury ": 3.5914285189349053, "Hepatitis A ": 16.22729603318962, "Hernia ": 2.6288768182658497, "Herpes simplex ": 3.045355627835913, "Hip fracture ": 3.4040746331742224, "Humerus fracture ": 2.309384445238891, "Hunger ": 5.660684758757535, "Hypercoagulation ": 2.9039535676329997, "Hyperglycaemia ": 12.63845637842158, "Hyperglycaemic unconsciousness ": 39.040399199190375, "Hyperinsulinaemic hypoglycaemia ": 60.11258375732549, "Hyperkeratosis ": 2.3334183386466307, "Hypermetropia ": 2.9411069982300866, "Hypoacusis ": 4.181570700584396, "Hypoglycaemia ": 23.835807177441875, "Hypoglycaemia neonatal ": 7.402147314719574, "Hypoglycaemia unawareness ": 81.60970471558056, "Hypoglycaemic coma ": 26.64737693109664, "Hypoglycaemic encephalopathy ": 9.389388590552498, "Hypoglycaemic seizure ": 38.83323533030466, "Hypoglycaemic unconsciousness ": 38.73787878089617, "Hypophagia ": 2.138261525220665, "Illness ": 2.417163991948005, "Impaired gastric emptying ": 6.906755723416346, "Impaired healing ": 2.2494946416641057, "Incoherent ": 2.6164135954225056, "Incorrect dosage administered ": 5.079578110604515, "Incorrect dose administered ": 17.720115081805087, "Incorrect product administration duration ": 9.035979882442422, "Incorrect product dosage form administered ": 7.7615260384409615, "Incorrect product formulation administered ": 25.88890783753506, "Increased insulin requirement ": 14.366962285987526, "Infarction ": 2.0355116500414003, "Infusion site infection ": 6.38068917777827, "Injection site atrophy ": 5.540786619491613, "Injection site bruising ": 7.220277265172006, "Injection site haemorrhage ": 5.516411457802968, "Injection site hypersensitivity ": 3.574980948566243, "Injection site infection ": 2.6274436113433217, "Injection site injury ": 5.367992592604903, "Injection site irritation ": 2.584536848938182, "Injection site mass ": 5.3933389154404345, "Injection site scar ": 13.947291957017791, "Injection site urticaria ": 4.409697891694683, "Injury associated with device ": 14.483456703818993, "Insulin C-peptide decreased ": 30.74465337518028, "Insulin resistance ": 57.62930720467428, "Insulin resistant diabetes ": 78.20262167219502, "Intercepted product dispensing error ": 52.15020285167839, "Intercepted product selection error ": 104.3391302207189, "Intervertebral disc degeneration ": 2.2486722254043072, "Intervertebral disc protrusion ": 2.97393137794468, "Intracranial aneurysm ": 2.02433350206806, "Jaundice neonatal ": 3.385428116203092, "Joint injury ": 3.1752238367787284, "Ketoacidosis ": 13.481705582495389, "Ketonuria ": 5.066176920903752, "Ketosis ": 10.904758441045582, "Large for dates baby ": 18.649890323998875, "Leg amputation ": 5.516518080632216, "Ligament disorder ": 8.466224930517543, "Ligament rupture ": 2.0414072396363627, "Limb deformity ": 2.2501366278233483, "Limb injury ": 6.068354649300743, "Lip injury ": 3.503806135454594, "Lipids increased ": 2.873277170397168, "Lipoatrophy ": 7.627500257782525, "Lipohypertrophy ": 5.723343559366875, "Lipoma ": 2.9311809518849734, "Localised infection ": 7.845262910914044, "Loss of consciousness ": 3.46907131798296, "Lower limb fracture ": 4.079368559392479, "Macular degeneration ": 6.873135908429041, "Macular oedema ": 4.321691850946753, "Maculopathy ": 2.8347756652507394, "Malabsorption from injection site ": 48.65424171960977, "Malnutrition ": 10.113088864055069, "Medication error ": 3.285766161547184, "Memory impairment ": 4.055099621342925, "Meniscus injury ": 2.4132122228082467, "Microalbuminuria ": 18.042749946604467, "Multi-organ disorder ": 49.34177021652342, "Musculoskeletal disorder ": 2.0102312679837926, "Myocardial infarction ": 3.3307101858068573, "Myopia ": 3.4181106878652328, "Neck injury ": 5.253712110222016, "Neoplasm malignant ": 2.701503050793737, "Neovascular age-related macular degeneration ": 3.593824546640325, "Nerve compression ": 3.869279632810292, "Nerve injury ": 3.1429455018269894, "Neuropathic arthropathy ": 41.50460065641253, "Neuropathy peripheral ": 3.867009751120541, "Nonspecific reaction ": 3.319821636926553, "Nosocomial infection ": 2.330788457325879, "Osteomyelitis ": 6.063820391767351, "Overweight ": 4.3363732384206175, "Pancreatic abscess ": 17.145873204941108, "Pancreatic disorder ": 11.37197562329227, "Pancreatic failure ": 7.267595990314433, "Parkinson's disease ": 3.8719616118628535, "Patella fracture ": 2.8024408704587014, "Pelvic fracture ": 2.977328031505329, "Pericardial effusion ": 3.070549191432192, "Peripheral artery occlusion ": 3.456858238818632, "Peripheral vascular disorder ": 2.024454419421392, "Pollakiuria ": 2.106559315281079, "Poor peripheral circulation ": 5.702083194997125, "Poor quality product administered ": 3.0793215704199075, "Post procedural complication ": 4.741386534633255, "Post procedural infection ": 3.6401411605545406, "Postoperative wound infection ": 3.2183765536974045, "Postprandial hypoglycaemia ": 16.0670790429748, "Pre-eclampsia ": 4.591116386320009, "Premature baby ": 2.491856840522042, "Premature labour ": 2.218312926312457, "Presbyopia ": 6.14435445555031, "Product administration error ": 2.087105649241942, "Product dispensing error ": 6.752393443766357, "Product dose omission issue ": 6.184390448022632, "Product name confusion ": 10.606230974206628, "Product storage error ": 14.61816584765003, "Product tampering ": 19.2821272710958, "Prostatic disorder ": 2.230458706492033, "Pulmonary oedema ": 2.6133288243702224, "Rectal cancer ": 2.052474809502654, "Renal disorder ": 5.050404347458047, "Renal transplant ": 4.1229021445149785, "Retinal detachment ": 8.587443620426185, "Retinal disorder ": 10.52188030825366, "Retinal haemorrhage ": 5.029611148245983, "Retinal injury ": 9.023996745198552, "Retinal tear ": 5.77192100095002, "Retinopathy ": 14.154944278469465, "Rhinitis allergic ": 2.931694052766853, "Rib fracture ": 2.152843009152915, "Road traffic accident ": 7.132725347175257, "Rotator cuff syndrome ": 2.913511354310729, "Scar ": 2.944494538549733, "Shock hypoglycaemic ": 31.95233324724992, "Shoulder fracture ": 5.059821612431992, "Skin ulcer ": 2.8211535741436213, "Sleep apnoea syndrome ": 2.531347065786174, "Snoring ": 7.89045088823018, "Sopor ": 7.000230499893152, "Spinal column injury ": 3.457693431630662, "Spinal disorder ": 2.1759357036878173, "Spinal stenosis ": 3.14089492460239, "Staphylococcal infection ": 2.305646006901139, "Stress ": 4.736833351745925, "Suspected transmission of an infectious agent via product ": 8.472359952967983, "Therapeutic product effect delayed ": 6.786308042721581, "Therapeutic product effect increased ": 2.337830126489203, "Therapeutic response delayed ": 9.70174829135984, "Thirst ": 2.5035340959028383, "Throat cancer ": 2.484660999749372, "Thyroid disorder ": 6.992386315099293, "Toe amputation ": 7.326867014125879, "Trigger finger ": 15.33770460523214, "Underdose ": 5.2565795328222205, "Upper limb fracture ": 2.146620976444429, "Urine ketone body present ": 10.572806907627688, "Vascular graft ": 4.523296790439978, "Vascular occlusion ": 8.354291217511173, "Vein disorder ": 2.242360424173966, "Venous occlusion ": 2.2699825726523666, "Visual acuity reduced ": 2.261790204874336, "Visual impairment ": 6.828254123474561, "Vitreous haemorrhage ": 3.656538496811119, "Weight abnormal ": 4.975809372949913, "Weight decreased ": 2.250498445144471, "Weight increased ": 2.6773538754108523, "Wound complication ": 2.2373073071702367, "Wound infection ": 3.0540353567091656, "Wrong patient received product ": 7.187099223907235, "Wrong product administered ": 26.60076480993916, "Wrong technique in product usage process ": 3.7549919374923535} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/534.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/534.json new file mode 100644 index 00000000000..8c324b25f63 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/534.json @@ -0,0 +1 @@ +{"Acute respiratory distress syndrome ": 2.9741158127953558, "Anaphylactic reaction ": 3.353627510609788, "Anaphylactoid reaction ": 9.077106355714786, "Anti factor VIII antibody positive ": 25.0229386184022, "Autoimmune haemolytic anaemia ": 14.266866150918984, "Bacteraemia ": 3.035931942615503, "Blood immunoglobulin G decreased ": 42.224203467572615, "Cardiogenic shock ": 2.352980698783336, "Coombs direct test positive ": 99.2069815265432, "Coronary artery aneurysm ": 125.62785344549354, "Cytomegalovirus infection ": 3.6848678315302, "Cytomegalovirus viraemia ": 7.990011173139972, "Deep vein thrombosis ": 2.500717685911884, "Dermatomyositis ": 10.006971464587856, "Disseminated intravascular coagulation ": 2.753045517383419, "Drug effective for unapproved indication ": 131.82840939780604, "Drug ineffective ": 5.722882319457908, "Drug ineffective for unapproved indication ": 107.69859318424828, "Drug resistance ": 5.150330505175726, "Dyshidrotic eczema ": 27.70027244521391, "Ear infection ": 3.5547058331081307, "Embolism ": 5.035406269515918, "Encephalitis ": 2.34549498838168, "Encephalitis autoimmune ": 11.298858648130482, "Epstein-Barr virus infection ": 4.6300469987518245, "Exposure during pregnancy ": 5.484184694915429, "Febrile nonhaemolytic transfusion reaction ": 82.12769403328932, "Foetal death ": 5.025831028697945, "Foetal exposure during pregnancy ": 4.790408728040396, "Foetal growth restriction ": 4.527883398263985, "Guillain-Barre syndrome ": 2.1335010644205, "Haemolysis ": 41.31251147247692, "Haemolytic anaemia ": 34.38749880849628, "Hemianopia homonymous ": 29.070209625223576, "Hepatitis B core antibody positive ": 43.11138032909053, "Hepatitis B surface antibody positive ": 55.46440502694127, "Hepatitis C ": 5.800916360538624, "Hypervolaemia ": 3.723911452673895, "Hypoxia ": 3.014060738086456, "Incorrect drug administration rate ": 18.415175313121495, "Infusion related reaction ": 2.6396432445734037, "Infusion site bruising ": 55.42009141406299, "Infusion site erythema ": 15.62718382716889, "Infusion site haemorrhage ": 69.15047975926672, "Infusion site pain ": 13.520994382603185, "Infusion site pruritus ": 24.884685448179056, "Intentional product use issue ": 9.49510192876428, "Ischaemic stroke ": 2.221641593992576, "Low birth weight baby ": 5.652287105920948, "Lupus-like syndrome ": 5.220276887316385, "Maternal exposure during pregnancy ": 3.2685919883204533, "Meningitis ": 3.0835514355770166, "Meningitis aseptic ": 102.35111657517828, "Misleading laboratory test result ": 442.7832890143675, "Multiple-drug resistance ": 11.08506671796665, "Myasthenia gravis ": 3.788017304848753, "Myositis ": 3.288561023640566, "Nephrotic syndrome ": 2.5153676693698848, "No adverse event ": 36.92807322490231, "Off label use ": 6.827542073059044, "Post procedural complication ": 5.889679632824693, "Posterior reversible encephalopathy syndrome ": 18.32105427120659, "Premature baby ": 5.091361208179787, "Premature delivery ": 2.3316607742190696, "Product use in unapproved indication ": 6.252972121762179, "Pulmonary embolism ": 2.998688500984221, "Respiratory distress ": 2.239396214724424, "Respiratory failure ": 2.1874171648282084, "Respiratory tract infection ": 2.5052957476922595, "Status epilepticus ": 3.756317920150319, "Stress cardiomyopathy ": 4.837802516709411, "Suspected counterfeit product ": 7.1070799062503545, "Tachypnoea ": 3.6129081772202407, "Therapeutic product effect incomplete ": 15.46923099115426, "Therapeutic response unexpected ": 11.606294007150304, "Therapy interrupted ": 3.219678766075916, "Therapy non-responder ": 13.877412348139584, "Therapy partial responder ": 14.333179066830636, "Toxic epidermal necrolysis ": 2.589178816128908, "Transfusion-related acute lung injury ": 196.10301491211683, "Transfusion-related circulatory overload ": 231.92152943682197} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/535.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/535.json new file mode 100644 index 00000000000..6767b3a1471 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/535.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 4.089612509281598, "Abscess ": 6.908129252415575, "Acne ": 3.072057412892482, "Acute myocardial infarction ": 2.1083863218627625, "Adverse drug reaction ": 5.371628118115433, "Alanine aminotransferase abnormal ": 4.053585271267126, "Amputation ": 8.850896569739021, "Anal abscess ": 4.236894888333481, "Anal fissure ": 10.3175946154638, "Anal fistula ": 26.707534798010467, "Anal incontinence ": 3.516115873283779, "Animal bite ": 11.202214953071064, "Ankylosing spondylitis ": 11.47384731780143, "Anti-cyclic citrullinated peptide antibody ": 11.757513015983667, "Aphthous ulcer ": 2.023821222211253, "Arthritis ": 5.672546780484407, "Arthritis bacterial ": 6.066129117527454, "Arthritis infective ": 6.003757215095779, "Arthrodesis ": 8.826519533944474, "Arthropathy ": 2.630172971784552, "Arthropod bite ": 2.992104373090342, "Basal cell carcinoma ": 2.140917785821056, "Bladder transitional cell carcinoma ": 17.096688236784093, "Blood creatinine decreased ": 5.162526622884266, "Blood iron decreased ": 2.1522918297716678, "Bowel movement irregularity ": 6.146801776798209, "Bursitis ": 2.7826611785405087, "C-reactive protein abnormal ": 2.036057716825601, "C-reactive protein decreased ": 34.479027743948826, "C-reactive protein increased ": 2.807075524235502, "Candida infection ": 2.8393002074381046, "Cardiac pacemaker insertion ": 3.767177563296787, "Carpal tunnel syndrome ": 3.300463452940652, "Cataract ": 2.7187448663556104, "Cerebral venous sinus thrombosis ": 2.3589205436024123, "Cervical vertebral fracture ": 4.391541358766919, "Cholangitis sclerosing ": 11.96702018756216, "Cholecystectomy ": 2.6857466399380754, "Chronic cutaneous lupus erythematosus ": 21.63308931377145, "Clavicle fracture ": 5.155421744503673, "Clostridium difficile infection ": 2.920838904437826, "Coeliac disease ": 2.6707378290782176, "Colectomy ": 9.086762356189515, "Colitis ": 3.597647153516079, "Colitis ulcerative ": 11.859736030009048, "Colon cancer ": 2.2826380856405364, "Contraindicated product administered ": 2.3824559836587555, "Coronary artery occlusion ": 2.1742283244188614, "Crohn's disease ": 18.85909146792432, "Cystic fibrosis ": 8.24993517984446, "Cystitis ": 6.0555362823051455, "Dactylitis ": 9.77396142544771, "Defaecation urgency ": 11.902482273665877, "Demyelination ": 9.925071282928124, "Dermatitis exfoliative generalised ": 2.3024452415661725, "Diarrhoea haemorrhagic ": 5.571032566826793, "Disability ": 3.281130647581377, "Disease complication ": 4.249903297783173, "Diverticular perforation ": 9.91732426285414, "Diverticulitis ": 2.080586039258766, "Diverticulum ": 2.385131762101803, "Drug hypersensitivity ": 6.48584573273197, "Drug ineffective ": 4.082529080195643, "Drug intolerance ": 5.6008762153665925, "Drug level abnormal ": 39.534305112580185, "Drug level decreased ": 9.181185550406468, "Drug specific antibody ": 9.931142126017075, "Drug specific antibody present ": 19.19326179103208, "Dyschezia ": 10.088663416404128, "Dyslipidaemia ": 2.332446140839369, "Enthesopathy ": 3.5526512434833557, "Exostosis ": 2.8454322894402546, "Eye disorder ": 2.6357066813848906, "Eye infection ": 2.686660698082731, "Eye injury ": 10.811378478596708, "Faecal calprotectin increased ": 40.01812721442777, "Faeces soft ": 12.464777516777728, "Feeling of despair ": 2.5193538712117736, "Fibromyalgia ": 5.479513820979863, "Finger deformity ": 3.78846375066755, "Fistula ": 16.805968862712607, "Fistula discharge ": 63.574617661321135, "Food allergy ": 4.736377243973619, "Food intolerance ": 4.430173283832537, "Foot deformity ": 4.500188227793121, "Foreign body embolism ": 631.1768025196184, "Foreign body in respiratory tract ": 36.11607921342855, "Frequent bowel movements ": 15.288560856269516, "Fungal infection ": 2.86110139676079, "Fungal skin infection ": 4.630624753968936, "Furuncle ": 4.98678226308189, "Gastrointestinal disorder ": 2.3552203378368177, "Gastrointestinal infection ": 4.693973515550377, "Gastrointestinal inflammation ": 7.916630964978486, "Gastrointestinal mucosa hyperaemia ": 67.50825723639898, "Gastrointestinal oedema ": 6.804568812232067, "Gastrointestinal toxicity ": 3.413917061674866, "General symptom ": 10.94581230412594, "Glomerular filtration rate abnormal ": 3.759555549185874, "Glucose tolerance impaired ": 6.6923583982254105, "Grip strength decreased ": 4.385045785005532, "Groin pain ": 3.379010458470165, "Haematochezia ": 3.02475368462139, "Hepatic fibrosis ": 3.169660866236496, "Hepatic steatosis ": 3.389562218203732, "Hepatitis B ": 2.2108138111033178, "Herpes simplex oesophagitis ": 360.22519557019314, "Hidradenitis ": 47.26125021553986, "Hodgkin's disease ": 4.637521360406151, "Hyperphagia ": 16.399832867299157, "Hysterectomy ": 2.8364282911160057, "Ileostomy ": 15.658315811925988, "Immunodeficiency ": 7.502544293224453, "Immunosuppression ": 4.704860484842739, "Impaired quality of life ": 7.238404263682648, "Impaired work ability ": 2.8296923124761046, "Infection ": 2.634797379235464, "Inflammation ": 5.2420571725315765, "Inflammatory bowel disease ": 6.7775644416693845, "Inflammatory marker increased ": 4.740294612246738, "Injection site bruising ": 2.715843135814292, "Intentional dose omission ": 4.108916592193777, "Intervertebral disc disorder ": 3.1509625233342105, "Intervertebral disc protrusion ": 6.057971659353998, "Intestinal anastomosis ": 53.996061640104784, "Intestinal obstruction ": 2.1372937451896123, "Intestinal perforation ": 3.56124689584405, "Intestinal resection ": 18.2590565790706, "Intestinal stenosis ": 10.185518702842876, "Intestinal ulcer ": 23.68398022720706, "Investigation abnormal ": 13.012915817241517, "Iron deficiency ": 5.088668436612184, "Joint effusion ": 5.2913138708851495, "Joint injury ": 6.441841189722935, "Joint noise ": 14.273851830983068, "Joint range of motion decreased ": 8.955495527909804, "Joint space narrowing ": 60.52690974700181, "Joint stiffness ": 6.534394169315148, "Joint swelling ": 4.133262471655464, "Juvenile idiopathic arthritis ": 10.59574221614061, "Knee arthroplasty ": 5.858604215554467, "Knee operation ": 4.66465344599152, "Laboratory test abnormal ": 3.322679119811636, "Laparotomy ": 15.011547619204594, "Large intestinal stenosis ": 28.132556905663627, "Large intestinal ulcer ": 4.804388682901338, "Leg amputation ": 3.4564480786839056, "Ligament sprain ": 2.303245571688715, "Limb injury ": 2.4999468389191617, "Limb operation ": 7.862596051523624, "Liver function test abnormal ": 2.5244614658908384, "Localised infection ": 2.0152842500579995, "Loss of personal independence in daily activities ": 3.773238221986897, "Lower limb fracture ": 2.150251795159507, "Lupus-like syndrome ": 18.619915298052817, "Lyme disease ": 4.07583105417339, "Lymphoma ": 2.097079132268074, "Malignant melanoma ": 2.1377954818542277, "Malnutrition ": 3.149603411883763, "Medical device implantation ": 19.37971712124573, "Middle insomnia ": 3.608948557418156, "Mobility decreased ": 2.344447401538378, "Mouth ulceration ": 2.1600167926373794, "Mucous stools ": 5.501050560822975, "Multiple sclerosis ": 2.41132944218718, "Muscle tightness ": 3.774451684556418, "Musculoskeletal disorder ": 3.4607610254680607, "Musculoskeletal pain ": 2.216274590322169, "Musculoskeletal stiffness ": 3.5404132279728797, "Myasthenia gravis ": 2.363821166964887, "Neck pain ": 2.437523999855325, "Nephrolithiasis ": 2.129548316573213, "Nerve compression ": 5.211818867345266, "Nodule ": 3.267719446534155, "Nonspecific reaction ": 12.478184811274156, "Nystagmus ": 2.1876247276139984, "Obstruction ": 7.703538013323878, "Ophthalmoplegia ": 5.966586871166773, "Oral herpes ": 2.809506000810029, "Osteoarthritis ": 6.177999485760927, "Pathogen resistance ": 4.906327159919575, "Peripheral swelling ": 2.487884987268813, "Pilonidal disease ": 57.69823251673791, "Polyarthritis ": 4.9212726473584345, "Polyp ": 3.88680408797094, "Poor peripheral circulation ": 2.25676995813038, "Poor venous access ": 9.52025137472416, "Post procedural complication ": 2.323409032475936, "Post procedural infection ": 8.60113055895309, "Post-traumatic pain ": 49.12310336964346, "Postoperative wound infection ": 2.762556371754778, "Pouchitis ": 40.0502155324284, "Procedural pain ": 4.2973966967318935, "Proctalgia ": 3.142974378260089, "Proctitis ": 2.8911605061076124, "Product contamination physical ": 19.590340374175348, "Product label issue ": 8.52569055747612, "Pseudomonas infection ": 2.792358891822872, "Psoriasis ": 13.291624687832163, "Psoriatic arthropathy ": 9.390486611940275, "Pulmonary pain ": 3.3658356911039164, "Pulmonary tuberculosis ": 4.447103881061256, "Pulmonary vasculitis ": 12.26730195400268, "Purulent discharge ": 4.092517919917436, "Pustular psoriasis ": 5.002281045411307, "Pyoderma gangrenosum ": 6.2125717917968535, "Rectal haemorrhage ": 3.072863500269261, "Red blood cell sedimentation rate decreased ": 39.534305112580185, "Red blood cell sedimentation rate increased ": 9.640759914309262, "Respiratory syncytial virus infection ": 3.1163406970770247, "Respiratory tract congestion ": 2.681413897117869, "Retinal toxicity ": 30.68886444324845, "Rheumatoid arthritis ": 9.252504710501295, "Rheumatoid factor positive ": 6.0941831963380535, "Root canal infection ": 251.5805299526095, "Rotator cuff syndrome ": 2.549712236589772, "Sacroiliitis ": 14.500019471821634, "Salt craving ": 252.3229399113025, "Scar ": 2.311254836593597, "Seasonal allergy ": 2.5029228499892966, "Sensitivity to weather change ": 3.897885747503868, "Seronegative arthritis ": 15.34781210291506, "Shoulder operation ": 6.222094698634703, "Sinus congestion ": 2.035908287864176, "Sinus disorder ": 2.2613387640202336, "Sinusitis ": 2.542782332680828, "Sinusitis bacterial ": 18.20069535634932, "Sjogren's syndrome ": 4.729415034644246, "Skin cancer ": 3.101425179814654, "Skin induration ": 3.733315474051074, "Skin lesion ": 2.221126364538839, "Skin mass ": 3.278395838909885, "Skin plaque ": 3.4030039781789445, "Skin reaction ": 2.029658386540922, "Small intestinal obstruction ": 3.6270668390388057, "Spinal osteoarthritis ": 4.695183799158509, "Spinal stenosis ": 2.072433350261212, "Spondylitis ": 6.5385834498678665, "Squamous cell carcinoma ": 3.144724524155957, "Squamous cell carcinoma of skin ": 2.5019819602299544, "Stenosis ": 12.002309282281534, "Steroid dependence ": 31.95986689950306, "Stress ": 4.363558512458579, "Subcutaneous abscess ": 5.361809609389688, "Surgery ": 2.337949304889748, "Swollen joint count increased ": 8.157357656832843, "Synovitis ": 12.420267993527448, "Systemic lupus erythematosus ": 2.3803388454852783, "Tachyarrhythmia ": 7.293448300319148, "Temperature regulation disorder ": 4.074407710586363, "Tenosynovitis ": 3.207516355186352, "Thalassaemia minor ": 200.9054819402286, "Therapeutic product effect decreased ": 12.583150218611037, "Therapeutic product effect incomplete ": 5.335488103230087, "Therapeutic response shortened ": 17.508444467131778, "Therapy partial responder ": 4.228867058271397, "Tooth abscess ": 7.954898425754529, "Transfusion reaction ": 27.951435803193966, "Treatment failure ": 3.66524652690179, "Trismus ": 2.3332881177629363, "Tuberculosis ": 5.43598098610374, "Type 1 diabetes mellitus ": 2.6441424246613408, "Type 2 diabetes mellitus ": 4.883950880247271, "Ulcer ": 4.788352124919284, "Unevaluable event ": 3.974716538591281, "Uterine polyp ": 9.233408654059543, "Uveitis ": 5.890106344139372, "Viral tonsillitis ": 249.33489495330292, "Vitamin D decreased ": 2.649990869289151, "White matter lesion ": 10.186417692743928, "Wound complication ": 11.67614370224807, "Wound dehiscence ": 6.408743296619674, "Wound secretion ": 4.921689536004323, "Wrist deformity ": 21.21109314334856} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/536.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/536.json new file mode 100644 index 00000000000..bb9b7e074fa --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/536.json @@ -0,0 +1 @@ +{"Agranulocytosis ": 2.2458824067425622, "Anaemia ": 13.81168275832488, "Blood alkaline phosphatase increased ": 3.106180453629597, "Blood bilirubin increased ": 2.9637077820045667, "Blood lactate dehydrogenase increased ": 7.454170133962839, "Blood sodium decreased ": 8.21096265461587, "Blood urea increased ": 5.375157798213568, "Bone marrow failure ": 8.994056512647528, "Death ": 5.825803702001005, "Decreased appetite ": 4.286295818718715, "Disease progression ": 4.088221527901891, "Febrile neutropenia ": 14.75578955889442, "Haematotoxicity ": 19.74903657799025, "Haemoglobin decreased ": 4.2356837408112336, "Ileus ": 10.828623647493885, "Interstitial lung disease ": 5.31336863781602, "Leukopenia ": 11.89923373865077, "Myelosuppression ": 5.49694849873427, "Neutropenia ": 7.038924877404578, "Neutrophil count decreased ": 37.82139309258236, "Pancytopenia ": 14.407835973075754, "Platelet count decreased ": 24.06033229321545, "Protein total decreased ": 39.56100020244674, "Red blood cell count decreased ": 59.5453019001828, "Sepsis ": 2.5976700428449946, "Small cell lung cancer ": 105.22367541660442, "Thrombocytopenia ": 8.223117850009672, "White blood cell count decreased ": 24.24588415432542} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/537.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/537.json new file mode 100644 index 00000000000..b273d4c572a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/537.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 5.384028878342408, "Angioedema ": 4.821075652509352, "Blood creatine phosphokinase increased ": 2.109052229109457, "Blood creatinine increased ": 4.936031143424768, "Blood pressure decreased ": 2.1469690517506748, "Blood pressure fluctuation ": 7.503337707575477, "Blood pressure increased ": 4.319102189370401, "Cataract ": 5.047155231959379, "Completed suicide ": 4.547487303790689, "Eye pain ": 4.479097198272771, "Hyperglycaemia ": 2.5795252685950327, "Hyperkalaemia ": 4.6060379624442, "Hypokalaemia ": 26.44071193552828, "Hyponatraemia ": 14.822155081241691, "Hypotension ": 4.691362883981481, "Intentional overdose ": 2.0235000204827176, "Liver function test abnormal ": 3.499071064472354, "Oedema peripheral ": 2.47609353786058, "Product substitution issue ": 16.203726705119042, "Renal impairment ": 5.410987786738501, "Restlessness ": 2.075349399758765, "Stevens-Johnson syndrome ": 5.435724155453702, "Suicide attempt ": 2.6614860996521035, "Swelling face ": 3.839674414283453, "Systemic lupus erythematosus ": 4.660739266470458, "Therapeutic response unexpected ": 4.561638438198443, "Toxicity to various agents ": 3.388301594537451, "Urinary tract infection ": 2.2699568972014603, "Vision blurred ": 2.686706493226288} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/538.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/538.json new file mode 100644 index 00000000000..a1c6cabbd51 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/538.json @@ -0,0 +1 @@ +{"Acute respiratory distress syndrome ": 2.1424906772319168, "Acute respiratory failure ": 2.442643023124855, "Adrenal insufficiency ": 21.786673113041044, "Adrenal suppression ": 80.51600253342541, "Adrenocortical insufficiency acute ": 47.97235498325499, "Adverse drug reaction ": 2.2134298841100817, "Angiopathy ": 13.063279941254985, "Apnoea ": 5.681993997346934, "Aspergillus infection ": 5.765697820335313, "Asthmatic crisis ": 3.7077742899266433, "Auditory disorder ": 11.130338020192449, "Bacteraemia ": 3.798089633585603, "Blood bicarbonate decreased ": 12.969970740445046, "Blood lactic acid increased ": 5.0071046681924125, "Blood pH decreased ": 14.501248754679011, "Blood potassium decreased ": 2.4602424420280644, "Body temperature fluctuation ": 9.525873603337748, "Bone disorder ": 4.187236907389356, "Bronchiectasis ": 10.235221294369191, "Bronchospasm ": 2.039325425910312, "Burning sensation ": 3.305793005749032, "Caesarean section ": 6.668218368323991, "Calcinosis ": 34.185383932214165, "Cardiomegaly ": 3.627989986137317, "Cataract ": 3.04694164686073, "Central obesity ": 37.5807670380101, "Cerebral disorder ": 17.567016299061585, "Clonus ": 10.81897970251229, "Colitis ulcerative ": 2.0136206462918618, "Condition aggravated ": 2.3490571979750725, "Cortisol decreased ": 27.446090241778634, "Craniocerebral injury ": 16.107018054627154, "Crepitations ": 8.618088568997015, "Cushing's syndrome ": 33.789931168865145, "Cushingoid ": 8.839438022693637, "Decreased interest ": 29.50955484596742, "Dermatitis ": 2.944932120808041, "Dermatitis atopic ": 9.034436489467485, "Dermatitis bullous ": 3.962940278076703, "Device dislocation ": 52.529716803804256, "Device malfunction ": 9.124717752478968, "Disease recurrence ": 4.369353163680615, "Disseminated intravascular coagulation ": 2.2491161818492844, "Diverticulum ": 5.198682800146693, "Drug hypersensitivity ": 2.152735140128359, "Drug ineffective ": 2.577950327990197, "Drug interaction ": 2.152182351230056, "Drug level increased ": 2.15012736949981, "Dry skin ": 2.5700438672489736, "Duodenal ulcer perforation ": 2.440794762166317, "Dysuria ": 3.5569242428419865, "Ear infection ": 2.8365113084518776, "Eczema ": 7.207423631085216, "Electroencephalogram abnormal ": 6.242262733660415, "Emotional disorder ": 3.261860886260139, "Erythema ": 2.7268610672384224, "Exposure during pregnancy ": 3.111906826090044, "Eye swelling ": 2.527822239397661, "Flushing ": 2.610534132611916, "Foetal death ": 6.00608723800146, "Foetal exposure during pregnancy ": 2.379052348017592, "Foetal growth restriction ": 3.007923239590444, "Fungal infection ": 3.5296089246069364, "Gingival disorder ": 30.727243669486285, "Growth retardation ": 8.08080788756608, "Hip arthroplasty ": 5.247101754103886, "Hypercapnia ": 14.751160631951256, "Hypercholesterolaemia ": 3.2245078471824704, "Hyperventilation ": 3.053036580347279, "Hypoacusis ": 3.279165838952511, "Hypocalcaemia ": 2.3939519173738706, "Hypomagnesaemia ": 3.821049958365553, "Hypophosphataemia ": 9.88939523519174, "Hypothalamic pituitary adrenal axis suppression ": 137.89566713230414, "Incorrect product administration duration ": 2.0664840836190974, "Incorrect route of product administration ": 2.4767807809314366, "Inflammation ": 2.6001489732830843, "Knee arthroplasty ": 6.292799886246887, "Lip swelling ": 2.785069484812841, "Lipase increased ": 3.4920478303509577, "Live birth ": 10.80564277732502, "Lung hyperinflation ": 34.42613259308436, "Maternal exposure during pregnancy ": 3.014403411871577, "Medication error ": 5.173922249640948, "Metabolic acidosis ": 2.072632917201095, "Mobility decreased ": 2.9660269887826183, "Multiple organ dysfunction syndrome ": 4.937040480149458, "Multiple-drug resistance ": 6.838664909761753, "Nerve compression ": 20.805389158093075, "Neuralgia ": 5.3206100426639455, "Obstructive airways disorder ": 2.239139349366045, "Oedema ": 2.6393992151435755, "Oral disorder ": 13.173859414567607, "Osteoarthritis ": 2.1989195427880563, "Oxygen saturation decreased ": 2.0839877497959094, "PCO2 increased ": 42.12694531530786, "PO2 decreased ": 28.430124957901445, "Pain of skin ": 3.547850538933444, "Perfume sensitivity ": 114.31224896336468, "Perineal pain ": 114.3506496984886, "Peripheral coldness ": 3.55626541674488, "Peripheral venous disease ": 6.344541821465205, "Pituitary tumour benign ": 18.686926283494053, "Post procedural infection ": 10.70054335585496, "Premature baby ": 5.016327798363761, "Premature delivery ": 9.296888917729335, "Premature labour ": 5.779270125947948, "Preterm premature rupture of membranes ": 105.9744567718501, "Quality of life decreased ": 3.322878404175163, "Radiculopathy ": 12.761698742674035, "Rash pruritic ": 2.190773027960508, "Respiratory acidosis ": 10.074876529457978, "Respiratory arrest ": 2.9870040819133936, "Respiratory depression ": 2.33978335419846, "Respiratory disorder ": 4.951970720157633, "Respiratory rate increased ": 5.505813236962944, "Scab ": 5.425677990819779, "Secondary adrenocortical insufficiency ": 13.431084300848052, "Sensitive skin ": 4.745629469118601, "Skin atrophy ": 27.395409780727213, "Skin burning sensation ": 18.185668122103763, "Skin exfoliation ": 14.6373037950837, "Skin fissures ": 6.2804794138788855, "Skin haemorrhage ": 3.405066625463615, "Skin hyperpigmentation ": 14.925828477450448, "Skin infection ": 16.482734146931246, "Skin irritation ": 10.504449747979775, "Skin lesion ": 4.589618615293853, "Skin swelling ": 11.491438452590453, "Skin weeping ": 305.24579596888844, "Skin wrinkling ": 54.00945368920078, "Sleep disorder due to a general medical condition ": 4.125760092701747, "Staphylococcal infection ": 2.064096075479869, "Steroid withdrawal syndrome ": 475.4832521146338, "Tachypnoea ": 2.38730204436444, "Temperature regulation disorder ": 12.169902675443296, "Tendonitis ": 4.708546931594012, "Therapeutic product effect incomplete ": 2.049848658028277, "Thyrotoxic crisis ": 21.834880983549144, "Topical steroid withdrawal reaction ": 237.4904148028552, "Toxic epidermal necrolysis ": 3.8657258517792914, "Urinary tract disorder ": 26.60324510581443, "Wheezing ": 3.379292472098378} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/539.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/539.json new file mode 100644 index 00000000000..f848194a991 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/539.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 20.92162756123594, "Hypercalcaemia ": 408.7547512422973, "Hypervitaminosis ": 12004.371426589903, "Intentional product misuse ": 32.936759697651475, "Off label use ": 5.461430253220837} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/54.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/54.json new file mode 100644 index 00000000000..b2257d01b48 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/54.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.357130840705633, "Alanine aminotransferase increased ": 2.0029074851168747, "Amnesia ": 2.722934579715965, "Aspartate aminotransferase increased ": 2.28943919081107, "Coma ": 2.2575438490669297, "Completed suicide ": 4.259953852420468, "Depression ": 2.4672795991243306, "Diabetes mellitus ": 2.733659929445376, "Drug hypersensitivity ": 3.0030386377431832, "Drug interaction ": 4.139369269879214, "Exposure during pregnancy ": 2.3168431560993987, "Hyperglycaemia ": 2.932935963249306, "Hypersensitivity ": 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"Splenomegaly ": 48.70300139290743, "Thrombocytopenia ": 2.2886327749829336, "Weight increased ": 3.028125320974097} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/541.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/541.json new file mode 100644 index 00000000000..e3c4f6c31b3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/541.json @@ -0,0 +1 @@ +{"Abdominal distension ": 5.002028226268736, "Bronchitis ": 5.372261402599774, "Cellulitis ": 3.293885050386294, "Death ": 3.1450687884129183, "Device infusion issue ": 134.81785238934387, "Erythema ": 2.997586707780755, "Illness ": 3.7442010750574433, "Inappropriate schedule of product administration ": 3.5836123627091583, "Incorrect dose administered ": 4.456709770838998, "Infection ": 3.4340667064465413, "Infusion related reaction ": 3.3763105294911497, "Infusion site discharge ": 409.8161138455493, "Infusion 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/542.json @@ -0,0 +1 @@ +{"Fall ": 4.033610703738835} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/543.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/543.json new file mode 100644 index 00000000000..0b528d75b05 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/543.json @@ -0,0 +1 @@ +{"Abdominal pain upper ": 19.7594841416916, "Adverse event ": 96.01779975622595, "Apparent death ": 3002.8779500427586, "Gastric haemorrhage ": 389.9155962150428, "Gastric perforation ": 2341.8356390871418, "Gastritis erosive ": 778.2955641308783, "Gastrointestinal disorder ": 45.21604268733434, "General physical health deterioration ": 41.74013679922363, "Stress ": 119.16129990853575} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/544.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/544.json new file mode 100644 index 00000000000..3c7cf51a7a5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/544.json @@ -0,0 +1 @@ +{"Accident ": 2.571229126322253, "Alopecia ": 6.034025622932893, "Anaemia ": 2.866856742570888, "Anaemia macrocytic ": 3.4056776782367724, "Aphonia ": 2.112672352822748, "Aphthous ulcer ": 2.166572291530525, "Appetite disorder ": 3.0988391054693385, "Arthropod bite ": 4.026229544770969, "Back disorder ": 2.053451511423694, "Basophil count increased ": 9.281015349640894, "Basophil percentage increased ": 17.46430699825248, "Blood calcium decreased ": 3.067188052037176, "Blood calcium increased ": 2.0534482496794126, "Blood disorder ": 3.10317920404061, "Blood iron decreased ": 3.563610610790532, "Blood potassium decreased ": 2.882939020667273, "Blood test abnormal ": 9.42028648752632, "Body height decreased ": 5.219871967464576, "Body surface 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": 15.039361850301924, "Nerve injury ": 2.6269853037258817, "Neuropathy peripheral ": 3.80939649713573, "Neutropenia ": 22.491671207551526, "Neutrophil count abnormal ": 3.518592586697804, "Neutrophil count decreased ": 16.268960169871683, "Oesophageal pain ": 2.1298317227998886, "Oesophageal stenosis ": 2.4235391458587423, "Oestrogen receptor assay positive ": 13.605110566070923, "Onychoclasis ": 15.583683980199767, "Oophorectomy ": 16.828134281834593, "Oral disorder ": 2.2929451276594057, "Oral infection ": 5.228113791390726, "Oral mucosal blistering ": 2.5852205198454783, "Oral pain ": 4.754720436185472, "Oral surgery ": 10.91489074330277, "Osteomyelitis ": 2.646834346981601, "Osteonecrosis of jaw ": 8.663465993503198, "Ovarian disorder ": 7.080428342156689, "Paranasal sinus hypersecretion ": 5.720525304362393, "Pathological fracture ": 3.957199147952972, "Pharyngeal disorder ": 3.822846010394968, "Platelet count decreased ": 5.355804261632757, "Platelet disorder ": 3.723636835827567, "Pleural effusion ": 3.164173986143324, "Pneumonia ": 2.4666671724433, "Pneumonitis ": 2.468327104113717, "Poor quality product administered ": 3.111446403852923, "Pre-existing condition improved ": 2.1848773686945995, "Product administration interrupted ": 4.6872605400474265, "Product dispensing error ": 4.095536287614363, "Product dispensing issue ": 5.772013421315129, "Product dose omission in error ": 14.816397952362763, "Product dose omission issue ": 4.560029414065735, "Product packaging difficult to open ": 16.42254706027971, "Product prescribing error ": 2.093625124404104, "Product prescribing issue ": 2.314142591208772, "Product size issue ": 3.3666547380900558, "Product use complaint ": 2.382685744245473, "Product use issue ": 2.2085648386272427, "Pulmonary mass ": 2.1814186579031767, "Pulmonary oedema ": 3.798827063230996, "Pulmonary thrombosis ": 8.379666530052425, "Radiation injury ": 19.616821712125684, "Red blood cell count abnormal ": 14.157582683321062, "Red blood cell count decreased ": 16.87773232875127, "Red cell distribution width increased ": 7.306818359373613, "Scratch ": 2.134318822522298, "Second primary malignancy ": 30.318219119167768, "Sensitivity to weather change ": 2.2702795348853173, "Shoulder fracture ": 2.381525583225077, "Sinus disorder ": 2.835737815491773, "Spinal disorder ": 2.894286859712343, "Spinal fracture ": 3.102523817966909, "Spinal operation ": 3.0322231324572217, "Spinal pain ": 2.1381730449540424, "Stomatitis ": 7.54643731533004, "Stress ": 2.671666498681022, "Taste disorder ": 2.473688549528689, "Terminal state ": 2.163928710991041, "Thrombocytopenia ": 2.605992565160629, "Thrombosis ": 2.916409384188319, "Tongue blistering ": 2.3188982405938505, "Tongue disorder ": 2.721941127507206, "Tooth abscess ": 2.5033381256856058, "Tooth disorder ": 4.42049864003743, "Tooth extraction ": 6.649810531628682, "Tooth fracture ": 2.051550178106564, "Tooth infection ": 3.639243743902664, "Toothache ": 2.162672460436755, "Trichorrhexis ": 8.27499638243069, "Trigger finger ": 2.800801972186056, "Tumour haemorrhage ": 2.2090879581435483, "Tumour marker abnormal ": 30.67250128328673, "Tumour marker increased ": 34.73626356611721, "Tumour pain ": 9.453540647256586, "Upper limb fracture ": 3.9486453295592447, "Upper-airway cough syndrome ": 3.036887642197566, "Urinary tract infection ": 3.3060110375070635, "Vein disorder ": 2.638955868582172, "Vein rupture ": 8.878906713193357, "Vitamin B12 decreased ": 2.8129774346695293, "Vulvovaginal dryness ": 2.727969265397052, "Weight decreased ": 2.150379073574987, "Weight fluctuation ": 4.347649802845661, "White blood cell count abnormal ": 14.034120436953607, "White blood cell count decreased ": 20.23655126051729, "White blood cell disorder ": 7.523910379794159, "Wound complication ": 2.065868311439693, "Wound infection ": 2.320430899703708} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/545.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/545.json new file mode 100644 index 00000000000..ea4d8ea6c58 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/545.json @@ -0,0 +1 @@ +{"Aspergillus infection ": 55.08954281720174, "Atrial fibrillation ": 10.00764399171014, "Blood lactate dehydrogenase increased ": 11.660909976688318, "Bronchopulmonary aspergillosis ": 20.694792117955508, "Cerebral aspergillosis ": 287.7403297789392, "Chronic lymphocytic leukaemia ": 316.67272627766965, "Chronic lymphocytic leukaemia recurrent ": 753.4167143014894, "Cytopenia ": 16.70377268500021, "Disease progression ": 16.790761862684313, "Drug interaction ": 3.371357128086994, "Drug resistance ": 8.485543119963147, "Febrile neutropenia ": 6.777115586950506, "Haemorrhage ": 4.512287200584412, "Infection ": 5.288100759325498, "Mantle cell lymphoma recurrent ": 455.5528273194338, "Neutropenia ": 6.134017951018556, "Neutrophil count decreased ": 3.01895934381053, "Off label use ": 3.158360871949148, "Pancytopenia ": 3.5397316369364558, "Platelet count decreased ": 3.817278220246769, "Progressive multifocal leukoencephalopathy ": 38.77745130906629, "Rash maculo-papular ": 3.65299281642972, "Splenomegaly ": 14.468967682550687, "Therapeutic product effect incomplete ": 5.515691145785869, "Therapy partial responder ": 25.24757006552831, "Thrombocytopenia ": 3.5338274272083177, "Treatment failure ": 2.6763459800547627, "Tumour lysis syndrome ": 31.630603538295382} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/546.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/546.json new file mode 100644 index 00000000000..91a88535538 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/546.json @@ -0,0 +1 @@ +{"Abdominal tenderness ": 3.421873907536314, "Accidental exposure to product by child ": 2.044057906214277, "Accidental overdose ": 3.704540287481164, "Accidental poisoning ": 14.791116197444202, "Acidosis ": 7.098283005252054, "Acute generalised exanthematous pustulosis ": 5.515148025482381, "Acute hepatic failure ": 5.215297166348974, "Acute kidney injury ": 4.4055953412739015, "Acute respiratory distress syndrome ": 2.3897424803225733, "Agranulocytosis ": 3.023433015496555, "Akinesia ": 3.973665210715577, "Alcohol poisoning ": 3.741636567455613, "Allergy to animal ": 9.204938023619995, "Anaphylactic reaction ": 2.0974637126821314, "Angioedema ": 3.508300677439365, "Angular cheilitis ": 8.013172984045115, "Anuria ": 7.300396179883529, "Apnoea ": 3.643004603410384, "Apraxia ": 5.189039386941863, "Areflexia ": 3.518931992257468, "Aspiration ": 4.556899581465086, "Atelectasis ": 5.642420036713486, "Atrial septal defect ": 3.871928387731611, "Bile acids increased ": 61.6138247137884, "Blood bicarbonate decreased ": 6.4731692348201335, "Blood lactic acid increased ": 2.179345727958625, "Blood pH decreased ": 8.48137088452831, "Blood pH increased ": 53.68429781821969, "Blood urea increased ": 3.1792103723705267, "Brain death ": 5.082746119840254, "Brain injury ": 3.340828773615842, "Brain oedema ": 3.64743729290516, "Bronchial hyperreactivity ": 5.416079253761132, "Bronchial wall thickening ": 6.947162610014593, "Bronchitis chronic ": 3.597295329366199, "Cardiac arrest ": 2.560417477220527, "Cardio-respiratory arrest ": 6.760083834301645, "Cardiomegaly ": 2.164930251145773, "Central nervous system lesion ": 2.3206654160323907, "Cleft lip ": 10.142332201267935, "Cleft lip and palate ": 10.523635804757848, "Cleft palate ": 6.91740063532181, "Clonus ": 8.157182332833603, "Clostridium difficile infection ": 2.947251327698933, "Coagulopathy ": 2.2098481279247677, "Colitis ischaemic ": 2.4523218880520417, "Colitis microscopic ": 2.421737694377692, "Coma ": 3.6888094389882102, "Coma scale abnormal ": 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"Hypoalbuminaemia ": 3.128634439856203, "Hypochromic anaemia ": 7.843914610653111, "Hypopnoea ": 3.704401208047511, "Hypotension ": 2.1558033066021616, "Ileal perforation ": 16.457301471061623, "Inadequate analgesia ": 6.001305690065143, "Incorrect drug administration rate ": 18.919630755593754, "Incorrect product administration duration ": 2.20232104615282, "Infusion site discharge ": 17.220507142965946, "Infusion site discomfort ": 86.92604237483933, "Infusion site erythema ": 11.357535975605902, "Infusion site induration ": 68.49313046470938, "Infusion site irritation ": 29.044063949630686, "Infusion site pain ": 8.819957091522008, "Infusion site pruritus ": 8.312179719830008, "Infusion site swelling ": 15.730499965745548, "Intentional overdose ": 15.475397069824515, "Intentional product misuse ": 3.105478247839591, "Intervertebral disc disorder ": 4.621827501322883, "Intervertebral disc protrusion ": 2.270474365814132, "Ischaemia ": 2.380382687382895, "Kidney malformation ": 25.27663583011697, "Kounis syndrome ": 11.877066658304782, "Lactic acidosis ": 2.586924139039233, "Latent tuberculosis ": 13.153736572005554, "Leukocytosis ": 2.556335006828665, "Lip oedema ": 3.4243751666264832, "Liver injury ": 3.16786042811094, "Lower gastrointestinal haemorrhage ": 2.560607459385219, "Lung infiltration ": 2.066134980560748, "Major depression ": 2.253603958169095, "Maternal exposure timing unspecified ": 3.572631583992928, "Mean cell haemoglobin concentration decreased ": 10.572978677337328, "Medication error ": 4.136007331880804, "Medication overuse headache ": 38.72505589940975, "Mental status changes ": 2.602545099966308, "Metabolic acidosis ": 8.926399798142526, "Methaemoglobinaemia ": 7.733565513227944, "Microcephaly ": 10.311142660845665, "Micturition frequency decreased ": 47.07804721196963, "Miosis ": 2.683210750961254, "Mitochondrial toxicity ": 6.304984210756544, "Mucosal disorder ": 5.740734703305691, "Multiple organ dysfunction syndrome ": 2.3871455800737422, "Muscle spasticity ": 3.662268482713934, "Mydriasis ": 2.57348349358205, "Nasal dryness ": 5.95751326992526, "Nasal polyps ": 3.657189395413015, "Nerve compression ": 7.590653751468527, "Nikolsky's sign ": 7.656267664893967, "Normal newborn ": 2.9946487638060435, "Nystagmus ": 2.1040351789282403, "Obstructive airways disorder ": 2.25409525695472, "Oesophagitis ": 2.7239424092858573, "Oligoarthritis ": 45.39573188822148, "Oliguria ": 3.4213792468862194, "Oral mucosa erosion ": 3.9831365514475183, "Overdose ": 6.146872504657533, "Patent ductus arteriosus ": 7.5524229690021, "Peptic ulcer ": 4.539264714386686, "Periorbital oedema ": 3.1914461391077844, "Poisoning ": 4.962939752374636, "Poisoning deliberate ": 3.323374485896906, "Polyarthritis ": 2.2911146316362787, "Post-traumatic stress disorder ": 2.620573818334706, "Potentiating drug interaction ": 2.1043027363369298, "Product administration interrupted ": 15.276899283236482, "Pseudomonal sepsis ": 6.352531771174996, "Pseudomonas infection ": 3.1410134279904565, "Pulseless electrical activity ": 5.7802075477885255, "Purulent discharge ": 10.35079442418304, "Renal tubular acidosis ": 9.599299729202498, "Renal tubular necrosis ": 4.597349646826273, "Respiratory acidosis ": 4.94548005105974, "Respiratory arrest ": 4.829623987025287, "Respiratory rate decreased ": 3.9286644171193807, "Respiratory symptom ": 4.275672549454443, "Retching ": 3.0653927796386777, "Retinopathy ": 2.356505856554259, "Right atrial dilatation ": 68.35155925657848, "Right ventricular dilatation ": 33.850797699135974, "Right ventricular failure ": 2.7356591029030284, "Sacral pain ": 9.559130714319048, "Self-medication ": 9.622286655536966, "Serotonin syndrome ": 3.994458242259347, "Shock ": 4.626736044374078, "Shock haemorrhagic ": 2.2720273099398463, "Sinus bradycardia ": 2.4331116040741114, "Sinus tachycardia ": 2.717644410841382, "Skin laceration ": 4.167067591809862, "Skin swelling ": 3.0143620528474298, "Slow response to stimuli ": 3.305553509426986, "Somnolence ": 2.5205927263707903, "Sopor ": 4.6808137112386605, "Spirometry abnormal ": 21.02187982863005, "Staphylococcal sepsis ": 2.5557077354332383, "Stevens-Johnson syndrome ": 7.2422166461939534, "Stupor ": 4.001873510360035, "Substance abuse ": 2.411940675954169, "Suicide attempt ": 12.69977664635386, "Superinfection ": 9.612616255094716, "Superior mesenteric artery syndrome ": 72.58110008207089, "Suspected suicide ": 47.059842522309374, "Synovial cyst ": 5.28546708989836, "Systolic dysfunction ": 31.149638060258376, "Therapeutic product effect increased ": 4.980268648153829, "Throat tightness ": 2.0623994910531724, "Tongue oedema ": 2.673700126692938, "Toxic epidermal necrolysis ": 8.540315390374037, "Toxicity to various agents ": 12.278529284242463, "Tracheobronchitis ": 25.983639904427555, "Transposition of the great vessels ": 15.19842883217773, "Tricuspid valve incompetence ": 3.992271148059829, "Tubulointerstitial nephritis ": 4.049356413148567, "Type IV hypersensitivity reaction ": 4.558801500318839, "Unresponsive to stimuli ": 3.501804982344113, "Upper gastrointestinal haemorrhage ": 4.404948008030238, "Upper respiratory tract infection ": 2.284212370149188, "Ventricular septal defect ": 4.285084760815094, "Weight fluctuation ": 3.5382713112032005} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/547.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/547.json new file mode 100644 index 00000000000..852f54e16d0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/547.json @@ -0,0 +1 @@ +{"Blood glucose increased ": 4.906519065630417, "Diarrhoea ": 2.459795177689464, "Glycosylated haemoglobin increased ": 35.549503557834065, "Pancreatitis acute ": 23.105299434417457} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/548.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/548.json new file mode 100644 index 00000000000..db241cda5d9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/548.json @@ -0,0 +1 @@ +{"Angioedema ": 98.69102282093216, "Drug ineffective ": 5.100627621479056, "Hereditary angioedema ": 148.55685883911383, "Off label use ": 6.079907390989413, "Therapy non-responder ": 77.49263385000029} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/549.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/549.json new file mode 100644 index 00000000000..c9ed0e8fea4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/549.json @@ -0,0 +1 @@ +{"Accelerated hypertension ": 46.27348328858969, "Acute coronary syndrome ": 7.110595663817508, "Acute lymphocytic leukaemia ": 69.15736258283168, "Acute lymphocytic leukaemia recurrent ": 126.7784429543712, "Acute myeloid leukaemia ": 2.062949410630812, "Acute myocardial infarction ": 7.349228006838453, "Allogenic stem cell transplantation ": 129.94614167075676, "Amylase increased ": 12.601941774524814, "Angina pectoris ": 2.5644106512476155, "Angina unstable ": 7.074902856258915, "Angiopathy ": 9.050060055837887, "Arterial occlusive disease ": 6.678339062934668, "Arteriosclerosis ": 6.599810202144397, "Arteriosclerosis coronary artery ": 4.056785561356703, "Atrial fibrillation ": 5.980738636145268, "Benign prostatic hyperplasia ": 4.691031022613292, "Blast cell crisis ": 292.1844386071012, "Blast crisis in myelogenous leukaemia ": 230.3105141951547, "Blindness unilateral ": 5.637633234211379, "Bone marrow failure ": 9.445390356738072, "Bone marrow transplant ": 40.83326897485544, "Bone pain ": 2.137808468907818, "Cardiac disorder ": 2.729452683090871, "Cardiac failure ": 5.098870178541138, "Cardiac failure acute ": 5.71769684477199, "Cardiomyopathy ": 3.5179272264288315, "Cardiotoxicity ": 4.4571784064512965, "Cardiovascular disorder ": 2.010681025695614, "Carotid arteriosclerosis ": 47.80376620813438, "Carotid artery stenosis ": 18.05575825649166, "Central nervous system leukaemia ": 159.99395438148198, "Cerebral artery stenosis ": 60.35980947481789, "Cerebral infarction ": 10.697099509547677, "Cerebral ischaemia ": 11.802743506450035, "Cerebrovascular accident ": 3.155666396707232, "Chemotherapy ": 14.359773184809605, "Chronic myeloid leukaemia ": 233.67049887803984, "Chronic myeloid leukaemia recurrent ": 367.26038042018, "Chronic myeloid leukaemia transformation ": 388.9019820992351, "Constipation ": 2.2392532053641574, "Coronary artery disease ": 6.018269049740005, "Coronary artery occlusion ": 4.181051839897023, "Coronary artery stenosis ": 28.538648969253117, "Cytogenetic analysis abnormal ": 19.693262216928247, "Cytopenia ": 21.968000783436064, "Death ": 3.7045437915291592, "Dermatitis exfoliative ": 16.309643829841363, "Disease complication ": 52.22913201027892, "Disease progression ": 3.887507361715729, "Drug resistance ": 2.6884976361881665, "Dry eye ": 3.6277618961705658, "Dry skin ": 8.639024360005838, "Ejection fraction decreased ": 4.9799410910838615, "Erectile dysfunction ": 5.06324363834545, "Exfoliative rash ": 8.586620657294072, "Febrile neutropenia ": 2.08746355379326, "Full blood count abnormal ": 2.176171772150969, "Full blood count decreased ": 3.9702374987291673, "Graft versus host disease ": 14.359605768883863, "Graft versus host disease in gastrointestinal tract ": 12.296544679845432, "Graft versus host disease in skin ": 27.43963679183444, "Haematocrit decreased ": 2.0211491628069385, "Haematotoxicity ": 12.952161655373692, "Hepatic failure ": 2.4449472374071406, "Hepatomegaly ": 2.1754795957608533, "Hepatotoxicity ": 8.42043415909153, "Hyperlipidaemia ": 2.1600304147834417, "Hypertension ": 4.439337080160114, "Hypertensive crisis ": 2.9854202902178293, "Hypertransaminasaemia ": 2.419927285511357, "Hypertriglyceridaemia ": 5.53918065904896, "Ichthyosis ": 224.17622711282465, "Ichthyosis acquired ": 216.95484361890703, "Infection ": 2.499938531406007, "Intermittent claudication ": 18.31691825185636, "Ischaemic stroke ": 9.488444658453872, "Leukaemia recurrent ": 31.68209624846668, "Leukocytosis ": 5.77165108887904, "Lipase increased ": 22.64525056272141, "Liver disorder ": 2.3031826408148737, "Liver function test increased ": 2.1667793031086, "Lymphocyte count decreased ": 2.385453769951053, "Mitral valve incompetence ": 4.1329524260223565, "Moyamoya disease ": 138.05836805067898, "Multiple organ dysfunction syndrome ": 2.38448957811382, "Myocardial infarction ": 3.066776604543855, "Myocardial ischaemia ": 6.990298694124772, "Neoplasm progression ": 20.95868142075205, "Neutropenia ": 2.2872187422178123, "No adverse event ": 2.43393812076235, "Off label use ": 3.880959680170221, "Pancreatic enzymes increased ": 13.177115422234298, "Pancreatitis ": 11.03762090090398, "Pancreatitis acute ": 5.193429312729352, "Pancytopenia ": 5.2916260186285, "Pericardial effusion ": 7.548719133276303, "Peripheral arterial occlusive disease ": 69.0623561839334, "Peripheral artery occlusion ": 12.879366070197138, "Peripheral artery stenosis ": 62.84336830361444, "Peripheral artery thrombosis ": 11.320424895315822, "Peripheral ischaemia ": 6.444370132216057, "Peripheral vascular disorder ": 4.207833105397713, "Philadelphia chromosome positive ": 93.7088246239684, "Philadelphia positive acute lymphocytic leukaemia ": 2288.780376911525, "Pityriasis rubra pilaris ": 53.93698520196627, "Platelet count abnormal ": 9.54351824708954, "Platelet count decreased ": 3.3027509225960663, "Pleural effusion ": 5.522035925912177, "Pneumonia ": 2.5469017214902885, "Pneumonia fungal ": 11.280808610512429, "Posterior reversible encephalopathy syndrome ": 5.8027476188123925, "Prinzmetal angina ": 34.87955655555459, "Product administered to patient of inappropriate age ": 15.700536603397218, "Pulmonary arterial hypertension ": 2.6699524652904234, "Pulmonary hypertension ": 4.181125461880895, "Red blood cell count decreased ": 2.3439505318834817, "Renal artery stenosis ": 64.84892343925344, "Retinal artery occlusion ": 7.683465024856064, "SARS-CoV-2 test positive ": 2.3584602267752177, "Scleroderma ": 9.602887915914474, "Sepsis ": 3.915848959366692, "Septic shock ": 6.230567785036587, "Skin exfoliation ": 6.776978661121519, "Skin lesion ": 2.024141604145083, "Skin toxicity ": 5.531173261438314, "Splenomegaly ": 2.951571122237291, "Stem cell transplant ": 80.01820927072826, "Sudden death ": 3.120851558584854, "Supraventricular tachycardia ": 2.224836690995568, "Therapeutic response decreased ": 2.0393038060943285, "Therapy non-responder ": 6.667315586010314, "Therapy partial responder ": 5.7934551053142505, "Thrombocytopenia ": 5.37349346706525, "Thrombotic microangiopathy ": 2.9541735766336026, "Transaminases increased ": 3.228045883148847, "Transient ischaemic attack ": 3.4443135580174005, "Transplant ": 65.54273089259819, "Treatment noncompliance ": 4.464177811067646, "Tumour marker increased ": 6.6734482241142175, "Unevaluable event ": 3.4328042221818205, "Vascular occlusion ": 12.789059565982903, "Venoocclusive liver disease ": 6.92449043178623, "Ventricular hypokinesia ": 6.815515388489292, "White blood cell count increased ": 2.877764765817604} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/55.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/55.json new file mode 100644 index 00000000000..fec110e1891 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/55.json @@ -0,0 +1 @@ +{"Hypersensitivity ": 11.663667858783253, "Limb injury ": 154.76060111989247, "Throat irritation ": 69.15917243321545} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/550.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/550.json new file mode 100644 index 00000000000..b25d5a9d93d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/550.json @@ -0,0 +1 @@ +{"Hyperglycaemic hyperosmolar nonketotic syndrome ": 2439.3512547825017} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/551.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/551.json new file mode 100644 index 00000000000..3102e93d167 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/551.json @@ -0,0 +1 @@ +{"Alopecia ": 2.5560528388722874, "Arthritis ": 12.91222712264465, "Condition aggravated ": 3.106084975112421, "Crohn's disease ": 13.828168476310458, "Drug ineffective ": 5.131002570774772, "Injection site erythema ": 2.5795402305388357, "Injection site pain ": 7.634727393614623, "Injection site reaction ": 4.517619077376616, "Joint swelling ": 2.460918729537112, "Loss of therapeutic response ": 167.01291200352358, "Peripheral swelling ": 2.094863910594089, "Product substitution issue ": 11.137470791797783, "Psoriasis ": 25.684053552221773, "Skin exfoliation ": 11.894034104656086, "Skin reaction ": 13.726564452481314} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/552.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/552.json new file mode 100644 index 00000000000..071fd597482 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/552.json @@ -0,0 +1 @@ +{"Disease progression ": 16.252868153578163} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/553.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/553.json new file mode 100644 index 00000000000..fbcbe587913 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/553.json @@ -0,0 +1 @@ +{"Chondrolysis ": 44027.57818524235, "Musculoskeletal pain ": 661.1240093632636} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/554.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/554.json new file mode 100644 index 00000000000..e784888ce40 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/554.json @@ -0,0 +1 @@ +{"Condition aggravated ": 2.027760630417852, "Drug intolerance ": 3.585108058030616, "Dry eye ": 34.10584149134583, "Eye irritation ": 324.3741309271525, "Eye pain ": 72.48049292124732, "Eye pruritus ": 51.54901934553404, "Eye swelling ": 16.442496623357297, "Intentional product misuse ": 6.831764581064476, "Lacrimation increased ": 111.14353348151823, "Multiple use of single-use product ": 267.97990693400607, "Ocular discomfort ": 33.26831969137706, "Ocular hyperaemia ": 83.92988741684864, "Off label use ": 7.598423023086233, "Prescribed overdose ": 42.16403842664547, "Product availability issue ": 39.08392780175632, "Product use in unapproved indication ": 3.1376151924406703, "Recalled product administered ": 223.1545420209044, "Swelling of eyelid ": 40.99568776187496, "Therapy interrupted ": 52.68667732857445, "Vision blurred ": 6.614781387406226, "Visual impairment ": 5.959429557153886} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/555.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/555.json new file mode 100644 index 00000000000..d72d9d741b5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/555.json @@ -0,0 +1 @@ +{"Anxiety ": 4.527741045471823, "Arthritis ": 3.642187158944324, "Arthritis infective ": 363.0507514653518, "Blood pressure 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"Weight increased ": 7.849426230188255, "Wound ": 27.975798807876608, "Wound infection ": 220.4631259569844} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/556.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/556.json new file mode 100644 index 00000000000..99267426e1c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/556.json @@ -0,0 +1 @@ +{"Toxicity to various agents ": 119.73032131122972} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/557.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/557.json new file mode 100644 index 00000000000..b586aa2be8b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/557.json @@ -0,0 +1 @@ +{"Condition aggravated ": 5.788753732604919, "Death ": 2.082546645846126, "Dyspnoea ": 2.672147067415031, 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/561.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/561.json new file mode 100644 index 00000000000..403a495d09a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/561.json @@ -0,0 +1 @@ +{"Application site erythema ": 46.70213617853167, "Application site scab ": 497.746941445022, "Blister ": 5.029351794573634, "Burning sensation ": 4.472287690951847, "Erythema ": 6.580728444169679, "Erythema multiforme ": 25.1010419806324, "Haemorrhage ": 2.700703525230742, "Inflammation ": 13.30360113259045, "Influenza like illness ": 2.977177588933304, "Oedema ": 8.075763175232542, "Off label use ": 4.94419887528734, "Scab ": 109.0103218570603, "Skin abrasion ": 54.20172693234086, "Skin erosion ": 174.81077875704233, "Skin exfoliation ": 9.383746553014925, "Skin lesion ": 11.612426866497596, "Skin reaction ": 15.8383975256756, "Skin ulcer ": 13.926701525783388, "Skin weeping ": 219.5377969668076, "Ulcer ": 44.77487349557784} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/562.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/562.json new file mode 100644 index 00000000000..7a284276502 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/562.json @@ -0,0 +1 @@ +{"Anaemia ": 2.505392995944377, "Cardiac failure ": 4.583356843038923, "Disease progression ": 5.613114123184182, "Febrile neutropenia ": 5.969290767559164, "General physical health deterioration ": 2.60347905363697, "Infection ": 3.7309862787241928, "Interstitial lung disease ": 4.273957163611622, "Neutropenia ": 14.763061175402052, "Pancytopenia ": 10.900286304644728, "Plasma cell myeloma ": 88.85475027703849, "Pneumonia ": 3.680344077622951, "Rash maculo-papular ": 4.417619662793072, "Sepsis ": 4.741339880811824, "Thrombocytopenia ": 10.067001500856446} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/563.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/563.json new file mode 100644 index 00000000000..d5f7f8e0f41 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/563.json @@ -0,0 +1 @@ +{"Cough ": 9.19720917889573, "Death ": 2.4906504656237733, "Device issue ": 63.90759022640978, "Dyskinesia ": 22.129918832832896} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/564.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/564.json new file mode 100644 index 00000000000..85c1e39b79f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/564.json @@ -0,0 +1 @@ +{"Abscess ": 2.1076322238246754, "Acute generalised exanthematous pustulosis ": 2.700346096947215, "Acute respiratory distress syndrome ": 2.0402518939352268, "Anaemia ": 32.273498398476804, "Anal abscess ": 11.879287286122594, "Anal fissure ": 11.846661823899442, "Anal haemorrhage ": 13.15985497548179, "Anal pruritus ": 156.10212426211726, "Anorectal discomfort ": 47.329415359232186, "Anorectal disorder ": 69.15428657856077, "Aphthous ulcer ": 3.3777359831663016, "Aplastic anaemia ": 4.699734438463656, "Ascites ": 6.281502988457305, "Asthenia ": 2.513329247470314, "Bacteraemia ": 2.582092121152389, "Blood bilirubin increased ": 2.1171747402475107, "Blood creatinine abnormal ": 5.753007920460614, "Blood creatinine increased ": 3.3260236428981806, "Blood thyroid stimulating hormone increased ": 5.017106699976378, "Blood uric acid increased ": 10.641717064275609, "Bone marrow failure ": 6.5768804494509565, "Cholecystitis acute ": 6.322766785277191, "Cutaneous vasculitis ": 2.1099434692166, "Decreased appetite ": 2.799763450089041, "Depression ": 3.332999509911333, "Dermatitis ": 4.769012724621072, "Dermatitis bullous ": 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17.434684076443634, "Haemorrhoids ": 20.332976185088366, "Hepatic cirrhosis ": 8.140975922628007, "Hepatic encephalopathy ": 3.016371032849432, "Hepatic failure ": 3.059422955011196, "Hepatitis C ": 2.138588627408528, "Hepatocellular carcinoma ": 2.581830366445286, "Hyperbilirubinaemia ": 2.2880024339723497, "Hyperthermia ": 3.2305144162995467, "Hypertriglyceridaemia ": 3.9926395481990777, "Hyperuricaemia ": 14.17020391769327, "Leukopenia ": 6.723911925873681, "Liver transplant ": 19.206452201029723, "Lymphadenopathy mediastinal ": 14.850550416853643, "Lymphopenia ": 2.871220037072409, "Mental disorder ": 2.429141203861877, "Mood swings ": 3.250206722718535, "Multiple organ dysfunction syndrome ": 3.2953642402732037, "Neutropenia ": 4.546049100833519, "Oedema ": 2.2834940836454782, "Oedema peripheral ": 2.2919966713737905, "Oral candidiasis ": 3.4666639284750143, "Oral disorder ": 2.899656222909162, "Oral pain ": 2.1455777641952323, "Otitis media ": 4.32768758828345, "Pancreatitis 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7.16727555236977, "Product use in unapproved indication ": 4.194030525106931, "Productive cough ": 8.02698776465279, "Pulmonary congestion ": 10.464569005109356, "Rehabilitation therapy ": 48.49524189841461, "Respiratory tract congestion ": 12.982931428156302, "Respiratory tract infection ": 9.707100258518134, "Rhinorrhoea ": 2.681956772739372, "Rib fracture ": 6.063877870495214, "Secretion discharge ": 5.714809058740615, "Sleep apnoea syndrome ": 4.356379543840764, "Sleep disorder due to a general medical condition ": 18.40221145482263, "Spinal fracture ": 3.305484729785217, "Sputum discoloured ": 13.311410504466622, "Sputum increased ": 18.44765925060612, "Staphylococcal infection ": 2.921068007709645, "Stent placement ": 6.058443078894984, "Surgery ": 4.124536575893146, "Therapeutic product effect incomplete ": 6.216511012375739, "Throat irritation ": 4.328323319820536, "Underdose ": 9.472191046330677, "Urinary retention ": 8.69593521411426, "Viral infection ": 3.357708832804083, "Vision blurred ": 2.329794543574881, "Wheezing ": 10.93278925054894, "Wrong technique in device usage process ": 24.373815622404315} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/566.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/566.json new file mode 100644 index 00000000000..46945d16022 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/566.json @@ -0,0 +1 @@ +{"Alopecia ": 2.045855905600176, "Anaemia ": 2.7213039670509187, "General physical health deterioration ": 2.6485928680290987, "Hepatic function abnormal ": 5.055162197363615, "Hyperbilirubinaemia ": 15.098558188528974, "Hyperlipidaemia ": 33.96573037562357, "Hypertriglyceridaemia ": 28.139140514324016, "Immune reconstitution inflammatory syndrome ": 37.928620840209845, "Lactic acidosis ": 10.615151331617422, "Lipoatrophy ": 131.48348004087248, "Lipodystrophy acquired ": 138.6639156308147, "Nephrolithiasis ": 6.733526716356552, "Osteonecrosis ": 2.0354347674550377, "Pancreatitis ": 3.195000741685373, "Progressive multifocal leukoencephalopathy ": 79.22306257314399, "Urinary tract infection ": 2.3910834119170024} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/567.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/567.json new file mode 100644 index 00000000000..609f3d47b16 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/567.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 2.6070964307545883, "Abnormal faeces ": 4.7365412803820215, "Allergy to metals ": 68.33082693779392, "Apathy ": 6.97649788629731, "Apnoea ": 42.26384642761485, "Attention deficit hyperactivity disorder ": 11.203989528457498, "Autism spectrum disorder ": 28.138576039174293, "Bradycardia ": 2.021709735785601, "Bronchiolitis ": 14.631801249887712, "Bronchitis ": 4.793074176553232, 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": 141.45240558382972, "Vaccination site oedema ": 4.47265674319959, "Vaccination site pruritus ": 3.633828503933065, "Vaccination site reaction ": 4.933438120595101, "Vaccination site swelling ": 3.555226572751404, "Viral infection ": 4.231417485719541, "Vomiting ": 2.449866841673861, "Vomiting projectile ": 15.627793947683672} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/568.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/568.json new file mode 100644 index 00000000000..a768dbc32c8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/568.json @@ -0,0 +1 @@ +{"Alopecia ": 2.6576386657225, "Anaemia ": 5.254295068611745, "Decreased appetite ": 2.839799559386033, "Depression ": 5.808101471663663, "Influenza like illness ": 2.3352455434726824, "Insomnia ": 2.2877596567567324, "Leukopenia ": 7.973762124647253, "Neutropenia ": 4.776097260006367, "Product complaint 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"Constipation ": 3.1532467897573757, "Crohn's disease ": 17.075798827570043, "Drug hypersensitivity ": 3.279135469330865, "Drug ineffective ": 2.6136015809108284, "Frequent bowel movements ": 14.505363748733272, "Haematochezia ": 10.800432444208164, "Heart rate decreased ": 10.545648607614371, "Inappropriate schedule of product administration ": 3.60955537663064, "Influenza ": 2.471487595632349, "Intentional product use issue ": 7.615369493215052, "Joint swelling ": 2.018960404184452, "Lower respiratory tract infection ": 7.39735095172084, "Lung disorder ": 3.76549353786466, "Nasopharyngitis ": 3.1595228284850534, "Off label use ": 4.126173577173912, "Oropharyngeal pain ": 3.66686313794112, "Product use issue ": 5.035902344249279, "Rectal haemorrhage ": 6.27393944234994, "Stress ": 5.449502028288671, "Therapeutic product effect incomplete ": 3.278875107376798, "Treatment failure ": 2.252093557539527, "Weight decreased ": 3.799326732341453, "Weight increased ": 5.372777792898541} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/57.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/57.json new file mode 100644 index 00000000000..bd7595a90bd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/57.json @@ -0,0 +1 @@ +{"Weight decreased ": 4.626743628226365} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/570.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/570.json new file mode 100644 index 00000000000..f571a996831 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/570.json @@ -0,0 +1 @@ +{"Acne ": 3.6345063142172536, "Adverse event ": 2.9043522442495178, "Anal incontinence ": 6.970024780586294, "Angioplasty ": 39.68660109588753, "Autoimmune colitis ": 43.81774354727842, "Blood pressure fluctuation ": 13.07389755788197, "Blood pressure systolic decreased ": 19.546202951258667, "C-reactive protein increased ": 2.863773975197051, "Candida infection ": 3.014747463427676, "Clostridium difficile infection ": 7.677456660242504, "Colitis ": 26.41931226093608, "Colitis ulcerative ": 43.56200922035162, "Condition aggravated ": 4.073503342736783, "Crohn's disease ": 21.018014706016675, "Cytomegalovirus colitis ": 71.0134433706757, "Cytomegalovirus infection ": 6.990865477225045, "Cytomegalovirus viraemia ": 11.528473410068775, "Decreased activity ": 54.36259970695628, "Diarrhoea haemorrhagic ": 4.994576768371735, "Disease recurrence ": 2.0283104752341763, "Disseminated tuberculosis ": 55.729912374370784, "Diverticulitis ": 3.4099816299741588, "Drug hypersensitivity ": 4.842428104319109, "Drug ineffective ": 3.081530684620024, "Drug ineffective for unapproved indication ": 7.123284978221578, "Drug intolerance ": 2.402137436519203, "Drug level above therapeutic ": 17.692189066382436, "Drug level decreased ": 24.54791871576932, "Drug specific antibody present ": 50.01696414162971, "Duodenitis ": 19.40263865414012, "Faecal calprotectin increased ": 44.399033910541874, "Faeces soft ": 30.192664472519443, "Flushing ": 2.207674021690632, "Frequent bowel movements ": 35.87700965493708, "Haematochezia ": 6.751309300719136, "Haemophagocytic lymphohistiocytosis ": 7.166093809176325, "Heart rate decreased ": 2.120600863498509, "Heart rate irregular ": 2.335261497722776, "Hepatosplenic T-cell lymphoma ": 320.4286824637925, "Immune reconstitution inflammatory syndrome ": 8.846545418432335, "Immune-mediated enterocolitis ": 15.64998902019602, "Inappropriate schedule of product administration ": 2.141386733512766, "Incorrect product administration duration ": 4.645671658960571, "Infrequent bowel movements ": 47.003772984888606, "Infusion related reaction ": 2.560179316215295, "Intentional product use issue ": 3.194968426746589, "Interstitial lung disease ": 2.5614844002876835, "Intestinal obstruction ": 6.1868306263258, "Latent tuberculosis ": 38.66918822824572, "Loss of libido ": 9.51673247549562, "Lower respiratory tract infection ": 2.406097792199618, "Metastases to liver ": 3.302205441203484, "Metastases to lung ": 3.9776823642643135, "Mouth ulceration ": 4.513483320089829, "Off label use ": 3.729482984703779, "Pancreatitis ": 2.671741040550064, "Pneumocystis jirovecii pneumonia ": 4.5489797844148745, "Pneumonitis ": 4.943794564730101, "Poor venous access ": 31.750527756816943, "Premature baby ": 2.1480779669871533, "Premature delivery ": 3.81408163964804, "Product use in unapproved indication ": 2.17179998331792, "Product use issue ": 5.283887379814758, "Psoriasis ": 4.077207811533406, "Pulmonary tuberculosis ": 18.702202370765622, "Rectal haemorrhage ": 17.368947854851182, "Tachyphrenia ": 35.54190639486685, "Takayasu's arteritis ": 135.00071655905907, "Therapeutic product effect incomplete ": 2.1393000337192074, "Therapeutic response decreased ": 4.048022666873796, "Therapy non-responder ": 3.5649675891777286, "Treatment failure ": 6.058111303742765, "Tuberculosis ": 9.124205567711488, "Weight increased ": 2.8641792532595662} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/571.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/571.json new file mode 100644 index 00000000000..4dbf2808490 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/571.json @@ -0,0 +1 @@ +{"Abdominal wall haematoma ": 81.90071154690648, "Application site pain ": 5.42111609672694, "Contusion ": 2.633901748787585, "Deep vein thrombosis ": 5.571379507893011, "Device issue ": 27.629176552394394, "Epistaxis ": 3.237120882360976, "Erythema ": 6.148474662075424, "Haematoma ": 23.664258543389558, "Haemorrhage ": 3.5419532050873657, "Heparin-induced thrombocytopenia ": 33.89343939392273, "Hypersensitivity ": 2.4097060858785486, "Injection site bruising ": 30.02566080062492, "Injection site erythema ": 2.801516410221856, "Injection site haematoma ": 21.13499359018867, "Injection site haemorrhage ": 25.271097339249344, "Injection site pain ": 7.797921113324845, "Injection site pruritus ": 9.18505094045733, "Intra-abdominal haematoma ": 194.17758788228116, "Maternal exposure during pregnancy ": 5.327997557508038, "Needle issue ": 146.14435753282967, "Product substitution issue ": 45.58339541123116, "Pruritus ": 4.341809521057824, "Pulmonary embolism ": 5.448588220112636, "Rash ": 2.6103788313799337, "Rash pruritic ": 4.994023248744321, "Thrombocytopenia ": 4.404736777517586, "Urticaria ": 5.099943814448609} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/572.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/572.json new file mode 100644 index 00000000000..28ec214c4ec --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/572.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 2.188402574626931, "Adrenal insufficiency ": 4.534322146058072, "Aphonia ": 12.147411688353444, "Autoimmune colitis ": 14.635524403602489, "Autoimmune hepatitis ": 2.383035737460913, "Blood calcium increased ": 3.3685091442003534, "Blood magnesium decreased ": 2.6643968558096285, "Blood potassium decreased ": 2.0215899822768413, "Blood potassium increased ": 2.862009334960658, "Blood pressure abnormal ": 4.108001222802455, "Blood pressure diastolic increased ": 4.925452566458702, "Blood pressure fluctuation ": 2.1288792481236265, "Blood pressure increased ": 5.947618298117494, "Blood sodium decreased ": 2.060608542929566, "Blood thyroid stimulating hormone increased ": 8.392077989410666, "Body surface area decreased ": 124.65937704731576, "Brain oedema ": 3.067305344091216, "Cancer pain ": 10.024317565636322, "Cardiac dysfunction ": 5.371599943587871, "Cardiac failure ": 2.5832122959487305, "Cerebral infarction ": 2.7667693661497403, "Cholecystitis ": 2.0777545468485665, "Colitis ": 2.0752499209956072, "Constipation ": 2.5310237631883075, "Death ": 4.491724882374365, "Decreased appetite ": 4.185735504711374, "Decreased immune responsiveness ": 2.0287432523324465, "Dehydration ": 4.082085413099716, "Diarrhoea ": 3.79978235941138, "Disease progression ": 13.20255485817898, "Dry skin ": 4.9808813461295225, "Dysphonia ": 16.57617538578399, "Eating disorder ": 3.904834383043246, "Enterocolitis ": 2.7525149917432192, "Faeces soft ": 2.982929618361298, "Feeding disorder ": 4.713536244005971, "Gait inability ": 2.51551395858585, "Gallbladder disorder ": 2.248766413252454, "Gastrointestinal perforation ": 8.656871112969979, "Gingival pain ": 2.2301662877538724, "Glossitis ": 4.033188573388499, "Haemoptysis ": 2.5164452478470167, "Haemorrhage urinary tract ": 4.709692375194555, "Hepatic cytolysis ": 2.0731826563986324, "Hepatic enzyme abnormal ": 3.9921451382715145, "Hepatitis ": 2.2156750662270026, "Hepatotoxicity ": 5.658952619078822, "Hernia ": 2.3519276551861603, "Hypercalcaemia ": 2.340213581533172, "Hyperkeratosis ": 15.080731101288189, "Hypersomnia ": 2.319976162969021, "Hypertension ": 7.93588981525814, "Hypertensive crisis ": 4.1559687576192905, "Hyperthyroidism ": 5.269074920036991, "Hypertransaminasaemia ": 4.049740849509499, "Hypophagia ": 2.5742421675407163, "Hypothyroidism ": 12.046258491430343, "Immune-mediated enterocolitis ": 2.363354522636749, "Immune-mediated hepatic disorder ": 23.705167993430408, "Immune-mediated hypothyroidism ": 6.001825255850177, "Impaired healing ": 2.0935331175948053, "Intestinal perforation ": 5.772307478231756, "Liver function test increased ": 2.2025627045203127, "Localised infection ": 2.178475339739858, "Malignant neoplasm progression ": 2.3582650129712976, "Metastatic renal cell carcinoma ": 57.561952567542654, "Mucosal inflammation ": 3.990599265402368, "Myasthenia gravis ": 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": 2.052953699506774, "Pulmonary thrombosis ": 2.2595050961575143, "Renal cancer ": 13.607273977950364, "Renal cancer metastatic ": 32.32716797200273, "Renal cell carcinoma ": 24.345961508837025, "Renal disorder ": 2.2510065042937533, "Renal haemorrhage ": 12.302893054259268, "Renal impairment ": 2.833168672391469, "Renal mass ": 8.194431613520164, "Second primary malignancy ": 21.67308190083684, "Skin exfoliation ": 2.672777614972349, "Skin lesion ": 2.9740811126629665, "Skin toxicity ": 2.576019913306245, "Sluggishness ": 2.5229841517033065, "Stomatitis ": 8.62823276822617, "Taste disorder ": 2.7504690893114296, "Thrombosis ": 2.1400664587322344, "Thyroid disorder ": 6.51713019786418, "Thyroiditis ": 9.683328444485342, "Tongue discomfort ": 2.858204674806904, "Tongue disorder ": 4.118691375170656, "Tubulointerstitial nephritis ": 2.1842972752489462, "Tumour haemorrhage ": 4.658695431419001, "Type 1 diabetes mellitus ": 4.835605421252635, "Weight decreased ": 4.746617401481346} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/573.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/573.json new file mode 100644 index 00000000000..634b878bbff --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/573.json @@ -0,0 +1 @@ +{"Blood lactic acid increased ": 140.35975034671853, "Hypokalaemia ": 21.139591143737825, "Hypomagnesaemia ": 132.8584058253871, "Lipase increased ": 81.7024835845914, "Neutrophil count decreased ": 17.38095976171305, "Platelet count decreased ": 9.363497786150964} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/574.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/574.json new file mode 100644 index 00000000000..0ce3704e74a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/574.json @@ -0,0 +1 @@ +{"Decreased 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5.684249792751863, "Device issue ": 13.539088830764417, "Device malfunction ": 11.843774814367356, "Diabetes mellitus inadequate control ": 45.73221546366466, "Diabetic ketoacidosis ": 8.997746470177342, "Exposure during pregnancy ": 9.77326085470436, "Fall ": 2.2324037318071643, "Foetal death ": 32.1438997235954, "Foetal exposure during pregnancy ": 8.687319405670058, "Gamma-glutamyltransferase increased ": 5.082973939784116, "Glycosylated haemoglobin increased ": 5.99950847690032, "Hyperglycaemia ": 20.059590601447745, "Hypersensitivity ": 2.18481960960173, "Hypoglycaemia ": 35.31210921510065, "Hypoglycaemia neonatal ": 81.07501212520336, "Hypoglycaemic coma ": 34.002637622298, "Hypoglycaemic unconsciousness ": 40.13525184457348, "Incorrect dose administered by device ": 23.117799935883717, "Injection site pruritus ": 5.926416077490024, "Injection site rash ": 13.398190512472777, "Injection site reaction ": 3.773379391242388, "Lactic acidosis ": 5.741622961994821, "Liquid product 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"Angina pectoris ": 4.273126204683987, "Anti-GAD antibody positive ": 46.95654069239811, "Anti-insulin antibody ": 105.00069486159164, "Anti-insulin antibody increased ": 102.09304959519568, "Anti-insulin antibody positive ": 86.28165917649825, "Apgar score low ": 5.003405455998516, "Appendicitis ": 2.853004676275869, "Appendicolith ": 5.622198272191772, "Appetite disorder ": 22.9941844941446, "Areflexia ": 6.1074669174394325, "Arterial occlusive disease ": 2.362149686090582, "Bacterial infection ": 2.271366675830864, "Bladder disorder ": 2.5526580182815954, "Blindness ": 3.0215172802751127, "Blindness unilateral ": 2.505773392245206, "Blood glucose abnormal ": 21.827265417373628, "Blood glucose decreased ": 21.955601983491853, "Blood glucose fluctuation ": 39.69045422631204, "Blood glucose increased ": 17.333196207889802, "Blood immunoglobulin E increased ": 3.9168804334622975, "Blood insulin increased ": 47.96976614974731, "Blood pH decreased ": 4.48388198417262, "Blood phosphorus increased ": 4.648412507109309, "Blood pressure systolic increased ": 2.192305886796865, "Body mass index increased ": 8.290560281353107, "Brachial plexopathy ": 26.47057963704047, "Bronchitis chronic ": 12.578460965860348, "Caesarean section ": 3.208071507238475, "Cardiac disorder ": 2.1995237919962856, "Cardiac murmur ": 3.398524815325715, "Cataract ": 3.9344252892003713, "Cataract operation ": 2.0101496829205883, "Cerebral ischaemia ": 2.0049403640211523, "Cerebral reperfusion injury ": 329.25075376844046, "Cholecystectomy ": 2.0347121735245906, "Chorea ": 5.568995500261613, "Cold sweat ": 2.8806103720428613, "Coronary artery occlusion ": 2.3730297095250528, "Coronary artery stenosis ": 2.615328110325524, "Cutaneous amyloidosis ": 166.41215052670933, "Cystitis interstitial ": 35.506549893734444, "Dementia ": 2.494178632942804, "Dementia Alzheimer's type ": 2.6365960210117487, "Depressed mood ": 2.7271226463845624, "Depressive symptom ": 20.04622772029776, "Device breakage ": 3.172652224313855, "Device defective ": 5.845063826092957, "Device issue ": 6.8122418767389314, "Device operational issue ": 15.366393445326151, "Device use issue ": 6.406533331932971, "Diabetes mellitus inadequate control ": 31.442923526123764, "Diabetic coma ": 11.622247042035267, "Diabetic complication ": 21.564700287283827, "Diabetic foot ": 27.47775794054949, "Diabetic ketoacidosis ": 11.00435716352555, "Diabetic metabolic decompensation ": 51.32322129283153, "Diabetic nephropathy ": 8.100042622105011, "Diabetic neuropathy ": 11.159458266655582, "Diabetic retinopathy ": 23.70068762808112, "Disorganised speech ": 3.6206086184757336, "Drug administered in wrong device ": 77.0786016108551, "Drug hypersensitivity ": 3.079063954170403, "Drug level below therapeutic ": 4.4286373594416375, "Dyspnoea exertional ": 3.236672286225232, "Erosive duodenitis ": 12.2897902084719, "Expired product administered ": 2.055255835664574, "Exposure during pregnancy ": 2.387463909358403, "Extra dose 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51.74019821807413, "Hypoglycaemia unawareness ": 36.93383428644884, "Hypoglycaemic coma ": 41.795373610938746, "Hypoglycaemic encephalopathy ": 39.83663393846316, "Hypoglycaemic seizure ": 20.139371009611352, "Hypoglycaemic unconsciousness ": 30.217602853456096, "Impaired gastric emptying ": 3.4950962604679656, "Incorrect dose administered ": 7.256820448805883, "Incorrect dose administered by device ": 3.615381078273148, "Incorrect product administration duration ": 2.2071278027033023, "Increased appetite ": 3.617582583129311, "Induration ": 2.0574446513412665, "Injection site abscess ": 4.346093497176509, "Injection site atrophy ": 59.3583778629965, "Injection site bruising ": 3.16320127948626, "Injection site discolouration ": 2.850513707230089, "Injection site hypersensitivity ": 2.562349935823217, "Injection site induration ": 3.4630584056725904, "Injection site nodule ": 6.901422013170029, "Injection site urticaria ": 6.974209573713489, "Injury ": 4.161797213186596, "Injury associated with device ": 7.990588753491875, "Insulin C-peptide decreased ": 47.0287744961078, "Insulin C-peptide increased ": 88.05675507795686, "Insulin autoimmune syndrome ": 56.51647284079366, "Insulin resistance ": 46.788192016979416, "Intentional dose omission ": 2.867989424634064, "Intentional overdose ": 2.4416901290381143, "Jaundice neonatal ": 5.945557220737262, "Ketoacidosis ": 10.827389162752286, "Ketosis ": 7.870263036008226, "Left ventricular hypertrophy ": 2.7795099109884123, "Leg amputation ": 5.442274200635206, "Limb injury ": 2.186108042313221, "Lipoatrophy ": 23.663757305543054, "Lipodystrophy acquired ": 5.908147386209165, "Lipohypertrophy ": 17.42416003861978, "Localised infection ": 2.939278886159805, "Loss of consciousness ": 2.562426716071182, "Lower respiratory tract infection ": 3.3552902451283595, "Malnutrition ": 2.1410576600848086, "Maternal exposure before pregnancy ": 3.530598492227121, "Maternal exposure during pregnancy ": 2.608956472803196, "Medication error ": 2.3451829841043774, "Metabolic disorder ": 5.647429494658617, "Metabolic syndrome ": 8.453228637314536, "Microalbuminuria ": 8.421722293891142, "Multi-organ disorder ": 10.693664890472649, "Nasal congestion ": 4.406263090470182, "Onychoclasis ": 3.878152757668662, "Osteomyelitis ": 2.7158868217062246, "Pancreatic disorder ": 2.60432142302513, "Polydipsia ": 7.444265565416608, "Polyuria ": 2.833298156432316, "Post procedural complication ": 2.3076596515599186, "Postprandial hypoglycaemia ": 55.230240255555074, "Pre-eclampsia ": 11.98814642818381, "Premature baby ": 6.539373428793136, "Premature delivery ": 5.361874229152554, "Product dose omission issue ": 2.4047781865307924, "Product monitoring error ": 25.6958108516746, "Product selection error ": 15.763066581367177, "Product storage error ": 7.805098451626654, "Productive cough ": 5.007335850759927, "Prolonged expiration ": 289.7063554763469, "Pulmonary arterial hypertension ": 2.667830054051859, "Pulmonary mass ": 2.9107527809805624, "Rales ": 19.285108807716416, "Renal disorder ": 2.031210828396933, "Respiration abnormal ": 15.38942718038784, "Retinal detachment ": 2.797034573153604, "Retinopathy ": 5.291521094476115, "Rhinorrhoea ": 2.6004735713794456, "Road traffic accident ": 2.294145419942483, "Shock hypoglycaemic ": 11.428123004264917, "Shoulder fracture ": 2.421806964992624, "Skin induration ": 2.5252735423438306, "Skin mass ": 3.798412793941041, "Skin test positive ": 9.396483262519974, "Sleep disorder due to a general medical condition ": 6.922145763030374, "Starvation ": 17.351661479221224, "Stress ": 6.062002751662191, "Suspected suicide ": 4.049623959672664, "Systemic inflammatory response syndrome ": 3.1079166677180976, "Tearfulness ": 2.421532172463406, "Toe amputation ": 5.3542382786218745, "Treatment noncompliance ": 4.472495109248133, "Type 1 diabetes mellitus ": 3.422614382687812, "Type I hypersensitivity ": 5.945508902729597, "Type III immune complex mediated reaction ": 21.882097754320576, "Unresponsive to stimuli ": 3.919987084233172, "Upper respiratory tract infection ": 5.101732254187432, "Urine ketone body present ": 8.979123534650236, "Vascular stent stenosis ": 19.344187943222632, "Visual impairment ": 2.7469159900887696, "Weight decreased ": 2.3738986328777982, "Weight increased ": 3.5900499778113524, "Weight loss poor ": 4.223975719980431, "Wheezing ": 2.13265936460401, "Wrong product administered ": 13.548708694450076, "Wrong technique in product usage process ": 4.567874105726318} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/577.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/577.json new file mode 100644 index 00000000000..057b90bd2b9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/577.json @@ -0,0 +1 @@ +{"Agitation ": 2.8593307225004563, "Blood glucose abnormal ": 32.15073150275138, "Blood glucose decreased ": 11.79215330665054, "Blood glucose fluctuation ": 44.4145866971573, "Blood glucose increased ": 24.24844516194957, "Dermatitis allergic ": 8.394612998488647, "Diabetes mellitus inadequate control ": 21.62515435482284, "Drug ineffective ": 3.0906429195403438, "Hyperglycaemia ": 18.465977341689065, "Hypersensitivity ": 3.874387570730978, "Hypoglycaemia ": 28.73926687814118, "Hypoglycaemic coma ": 35.20144740261754, "Ketoacidosis ": 14.836894349817989, "Loss of consciousness ": 2.26309896866658, "Product complaint ": 8.109223304435012, "Product quality issue ": 8.006479920118634, "Product storage error ": 22.20525235270007, "Pruritus ": 2.445623142025537, "Shock hypoglycaemic ": 565.3150908164297, "Stevens-Johnson syndrome ": 6.057229131990138, "Therapeutic response decreased ": 6.439673970069999} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/578.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/578.json new file mode 100644 index 00000000000..5b4e9091685 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/578.json @@ -0,0 +1 @@ +{"Acute myocardial infarction ": 3.835703028270673, "Atelectasis ": 13.599422902071366, "Blood creatinine increased ": 2.3902030808793446, "Bradycardia ": 2.885982502303168, "Cardiac arrest ": 3.996731613952982, "Cardiac tamponade ": 35.392869542997, "Cardiogenic shock ": 27.601603830101084, "Cerebral haemorrhage ": 13.394588598119425, "Coronary artery disease ": 5.419246917653654, "Coronary artery occlusion ": 13.338233526765263, "Coronary artery thrombosis ": 179.42443305229153, "Death ": 3.205497284453947, "Depressed level of consciousness ": 2.8342548527553384, "Epistaxis ": 3.374395580793081, "Gastrointestinal haemorrhage ": 7.035055564647983, "Gingival bleeding ": 9.913264867442908, "Haematemesis ": 15.604528776443608, "Haematocrit 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5.1737116660134, "Retroperitoneal haemorrhage ": 163.9798936559638, "Shock ": 6.224400534317862, "Thrombocytopenia ": 21.05797244707951, "Thrombosis ": 10.43120476899411, "Thrombosis in device ": 57.21520619148361, "Unresponsive to stimuli ": 7.2337051250587505, "Vascular stent thrombosis ": 27.102178320942453} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/579.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/579.json new file mode 100644 index 00000000000..e0fdc639fac --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/579.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 4.546432581542087, "Anaemia ": 2.842822682133357, "Blindness ": 3.709520722607151, "Blood cholesterol increased ": 5.019847277198758, "Blood creatine phosphokinase increased ": 3.475451418412697, "Blood magnesium increased ": 196.05906906058885, "Drug interaction ": 3.205641610300448, "Drug level increased ": 6.767579741795777, "Drug reaction with eosinophilia and systemic symptoms ": 7.953675493072498, "Drug resistance ": 5.547178033788962, "Dysarthria ": 3.421208629107179, "Exposure during pregnancy ": 7.613149553509169, "Eye pain ": 2.7160391488955344, "Foetal exposure during pregnancy ": 10.041149469213378, "Gait disturbance ": 3.419045602104735, "H1N1 influenza ": 147.18136326792742, "Hepatic cirrhosis ": 10.659739972018835, "Hypercholesterolaemia ": 20.331408852927524, "Lipodystrophy acquired ": 57.52824164423886, "Lung lobectomy ": 392.0162968566276, "Maternal exposure during pregnancy ": 4.846197871679369, "Mitochondrial DNA depletion ": 4803.567854497512, "Mitochondrial myopathy acquired ": 1634.87883964271, "Mitochondrial toxicity ": 108.03239645820874, "Mobility decreased ": 2.588487564792472, "Multiple organ dysfunction syndrome ": 3.835737953232934, "Myocardial infarction ": 2.15311431672718, "Nervous system disorder ": 17.010059857792, "Neuropathy peripheral ": 9.49992055615028, "Neurotoxicity ": 19.471394046635037, "Pancreatitis acute ": 3.90052859478247, "Pollakiuria ": 12.124317213615468, "Rash maculo-papular ": 6.353346421745764, "Rash pruritic ": 3.1398908464701853, "Red blood cell count decreased ": 6.131405407137554, "Renal failure ": 2.137193343868846, "Renal tubular disorder ": 36.19940474362985, "Sleep disorder ": 2.466520317712088, "Toxic skin eruption ": 8.470208755337556, "Vitamin B6 deficiency ": 853.9363846056168} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/58.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/58.json new file mode 100644 index 00000000000..6fefaaed9ca --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/58.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 5.256692338989005, "Alopecia ": 3.578587789463588, "Altered state of consciousness ": 6.640526091070373, "Aspartate aminotransferase increased ": 6.008725020825621, "Blood alkaline phosphatase increased ": 11.42816061559514, "Blood bilirubin increased ": 9.843290135730951, "Cholestasis ": 19.729984872759196, "Constipation ": 2.518250336260491, "Depressed level of consciousness ": 5.137880036911207, "Drug-induced liver injury ": 9.20669275288271, "Electrocardiogram QT prolonged ": 8.226379892404765, "Febrile neutropenia ": 7.775614210119801, "Haemolysis ": 91.04718887035745, "Hepatic enzyme increased ": 8.90267033169458, "Hypersensitivity ": 2.270165281457616, "Hypokalaemia ": 4.068647694150727, "Hyponatraemia ": 3.203744470085851, "Hypophagia ": 23.469966448367465, "Interstitial lung disease ": 6.442653242552805, "Jaundice ": 15.536059121445389, "Muscle spasms ": 2.592170907969974, "Neutropenia ": 2.164915742137972, "Palmar-plantar erythrodysaesthesia syndrome ": 13.355275236298018, "Wheezing ": 4.280106120179919} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/580.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/580.json new file mode 100644 index 00000000000..5cf3c42a9cc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/580.json @@ -0,0 +1 @@ +{"Anaemia ": 5.019918709679311, "Depression ": 4.6108796678941, "Haemoglobin decreased ": 3.020494907266305, "Haemolytic anaemia ": 11.715555197298055, "Hepatic cirrhosis ": 8.66354073960194, "Hepatic failure ": 5.082185707007766, "Hyperthyroidism ": 10.791029692140649, "Hypothyroidism ": 9.94358682446966, "Lethargy ": 3.350577336109295, "Neutropenia ": 2.912193502400345, "Pancytopenia ": 2.5271831823825943, "Platelet count decreased ": 2.8186379042981486, "Rash pruritic ": 2.303674630269364, "Sleep disorder ": 2.004626325889361, "Therapy non-responder ": 9.763489066226768, "Weight decreased ": 3.0075023352844235, "White blood cell count decreased ": 3.9589913980705234} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/581.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/581.json new file mode 100644 index 00000000000..8dc257e122c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/581.json @@ -0,0 +1 @@ +{"Abortion induced ": 12.54486533736513, "Affect lability ": 10.212844626797075, "Aggression ": 4.181127741410827, "Altered state of consciousness ": 2.092654666118045, "Amnesia ": 2.357081350582774, "Anaemia ": 8.87785976906131, "Ascites ": 5.518125061279705, "Blood lactate dehydrogenase increased ": 2.900355183044035, "Blood thyroid stimulating hormone increased ": 7.019218225295544, "Bronchitis ": 2.483175165673872, "Central venous catheterisation ": 23.25685931960968, "Cerebral haemorrhage ": 4.178954828261928, "Cerebral infarction ": 2.615170887647368, "Cognitive disorder ": 2.153039032474172, "Colitis 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/583.json @@ -0,0 +1 @@ +{"Agitation ": 4.851999173345048, "Clostridium difficile colitis ": 75.26220815004392, "Clostridium difficile infection ": 24.28068171944017, "Clostridium test positive ": 354.08815233641167, "Confusional state ": 8.610774818277607, "Delirium ": 16.920843032439628, "Drug interaction ": 2.097861440581754, "Drug reaction with eosinophilia and systemic symptoms ": 13.5146753479387, "Epilepsy ": 6.104987061503228, "Hallucination ": 19.473425428213435, "Neutropenia ": 2.096129273746712, "Rash maculo-papular ": 5.624801001344587, "Seizure ": 7.380376883964889, "Speech disorder ": 7.385535311030932, "Thrombocytopenia ": 2.6761412178833583} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/584.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/584.json new file mode 100644 index 00000000000..bd0fcf89b15 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/584.json @@ -0,0 +1 @@ +{"Abnormal weight gain ": 36.4521364922043, "Adverse drug reaction ": 4.44714800354435, "Aggression ": 7.991755507224294, "Agitation ": 4.644737778963431, "Akathisia ": 12.6583957862369, "Amenorrhoea ": 7.892499593476063, "Blood creatine phosphokinase increased ": 4.477519818808439, "Blood prolactin increased ": 141.64254342732255, "Breast enlargement ": 50.34546184779829, "Completed suicide ": 2.699931216496802, "Delusion ": 15.1523578975482, "Depressed mood ": 2.52863582089115, "Drug interaction ": 3.5823003638213358, "Dyskinesia ": 17.41556131767222, "Dystonia ": 18.64753383363957, "Dysuria ": 10.765802833813297, "Electrocardiogram QT prolonged ": 4.219308430202351, "Emotional disorder ": 11.593336288808644, "Extrapyramidal disorder ": 30.399788263878825, "Galactorrhoea ": 68.16745256660197, "Genital neoplasm malignant female ": 903.5286584417336, "Gynaecomastia ": 92.28047410441224, "Hallucination, auditory ": 17.692620719746742, "Hyperprolactinaemia ": 132.46205883078724, "Hypersomnia ": 6.01207201922781, "Inappropriate schedule of product administration ": 2.195184496674329, "Insomnia ": 2.1794372703530467, "Intentional overdose ": 10.229395938062794, "Intentional product misuse ": 2.4435521690193496, "Musculoskeletal stiffness ": 2.40739109565096, "Neuroleptic malignant syndrome ": 21.885678113490577, "Obesity ": 38.05853944663191, "Oculogyric crisis ": 29.95337294481709, "Off label use ": 2.035226561542561, "Overdose ": 2.735138234345458, "Parkinsonism ": 21.79121037476481, "Pneumonia aspiration ": 6.268929403487217, "Product use in unapproved indication ": 2.688067854004403, "Psychotic disorder ": 8.494303453081656, "Restlessness ": 2.839941153735127, "Rhabdomyolysis ": 2.0660382432029314, "Salivary hypersecretion ": 18.883259056039243, "Schizophrenia ": 26.52068628790617, "Sedation ": 9.30208094922216, "Sedation complication ": 41.62991226636201, "Self-destructive behaviour ": 122.61966924730778, "Sluggishness ": 22.562687853543807, "Somnolence ": 2.9298820006767348, "Sopor ": 21.06219722126083, "Suicidal ideation ": 2.302649916692346, "Suicide attempt ": 7.447787336658952, "Tardive dyskinesia ": 54.95648117928224, "Therapeutic product effect decreased ": 2.461156267610725, "Treatment noncompliance ": 15.917303404009376, "Tremor ": 3.6036109735638258, "Urinary retention ": 2.343642392080649, "Weight increased ": 9.115944954372004} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/585.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/585.json new file mode 100644 index 00000000000..fd9ee2c8cec --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/585.json @@ -0,0 +1 @@ +{"Dehydration ": 11.001925952899311, "Fall ": 3.424470923795649} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/586.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/586.json new file mode 100644 index 00000000000..af2b7040993 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/586.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.929645119649085, "Alanine aminotransferase increased ": 3.948482937859788, "Anaemia ": 3.033202596108638, "Angina unstable ": 31.72654167313184, "Aspartate aminotransferase increased ": 3.5779151390378616, "Blood cholesterol increased ": 3.8154871284687326, "Blood creatine phosphokinase increased ": 3.2467921984801187, "Blood lactic acid increased ": 48.75450212338035, "Blood triglycerides increased ": 23.748769832251284, "Diabetes mellitus ": 13.702374618233254, "Diabetic ketoacidosis ": 4.30234548388804, "Drug interaction ": 3.834601339199678, "Dysgeusia ": 2.7742211693576886, "Gamma-glutamyltransferase increased ": 3.3824270447191336, "Hepatic cirrhosis ": 7.95494270063493, "Hepatic enzyme increased ": 2.0586104908299965, "Hepatic failure ": 8.932145023673755, "Hepatitis ": 10.170352798083334, "Hepatomegaly ": 20.812618482064707, "Hepatotoxicity ": 6.083870705208882, "Hypercholesterolaemia ": 29.71684111750704, "Hyperglycaemia ": 2.6513000513292195, "Hypertriglyceridaemia ": 119.9334095543476, "Hypokalaemia ": 3.1373967681054253, "Hypotonia ": 7.923019980290586, "Jaundice ": 4.303744149156755, "Lactic acidosis ": 13.189574486225942, "Lipodystrophy acquired ": 107.48170491901207, "Live birth ": 14.963944881939105, "Liver function test abnormal ": 5.967640076123396, "Mitochondrial cytopathy ": 188.1958555668036, "Myocardial infarction ": 3.1964369748732766, "Neuropathy peripheral ": 2.645611189398636, "Neutropenia ": 4.177826260180009, "Osteonecrosis ": 3.397353505165784, "Pancreatitis ": 6.803109053075297, "Pancreatitis acute ": 6.8706616635760085, "Premature baby ": 5.12318380530117, "Pulmonary hypertension ": 6.968597543299654, "Renal failure ": 2.257577482001422, "Rhabdomyolysis ": 3.908097216322319, "Sepsis ": 2.112004244115168, "Stevens-Johnson syndrome ": 5.18114460238931, "Thrombocytopenia ": 2.3111658922009344, "Transaminases increased ": 4.9240327138088205} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/587.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/587.json new file mode 100644 index 00000000000..696486a2805 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/587.json @@ -0,0 +1 @@ +{"Abnormal loss of weight ": 10.850415787038829, "Accidental exposure to product by child ": 16.224040042189866, "Acute kidney injury ": 40.850707409584885, "Acute respiratory failure ": 16.90788920558382, "Amputation ": 212.1455539523325, "Asthma-chronic obstructive pulmonary disease overlap syndrome ": 89.93854887139695, "Blood glucose decreased ": 4.678144224379471, "Bronchiectasis ": 9.1888848388842, "Cellulitis ": 16.604928654713408, "Dehydration ": 9.037702670351509, "Diabetes mellitus inadequate control ": 9.360549912086556, "Diabetic foot ": 349.4085678851333, "Diabetic foot infection ": 1113.6493314067463, "Diabetic ketoacidosis ": 245.70819420025737, "Dry gangrene ": 226.4341849909896, "Encephalopathy ": 6.227337894992647, "Euglycaemic diabetic ketoacidosis ": 51.56630694276225, "Foot amputation ": 567.3089878642406, "Fournier's gangrene ": 29.700321249119792, "Full blood count abnormal ": 6.299675955740804, "Fungal infection ": 5.835271486718919, "Gangrene ": 117.15922691018568, "Gas gangrene ": 273.96623485230424, "Gastroenteritis ": 5.524572912058302, "Gastrooesophageal reflux disease ": 3.2746162923476883, "Glycosylated haemoglobin increased ": 5.355835441293127, "Hyperglycaemia ": 4.322530604586033, "Hyperkalaemia ": 4.750934652391743, "Hypoglycaemia ": 2.6032883215117533, "Incorrect dose administered ": 5.309192184949658, "Ketoacidosis ": 49.04761660825751, "Kidney infection ": 6.30676188283176, "Lactic acidosis ": 4.822680612783729, "Leg amputation ": 213.12920258511377, "Leukocytosis ": 6.739419834490064, "Limb amputation ": 464.515703934641, "Localised infection ": 4.982933844170973, "Metabolic acidosis ": 35.09673005468178, "Metabolic encephalopathy ": 54.81103034817952, "Metatarsal excision ": 1190.3828331667223, "Multiple allergies ": 19.399175792702227, "Mycobacterial infection ": 42.24188768373045, "Myocardial infarction ": 2.8731209675729468, "Necrotising fasciitis ": 48.16911737572099, "Obesity ": 4.619202327250742, "Obstructive airways disorder ": 3.8711505949287215, "Osteomyelitis ": 148.59832760374488, "Osteomyelitis acute ": 466.94296709079504, "Pancreatitis ": 5.049986261556998, "Pancreatitis acute ": 6.816723529365103, "Pollakiuria ": 2.1351278355626984, "Pyelonephritis ": 20.150744044135763, "Renal abscess ": 85.79578053450582, "Renal failure ": 3.2654391480733995, "Renal injury ": 2.2548012230903014, "Renal tubular necrosis ": 6.47294286560612, "Respiratory failure ": 2.64167759161365, "Sepsis ": 9.41449086248998, "Septic shock ": 8.617050485520519, "Skin ulcer ": 12.8946572172465, "Systemic inflammatory response syndrome ": 30.685230243135727, "Toe amputation ": 504.1782489129577, "Treatment noncompliance ": 20.74200184961655, "Type 2 diabetes mellitus ": 10.16238964797084, "Urinary tract infection ": 8.990498459148343, "Urosepsis ": 53.23538028705553, "Vulvovaginal mycotic infection ": 25.288627745971905, "Weight decreased ": 2.949246785447349} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/588.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/588.json new file mode 100644 index 00000000000..a4a6dcfe61c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/588.json @@ -0,0 +1 @@ +{"Addison's disease ": 33.41518997901263, "Adrenal insufficiency ": 27.10040061042941, "Adrenalitis ": 221.59627095045536, "Adrenocortical insufficiency acute ": 14.090822527498725, "Adrenocorticotropic hormone deficiency ": 68.06164462891408, "Amylase increased ": 2.085031515863356, "Aplasia pure red cell ": 2.784467066528548, "Aplastic anaemia ": 2.486168795344502, "Arthritis ": 5.236890875852426, "Autoimmune arthritis ": 63.58495963716963, "Autoimmune colitis ": 325.5770944991305, "Autoimmune haemolytic anaemia ": 13.880022687975002, "Autoimmune hepatitis ": 51.54027169247216, "Autoimmune hypothyroidism ": 47.27680113505468, "Autoimmune nephritis ": 190.2043671983852, "Autoimmune pancreatitis ": 64.7715477480444, "Autoimmune thyroiditis ": 24.84058458649042, "Capillary leak syndrome ": 9.122397677917748, "Chronic gastritis ": 8.301569175555496, "Clostridium difficile infection ": 2.508613837488696, "Colitis ": 66.1042328423263, "Cortisol decreased ": 7.824902358335052, "Cutaneous vasculitis ": 5.026146201745092, "Cytokine release syndrome ": 2.778727039835094, "Dermatitis ": 5.698068196672309, "Diabetes mellitus ": 2.712612978953228, "Diabetic ketoacidosis ": 6.098810213645955, "Diarrhoea ": 2.1876275852311524, "Diarrhoea haemorrhagic ": 2.286442173828978, "Drug-induced liver injury ": 2.5067612910556094, "Duodenitis ": 20.940303671947945, "Encephalitis ": 10.559856827701788, "Encephalitis autoimmune ": 26.694867674898703, "Endocrine disorder ": 34.18757059239579, "Enteritis ": 12.609878247950771, "Enterocolitis ": 14.18662319144116, "Fulminant type 1 diabetes mellitus ": 51.11545576917631, "Gastritis ": 2.79945464102805, "Giant cell arteritis ": 9.109378620817504, "Glomerulonephritis ": 11.684935902526489, "Glucocorticoid deficiency ": 93.33687687709478, "Granuloma ": 6.016820916352349, "Guillain-Barre syndrome ": 7.194192879250318, "Haemophagocytic lymphohistiocytosis ": 11.841191342117146, "Hepatic cytolysis ": 2.302952221648148, "Hepatic lesion ": 4.6931242684799095, "Hepatitis ": 25.422253598697, "Hepatitis acute ": 2.208515980355958, "Hepatotoxicity ": 18.084465198137583, "Hyperthyroidism ": 14.384329526311053, "Hypertransaminasaemia ": 13.398479899659156, "Hypomagnesaemia ": 3.41010329683911, "Hypophysitis ": 486.2967077921366, "Hypopituitarism ": 88.60814365829427, "Hypothalamo-pituitary disorder ": 17.266786365829507, "Hypothyroidism ": 13.434881726666614, "Immune thrombocytopenia ": 6.658732495992841, "Immune-mediated adrenal insufficiency ": 39.4604514723791, "Immune-mediated adverse reaction ": 66.64906496063064, "Immune-mediated arthritis ": 78.92881584574202, "Immune-mediated dermatitis ": 98.94122353716833, "Immune-mediated encephalitis ": 284.9756724361475, "Immune-mediated enterocolitis ": 296.79190779537004, "Immune-mediated gastritis ": 154.62525109794524, "Immune-mediated hepatic disorder ": 32.07000010915875, "Immune-mediated hepatitis ": 388.0625496062652, "Immune-mediated hyperthyroidism ": 56.0123608654396, "Immune-mediated hypophysitis ": 856.2227396132345, "Immune-mediated hypothyroidism ": 44.30409769261316, "Immune-mediated lung disease ": 130.25320983857247, "Immune-mediated myasthenia gravis ": 105.08007748062978, "Immune-mediated myocarditis ": 229.4228018276204, "Immune-mediated myositis ": 106.29353756716668, "Immune-mediated nephritis ": 268.11830719659974, "Immune-mediated neuropathy ": 162.24804260204309, "Immune-mediated pancreatitis ": 89.0312362604972, "Immune-mediated thyroiditis ": 349.93941749374187, "Immune-mediated uveitis ": 237.77810539460356, "Intentional product use issue ": 19.045617853119158, "Intestinal perforation ": 8.507515880975806, "Iridocyclitis ": 29.247058088192155, "Kidney transplant rejection ": 7.308882660852478, "Large intestine perforation ": 14.1312095025065, "Lichenoid keratosis ": 13.016764537000531, "Lipase increased ": 4.333568386422847, "Lymphocytic hypophysitis ": 558.4777228864215, "Malignant melanoma ": 2.930529179041703, "Malignant neoplasm progression ": 27.755525810245462, "Melanoma recurrent ": 40.76271445567616, "Meningitis ": 3.548983673908793, "Meningitis aseptic ": 8.047001915998338, "Metastases to central nervous system ": 17.19086188377956, "Metastases to liver ": 2.2836365542458195, "Metastases to lung ": 6.438861607838036, "Metastases to lymph nodes ": 4.478887375105418, "Metastasis ": 4.070435754520704, "Metastatic malignant melanoma ": 21.94798157927847, "Myasthenia gravis ": 22.77116436963525, "Myasthenic syndrome ": 30.15867478453428, "Myocarditis ": 8.622128064118565, "Myopathy ": 4.157478503697465, "Myositis ": 23.00058399342101, "Nephritis ": 23.81096487403195, "Non-small cell lung cancer ": 14.374157110331277, "Off label use ": 2.4471945765108334, "Optic neuritis ": 6.291091398036157, "Orbital myositis ": 162.43734978402895, "Organising pneumonia ": 3.560433136185261, "Pancreatic enzymes increased ": 10.572297065075528, "Pemphigoid ": 7.308260249922632, "Peritonitis ": 2.2190722713139697, "Pneumocystis jirovecii pneumonia ": 2.082410976904716, "Pneumonitis ": 28.607869287609, "Polyarthritis ": 11.23661901865747, "Polymyalgia rheumatica ": 4.715348616344248, "Polymyositis ": 11.325017009955308, "Polyneuropathy ": 5.290614128625591, "Prescribed overdose ": 3.019148756330173, "Prescribed underdose ": 4.603506628675699, "Primary hypothyroidism ": 55.39933377858444, "Pulmonary mass ": 2.518144752577629, "Pulmonary toxicity ": 5.0893657882930885, "Radiation necrosis ": 112.07697226903947, "Radiculopathy ": 2.3856552349305784, "Rash maculo-papular ": 2.661380821192988, "Sarcoidosis ": 10.22796560870914, "Secondary adrenocortical insufficiency ": 57.4108844572086, "Sjogren's syndrome ": 11.430293049913464, "Skin toxicity ": 16.529410227504226, "Thyroid disorder ": 4.45171356922315, "Thyroiditis ": 70.05052279764486, "Thyrotoxic crisis ": 16.00775582564924, "Toxic epidermal necrolysis ": 3.686371464834559, "Transaminases increased ": 2.4478468231851984, "Transfusion ": 2.311058722106648, "Tubulointerstitial nephritis ": 11.279064762142358, "Tumour pseudoprogression ": 61.98276320803039, "Type 1 diabetes mellitus ": 39.60417912390341, "Uveitis ": 10.417910022718075, "Vasculitis ": 2.4205366342644146, "Vitiligo ": 112.66543173819584, "Vogt-Koyanagi-Harada disease ": 30.65577505972935} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/589.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/589.json new file mode 100644 index 00000000000..3c06696c6c0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/589.json @@ -0,0 +1 @@ +{"Acidosis ": 3.19258373693702, "Acute kidney injury ": 11.958328500161532, "Adjustment disorder ": 11.864618588958349, "Affect lability ": 2.239939030146136, "Angioedema ": 5.969298027062175, "Anuria ": 6.395079655963421, "Aortic aneurysm ": 7.628220743712314, "Arteriosclerosis coronary artery ": 3.5859000766069, "Atrial fibrillation ": 2.92151138269778, "Atrioventricular block first degree ": 7.00850753482841, "Autoimmune hepatitis ": 4.1307925051756245, "Blood calcium abnormal ": 24.73191768451817, "Blood immunoglobulin E increased ": 14.168890113224784, "Blood potassium increased ": 6.435437934543185, "Blood pressure decreased ": 2.23204754147208, "Blood pressure inadequately controlled ": 10.563412562667695, "Blood pressure increased ": 2.8352459456034658, "Blood pressure systolic increased ": 5.592911012115222, "Blood sodium decreased ": 3.6257053742040894, "Blood thyroid stimulating hormone abnormal ": 45.9891528125131, "Body temperature decreased ": 4.212431284272316, "Bradycardia ": 3.619958624820904, "Brain natriuretic peptide abnormal ": 169.5080842160149, "Bundle branch block left ": 13.32397131700644, "Bundle branch block right ": 9.853010291316506, "Cardiac failure chronic ": 7.355031865143697, "Cardio-respiratory arrest ": 4.064952929141512, "Cardiogenic shock ": 5.037826818911573, "Cardiomegaly ": 4.026338499462886, "Cell death ": 22.00405209910552, "Choking ": 2.3272563654825715, "Cholestasis ": 3.539711827522515, "Concussion ": 5.549178584198931, "Conduction disorder ": 19.92712319398857, "Coordination abnormal ": 2.2069641789403747, "Dehydration ": 3.490297988187772, "Drug interaction ": 3.389479153505028, "Drug reaction with eosinophilia and systemic symptoms ": 2.2737388779374763, "Dysgeusia ": 2.042372789268117, "Dyslipidaemia ": 7.435931195961746, "Dysmetria ": 134.92989091020652, "Eczema ": 3.2869846394520734, "Ejection fraction decreased ": 3.929027789832991, "Electrocardiogram QRS complex abnormal ": 97.0310900613415, "Electrocardiogram QT prolonged ": 3.7484294569976098, "Electrolyte imbalance ": 3.688027549686892, "Eosinophilia ": 5.285994348254948, "Expanded disability status scale score increased ": 97.23315952462826, "Extra dose administered ": 3.3056372428490173, "Extrapyramidal disorder ": 2.114318540252831, "Extrasystoles ": 6.926790779835981, "Fall ": 3.863718671286468, "Fluid 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"Leukocytosis ": 2.4007062342222567, "Lip swelling ": 2.3642070817755774, "Lymphoedema ": 4.704948622008581, "Lymphopenia ": 9.354812321814732, "Metabolic acidosis ": 3.1010784619048923, "Mitral valve incompetence ": 6.211170183147972, "Muscle spasticity ": 16.24827066279386, "Muscular weakness ": 2.541352237650241, "Musculoskeletal discomfort ": 9.953365071502423, "N-terminal prohormone brain natriuretic peptide abnormal ": 400.94499438346753, "Nodal rhythm ": 13.49443218263164, "Obstructive airways disorder ": 2.5180717189263224, "Obstructive sleep apnoea syndrome ": 34.4898290623038, "Oedema peripheral ": 2.9372207252676663, "Oliguria ": 3.6716842470271143, "Orthostatic hypotension ": 11.574113427824372, "Oxygen saturation increased ": 128.9482607467275, "Pemphigoid ": 5.745747651360943, "Photosensitivity reaction ": 2.862349617962733, "Poisoning ": 4.114685025399158, "Polydipsia ": 5.399581495360236, "Product substitution issue ": 15.6367401964026, "Pulmonary arterial pressure abnormal ": 167.3149328719622, "Pulmonary granuloma ": 33.05367305716744, "Rales ": 4.144111679596472, "Renal impairment ": 3.02852599958778, "Renal tubular necrosis ": 8.814977681348017, "Rhabdomyolysis ": 3.0272445906373364, "Shock ": 2.259259824064036, "Sinus arrest ": 9.985936513252224, "Sinus bradycardia ": 9.246055247944906, "Sinus node dysfunction ": 7.119084460301326, "Sleep apnoea syndrome ": 2.563521737044622, "Supraventricular extrasystoles ": 20.880086495906045, "Swollen tongue ": 3.1750382884388038, "Tachypnoea ": 3.276830169181945, "Therapeutic response unexpected ": 4.408580087441388, "Thyroiditis ": 5.78630768753406, "Torsade de pointes ": 11.290885564312942, "Tricuspid valve incompetence ": 10.79322902873088, "Troponin increased ": 5.932421160486333, "Tubulointerstitial nephritis ": 2.857486746749439, "Urinary incontinence ": 6.378393739002189, "Urine abnormality ": 47.405342593667335, "Urine output decreased ": 6.310746909011693, "Ventricular fibrillation ": 5.353085921616906, "Ventricular hypokinesia ": 9.683128779864218, "Wrong patient received product ": 25.572174983357847, "Wrong product administered ": 2.127178100957832, "Xerosis ": 27.237514801319797} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/59.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/59.json new file mode 100644 index 00000000000..2819937b50e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/59.json @@ -0,0 +1 @@ +{"Blood creatinine increased ": 2.401949180903367, "Blood glucose abnormal ": 9.06533303656946, "Blood glucose increased ": 5.336804459230629, "Bone lesion ": 144.37396459988793, "Breast cancer ": 18.173663496496665, "Breast cancer metastatic ": 78.26872288510475, "Colitis ": 12.057460787261917, "Decreased appetite ": 3.3957480849402053, "Diabetes mellitus ": 6.287278265310076, "Diabetic ketoacidosis ": 13.721487383478536, "Diarrhoea ": 3.3534145963512763, "Disease progression ": 3.180679690230368, "Glomerular filtration rate decreased ": 8.32963304444604, "Hepatic lesion ": 36.89639442563308, "Hyperglycaemia ": 66.83909950677229, "Ketoacidosis ": 12.542344745093494, "Malignant neoplasm progression ": 22.57815466307848, "Metastases to bone ": 86.4907984598958, "Metastases to central nervous system ": 24.052704377612688, "Metastases to liver ": 54.324832692377214, "Metastases to lung ": 23.682241113965883, "Mucosal inflammation ": 7.85130941763764, "Non-small cell lung cancer metastatic ": 332.6209519828068, "Rash ": 4.627759400842615, "Rash maculo-papular ": 4.030981195593474, "Therapy partial responder ": 19.354323675007983, "Weight decreased ": 3.1720607052156304} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/590.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/590.json new file mode 100644 index 00000000000..1265baa9e60 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/590.json @@ -0,0 +1 @@ +{"Acne ": 8.154198755526084, "Acquired gene mutation ": 69.7042989401872, "Acute respiratory distress syndrome ": 3.937171148402339, "Acute respiratory failure ": 6.8508167402690034, "Alanine aminotransferase increased ": 2.495375072118109, "Aspartate aminotransferase increased ": 2.36692328552314, "Atelectasis ": 2.4266284598894226, "Brain neoplasm ": 4.505140404453085, "Brain oedema ": 2.976459914054294, "Carcinoembryonic antigen increased ": 27.00912365139867, "Cerebral disorder ": 3.181319889664957, "Cerebral infarction ": 4.390647290760168, "Chest X-ray abnormal ": 4.587924595632598, "Cutaneous symptom ": 34.78099360469639, "Cystitis haemorrhagic ": 24.063605984710385, "Death ": 2.036537509337825, "Decreased appetite ": 2.722525946076958, "Dermatitis ": 6.059886490125115, "Dermatitis acneiform ": 54.42788815540443, "Diarrhoea ": 3.43195063160173, "Disease progression ": 7.2164889283722, "Disseminated intravascular coagulation ": 5.397030623116333, "Drug eruption ": 2.6541288295745358, "Drug resistance ": 70.67642715786374, "Drug tolerance ": 16.780137723758106, "Drug-induced liver injury ": 3.3954784381514456, "Dry skin ": 8.01838755447787, "EGFR gene mutation ": 107.23376182237224, "Eczema ": 2.935566774734069, "Enterocolitis ": 5.2064274348912765, "Gastric ulcer ": 2.239559524781864, "Gastrointestinal perforation ": 5.0569163625333, "Gene mutation ": 30.909304431817933, "Glossitis ": 7.513602512433928, "Haematuria ": 2.656481204132464, "Haemoptysis ": 4.967856209861063, "Hepatic cytolysis ": 2.3240790738734174, "Hepatic function abnormal ": 17.140323775773716, "Hepatotoxicity ": 2.3314064927057734, "Hydrothorax ": 39.81332002725986, "Hypertransaminasaemia ": 6.531480852162676, "Ileus ": 4.679579289264152, "Ingrowing nail ": 21.533846927067938, "Interstitial lung disease ": 76.98093674836446, "Intestinal obstruction ": 2.2174715403769296, "Leukoencephalopathy ": 9.047228067410376, "Liver disorder ": 12.835000063960898, "Liver function test abnormal ": 2.463257788588159, "Liver function test increased ": 2.6305809497949, "Lung carcinoma cell type unspecified recurrent ": 39.052140692189056, "Lung disorder ": 26.01572389184868, "Lung infiltration ": 2.9293397521386213, "Lung neoplasm malignant ": 3.717607999085944, "Lymphangiosis carcinomatosa ": 70.33819700889768, "Malignant neoplasm progression ": 24.02795548612873, "Malignant pleural effusion ": 29.596189572494023, "Metastases to bone ": 24.143152079819867, "Metastases to central nervous system ": 80.0331746628135, "Metastases to liver ": 6.638260761547869, "Metastases to lung ": 8.774142922998356, "Metastases to lymph nodes ": 13.49867076149224, "Metastases to meninges ": 79.9672614942064, "Metastases to pleura ": 33.3072167061144, "Metastases to spine ": 11.360625521153604, "Metastasis ": 31.50917039552248, "Mouth ulceration ": 2.9457374622225267, "Nail disorder ": 11.708200467416654, "Neoplasm progression ": 2.999499742324912, "Non-small cell lung cancer ": 4.371656697444121, "Non-small cell lung cancer recurrent ": 145.3852755723312, "Onychoclasis ": 7.312797983547702, "Paronychia ": 110.48531786560513, "Pericardial effusion ": 3.785930921858004, "Peritonitis ": 4.753691269167062, "Pleural effusion ": 8.540891072572432, "Pneumatosis intestinalis ": 22.450609301793232, "Pneumonia ": 2.139428720723449, "Pneumonia aspiration ": 2.309092362423352, "Pneumonia bacterial ": 10.327780174809508, "Pneumonitis ": 6.517559829522712, "Pneumothorax ": 7.775588441863413, "Pulmonary alveolar haemorrhage ": 5.783167906744686, "Pulmonary fibrosis ": 2.571176689742857, "Pulmonary mass ": 3.188748393657633, "Pulmonary toxicity ": 6.662793842786507, "Purpura ": 2.414375016645368, "Radiation pneumonitis ": 56.526177196016455, "Rash ": 3.925221401179489, "Rash pustular ": 6.458981539309405, "Respiratory failure ": 4.93282826126734, "Seborrhoeic dermatitis ": 13.181554866463816, "Skin disorder ": 6.348554775618841, "Skin exfoliation ": 3.332686353391652, "Skin fissures ": 8.94937851549259, "Skin toxicity ": 11.163595063292286, "Skin ulcer ": 3.319389773588747, "Small cell lung cancer ": 17.97279345992964, "Stomatitis ": 6.556163017751702, "Therapy cessation ": 4.548772475714912, "Transaminases increased ": 4.746103677619503, "Tumour marker increased ": 11.504208316702814} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/591.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/591.json new file mode 100644 index 00000000000..ca4ed5ee5d1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/591.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 7.02028029248467, "Adenocarcinoma of colon ": 17.633609204137816, "Alveolar rhabdomyosarcoma ": 809.095363387587, "Anaemia ": 4.21724541568401, "Ascites ": 2.861341402460185, "Bacteraemia ": 3.018778767065414, "Bone marrow failure ": 4.144558632726223, "Carcinoembryonic antigen increased ": 16.19176160584576, "Cholangitis ": 10.23539343616353, "Cholinergic syndrome ": 45.54563049917256, "Chronic myeloid leukaemia ": 8.468102811618309, "Clostridium difficile colitis ": 2.4549686799063744, "Clostridium difficile infection ": 2.914459738912785, "Colitis ": 3.789579376070665, "Colon cancer ": 2.704008684058976, "Colon cancer metastatic ": 33.925576121019446, "Colorectal cancer metastatic ": 84.34960623697118, "Conjunctivitis ": 2.4261047855747604, "Constipation ": 2.499488283847584, "Cytopenia ": 2.5352545830792703, "Decreased appetite ": 2.9431996599606234, "Dehydration ": 2.4579145116107908, "Dermatitis acneiform ": 29.70039445224959, "Diarrhoea ": 5.097742531287526, "Disease progression ": 10.474127506045225, "Dry skin ": 3.868846136362426, "Dysarthria ": 7.504346796065818, "Ejection fraction decreased ": 3.60207960532419, "Enteritis ": 9.125975784089093, "Febrile neutropenia ": 14.53730251034466, "Gastrointestinal anastomotic leak ": 173.61877673092252, "Gastrointestinal toxicity ": 38.52815494834213, "Gene mutation ": 18.496858498157557, "General physical health deterioration ": 2.2018751558980947, "Haematotoxicity ": 32.65306852212763, "Hepatic encephalopathy ": 2.5169210702850555, "Hiccups ": 5.818771108992019, "Hyperammonaemia ": 7.329392227312188, "Hyperammonaemic encephalopathy ": 12.274097157135747, "Hypertransaminasaemia ": 10.544836731464718, "Hypokalaemia ": 2.2057721660785337, "Hypomagnesaemia ": 13.327159290455429, "Hypophagia ": 2.191803076310809, "Interstitial lung disease ": 2.6600711935397268, "Intestinal obstruction ": 2.8129105644195618, "Laryngospasm ": 4.690793080988447, "Leukoencephalopathy ": 7.30531746594093, "Leukopenia ": 5.283762298689871, "Lymphopenia ": 2.2216070985987826, "Malignant neoplasm progression ": 5.222260454482672, "Metastases to bone ": 5.865332170718887, "Metastases to central nervous system ": 5.109625320999466, "Metastases to liver ": 15.964499057576887, "Metastases to lung ": 12.575021989705675, "Metastases to lymph nodes ": 8.794897011381536, "Metastases to meninges ": 23.15263988029885, "Metastases to peritoneum ": 23.422164326674043, "Mucosal inflammation ": 16.573972843345164, "Myelodysplastic syndrome ": 4.005118359848836, "Myelosuppression ": 8.368814537554545, "Neoplasm progression ": 2.9764128957703253, "Neuropathy peripheral ": 10.579335729935806, "Neurotoxicity ": 16.67839111290034, "Neutropenia ": 19.427079053478412, "Neutropenic colitis ": 18.142800601224515, "Neutropenic sepsis ": 7.595501674003464, "Neutrophil count decreased ": 7.718934545372097, "Pancreatic carcinoma ": 2.11987767332525, "Pancreatic carcinoma metastatic ": 17.032738931035393, "Pancreatic carcinoma recurrent ": 178.4899887026813, "Pancytopenia ": 2.556826257080924, "Paronychia ": 25.965644440670207, "Peripheral sensory neuropathy ": 24.741762827475803, "Peritonitis ": 3.411495994258846, "Polyneuropathy ": 4.645608137473361, "Portal hypertension ": 9.869382948144722, "Proteinuria ": 3.586411327871009, "Prothrombin time prolonged ": 3.5924468892495334, "Pulmonary mass ": 3.750846947698205, "Rash pustular ": 4.364527910255722, "Skin toxicity ": 32.088302184901224, "Small intestinal obstruction ": 8.47455593627557, "Stomatitis ": 7.914997377245134, "Temperature intolerance ": 4.284914392819486, "Therapeutic response decreased ": 2.702430180870288, "Therapy partial responder ": 13.26666594775564, "Thrombocytopenia ": 8.12578521797749, "Transaminases increased ": 2.120744121235689, "Vomiting ": 2.80682183458651, "White blood cell count decreased ": 3.281021485433438} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/592.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/592.json new file mode 100644 index 00000000000..12fb2eeb5ba --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/592.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 5.932005371640996, "Adverse event ": 5.139577155599635, "Adverse reaction ": 6.509293080257265, "Amnesia ": 2.7808194490059823, "Ankle fracture ": 6.864011722776922, "Antipsychotic drug level increased ": 41.64382396910717, "Arthritis infective ": 22.68599663096103, "Asthma ": 2.347636066606361, "Atrial fibrillation ": 2.0970978593117104, "Atrioventricular block first degree ": 25.392009194216357, "Blood iron decreased ": 15.697507529992688, "Brain fog ": 2.810825917073342, "Calciphylaxis ": 100.04045850853596, "Cardiac arrest ": 2.310532817045637, "Cardiac failure ": 2.221151480048332, "Chronic obstructive pulmonary disease ": 4.870584049920035, "Chronic spontaneous urticaria ": 54.45556841108845, "Clonus ": 18.02175576017883, "Coagulopathy ": 3.50709353019294, "Completed suicide ": 4.686805178073629, "Constipation ": 2.291443639283417, "Dementia Alzheimer's type ": 17.855250149778783, "Drug hypersensitivity ": 2.025163195910404, "Drug interaction ": 2.3218655313274223, "Electrocardiogram QT prolonged ": 3.152296753828457, "Exposure during pregnancy ": 3.869617154680877, "Fall ": 2.4801390998528263, "Foetal exposure during pregnancy ": 12.73538277520314, "Full blood count abnormal ": 2.4058601826710504, "Gastrooesophageal reflux disease ": 3.415932269904946, "Generalised oedema ": 4.682283903525589, "Haemoglobin decreased ": 2.18204567252758, "Head discomfort ": 5.230813008292253, "Heart rate decreased ": 3.366443240168534, "Hip surgery ": 28.855271783546023, "Hyperkalaemia ": 2.151128143043236, "Hypersomnia ": 4.946103305847822, "Hyperventilation ": 6.937358267364627, "Hypotension ": 2.093123428801628, "Implant site erosion ": 225.136020516175, "Implant site infection ": 83.09099201631, "Live birth ": 8.036657697663637, "Low birth weight baby ": 10.99021050548419, "Lower limb fracture ": 8.785541230540646, "Lower respiratory tract infection ": 2.4377833344801867, "Maternal exposure during pregnancy ": 4.415670321833552, "Meningitis ": 8.871124926098295, "Micturition disorder ": 20.092337341910685, "Muscle spasticity ": 10.26859269384046, "Obesity ": 4.898398896577418, "Pallor ": 2.503343024660426, "Premature baby ": 17.826570928774572, "Premature delivery ": 6.708356834204396, "Pulmonary hypertension ": 3.7427021417020616, "Purulent discharge ": 32.796400513698785, "Rash macular ": 2.133703944706537, "Respiratory distress ": 5.141985610462714, "Restlessness ": 2.4686466235699998, "Rib fracture ": 4.449471708752141, "Sinus disorder ": 13.942227610206992, "Sinusitis fungal ": 126.46166740720912, "Skin discolouration ": 3.336688381697896, "Sleep disorder due to a general medical condition ": 7.178404982553513, "Sputum discoloured ": 17.550379024374468, "Talipes ": 16.78504778320923, "Toxicity to various agents ": 4.852392448295709, "Umbilical cord around neck ": 116.6929442473178, "Vaginal infection ": 24.78797810159916, "Viral infection ": 3.604552430147829, "Wheezing ": 3.3635869350630774, "Wound dehiscence ": 40.43915961189301} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/593.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/593.json new file mode 100644 index 00000000000..5ce43c782d8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/593.json @@ -0,0 +1 @@ +{"Plasma cell myeloma ": 120.19680629071564} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/594.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/594.json new file mode 100644 index 00000000000..f5a289cc579 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/594.json @@ -0,0 +1 @@ +{"Anaemia ": 4.531429335375327, "C-reactive protein increased ": 3.014901573046446, "Cerebral haemorrhage ": 8.576455355686022, "Drug interaction ": 2.894287993349752, "Epistaxis ": 3.814543015058492, "Eye haemorrhage ": 10.8854025500992, "Gastric haemorrhage ": 21.5939574161558, "Gastric ulcer haemorrhage ": 115.956823658567, "Gastritis haemorrhagic ": 228.4518689559682, "Gastrointestinal haemorrhage ": 39.32767285319074, "Haematemesis ": 20.048102492198485, "Haematoma ": 12.559726952073577, "Haematuria ": 4.93785051987726, "Haemoglobin decreased ": 3.82535811680806, "Haemoptysis ": 6.329459482389591, "Haemorrhage ": 7.595728311471835, "Haemorrhage intracranial ": 9.673882097408493, "Hepatic enzyme increased ": 3.237199686355869, "Leukopenia ": 3.604698234888086, "Melaena ": 28.611045219608908, "Pallor ": 4.493169715650098, "Pancytopenia ": 4.426080489926366, "Thrombocytopenia ": 6.909080914656066} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/595.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/595.json new file mode 100644 index 00000000000..9ad69da8d4b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/595.json @@ -0,0 +1 @@ +{"Abortion induced ": 9.162201457621572, "Abortion spontaneous ": 12.24250372988332, "Acquired immunodeficiency syndrome ": 65.64099724312108, "Adverse event ": 13.672767539142034, "Alanine aminotransferase increased ": 6.043357164094914, "Amylase increased ": 5.3371456338815255, "Aphthous ulcer ": 2.501575915045517, "Ascites ": 3.734869467185293, "Aspartate aminotransferase increased ": 5.150247799503328, "Atypical mycobacterial infection ": 22.62733494897861, "Blood HIV RNA increased ": 39.31373695329639, "Blood creatine phosphokinase increased ": 3.477553295064985, "Bronchitis chronic ": 20.98660208660462, "CD4 lymphocytes decreased ": 26.003501328086987, "Caesarean section ": 36.925571071590014, "Cardiac murmur ": 8.520292731590207, "Cholecystitis ": 5.510024181886348, "Cholelithiasis ": 5.1784553714505845, "Cholestasis ": 2.490338253774196, "Circumstance or information capable of leading to medication error ": 5.293320770679062, "Coma ": 2.278509604914939, "Congenital choroid plexus cyst ": 266.1014655127313, "Congenital mitral valve incompetence ": 373.7811060545165, "Cushing's syndrome ": 11.231368778758927, "Cytomegalovirus infection ": 4.535876322948589, "Depression ": 2.0639384723199274, "Depressive symptom ": 11.597591479885814, "Dermatitis exfoliative generalised ": 3.798553611684029, "Drug interaction ": 2.310327312569482, "Drug reaction with eosinophilia and systemic symptoms ": 17.624554934903053, "Drug resistance ": 5.38515577992749, "Dyslipidaemia ": 6.097321143873284, "Dysphagia ": 5.4722149076176, "Dysphoria ": 8.71449070251109, "Encephalopathy ": 2.0612704461569376, "Endotracheal intubation ": 10.435015647090175, "Eosinophil count increased ": 3.574002247098945, "Eosinophilia ": 5.480044544994774, "Epididymitis ": 42.35530313205707, "Erectile dysfunction ": 3.071741528128123, "Exposure during pregnancy ": 10.722559134582214, "Foetal disorder ": 53.33145267081153, "Foetal exposure during pregnancy ": 19.56125128549391, "Foetal growth restriction ": 12.554921768447336, "Gastric ulcer ": 3.526647371371422, "Gastrointestinal tube insertion ": 67.17348963327188, "Gastrostomy ": 37.44770735181053, "Genotype drug resistance test positive ": 19.160371032956075, "Gynaecomastia ": 2.9017703011169007, "HIV infection ": 26.228616703695025, "Haemolytic anaemia ": 2.8637396476965136, "Haemorrhoids ": 3.199122225151042, "Hallucination, auditory ": 3.1728835138025038, "Hemivertebra ": 480.74761012803054, "Hepatic cirrhosis ": 2.346150348155201, "Hepatic cytolysis ": 12.560668733302348, "Hepatic failure ": 3.980495514478459, "Hepatitis ": 4.0609684490335285, "Hepatitis acute ": 3.0026870387222675, "Hepatitis toxic ": 6.906792872458438, "Hepatocellular injury ": 4.159450809627482, "Hernia ": 6.804357810188088, "Herpes simplex ": 6.228646950000963, "Hyperbilirubinaemia ": 7.20478294102445, "Hyperlipidaemia ": 2.985642116493356, "Hypertriglyceridaemia ": 5.462641043151266, "Immune reconstitution inflammatory syndrome ": 55.17842015193536, "Incorrect route of product administration ": 3.946916895007422, "Jaundice ": 3.0506423672595133, "Leukocytosis ": 2.2313904262082334, "Lipase increased ": 4.41054915562292, "Lipodystrophy acquired ": 43.97566010068277, "Live birth ": 3.944480221883075, "Liver disorder ": 3.51379628327106, "Liver function test increased ": 2.995057419059889, "Liver injury ": 2.133136484320288, "Low birth weight baby ": 15.759877556169904, "Lymphoma ": 5.141574378086152, "Maternal drugs affecting foetus ": 91.35380809590296, "Maternal exposure during pregnancy ": 11.888837358995266, "Maternal exposure timing unspecified ": 8.722990414245237, "Metabolic acidosis ": 3.129901270487822, "Myopathy ": 4.122208270356127, "Myositis ": 8.930839917029676, "Neoplasm malignant ": 2.0183941028081787, "Nephrolithiasis ": 2.047924234110237, "Neuropathy peripheral ": 2.822272546970999, "Neurotoxicity ": 3.297971421175697, "Nightmare ": 2.226080948038596, "No adverse event ": 4.618797466770805, "Osteonecrosis ": 2.1202904779640805, "Pancreatic mass ": 76.30225936932983, "Pancreatitis ": 2.135222387905285, "Pancreatitis acute ": 3.35181563404807, "Paralysis ": 2.2453383424932265, "Pathogen resistance ": 4.723258805631885, "Pericardial excision ": 302.50208192980966, "Peritonitis ": 3.822973430022648, "Pneumocystis jirovecii pneumonia ": 9.502252732514217, "Premature baby ": 12.093646925864116, "Premature delivery ": 11.003633827803116, "Premature labour ": 22.636597583884907, "Premature rupture of membranes ": 27.886813253642085, "Psychiatric decompensation ": 43.94282658421839, "Radiation skin injury ": 87.48984981283252, "Renal colic ": 9.77102354747226, "Renal disorder ": 2.0957692578020204, "Renal tubular disorder ": 10.860895955616668, "Respiratory distress ": 4.076777588753494, "Rhabdomyolysis ": 5.519433782463867, "Shock ": 2.222111338120247, "Small for dates baby ": 51.737514199448384, "Stillbirth ": 28.644168483602567, "Toxic skin eruption ": 2.8747360995195352, "Treatment noncompliance ": 3.653637147819361, "Vaginal discharge ": 2.997688628708564, "Ventricular hypertrophy ": 25.409631078271623, "Ventricular septal defect ": 18.74448073602423, "Viral load increased ": 10.083610546482534, "Viral mutation identified ": 21.07158443967743, "Virologic failure ": 14.332766554276567, "Volvulus ": 119.36599752473684, "Vulvovaginal burning sensation ": 16.996612894485715, "Wrong technique in product usage process ": 3.390004166111179} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/596.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/596.json new file mode 100644 index 00000000000..dcab0c0e146 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/596.json @@ -0,0 +1 @@ +{"Anaphylactoid reaction ": 19.088555070127462, "Blood cholesterol increased ": 5.851026675786622, "Blood creatine phosphokinase increased ": 5.515483665600753, "Blood creatinine increased ": 3.748518540921511, "Blood glucose abnormal ": 20.3566449972741, "Blood glucose increased ": 8.15665935778768, "Blood pressure decreased ": 3.3395468023104846, "Blood urea increased ": 27.438388995160302, "Cholestasis ": 10.343487952075716, "Diabetes mellitus ": 5.676870603236688, "Diabetes mellitus inadequate control ": 7.786595303256626, "Drug interaction ": 2.034121842989637, "Glycosylated haemoglobin increased ": 31.151325040449557, "Hyperglycaemia ": 5.706997139697428, "Hyperkalaemia ": 4.729444417139543, "Hypoglycaemia ": 19.694263748522214, "Renal failure ": 2.082694021944888} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/597.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/597.json new file mode 100644 index 00000000000..b88c03e1055 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/597.json @@ -0,0 +1 @@ +{"Asthenia ": 3.367752210476369, "Off label use ": 4.266268151282147} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/598.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/598.json new file mode 100644 index 00000000000..98c88a5168b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/598.json @@ -0,0 +1 @@ +{"Anaemia ": 4.288756872469929, "Angina pectoris ": 25.267803954709017, "Angina unstable ": 41.09930766440105, "Blood potassium increased ": 29.645190118139265, "Blood pressure decreased ": 6.565062096543902, "Blood pressure systolic decreased ": 83.14769727377978, "Bradycardia ": 12.921994780117796, "Cardiac failure ": 17.531825338352988, "Contusion ": 12.236948448083806, "Dilated cardiomyopathy ": 92.9027951113865, "Drug interaction ": 6.116985375865525, "Dyspnoea exertional ": 4.994070997371184, "ECG signs of myocardial ischaemia ": 1124.7900986023074, "Ejection fraction decreased ": 24.22491825993602, "Electrocardiogram QT prolonged ": 14.944706497890229, "Fluid retention ": 32.60789961809711, "Glomerular filtration rate decreased ": 26.640445622249874, "Hypotension ": 11.063205398549536, "Intentional self-injury ": 17.022503347519358, "Mental disorder ": 9.96525652703948, "Mitral valve incompetence ": 35.82421899676855, "N-terminal prohormone brain natriuretic peptide increased ": 80.44381262534556, "Oedema peripheral ": 18.086521302271574, "Personality disorder ": 98.99076893959575, "Presyncope ": 19.74648643544044, "Psoriasis ": 22.570009125551728, "Pulmonary oedema ": 33.54157949263872, "Rales ": 30.680095877063952, "Schizophrenia ": 36.06121745877247, "Sinus arrest ": 169.8045097608625, "Sinus bradycardia ": 61.21954376347272, "Suicide attempt ": 5.841694981373992, "Torsade de pointes ": 14.452431858859548, "Treatment failure ": 5.770739571380053, "Venous pressure jugular increased ": 909.621439087268, "Ventricular arrhythmia ": 45.93901715551617, "Ventricular dysfunction ": 749.0346955618561, "Ventricular extrasystoles ": 17.103482821467775, "Ventricular fibrillation ": 13.381774976491432} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/599.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/599.json new file mode 100644 index 00000000000..424a7a03e8f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/599.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 15.199951144193657, "Dry eye ": 77.82005651515487, "Insomnia ": 9.916105429983393, "Rash ": 6.043010574963553} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/6.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/6.json new file mode 100644 index 00000000000..c8ab0030ee3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/6.json @@ -0,0 +1 @@ +{"Anaemia ": 2.4617573956389687, "Blood bilirubin increased ": 6.925106015555614, "Breast cancer metastatic ": 93.15999432842683, "Diarrhoea ": 3.853968209491729, "Disease progression ": 3.1412143460413438, "Malignant neoplasm progression ": 17.71103368606872, "Metastases to bone ": 81.60225083279639, "Metastases to liver ": 45.60456660337498, "Metastases to lung ": 37.63510260335623, "Metastatic neoplasm ": 107.1257911622265, "Myelosuppression ": 20.66017116223991, "Neuropathy peripheral ": 3.653176115903396, "Neutropenia ": 4.333271677969338, "Neutrophil count decreased ": 5.8981201708660285, "Platelet count decreased ": 5.768634076520544, "Tumour marker increased ": 96.50616766760608, "White blood cell count decreased ": 3.8952560166661834} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/60.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/60.json new file mode 100644 index 00000000000..58121c607a9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/60.json @@ -0,0 +1 @@ +{"Completed suicide ": 153.44599510511185, "Toxicity to various agents ": 84.87282914211947} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/600.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/600.json new file mode 100644 index 00000000000..b87382a17fa --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/600.json @@ -0,0 +1 @@ +{"Back pain ": 2.302881684585676, "Chronic fatigue syndrome ": 55.21397282854985, "Erythema ": 2.746536531545758, "Hypoaesthesia ": 3.163511475907124, "Migraine ": 3.260808789662923} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/601.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/601.json new file mode 100644 index 00000000000..432160685e7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/601.json @@ -0,0 +1 @@ +{"Actinic keratosis ": 16.530742891415514, "Acute coronary syndrome ": 2.21174276184592, "Acute graft versus host disease ": 2.976029861665217, "Acute graft versus host disease in skin ": 10.98061870651816, "Acute leukaemia ": 31.334361788677946, "Acute lymphocytic leukaemia ": 4.3067977696433815, "Acute myeloid leukaemia ": 29.87365126298891, "Acute myeloid leukaemia recurrent ": 5.066241965662304, "Acute respiratory distress syndrome ": 2.0858421150996, "Adenocarcinoma ": 6.82629803147627, "Alanine aminotransferase abnormal ": 4.0961994334941085, "Alveolar proteinosis ": 60.10570643809699, "Anaemia ": 9.681513657734769, "Ascites ": 4.266644126197976, "Aspergillus infection ": 4.388622574400241, "Atypical mycobacterial infection ": 13.563233624924422, "Autoimmune haemolytic anaemia ": 3.059429832041717, "B-cell lymphoma ": 4.580203866820011, "BK virus infection ": 4.5330797831799, "Bacteraemia ": 4.077083447590366, "Basal cell carcinoma ": 14.183000514784224, "Basophil count increased ": 47.13475456926137, "Blast cell count increased ": 170.59371217443262, "Blast cell crisis ": 59.608178156650254, "Blast cells present ": 77.27963742127534, "Blood bilirubin abnormal ": 9.85098635497116, "Blood bilirubin increased ": 2.0635651738702587, "Blood creatinine abnormal ": 5.264979656927025, "Blood disorder ": 2.4033965640844133, "Blood fibrinogen decreased ": 8.740466280210347, "Blood lactate dehydrogenase increased ": 12.78110612761754, "Blood potassium increased ": 4.469456395365851, "Blood test abnormal ": 2.0883559371075444, "Blood uric acid increased ": 2.064666973283669, "Bone marrow disorder ": 4.94991667788169, "Bone marrow failure ": 3.019366158226479, "Bone marrow oedema ": 9.922623982136145, "Bone pain ": 2.4742777383158425, "Bowen's disease ": 62.51719957612444, "Bronchopulmonary aspergillosis ": 3.0768655645493865, "COVID-19 pneumonia ": 2.029987564586436, "Cachexia ": 4.0974163910647965, "Cardiac failure ": 3.2418268280113054, "Cardiac tamponade ": 6.202155371558426, "Cerebral atrophy ": 2.94734330389285, "Chronic graft versus host disease ": 7.726530333577084, "Chronic lymphocytic leukaemia ": 4.375597144978277, "Chronic myeloid leukaemia ": 7.045606775168763, "Concomitant disease aggravated ": 18.30817143073069, "Concomitant disease progression ": 4.968820546045316, "Coronavirus infection ": 7.737447925725832, "Creatinine renal clearance decreased ": 2.864971886958477, "Cystitis haemorrhagic ": 2.962974964257364, "Cytokine storm ": 25.907490161652994, "Cytomegalovirus infection ": 4.120587164646631, "Cytomegalovirus infection reactivation ": 3.0957088155735946, "Cytopenia ": 12.707895161227489, "Death ": 3.006689032703474, "Diffuse large B-cell lymphoma ": 10.12808825827324, "Diffuse large B-cell lymphoma stage IV ": 67.64561622615646, "Disseminated tuberculosis ": 15.509153222710976, "Dysphagia ": 2.1876368523414564, "Early satiety ": 29.29694100482786, "Embolism ": 2.1243556744546503, "Epstein-Barr virus infection ": 7.063563575731819, "Epstein-Barr virus infection reactivation ": 4.17953228095932, "Erysipelas ": 3.112637977200909, "Escherichia sepsis ": 7.086565715302659, "Escherichia urinary tract infection ": 4.222483264128046, "Extramedullary haemopoiesis ": 67.64561622615646, "Fasciitis ": 43.13085105785789, "Fibrosis ": 6.99209824927695, "Full blood count abnormal ": 4.174938442858459, "Full blood count decreased ": 6.866002485008272, "Gamma-glutamyltransferase increased ": 2.019812523132024, "Gastric ulcer ": 2.672390243200144, "Gastric varices haemorrhage ": 26.32532128778129, "Gastrointestinal haemorrhage ": 2.3123365036343437, "General physical condition abnormal ": 6.987425868536882, "General physical health deterioration ": 3.1788712304789164, "Glomerular filtration rate decreased ": 2.7396190427469653, "Graft versus host disease ": 8.90029176339465, "Graft versus host disease in gastrointestinal tract ": 4.947700989967922, "Graft versus host disease in skin ": 6.3151857302981576, "Haematocrit abnormal ": 17.441802451416223, "Haematocrit decreased ": 10.46136745343274, "Haematocrit increased ": 25.10358107547944, "Haematoma ": 2.664438045667437, "Haematoma muscle ": 2.372715717867313, "Haematotoxicity ": 3.142326186994431, "Haemoglobin abnormal ": 13.860381055857294, "Haemoglobin decreased ": 15.274251938544262, "Haemoglobin increased ": 10.489563991646015, "Haemolysis ": 4.443354402810808, "Haemorrhage ": 2.421802344151949, "Haemorrhage subcutaneous ": 2.1028278670910727, "Haemorrhagic diathesis ": 2.2439453542282384, "Haemosiderosis ": 88.3270206100171, "Haptoglobin decreased ": 9.252306126008834, "Hepatitis B reactivation ": 9.476876568668152, "Hepatomegaly ": 6.644585489172268, "Hepatosplenomegaly ": 11.063642454228606, "Hepatotoxicity ": 2.061009489696677, "Herpes virus infection ": 4.387887526162106, "Herpes zoster ": 3.777462339358639, "Hyperkeratosis ": 2.0543411131699485, "Hypertriglyceridaemia ": 3.6152049458251634, "Hyperuricaemia ": 3.1074759607783338, "Hypogammaglobulinaemia ": 3.3704318110371605, "Immunosuppression ": 7.457681043790479, "Inappropriate schedule of product administration ": 2.3987360299331915, "Increased appetite ": 2.3640481543499825, "Infection ": 3.688428738706252, "Iron deficiency ": 2.704818773691545, "Iron overload ": 21.958596629761185, "Kaposi's sarcoma ": 7.694048429168653, "Laboratory test abnormal ": 2.139621419482668, "Leukaemia ": 14.991140403365906, "Leukocytosis ": 11.868743467460938, "Liver abscess ": 4.380022929058129, "Lung neoplasm malignant ": 2.003483681007594, "Lymph node tuberculosis ": 60.97275278868206, "Lymphocyte count decreased ": 4.880386646944058, "Lymphocyte count increased ": 5.885034663283319, "Lymphocytosis ": 6.907672565156201, "Lymphoma ": 3.2886400772214004, "Lymphopenia ": 3.1371209291842708, "Mean cell haemoglobin concentration decreased ": 17.361117034449848, "Mean cell volume decreased ": 14.910970826041302, "Mean cell volume increased ": 13.54089698954817, "Metastases to liver ": 2.0871034853812107, "Metastases to lymph nodes ": 2.305338622748669, "Monocyte count increased ": 4.315617139061603, "Multiple organ dysfunction syndrome ": 2.6163643856469765, "Mycobacterial infection ": 9.09226126479271, "Mycobacterium avium complex infection ": 5.453006197334908, "Myelodysplastic syndrome ": 2.025101666666671, "Myelofibrosis ": 325.718443353204, "Myeloproliferative neoplasm ": 38.99379197621237, "Myositis ": 2.750650369892375, "Necrosis ": 2.7559405163344635, "Neoplasm ": 2.4786002298590435, "Neoplasm skin ": 15.647972769752108, "Neuroendocrine carcinoma of the skin ": 82.92425922340112, "Neutrophil count increased ": 9.5737738024387, "Neutrophil percentage increased ": 11.604024378258543, "Night sweats ": 3.353171352384323, "Oesophageal varices haemorrhage ": 14.852709006818234, "Pancytopenia ": 3.879487509835128, "Platelet count abnormal ": 15.920147433236416, "Platelet count decreased ": 13.068735410011875, "Platelet count increased ": 55.85902523398672, "Platelet disorder ": 7.057734453232928, "Pleural effusion ": 2.266021602565759, "Pneumocystis jirovecii pneumonia ": 5.176793968060559, "Pneumonia ": 2.667213719591924, "Pneumonia fungal ": 3.0143728405718435, "Pneumonitis ": 2.0949123610883578, "Polycythaemia vera ": 152.31551694094267, "Portal hypertension ": 5.502912316308954, "Portal vein thrombosis ": 7.406106254026403, "Post herpetic neuralgia ": 2.260889048951999, "Post procedural haemorrhage ": 4.508040879506992, "Primary myelofibrosis ": 400.4249844935871, "Product supply issue ": 9.658523351269674, "Product use in unapproved indication ": 5.162095336110975, "Progressive multifocal leukoencephalopathy ": 4.5239408838045065, "Pulmonary alveolar haemorrhage ": 2.9836123145226505, "Pulmonary arterial hypertension ": 2.562257135838523, "Pulmonary hypertension ": 5.022630295535064, "Pulmonary mass ": 2.019512198295076, "Pulmonary tuberculosis ": 9.14120829862694, "Pyoderma gangrenosum ": 6.272194798499495, "Rectal cancer ": 4.412952134802672, "Red blood cell count decreased ": 6.557492891615762, "Red blood cell count increased ": 21.947840768986847, "Red cell distribution width increased ": 15.073945535628592, "Respiratory failure ": 2.059714649352986, "Respiratory tract infection ": 4.0705877568871625, "Reticulocyte count increased ": 14.129701593787344, "Second primary malignancy ": 75.7229662116623, "Sepsis ": 3.555975252120705, "Septic shock ": 3.595787377626628, "Serum ferritin increased ": 6.740696760701432, "Skin cancer ": 13.001622865158804, "Skin haemorrhage ": 2.961791512905184, "Skin lesion ": 2.501804836405108, "Skin papilloma ": 4.192325546590464, "Skin ulcer ": 2.114616105004522, "Spleen disorder ": 82.31056767861236, "Splenic infarction ": 22.64741060738836, "Splenic rupture ": 48.17878116022661, "Splenomegaly ": 98.30616730863356, "Squamous cell carcinoma ": 38.301935310868586, "Squamous cell carcinoma of skin ": 30.801730150549943, "Subdural haematoma ": 2.194840061450238, "Sudden death ": 2.0800205949835164, "Terminal state ": 3.481818508214796, "Therapeutic response decreased ": 2.9197190582334964, "Therapy non-responder ": 3.9520866026226575, "Thrombocytopenia ": 8.64868345351827, "Thrombocytosis ": 29.978813834095117, "Thrombotic microangiopathy ": 2.0533983118261814, "Transaminases increased ": 2.22614234615017, "Transformation to acute myeloid leukaemia ": 418.244021212654, "Tuberculosis ": 20.16586588925764, "Tumour lysis syndrome ": 2.997671488307312, "Ulcer ": 3.670730654767126, "Urinary tract infection ": 2.256711457619597, "Varices oesophageal ": 11.494522491983023, "Weight increased ": 3.74843211125026, "White blood cell count abnormal ": 4.445374356989444, "White blood cell count decreased ": 2.4896111222027724, "White blood cell count increased ": 21.374728181539915, "White blood cell disorder ": 9.01802196483206, "Withdrawal syndrome ": 2.076852313926953} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/602.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/602.json new file mode 100644 index 00000000000..783f068a369 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/602.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 6.532704798762095, "Abdominal hernia ": 4.246133578101267, "Abdominal lymphadenopathy ": 10.352645198801184, "Abnormal loss of weight ": 7.07743946226606, "Abscess drainage ": 16.12936836817677, "Accident ": 4.077428397369374, "Acute kidney injury ": 2.3703684490191037, "Adenocarcinoma pancreas ": 118.27019031322354, "Adrenal adenoma ": 40.57961119185602, "Adrenal disorder ": 7.760835061608442, "Adrenal mass ": 51.4486755151742, "Adverse event ": 7.3105707338232895, "Amylase increased ": 8.181117647102, "Anaemia of chronic disease ": 20.214009215199265, "Aneurysm ": 2.529347612870501, "Angioplasty ": 11.778053954653188, "Ankle operation ": 17.871831434914583, "Anuria ": 2.3122994608737164, "Aortic aneurysm ": 4.494329680254895, "Aortic arteriosclerosis ": 29.015161014734176, "Appendicectomy ": 19.56527879529214, "Arterial disorder ": 17.337857514953527, "Arterial occlusive disease ": 3.056142171303218, "Arteriosclerosis ": 5.585314612301204, "Arteriosclerosis coronary artery ": 6.8364671189082085, "Arthroscopy ": 18.614370943470064, "Ascites ": 2.008981467513166, "Atelectasis ": 14.223958260351814, "Barrett's oesophagus ": 4.858320255899075, "Benign prostatic hyperplasia ": 13.331830678936385, "Bicytopenia ": 3.87294134869196, "Bile duct stenosis ": 31.078639217729645, "Bile duct stent insertion ": 121.48265306869853, "Bile duct stone ": 7.967569967013531, "Biliary dilatation ": 22.496983126525677, "Biliary obstruction ": 27.954482521871714, "Biopsy liver ": 45.94811212194794, "Blood cholesterol abnormal ": 7.850364523430417, "Blood cholesterol increased ": 2.794108429038909, "Blood creatinine abnormal ": 2.974079607251851, "Blood glucose abnormal ": 12.312648526595048, "Blood glucose decreased ": 3.414958301115501, "Blood glucose fluctuation ": 5.73702176649127, "Blood glucose increased ": 5.608937464255798, "Blood lactic acid ": 52.03162005849007, "Blood lactic acid increased ": 2.064413452794065, "Blood magnesium decreased ": 3.2423120843359223, "Blood triglycerides abnormal ": 13.024026602744229, "Blood triglycerides increased ": 3.774069154477545, "Bone lesion ": 3.964075991786188, "Bundle branch block right ": 2.052687411509297, "Calculus bladder ": 11.370737071065593, "Cardiac murmur ": 3.349674733504921, "Cardiac operation ": 6.27055568912444, "Cardiac pacemaker insertion ": 3.721502944049016, "Cardiomegaly ": 2.7831680377747445, "Carpal tunnel decompression ": 21.718846123530312, "Cataract operation ": 11.27158413215527, "Catheter placement ": 6.177573232899661, "Catheterisation cardiac ": 3.061587782552317, "Central venous catheterisation ": 6.006132464685732, "Cerebrovascular accident ": 2.4021105954716453, "Chemotherapy ": 7.72397513842111, "Cholangiocarcinoma ": 8.909702863446293, "Cholangitis ": 7.839497423433308, "Cholecystectomy ": 30.071097306961622, "Cholecystitis ": 5.362700387844019, "Cholecystitis chronic ": 24.61986531921088, "Cholelithiasis ": 12.19815211755869, "Chronic gastritis ": 8.126706467526548, "Circumstance or information capable of leading to medication error ": 10.141646726906476, "Colorectal adenoma ": 10.51235184839325, "Constipation ": 3.062135154922481, "Coronary angioplasty ": 6.778043084729179, "Coronary arterial stent insertion ": 7.868938740092327, "Coronary artery bypass ": 4.457058950477769, "Coronary artery disease ": 3.2301725551153213, "Counterfeit product administered ": 9.336665682361522, "Death ": 2.132988091991107, "Decubitus ulcer ": 6.142129817724489, "Dementia ": 2.130302524146682, "Dementia Alzheimer's type ": 2.200807864547316, "Device occlusion ": 3.158311766301718, "Diabetes mellitus ": 2.9373070610461123, "Diabetes mellitus inadequate control ": 22.949770282321506, "Diabetic complication ": 49.57003998749576, "Diabetic metabolic decompensation ": 13.372696042377507, "Diabetic nephropathy ": 11.182808821009957, "Diabetic neuropathy ": 19.49834522090172, "Diabetic retinopathy ": 2.791674732385608, "Disease complication ": 8.313340450689847, "Diverticulum ": 10.427998186122958, "Diverticulum intestinal ": 18.433687217587597, "Ductal adenocarcinoma of pancreas ": 70.28352840302249, "Duodenitis ": 3.3936206974807925, "Dyslipidaemia ": 3.605746382689284, "Dysphagia ": 6.257790160595537, "Dyspnoea at rest ": 4.1818935395969, "Emphysema ": 5.181486564444433, "Epigastric discomfort ": 2.1303969319188383, "Erectile dysfunction ": 2.7958751879965567, "Escherichia test positive ": 12.41131437835183, "Essential hypertension ": 15.538557868968844, "Eye operation ": 8.146558387597219, "Faecaloma ": 3.5741059461158784, "Failure to thrive ": 6.882051143515353, "Flatulence ": 2.4907596193313366, "Flour sensitivity ": 851.6940466569175, "Functional gastrointestinal disorder ": 2.341530866193384, "Gallbladder disorder ": 6.891627969314778, "Gallbladder enlargement ": 9.24346013856321, "Gallbladder operation ": 6.848911325784205, "Gastric ulcer ": 2.8011254259936016, "Gastric varices ": 22.944068092231003, "Gastritis ": 3.29039949417512, "Gastrointestinal disorder ": 2.757949605982369, "Gastrointestinal sounds abnormal ": 2.7459735770343414, "Gastrointestinal tube insertion ": 11.820283505952494, "Gastrointestinal wall thickening ": 16.068027751184317, "Gastrooesophageal reflux disease ": 5.887072291471896, "Gastrostomy ": 11.85000713548491, "Glaucoma ": 2.5399464586071274, "Glycosylated haemoglobin abnormal ": 24.983585131862306, "Glycosylated haemoglobin increased ": 5.542291628235651, "Goitre ": 3.2624858475316123, "Gout ": 3.858619869995816, "Granuloma ": 2.6033921909001174, "Haemangioma of bone ": 65.89959829726607, "Haemangioma of liver ": 12.137489227834823, "Haemoglobin increased ": 2.546846544237235, "Haemorrhoids ": 3.0484671735528712, "Helicobacter infection ": 2.155701288818075, "Hepatic cancer ": 2.089256003013672, "Hepatic cirrhosis ": 4.982316660693261, "Hepatic cyst ": 17.3324503987451, "Hepatic lesion ": 13.960536625289276, "Hepatic mass ": 4.922105956492443, "Hepatic steatosis ": 8.214726459942288, "Hepatitis acute ": 4.259912244242738, "Hepatomegaly ": 2.8402357754677285, "Hernia repair ": 14.619166618607922, "Hiatus hernia ": 6.072594581658309, "Hydronephrosis ": 2.8036604697081464, "Hyperchlorhydria ": 9.334841391426938, "Hypercholesterolaemia ": 6.74046109121503, "Hyperglycaemia ": 3.113214803658157, "Hyperkalaemia ": 2.207212455315605, "Hyperlactacidaemia ": 4.913308736228389, "Hyperlipidaemia ": 15.579623058804511, "Hypertension ": 2.066679366161157, "Hypoglycaemia ": 3.826717663323439, "Hypoglycaemic coma ": 2.089239798404699, "Hypomagnesaemia ": 3.160496023094699, "Hypovolaemia ": 2.607602963249857, "Hysterectomy ": 21.341633079720545, "Impaired gastric emptying ": 3.1634697441285624, "Inability to afford medication ": 8.276422176835913, "Inappropriate schedule of product administration ": 13.118898365690043, "Incorrect dose administered ": 4.012508839937042, "Inguinal hernia ": 8.934001137597342, "Insulin-requiring type 2 diabetes mellitus ": 60.31980507685837, "Intervertebral disc degeneration ": 3.022681062167986, "Intestinal metastasis ": 20.113043053081725, "Intestinal resection ": 7.432977143356597, "Intra-abdominal fluid collection ": 8.98328689544327, "Iron deficiency anaemia ": 4.587561763338549, "Jaundice cholestatic ": 2.251806406996531, "Knee operation ": 6.229673959581141, "Lactic acidosis ": 13.0537400613629, "Laparotomy ": 11.899209316879938, "Large intestinal polypectomy ": 45.908988500441744, "Large intestine polyp ": 8.457163747183063, "Left ventricular hypertrophy ": 2.7647809072996967, "Leukocytosis ": 2.988494567055332, "Lipase increased ": 17.04002262383921, "Lipoma ": 5.198422199596653, "Lumbar spinal stenosis ": 4.260525870162717, "Lung diffusion test decreased ": 29.43764126396596, "Lung opacity ": 4.107719595571671, "Lymphoma ": 2.301565927996368, "Malignant ascites ": 28.83186335285856, "Malignant neoplasm of ampulla of Vater ": 64.55445316299304, "Malnutrition ": 3.807384667278464, "Mastectomy ": 14.566003265736038, "Metabolic acidosis ": 4.441319586252592, "Metabolic disorder ": 2.137132623247167, "Metastases to abdominal cavity ": 18.26661707233712, "Metastases to adrenals ": 8.672430433070476, "Metastases to bone ": 2.1760633339579263, "Metastases to liver ": 19.86722797455172, "Metastases to lung ": 6.289501541293526, "Metastases to lymph nodes ": 16.911174490180073, "Metastases to peritoneum ": 32.591093776001884, "Metastases to spleen ": 41.19274318393758, "Metastasis ": 4.677292685727501, "Metastatic neoplasm ": 5.386877084256314, "Microalbuminuria ": 7.622660228825891, "Multiple allergies ": 3.9167183064023208, "Myocardial infarction ": 2.915181230998567, "Nephrolithiasis ": 5.330073768713016, "Neutrophilia ": 5.306298111242307, "Obstructive sleep apnoea syndrome ": 7.483540892896189, "Osteoarthritis ": 4.729625013115848, "Pancreatectomy ": 103.41019534321238, "Pancreatic carcinoma ": 51.440316858249815, "Pancreatic carcinoma metastatic ": 110.41004211417928, "Pancreatic carcinoma stage IV ": 48.44641928719288, "Pancreatic cyst ": 25.0953126842088, "Pancreatic disorder ": 5.690017729910943, "Pancreatic duct dilatation ": 71.3415470343592, "Pancreatic enzymes increased ": 9.064673798950643, "Pancreatic failure ": 6.701352793843782, "Pancreatic mass ": 23.845881555043864, "Pancreatic neoplasm ": 21.921872454985728, "Pancreatic neuroendocrine tumour ": 8.786327447522655, "Pancreatic pseudocyst ": 18.227238062616014, "Pancreatic stent placement ": 191.14148497573888, "Pancreaticoduodenectomy ": 170.10795683074954, "Pancreatitis ": 27.626295296434662, "Pancreatitis acute ": 17.099378456043898, "Pancreatitis chronic ": 34.558062817423206, "Pancreatitis necrotising ": 9.83296340018686, "Pemphigoid ": 6.37902902093416, "Peripheral arterial occlusive disease ": 2.347033230075813, "Pneumobilia ": 171.5832851999647, "Pneumonia klebsiella ": 7.136981755749122, "Polydipsia ": 3.5572962546358764, "Prescription drug used without a prescription ": 3.329489056769431, "Product availability issue ": 2.6374662888767424, "Product colour issue ": 5.026377358849203, "Product dispensing error ": 2.4208658886875427, "Product prescribing issue ": 5.861640684954498, "Product size issue ": 8.240783413111822, "Product taste abnormal ": 2.124366227912344, "Product use complaint ": 5.592577244810446, "Prostatitis ": 5.078699765440058, "Prostatomegaly ": 19.20455142904344, "Pulmonary granuloma ": 11.62897203542033, "Pulmonary mass ": 8.060156554004632, "Pulse abnormal ": 2.40640090005485, "Radiotherapy ": 29.39791720144687, "Regurgitation ": 3.118893004302316, "Renal cyst ": 18.660443414514063, "Renal disorder ": 2.9591753498991547, "Respiratory symptom ": 4.0501868784724815, "Rotator cuff repair ": 12.671764333352703, "Small intestinal obstruction ": 4.288615975899599, "Spinal operation ": 6.773576666071012, "Spinal osteoarthritis ": 10.247926472208215, "Splenectomy ": 38.50342442471683, "Splenic vein occlusion ": 148.60633613935835, "Splenic vein thrombosis ": 36.03663228986306, "Stent placement ": 4.660968495449603, "Surgery ": 4.001932360641263, "Suspected counterfeit product ": 5.342209508776272, "Thyroid cancer ": 5.522385934452648, "Thyroid mass ": 2.8285726511150115, "Thyroid operation ": 29.294801343146897, "Thyroidectomy ": 12.683965879919292, "Toe amputation ": 4.371103465973167, "Tonsillectomy ": 15.16844149877871, "Tumour invasion ": 72.69131295059448, "Type 2 diabetes mellitus ": 2.1289501421652712, "Umbilical hernia ": 8.967303554201997, "Uterine leiomyoma ": 2.486831060181707, "Varices oesophageal ": 4.941632104652662, "Vascular graft ": 6.453306694806062, "Vitamin B12 decreased ": 5.420318170587345, "Weight decreased ": 2.380902698971627, "Weight fluctuation ": 2.751495841908179, "Wrong technique in product usage process ": 6.167337163403306} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/603.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/603.json new file mode 100644 index 00000000000..be83339b301 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/603.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 5.411829508548316, "Abdominal hernia ": 9.111805541926955, "Abdominal pain upper ": 2.0059930625830398, "Abdominal rigidity ": 4.007638307492361, "Abnormal loss of weight ": 3.907935796149604, "Acute kidney injury ": 2.410840691464608, "Adenocarcinoma pancreas ": 87.15553218523193, "Adrenal mass ": 31.49953015406459, "Adverse event ": 9.481294967558572, "Amylase increased ": 9.30897824846138, "Anaemia of chronic disease ": 39.20223787633837, "Angioplasty ": 7.077460816221555, "Anxiety disorder ": 2.6078026570130275, "Aortic aneurysm ": 6.340050655965332, "Aortic arteriosclerosis ": 36.81995971072208, "Appendicectomy ": 22.048758276953723, "Appendix disorder ": 20.47425259671117, "Arteriosclerosis ": 4.084677463673096, "Arteriosclerosis coronary artery ": 7.126013386007306, "Ascites ": 2.9548622956717066, "Atelectasis ": 11.915110828589231, "Atrioventricular block first degree ": 2.5940617338730334, "Barrett's oesophagus ": 3.899518240351196, "Benign prostatic hyperplasia ": 11.983323802685156, "Bile duct cancer ": 9.089296311098654, "Bile duct stenosis ": 45.911639727923706, "Bile duct stent insertion ": 207.5945946224801, "Bile duct stone ": 10.065711819156355, "Biliary dilatation ": 28.948313782289134, "Biliary obstruction ": 18.785304554755182, "Biliary tract disorder ": 10.085625649255206, "Biopsy liver ": 38.42672633533208, "Biopsy pancreas ": 230.84991083060143, "Bladder disorder ": 6.997635377179516, "Blood cholesterol abnormal ": 3.6104248793646816, "Blood glucose abnormal ": 7.728435781967854, "Blood glucose decreased ": 3.6641696805155335, "Blood glucose fluctuation ": 3.8786111760741258, "Blood glucose increased ": 4.498967441447852, "Blood loss anaemia ": 2.7426803045975863, "Blood potassium increased ": 2.031461032161722, "Blood pressure diastolic abnormal ": 6.157339770223707, "Blood pressure diastolic decreased ": 3.739223912193413, "Blood pressure systolic decreased ": 3.072645256243865, "Blood triglycerides increased ": 2.253327068895556, "Brain natriuretic peptide increased ": 3.127585634251673, "Cachexia ": 3.513754608801292, "Cardiac murmur ": 3.010871062150327, "Cardiac operation ": 3.0833737713961327, "Cardiac pacemaker insertion ": 6.972863985995172, "Cardiomegaly ": 2.2170918546334955, "Cardiovascular insufficiency ": 2.7951852559606523, "Carpal tunnel decompression ": 43.69653346331915, "Cataract ": 2.010877773722391, "Cataract operation ": 8.527728452256126, "Catheter placement ": 8.292377821636826, "Central venous catheterisation ": 5.937037726718078, "Cerebrovascular accident ": 2.068911264369683, "Cholangiocarcinoma ": 9.627784652677205, "Cholangitis ": 6.2382858210847045, "Cholecystectomy ": 19.566339869656584, "Cholecystitis ": 3.917782039632061, "Cholecystitis acute ": 2.938001639445291, "Cholecystitis chronic ": 14.426656911212511, "Cholelithiasis ": 10.612519155420008, "Chronic gastritis ": 5.026518104156921, "Chronic obstructive pulmonary disease ": 3.046042114918674, "Circumstance or information capable of leading to medication error ": 6.323790004703636, "Colectomy ": 9.436159042095078, "Colon cancer ": 2.961843118982559, "Colonoscopy ": 10.525422215393371, "Colorectal adenoma ": 6.694468535768031, "Complication associated with device ": 2.7312366393826726, "Constipation ": 3.25792348447324, "Coronary arterial stent insertion ": 7.073050111959407, "Coronary artery bypass ": 6.714038317963123, "Coronary artery disease ": 4.39884907423497, "Death ": 2.008295659075653, "Decubitus ulcer ": 3.0408725616524674, "Dehydration ": 2.44342497821472, "Dementia ": 2.2594358235708087, "Dermatitis bullous ": 2.0711471658524383, "Dermatitis exfoliative ": 3.1637372916046536, "Device occlusion ": 3.321174009284645, "Diabetes mellitus ": 3.305050453022337, "Diabetes mellitus inadequate control ": 19.180688467661472, "Diabetic complication ": 40.179247410170674, "Diabetic nephropathy ": 8.874988575258415, "Diabetic neuropathy ": 10.098974786103687, "Diabetic retinopathy ": 7.688628401269162, "Dialysis ": 5.127136322397493, "Diastolic dysfunction ": 3.791467854441077, "Disability assessment scale score increased ": 47.95484363882093, "Disease complication ": 4.790645945058527, "Diverticulum ": 8.774352220282179, "Diverticulum intestinal ": 11.855539869561465, "Ductal adenocarcinoma of pancreas ": 102.99031407032784, "Duodenal ulcer ": 3.7594226531965895, "Duodenitis ": 2.692060788775488, "Dyslipidaemia ": 4.769396955951773, "Dysphagia ": 3.409930239771515, "Emphysema ": 2.226606735218453, "Eosinophil count increased ": 2.296252776057526, "Essential hypertension ": 9.112397556056871, "Failure to thrive ": 3.8423422431972822, "Flatulence ": 2.048451849466444, "Fungal test positive ": 17.777012565447045, "Gallbladder disorder ": 6.886045928748315, "Gallbladder enlargement ": 9.142924728060771, "Gallbladder operation ": 7.394897326739481, "Gastric ulcer ": 2.668344078212165, "Gastritis ": 2.674295690074475, "Gastroenterostomy ": 156.3101028095204, "Gastrointestinal tube insertion ": 14.237684525825111, "Gastrooesophageal reflux disease ": 4.193857916288003, "Gastrostomy ": 13.692366248616723, "Gingivitis ": 2.160676047524135, "Glaucoma ": 3.5678032952166734, "Glycosylated haemoglobin abnormal ": 15.958974386412882, "Glycosylated haemoglobin decreased ": 15.163698231122646, "Glycosylated haemoglobin increased ": 6.906844466064206, "Goitre ": 2.034800700527514, "Gout ": 3.208445921147673, "Haemangioma of liver ": 10.909889206594755, "Haemorrhoid operation ": 55.17256324537502, "Haemorrhoids ": 2.105559600716193, "Hepatic cirrhosis ": 2.62291633798551, "Hepatic cyst ": 11.927521072229212, "Hepatic lesion ": 9.830982992202497, "Hepatic mass ": 10.065711819156355, "Hepatic steatosis ": 5.413213356394599, "Hernia repair ": 10.707654272441452, "Hiatus hernia ": 6.082942835515455, "Hunger ": 3.573810191574963, "Hypercholesterolaemia ": 5.513922783639032, "Hyperlipasaemia ": 16.563816658372744, "Hyperlipidaemia ": 11.766845045807733, "Hypertensive heart disease ": 5.2133195902605936, "Hypertriglyceridaemia ": 2.11199929218251, "Hypoglycaemia ": 7.818833163262205, "Hypoglycaemic coma ": 7.876784529663348, "Hypoglycaemic encephalopathy ": 18.55567434269789, "Hyporeflexia ": 3.015272438536037, "Hypovolaemia ": 3.4722612878907597, "Hysterectomy ": 16.49436088771977, "Ileus ": 4.968120112268087, "Impaired gastric emptying ": 3.028640280251992, "Inability to afford medication ": 13.834756738896036, "Increased tendency to bruise ": 2.21863202571045, "Inguinal hernia ": 5.109310757510031, "Insulin-requiring type 2 diabetes mellitus ": 66.15063661684395, "Insurance issue ": 3.355479327212588, "Interstitial lung disease ": 3.407923210034577, "Intervertebral disc degeneration ": 2.559528055596142, "Intestinal obstruction ": 3.330267841869171, "Iron deficiency anaemia ": 2.7318980392954737, "Jaundice cholestatic ": 4.142499603626009, "Ketoacidosis ": 2.084633540938085, "Knee arthroplasty ": 2.722173967592781, "Knee operation ": 5.599579872559818, "Lactic acidosis ": 2.829537625628609, "Laparotomy ": 26.279891388220648, "Large intestine polyp ": 4.495401065837074, "Leukocytosis ": 3.26894626282866, "Lipase abnormal ": 28.96956336952664, "Lipase increased ": 17.048021654068837, "Lipoma ": 5.697905834059018, "Lower respiratory tract congestion ": 13.978001519025815, "Malignant peritoneal neoplasm ": 17.584144466350097, "Malnutrition ": 6.5371979951144406, "Mammoplasty ": 32.371633368699, "Mastectomy ": 12.177316021787306, "Metastases to adrenals ": 13.121399701689672, "Metastases to bone ": 2.559705449641625, "Metastases to liver ": 17.51079759940971, "Metastases to lung ": 7.623409756973144, "Metastases to lymph nodes ": 13.19697488441654, "Metastases to peritoneum ": 12.638973958185373, "Metastases to spleen ": 14.738469939243368, "Metastasis ": 3.160345485280885, "Metastatic neoplasm ": 4.842037036549811, "Muscle tightness ": 2.252211803410609, "Neoplasm malignant ": 2.282813123309375, "Nephrolithiasis ": 4.021054637924353, "Normochromic normocytic anaemia ": 3.553495622279256, "Normocytic anaemia ": 3.7727303207559895, "Obstruction gastric ": 11.244190319169984, "Obstructive pancreatitis ": 12.98287556480673, "Obstructive sleep apnoea syndrome ": 6.104547756404069, "Oedematous pancreatitis ": 15.763101205581638, "Osteoarthritis ": 3.746527455364527, "Pancreatectomy ": 99.443323290227, "Pancreatic carcinoma ": 65.45542945970087, "Pancreatic carcinoma metastatic ": 93.2899845189841, "Pancreatic carcinoma stage IV ": 26.179956446116638, "Pancreatic cyst ": 25.0127214099448, "Pancreatic disorder ": 7.704838901039387, "Pancreatic duct dilatation ": 21.877513668252533, "Pancreatic enzymes increased ": 8.147849380561984, "Pancreatic mass ": 31.445443621359328, "Pancreatic neoplasm ": 11.325499520086856, "Pancreatic neuroendocrine tumour ": 7.117943810599132, "Pancreatic pseudocyst ": 11.084099614188649, "Pancreatic stent placement ": 101.2944267596451, "Pancreaticoduodenectomy ": 242.48014885587503, "Pancreatitis ": 36.443906758260574, "Pancreatitis acute ": 24.847722364374416, "Pancreatitis chronic ": 33.63753706259275, "Pancreatitis necrotising ": 18.4426117276304, "Pancreatitis relapsing ": 8.513367501894463, "Pancreatobiliary sphincterotomy ": 251.8054739786547, "Pemphigoid ": 39.925947295972136, "Peripheral vascular disorder ": 2.458773352660824, "Pneumobilia ": 67.64771204508088, "Polyp ": 3.0067486120070237, "Portal vein thrombosis ": 2.159127344941448, "Post procedural complication ": 2.063094705788182, "Product packaging quantity issue ": 7.323581151586458, "Product prescribing issue ": 2.526348914057953, "Product residue present ": 2.167479693854709, "Prostatomegaly ": 15.006842997796722, "Pulmonary mass ": 6.848373101185476, "Radiotherapy ": 30.19286576594793, "Renal cyst ": 16.592072601003256, "Renal disorder ": 2.030781637757403, "Renal mass ": 4.9056993141748535, "Rhabdomyolysis ": 2.0986702847123646, "Seronegative arthritis ": 34.66076063786128, "Sinus congestion ": 4.322411377141879, "Soft tissue injury ": 23.419770355256897, "Spinal operation ": 3.270677319000443, "Spinal osteoarthritis ": 8.610673112766573, "Splenectomy ": 24.422277086002293, "Splenic vein thrombosis ": 13.084852943744393, "Stent placement ": 8.122769349342567, "Surgery ": 3.776308005941461, "Throat cancer ": 3.5396585189141927, "Thyroid mass ": 4.105133675601592, "Toe amputation ": 3.50881997514175, "Tonsillectomy ": 40.74743326665609, "Type 2 diabetes mellitus ": 2.431855441583918, "Umbilical hernia ": 6.656263467274217, "Uterine leiomyoma ": 2.2353113238085918, "Vitamin B12 decreased ": 5.524205912729828, "Weight fluctuation ": 5.880919100784312, "Wrong technique in product usage process ": 4.329146970490279} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/604.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/604.json new file mode 100644 index 00000000000..b6191d181ae --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/604.json @@ -0,0 +1 @@ +{"Rash ": 14.513881431935465} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/605.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/605.json new file mode 100644 index 00000000000..12043926704 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/605.json @@ -0,0 +1 @@ +{"Abnormal loss of weight ": 4.801740890471533, "Abscess ": 2.6944837279420786, "Abscess limb ": 4.780448596184982, "Acetonaemia ": 46.39168022478136, "Acidosis ": 11.579596267138612, "Acquired phimosis ": 70.54379367038923, "Acute kidney injury ": 3.0540044915988664, "Acute myocardial infarction ": 2.2614099076707594, "Adrenal insufficiency ": 2.497138464501347, "Altered state of consciousness ": 2.877542979619583, "Amputation ": 18.30594198260108, "Amylase increased ": 2.233571832938553, "Anal abscess ": 11.006052867288464, "Anal pruritus ": 2.769210884809375, "Anion gap ": 33.62096270061436, "Anion gap increased ": 5.178923155646612, "Anxiety disorder ": 4.3876998348601335, "Aortic valve replacement ": 6.087314031052674, "Bacterial test positive ": 3.353447651415428, "Bacteriuria ": 20.053690738585853, "Balanitis candida ": 271.809110623827, "Balanoposthitis ": 500.0130687873869, "Benign prostatic hyperplasia ": 2.6287490580911834, "Bladder cancer ": 3.225131579039912, "Bladder neoplasm ": 7.439349566077374, "Bladder pain ": 6.405618116516284, "Blindness ": 2.200560377425919, "Blood bicarbonate abnormal ": 33.38899182601525, "Blood bicarbonate decreased ": 3.3973972552316525, "Blood creatine increased ": 3.140052707638863, "Blood creatinine decreased ": 2.604213913054723, "Blood glucose abnormal ": 7.688193206084235, "Blood glucose decreased ": 2.371039581134648, "Blood glucose increased ": 3.4299067612660146, "Blood glucose normal ": 34.80169784181882, "Blood insulin decreased ": 30.41091522748447, "Blood ketone body ": 50.45762181837932, "Blood ketone body increased ": 109.44354931515493, "Blood ketone body present ": 29.154674865718928, "Blood pH abnormal ": 90.66832647287978, "Blood pH decreased ": 3.207776266907315, "Blood sodium increased ": 3.662972413178385, "Blood urine present ": 2.126059874790397, "Brain operation ": 4.097554443824843, "Brain stem infarction ": 2.801404525076701, "Breath odour ": 2.700179738509093, "COVID-19 pneumonia ": 2.6289045331425007, "Calculus urinary ": 4.979755256006145, "Candida infection ": 15.833458235358629, "Candida sepsis ": 7.745567236286045, "Cardiac failure ": 3.3275043759935667, "Cardiac operation ": 20.500149801187423, "Cardiac pacemaker insertion ": 3.2558753923421766, "Carotid artery stenosis ": 2.047691992522021, "Catheterisation cardiac ": 4.015816800054126, "Cellulitis of male external genital organ ": 101.29555790672087, "Cerebellar infarction ": 3.143025984803554, "Cerebral infarction ": 2.257530093549448, "Cerebrovascular accident ": 4.093612452643347, "Circumcision ": 106.40946322426382, "Coma acidotic ": 39.398991553231255, "Coronary arterial stent insertion ": 2.735760936899989, "Coronary artery bypass ": 7.473150337126444, "Creatinine renal clearance abnormal ": 28.773943708448492, "Culture urine positive ": 9.687369916474385, "Cystitis ": 10.212584493408531, "Cystitis haemorrhagic ": 2.496940674395949, "Cystitis noninfective ": 4.860290388643475, "Death ": 2.239697479614426, "Debridement ": 18.30986879328162, "Dehydration ": 7.893456052401319, "Dementia ": 4.728857955557423, "Diabetes mellitus inadequate control ": 2.068517325159802, "Diabetic coma ": 5.371521900967745, "Diabetic foot ": 13.556308451523613, "Diabetic foot infection ": 8.244784523169459, "Diabetic ketoacidosis ": 129.53236033856984, "Diabetic ketosis ": 35.219671564422946, "Diabetic metabolic decompensation ": 5.251119259200103, "Diet refusal ": 5.387306326675446, "Disease complication ": 4.560793083191063, "Dry mouth ": 2.362057715539907, "Dysuria ": 12.021156007378602, "Electrolyte imbalance ": 2.0183706471109675, "Emphysematous cystitis ": 58.75033885533983, "Emphysematous pyelonephritis ": 66.83936493014743, "Endotracheal intubation ": 2.088495870063936, "Epididymitis ": 7.486927317012153, "Escherichia infection ": 5.561746740969323, "Escherichia sepsis ": 4.673384982986748, "Escherichia urinary tract infection ": 6.069027123508414, "Euglycaemic diabetic ketoacidosis ": 539.4877288237964, "Extremity necrosis ": 10.071552464857172, "Eye operation ": 2.217988834485067, "Faeces hard ": 3.6322357387733226, "Failure to suspend medication ": 28.143386811326703, "Febrile infection ": 8.271446706783479, "Female reproductive tract disorder ": 30.957818849805463, "Flatulence ": 2.1335215158047047, "Fluid intake reduced ": 5.020399545658953, "Food craving ": 8.881953527636798, "Foot amputation ": 17.529359952492815, "Fournier's gangrene ": 527.484459202583, "Fungal balanitis ": 111.008593410883, "Fungal cystitis ": 95.33047787754155, "Fungal infection ": 37.47873351420503, "Fungal skin infection ": 3.617685638893763, "Gangrene ": 17.595760484441676, "Gastroenteritis ": 5.289713761698752, "Gastrointestinal infection ": 2.809379860524811, "Genital abscess ": 37.36415549023669, "Genital blister ": 35.10771013966773, "Genital burning sensation ": 55.69864914855376, "Genital candidiasis ": 159.89938037319976, "Genital discharge ": 23.075812549401217, "Genital discomfort ": 34.518564593873194, "Genital erythema ": 74.28538473195147, "Genital haemorrhage ": 2.225091119975347, "Genital herpes ": 2.227080194877809, "Genital infection ": 622.6050510271971, "Genital infection female ": 136.11923258133635, "Genital infection fungal ": 571.462430813072, "Genital infection male ": 318.45971060516763, "Genital pain ": 20.411634626234928, "Genital rash ": 23.55505908119773, "Genital swelling ": 36.65258157815828, "Genital tract inflammation ": 152.65840759011948, "Genital ulceration ": 12.781005190717526, "Genitourinary tract infection ": 330.9175402291273, "Glomerular filtration rate abnormal ": 8.889983646381813, "Glomerular filtration rate decreased ": 17.19735007123964, "Glomerular filtration rate increased ": 10.052622838322598, "Glucose urine ": 28.11855533488308, "Glucose urine present ": 45.55519758398425, "Glycosuria ": 25.42934990386668, "Glycosylated haemoglobin ": 26.479544845359836, "Glycosylated haemoglobin abnormal ": 35.01544088471152, "Glycosylated haemoglobin decreased ": 30.20169478597335, "Glycosylated haemoglobin increased ": 12.317116876336312, "Groin abscess ": 12.226608019564498, "Groin infection ": 18.224603545051057, "Haematocrit increased ": 51.86051337387845, "Haematuria ": 2.5647124553755, "Haemoglobin increased ": 12.60911246267694, "Heart valve operation ": 20.005793438378188, "Hunger ": 4.790496585940269, "Hyperglycaemia ": 2.4274590458928684, "Hyperglycaemic hyperosmolar nonketotic syndrome ": 27.519081179378546, "Hypernatraemia ": 8.935954615055323, "Hyperventilation ": 3.034740218011644, "Hypoglycaemia ": 2.4305338327709256, "Hypophagia ": 6.067664753534989, "Hypovolaemia ": 12.50705097525911, "Hypovolaemic shock ": 2.6678334283396348, "Incontinence ": 2.8550284174350056, "Increased appetite ": 2.000831254515014, "Inflammatory marker increased ": 2.244689008308591, "Insulin C-peptide decreased ": 30.53262809322468, "Intertrigo ": 10.219235685578544, "Ketoacidosis ": 208.16694170313176, "Ketonuria ": 68.26688936820682, "Ketosis ": 77.69950993819063, "Kidney infection ": 2.6110560738932667, "Klebsiella infection ": 2.844029121903007, "Knee operation ": 3.520265529217454, "Kussmaul respiration ": 18.06378038793672, "Lactic acidosis ": 4.446969200970843, "Lacunar infarction ": 3.910781484904638, "Latent autoimmune diabetes in adults ": 22.349252911197397, "Leg amputation ": 16.604985945736537, "Leukocyturia ": 11.060299917517954, "Lichen sclerosus ": 25.352570229184767, "Limb amputation ": 35.11456236835319, "Limb injury ": 2.391419129335128, "Lipase abnormal ": 14.42509155329727, "Lipase increased ": 2.6615758487331567, "Localised infection ": 3.171400740687021, "Low cardiac output syndrome ": 11.16674980490368, "Low density lipoprotein increased ": 2.551729823695472, "Metabolic acidosis ": 9.694514896800808, "Metabolic surgery ": 6.7273094002582825, "Microalbuminuria ": 5.327332361719206, "Micturition disorder ": 3.537439051433315, "Micturition frequency decreased ": 5.963639909434095, "Micturition urgency ": 12.70208558453816, "Mucosal dryness ": 2.0359780547263244, "Muscle atrophy ": 2.2793850735649914, "Myocardial infarction ": 3.609380148821226, "N-terminal prohormone brain natriuretic peptide increased ": 2.4423761711162544, "Near death experience ": 2.1414185224319247, "Necrosis ": 3.0995234714103725, "Necrotising fasciitis ": 75.1263403376006, "Necrotising oesophagitis ": 17.155465778462478, "Necrotising soft tissue infection ": 176.97175248692744, "Neoplasm malignant ": 3.296049819745635, "Nephrectomy ": 2.2052717099337267, "Nephritis ": 2.4302467603621647, "Nephrolithiasis ": 2.352933059557922, "Nocturia ": 13.61202647174065, "Oedema genital ": 8.814384670206216, "Oral fungal infection ": 6.742257935427442, "Orchidectomy ": 42.51197865267931, "Orchitis ": 19.368833094296768, "Osteomyelitis ": 4.389947286909426, "Pancreatic carcinoma ": 2.0858960275960685, "Pancreatitis ": 3.912976009527797, "Pancreatitis acute ": 2.162766703271535, "Pancreatitis necrotising ": 7.3300810337044915, "Pancreatitis relapsing ": 7.578264123282696, "Paraphimosis ": 104.49675120507555, "Pelvic abscess ": 8.888345771976178, "Pelvic inflammatory disease ": 8.329751717612467, "Penile burning sensation ": 59.22820325825489, "Penile dermatitis ": 80.93120106568271, "Penile discharge ": 39.36406010924392, "Penile discomfort ": 129.76614203802706, "Penile erythema ": 99.12479650292588, "Penile haemorrhage ": 6.312966461825265, "Penile infection ": 151.01235003664917, "Penile oedema ": 8.287050317828355, "Penile pain ": 11.245915468023275, "Penile swelling ": 27.867841269942637, "Penile ulceration ": 14.18390522947653, "Penis disorder ": 21.24784154423476, "Penis injury ": 23.740224185475597, "Perineal abscess ": 76.50574730028949, "Perineal infection ": 98.3797168180772, "Perineal pain ": 16.14107894428279, "Perineal swelling ": 384.6145035528135, "Peripheral artery occlusion ": 4.523240552508843, "Perirectal abscess ": 9.23377281705044, "Phimosis ": 259.70850349443134, "Physical assault ": 2.784938184573706, "Pollakiuria ": 25.511179269782065, "Polycythaemia ": 15.260105884660032, "Polydipsia ": 10.49512181479786, "Polyuria ": 21.097602727970973, "Post procedural complication ": 4.688576365666854, "Post procedural infection ": 2.5003885749015864, "Prerenal failure ": 6.8974527321722645, "Proctalgia ": 2.5489897241530137, "Prostatic abscess ": 47.39973294230192, "Prostatitis ": 24.711531922659635, "Prostatomegaly ": 5.080528071851669, "Protein urine ": 5.081013445716344, "Pruritus genital ": 111.44988062790392, "Pustule ": 2.03682098002026, "Pyelonephritis ": 24.80398482862736, "Pyelonephritis acute ": 17.50308089665486, "Red blood cell count increased ": 3.4860689827184874, "Renal abscess ": 15.970323319193897, "Renal function test abnormal ": 2.1647041880751776, "Renal pain ": 2.7928861628447725, "Renal tubular acidosis ": 2.0410090893963377, "Respiratory acidosis ": 4.167455347222631, "Scrotal abscess ": 136.35646859542538, "Scrotal infection ": 35.8951595431591, "Scrotal swelling ": 7.435794129940771, "Sepsis ": 4.846385217198344, "Septic shock ": 2.9758092744380487, "Shoulder arthroplasty ": 2.758386087465418, "Shoulder operation ": 2.47162077925628, "Skin abrasion ": 2.3003379658857126, "Skin fissures ": 5.790524039529504, "Skin odour abnormal ": 4.702889970042481, "Skin ulcer ": 3.098002610002665, "Starvation ": 7.057045069208138, "Starvation ketoacidosis ": 107.17586925621686, "Streptococcal infection ": 2.179778881654666, "Surgery ": 4.061396031008372, "Systemic candida ": 6.174864984212487, "Tachypnoea ": 3.2400753905934185, "Testicular abscess ": 98.2258618932756, "Thirst ": 15.869570830808316, "Toe amputation ": 36.553059754494726, "Troponin increased ": 4.947883235655883, "Urethral pain ": 8.244784523169459, "Urethritis ": 43.2396294930749, "Urethritis noninfective ": 24.27721596019476, "Urinary incontinence ": 3.713138474728701, "Urinary tract candidiasis ": 53.39968978486581, "Urinary tract discomfort ": 16.73473236229109, "Urinary tract infection ": 22.634416998893684, "Urinary tract infection bacterial ": 7.238293910795768, "Urinary tract infection fungal ": 48.17769250858611, "Urinary tract inflammation ": 12.089913089006986, "Urinary tract obstruction ": 4.068522557079353, "Urine abnormality ": 4.753768613097327, "Urine ketone body ": 132.541890987336, "Urine ketone body present ": 48.30644250438396, "Urine odour abnormal ": 10.206520759744848, "Urine output increased ": 25.12187277753988, "Urogenital disorder ": 69.00186692361179, "Urogenital infection bacterial ": 72.46077711316912, "Urogenital infection fungal ": 70.32229852377806, "Urosepsis ": 55.65477883895014, "Vaginal abscess ": 32.85275363247904, "Vaginal infection ": 36.94988496707706, "Vascular graft ": 11.26711554463185, "Ventricular asystole ": 16.606899204954473, "Vulval abscess ": 56.10683930616301, "Vulvitis ": 40.03715347361926, "Vulvovaginal burning sensation ": 15.014319815932826, "Vulvovaginal candidiasis ": 32.133074110426506, "Vulvovaginal discomfort ": 9.264102495907665, "Vulvovaginal dryness ": 5.678772535928389, "Vulvovaginal erythema ": 15.98956729932267, "Vulvovaginal inflammation ": 7.057045069208138, "Vulvovaginal mycotic infection ": 74.68813130779185, "Vulvovaginal pain ": 6.12018106651269, "Vulvovaginal pruritus ": 51.78722738505421, "Vulvovaginal swelling ": 21.93893996300957, "Vulvovaginitis ": 130.673196223988, "Weight decreased ": 5.682311977900619, "pH body fluid abnormal ": 93.02030402710128} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/606.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/606.json new file mode 100644 index 00000000000..a85af198650 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/606.json @@ -0,0 +1 @@ +{"Arrhythmia ": 5.971439602828725, "COVID-19 ": 3.054348564843507, "COVID-19 immunisation ": 14.321378354340272, "Chills ": 2.671156983359535, "Disturbance in attention ": 2.745208400414902, "Dizziness ": 2.6086307923131318, "Fatigue ": 2.16431446568056, "Feeling hot ": 4.440165533056033, "Influenza ": 8.72604600768434, "Injection site pain ": 3.707249111909928, "Injection site swelling ": 2.2167763259379547, "Interchange of vaccine products ": 9.584459182728647, "Limb discomfort ": 12.778438947000025, "Lymphadenopathy ": 2.252891895787213, "Myalgia ": 2.150954659312319, "SARS-CoV-2 test positive ": 26.0661657894208, "Suspected COVID-19 ": 10.87784496951629, "Tachycardia ": 3.4345710184958547, "Visual impairment ": 2.5679817323795118} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/607.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/607.json new file mode 100644 index 00000000000..59f5fcf0902 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/607.json @@ -0,0 +1 @@ +{"Anterior chamber inflammation ": 172.84936584715766, "Blindness transient ": 63.62272212748079, "Corneal disorder ": 102.31673199909172, "Disease progression ": 19.634207040921208, "Drug ineffective for unapproved indication ": 12.579644328084632, "Dyschromatopsia ": 1303.6266700816795, "Eye pain ": 15.376187844445644, "Macular detachment ": 1078.3765261200688, "Macular hole ": 4742.731750220694, "Macular oedema ": 65.3759087378149, "Metamorphopsia ": 562.3379355361022, "Night blindness ": 897.1759333914919, "Ocular hyperaemia ": 13.713770737041854, "Optical coherence tomography abnormal ": 2182.0966030865507, "Photophobia ": 29.87340712707928, "Photopsia ": 406.7610016231488, "Pupillary reflex impaired ": 415.64417923908906, "Retinal detachment ": 309.59997281586044, "Retinal injury ": 1680.568291975413, "Retinal oedema ": 295.54086089338927, "Retinal tear ": 547.28167322381, "Retinogram abnormal ": 1513.6379296903715, "Rhegmatogenous retinal detachment ": 1503.9515480011232, "Subretinal fluid ": 2367.188877863163, "Therapy non-responder ": 19.68971586657152, "Vision blurred ": 19.493050935978797, "Visual acuity reduced ": 313.8552977799534, "Visual acuity reduced transiently ": 569.8555452218397, "Visual field defect ": 77.33559571568176, "Visual impairment ": 27.21344601221359, "Vitreous floaters ": 214.3381931016016} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/608.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/608.json new file mode 100644 index 00000000000..96b7ca510c7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/608.json @@ -0,0 +1 @@ +{"Muscle spasticity ": 480.8180825742653, "Overdose ": 28.387805474557503} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/609.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/609.json new file mode 100644 index 00000000000..bfd68ffcda3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/609.json @@ -0,0 +1 @@ +{"Accidental overdose ": 2.726638118135794, "Acute respiratory distress syndrome ": 2.651218122067656, "Altered state of consciousness ": 2.2973471479308376, "Anaemia ": 4.924874076678786, "Blood pressure decreased ": 3.452865592008124, "Bone marrow failure ": 6.176863200144685, "Bone pain ": 2.434318070513375, "Cellulitis ": 3.11699386572926, "Circulatory collapse ": 2.558965281842434, "Cystitis haemorrhagic ": 10.950967666655863, "Death ": 2.0580944392677543, "Decreased appetite ": 2.3674445990351285, "Dehydration ": 2.0130434384440963, "Diarrhoea ": 3.213987622470328, "Disease progression ": 13.068153446020697, "Disseminated intravascular coagulation ": 16.614566679473494, "Enteritis ": 6.867742130091692, "Enterocolitis ": 8.001727037253637, "Extravasation ": 22.20810187434947, "Febrile bone marrow aplasia ": 16.468389662816666, "Febrile neutropenia ": 85.26930555549139, "Gastrointestinal haemorrhage ": 2.072903768233016, "Haematotoxicity ": 10.568738710373212, "Haematuria ": 8.131462164610689, "Haemoglobin decreased ": 2.455683935165222, "Haemorrhage urinary tract ": 10.794935028984996, "Hormone-refractory prostate cancer ": 42.107361549761535, "Hydronephrosis ": 14.960358500526286, "Hypocalcaemia ": 3.3145491172610684, "Ileus ": 9.83694704904808, "Inappropriate antidiuretic hormone secretion ": 3.752455165499272, "Interstitial lung disease ": 6.140435186089639, "Intestinal perforation ": 7.166339622856966, "Ischaemic hepatitis ": 43.06972406313073, "Leukopenia ": 6.748448957639394, "Malignant neoplasm progression ": 2.209448956152972, "Metastases to bone ": 10.591024199035726, "Metastases to liver ": 3.2748000465265856, "Metastasis ": 10.476867917269118, "Mucosal inflammation ": 4.148808423897667, "Multiple organ dysfunction syndrome ": 4.186135230579333, "Myelosuppression ": 5.919793816580693, "Neuropathy peripheral ": 5.723231717497308, "Neurotoxicity ": 3.971893911862381, "Neutropenia ": 16.757678316307842, "Neutropenic infection ": 65.4639443293483, "Neutropenic sepsis ": 12.716553873488872, "Neutrophil count decreased ": 28.33011497075228, "Osteomyelitis ": 5.034794245238509, "Osteonecrosis of jaw ": 12.055093389380763, "Pancytopenia ": 5.253379999154351, "Performance status decreased ": 8.830975425837613, "Physical deconditioning ": 7.954452546646241, "Platelet count decreased ": 5.355441108827202, "Pleural effusion ": 2.191063587946617, "Pneumonia ": 2.827472358226308, "Pneumonia aspiration ": 2.280098098708521, "Pneumonia bacterial ": 16.179885360866663, "Product dispensing error ": 6.758245194668755, "Product storage error ": 3.4817700319491998, "Prostate cancer ": 8.027783234947151, "Prostate cancer metastatic ": 20.39173520269268, "Prostatic specific antigen increased ": 73.54458657594722, "Respiratory failure ": 2.4017474424620646, "Sepsis ": 9.260466592326614, "Septic shock ": 19.48714477896724, "Shock ": 4.774154670816518, "Taste disorder ": 2.8075736469532875, "Thrombocytopenia ": 4.455121140243636, "Tumour lysis syndrome ": 8.03179958758369, "White blood cell count decreased ": 5.9411736485686095, "White blood cell count increased ": 2.412244413109325} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/61.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/61.json new file mode 100644 index 00000000000..fec7088858d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/61.json @@ -0,0 +1 @@ +{"Asthenia ": 5.698428346766091, "Nausea ": 4.799154589596066, "Neutropenia ": 25.443533426929605} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/610.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/610.json new file mode 100644 index 00000000000..1d2f6827a97 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/610.json @@ -0,0 +1 @@ +{"Angioedema ": 79.35818143004069, "Death ": 13.770272579478965} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/611.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/611.json new file mode 100644 index 00000000000..1a7cab89e48 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/611.json @@ -0,0 +1 @@ +{"Haemarthrosis ": 651.8662961820921, "Haemorrhage ": 67.11805663276392} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/612.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/612.json new file mode 100644 index 00000000000..6e3aaa21db2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/612.json @@ -0,0 +1 @@ +{"Abdominal pain upper ": 3.1723417888235743, "Dysgeusia ": 14.826606885304164, "Dysphagia ": 8.012679659514697, "Inappropriate schedule of product administration ": 8.710665684569504, "Infection susceptibility increased ": 534.7258899892737, "Oesophageal candidiasis ": 321.3204320895036, "Off label use ": 4.678523612440918, "Oral candidiasis ": 97.95356823430126} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/613.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/613.json new file mode 100644 index 00000000000..8ce936a4b32 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/613.json @@ -0,0 +1 @@ +{"Disease progression ": 9.9664621922306, "Neuropathy peripheral ": 6.672731702963764, "Platelet count decreased ": 5.804759821534628, "Thrombocytopenia ": 4.3886846406466855} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/614.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/614.json new file mode 100644 index 00000000000..6b9a187576e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/614.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.9832252135417776, "Abdominal pain ": 3.35798523299829, "Abdominal pain upper ": 3.1428976657812084, "Abnormal behaviour ": 2.1434377719629483, "Abortion induced ": 5.159001697457107, "Abortion spontaneous ": 5.801758721123785, "Acne ": 26.78271859512774, "Affect lability ": 2.6457417063892894, "Affective disorder ": 13.553637059290477, "Aggression ": 3.910124136844948, "Agitation ": 3.207171296121833, "Alanine aminotransferase increased ": 7.557386971503261, "Anger ": 7.849411130282721, "Anxiety ": 2.6593063058710427, "Apathy ": 3.220992855313835, "Aspartate aminotransferase increased ": 6.568300969711188, "Attention deficit hyperactivity disorder ": 10.769078587062983, "Autoimmune hepatitis ": 3.8506893861534826, "Behaviour disorder ": 17.599291055584022, "Bilirubin conjugated increased ": 7.5603166059571665, "Blood alkaline phosphatase increased ": 9.739479640647222, "Blood bilirubin increased ": 11.870065083431642, "Blood bilirubin unconjugated increased ": 25.482286294343577, "Blood creatine phosphokinase increased ": 6.204739312870132, "Body mass index increased ": 20.14572561615075, "Brain fog ": 4.232709832453297, "Breast enlargement ": 6.036611280745191, "Breast pain ": 2.49146576847176, "Bronchial secretion retention ": 21.185854291791117, "Butterfly rash ": 25.45847591435244, "Cataract ": 2.713989314188213, "Chalazion ": 247.67653199874184, "Cholecystitis acute ": 11.637961427310794, "Cholelithiasis ": 3.912263863510308, "Chromaturia ": 2.060491027700013, "Congenital absence of cranial vault ": 625.8334028246551, "Constipation ": 2.3679003248743653, "Cystic fibrosis ": 191.58883546167337, "Delusion ": 2.3581720156141506, "Depressed mood ": 8.44636609018098, "Depression ": 3.9648397358436087, "Dermatitis acneiform ": 13.767655817524668, "Dermatitis allergic ": 2.987810390436469, "Distal intestinal obstruction syndrome ": 742.5940736928019, "Disturbance in attention ": 3.035506800501325, "Drug eruption ": 4.402742838133394, "Drug-induced liver injury ": 4.285687497838473, "Dry eye ": 7.32673488039737, "Emotional disorder ": 3.638862564834876, "Eosinophilia ": 2.3575343863616145, "Epididymitis ": 26.201847336015497, "Exposure during pregnancy ": 5.294749480365308, "Flatulence ": 2.6677677561854525, "Forced expiratory volume decreased ": 40.29183501070369, "Gamma-glutamyltransferase increased ": 4.973081904227797, "Gestational diabetes ": 10.351004210338186, "Gilbert's syndrome ": 523.4614025466639, "Gynaecomastia ": 3.0776404721652773, "Haemoptysis ": 8.355507874314938, "Hemiplegic migraine ": 50.70549145749571, "Hepatic cirrhosis ": 3.7729948421462094, "Hepatic cytolysis ": 5.696746927502789, "Hepatic enzyme increased ": 3.790087792149658, "Hepatic failure ": 2.106941850169829, "Hepatocellular injury ": 5.460397552586802, "Hordeolum ": 63.25695761486933, "Hospitalisation ": 7.685288111599751, "Hyperbilirubinaemia ": 14.2892959181756, "Hypertransaminasaemia ": 14.810229418133726, "Idiopathic intracranial hypertension ": 20.23402519496648, "Illness ": 2.2729561959105795, "Impulsive behaviour ": 16.262998645444394, "Increased bronchial secretion ": 10.38566273672922, "Infection ": 3.036488738290396, "Infective pulmonary exacerbation of cystic fibrosis ": 108.21878536046133, "Initial insomnia ": 21.773676748792305, "Insomnia ": 2.5674365980347686, "Intensive care ": 24.113698814046117, "Intentional self-injury ": 4.271506978235504, "Intestinal obstruction ": 2.6648762699663635, "Intracranial pressure increased ": 17.41441473106559, "Irritability ": 4.920430549778263, "Listless ": 3.142555152760239, "Lithiasis ": 84.97749147897477, "Liver function test abnormal ": 2.5349645074168983, "Liver function test increased ": 9.759204938114392, "Liver transplant ": 14.72189004861564, "Lower respiratory tract infection ": 17.36542213956028, "Lung disorder ": 3.6287429421404673, "Mental disorder ": 7.672477799744856, "Middle insomnia ": 9.652365329911897, "Mood altered ": 7.659714375123392, "Mood swings ": 6.109029478646402, "Nasal congestion ": 2.061211464050231, "Nightmare ": 2.7359863225730057, "Ocular discomfort ": 2.4273492309064038, "Orchitis ": 32.56816283301198, "Panic attack ": 2.81115648154628, "Papilloedema ": 19.145455473209356, "Personality change ": 4.700152995709196, "Pneumothorax ": 2.9048045081518765, "Poor quality sleep ": 3.436273604294017, "Portal hypertension ": 10.467773024288835, "Productive cough ": 15.529316403851697, "Pseudomonas infection ": 10.942568534312135, "Psychomotor hyperactivity ": 5.676928787233578, "Pulmonary function test decreased ": 28.03284423729225, "Pulmonary haemorrhage ": 7.2790766469358115, "Pulmonary pain ": 3.699865485357378, "Rash ": 2.970779110526958, "Rash erythematous ": 2.322508195490274, "Rash macular ": 3.2696538704262386, "Rash maculo-papular ": 5.524423925826596, "Rash pruritic ": 5.957822623776094, "Restlessness ": 2.037527893989658, "SARS-CoV-2 test positive ": 3.046375783943583, "Secretion discharge ": 6.9055992630144605, "Self-destructive behaviour ": 6.291342630540044, "Sleep disorder ": 6.284016319867672, "Sleep terror ": 16.42130161293499, "Sputum increased ": 63.803963797173466, "Steatorrhoea ": 66.80992277013985, "Suicidal ideation ": 2.8808845881947107, "Surgery ": 8.297899944759154, "Sweat test abnormal ": 755.9659322881746, "Testicular pain ": 22.41079218541327, "Tic ": 6.391404483687637, "Transaminases increased ": 10.850575786748836, "Transplant ": 29.988371196912222, "Vaginal discharge ": 2.264826345714297, "Viral infection ": 6.68377693789446, "Vitamin A increased ": 1523.9929785452157} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/615.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/615.json new file mode 100644 index 00000000000..b0f6d05b24d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/615.json @@ -0,0 +1 @@ +{"Abdominal hernia ": 5.408047478773876, "Abdominal tenderness ": 2.4648132091433794, "Abortion induced ": 12.279363035061952, "Abortion spontaneous ": 3.588582679833056, "Accidental overdose ": 2.016891151012745, "Acquired immunodeficiency syndrome ": 61.78360871536852, "Acrochordon ": 29.81291877964241, "Acute hepatic failure ": 3.1796066045665903, "Acute kidney injury ": 3.418761654975793, "Acute respiratory distress syndrome ": 5.862990186903089, "Adrenal insufficiency ": 3.815296748426225, "Adrenal suppression ": 10.21073323652273, "Alanine aminotransferase increased ": 2.0762488656180764, "Amylase increased ": 3.4756196684254057, "Anaemia ": 2.529848075828755, "Anaemia macrocytic ": 5.241832436686096, "Anogenital warts ": 55.25217805853367, "Anti-neutrophil cytoplasmic antibody positive vasculitis ": 16.356085092997674, "Antiviral drug level above therapeutic ": 303.6379803569546, "Arterial spasm ": 60.86330433956943, "Aspartate aminotransferase increased ": 2.118117043770688, "Aspiration bursa ": 1041.7043582125457, "Atrial septal defect ": 3.098005466921921, "Atrioventricular block ": 2.532749644549217, "Atrioventricular block complete ": 3.344064698185585, "Atrioventricular block first degree ": 3.889540288050576, "Autoimmune thyroiditis ": 5.556267392289751, "Behaviour disorder ": 2.563454208762449, "Benign prostatic hyperplasia ": 11.598803509844087, "Bilirubin conjugated increased ": 7.594087121217274, "Biopsy liver abnormal ": 32.78124675914216, "Blood HIV RNA increased ": 24.328441077293157, "Blood bilirubin increased ": 3.004924032435068, "Blood bilirubin unconjugated increased ": 16.717448987301786, "Blood creatinine abnormal ": 4.242224377420899, "Blood creatinine increased ": 2.280655492006956, "Blood lactate dehydrogenase increased ": 2.698795790010943, "Blood lactic acid increased ": 6.3248633928658045, "Blood triglycerides increased ": 12.050641833005118, "Bone demineralisation ": 3.9853695661094974, "Bone density decreased ": 5.301092496891122, "Bone loss ": 8.44481672202837, "Bone marrow failure ": 2.829445608407649, "Bone metabolism disorder ": 92.4327376636144, "Bradycardia ": 2.106316986404012, "Breath odour ": 7.010672306491818, "CD4 lymphocytes decreased ": 37.35254727877938, "COVID-19 treatment ": 465.56232101939474, "Cachexia ": 14.552465989513538, "Caesarean section ": 8.449346454504589, "Cardiac murmur ": 2.420492024510065, "Carotid artery stenosis ": 5.318978865928611, "Cerebellar syndrome ": 8.909395589077814, "Cerebral toxoplasmosis ": 23.632172651830643, "Cholestasis ": 6.010480822929652, "Chronic kidney disease ": 3.676660290626268, "Coarctation of the aorta ": 12.568484177670154, "Congenital anomaly ": 3.557491399146695, "Congenital aplasia ": 10.600956493436724, "Congenital hearing disorder ": 83.80333773959204, "Coronavirus infection ": 3.782319001564674, "Cortisol decreased ": 11.619649308298085, "Cryptorchism ": 10.591188329042431, "Cushing's syndrome ": 47.39549579301694, "Cushingoid ": 15.805901140143929, "Cyst ": 2.8369020850759097, "Cytomegalovirus chorioretinitis ": 7.165709482072099, "Cytomegalovirus infection ": 2.1118791651262017, "Developmental delay ": 4.219132989062504, "Diarrhoea ": 3.267668496501212, "Drug interaction ": 4.375190700612314, "Drug level changed ": 22.53118209201996, "Drug level decreased ": 2.4322984104551035, "Drug level increased ": 7.890271109023095, "Drug-induced liver injury ": 2.1512206564674687, "Dyslipidaemia ": 22.44941901848393, "Dysmorphism ": 2.923570590488551, "Economic problem ": 2.5094102097261235, "Electrocardiogram QT prolonged ": 6.959521425242634, "Electrocardiogram abnormal ": 2.806224200059849, "Electrolyte imbalance ": 2.969413682696282, "Encephalitis ": 2.452420451529373, "Endotracheal intubation ": 15.18056442012873, "Ergot poisoning ": 43.67966280308951, "Erythema nodosum ": 3.4245530662800414, "Eyelid ptosis ": 2.81837382571774, "Fanconi syndrome ": 56.59854860520182, "Fanconi syndrome acquired ": 11.446679407010723, "Fat redistribution ": 46.16965426786876, "Foetal death ": 5.343209436172897, "Foetal distress syndrome ": 6.998429733696829, "Foetal exposure during pregnancy ": 4.508901934644183, "Foetal growth restriction ": 4.395648781219613, "Foot fracture ": 2.9285158116091585, "Fracture ": 11.153506224471576, "Gamma-glutamyltransferase increased ": 2.515223167328671, "Gastritis ": 2.915328306687168, "Gastrointestinal disorder ": 2.577004540108397, "Glomerular filtration rate abnormal ": 6.550554786667801, "Glycosuria ": 7.481035001476095, "HIV infection ": 14.630431897388243, "HIV test positive ": 26.43780773610682, "Hepatic cancer ": 4.897371608997988, "Hepatic cytolysis ": 12.533421129606683, "Hepatic failure ": 2.8120481449211856, "Hepatic lesion ": 4.611709795982127, "Hepatitis ": 4.738105560542512, "Hepatitis acute ": 2.9289878970262007, "Hepatocellular injury ": 7.009012108048632, "Hepatomegaly ": 4.778726089406887, "Hepatosplenomegaly ": 4.139265663746004, "Hepatotoxicity ": 3.965942206987117, "Herpes virus infection ": 2.8073357954289966, "Hip fracture ": 3.121032832714402, "Hip surgery ": 4.531528109753318, "Hodgkin's disease ": 5.964419480244043, "Humerus fracture ": 11.830859618891978, "Hydrocephalus ": 3.872752674717096, "Hyperbilirubinaemia ": 11.241384669984058, "Hypercholesterolaemia ": 4.609767340027047, "Hyperlactacidaemia ": 18.560511792706837, "Hyperlipasaemia ": 15.731338313306871, "Hyperlipidaemia ": 4.686706307940899, "Hypertransaminasaemia ": 11.52045380916123, "Hypertriglyceridaemia ": 57.19613741529389, "Hypophagia ": 2.3749194230790414, "Hypophosphataemia ": 12.548102452650392, "Hypospadias ": 5.774242417544768, "Ileus paralytic ": 5.4228912935829765, "Immune reconstitution inflammatory syndrome ": 24.574738601049937, "Immunosuppressant drug level increased ": 13.96089286266653, "Incoherent ": 2.9995746638831653, "Jaundice ": 4.996178392122745, "Kaposi's sarcoma ": 16.64967424057314, "Kidney infection ": 5.590742591530742, "Kidney malformation ": 27.203422015822767, "Lactic acidosis ": 5.48629938283975, "Lipase increased ": 6.006202476849299, "Lipids increased ": 14.103983110461328, "Lipoatrophy ": 10.605008895367536, "Lipodystrophy acquired ": 20.463836895459032, "Live birth ": 7.092025400495164, "Liver function test abnormal ": 4.857936210709581, "Long QT syndrome ": 25.918491042939127, "Lymphoma ": 2.7992081760117733, "Lymphopenia ": 2.693984630671448, "Magnetic resonance imaging head abnormal ": 6.922696514695927, "Mechanical ventilation ": 15.43189770366376, "Meningitis cryptococcal ": 16.869321207753014, "Mitochondrial toxicity ": 16.355617336897613, "Multiple fractures ": 6.505589673364803, "Mycobacterium avium complex infection ": 7.528109052886492, "Nephrogenic diabetes insipidus ": 5.5308123837868814, "Nephropathy toxic ": 2.819130014787876, "Non-Hodgkin's lymphoma ": 3.196539742375133, "Normal newborn ": 3.082574860960762, "Nystagmus ": 2.1669977229298123, "Oesophageal atresia ": 33.00140241118983, "Oesophageal candidiasis ": 12.206937488055887, "Off label use ": 3.2602526748048724, "Oliguria ": 4.35374220437765, "Oral candidiasis ": 2.0491084178176253, "Organising pneumonia ": 3.4972754920815365, "Osteogenesis imperfecta ": 42.532756143564455, "Osteomalacia ": 4.4159530769092905, "Osteonecrosis ": 10.440469673963497, "Osteopenia ": 3.622578632293048, "Osteoporosis ": 6.879071022701591, "Pancreatitis ": 2.961680146897196, "Pancreatitis acute ": 3.4857999729663933, "Patella fracture ": 12.765750670362692, "Patent ductus arteriosus ": 4.919850697279562, "Peripheral ischaemia ": 4.92907737695531, "Peripheral sensorimotor neuropathy ": 10.272232817797898, "Personality disorder ": 6.244526468310814, "Pneumocystis jirovecii pneumonia ": 4.44212250808757, "Portal hypertension ": 4.433366126230136, "Pregnancy on contraceptive ": 22.731393287479904, "Premature baby ": 3.619797209126382, "Premature delivery ": 2.7104037076259693, "Premature labour ": 4.942252506738883, "Premature rupture of membranes ": 14.324702326996333, "Progressive multifocal leukoencephalopathy ": 11.558470089264862, "Protein total abnormal ": 7.672892858527975, "Proteinuria ": 2.6129317627185995, "Psychiatric symptom ": 3.2095535039873906, "Pulmonary tuberculosis ": 9.92958838410139, "Pulse absent ": 3.3577334634366665, "Pyelocaliectasis ": 27.603564096551345, "Renal disorder ": 2.422920600686157, "Renal dysplasia ": 46.50101151080655, "Renal failure ": 4.21656798986675, "Renal injury ": 8.145178035217796, "Renal tubular acidosis ": 15.663948247430408, "Renal tubular disorder ": 10.351320836055802, "Renal tubular necrosis ": 8.266864373956615, "Respiratory failure ": 2.354160410974297, "Respiratory rate increased ": 2.125209410227226, "Rhabdomyolysis ": 2.731748008480644, "Rhinitis allergic ": 2.2084972018753803, "Shoulder fracture ": 3.127279308569782, "Sinus bradycardia ": 6.114027334292162, "Skeletal injury ": 8.029968308061274, "Skin striae ": 11.070606604495058, "Small for dates baby ": 7.863935946196288, "Stillbirth ": 20.99932324733667, "Strabismus ": 5.1745785556216495, "Sudden death ": 2.165854177618717, "Therapeutic response unexpected ": 4.643350187378398, "Tooth disorder ": 2.513116110078061, "Tooth fracture ": 3.0837466258826325, "Tooth loss ": 4.52737054330724, "Toxic skin eruption ": 2.725761162499714, "Toxoplasmosis ": 16.600565210882344, "Transaminases increased ": 4.441487837264154, "Tricuspid valve incompetence ": 3.030593318431765, "Trisomy 21 ": 15.563961701253438, "Tuberculosis ": 4.129926300606878, "Unevaluable event ": 2.5818743854755954, "Upper limb fracture ": 4.229969470959063, "Urinary tract obstruction ": 8.909395589077814, "Varices oesophageal ": 12.152385530181544, "Ventricular septal defect ": 5.871981359906349, "Viral load increased ": 25.4041516903568, "Virologic failure ": 4.068283849294812, "Walking disability ": 6.187372991036302} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/616.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/616.json new file mode 100644 index 00000000000..cacf4209b65 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/616.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 2.9975189812819782, "Acne ": 4.158813117213652, "Alanine aminotransferase increased ": 3.2811975552251385, "Aspartate aminotransferase increased ": 2.643279813657028, "Chest discomfort ": 2.281922482141893, "Cough ": 2.7525069827682493, "Cystic fibrosis ": 602.1557235459907, "Cystic fibrosis respiratory infection suppression ": 1163.827272484795, "Exposure during pregnancy ": 3.5330318644832017, "Forced expiratory volume decreased ": 39.84352076104096, "Haemoptysis ": 18.93344787110714, "Hepatic enzyme increased ": 2.1111001056381147, "Hospitalisation ": 37.40684361066212, "Illness ": 5.284251582870279, "Infection ": 9.354718643969102, "Infective pulmonary exacerbation of cystic fibrosis ": 1090.7775353011405, "Influenza ": 3.195248964567396, "Intestinal obstruction ": 5.374002224770848, "Lower respiratory tract infection ": 15.181994393094431, "Lung disorder ": 2.422095250119124, "Lung transplant ": 84.26020092909432, "Mental disorder ": 4.193822873079055, "Nasopharyngitis ": 3.595319619163448, "Oxygen saturation decreased ": 2.0201211412468534, "Pancreatitis ": 6.814419662396732, "Pancreatitis acute ": 2.57172234377964, "Pneumonia ": 7.998431111007434, "Pneumothorax ": 9.462653878567552, "Product dose omission issue ": 7.09454527053352, "Productive cough ": 4.167342664848204, "Pseudomonas infection ": 30.343285991339783, "Pulmonary function test decreased ": 190.13814207809693, "Respiratory failure ": 3.5131431515982703, "Sinusitis ": 6.084885762412976, "Surgery ": 10.038641397065984, "Transaminases increased ": 2.312189477656727, "Treatment noncompliance ": 6.345985023492354, "Viral infection ": 12.728518357098013} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/617.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/617.json new file mode 100644 index 00000000000..76580cf4b8d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/617.json @@ -0,0 +1 @@ +{"Chills ": 5.29118140427494, "Off label use ": 9.696878321314324} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/618.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/618.json new file mode 100644 index 00000000000..c22b96af1a6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/618.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 5.454048554662987, "Angioedema ": 8.718896859635164, "Blood pressure increased ": 7.1385618572660565, "Cardiac failure ": 2.4031115456880623, "Cough ": 3.5418484600312663, "Hyperkalaemia ": 26.84115267850989, "Hypertension ": 2.3184099723719807, "Hyponatraemia ": 6.337541657451082, "Hypotension ": 6.889319793358886, "Muscle spasms ": 2.107211367889008, "Nasopharyngitis ": 2.2712750421827206, "Neutropenia ": 3.388512342282296, "Orthostatic hypotension ": 9.627466976359532, "Presyncope ": 11.031226228445153, "Renal failure ": 2.037714341154249, "Swelling face ": 3.0261685818216084, "Syncope ": 2.7685604600654976, "Vertigo ": 2.2446032418181536, "Vulvovaginal candidiasis ": 155.6799966179927, "Weight decreased ": 2.619495660694392} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/619.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/619.json new file mode 100644 index 00000000000..194017ecf99 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/619.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 8.98497758771396, "Angioedema ": 6.88749549810547, "Blood pressure increased ": 2.973145483302433, "Blood sodium decreased ": 37.23097521524178, "Bradycardia ": 4.744831603235164, "Drug interaction ": 2.643397773288292, "Hyperkalaemia ": 12.970275288876197, "Hypokalaemia ": 14.04686425956964, "Hyponatraemia ": 22.422652401041617, "Hypotension ": 10.432705039241588, "Lactic acidosis ": 11.08753621334067, "Presyncope ": 6.236679600672139, "Syncope ": 4.962151924045536, "Vertigo ": 3.800464072838746} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/62.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/62.json new file mode 100644 index 00000000000..95975aaa947 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/62.json @@ -0,0 +1 @@ +{"Syncope ": 4.986117072753408} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/620.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/620.json new file mode 100644 index 00000000000..65421c1984b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/620.json @@ -0,0 +1 @@ +{"Application site erythema ": 167.28006146326328, "Application site pain ": 9.698582669459917, "Application site pruritus ": 266.6039195958152, "Application site rash ": 130.10739102167346, "Application site reaction ": 68.09048612112686, "Dry mouth ": 11.516030169726738, "Erythema ": 2.96951667317266, "Product adhesion issue ": 266.19442500055175, "Product complaint ": 13.701573838435705, "Vision blurred ": 4.3785248553856} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/621.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/621.json new file mode 100644 index 00000000000..8f6768bfde2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/621.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 5.757633111326372, "Abortion ": 4.8980690023963165, "Abortion induced ": 6.113819021648333, "Abortion missed ": 2.200638191502839, "Abortion spontaneous ": 4.10725222549644, "Accident ": 2.2705055821711326, "Accidental exposure to product ": 6.332085968901976, "Accidental exposure to product by child ": 2.6672596517651765, "Accidental overdose ": 2.666038507763053, "Acute psychosis ": 9.31230073203831, "Adverse drug reaction ": 4.460738890619583, "Affect lability ": 4.184311819798195, "Affective disorder ": 11.313819744117389, "Aggression ": 14.279978471850908, "Agitation ": 4.302283570361107, "Agranulocytosis ": 3.045904103465473, "Alcohol abuse ": 2.443296946676045, "Ammonia increased ": 3.571617882690985, "Amnesia ": 3.9687668562683567, "Anger ": 11.92436980786837, "Anisocoria ": 2.8629642013006724, "Anticonvulsant drug level abnormal ": 23.470658096024444, "Anticonvulsant drug level above therapeutic ": 10.518731967446165, "Anticonvulsant drug level below therapeutic ": 15.615018967311784, "Anticonvulsant drug level decreased ": 10.621659216411144, "Anticonvulsant drug level increased ": 11.998846866472894, "Apathy ": 3.934914570091265, "Aphasia ": 3.311014649204485, "Aplastic anaemia ": 3.763056019836746, "Apraxia ": 2.399066587772965, "Arnold-Chiari malformation ": 8.755418048586838, "Aspiration ": 3.2708359419541377, "Asthenopia ": 2.401668937120003, "Ataxia ": 5.81927392658869, "Atonic seizures ": 12.088804075393584, "Atrial septal defect ": 4.035505845829315, "Atrophy ": 3.1631709644460155, "Attention deficit hyperactivity disorder ": 3.677042260618155, "Auditory disorder ": 2.074177574851125, "Aura ": 32.08587219672359, "Autism spectrum disorder ": 2.688855080281759, "Balance disorder ": 3.131108974804805, "Behaviour disorder ": 17.139801753794504, "Bradycardia neonatal ": 6.761482244214876, "Bradyphrenia ": 3.945759816831539, "Brain injury ": 3.660031903072309, "Brain lobectomy ": 75.9123719669328, "Brain malformation ": 12.299209478137312, "Brain neoplasm ": 10.139283232516377, "Brain neoplasm malignant ": 2.1869702671416995, "Brain oedema ": 2.955277752189278, "Brain operation ": 42.373009872605486, "Breast feeding ": 4.431388638403933, "Bronchial obstruction ": 2.347639169368977, "Caesarean section ": 9.446071649026395, "Calcinosis ": 2.8777720916993137, "Catatonia ": 4.751637999039611, "Cell death ": 6.621290721726646, "Cerebellar atrophy ": 3.1839108682102157, "Cerebellar syndrome ": 3.1606613623561204, "Cerebral arteriovenous malformation haemorrhagic ": 148.22088956427817, "Cerebral disorder ": 2.034030680940458, "Cerebrospinal fluid leakage ": 3.182914556276959, "Cervical vertebral fracture ": 2.0915832524353646, "Change in seizure presentation ": 34.78788256257526, "Cholestasis ": 5.182416925331632, "Clavicle fracture ": 2.5179993387763253, "Cleft lip ": 7.465381020256768, "Cleft lip and palate ": 12.778271162091464, "Cleft palate ": 8.488709476661263, "Clonic convulsion ": 2.6584577729989736, "Clonus ": 4.078720109040956, "Clumsiness ": 3.167596597194647, "Cognitive disorder ": 4.142815939588838, "Coma ": 2.6706483891023045, "Communication disorder ": 3.389744535924321, "Concussion ": 3.8571530697039513, "Confusional state ": 2.1903142775443274, "Congenital central nervous system anomaly ": 5.150417628381677, "Congenital foot malformation ": 10.300130062203094, "Congenital musculoskeletal disorder ": 3.949708801111435, "Congenital musculoskeletal disorder of limbs ": 6.049825394161366, "Convulsive threshold lowered ": 32.52956984647942, "Coordination abnormal ": 3.722329249092194, "Craniocerebral injury ": 5.531104310458717, "Craniofacial fracture ": 6.769142170063106, "Craniotomy ": 11.254252410988618, "Crying ": 2.3069982361121424, "Cryptorchism ": 6.459990192118634, "Daydreaming ": 4.345350039322753, "Deja vu ": 30.663594594694324, "Delusion ": 3.631375750954594, "Depersonalisation/derealisation disorder ": 3.327241618698468, "Depressed mood ": 3.077721966448562, "Depression ": 4.356320755418045, "Depressive symptom ": 2.3302092122696227, "Dermatitis exfoliative ": 2.302434992972663, "Developmental delay ": 5.960445685552384, "Diastolic hypotension ": 22.43941175487668, "Diet failure ": 173.16905913001102, "Diplopia ": 3.1220804640182958, "Disability ": 2.72735157256043, "Disinhibition ": 2.1520247969277677, "Disorientation ": 2.038263789998801, "Disturbance in attention ": 2.7355719311997437, "Drooling ": 3.611049959182215, "Drop attacks ": 6.2628449371298265, "Drug level below therapeutic ": 2.687856974715756, "Drug level decreased ": 4.16025677473194, "Drug level increased ": 2.210789427682471, "Drug reaction with eosinophilia and systemic symptoms ": 5.798227201115124, "Drug screen positive ": 4.244443078178049, "Drug withdrawal convulsions ": 7.364300211132145, "Dysarthria ": 2.5200735864380253, "Dyschromatopsia ": 2.3415591959483297, "Dysgraphia ": 2.641776334911854, "Dyskinesia ": 2.7995991065862977, "Dysmorphism ": 4.952809945503441, "Dysphemia ": 5.51746363042228, "Dystonia ": 2.14858851614556, "Ectopic pregnancy ": 2.0875163270944563, "Educational problem ": 5.576731603440408, "Electroencephalogram abnormal ": 7.726045408301603, "Emotional disorder ": 5.790914978456578, "Encephalitis autoimmune ": 6.880053628296253, "Encephalopathy ": 4.723352314775207, "Enuresis ": 2.9495723465806414, "Eosinophilia ": 2.706130257589919, "Epilepsy ": 13.630823714401307, "Epilepsy congenital ": 42.57156213248659, "Epileptic aura ": 15.360029796129202, "Exophthalmos ": 3.328970420079228, "Exposure via breast milk ": 4.812187527077993, "Face injury ": 4.789868505827508, "Feeling drunk ": 3.227438883213051, "Fibroadenoma of breast ": 5.975838529198811, "Flight of ideas ": 9.800274787158592, "Focal dyscognitive seizures ": 58.98607733155528, "Foetal anticonvulsant syndrome ": 3.4285693342522605, "Foetal death ": 2.5248137233410244, "Foetal distress syndrome ": 2.735638230264219, "Foetal exposure during pregnancy ": 2.3197007003555683, "Foetal growth restriction ": 4.650077910988972, "Foetal malformation ": 11.826394744251704, "Foetal malnutrition ": 22.90792089754053, "Food aversion ": 2.1329299066659426, "Food interaction ": 2.5189865058628635, "Frustration tolerance decreased ": 3.2637170954778822, "Gamma-glutamyltransferase increased ": 2.1879518590832103, "Gastrointestinal tube insertion ": 2.255196536636124, "Generalised tonic-clonic seizure ": 22.691509797373524, "Gingival disorder ": 3.96193335203925, "Gingival hypertrophy ": 4.36251703539421, "Gingival recession ": 4.559689343370957, "Gingival swelling ": 3.1867055273932308, "Glioblastoma ": 13.13220802569392, "Glioblastoma multiforme ": 14.24832925259962, "Glioma ": 10.192927219759229, "Growth retardation ": 3.8445530073409455, "Haemangioma ": 2.534742271829902, "Hallucination ": 3.261779059277813, "Hallucination, auditory ": 3.9479046521429058, "Hallucination, visual ": 3.675635395878644, "Head injury ": 3.2505317147597084, "Head titubation ": 4.238065300472702, "Hepatic cytolysis ": 4.685534274243059, "Hepatic failure ": 2.011918240376368, "Hepatitis acute ": 2.148045112461197, "Homicidal ideation ": 3.657188906861641, "Hostility ": 14.146770505240656, "Hyperammonaemia ": 4.216449703602315, "Hypersomnia ": 3.1867114239231267, "Hypertonia ": 3.344390891354098, "Hypoglycaemia neonatal ": 2.972033016891591, "Hypomania ": 2.699385322973444, "Hyponatraemia ": 2.3129990946120937, "Hyponatraemic syndrome ": 6.912856548091505, "Hypospadias ": 4.90260679666417, "Hypothermia ": 3.330552349857597, "Hypotonia ": 2.408479151492726, "Hypotonia neonatal ": 5.599414634373877, "Hypovitaminosis ": 4.322584251932325, "Ileus paralytic ": 2.813218186823406, "Impatience ": 6.789559130478277, "Implant site erosion ": 15.365046518605595, "Implant site extravasation ": 20.610864628454262, "Implant site infection ": 15.953362756460644, "Implant site swelling ": 20.377184296984304, "Impulsive behaviour ": 4.837932344503909, "Inability to afford medication ": 2.144046934425343, "Inappropriate antidiuretic hormone secretion ": 2.8464149906105067, "Induced labour ": 10.985256136668514, "Infantile apnoea ": 3.973170445646228, "Infantile spasms ": 7.414556321326129, "Inhibitory drug interaction ": 3.3930176656304183, "Intellectual disability ": 2.9869003578834934, "Intentional self-injury ": 2.0498707183864022, "Intracranial pressure increased ": 2.690756153867914, "Irritability ": 7.34318230157772, "Jaundice neonatal ": 3.526849387671743, "Language disorder ": 2.3190226428362197, "Large for dates baby ": 4.936848750049724, "Learning disability ": 4.172058735368958, "Learning disorder ": 4.947956250178342, "Lennox-Gastaut syndrome ": 39.79996604871586, "Leukopenia ": 3.10137704014513, "Lip injury ": 3.406737208157162, "Liver function test increased ": 2.1936848038861623, "Logorrhoea ": 3.341601385458941, "Low birth weight baby ": 7.953660196519968, "Low set ears ": 18.53886621780069, "Major depression ": 4.898458763041879, "Maternal exposure before pregnancy ": 14.029717863992246, "Maternal exposure during breast feeding ": 4.968293891651217, "Maternal exposure during pregnancy ": 8.66098384054666, "Medical device site erythema ": 56.36560644688014, "Medical device site fibrosis ": 140.10334883477805, "Memory impairment ": 3.315903651478308, "Meningioma ": 5.428264388703753, "Meningitis bacterial ": 3.8921821733887274, "Mental disorder ": 3.355723460706693, "Mental impairment ": 2.7675201001747585, "Mental status changes ": 2.238745380779076, "Metabolic disorder ": 3.073114908022468, "Metabolic encephalopathy ": 2.760233712987468, "Microcephaly ": 8.783099123555639, "Miosis ": 2.130490878890328, "Mixed anxiety and depressive disorder ": 3.5784708307580257, "Mixed liver injury ": 2.812450387597942, "Mood altered ": 5.5496277945870505, "Mood swings ": 8.014207195521426, "Morbid thoughts ": 8.47177729143926, "Motor developmental delay ": 6.633354691234914, "Multiple congenital abnormalities ": 3.3469187944263923, "Multiple-drug resistance ": 32.05695506524039, "Muscle spasticity ": 2.569772833860457, "Muscle twitching ": 2.3087175839871747, "Mutism ": 5.781697817227845, "Myoclonic epilepsy ": 39.77733889882512, "Myoclonus ": 5.136093523856046, "Nasal pruritus ": 2.2751141661865315, "Negative thoughts ": 4.214585880133037, "Neonatal respiratory distress ": 4.434210431631492, "Neonatal respiratory distress syndrome ": 7.408884349136048, "Nervousness ": 2.534013444914005, "Neurogenic bladder ": 5.055716130057183, "Nonspecific reaction ": 4.064025810870016, "Nose deformity ": 7.3403523726244995, "Nystagmus ": 2.15960321839786, "Obsessive thoughts ": 3.8921821733887274, "Obsessive-compulsive disorder ": 2.485033408505231, "Off label use ": 2.355783776228093, "Optic atrophy ": 4.9864507668882805, "Overdose ": 3.3403727416393214, "Pancytopenia ": 2.967371999404607, "Panic attack ": 2.587018937301792, "Paranoia ": 4.226306789099626, "Partial seizures ": 36.55949668069951, "Partial seizures with secondary generalisation ": 19.223293066564263, "Patent ductus arteriosus ": 4.9851020982742655, "Paternal exposure before pregnancy ": 26.518275989902943, "Perinatal depression ": 9.593312485670609, "Persecutory delusion ": 2.989333532519069, "Perseveration ": 19.181150619546123, "Personality change ": 9.360923562311852, "Personality disorder ": 6.4103180099559705, "Petit mal epilepsy ": 33.76281055809101, "Physical assault ": 7.961523478268476, "Placental disorder ": 5.102457531575547, "Pneumonia aspiration ": 2.742012173483117, "Pneumonia pseudomonal ": 4.458761130232161, "Pneumonia staphylococcal ": 3.931104252029086, "Pneumonitis aspiration ": 4.618967259848595, "Pocket erosion ": 35.78042598318595, "Polydactyly ": 6.870752334737723, "Polyhydramnios ": 3.055436957807088, "Poor feeding infant ": 2.5642801201522647, "Poor sucking reflex ": 10.847342777148116, "Postictal 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2.809785918185543, "Pulmonary valve stenosis ": 3.2678817240477334, "Quadriparesis ": 2.1766144077354044, "Rash maculo-papular ": 2.811049646804213, "Reading disorder ": 2.914259566032516, "Renal aplasia ": 7.226784855403022, "Respiratory acidosis ": 2.0167998514319883, "Respiratory rate decreased ": 2.249677547493772, "Resuscitation ": 3.7383480096237856, "Retrognathia ": 13.164849307692906, "Road traffic accident ": 2.13216943554359, "SARS-CoV-2 test negative ": 2.533607588762712, "Screaming ": 3.908187176926599, "Sedation ": 2.1900639436658604, "Seizure ": 17.915888977898966, "Seizure cluster ": 29.673419533482484, "Self-destructive behaviour ": 8.273992609612744, "Self-injurious ideation ": 3.391359263937669, "Simple partial seizures ": 47.500849804810976, "Skin laceration ": 3.058219787818623, "Sleep deficit ": 2.7782502839505336, "Sleep paralysis ": 5.562104261848378, "Slow response to stimuli ": 2.468516350666987, "Sluggishness ": 2.4203762340102357, "Small for dates baby ": 17.54548811429398, "Social avoidant behaviour ": 3.247288359744438, "Somnolence ": 4.439646969167794, "Sopor ": 4.538474149662102, "Speech disorder ": 3.465666319965071, "Speech disorder developmental ": 2.3775963747562257, "Spina bifida ": 4.085662797612101, "Staphylococcus test positive ": 2.7917286286653487, "Staring ": 7.0045545483767615, "Status epilepticus ": 32.693094686613975, "Stevens-Johnson syndrome ": 5.127180131332464, "Stillbirth ": 2.357729955872664, "Stupor ": 3.6237758844165184, "Substance-induced psychotic disorder ": 2.04871700727991, "Sudden death ": 2.789158769405959, "Sudden unexplained death in epilepsy ": 42.73296686299671, "Suicidal behaviour ": 11.176884936208932, "Suicidal ideation ": 7.095066590535667, "Suicide attempt ": 5.602345788795961, "Systemic infection ": 6.314935411712529, "Systolic hypertension ": 4.126278649887807, "Talipes ": 4.36565914847678, "Temporal lobe epilepsy ": 8.620988439107695, "Teratogenicity ": 35.01663438497142, "Tethered oral tissue ": 12.179153752324716, "Therapeutic product ineffective ": 5.1164702389122825, "Therapy change ": 2.485814916004861, "Therapy interrupted ": 4.179171954744983, "Thinking abnormal ": 3.1135010999094326, "Thrombocytopenia ": 2.982124886432985, "Tic ": 2.48019282059977, "Tongue biting ": 6.8674473329428585, "Tongue injury ": 5.632142380002036, "Tonic convulsion ": 9.583248395021304, "Tooth disorder ": 2.2524269849908403, "Toxic encephalopathy ": 3.4918725130635884, "Toxic epidermal necrolysis ": 5.796241590630328, "Toxic skin eruption ": 2.3288348507470675, "Transaminases increased ": 2.2027551678154618, "Treatment noncompliance ": 3.0218563449361526, "Tumour excision ": 6.791161402033722, "Twin pregnancy ": 24.062238392646528, "Umbilical cord abnormality ": 8.881756108754143, "Umbilical hernia ": 2.111714174555979, "Unevaluable event ": 3.6788389546728366, "Unintended pregnancy ": 9.379003548344048, "Urinary incontinence ": 2.041263588073656, "Urine output increased ": 2.7640426517708674, "Vagal nerve stimulator implantation ": 109.90293221953046, "Ventricular septal defect ": 3.4774512030482283, "Volvulus ": 2.833147889592419, "Walking disability ": 2.008718277515829, "Weight gain poor ": 3.042301605675384, "Wound dehiscence ": 7.564837726083727, "Wound infection staphylococcal ": 7.835741715524683, "Wrong dose ": 6.753798690662763, "Wrong patient ": 15.54106441075508, "Wrong patient received product ": 6.924782833735076, "Wrong product administered ": 2.177022848707355, "Wrong technique in product usage process ": 2.191300379341916} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/622.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/622.json new file mode 100644 index 00000000000..235a2ea1124 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/622.json @@ -0,0 +1 @@ +{"Hyperkalaemia ": 100.97790017031684} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/623.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/623.json new file mode 100644 index 00000000000..b9cea76ed4b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/623.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 2.745017414611656, "Acne ": 3.275654601448426, "Alopecia ": 2.168174005122785, "B-lymphocyte count decreased ": 284.462427783172, "Blood immunoglobulin G decreased ": 47.53312550050819, "Blood immunoglobulin M decreased ": 222.44735195869603, "Body temperature increased ": 4.055517813646709, "Brain fog ": 2.0216948139048894, "Breast cancer ": 2.3297094260879407, "Bronchitis ": 2.347188477899661, "Central nervous system lesion ": 14.729543421403823, "Coronavirus infection ": 38.14334658421333, "Cystitis noninfective ": 32.19185824680456, "Disease recurrence ": 4.121766049866988, "Gait disturbance ": 3.7844230336159583, "Hemiparesis ": 4.338213268122822, "Hypoaesthesia ": 2.9636502819010446, "Incorrect dose administered by device ": 8.448579496906097, "Infection ": 3.3217266954155638, "Influenza ": 2.7477400831620264, "Influenza like illness ": 6.522479623162985, "Injection related reaction ": 41.89252635681664, "Injection site haemorrhage ": 5.423620175613192, "Listless ": 4.753311765503098, "Liver function test increased ": 2.489360719050035, "Lymphocyte count decreased ": 29.657195624357826, "Lymphopenia ": 9.54347259262302, "Maternal exposure during breast feeding ": 4.468809395352782, "Multiple sclerosis ": 50.33137836897392, "Multiple sclerosis relapse ": 86.02330080684595, "Muscle spasticity ": 8.929703806074848, "Muscular weakness ": 2.325459609638912, "Nasopharyngitis ": 8.46147952859894, "Optic neuritis ": 10.21881080861654, "Oral herpes ": 9.870295650029282, "Oropharyngeal pain ": 3.124306366718031, "Paralysis ": 2.623151903764049, "Relapsing-remitting multiple sclerosis ": 141.534833756436, "Respiratory tract infection ": 3.871728013760523, "Rhinorrhoea ": 3.2106796698796525, "SARS-CoV-2 test positive ": 5.556937183258048, "Secondary progressive multiple sclerosis ": 100.80460411597666, "Sensory disturbance ": 3.839782968214692, "Throat irritation ": 2.211219098823108, "Upper respiratory tract infection ": 2.434798065387689, "Urinary tract infection ": 3.3011410479889527} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/624.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/624.json new file mode 100644 index 00000000000..4437aba1078 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/624.json @@ -0,0 +1 @@ +{"Off label use ": 9.39940867107983} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/625.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/625.json new file mode 100644 index 00000000000..abffcb273c5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/625.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 4.355758747178736, "Aspartate aminotransferase increased ": 5.515641905804967, "Chromaturia ": 14.048979455581048, "Drug interaction ": 4.77327077947787, "Drug-induced liver injury ": 7.214618868755462, "Hepatic enzyme increased ": 4.112390649915261, "International normalised ratio increased ": 14.554849425650922, "Jaundice ": 13.372204526990384} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/626.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/626.json new file mode 100644 index 00000000000..ff11c906395 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/626.json @@ -0,0 +1 @@ +{"Abdominal distension ": 3.0062006333038283, "Bladder dilatation ": 199.8597747404807, "Blood pressure increased ": 2.813878334244332, "Constipation ": 2.058027656312107, "Disease progression ": 4.512879104731893, "Drug interaction ": 5.277654561802356, "Electrocardiogram QT prolonged ": 4.789970606935725, "Heart rate increased ": 2.483794224687885, "Hypersensitivity ": 2.6482454269344577, "Hypertonia ": 29.58478134540618, "Muscle tightness ": 16.48986926511455, "Musculoskeletal stiffness ": 2.535045555170216, "Oedema peripheral ": 2.753608157937103, "Performance status decreased ": 30.796717521955948, "Respiratory distress ": 5.883485711525176, "Restlessness ": 4.638903363901665, "Subcutaneous abscess ": 74.53458561849743, "Therapy non-responder ": 12.926076507049508, "Urinary incontinence ": 9.487403754425392, "Urinary retention ": 4.849656710869163} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/627.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/627.json new file mode 100644 index 00000000000..483cb54ba9f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/627.json @@ -0,0 +1 @@ +{"Joint swelling ": 6.192097503644567, "Pain ": 2.0493777191454114, "Rheumatoid arthritis ": 11.631571390001218} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/628.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/628.json new file mode 100644 index 00000000000..1a9f59e68ff --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/628.json @@ -0,0 +1 @@ +{"Acute interstitial pneumonitis ": 5.986093193155452, "Acute polyneuropathy ": 5.4238229641812215, "Addison's disease ": 6.864005961426807, "Administration site extravasation ": 2.96330430968245, "Adrenal disorder ": 37.40681010923286, "Adrenal insufficiency ": 49.96298620275996, "Adrenocortical insufficiency acute ": 16.494137195926907, "Adrenocorticotropic hormone deficiency ": 104.73329088046238, "Adverse event ": 12.327030749376284, "Alanine aminotransferase abnormal ": 2.0485290694181604, "Amylase increased ": 4.406406651186828, "Aortic arteriosclerosis ": 2.50238390549157, "Aortitis ": 3.1345859926033364, "Ascites ": 2.281882678551992, "Aspartate aminotransferase abnormal ": 4.52972881642863, "Atelectasis ": 2.748518175538805, "Atrioventricular block complete ": 2.070409462788072, "Autoimmune arthritis ": 32.68431358077445, "Autoimmune colitis ": 37.19573488581798, "Autoimmune haemolytic anaemia ": 6.385468127553972, "Autoimmune hepatitis ": 14.567744735764007, "Autoimmune hypothyroidism ": 47.03496572746179, "Autoimmune lung disease ": 45.09458878332744, "Autoimmune myocarditis ": 71.32749894264413, "Autoimmune myositis ": 26.657440097987852, "Autoimmune nephritis ": 31.257978707578943, "Autoimmune pancreatitis ": 37.87823796219618, "Autoimmune thyroiditis ": 7.63963445084951, "Bladder tamponade ": 9.258182270334702, "Blood albumin decreased ": 2.271197452634864, "Blood alkaline phosphatase abnormal ": 5.584455930761068, "Blood bilirubin abnormal ": 3.345762585899509, "Blood corticotrophin abnormal ": 23.02016556257564, "Blood corticotrophin decreased ": 32.04578747602121, "Blood corticotrophin increased ": 31.93314759589543, "Blood creatine phosphokinase MB increased ": 2.0888918106477794, "Blood creatinine abnormal ": 3.534098452022449, "Blood creatinine decreased ": 2.8285443080813675, "Blood sodium decreased ": 2.344088799512093, "Blood thyroid stimulating hormone abnormal ": 9.8089966110222, "Blood thyroid stimulating hormone decreased ": 11.616221908715366, "Blood thyroid stimulating hormone increased ": 13.781833974038578, "Brain natriuretic peptide increased ": 2.249382105954308, "Brain oedema ": 2.316992445120237, "Breast conserving surgery ": 2.521082005800652, "C-reactive protein increased ": 2.1702735520472367, "Cancer pain ": 12.034035360388511, "Cancer surgery ": 11.258138919158805, "Capillary leak syndrome ": 2.565222654944036, "Carbohydrate antigen 125 increased ": 2.618172139112985, "Carcinoembryonic antigen increased ": 3.885256603698326, "Cardiac dysfunction ": 4.289649672982359, "Cardiac failure acute ": 2.6857047442167103, "Cardiac tamponade ": 7.992568934778222, "Cardiomyopathy ": 2.022878837981948, "Central hypothyroidism ": 15.649534076048342, "Central venous catheterisation ": 5.071598737092821, "Cerebral infarction ": 2.0160098101912625, "Cheilitis ": 2.051553465820028, "Chemotherapy ": 5.387021727562197, "Cholangitis ": 12.698949945278873, "Cholangitis acute ": 4.793585514195206, "Cholangitis sclerosing ": 59.75649593900794, "Cholecystitis ": 5.822201377567525, "Cholecystitis acute ": 5.795574039374032, "Cholestatic liver injury ": 2.39679459204543, "Chronic gastritis ": 2.1285606587851618, "Colitis ": 13.857553310810966, "Colitis microscopic ": 3.859972766733129, "Coronavirus infection ": 3.4957323234854005, "Cortisol abnormal ": 22.80020933166875, "Cortisol decreased ": 17.021529919785316, "Cortisol increased ": 8.853931365442943, "Cutaneous sarcoidosis ": 5.051036220137024, "Cutaneous symptom ": 3.743584237369833, "Cytokine release syndrome ": 2.5720906417111187, "Cytokine storm ": 13.275921568041484, "Cytomegalovirus enterocolitis ": 6.346603054590008, "Cytopenia ": 2.2119957267416464, "Death ": 2.976692462106675, "Decreased appetite ": 2.7461583638884446, "Demyelinating polyneuropathy ": 2.563656516047594, "Dermatitis ": 2.1926421512042102, "Dermatitis psoriasiform ": 7.074087587074197, "Dermatomyositis ": 8.577190348460954, "Device related infection ": 2.6907005772513277, "Diabetes mellitus ": 2.0431317467690926, "Diabetic ketoacidosis ": 3.359984543708683, "Diabetic ketosis ": 3.270607604992777, "Disseminated intravascular coagulation ": 3.681532476172509, "Drug effective for unapproved indication ": 4.97084235701894, "Drug eruption ": 2.7352618133793123, "Drug-induced liver injury ": 2.516915528125013, "Duodenal perforation ": 9.332664121602413, "Duodenal ulcer ": 2.4980881873720278, "Duodenitis ": 2.7261153521413832, "Dysphonia ": 4.051278935993192, "Eastern Cooperative Oncology Group performance status worsened ": 56.974580259183725, "Electrolyte imbalance ": 2.2885065396374, "Encephalitis ": 11.088557889798532, "Encephalitis autoimmune ": 18.750836167847023, "Endocrine disorder ": 9.525666289731902, "Enteritis ": 4.845658164072351, "Enteritis infectious ": 3.897667219372453, "Enterocolitis ": 16.608466108090273, "Enterocolitis haemorrhagic ": 2.117151703327928, "Eosinophil count increased ": 2.956941509458654, "Eosinophil percentage increased ": 6.68440829051359, "Eosinophilic fasciitis ": 13.065277410112246, "Erythema multiforme ": 4.452583286113089, "Eyelid ptosis ": 6.523114892462552, "Febrile bone marrow aplasia ": 4.057783651184814, "Febrile neutropenia ": 2.807997715164142, "Feeding disorder ": 2.406936131048468, "Female genital tract fistula ": 2.490971027051593, "Fistula ": 4.291905273152781, "Fulminant type 1 diabetes mellitus ": 117.9888966304432, "Gallbladder enlargement ": 2.3227715616830014, "Gamma-glutamyltransferase abnormal ": 4.863213612616732, "Gastric perforation ": 3.3627702920868128, "Gastrointestinal oedema ": 4.802839406130677, "Gastrointestinal perforation ": 10.0352383419167, "Gingivitis ": 2.084523558275569, "Glomerulonephritis membranous ": 3.1839275060083363, "Glomerulonephritis rapidly progressive ": 5.415055326807208, "Glucocorticoid deficiency ": 29.36680594561123, "Graves' disease ": 2.151061098207687, "Guillain-Barre syndrome ": 3.1850342270855, "Haemoglobin abnormal ": 4.1613202131235205, "Haemophagocytic lymphohistiocytosis ": 8.293491465441878, "Hepatic cytolysis ": 2.5013597715836724, "Hepatic function abnormal ": 4.693811020261388, "Hepatitis ": 6.661492202102698, "Hepatitis fulminant ": 2.54644489409303, "Hepatotoxicity ": 2.220964745199124, "Hospice care ": 11.291359779707475, "Hydronephrosis ": 4.033803880570942, "Hyperamylasaemia ": 4.407642154162958, "Hyperlipasaemia ": 3.0402100128312384, "Hypertension ": 3.8392457430556126, "Hyperthyroidism ": 16.505104565147377, "Hypertransaminasaemia ": 2.3286141971596277, "Hypoalbuminaemia ": 3.170103430007354, "Hypophysitis ": 39.63832308174628, "Hypopituitarism ": 53.13344385945798, "Hypothalamo-pituitary disorder ": 33.390427184058176, "Hypothyroidism ": 32.01013841738435, "Ileus ": 3.3916147041408395, "Immune thrombocytopenia ": 5.553047716682348, "Immune-mediated adrenal insufficiency ": 259.568585301724, "Immune-mediated adverse reaction ": 106.5273546054814, "Immune-mediated arthritis ": 134.24104214351402, "Immune-mediated cholangitis ": 360.8979806337396, "Immune-mediated cystitis ": 82.35272280888942, "Immune-mediated dermatitis ": 93.16676723494518, "Immune-mediated encephalitis ": 105.58729924737008, "Immune-mediated endocrinopathy ": 88.82862638785676, "Immune-mediated enterocolitis ": 138.07732784991654, "Immune-mediated gastritis ": 108.8962407920274, "Immune-mediated hepatic disorder ": 191.11539641465163, "Immune-mediated hepatitis ": 87.41113155200065, "Immune-mediated hyperthyroidism ": 323.0698645750154, "Immune-mediated hypophysitis ": 42.81127338715039, "Immune-mediated hypothyroidism ": 420.7737835460768, "Immune-mediated lung disease ": 117.05357930986636, "Immune-mediated myasthenia gravis ": 160.6908292634454, "Immune-mediated myocarditis ": 126.54803606564856, "Immune-mediated myositis ": 84.43892864911557, "Immune-mediated nephritis ": 82.38576537543292, "Immune-mediated neurological disorder ": 71.57359804206126, "Immune-mediated neuropathy ": 42.0542566595739, "Immune-mediated pancreatitis ": 175.430043451578, "Immune-mediated pancytopenia ": 86.4566241693717, "Immune-mediated pericarditis ": 128.7659776574867, "Immune-mediated renal disorder ": 231.1922072947446, "Immune-mediated thyroiditis ": 61.85443684482134, "Immune-mediated uveitis ": 130.0459572587717, "Inability to afford medication ": 2.4229405796487637, "Inappropriate antidiuretic hormone secretion ": 2.023099702122953, "Inappropriate schedule of product administration ": 3.30449519163866, "Infectious pleural effusion ": 5.131562851067691, "Infusion site extravasation ": 2.272790940798313, "Interstitial lung disease ": 20.56373056633357, "Intestinal fistula ": 8.197828217190049, "Intestinal perforation ": 5.594446422647323, "Intra-abdominal fluid collection ": 3.8889013239885006, "KL-6 increased ": 25.46344956280277, "Keratitis ": 2.243657324371274, "Large intestinal haemorrhage ": 2.120051534269944, "Large intestine perforation ": 4.593060433584121, "Leukoderma ": 25.213205145039304, "Lichen planus ": 8.401622223797961, "Lichenoid keratosis ": 12.91858344233929, "Lipase increased ": 2.234355698926608, "Liver disorder ": 3.477080683953705, "Loss of therapeutic response ": 2.2156208566144664, "Lung abscess ": 4.36313853510541, "Lung carcinoma cell type unspecified recurrent ": 6.749403110579432, "Lung consolidation ": 2.347257090521638, "Lung disorder ": 3.4140526984933017, "Lung opacity ": 7.0467050434274965, "Lymphadenectomy ": 10.28222482606338, "Lymphadenopathy mediastinal ": 3.961273557154689, "Lymphangiosis carcinomatosa ": 17.71982293759872, "Lymphocytic hypophysitis ": 15.2176430654473, "Malignant ascites ": 15.44114488723946, "Malignant gastrointestinal obstruction ": 40.06616746239568, "Malignant neoplasm oligoprogression ": 42.14701765866408, "Malignant neoplasm progression ": 34.96939152703957, "Malignant pleural effusion ": 16.60076339480707, "Mastectomy ": 3.403633801052591, "Mean cell haemoglobin increased ": 3.238949866378964, "Melanoma recurrent ": 19.4419816727237, "Meningitis ": 4.869034976549676, "Meningitis aseptic ": 2.462047793821412, "Metastases to meninges ": 3.709840129301144, "Metastatic malignant melanoma ": 2.898609733216808, "Mixed liver injury ": 2.315381878790771, "Mucosal inflammation ": 2.7287166109150296, "Myasthenia gravis ": 29.305083589509465, "Myasthenia gravis crisis ": 9.84488804159934, "Myasthenic syndrome ": 15.890342360489829, "Myelosuppression ": 2.060662072085421, "Myocardial necrosis marker increased ": 3.077639447265126, "Myocarditis ": 6.149165904754061, "Myositis ": 20.54695776918828, "Necrotising fasciitis ": 2.362435914068973, "Necrotising myositis ": 15.268277178365915, "Nephritis ": 33.22766256792849, "Nephrotic syndrome ": 3.1504359303777854, "Neuromyopathy ": 2.317973310484395, "Neuropathy peripheral ": 2.544813082403208, "Neutrophil count decreased ": 2.842167648314213, "Non-small cell lung cancer recurrent ": 16.987094632975086, "Nutritional condition abnormal ": 5.223122764657142, "Ocular myasthenia ": 11.793309206194769, "Oesophageal perforation ": 6.376720843017223, "Oesophageal stenosis ": 3.139119323043714, "Ophthalmoplegia ": 2.5570750976371146, "Optic neuritis ": 3.257634972181272, "Oral mucosa erosion ": 2.8422271894390527, "Organising pneumonia ": 15.58186271957175, "Oxygen saturation abnormal ": 3.268273782571876, "Oxygen therapy ": 4.168712712046613, "Palliative care ": 6.598997586342115, "Palmar-plantar erythrodysaesthesia syndrome ": 8.739637151379464, "Pancreatic enzymes increased ": 2.742036346706606, "Pancreatic failure ": 3.436255674831981, "Paraneoplastic syndrome ": 12.313563280528632, "Pathological fracture ": 2.0494406788511426, "Pemphigoid ": 13.813117370311137, "Perforation ": 8.080314761591087, "Pericardial effusion ": 3.4181474689127325, "Pericarditis malignant ": 96.00996264380446, "Physical deconditioning ": 3.0615832036279764, "Platelet count decreased ": 4.407596357491915, "Pleural effusion ": 3.7989200562171, "Pneumatosis intestinalis ": 3.6030559072700488, "Pneumocystis jirovecii pneumonia ": 4.056222237555544, "Pneumonia ": 2.1587068689823843, "Pneumonia aspiration ": 3.5323653893658764, "Pneumonia bacterial ": 9.303075547112124, "Pneumonitis ": 23.006069446903247, "Pneumothorax ": 4.381583129605632, "Polyarthritis ": 6.085150867459725, "Polymyalgia rheumatica ": 6.824011134335908, "Polymyositis ": 8.695467953802197, "Posterior reversible encephalopathy syndrome ": 2.826861594893625, "Postrenal failure ": 11.618461616540635, "Prerenal failure ": 5.650137096600775, "Primary adrenal insufficiency ": 18.042906794702397, "Primary hypothyroidism ": 14.76351931431538, "Procalcitonin increased ": 4.277540214792153, "Product use in unapproved indication ": 5.99283082521169, "Product use issue ": 2.923306400686949, "Protein urine ": 13.279910423362985, "Protein urine present ": 3.671743505746551, "Proteinuria ": 13.234297614067325, "Psoas abscess ": 4.578429259945913, "Pulmonary sarcoidosis ": 6.525933753424509, "Pulmonary toxicity ": 9.431170679849703, "Pyelonephritis ": 2.826087413081574, "Radiation injury ": 6.785455178615529, "Radiation pneumonitis ": 32.071035686315774, "Radiotherapy ": 21.86230494983322, "Rectal perforation ": 10.672991937282085, "Recurrent cancer ": 8.020456064420685, "Red blood cell count abnormal ": 3.739268058052948, "Red blood cell count increased ": 2.200138244218991, "Red blood cell transfusion ": 4.160238052556816, "Renal impairment ": 3.271374438672857, "Renal tubular acidosis ": 2.5978217374799946, "Respiratory failure ": 2.0185431064724373, "Retroperitoneal fibrosis ": 5.475377659097775, "Rheumatic disorder ": 2.151300969877792, "Salivary hyposecretion ": 4.113975646860011, "Sarcoidosis ": 4.18336099069734, "Secondary adrenocortical insufficiency ": 34.77683289321213, "Septic shock ": 2.7713121369408737, "Seronegative arthritis ": 3.897667219372453, "Sialoadenitis ": 6.638637429754011, "Silent thyroiditis ": 63.60152730447131, "Sjogren's syndrome ": 6.088956732040036, "Skin disorder ": 3.933132847427425, "Skin toxicity ": 6.805813742651205, "Small intestinal haemorrhage ": 2.941486796233526, "Small intestinal perforation ": 20.730919977985277, "Stevens-Johnson syndrome ": 3.947256634557669, "Stomatitis ": 4.168139959605727, "Stress cardiomyopathy ": 3.0530301926649046, "Subacute cutaneous lupus erythematosus ": 3.047388383134796, "Superior vena cava syndrome ": 5.811532128127838, "Therapeutic response increased ": 2.296364519186749, "Therapy partial responder ": 15.82749299302865, "Thrombophlebitis migrans ": 46.02028782073444, "Thyroid disorder ": 11.239268356469314, "Thyroid function test abnormal ": 5.692708112050763, "Thyroid hormones decreased ": 14.120365693186525, "Thyroid hormones increased ": 8.041315214246424, "Thyroiditis ": 39.6958368585039, "Thyroiditis subacute ": 2.6349511871933253, "Thyrotoxic crisis ": 9.139962402598456, "Thyroxine free decreased ": 5.201735905959504, "Thyroxine free increased ": 6.18934622980978, "Toxic epidermal necrolysis ": 3.443885010688703, "Transfusion ": 2.2354890584980778, "Tri-iodothyronine free decreased ": 18.204563809112955, "Tri-iodothyronine free increased ": 18.72279381698133, "Troponin I increased ": 2.9124180961415327, "Troponin T increased ": 3.580713761794635, "Troponin increased ": 4.445853439112568, "Tubulointerstitial nephritis ": 10.747953288241854, "Tumour associated fever ": 51.060604991998346, "Tumour haemorrhage ": 7.391718511988311, "Tumour hyperprogression ": 100.93320344107418, "Tumour lysis syndrome ": 3.0199734313850017, "Tumour marker increased ": 3.551644976559348, "Tumour necrosis ": 15.667133427577475, "Tumour pain ": 6.876141952934418, "Tumour pseudoprogression ": 81.37858774211624, "Type 1 diabetes mellitus ": 34.41108926411956, "Urogenital fistula ": 37.388884063769616, "Uveitis ": 4.246183516964763, "Vitiligo ": 19.69859570869667, "Vocal cord paralysis ": 2.095050262815306, "Vogt-Koyanagi-Harada disease ": 9.601844134459114, "Warm autoimmune haemolytic anaemia ": 14.567657279620676} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/629.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/629.json new file mode 100644 index 00000000000..1f56acaff55 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/629.json @@ -0,0 +1 @@ +{"Agranulocytosis ": 15.808854883498803, "Condition aggravated ": 4.394074219096827, "Liver injury ": 21.972363966381543, "Off label use ": 3.66364198865929} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/63.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/63.json new file mode 100644 index 00000000000..c16b5e37649 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/63.json @@ -0,0 +1 @@ +{"Ascites ": 3.427845662302708, "Bedridden ": 7.034340330039236, "Blood pressure abnormal ": 5.730729404650674, "Brain natriuretic peptide increased ": 25.95471323723197, "Cardiac arrest ": 2.0899313990081123, "Cardiac disorder ": 2.335791926300617, "Cardiac failure ": 4.728276824691063, "Cardiac failure congestive ": 3.3151349492650053, "Catheter site discharge ": 103.27590703428268, "Cellulitis ": 8.144903209767634, "Crepitations ": 76.48666038426065, "Device occlusion ": 17.347753591515986, "Dizziness exertional ": 209.7620579019165, "Dyspnoea ": 2.7037390777486, "Dyspnoea exertional ": 7.761725619343239, "Epistaxis ": 3.0098741339023487, "Feeding disorder ": 6.791424561786785, "Feeling abnormal ": 2.374010380050143, "Fluid retention ": 15.685837016848804, "Flushing ": 6.205495925250792, "Gastroenteritis viral ": 20.69488058713773, "Haemoptysis ": 3.306428790812638, "Hospitalisation ": 2.973524653144432, "Hypervolaemia ": 17.603873303054794, "Hypoacusis ": 2.7916473154467707, "Hypotension ": 2.117238389579711, "Hypoxia ": 3.4917185393993955, "Ill-defined disorder ": 3.788780259867505, "Illness ": 2.336109502701676, "Infective exacerbation of chronic obstructive airways disease ": 479.62612411042807, "Iron deficiency anaemia ": 16.06189173093725, "Memory impairment ": 2.550416963317032, "Nasal congestion ": 8.602002550380435, "Oedema ": 4.846218519886903, "Oedema peripheral ": 5.576157889574819, "Oxygen saturation decreased ": 3.533498342552415, "Pain in jaw ": 20.35193601894708, "Pericardial effusion ": 4.064654600447698, "Peripheral swelling ": 2.21963515297341, "Premature delivery ": 6.1744054254780325, "Productive cough ": 10.476618575923926, "Pulmonary arterial hypertension ": 31.80249356509378, "Pulmonary hypertension ": 23.393007946377143, "Pulmonary oedema ": 2.9655075655627914, "Right ventricular failure ": 55.299270670161874, "Skin discolouration ": 2.4693956830556747, "Transfusion ": 10.481514586680497, "Unevaluable event ": 7.399869150646448, "Vascular device infection ": 34.23346945907328, "Vitamin D decreased ": 24.229767969928343, "Weight decreased ": 2.920628145350486, "Weight increased ": 3.97229738675915, "Wheezing ": 2.1237616544143507} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/630.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/630.json new file mode 100644 index 00000000000..3d1b7cbc0ca --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/630.json @@ -0,0 +1 @@ +{"Cough ": 5.544821491995517} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/631.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/631.json new file mode 100644 index 00000000000..6a5c9af970a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/631.json @@ -0,0 +1 @@ +{"Dyspnoea ": 2.164032281173917} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/632.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/632.json new file mode 100644 index 00000000000..e4d90e870bc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/632.json @@ -0,0 +1 @@ +{"Anaphylactic reaction ": 5.221294284930504, "Anaphylactic shock ": 3.8399960865024623, "Anaphylactoid reaction ": 17.596572886453956, "Back pain ": 3.731648370017065, "Blood pressure increased ": 3.046015383938677, "Body temperature increased ": 5.35426907012695, "Bronchospasm ": 3.6483714107038696, "Chest discomfort ": 2.290970881067411, "Chills ": 4.4110875423212565, "Cyanosis ": 11.3570530146945, "Drug intolerance ": 3.006177503677002, "Dyspnoea ": 2.3310153714229425, "Erythema ": 2.8047878372077237, "Exposure during pregnancy ": 4.758072862278105, "Feeling cold ": 3.387153975982057, "Flushing ": 5.503629325473761, "Foetal exposure during pregnancy ": 2.153870562547876, "Haemolysis ": 40.068465592741504, "Haemolytic anaemia ": 15.936833509753832, "Hepatitis B core antibody positive ": 119.908424629118, "Hypersensitivity ": 3.9186072475493634, "Hypertension ": 2.829039417747619, "Hyperthermia ": 15.947944483501754, "Hypotension ": 2.3293045649874595, "Hypoxia ": 2.669461542959915, "Infusion related reaction ": 6.4666658005341136, "Livedo reticularis ": 60.54969248978288, "Meningitis ": 12.883176172319638, "Meningitis aseptic ": 120.66271390629689, "Oxygen saturation decreased ": 8.142419989866568, "Pallor ": 3.765455318282479, "Peripheral coldness ": 3.158261590466468, "Photophobia ": 2.932849149058149, "Premature baby ": 3.379669654386116, "Premature delivery ": 5.436984145381256, "Respiratory distress ": 3.415195640407385, "Tachycardia ": 4.515838472941581, "Tachypnoea ": 6.077481772494963, "Tremor ": 3.2911689158927584, "Urticaria ": 2.775070812125989, "Vomiting ": 2.1006608148745363} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/633.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/633.json new file mode 100644 index 00000000000..84ccc4b962a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/633.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 8.697353359952956, "Alopecia ": 3.0801741479401343, "Anaemia ": 2.0365977363857657, "Aphthous ulcer ": 2.5346160377874063, "Aspartate aminotransferase increased ": 9.53093687269678, "Autoimmune hepatitis ": 4.662140448474119, "Blood alkaline phosphatase increased ": 3.525878313786228, "Blood bilirubin increased ": 5.722674809795118, "Blood creatinine increased ": 2.1884418505127563, "Blood test abnormal ": 3.143046533979188, "Bone pain ": 2.0384641392787737, "Breast cancer ": 12.82799912393435, "Breast cancer metastatic ": 49.261672259770044, "Breast cancer recurrent ": 21.115083688579197, "Breast mass ": 5.230897797688006, "Carbohydrate antigen 15-3 increased ": 43.474940418134246, "Carcinoembryonic antigen increased ": 16.59629328567184, "Cell death ": 11.223199500063604, "Decreased immune responsiveness ": 22.14361000558108, "Disease progression ": 3.0846933067524125, "Dry skin ": 6.189108316200277, "Eating disorder ": 2.374733127119992, "Electrocardiogram QT prolonged ": 34.01419135788273, "Gamma-glutamyltransferase increased ": 4.02842079859986, "Gastritis ": 2.2851938233121345, "Glomerular filtration rate decreased ": 2.372394845257269, "Granulocytopenia ": 3.364686094082049, "Haematocrit decreased ": 5.334721197358444, "Haematotoxicity ": 9.52389482859843, "Haemoglobin decreased ": 2.735794503153165, "Hepatic cytolysis ": 8.661838990026082, "Hepatic enzyme increased ": 5.272050677932922, "Hepatic lesion ": 8.380137348698895, "Hepatitis ": 3.111126885078716, "Hepatitis acute ": 3.785607562912243, "Hepatocellular injury ": 3.399987723554554, "Hepatotoxicity ": 31.71551463656383, "Hormone receptor positive HER2 negative breast cancer ": 127.9005657796427, "Hypertransaminasaemia ": 18.154727766307488, "Hypocalcaemia ": 2.4715232658730213, "Immunodeficiency ": 2.7072478251412746, "Jaundice ": 2.493529651810884, "Laboratory test abnormal ": 3.828933922779064, "Lacrimation increased ": 4.072918278244662, "Leukopenia ": 10.860752295209371, "Liver function test abnormal ": 4.145631872372797, "Liver function test increased ": 15.37090083488622, "Lymphocyte count decreased ": 4.53511348170126, "Madarosis ": 18.426697040160583, "Malignant neoplasm progression ": 11.123173098770913, "Metastases to bone ": 37.6961749525868, "Metastases to central nervous system ": 6.32742206755942, "Metastases to liver ": 15.010978097019722, "Metastases to lung ": 16.481581218461102, "Metastases to lymph nodes ": 10.127196207173396, "Metastases to spine ": 35.82018120446954, "Metastasis ": 26.336611257910043, "Mucosal inflammation ": 2.0309088798652577, "Neoplasm ": 4.562013437372067, "Neutropenia ": 31.284378028615265, "Neutrophil count abnormal ": 14.151957148948668, "Neutrophil count decreased ": 6.248092525057419, "Pancytopenia ": 2.684617507136792, "Pigmentation disorder ": 5.251146733616541, "Pleural effusion ": 3.0428501860148667, "Pneumonitis ": 10.406482214027596, "Pulmonary mass ": 2.3870699690185435, "Red blood cell count decreased ": 2.487172250706836, "Second primary malignancy ": 4.840285452898643, "Skin exfoliation ": 3.8624027475706058, "Skin reaction ": 2.3447665588577515, "Skin toxicity ": 7.609922004740166, "Spinal pain ": 3.1869202919652992, "Therapy partial responder ": 7.451667199649868, "Thrombocytopenia ": 2.142224000450723, "Transaminases increased ": 10.33776487715143, "Tumour marker increased ": 25.20782291049756, "Vitiligo ": 35.761569876368, "White blood cell count decreased ": 5.314712591094712} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/634.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/634.json new file mode 100644 index 00000000000..7baab054649 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/634.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 8.495009555188792, "Blood bilirubin increased ": 3.808926616883882, "Blood creatinine increased ": 2.252735372748044, "Cholelithiasis ": 7.463124612674903, "Drug reaction with eosinophilia and systemic symptoms ": 4.263325949771924, "Eosinophilia ": 5.088487823700116, "Exposure during pregnancy ": 6.178409151584386, "Faecaloma ": 34.57568742409237, "Foetal exposure during pregnancy ": 4.451475981750538, "Foetal growth restriction ": 30.626395538135064, "Gamma-glutamyltransferase increased ": 4.525833059178416, "Gastrointestinal disorder ": 2.9624545263051005, "Hepatic cytolysis ": 11.390235639115737, "Hepatitis ": 4.221094782526648, "Hyperbilirubinaemia ": 18.051900573636303, "Jaundice ": 6.632792584050142, "Live birth ": 28.074936511916107, "Myocardial infarction ": 3.8757845799855386, "Nephrolithiasis ": 13.422247823597411, "Osteoarthritis ": 4.465408946100279, "Osteoporosis ": 2.5657577985167404, "Pancreatitis acute ": 3.981455186552933, "Rash maculo-papular ": 2.5458236966590846, "Renal colic ": 40.01624325571736, "Sleep disorder ": 2.7056596780610738, "Toxic epidermal necrolysis ": 7.03745897433159, "Transaminases increased ": 8.521558591341996, "Tubulointerstitial nephritis ": 13.321725348363682} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/635.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/635.json new file mode 100644 index 00000000000..716832f7036 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/635.json @@ -0,0 +1 @@ +{"Anti factor VIII antibody positive ": 3799.027533412679, "Anti factor VIII antibody test ": 4233.530740644854, "Drug specific antibody ": 316.4478466455078, "Factor VIII inhibition ": 2221.579916647552, "Haemarthrosis ": 316.6545819566622, "Haemorrhage ": 41.95756806455338, "Inhibiting antibodies ": 5583.317080444805} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/636.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/636.json new file mode 100644 index 00000000000..ae71afe0abc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/636.json @@ -0,0 +1 @@ +{"Blister ": 74.64098888771214, "Genital erosion ": 10901.437672281838, "Mucosal erosion ": 3914.518092932005, "Rash ": 10.878251681665288, "Stevens-Johnson syndrome ": 241.22462686802143, "Toxic epidermal necrolysis ": 240.08497729088683} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/637.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/637.json new file mode 100644 index 00000000000..9f6d685b982 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/637.json @@ -0,0 +1 @@ +{"Anti factor VIII antibody positive ": 1329.062886870339, "Contusion ": 7.802982581547032, "Epistaxis ": 5.478776902851115, "Fall ": 3.630810348530372, "Haemarthrosis ": 1441.2948583006842, "Haemorrhage ": 103.14428869768828, "Joint injury ": 67.81377526866912, "Joint swelling ": 4.475144717503885, "Limb injury ": 63.36811877106136, "Muscle haemorrhage ": 231.06293822332853, "Peripheral swelling ": 2.661680718730477, "Product dose omission issue ": 2.3884121023472304, "Traumatic haemorrhage ": 891.2060412906651} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/638.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/638.json new file mode 100644 index 00000000000..d5a9ea13055 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/638.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 19.63690358637492, "Aggression ": 4.067437477392114, "Amino acid level increased ": 2041.1466107797487, "Anaphylactic reaction ": 4.3307456980514765, "Anxiety ": 2.212205437105592, "Depression ": 4.440819536219736, "Exposure during pregnancy ": 3.4241582567129507, "Gastrooesophageal reflux disease ": 3.1855983746183605, "Maternal exposure during pregnancy ": 14.039416233340251, "Premature baby ": 8.506722303138876, "Seizure ": 4.2155182319025855, "Therapy non-responder ": 8.788457364335828, "Throat tightness ": 7.929692773991227} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/639.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/639.json new file mode 100644 index 00000000000..f7d977f5446 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/639.json @@ -0,0 +1 @@ +{"Activated partial thromboplastin time prolonged ": 11.55304010966129, "Acute graft versus host disease in skin ": 6.362211731247109, "Acute lymphocytic leukaemia ": 90.54376377264838, "Acute lymphocytic leukaemia recurrent ": 584.0499794171417, "Acute lymphocytic leukaemia refractory ": 132.35339382448248, "Aphasia ": 3.975692058042827, "Apraxia ": 11.735727412449387, "Atelectasis ": 4.00220821779747, "B precursor type acute leukaemia ": 80.35453078541197, "B-cell aplasia ": 3400.4029704541445, "B-cell type acute leukaemia ": 203.59502564334872, "B-lymphocyte count abnormal ": 1929.585872279043, "Bacteraemia ": 4.141837613329832, "Blast cell count increased ": 86.52630852031776, "Blood albumin decreased ": 7.287499776215023, "Blood calcium decreased ": 5.421222115419543, "Blood chloride increased ": 10.89032492788458, "Blood fibrinogen decreased ": 66.71422532841393, "Blood fibrinogen increased ": 50.14012708155608, "Blood lactate dehydrogenase increased ": 6.22835359434703, "Blood phosphorus decreased ": 7.981567287742407, "Blood potassium decreased ": 3.0609553439728923, "Blood pressure systolic decreased ": 5.956464603966593, "Bone lesion ": 14.103931280489345, "Bone marrow disorder ": 11.097710664018605, "Bone marrow failure ": 6.96689146524679, "Brain oedema ": 3.950546775118291, "C-reactive protein decreased ": 31.558231966858525, "C-reactive protein increased ": 6.127000129911542, "Capillary leak syndrome ": 25.71118295925762, "Carbon dioxide decreased ": 21.223514497999616, "Central nervous system leukaemia ": 89.18146417743372, "Central nervous system lymphoma ": 26.42000969427001, "Clostridium difficile colitis ": 5.132989245704502, "Coagulopathy ": 18.811886412506823, "Congenital aplasia ": 10.052785113625568, "Cytokine release syndrome ": 586.2176351714313, "Cytokine storm ": 35.87193091251117, "Cytomegalovirus infection ": 3.52619971716912, "Cytopenia ": 29.985330289574986, "Diffuse large B-cell lymphoma ": 281.69919468589995, "Diffuse large B-cell lymphoma recurrent ": 376.9993592030765, "Diffuse large B-cell lymphoma refractory ": 125.3572413811146, "Disease progression ": 2.1319660540186987, "Disease 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"Incontinence ": 2.358406836584282, "Inflammatory marker increased ": 7.161187893129215, "Interleukin level increased ": 125.56499856297658, "Intracranial pressure increased ": 3.5156190512935344, "Left ventricular dysfunction ": 6.337394284218184, "Leukaemia recurrent ": 10.81243580264405, "Localised oedema ": 2.921036106234984, "Loss of CAR T-cell persistence ": 1719.9631390808895, "Lymphocyte count decreased ": 22.333219464869316, "Lymphoma ": 7.175316025947196, "Lymphopenia ": 2.6902697229658705, "Malignant neoplasm progression ": 16.231291541400513, "Mean cell haemoglobin concentration increased ": 63.47993213053206, "Mental status changes ": 5.526766816122155, "Metastases to central nervous system ": 2.8065009163255565, "Metastases to meninges ": 17.4087257488375, "Minimal residual disease ": 403.7936048847712, "Multiple organ dysfunction syndrome ": 5.148071230720524, "Myelodysplastic syndrome ": 5.44973197528824, "Nervous system disorder ": 6.08858583728322, "Neurological decompensation ": 19.10260970130401, "Neurotoxicity ": 66.64143421379781, "Neutropenia ": 2.934549689507614, "Neutrophil count decreased ": 4.987939989390185, "Non-Hodgkin's lymphoma ": 8.82161451713208, "Oliguria ": 4.218055009751324, "Optic neuritis ": 2.4056935949643994, "Out of specification test results ": 994.662270761931, "Oxygen saturation decreased ": 3.0504200676910527, "Pancytopenia ": 6.835060632109216, "Platelet count decreased ": 4.198761806161137, "Pleural effusion ": 2.065617109154086, "Pneumonia fungal ": 7.032640355274652, "Post-depletion B-cell recovery ": 14899.032451876572, "Protein total decreased ": 9.225437549353147, "Prothrombin time prolonged ": 7.042070123370153, "Pyrexia ": 2.615402906920072, "Red blood cell count decreased ": 5.592592327324308, "Red cell distribution width increased ": 9.114433446266275, "Remission not achieved ": 95.7618000705373, "Respiratory rate increased ": 3.822219750053017, "Second primary malignancy ": 20.21401009052694, "Septic shock ": 3.3417569749010974, "Serum ferritin increased ": 65.39416401357049, "T-cell lymphoma ": 33.08506731837743, "Tachycardia ": 2.503902500181681, "Tachypnoea ": 7.78723374135085, "Therapeutic product effect incomplete ": 4.7445036753695, "Therapy non-responder ": 5.525898789947751, "Therapy partial responder ": 4.801821557044752, "Thrombocytopenia ": 2.279121147127703, "Transformation to acute myeloid leukaemia ": 77.33313869724412, "Tumour lysis syndrome ": 10.239030383835916, "White blood cell count decreased ": 2.96821724130266, "White blood cell count increased ": 2.6052933391243687} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/64.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/64.json new file mode 100644 index 00000000000..0ef87707ebe --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/64.json @@ -0,0 +1 @@ +{"Balance disorder ": 40.79774938731653, "Blood calcium decreased ": 312.51976967612313, "Cognitive disorder ": 76.04273014064854, "Constipation ": 20.514520952899133, "Creatinine renal clearance decreased ": 394.00520379334097, "Depressed level of consciousness ": 53.033409088262985, "Fall ": 14.23524208288276, "Hypotension ": 12.83796113095845, "Mobility decreased ": 50.21150595409613, "Orthostatic hypotension ": 119.60831844115344, "Pain ": 4.720173517702025, "Sedation ": 133.3674006465891, "Sedation complication ": 426.37345282822974, "Toxicity to various agents ": 18.03602615306352} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/640.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/640.json new file mode 100644 index 00000000000..7b7c9d8817e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/640.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 8.319614759999924, "Acute kidney injury ": 4.064708399032767, "Acute myocardial infarction ": 3.221901239672089, "Acute pulmonary oedema ": 18.695398726695792, "Acute respiratory distress syndrome ": 8.637716010481396, "Acute respiratory failure ": 3.782422941823484, "Anaemia ": 2.7110627871705035, "Angina pectoris ": 2.0262142518999027, "Atrial fibrillation ": 4.909313221028522, "Atypical haemolytic uraemic syndrome ": 172.1886774658512, "Blood creatinine increased ": 2.000381789456292, "Blood pressure abnormal ": 2.6691477146763685, "Brain natriuretic peptide increased ": 23.84739247449997, "Cardiac disorder ": 4.42402150238164, "Cardiac dysfunction ": 17.464612573566626, "Cardiac failure ": 28.885854139518468, "Cardiac failure acute ": 30.085286773686374, "Cardiac failure chronic ": 8.164183437982837, "Cardiac failure congestive ": 6.127066970679661, "Cardiomyopathy ": 7.437395059637401, "Cardiotoxicity ": 39.31032247622005, "Cardiovascular disorder ": 2.125939971835359, "Cytomegalovirus infection ": 2.827877298428241, "Cytopenia ": 14.919717924560818, "Deep vein thrombosis ": 2.505526223715434, "Diastolic dysfunction ": 16.898640232751088, "Disease progression ": 3.762459405313519, "Ejection fraction decreased ": 16.78775303233424, "Electrocardiogram QT prolonged ": 2.5183917968040723, "Extravasation ": 23.3146038766316, "Febrile neutropenia ": 4.2226366309294905, "Haemolysis ": 6.098184267762944, "Haemolytic anaemia ": 9.987702033127498, "Haemolytic uraemic syndrome ": 31.87407445538449, "Hepatotoxicity ": 3.050491475426421, "Hypercalcaemia ": 4.883966232416806, "Hypertension ": 4.5968470327037, "Hypertensive crisis ": 7.544241445533405, "Hypervolaemia ": 5.086940471619675, "Infection ": 3.6894298200637, "Infusion site erythema ": 21.52517691668857, "Infusion site extravasation ": 133.22205638618416, "Infusion site pain ": 35.94145743829901, "Interstitial lung disease ": 2.255682987423362, "Left ventricular dysfunction ": 6.130115922622025, "Lymphocyte count decreased ": 4.577901740844326, "Microangiopathic haemolytic anaemia ": 70.73904893702823, "Myelosuppression ": 3.31188692151381, "Myocardial infarction ": 2.52365714068476, "Myocardial ischaemia ": 4.063369566035392, "Neuropathy peripheral ": 5.85183137619829, "Neutropenia ": 3.80222886730716, "Neutrophil count decreased ": 6.307002339479891, "Off label use ": 2.3235294685698795, "Pancytopenia ": 4.412198175842415, "Pericardial effusion ": 2.608800387345995, "Plasma cell myeloma ": 62.7449831745164, "Plasma cell myeloma recurrent ": 81.70648494324013, "Plasmacytoma ": 100.71757198604698, "Platelet count decreased ": 7.793683052878061, "Pleural effusion ": 2.3427551917676555, "Pneumonia ": 5.159392132966562, "Pneumonitis ": 4.666072869667799, "Posterior reversible encephalopathy syndrome ": 13.729202611871049, "Pulmonary arterial hypertension ": 8.058510628485982, "Pulmonary congestion ": 4.6360577124864655, "Pulmonary hypertension ": 26.788262446063747, "Pulmonary oedema ": 7.658450059119675, "Renal disorder ": 3.0720149174555167, "Renal failure ": 2.8325731897393047, "Renal impairment ": 4.343590076557106, "Respiratory tract infection ": 6.063136943316445, "Sepsis ": 4.617934973253056, "Septic shock ": 4.046336850114739, "Sudden death ": 2.90004545709605, "Therapy non-responder ": 2.2703102378504654, "Therapy partial responder ": 14.653631436557214, "Thrombocytopenia ": 7.325139805720767, "Thrombotic microangiopathy ": 98.46651724580556, "Thrombotic thrombocytopenic purpura ": 29.521433685834456, "Tumour lysis syndrome ": 72.67557157412313, "Unevaluable event ": 2.8518232924438056, "Upper respiratory tract infection ": 2.0821663667857635, "White blood cell count decreased ": 2.320966858333112} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/641.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/641.json new file mode 100644 index 00000000000..6ac1ede8fd8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/641.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 2.1361917251404274, "Accidental death ": 29.165359052692548, "Acidosis ": 3.792393558189127, "Acidosis hyperchloraemic ": 86.28816720019404, "Acute hepatic failure ": 4.500674491304552, "Aggression ": 5.456948478188613, "Agitation ": 2.73725489154508, "Anticonvulsant drug level above therapeutic ": 59.6952048166675, "Anticonvulsant drug level below therapeutic ": 29.92555352076628, "Anticonvulsant drug level increased ": 20.78181766814305, "Apathy ": 2.3270785485008907, "Aphasia ": 2.749392822087687, "Ataxia ": 8.123048307583291, "Atrioventricular block ": 5.693912997976467, "Atrioventricular block complete ": 12.777282161773538, "Atrioventricular block first degree ": 10.593833958024645, "Atrioventricular block second degree ": 16.249035453385087, "Aura ": 14.354161164108277, "Balance disorder ": 2.273378271303595, "Behaviour disorder ": 8.239082236076753, "Blood chloride increased ": 59.27522587770058, "Blood pH decreased ": 52.59603691086101, "Bradycardia ": 2.6396312013192538, "Cardiac arrest ": 2.941854227651338, "Cardio-respiratory arrest ": 3.013959851288462, "Cardiotoxicity ": 16.55230723782678, "Coarctation of the aorta ": 26.323474854741374, "Cognitive disorder ": 6.854390077970682, "Condition aggravated ": 3.0838644583301016, "Delusion ": 2.9395603900521805, "Depressed mood ": 2.986347093768269, "Dermatitis allergic ": 3.1859877651811277, "Developmental delay ": 4.735219401114477, "Diplopia ": 13.4681378783447, "Disease recurrence ": 4.323052699964014, "Drug effective for unapproved indication ": 9.19346987839598, "Drug ineffective ": 8.52711286977518, "Drug ineffective for unapproved indication ": 12.78595529019636, "Drug interaction ": 4.197265335711255, "Drug level decreased ": 8.494667313459026, "Drug reaction with eosinophilia and systemic symptoms ": 2.915482333301618, "Drug resistance ": 23.80958056751449, "Drug withdrawal convulsions ": 17.106628121265516, "Dysarthria ": 2.302824382642821, "Dyskinesia ": 2.1052859502188457, "Electrocardiogram QRS complex prolonged ": 20.45671238813517, "Encephalitis ": 2.815508154519119, "Encephalopathy ": 5.041979811322614, "Epilepsia partialis continua ": 198.26593683567603, "Epilepsy ": 17.709001398372894, "Exposure during pregnancy ": 3.5938983485307743, "Eye movement disorder ": 4.374897332151165, "Focal dyscognitive seizures ": 107.43070588901185, "Foetal exposure during pregnancy ": 3.9444909902749337, "Generalised tonic-clonic seizure ": 19.27628586420693, "Hyperbilirubinaemia ": 2.737058832351046, "Hypokalaemia ": 2.6388937202681504, "Hypoventilation ": 6.940039891958013, "Ileus ": 2.825157680906482, "Incorrect route of product administration ": 3.531745660410877, "Intensive care unit acquired weakness ": 117.70002922557444, "Intentional self-injury ": 2.473835428227112, "Irritability ": 2.7945336759756816, "Ischaemia ": 6.019949753652213, "Low birth weight baby ": 4.229220586169486, "Macroglossia ": 51.73103555922069, "Magnetic resonance imaging head abnormal ": 26.60207033401084, "Malnutrition ": 4.413136517393929, "Maternal exposure before pregnancy ": 8.317683615015683, "Maternal exposure during pregnancy ": 5.589082799254214, "Medication error ": 4.813553254079814, "Mental status changes ": 2.0492778987998506, "Metabolic acidosis ": 3.252722006761424, "Multiple organ dysfunction syndrome ": 2.147959179417983, "Multiple-drug resistance ": 290.1051023038506, "Muscle twitching ": 2.033885156191307, "Myoclonic epilepsy ": 35.509268693550474, "Myoclonus ": 6.623771508870318, "Neonatal seizure ": 96.87803389142852, "Neurotoxicity ": 14.167596075578876, "No adverse event ": 2.171717353624054, "Nodal rhythm ": 16.04346081937672, "Nystagmus ": 16.354456111143946, "Off label use ": 4.658081383789972, "Overdose ": 2.695134369652358, "Parkinsonism ": 2.7560485677460216, "Partial seizures ": 94.6800849143202, "Partial seizures with secondary generalisation ": 70.69648296726015, "Petit mal epilepsy ": 23.317908781810512, "Pneumonia aspiration ": 4.601091124815817, "Premature baby ": 3.538757496942015, "Premature delivery ": 10.297646952277118, "Product substitution issue ": 4.598251383730196, "Product use in unapproved indication ": 2.0259839391451173, "Product use issue ": 2.8886168233752945, "Psychotic disorder ": 3.3460934829432505, "Respiratory acidosis ": 7.003539522978501, "Respiratory rate increased ": 6.409744742454692, "Schizophrenia ": 3.3964395526113127, "Sedation ": 5.622788111011199, "Seizure ": 19.554717323718425, "Seizure cluster ": 71.11065700603598, "Sinus bradycardia ": 4.872571057607204, "Sinus tachycardia ": 3.424921018239825, "Skin warm ": 4.352616815764342, "Somnolence ": 2.954087173204213, "Staring ": 9.848477393531736, "Status epilepticus ": 122.35488654171624, "Stevens-Johnson syndrome ": 3.641457700222728, "Stupor ": 4.743530213663774, "Sudden unexplained death in epilepsy ": 60.46357006754184, "Therapeutic product effect incomplete ": 6.7957209408945, "Therapeutic response decreased ": 4.123239760761429, "Therapy non-responder ": 3.9451058821642935, "Tonic convulsion ": 27.920142904707436, "Toxic epidermal necrolysis ": 3.7998664101949, "Toxicity to various agents ": 3.667838127629629, "Treatment failure ": 7.615125630124234, "Treatment noncompliance ": 3.1059086895020696, "Unmasking of previously unidentified disease ": 91.91817135707836, "Unresponsive to stimuli ": 2.656981468627845, "Ventricular tachycardia ": 4.637612025704618, "White matter lesion ": 91.1754273084334, "Wrong patient received product ": 17.463635005115616} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/642.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/642.json new file mode 100644 index 00000000000..fb10af4c377 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/642.json @@ -0,0 +1 @@ +{"Cough ": 5.139991357606849, "Deafness ": 48.54162470990339, "Dysphonia ": 19.474822639182825, "Dyspnoea ": 2.058255230976417, "Haemoptysis ": 29.319983795503493, "Hospitalisation ": 13.920478688864495, "Infective pulmonary exacerbation of cystic fibrosis ": 159.55301259006828, "Off label use ": 5.56102101753493, "Pneumonia ": 4.2233570874079405, "Product dose omission issue ": 8.72727438088926} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/643.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/643.json new file mode 100644 index 00000000000..c6c0a1a6891 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/643.json @@ -0,0 +1 @@ +{"Abortion induced ": 7.052488303638123, "Abortion spontaneous ": 2.324682801906542, "Acidosis ": 4.607419543616195, "Acquired gene mutation ": 33.238896139176376, "Acute hepatic failure ": 11.273679665831851, "Acute respiratory failure ": 3.186311737475385, "Alanine aminotransferase increased ": 2.064056259812392, "Anaemia ": 2.307640542166929, "Anion gap increased ": 32.785953755349425, "Aphthous ulcer ": 3.518316360843172, "Ascites ": 3.254510077463169, "Atrioventricular block complete ": 4.485437309553661, "Blood HIV RNA increased ": 44.768193447434825, "Blood alkaline phosphatase increased ": 2.0771486282320777, "Blood bilirubin increased ": 2.4118946503528287, "Blood lactic acid increased ": 18.976647894607986, "Blood triglycerides increased ": 2.870412780134394, "Bronchial hyperreactivity ": 32.69532221930547, "CD4 lymphocytes decreased ": 43.354955896552994, "CD4 lymphocytes increased ": 261.3801588479279, "CSF HIV escape syndrome ": 130.4136955617939, "Cachexia ": 7.106099736861508, "Cardiac murmur ": 5.138688176925462, "Cardiomyopathy ": 3.812885749307082, "Central nervous system lesion ": 9.040011859027077, "Cervical dysplasia ": 17.016252262998087, "Clavicle fracture ": 12.020634184707609, "Coagulopathy ": 2.989894582463382, "Conjunctivitis ": 2.0377013114823663, "Cryptococcosis ": 67.57234709249312, "Cytomegalovirus infection ": 4.344323192341329, "Dermatitis exfoliative ": 8.587223678650858, "Developmental delay ": 10.001351611838178, "Dilated cardiomyopathy ": 9.535679925356042, "Disseminated intravascular coagulation ": 2.933873924414, "Disseminated tuberculosis ": 22.91546804222777, "Drug resistance ": 10.233656324555149, "Drug-induced liver injury ": 2.6132957782497845, "Encephalitis ": 3.4205823407608933, "Encephalopathy ": 2.128890292933612, "Exposure during pregnancy ": 3.5717122455914927, "Failure to thrive ": 11.808773758426742, "Foetal death ": 4.398106692919867, "Foetal exposure during pregnancy ": 9.90235945375504, "Gamma-glutamyltransferase increased ": 2.071123211880536, "Granuloma ": 10.70561463647167, "HIV infection ": 84.26817768120603, "HIV-associated neurocognitive disorder ": 120.47572943055047, "Hepatic cirrhosis ": 2.423112709854484, "Hepatic encephalopathy ": 11.26171137728526, "Hepatic failure ": 8.14290679146103, "Hepatic function abnormal ": 2.688355880050378, "Hepatic steatosis ": 4.955490336452736, "Hepatitis ": 3.5392965537070853, "Hepatitis B ": 23.88655440692921, "Hepatitis B reactivation ": 30.03203632840066, "Hepatomegaly ": 24.622710880008647, "Hepatosplenomegaly ": 35.059602296950295, "Hepatotoxicity ": 7.983379440648861, "Hyperbilirubinaemia ": 3.627244885292161, "Hypercholesterolaemia ": 10.348829177875848, "Hyperlactacidaemia ": 26.679554344313985, "Hypertriglyceridaemia ": 16.378838925631023, "Hypoalbuminaemia ": 11.400843057685156, "Immune reconstitution inflammatory syndrome ": 240.4610028291607, "Injection site ulcer ": 37.96669611181628, "Intracranial pressure increased ": 8.50540643702899, "Jaundice ": 7.19710398418993, "Joint dislocation ": 7.401791026363712, "Kaposi's sarcoma ": 22.47138384422397, "Lactic acidosis ": 11.65414318888806, "Leprosy ": 201.357822559237, "Lipoatrophy ": 43.77061911694503, "Lipodystrophy acquired ": 23.014576515920773, "Live birth ": 6.563415513755155, "Liver function test abnormal ": 3.989939901651817, "Liver injury ": 5.951574222691468, "Low birth weight baby ": 6.447978394621438, "Low set ears ": 70.34112268644077, "Lung infiltration ": 6.108716639535079, "Lymphadenitis ": 23.85832530233409, "Macrocytosis ": 30.990901072345288, "Maternal exposure during pregnancy ": 2.054066480569113, "Meningitis cryptococcal ": 108.48959861935464, "Metabolic acidosis ": 5.42732983525791, "Mitochondrial toxicity ": 45.18824138855129, "Molluscum contagiosum ": 209.13265569696145, "Mouth ulceration ": 2.092034122131244, "Multiple-drug resistance ": 6.862826082977011, "Muscle spasticity ": 4.27607627736016, "Mycobacterial infection ": 38.404652003389984, "Mycobacterium avium complex infection ": 19.15581025306196, "Nephropathy toxic ": 4.099949308267737, "Nephrotic syndrome ": 5.450446214539015, "Neuropathy peripheral ": 4.929103031158866, "Nodular regenerative hyperplasia ": 98.9965773969692, "Oedema ": 2.3110925618244105, "Oral candidiasis ": 2.0457059839534777, "Pallor ": 2.7113708571224624, "Pancreatitis ": 2.1340268536953126, "Pancytopenia ": 2.6711823353871, "Papule ": 4.64319458223776, "Pathogen resistance ": 26.15368890218628, "Peripheral ischaemia ": 9.199746292940432, "Pneumocystis jirovecii pneumonia ": 4.145989802783515, "Polyneuropathy ": 2.8258993565133608, "Portal hypertension ": 19.0316419296194, "Pregnancy ": 8.208890626529648, "Premature baby ": 5.498225871974321, "Premature delivery ": 3.7358090888459534, "Progressive multifocal leukoencephalopathy ": 14.334710120202152, "Proteinuria ": 4.448180624175497, "Pulmonary tuberculosis ": 11.216014152130064, "Rash maculo-papular ": 2.3873286857142832, "Respiratory distress ": 2.346521605900777, "Skin lesion ": 9.466962784844132, "Skin mass ": 6.266463227898819, "Skin ulcer ": 2.3569622858840864, "Small for dates baby ": 14.663332322560398, "Splenomegaly ": 7.7809052219685775, "Stevens-Johnson syndrome ": 6.610783681243444, "Stillbirth ": 19.76986616190751, "Tachypnoea ": 3.907032519026677, "Thrombotic microangiopathy ": 4.217252247993341, "Toxic epidermal necrolysis ": 5.688526498137124, "Treatment failure ": 6.494508487398591, "Treatment noncompliance ": 4.319787513504023, "Trisomy 21 ": 52.8840389702044, "Tuberculoid leprosy ": 495.5222310372432, "Tuberculosis ": 18.855335508012224, "Viral load increased ": 8.295727128053338, "Viral mutation identified ": 118.0984434626281, "Virologic failure ": 70.34159354173681, "Visual acuity reduced ": 2.25264336248127} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/644.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/644.json new file mode 100644 index 00000000000..656498151f0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/644.json @@ -0,0 +1 @@ +{"Abdominal hernia ": 2.355554112374048, "Abdominal infection ": 2.8007261832566064, "Abdominal operation ": 4.285708092401096, "Accident ": 2.685401816807518, "Accidental overdose ": 2.804114591425124, "Adverse reaction ": 5.15604615970874, "Age-related macular degeneration ": 3.054851123700373, "Amputation ": 9.558251057920785, "Amyloidosis ": 4.119105636990184, "Angiopathy ": 3.0127469238575046, "Angioplasty ": 3.13454567254831, "Ankle fracture ": 3.0201547846403467, "Anti-insulin antibody increased ": 11.4827297063163, "Anti-insulin antibody positive ": 35.35467224977318, "Aortic valve replacement ": 3.091085838662212, "Application site haemorrhage ": 2.942740076789228, "Arterial occlusive disease ": 3.070562735956315, "Back disorder ": 5.180304724963078, "Bedridden ": 2.98109301987898, "Blindness ": 9.949022010269813, "Blindness unilateral ": 9.289603944321792, "Blood glucose abnormal ": 21.267595568300774, "Blood glucose decreased ": 32.53224215992403, "Blood glucose fluctuation ": 33.10225696034378, "Blood glucose increased ": 26.23893052299988, "Blood insulin increased ": 5.649699182692904, "Blood ketone body ": 15.973630925859489, "Blood ketone body increased ": 5.025602694154197, "Blood potassium abnormal ": 2.0420735759786908, "Brain neoplasm ": 2.466813891399945, "Brain neoplasm malignant ": 2.474876572236433, "Cardiac disorder ": 4.062059302160344, "Cardiac failure congestive ": 2.4310257887861546, "Cardiac operation ": 13.57608205122151, "Cardiac pacemaker insertion ": 4.2814370869064735, "Carotid artery occlusion ": 2.081038859188506, "Carpal tunnel decompression ": 7.631887366467426, "Carpal tunnel syndrome ": 2.30440753332616, "Cartilage injury ": 3.403557763170366, "Cataract ": 17.612958042832147, "Cataract operation ": 29.513441420001868, "Catheter placement ": 2.0127790951034816, "Catheterisation cardiac ": 2.1533918040150595, "Cerebrovascular accident ": 5.316474719448628, "Cervical vertebral fracture ": 2.040806486824206, "Cold sweat ": 3.240300305767987, "Colon cancer ": 2.6898505623140774, "Colour blindness ": 2.510433966817682, "Concussion ": 3.592998592731743, "Corneal disorder ": 2.036670665358729, "Corneal transplant ": 10.779822262876351, "Coronary arterial stent insertion ": 2.897441379422162, "Coronary artery bypass ": 7.961946429772506, "Coronary artery occlusion ": 3.2478223314001315, "Corrective lens user ": 12.103450646998336, "Craniocerebral injury ": 2.578989249239867, "Cutaneous amyloidosis ": 43.80262519404179, "Dawn phenomenon ": 18.7737151219152, "Decubitus ulcer ": 2.2906985771402444, "Dementia ": 6.567545976733981, "Dementia Alzheimer's type ": 9.257957408696306, "Device breakage ": 8.740144279447813, "Device defective ": 9.42054227077613, "Device delivery system issue ": 7.268598659301825, "Device ineffective ": 4.120087918166374, "Device issue ": 22.43846052702027, "Device leakage ": 3.887095327567366, "Device malfunction ": 31.86453614509075, "Device mechanical issue ": 10.136790950380176, "Device operational issue ": 181.95344867559004, "Device use issue ": 10.727584409550742, "Diabetes mellitus inadequate control ": 34.88167805070266, "Diabetic coma ": 19.47879019768367, "Diabetic complication ": 15.237083892737688, "Diabetic eye disease ": 11.68373358423876, "Diabetic foot ": 14.29528794394822, "Diabetic foot infection ": 5.339476095327995, "Diabetic hyperglycaemic coma ": 38.245322027732605, "Diabetic ketoacidosis ": 7.140469382423087, "Diabetic ketosis ": 2.68361910625482, "Diabetic metabolic decompensation ": 14.86399800377885, "Diabetic nephropathy ": 8.231359648154577, "Diabetic neuropathy ": 12.52516731441894, "Diabetic retinal oedema ": 7.864417791616733, "Diabetic retinopathy ": 36.316652952061794, "Dialysis ": 9.391337975736286, "Diet noncompliance ": 18.552145469382896, "Disability ": 14.96175035963657, "Disease complication ": 3.3337199542159484, "Drug dose omission by device ": 3.3367689032953423, "Dysgraphia ": 2.4000154317689018, "Exercise lack of ": 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": 3.966837792041651, "Gallbladder operation ": 5.667574326000998, "Gangrene ": 5.498591432136584, "Gastrointestinal carcinoma ": 2.4089734502361937, "Glaucoma ": 7.999765461225416, "Glycosylated haemoglobin abnormal ": 19.278732903068644, "Glycosylated haemoglobin decreased ": 9.0988217705689, "Glycosylated haemoglobin increased ": 22.41465178153746, "Granuloma annulare ": 3.1316632171121155, "Haemodialysis ": 2.729196550000333, "Heart transplant ": 5.983111762565416, "Heart valve replacement ": 8.501457862876975, "Hepatic neoplasm ": 4.419910209243774, "Hernia repair ": 4.789465869472366, "Hip fracture ": 2.5774553987268227, "Hip surgery ": 2.464907337760337, "Hospitalisation ": 6.643300619071954, "Hunger ": 7.104387778185728, "Hyperbilirubinaemia neonatal ": 5.983111762565416, "Hyperglycaemia ": 37.92088185974232, "Hyperglycaemic unconsciousness ": 33.81586402493104, "Hyperhidrosis ": 2.5936102028849457, "Hyperinsulinaemia ": 5.084539383752847, "Hyperinsulinaemic hypoglycaemia ": 35.51893406154218, "Hypoacusis ": 3.9067271038355855, "Hypoglycaemia ": 35.50558244318425, "Hypoglycaemia neonatal ": 10.928689300473009, "Hypoglycaemia unawareness ": 23.61696632267947, "Hypoglycaemic coma ": 32.332054419103045, "Hypoglycaemic encephalopathy ": 12.699629962793276, "Hypoglycaemic seizure ": 76.27238200974567, "Hypoglycaemic unconsciousness ": 70.97806406373125, "Impaired gastric emptying ": 2.2463411472728363, "Inappropriate schedule of product administration ": 4.0772653104309216, "Incoherent ": 3.982307829384337, "Incorrect dosage administered ": 2.18674080243988, "Incorrect dose administered ": 2.9443627198476, "Incorrect dose administered by device ": 15.015704812605469, "Infarction ": 4.6052191510502185, "Infected skin ulcer ": 3.272265569619563, "Injection site atrophy ": 7.505751393557008, "Injection site bruising ": 8.494217211338384, "Injection site discolouration ": 10.297137879674729, "Injection site extravasation ": 6.496400305891565, "Injection site haemorrhage ": 13.88436056819454, "Injection site infection ": 3.261148882479572, "Injection site injury ": 11.465726945683135, "Injection site irritation ": 2.877473754646858, "Injection site mass ": 4.138643944136933, "Injection site nodule ": 6.113263817932968, "Injection site scar ": 7.296481033139446, "Injection site ulcer ": 2.685024518371889, "Injury associated with device ": 11.233303795427672, "Insulin autoimmune syndrome ": 4.587491908736293, "Insulin resistance ": 7.143135981648835, "Intentional dose omission ": 3.724648034225882, "Intercepted medication error ": 8.892152665791771, "Intervertebral disc disorder ": 2.325655146174492, "Intervertebral disc protrusion ": 3.4612659910634456, "Jaundice neonatal ": 2.950098941339058, "Joint injury ": 2.403380703548882, "Ketoacidosis ": 9.20026625241413, "Ketonuria ": 7.680987524592225, "Ketosis ": 10.197001980418134, "Kidney infection ": 2.634550357109484, "Knee arthroplasty ": 3.192065933464588, "Knee operation ": 5.001206293947275, "Lack of injection site rotation ": 31.081846666495817, "Laryngeal cancer ": 3.93473872246961, "Laziness ": 8.266323136106058, "Leg amputation ": 25.484349441692498, "Leukaemia ": 2.1767884414228598, "Limb injury ": 3.802973060122879, "Limb operation ": 5.096640728170159, "Lipoatrophy ": 2.372196513705373, "Lipodystrophy acquired ": 6.803861244929651, "Lipohypertrophy ": 6.934632441827537, "Liver transplant ": 2.5500822025690746, "Localised infection ": 5.6097284855433935, "Loose tooth ": 2.297169921965453, "Loss of consciousness ": 2.91776864610035, "Lower limb fracture ": 3.170695482729567, "Macular degeneration ": 7.950099283915953, "Macular hole ": 2.001171565263475, "Macular oedema ": 2.0776330519322554, "Medication error ": 4.563657120977821, "Memory impairment ": 2.296339684344088, "Moaning ": 2.468814694805832, "Morning sickness ": 4.977455456457704, "Multimorbidity ": 4.357369219031158, "Multiple drug therapy ": 2.111162610249816, "Multiple use of single-use product ": 35.313953739851186, "Myocardial infarction ": 2.813974321390978, "Neck injury ": 2.133220001331121, "Neck surgery ": 6.545261318096628, "Needle issue ": 2.0471796439686023, "Neoplasm ": 2.5714638328467165, "Neoplasm malignant ": 3.128611695573933, "Nervousness ": 3.1893565617729305, "Neuropathic arthropathy ": 7.403955855428577, "Ocular vascular disorder ": 3.7212808106720168, "Oesophageal carcinoma recurrent ": 90.24235533198424, "Osteomyelitis ": 3.1301743731143272, "Pancreatectomy ": 4.743943228297531, "Pancreatic carcinoma ": 2.2067507224613934, "Pancreatic disorder ": 8.725620980853542, "Pancreatic failure ": 2.8195342904801777, "Pancreatic neoplasm ": 2.942740076789228, "Parkinson's disease ": 3.070154399833378, "Pituitary tumour ": 2.7059341991172, "Pollakiuria ": 2.0080214006230075, "Poor peripheral circulation ": 3.076559145535576, "Postoperative wound infection ": 2.0365822140546115, "Pre-eclampsia ": 2.118468687474817, "Product administration error ": 12.107783947080874, "Product complaint ": 15.815190102846028, "Product counterfeit ": 4.233259282086727, "Product dose omission issue ": 3.4634842425507824, "Product odour abnormal ": 3.2670598897362484, "Product prescribing issue ": 2.644677382771607, "Product quality issue ": 3.993240893555362, "Product storage error ": 32.01127937242492, "Product use issue ": 4.266443632576364, "Prostatic operation ": 6.062088515207667, "Rectal tenesmus ": 3.1312781005560457, "Renal disorder ": 5.358813356077079, "Renal mass ": 2.236645973930348, "Renal neoplasm ": 2.047031086281009, "Renal transplant ": 19.756837442483185, "Retinal detachment ": 6.718202425451579, "Retinal disorder ": 12.232723493107692, "Retinal haemorrhage ": 6.276948999911585, "Retinal injury ": 6.299003078128232, "Retinopathy ": 18.3638935691191, "Retinopathy proliferative ": 20.994863863076667, "Road traffic accident ": 4.270329993671052, "Rotator cuff repair ": 6.822033855851455, "Rotator cuff syndrome ": 2.372459925156543, "Sciatic nerve injury ": 4.982175767001625, "Shock hypoglycaemic ": 20.4753558819406, "Shoulder arthroplasty ": 2.6598471128970176, "Shoulder fracture ": 3.490140314836656, "Shoulder operation ": 4.958150420739237, "Silent myocardial infarction ": 6.3251579321365, "Skin ulcer ": 2.467221645283989, "Sluggishness ": 3.863098570380712, "Sopor ": 3.517566436496857, "Speech disorder ": 2.1145559751661924, "Spinal cord injury ": 2.1571694582739065, "Spinal disorder ": 3.4331766071536385, "Spinal operation ": 6.268458929239602, "Staphylococcal infection ": 2.2280380165844624, "Stent placement ": 4.091713715909145, "Surgery ": 4.072685878518728, "Suspected counterfeit product ": 2.553070957193883, "Suspected product quality issue ": 3.0273377899949354, "Therapeutic product ineffective ": 2.1525876210694275, "Thirst ": 2.5293677589527666, "Throat cancer ": 2.446919768280144, "Thyroid cancer ": 2.114894516299211, "Toe amputation ": 22.55648727604941, "Trigger finger ": 2.550620985438864, "Unevaluable event ": 5.222064746174999, "Upper limb fracture ": 3.18450455080312, "Urinary tract infection ": 2.062596537718892, "Urine ketone body present ": 7.59532391588997, "Vascular dementia ": 4.798684584508915, "Vascular graft ": 16.099129662206444, "Vascular occlusion ": 5.3724549000572965, "Venous occlusion ": 2.741200331716972, "Vision blurred ": 2.247417440345172, "Visual impairment ": 8.79495953480712, "Vitreous disorder ": 4.320915376117243, "Vitreous haemorrhage ": 11.539845453603514, "Walking aid user ": 7.077519893082665, "Weight increased ": 2.867050896740208, "Wheelchair user ": 12.950056083919891, "Wrist fracture ": 2.320505649155228, "Wrong device used ": 21.310252250294347, "Wrong product administered ": 7.689404909033826, "Wrong technique in device usage process ": 12.03079139240895, "Wrong technique in product usage process ": 3.0799391981728483} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/645.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/645.json new file mode 100644 index 00000000000..c86187d462f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/645.json @@ -0,0 +1 @@ +{"Intraocular pressure increased ": 308.75645539874336} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/646.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/646.json new file mode 100644 index 00000000000..577df95ef94 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/646.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 7.180708771614565, "Abulia ": 14.08647118210864, "Activation syndrome ": 91.89019179892796, "Affective disorder ": 5.976906178180464, "Aggression ": 6.252346600649236, "Agitation ": 4.095702196641973, "Akathisia ": 50.277405798980354, "Anger ": 13.500701450748942, "Anxiety ": 3.307393947750888, "Apathy ": 4.918695597125134, "Autism spectrum disorder ": 4.740991880305043, "Aversion ": 58.86945696779946, "Bipolar I disorder ": 32.33995462696452, "Bipolar disorder ": 57.76609162170238, "Blepharospasm ": 3.237365173149017, "Blood prolactin increased ": 26.334610390357557, "Blood triglycerides increased ": 2.547497133082527, "Blunted affect ": 30.981787930057248, "Bradyphrenia ": 3.042817636044981, "Brain injury ": 3.477766499593059, "Bruxism ": 17.753558010888593, "Catatonia ": 13.731708102417722, "Cognitive disorder ": 2.251336355519759, "Cogwheel rigidity ": 19.781820449664394, "Completed suicide ": 3.998016621997286, "Crying ": 5.783397321441616, "Decreased activity ": 3.881731015195834, "Delusion ": 18.190018083578504, "Depressed mood ": 4.72369524387399, "Depression ": 5.1761089234389415, "Depressive symptom ": 8.108743596904244, "Diabetes mellitus ": 2.2540518432200427, "Drooling ": 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"Hallucination ": 4.676230114320489, "Hallucination, auditory ": 30.601852506935607, "Hallucination, visual ": 3.087308699109023, "Head injury ": 2.049495255294012, "Homicidal ideation ": 14.177840724623346, "Hostility ": 10.946057070999917, "Hyperprolactinaemia ": 51.74356191240668, "Hypersomnia ": 2.4351623363602144, "Hyperventilation ": 3.0548652769830373, "Hypomania ": 8.795684790603806, "Impulsive behaviour ": 12.267298597575476, "Increased appetite ": 7.884965215555664, "Initial insomnia ": 2.301809176501264, "Insomnia ": 3.4342148837405047, "Intentional dose omission ": 4.296082312664163, "Intentional self-injury ": 8.39948755539375, "Irritability ": 3.546732087007208, "Logorrhoea ": 8.188355011155997, "Major depression ": 10.670326275528408, "Malabsorption ": 2.478510551521283, "Mania ": 36.81915325790826, "Mental disorder ": 6.165308565013028, "Mental impairment ": 5.767121979839229, "Metabolic surgery ": 20.2521963370098, "Middle insomnia ": 2.0868334972548768, "Mood altered ": 4.688870847023732, "Mood swings ": 6.207860266090219, "Muscle rigidity ": 6.943846111455374, "Musculoskeletal stiffness ": 2.049140616977808, "Near death experience ": 4.683636252556969, "Negative thoughts ": 12.210437613776168, "Nervousness ": 2.082205177468173, "Neuroleptic malignant syndrome ": 11.85959994627396, "Nightmare ": 2.063048762003044, "Obesity ": 4.261541041772467, "Obsessive thoughts ": 19.337806689170385, "Obsessive-compulsive disorder ": 4.327155416712492, "Oculogyric crisis ": 89.56453064257155, "Off label use ": 5.092843707370842, "Oromandibular dystonia ": 41.06326569656673, "Panic attack ": 6.119671745237946, "Panic reaction ": 3.1106919729643723, "Paranoia ": 13.471220864343618, "Parkinson's disease ": 3.670973563437508, "Parkinsonism ": 10.460422764586962, "Persecutory delusion ": 11.349998166176958, "Personality change ": 2.784330587886993, "Physical assault ": 13.267118074208542, "Physical deconditioning ": 3.953999088860821, "Pneumonia aspiration ": 2.0572458510186435, "Polydipsia ": 9.138487424797011, "Poor quality sleep ": 2.4843087966396897, "Post-traumatic stress disorder ": 15.111620668454814, "Pregnancy ": 11.366393886709735, "Prescribed overdose ": 4.176899015217927, "Prescribed underdose ": 26.845203589340443, "Product administered to patient of inappropriate age ": 5.531422011277158, "Product administration error ": 6.974510321680538, "Product dose omission issue ": 2.319771403414354, "Product use in unapproved indication ": 2.119225659326246, "Psychiatric decompensation ": 8.074227299509102, "Psychiatric symptom ": 15.73146219237784, "Psychomotor hyperactivity ": 5.52750750606705, "Psychotic disorder ": 10.779290717492495, "Psychotic symptom ": 37.1786391081467, "Restless legs syndrome ": 5.713083208448298, "Restlessness ": 8.107758523362023, "Road traffic accident ": 2.295264592706149, "Salivary hypersecretion ": 6.851420571599473, "Schizoaffective disorder ": 19.77172888196404, "Schizophrenia ": 37.88318525932536, "Screaming ": 6.0883371726773685, "Sedation ": 3.95296038508841, "Sedation complication ": 3.336596807987536, "Seizure ": 2.0623166900481475, "Self-destructive behaviour ": 15.265871679827743, "Self-injurious ideation ": 25.60733161160183, "Serotonin syndrome ": 2.6108654168673247, "Sleep apnoea syndrome ": 2.118349250164602, "Social avoidant behaviour ": 6.315277835281716, "Soliloquy ": 22.695998013031364, "Somnambulism ": 5.197930357832098, "Somnolence ": 2.1809391711168744, "Speech disorder ": 2.904407322262264, "Stress ": 2.730203913937683, "Suicidal behaviour ": 12.417734567667315, "Suicidal ideation ": 26.10870667323299, "Suicide attempt ": 6.126282653605212, "Swollen tongue ": 3.63075821030564, "Tachyphrenia ": 31.770158734798905, "Tardive dyskinesia ": 107.3720914635213, "Temperature intolerance ": 2.642258719239546, "Therapeutic response decreased ": 2.0228410513480406, "Therapeutic response unexpected ": 3.0705175838565784, "Therapy cessation ": 33.821684600323465, "Therapy 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27.82921476166062, "Death ": 14.433444390086231} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/648.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/648.json new file mode 100644 index 00000000000..21883ec185e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/648.json @@ -0,0 +1 @@ +{"Drug ineffective ": 2.871209371660338, "Drug interaction ": 19.470729618646136, "Hepatitis C ": 39.02832528485297, "Treatment failure ": 17.78295435024443} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/649.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/649.json new file mode 100644 index 00000000000..1dcf0ff08d0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/649.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.440540793052435, "Acne ": 3.6720547016425527, "Acute lung injury ": 121.48399723409564, "Adverse drug reaction ": 2.203797540593831, "Ankle fracture ": 4.64320478763225, "Arthritis ": 5.498450337347067, "Arthropathy ": 2.899907381522649, "Blood cholesterol increased ": 2.1151043422958065, "Blood pressure abnormal ": 2.2599612764483537, "Blood pressure diastolic abnormal ": 22.28836922140312, "Blood pressure systolic increased ": 4.150563339078497, "Bone erosion ": 10.50742902563494, "C-reactive protein increased ": 7.850170346210012, "Cellulitis ": 2.681727716739034, "Clostridium difficile infection ": 5.549922001958949, "Condition aggravated ": 2.159577601642348, "Crepitations ": 17.464828796730547, "Cytopenia ": 4.381435759784064, "Deformity ": 9.379888225363912, "Device fastener issue ": 1472.9822109090417, "Diverticulitis ": 14.45426103677082, "Drug hypersensitivity ": 3.047417980423731, "Drug ineffective ": 4.235597930815383, "Drug intolerance ": 15.055739002464843, "Drug-induced liver injury ": 5.118796236421479, "Dry eye ": 4.9452024721361205, "Dyspepsia ": 4.0609809584913, "Dysstasia ": 2.7147257995655925, "Exostosis ": 31.059253648534103, "Fibromyalgia ": 2.7841927450300004, "Foot deformity ": 13.97841201200264, "Foot fracture ": 2.918000043729168, "Frustration tolerance decreased ": 16.532099030372613, "Gastrointestinal disorder ": 5.070102868504719, "General physical health deterioration ": 2.8663575442288405, "General symptom ": 35.48625296959275, "Gingival abscess ": 172.28820687917533, "Gingival disorder ": 31.410858184114343, "Grip strength decreased ": 8.337991583931341, "Hand deformity ": 6.888812585821236, "Heart rate decreased ": 2.087218048957104, "Hepatic enzyme increased ": 4.739553704481245, "Hepatitis ": 3.167326315168878, "Ill-defined disorder ": 2.501292671760513, "Immunodeficiency ": 9.104319473849802, "Impaired healing ": 2.775554771305538, "Inflammation ": 3.305211469604857, "Joint dislocation ": 9.49179086184493, "Joint effusion ": 11.517791896533558, "Joint range of motion decreased ": 4.962151690682721, "Joint space narrowing ": 153.82420829794847, "Joint stiffness ": 2.841665804021809, "Joint swelling ": 10.527028446441618, "Juvenile idiopathic arthritis ": 17.825178915798027, "Laryngitis ": 12.485960102208224, "Leukopenia ": 2.056674393925776, "Lower respiratory tract infection ": 2.124087522405213, "Lymphocyte count decreased ": 3.422720480392464, "Mucous stools ": 21.005494902487907, "Musculoskeletal chest pain ": 4.726300449926645, "Musculoskeletal pain ": 2.3547135992354824, "Musculoskeletal stiffness ": 7.059125854719007, "Mycobacterium tuberculosis complex test positive ": 74.57893324652491, "Nasopharyngitis ": 2.397072080088689, "Neuropathy peripheral ": 2.043395218028026, "Nodule ": 4.696685871091507, "Normocytic anaemia ": 13.671963942845345, "Osteoarthritis ": 7.81704667384628, "Osteosclerosis ": 43.03121409068424, "Pancytopenia ": 2.0534196917129237, "Peripheral swelling ": 2.8898103802668995, "Pharyngeal swelling ": 2.4240670151370165, "Pigmentation disorder ": 11.889443453400656, "Pneumonitis ": 2.2903918331519293, "Polyarthritis ": 8.222074524367118, "Polyneuropathy ": 2.538510396295617, "Psoriasis ": 3.532014189991952, "Psoriatic arthropathy ": 13.375046521121352, "Pulmonary fibrosis ": 2.842033001405201, "Pulmonary toxicity ": 5.859949083856921, "Raynaud's phenomenon ": 6.078728777216509, "Red blood cell sedimentation rate increased ": 12.469854878167524, "Rheumatoid arthritis ": 13.263950877693098, "Rheumatoid nodule ": 22.93922105038044, "Seronegative arthritis ": 41.29968506120468, "Sinusitis ": 3.1230218728682204, "Sjogren's syndrome ": 11.65216857707072, "Skin lesion ": 2.3151985521192997, "Skin plaque ": 12.368737747488233, "Skin ulcer ": 2.883054350028196, "Suspected suicide ": 5.308265543540806, "Synovial cyst ": 12.2626082122909, "Synovitis ": 14.314795731591746, "Tendon disorder ": 10.059628227026568, "Tendonitis ": 3.6809391631386026, "Tenosynovitis ": 24.51529460698796, "Therapeutic product effect decreased ": 2.041337447852458, "Therapeutic product effect incomplete ": 2.7655217284640234, "Therapeutic response decreased ": 7.381814840207876, "Transaminases increased ": 2.040604695116417, "Treatment failure ": 3.3747016105962957, "Tuberculosis ": 6.595812314156319, "Upper respiratory tract infection ": 6.516649905179939, "White blood cell count abnormal ": 8.77558783836773, "White blood cell count decreased ": 2.102669778422348, "Wound ": 2.1858146496035933} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/65.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/65.json new file mode 100644 index 00000000000..3ad9238d3e3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/65.json @@ -0,0 +1 @@ +{"Application site erythema ": 527.973245072209, "Application site exfoliation ": 1032.0127431283329, "Application site haemorrhage ": 428.25188660894895, "Application site oedema ": 406.4519230286784, "Application site pain ": 126.01282470419216, "Application site pruritus ": 78.91465391185146, "Application site pustules ": 1764.2703490542085, "Application site reaction ": 97.91933944061462, "Application site scab ": 4173.279286329315, "Application site swelling ": 252.3272667956982, "Application site vesicles ": 160.43156103925915, "Erythema ": 3.146547926884322, "Off label use ": 10.961417770735672, "Pain ": 2.400725791329203, "Skin reaction ": 85.10522020518985, "Skin tightness ": 91.4880189362023} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/650.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/650.json new file mode 100644 index 00000000000..35c0fb3dcc7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/650.json @@ -0,0 +1 @@ +{"Acute respiratory distress syndrome ": 2.14872331314692, "Alopecia areata ": 10.662728972050672, "Anti-thyroid antibody ": 139.0987784470424, "Anti-thyroid antibody positive ": 314.36001348904705, "Ataxia ": 2.821490732818384, "Autoimmune disorder ": 2.389570673242441, "Autoimmune haemolytic anaemia ": 18.53816870563779, "Autoimmune hepatitis ": 7.082509170389333, "Autoimmune hypothyroidism ": 50.51961394119918, "Autoimmune thyroid disorder ": 128.67900246225378, "Autoimmune thyroiditis ": 53.83191282055074, "Bladder disorder ": 3.2882341622141644, "Blood lactate dehydrogenase increased ": 2.3838021859965823, "Blood thyroid stimulating hormone abnormal ": 120.05676553153154, "Blood thyroid stimulating hormone decreased ": 82.58039876066874, "Blood thyroid stimulating hormone increased ": 21.87378383907581, "Blood urine present ": 3.8282215603305447, "Bradycardia ": 7.211005267683478, "C-reactive protein increased ": 5.296766845676344, "CD4 lymphocytes decreased ": 16.80288543521944, "Central nervous system lesion ": 17.33789541689722, "Cervical dysplasia ": 11.28652655035136, "Cholecystitis ": 5.913156135792227, "Cholecystitis acute ": 11.907234357870486, "Contusion ": 2.273657855535961, "Diplopia ": 2.3831548823992024, "Drug exposure before pregnancy ": 93.84634169618052, "Drug monitoring procedure not performed ": 46.96732077351384, "Endocrine ophthalmopathy ": 63.33927446755166, "Expanded disability status scale score increased ": 95.20882108715216, "Flushing ": 2.732428192494343, "Gait disturbance ": 2.2492963836956643, "Gingival bleeding ": 3.653696064266547, "Goitre ": 8.874795237480754, "Goodpasture's syndrome ": 162.17114345446225, "Graves' disease ": 126.5616172045172, "Haematocrit decreased ": 5.632492966493451, "Haemoglobin decreased ": 2.188195330914495, "Haemolytic anaemia ": 5.458240986614634, "Haemophagocytic lymphohistiocytosis ": 2.4605507148224097, "Haemoptysis ": 2.8027649736590625, "Heart rate abnormal ": 3.132716376214324, "Heart rate decreased ": 3.256731081357765, "Heart rate increased ": 2.1619200581816465, "Heart rate irregular ": 2.82218354066066, "Hemiparesis ": 3.0226481991745717, "Hyperthermia ": 3.8821894342295913, "Hyperthyroidism ": 30.24331914374539, "Hypothyroidism ": 8.927005992463785, "Immune thrombocytopenia ": 44.39309954496417, "Immunosuppression ": 4.519662278784796, "Incorrect drug administration rate ": 24.46263347946997, "Incorrect product administration duration ": 4.583118031605791, "Increased appetite ": 2.0815903969135383, "Laboratory test abnormal ": 3.621720089890224, "Leukopenia ": 2.3327519725294192, "Listeria sepsis ": 131.10689916181974, "Listeriosis ": 79.30399236280809, "Liver function test increased ": 2.0608254237839514, "Lymphocyte count abnormal ": 158.77695140779184, "Lymphocyte count decreased ": 33.57313614709771, "Lymphocyte percentage decreased ": 99.34423702853086, "Lymphopenia ": 28.243206903670345, "Magnetic resonance imaging abnormal ": 87.63845247378052, "Malignant melanoma ": 2.0770975811767176, "Mean cell haemoglobin decreased ": 27.158257191841624, "Mean cell volume decreased ": 16.24632739922808, "Mean cell volume increased ": 11.551232672526217, "Meningitis listeria ": 143.63200416987397, "Monocyte count decreased ": 38.051814173734186, "Monocyte percentage decreased ": 200.10094088166096, "Mood altered ": 2.3721595954009, "Motor dysfunction ": 2.301005739984688, "Multiple sclerosis ": 17.257764784611222, "Multiple sclerosis relapse ": 56.60979159502951, "Muscle spasticity ": 5.679675875144048, "Muscular weakness ": 2.1324915017030937, "Neutrophil count abnormal ": 21.751065209396163, "Neutrophil count increased ": 10.015330921787124, "Neutrophil percentage increased ": 60.84889620006983, "Optic neuritis ": 5.323278433489317, "Paraparesis ": 11.096144810247372, "Petechiae ": 6.096998294941883, "Platelet count abnormal ": 17.11617574383416, "Platelet count decreased ": 4.016873737372585, "Pneumonitis ": 3.757755789756212, "Pregnancy ": 3.202600017487929, "Procalcitonin increased ": 18.29954473561047, "Progressive multifocal leukoencephalopathy ": 6.967018618871005, "Protein urine present ": 8.54560810210846, "Proteinuria ": 2.271459153916815, "Pulmonary alveolar haemorrhage ": 4.657545623267093, "Quadriplegia ": 7.709749894427327, "Rash ": 3.181336883524734, "Rash pruritic ": 3.209032709943617, "Red blood cell count decreased ": 3.370313038324932, "Red blood cells urine positive ": 46.67278921735836, "Red cell distribution width increased ": 9.218522099819216, "Sinus bradycardia ": 6.045703948241426, "Splenomegaly ": 2.048809668767644, "T-lymphocyte count decreased ": 50.23150163508888, "Temperature intolerance ": 14.926050538212602, "Thrombocytopenia ": 2.0969302628177644, "Thrombotic thrombocytopenic purpura ": 4.93918847614319, "Thyroid cancer ": 4.485956921005423, "Thyroid disorder ": 16.259927877650952, "Thyroid function test abnormal ": 21.82213989680832, "Thyroid hormones increased ": 23.09919146269037, "Thyroid mass ": 5.4845458589740215, "Thyroid stimulating immunoglobulin ": 1034.1950151487952, "Thyroidectomy ": 20.33452135401629, "Thyroiditis ": 16.653037045645465, "Thyroiditis subacute ": 12.853466586254806, "Thyroxine decreased ": 55.71555832429561, "Thyroxine free abnormal ": 302.5200800878616, "Thyroxine free decreased ": 57.15881881817646, "Thyroxine free increased ": 63.994883888, "Thyroxine increased ": 71.32546412355751, "Tri-iodothyronine free increased ": 105.4814836629793, "Tri-iodothyronine increased ": 79.89454199002692, "Tuberculosis ": 2.0179068586295537, "Type 1 diabetes mellitus ": 2.680401902852073, "Unevaluable event ": 3.5096739426359003, "Urinary sediment present ": 56.50905027710078, "Urinary tract infection ": 3.334893715605236, "Vitiligo ": 11.13938739947966, "White blood cell count abnormal ": 9.3182022126485, "White blood cell count increased ": 3.9596133054999454, "White blood cells urine positive ": 25.18015973754559} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/651.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/651.json new file mode 100644 index 00000000000..ea5fdf1506e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/651.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.1968264592693223, "Blood lactate dehydrogenase increased ": 8.256050239808985, "Cytokine release syndrome ": 7.979222337271628, "Cytopenia ": 13.47495918984489, "Diffuse large B-cell lymphoma ": 28.33090821670304, "Disease progression ": 17.15449841735862, "Febrile neutropenia ": 12.201021266757577, "Follicular lymphoma ": 145.17564843664542, "Infection ": 3.173961515205887, "Intentional product use issue ": 2.9335982464945336, "Malignant neoplasm progression ": 3.256936199165221, "Myelodysplastic syndrome ": 13.058060614436116, "Myelosuppression ": 10.146210653105106, "Neoplasm progression ": 4.284263797224767, "Neuropathy peripheral ": 2.5465568397602976, "Neutropenia ": 8.140339648451084, "Neutrophil count abnormal ": 82.10552000916098, "Neutrophil count decreased ": 6.0210835035711, "Off label use ": 6.297644749552972, "Plasma cell myeloma ": 15.03797815831158, "Platelet count abnormal ": 51.36176312677823, "Platelet count decreased ": 5.561125391079474, "Platelet disorder ": 160.24766203663197, "Pneumonia ": 4.173327347810318, "Rash maculo-papular ": 3.298335783450171, "Rash pruritic ": 2.6446630610189907, "Renal impairment ": 2.328058099474018, "Thrombocytopenia ": 4.261664046664009, "White blood cell count decreased ": 5.487689980223721} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/652.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/652.json new file mode 100644 index 00000000000..c0a27c3d83b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/652.json @@ -0,0 +1 @@ +{"Decreased appetite ": 2.591570654186314, "Hypertension ": 4.255357620400849, "Malignant neoplasm progression ": 10.076448626612216, "Palmar-plantar erythrodysaesthesia syndrome ": 21.372306069844967, "Product use in unapproved indication ": 4.71814602364193} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/653.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/653.json new file mode 100644 index 00000000000..31e28529c3a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/653.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 8.930942728376815, "Altered state of consciousness ": 2.4799665845552, "Ammonia increased ": 39.94253449630861, "Aortic dissection ": 20.651641066753616, "Arterial haemorrhage ": 34.065267325009586, "Ascites ": 11.947432428003705, "Aspartate aminotransferase increased ": 2.3196194220935644, "Blood albumin decreased ": 10.562859355633238, "Blood bilirubin increased ": 5.396399218810838, "Blood pressure increased ": 3.8734521482711983, "Blood thyroid stimulating hormone increased ": 14.456303508549514, "C-reactive protein increased ": 4.443000622909988, "Cardiac failure ": 4.314171500666581, "Cardiomyopathy ": 2.9012502879927835, "Cerebral haemorrhage ": 5.19294244221353, "Cerebral infarction ": 6.638697528789071, "Cholangitis ": 31.238836287333168, "Cholecystitis ": 23.69378658833244, "Cholecystitis acute ": 20.976946497177167, "Colitis ": 2.12685117337769, "Decreased appetite ": 11.40617200196008, "Dehydration ": 2.9445790959199454, "Diarrhoea ": 3.537950666911017, "Disseminated intravascular coagulation ": 2.846569099635216, "Drug eruption ": 2.1347704191464043, "Duodenal perforation ": 42.479587530942695, "Duodenal ulcer ": 4.282201277694157, "Duodenal ulcer haemorrhage ": 8.061933411146926, "Dysphonia ": 7.856109076067763, "Ejection fraction decreased ": 4.071966007755188, "Electrolyte imbalance ": 2.8846279584939047, "Encephalopathy ": 3.02890357611472, "Female genital tract fistula ": 4.233363004187082, "Fistula ": 31.70052200738032, "Gastric haemorrhage ": 2.6897151412464675, "Gastrointestinal perforation ": 40.12790119771768, "Generalised oedema ": 2.045157432292528, "Gingivitis ": 4.872605574255534, "Haematemesis ": 2.762349110647884, "Haemobilia ": 47.64103992779931, "Haemoptysis ": 4.824375820268939, "Hepatic encephalopathy ": 128.29548863085378, "Hepatic failure ": 8.739479561409487, "Hepatic function abnormal ": 5.5269270061868045, "Hyperaesthesia ": 6.203625348806715, "Hyperammonaemia ": 11.82633170608136, "Hypercalcaemia ": 2.2987456275342466, "Hypertension ": 13.802416264708938, "Hypertensive crisis ": 6.008694766639326, "Hyperthyroidism ": 2.9696860269319623, "Hypoalbuminaemia ": 4.647739014787701, "Hypocalcaemia ": 3.827131628437941, "Hypothyroidism ": 18.639165602739286, "Impaired healing ": 3.640410868017765, "Interstitial lung disease ": 4.972714864401161, "Intestinal perforation ": 11.51869585128959, "Jaundice ": 3.657477694873463, "Large intestine perforation ": 11.66486718706894, "Liver abscess ": 13.400039871420544, "Liver carcinoma ruptured ": 271.07394042044467, "Liver disorder ": 4.174418119128023, "Malignant neoplasm progression ": 7.298647799365376, "Mucosal inflammation ": 6.065694936931237, "Nephrotic syndrome ": 15.119008861741564, "Neutrophil count decreased ": 2.076983816420066, "Oedema ": 2.619798012002812, "Oedema peripheral ": 2.122636973033883, "Oesophageal varices haemorrhage ": 45.64002112013237, "Osteonecrosis of jaw ": 7.223543500335463, "Palmar-plantar erythrodysaesthesia syndrome ": 31.71208721746813, "Peritonitis ": 2.652979241113815, "Platelet count decreased ": 8.30307116506572, "Pleural effusion ": 2.925435608422407, "Pneumatosis intestinalis ": 12.528553601031517, "Pneumonia aspiration ": 2.722133455250781, "Pneumothorax ": 10.744055730438356, "Polycythaemia ": 27.482390398199648, "Portal vein thrombosis ": 16.95733373696746, "Posterior reversible encephalopathy syndrome ": 12.24705296816257, "Protein urine present ": 22.02907929843787, "Proteinuria ": 62.09274455717696, "Renal impairment ": 2.8982816678613945, "Skin ulcer ": 3.817334753552463, "Small intestinal perforation ": 26.649858926258048, "Stomatitis ": 6.3551049915749855, "Thyroiditis ": 6.217118023287381, "Tracheal fistula ": 526.8247248548116, "Transaminases increased ": 2.0898667479272723, "Tumour haemorrhage ": 84.89722879375826, "Tumour lysis syndrome ": 22.158735252069334, "Tumour rupture ": 53.60569918896044, "Upper gastrointestinal haemorrhage ": 2.0740997562694945, "Weight decreased ": 3.4954101867392464} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/654.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/654.json new file mode 100644 index 00000000000..164fd6d1e82 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/654.json @@ -0,0 +1 @@ +{"Myalgia ": 3.369100339840505} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/655.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/655.json new file mode 100644 index 00000000000..34dc22f7449 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/655.json @@ -0,0 +1 @@ +{"Hot flush ": 15.19712763704767, "Malignant neoplasm progression ": 8.509482013205686, "Prostate cancer ": 46.12833308098613, "Prostatic specific antigen increased ": 233.6534224817427} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/656.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/656.json new file mode 100644 index 00000000000..e66f54af7c3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/656.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 6.708010821351965, "Accident ": 2.2698265090541785, "Accidental overdose ": 2.731468809454636, "Anti-insulin antibody ": 60.51446007654668, "Anti-insulin antibody increased ": 42.24135693190912, "Anti-insulin antibody positive ": 65.54256120743777, "Arterial occlusive disease ": 4.452209429941644, "Blindness ": 4.996811570925369, "Blindness unilateral ": 5.340982813071396, "Blood glucose abnormal ": 15.898193397272356, "Blood glucose decreased ": 29.189055914170343, "Blood glucose fluctuation ": 49.34411776392753, "Blood glucose increased ": 32.632497950668935, "Blood ketone body ": 49.52114955389936, "Blood ketone body increased ": 12.435394888071787, "Blood ketone body present ": 33.404584010333835, "Caesarean section ": 2.5725167096039185, "Cardiac operation ": 8.343784117306644, "Cataract ": 7.6274511904606035, "Cataract operation ": 11.119449694123473, "Cerebrovascular accident ": 3.930474651540381, "Coronary arterial stent insertion ": 6.089964122745548, "Coronary artery bypass ": 2.6046800893845363, "Coronary artery occlusion ": 3.332643557418689, "Dementia ": 3.502844074267552, "Dementia Alzheimer's type ": 7.023380447787936, "Dermatitis allergic ": 2.033118901061256, "Device breakage ": 38.12530261797387, "Device defective ": 8.905525675249285, "Device delivery system issue ": 11.086550692073589, "Device failure ": 57.062834096024055, "Device information output issue ": 61.78094890984487, "Device issue ": 17.539454442666727, "Device leakage ": 9.967770233278, "Device malfunction ": 30.10624552781451, "Device mechanical issue ": 19.43946140360441, "Device occlusion ": 7.443442486982543, "Diabetes mellitus inadequate control ": 28.45367603973401, "Diabetic coma ": 23.696570480335687, "Diabetic complication ": 15.972291042383242, "Diabetic foot ": 20.344386665350797, "Diabetic hyperglycaemic coma ": 30.04175447263743, "Diabetic ketoacidosis ": 18.388140824666596, "Diabetic ketosis ": 18.22546555655237, "Diabetic metabolic decompensation ": 21.728037728530648, "Diabetic nephropathy ": 8.541939893518224, "Diabetic neuropathy ": 12.64338406508318, "Diabetic retinopathy ": 22.545218006903, "Dialysis ": 12.867675214138, "Disability ": 9.672015123887183, "Expired product administered ": 4.756628150636741, "Exposure during pregnancy ": 9.110907759417248, "Exposure via breast milk ": 3.895024508278608, "Extra dose administered ": 3.581489010946356, "Eye haemorrhage ": 3.070288391555473, "Eye operation ": 5.94635035443528, "Fall ": 2.108519059731171, "Foetal death ": 3.147920386783332, "Foetal distress syndrome ": 7.333661966332029, "Foetal exposure during pregnancy ": 8.898565197663387, "Foetal growth restriction ": 2.078601464502144, "Foetal macrosomia ": 41.43538494344274, "Gangrene ": 5.532445247267643, "Gastric dilatation ": 13.06417487450303, "Gestational hypertension ": 10.42982170893441, "Glaucoma ": 3.941069370397288, "Glycosylated haemoglobin abnormal ": 18.28899499981921, "Glycosylated haemoglobin decreased ": 16.062942918259004, "Glycosylated haemoglobin increased ": 18.864414336949903, "Hepatic cirrhosis ": 2.489053552219734, "Hip fracture ": 2.323481040538985, "Hospitalisation ": 3.679227575066503, "Hyperglycaemia ": 11.34060881009752, "Hyperglycaemic unconsciousness ": 88.43868834814944, "Hyperinsulinaemic hypoglycaemia ": 13.556973157449654, "Hypoglycaemia ": 23.534065387498018, "Hypoglycaemia neonatal ": 34.73321346683186, "Hypoglycaemia unawareness ": 35.38645981053781, "Hypoglycaemic coma ": 28.799798076918613, "Hypoglycaemic encephalopathy ": 20.251674391830758, "Hypoglycaemic seizure ": 42.525194626210286, "Hypoglycaemic unconsciousness ": 66.29622330524269, "Incorrect dose administered ": 2.441650830376014, "Incorrect dose administered by device ": 46.90545637174282, "Injection site atrophy ": 93.30764804742874, "Injection site bruising ": 9.22956943458334, "Injection site discolouration ": 8.485966240901787, "Injection site erythema ": 4.857376712430522, "Injection site extravasation ": 4.395854657437314, "Injection site haemorrhage ": 3.2031583462315405, "Injection site hypersensitivity ": 44.45499172669084, "Injection site hypertrophy ": 48.60182647065912, "Injection site induration ": 11.30649294693091, "Injection site mass ": 23.58107779973397, "Injection site nodule ": 12.987068176609336, "Injection site oedema ": 4.433314725857291, "Injection site pruritus ": 8.740300564584297, "Injection site rash ": 10.97844969449756, "Injection site reaction ": 4.114331596347724, "Injection site swelling ": 2.0640411473575746, "Injection site urticaria ": 27.167168800624683, "Insulin resistance ": 14.961892558651355, "Intentional dose omission ": 6.966707818988658, "Intervertebral disc protrusion ": 2.1369276490123568, "Jaundice neonatal ": 41.368028329314974, "Ketoacidosis ": 6.9490218930578544, "Knee operation ": 5.214745948474147, "Leg amputation ": 17.19800812639043, "Lipoatrophy ": 21.88253394069027, "Lipodystrophy acquired ": 10.242424622805435, "Lipohypertrophy ": 22.755453490831044, "Liquid product physical issue ": 9.255694770450212, "Localised infection ": 7.943715523025998, "Low birth weight baby ": 3.629158159883025, "Lower limb fracture ": 3.144520046999083, "Macular degeneration ": 4.952040199595427, "Maternal exposure during pregnancy ": 6.406750246669916, "Myocardial infarction ": 2.7526349727555184, "Needle issue ": 2.6686461125603103, "Neonatal respiratory distress syndrome ": 6.966338753399174, "Neoplasm malignant ": 2.4395184968672896, "Osteomyelitis ": 2.376699498403231, "Pancreatic carcinoma ": 2.6328489590195447, "Parkinson's disease ": 2.080299468795502, "Post procedural haemorrhage ": 2.0661060150427715, "Pre-eclampsia ": 19.20793612579897, "Pregnancy ": 3.3106054400373, "Premature baby ": 12.03020437085858, "Premature delivery ": 9.660720204820374, "Premature labour ": 3.151873147420036, "Product administration error ": 2.470478097143442, "Product communication issue ": 20.14782096978226, "Product container issue ": 17.11373965462868, "Product dispensing error ": 4.630873659602108, "Product leakage ": 7.794624856468626, "Product physical issue ": 10.355565363942771, "Product quality issue ": 10.178689697245726, "Product storage error ": 11.31339515297005, "Product use complaint ": 5.06773272916548, "Renal disorder ": 2.3261728046523658, "Renal transplant ": 7.9629372065228194, "Respiratory disorder neonatal ": 29.521348740205312, "Retinopathy ": 5.4030603618121535, "Road traffic accident ": 3.0535359425482933, "Shock hypoglycaemic ": 11.670328721241091, "Skin reaction ": 3.3825724115326827, "Skin ulcer ": 3.069922889751004, "Sopor ": 2.267081193228252, "Spinal operation ": 2.087569562098111, "Spinal stenosis ": 3.1765705964814805, "Staphylococcal infection ": 2.172171688203573, "Stent placement ": 2.9597525650870518, "Stillbirth ": 4.949026992548856, "Surgery ": 3.09334220537124, "Toe amputation ": 19.544256783098888, "Treatment noncompliance ": 3.863995959109338, "Ventricular septal defect ": 4.34426985822138, "Weight increased ": 2.068116296010535, "Wheelchair user ": 5.280469474473868, "Wrong product administered ": 19.17303623246681, "Wrong technique in product usage process ": 2.536656019225945} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/657.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/657.json new file mode 100644 index 00000000000..39b5844e64d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/657.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 6.499697901118006, "Abortion induced ": 3.8912446113691455, "Abortion spontaneous ": 4.061530013123205, "Acidosis hyperchloraemic ": 440.4716700362024, "Acute generalised exanthematous pustulosis ": 2.915635530766832, "Acute hepatic failure ": 4.581103047247436, "Acute psychosis ": 12.312738919978113, "Adverse drug reaction ": 2.524222450790091, "Affect lability ": 5.242873019592547, "Affective disorder ": 7.737605801786861, "Aggression ": 12.187562621272214, "Agitation ": 3.474589138694722, "Altered state of consciousness ": 2.281512622524628, "Ammonia increased ": 7.289186730475309, "Anger ": 5.159217232548572, "Anticonvulsant drug level above therapeutic ": 30.799991497847827, "Anticonvulsant drug level below therapeutic ": 33.849691263280874, "Anticonvulsant drug level decreased ": 21.300144797851804, "Anticonvulsant drug level increased ": 12.941280590671036, "Anxiety disorder ": 3.872946813867824, "Apathy ": 3.215824000145393, "Apnoea ": 3.6717342005658433, "Apnoeic attack ": 14.029602172204472, "Aspiration ": 2.954466996728858, "Asterixis ": 20.13979989690805, "Ataxia ": 12.452946068832151, "Atonic seizures ": 45.35319020774524, "Atrial septal defect ": 3.719095114159988, "Atrioventricular block first degree ": 2.115235232549741, "Atrioventricular block second degree ": 2.207083209496211, "Atrophy ": 7.871720056272367, "Attention deficit hyperactivity disorder ": 5.210961635223912, "Aura ": 16.286123382144673, "Autism spectrum disorder ": 2.5115092688028566, "Autonomic nervous system imbalance ": 2.060579054294554, "Behaviour disorder ": 24.082626939401504, "Blood chloride increased ": 104.64334134233098, "Blood pH decreased ": 92.12923947398713, "Bradyarrhythmia ": 4.518278149119372, "Bradycardia foetal ": 4.348513057783526, "Bradyphrenia ": 3.5875613242267845, "Bradypnoea ": 2.3146938810641284, "Bronchiolitis ": 2.2402039333998998, "Cachexia ": 4.305684461103573, "Caesarean section ": 2.828039017847453, "Cardiopulmonary failure ": 3.732807184881615, "Cerebral atrophy ": 4.044566570875708, "Cerebral disorder ": 2.050262731303567, "Change in seizure presentation ": 33.00445893528884, "Cholestatic liver injury ": 5.056525154829041, "Cleft palate ": 3.658521851593559, "Clonic convulsion ": 20.53755957175016, "Clonus ": 2.4512112549588068, "Cognitive disorder ": 5.90983230436221, "Completed suicide ": 2.8115928000046866, "Condition aggravated ": 2.5681435723474646, "Congenital anomaly ": 4.2729897688882055, "Conjunctival hyperaemia ": 2.1527398136336577, "Coordination abnormal ": 3.885656072407611, "Culture urine positive ": 20.55012709141713, "Delirium ": 2.2967244584468376, "Delusion ": 7.289089776186576, "Depressed mood ": 2.294681625794916, "Depression ": 2.1160099814550777, "Depressive symptom ": 2.2593546973045444, "Dermatitis allergic ": 2.295182024544755, "Developmental delay ": 5.288146215482204, "Developmental hip dysplasia ": 17.14280969596731, "Diabetic neuropathy ": 4.293904056210915, "Disease recurrence ": 2.780853434363451, "Drooling ": 3.07628284858598, "Drop attacks ": 15.394828611129451, "Drug effective for unapproved indication ": 2.6453370919791683, "Drug eruption ": 2.147818082036029, "Drug ineffective ": 5.939343527639412, "Drug ineffective for unapproved indication ": 8.978242273934653, "Drug interaction ": 3.046341243010516, "Drug level below therapeutic ": 4.758191441114706, "Drug level decreased ": 7.498197467674996, "Drug level increased ": 2.8144704735512738, "Drug reaction with eosinophilia and systemic symptoms ": 13.917262267872736, "Drug resistance ": 15.653016394293587, "Drug withdrawal convulsions ": 8.602827307342709, "Dyskinesia ": 2.775534225488941, "Dysmorphism ": 6.939375777940857, "Electroencephalogram abnormal ": 20.781853516182707, "Electrolyte imbalance ": 2.140458865779392, "Emotional disorder ": 2.2513120162268887, "Encephalitis autoimmune ": 16.196939528440094, "Encephalopathy ": 3.5538455699192246, "Eosinophilia ": 3.857571960361709, "Eosinophilic cystitis ": 128.51419354834565, "Epilepsia partialis continua ": 65.6393091691687, "Epilepsy ": 16.666419495506936, "Epileptic encephalopathy ": 111.82760703308053, "Euphoric mood ": 2.157143875984096, "Excessive eye blinking ": 12.077227753748533, "Exposure during pregnancy ": 2.7279511649259867, "Feeling of despair ": 2.139695809851041, "Focal dyscognitive seizures ": 50.58469381913426, "Foetal distress syndrome ": 3.0915571262775283, "Foetal exposure during pregnancy ": 5.635095960703141, "Foetal growth restriction ": 2.788827944786607, "Foetal malformation ": 18.912685862336, "Gastrointestinal hypomotility ": 14.053173956490076, "Generalised tonic-clonic seizure ": 17.398498038491827, "Gingival hypertrophy ": 8.952639175588828, "Haemangioma ": 7.876656868223224, "Haemodynamic instability ": 5.880561818582035, "Haemophagocytic lymphohistiocytosis ": 3.036925348731608, "Hallucination, auditory ": 2.837230167116293, "Hallucination, visual ": 3.391483978688039, "Hallucinations, mixed ": 7.0931842792459125, "Hostility ": 7.656645987949806, "Hydrocephalus ": 3.035015014493942, "Hyperammonaemia ": 9.003340065181149, "Hyperammonaemic encephalopathy ": 14.164951703507915, "Hypercapnia ": 3.568336968158876, "Hypernatraemia ": 3.493030303050896, "Hyperreflexia ": 3.1893209471104256, "Hypersexuality ": 5.959144632861045, "Hypertransaminasaemia ": 3.644663696860511, "Hypertrophic cardiomyopathy ": 22.06533167375348, "Hypoglycaemia neonatal ": 4.509074734901488, "Hypomagnesaemia ": 7.557550461647026, "Hyponatraemia ": 2.491222663930421, "Hyporeflexia ": 2.5758231206481925, "Hypotonia ": 3.652039108564368, "Hypotonia neonatal ": 12.020981570990903, "Impulsive behaviour ": 10.038878560968842, "Inappropriate antidiuretic hormone secretion ": 2.180918036870101, "Incorrect route of product administration ": 2.565387640515437, "Increased bronchial secretion ": 3.764786053933884, "Infantile spasms ": 45.33390919673814, "Intellectual disability ": 15.112956368947549, "Intestinal ischaemia ": 2.0691279262923548, "Intestinal perforation ": 3.904256428394869, "Intra-abdominal pressure increased ": 228.95562461413263, "Iodine allergy ": 22.82760212343091, "Irritability ": 7.3781793056509715, "Language disorder ": 5.664683744393851, "Left ventricular hypertrophy ": 2.6927629518092417, "Leukocytosis ": 2.018622219861783, "Low birth weight baby ": 5.970938335265829, "Major depression ": 4.97187036849143, "Malabsorption ": 2.7857197542984866, "Mania ": 2.0401322781360087, "Mastication disorder ": 4.160746158167752, "Maternal exposure before pregnancy ": 8.056050921382376, "Maternal exposure during pregnancy ": 4.624810248682817, "Memory impairment ": 2.415526318538046, "Mental disorder ": 2.439086821822709, "Mental status changes ": 4.058162025087208, "Metabolic acidosis ": 2.5634366948375056, "Metabolic encephalopathy ": 6.244520019860818, "Mitochondrial DNA mutation ": 48.901741466100425, "Mood altered ": 5.388692778598893, "Mood swings ": 3.505062928250133, "Motor dysfunction ": 3.2781991690739973, "Multiple organ dysfunction syndrome ": 2.963596066497437, "Multiple-drug resistance ": 108.75641881042888, "Muscle twitching ": 2.412541363672651, "Myoclonic epilepsy ": 62.927670597876926, "Myoclonus ": 10.287496522898865, "Necrosis 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2.750252117852118, "Supraventricular tachycardia ": 2.713556338607779, "Suspected suicide ": 8.528941382301895, "Systemic inflammatory response syndrome ": 8.421576799876128, "Talipes ": 5.463303368911634, "Temporal lobe epilepsy ": 15.916514601487258, "Teratogenicity ": 34.61988502289864, "Therapeutic product effect incomplete ": 3.3942691420320785, "Therapeutic response changed ": 10.204610223234935, "Therapeutic response decreased ": 2.496085329388006, "Therapy cessation ": 2.247097765317061, "Therapy non-responder ": 3.371514786742034, "Thinking abnormal ": 3.386492143518465, "Tongue disorder ": 2.2281372618864235, "Tonic convulsion ": 33.059397324019265, "Toxic encephalopathy ": 3.5640887841101803, "Toxic epidermal necrolysis ": 6.027602506804378, "Toxicity to various agents ": 2.8515691580952884, "Treatment failure ": 2.6931910484583472, "Treatment noncompliance ": 2.425354681140929, "Tubulointerstitial nephritis ": 4.359245735523142, "Unresponsive to stimuli ": 2.125079441636542, "Ventricular septal defect ": 6.312468236404844, "Weight fluctuation ": 2.1132996425311807, "Wrong patient received product ": 2.218197256067405} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/658.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/658.json new file mode 100644 index 00000000000..28be03de92d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/658.json @@ -0,0 +1 @@ +{"Malignant melanoma ": 100.69410941559936, "Malignant melanoma in situ ": 326.721474720663, "Vision blurred ": 8.44443590716779} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/659.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/659.json new file mode 100644 index 00000000000..1e0e5a7ff58 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/659.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 3.506483117110069, "Accidental overdose ": 2.822563514884808, "Aggression ": 2.058743224429961, "Agitation ": 3.450032634703039, "Akinesia ": 72.04836978935596, "Anxiety ": 2.382816806697764, "Apathy ": 14.09673920175693, "Balance disorder ": 2.636679247003219, "Behaviour disorder ": 5.929558998271033, "Blood creatine phosphokinase increased ": 2.4012481087550515, "Bradykinesia ": 35.247123554883295, "Cognitive disorder ": 4.37768256367095, "Completed suicide ": 2.3224432487173647, "Compulsive shopping ": 252.64324083253203, "Condition aggravated ": 2.567978954563276, "Delirium ": 4.631684178419766, "Delusion ": 19.5775776476232, "Dementia ": 3.374356363861173, "Depressed mood ": 2.7511959485787765, "Depression ": 2.9537147464829743, "Dopamine dysregulation syndrome ": 2264.228123339601, "Drug abuse ": 3.159321513760441, "Drug dependence ": 3.5291502802900347, "Drug 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3.0533610105981435, "Jealous delusion ": 617.832767470861, "Labelled drug-disease interaction issue ": 1272.462204249185, "Mood altered ": 4.0301309454851015, "Motor dysfunction ": 10.732357297884976, "Movement disorder ": 7.844531657826774, "Muscle rigidity ": 16.405095550951703, "Myoclonus ": 10.331335123572996, "Neuroleptic malignant syndrome ": 17.41257569686684, "Obsessive-compulsive disorder ": 14.00328034366333, "On and off phenomenon ": 850.806344389586, "Oromandibular dystonia ": 128.2575176357359, "Orthostatic hypotension ": 8.590013370322712, "Overdose ": 2.327211917401294, "Paranoia ": 12.369932604489309, "Paraphilia ": 980.963496440671, "Parkinson's disease ": 47.02115758391009, "Parkinsonian gait ": 161.27818397582072, "Parkinsonism ": 38.09030227816618, "Product administration error ": 2.644137164702144, "Psychotic disorder ": 10.037793525066412, "Restlessness ": 3.786902530408209, "Somnolence ": 2.4987852500368537, "Speech disorder ": 4.789574844356002, "Stereotypy ": 185.73751418975763, "Therapeutic response shortened ": 176.43122478116686, "Tremor ": 2.4738617204574243, "Withdrawal syndrome ": 4.537739524851074} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/66.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/66.json new file mode 100644 index 00000000000..2f5ffb3a4a0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/66.json @@ -0,0 +1 @@ +{"Abdominal pain ": 4.005379349207265, "Anaphylactic reaction ": 14.08493008854426, "Ankylosing spondylitis ": 86.78172966017884, "Asthenia ": 2.602966987063198, "Crohn's disease ": 25.94744480358513, "Diarrhoea ": 2.184398709408377, "Drug ineffective ": 4.702831812860649, "Drug intolerance ": 12.137867889216734, "Dry eye ": 95.73546858846136, "General symptom ": 717.8213894303317, "Inflammation ": 22.37178063566425, "Lacrimation increased ": 90.57457375383964, "Loss of personal independence in daily activities ": 17.46137590846161, "Oedema ": 17.355048168592948, "Pain in extremity ": 2.3360798188649907, "Pelvic pain ": 121.14916487980284, "Plantar fasciitis ": 1020.8310174406388, "Psoriasis ": 46.48257774633006, "Synovitis ": 50.74562628472639, "Tendonitis ": 103.15099803175072, "Therapeutic product effect incomplete ": 16.622980979336923, "Therapy non-responder ": 24.78416704670003} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/660.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/660.json new file mode 100644 index 00000000000..696a311129b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/660.json @@ -0,0 +1 @@ +{"Acute generalised exanthematous pustulosis ": 3.1864692528153307, "Acute myelomonocytic leukaemia ": 19.9330575042766, "Acute psychosis ": 4.078748428537944, "Acute respiratory distress syndrome ": 2.114842279257867, "Alanine aminotransferase abnormal ": 2.2072020919878814, "Alanine aminotransferase increased ": 2.170821670450734, "Anaphylactic shock ": 2.86058351795023, "Anaphylactoid reaction ": 4.339935132695832, "Anion gap increased ": 6.3262374118929445, "Anterior chamber cell ": 4.331710579190829, "Anterior chamber flare ": 14.988135685507585, "Aspartate aminotransferase increased ": 2.251674175645048, "Aspergillus infection ": 2.240465102232472, "Autoimmune haemolytic anaemia ": 2.2586392446645185, "Azotaemia ": 2.0010674817089877, "Bacteraemia ": 3.442758052709024, "Balance disorder ": 13.24243098999399, "Blood calcium decreased ": 88.41403438728841, "Blood calcium increased ": 2.6597231874285816, "Blood lactate dehydrogenase increased ": 2.100154410227628, "Brain abscess ": 2.959564359518636, "Breath sounds abnormal ": 2.6193228652632774, "Cardiac tamponade ": 3.3419244869663847, "Clostridium colitis ": 11.969164167580772, "Clostridium difficile colitis ": 7.428796671954979, "Clostridium difficile infection ": 5.886259591739354, "Coagulation time prolonged ": 2.233926540903445, "Coagulopathy ": 3.287296278170556, "Cognitive disorder ": 24.327299973212217, "Compartment syndrome ": 2.7846165817060897, "Conjunctival hyperaemia ": 3.310148512940972, "Constipation ": 6.582306371412972, "Corneal oedema ": 4.428008563993886, "Corneal perforation ": 15.140872343756246, "Coronavirus test positive ": 7.502933792716737, "Creatinine renal clearance decreased ": 119.66811580070424, "Creatinine renal clearance increased ": 99.70604777908396, "Cross sensitivity reaction ": 5.449939383665131, "Crystal nephropathy ": 33.98188359258177, "Delirium ": 2.434575165138333, "Depressed level of consciousness ": 14.044451354883655, "Dermatitis ": 2.5236922347929607, "Dermatitis allergic ": 2.447716675410443, "Dermatitis exfoliative ": 2.669590634810534, "Disorganised speech ": 8.736299620696448, "Disseminated intravascular coagulation ": 2.343900830570764, "Disseminated tuberculosis ": 11.563651539049122, "Drug eruption ": 5.227316988337027, "Drug hypersensitivity ": 2.875681206602871, "Drug ineffective for unapproved indication ": 2.230452642797883, "Drug interaction ": 3.594661829181225, "Drug reaction with eosinophilia and systemic symptoms ": 4.455676240844641, "Drug resistance ": 5.016391771274482, "Drug-induced liver injury ": 5.521010801650552, "Dysbiosis ": 20.051264052504667, "Dysphoria ": 2.072709770882443, "Electrocardiogram QT prolonged ": 9.18930901746827, "Endophthalmitis ": 3.4991728629313754, "Eosinophil count increased ": 2.4818682441324733, "Eosinophilic pneumonia ": 4.489157053681913, "Eosinophilic pneumonia acute ": 7.28086587239545, "Epidermal necrosis ": 9.238672864122984, "Erythema multiforme ": 2.613513015709456, "Erythema nodosum ": 2.1353646994259643, "Erythema of eyelid ": 2.370244644901882, "Escherichia infection ": 3.311533091880843, "Face oedema ": 2.3360535632735577, "Fall ": 4.503090774256149, "Fibrin ": 281.83310809847814, "Fixed eruption ": 14.22100656015794, "Gastrointestinal motility disorder ": 4.399158594160427, "Granulocytopenia ": 2.5016452355849217, "Haemodynamic instability ": 4.813153597234976, "Haemorrhage urinary tract ": 2.1935999456022794, "Hallucination, visual ": 2.511103063728401, "Henoch-Schonlein purpura ": 2.1935999456022794, "Hepatic function abnormal ": 4.947155426804847, "Hepatitis acute ": 4.616759946338017, "Hepatitis toxic ": 2.9231998092304585, "Hepatocellular injury ": 2.52802188802698, "Hepatosplenomegaly ": 2.767922001183315, "Hepatotoxicity ": 2.7849205834653707, "Hyperaemia ": 7.255328752525575, "Hypersensitivity myocarditis ": 16.7442650482528, "Hypersensitivity vasculitis ": 3.4949224392947262, "Hypocoagulable state ": 7.724384290183256, "Hypomagnesaemia ": 3.0398567391453235, "Hypotension ": 4.263501885935338, "Hypovolaemic shock ": 3.105191578016871, "Infusion site erythema ": 5.242558021484332, "Infusion site phlebitis ": 15.2608525292957, "Infusion site pruritus ": 6.848978721640928, "International normalised ratio increased ": 3.105523449470476, "Joint noise ": 4.902634522660343, "Keratitis fungal ": 34.7178714916898, "Keratopathy ": 15.475580989096027, "Klebsiella infection ": 3.361512230636813, "Kounis syndrome ": 5.746158934209714, "Laryngeal oedema ": 3.267134094336276, "Leukocytosis ": 3.2606389958573483, "Lip oedema ": 2.899415331434075, "Liver injury ": 3.259464455551239, "Long QT syndrome ": 9.006782357675878, "Lung consolidation ": 6.1215352835389965, "Lymphocyte morphology abnormal ": 6.7073626316054105, "Macule ": 6.507771537663624, "Megacolon ": 7.53600144829206, "Meniscus injury ": 2.309812339610075, "Methaemoglobinaemia ": 11.068121497177764, "Mobility decreased ": 12.775584031504165, "Mucormycosis ": 3.066830280521802, "Multiple drug therapy ": 165.60940022887206, "Multiple organ dysfunction syndrome ": 3.0914899425731117, "Muscle discomfort ": 2.2214024857031087, "Muscle rupture ": 4.859420718124301, "Musculoskeletal injury ": 24.027052810713418, "Myoclonic epilepsy ": 2.6898893096576564, "Myopathy ": 2.014961036992792, "Nervous system disorder ": 2.07662505610088, "Neuropathy peripheral ": 2.7071694875020658, "Neutrophilia ": 2.789243798216206, "Nocardiosis ": 4.134828548791761, "Ocular icterus ": 2.935330170742204, "Off label use ": 2.2661199625667563, "Oliguria ": 5.929156138332552, "Orthostatic hypotension ": 38.08930896055659, "Oxygen saturation abnormal ": 4.117386491830603, "Painful ejaculation ": 53.04212209328095, "Palatal oedema ": 2.939626795196689, "Papule ": 2.499594359053298, "Paradoxical drug reaction ": 3.201428477403569, "Paranasal sinus inflammation ": 20.41497334503136, "Pathogen resistance ": 26.729323661118897, "Perineal pain ": 20.51317719429193, "Peripheral nerve injury ": 10.267746259537336, "Phlebitis ": 2.3874963180274995, "Plantar fasciitis ": 5.184190944825141, "Pneumocystis jirovecii pneumonia ": 2.092981062109333, "Pneumonia fungal ": 3.204626735886338, "Polymerase chain reaction positive ": 24.851458710209272, "Procalcitonin increased ": 5.82542853068188, "Prostatitis ": 2.6023625805693267, "Prothrombin time prolonged ": 3.934026653098589, "Prurigo ": 8.361147565363211, "Pruritus ": 2.312981168595094, "Pseudomembranous colitis ": 15.050348217150509, "Pseudomonas infection ": 4.15307960907002, "Pulmonary tuberculosis ": 4.925521034088022, "Purulent discharge ": 3.204513227314988, "Rash ": 2.0508538044839786, "Rash erythematous ": 2.997936605009793, "Rash maculo-papular ": 2.2374429924409056, "Renal function test abnormal ": 32.89275412285276, "Rhabdomyolysis ": 2.5545417796052305, "Rotator cuff syndrome ": 6.561657491677472, "Sedation ": 39.63139972347844, "Sedation complication ": 147.98221380379042, "Septic shock ": 3.405249312886684, "Skin erosion ": 2.2600491902214683, "Skin hyperpigmentation ": 3.136375666034769, "Skin infection ": 2.540034895548595, "Skin injury ": 5.488724777352484, "Sputum purulent ": 12.080150604444048, "Staphylococcal sepsis ": 2.4402485822393976, "Stenotrophomonas infection ": 6.038687055799206, "Stevens-Johnson syndrome ": 4.659642703872933, "Subcutaneous abscess ": 2.379752553670076, "Substance-induced psychotic disorder ": 6.24603698637604, "Tachypnoea ": 3.214377005780406, "Temperature intolerance ": 3.85459657672525, "Tendon discomfort ": 32.8117707554745, "Tendon disorder ": 27.97803066450283, "Tendon injury ": 20.835173229723043, "Tendon pain ": 50.72076838887962, "Tendon rupture ": 40.73205725739816, "Tendonitis ": 45.89371335963192, "Tenosynovitis ": 4.4358294418715785, "Torsade de pointes ": 10.294226857991136, "Toxic epidermal necrolysis ": 6.668429993556349, "Toxicity to various agents ": 5.370332413921644, "Transaminases increased ": 2.544695318097428, "Tuberculosis ": 3.663185332935721, "Tubulointerstitial nephritis ": 5.31491647360492, "Type I hypersensitivity ": 9.03871718309368, "Ventricular tachycardia ": 2.695293217748934} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/661.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/661.json new file mode 100644 index 00000000000..a3ff0555701 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/661.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 12.824907575127687, "Colitis ": 6.518087400409695, "Death ": 2.7703912850880985, "Disease progression ": 12.637190316052566, "General physical health deterioration ": 4.029651328218883, "Hepatitis ": 7.803725110597868, "Hyperthyroidism ": 7.8545021524085055, "Hypothyroidism ": 16.56030425450857, "Interstitial lung disease ": 2.6902250626939685, "Malignant neoplasm progression ": 3.3511231171771247, "Myocarditis ": 6.679995533611112, "Myositis ": 24.899890572959738, "Neoplasm malignant ": 4.139028660434776, "Pemphigoid ": 24.370993007234965, "Pneumonitis ": 22.17963797527833, "Sepsis ": 2.984409222436762, "Squamous cell carcinoma of skin ": 71.47440420971948, "Type 1 diabetes mellitus ": 15.369091241456855} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/662.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/662.json new file mode 100644 index 00000000000..ef1d0355add --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/662.json @@ -0,0 +1 @@ +{"Cardiac arrest ": 71.16291199317672, "Cardio-respiratory arrest ": 35.994679443483, "Cerebrospinal fluid leakage ": 1023.2319110132846, "Completed suicide ": 87.47891839413673, "Death ": 5.5917204316085, "Implant site discharge ": 6734.374033975497, "Implant site extravasation ": 2690.8813664238464, "Muscle spasms ": 10.485525791662669, "Muscle spasticity ": 143.13476011750578, "Off label use ": 2.1547763096872536, "Suspected suicide ": 138.874140685055, "Therapeutic response decreased ": 44.45792970260735, "Toxicity to various agents ": 26.95828309183875} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/663.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/663.json new file mode 100644 index 00000000000..9a000b14ccb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/663.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 4.33109409472652, "Drug interaction ": 5.767175390918242, "Fall ": 2.930234974354311, "Hypoglycaemia ": 14.510139571270685, "Pemphigoid ": 60.263806054218286} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/664.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/664.json new file mode 100644 index 00000000000..1ee07009a64 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/664.json @@ -0,0 +1 @@ +{"Blood glucose abnormal ": 53.4575286452238, "Blood glucose fluctuation ": 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/666.json new file mode 100644 index 00000000000..881e86f7f06 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/666.json @@ -0,0 +1 @@ +{"Cytokine release syndrome ": 608.0119262676772, "Pyrexia ": 3.739803912703095} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/667.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/667.json new file mode 100644 index 00000000000..26d08aaf1b9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/667.json @@ -0,0 +1 @@ +{"Cutaneous vasculitis ": 84.4335224071629, "Hyperbilirubinaemia ": 45.972828608775394, "Neutropenia ": 4.505284177980844, "Off label use ": 3.0732478353406427, "Pruritus ": 2.360138812538991, "Rash ": 3.431970488380247, "Rash maculo-papular ": 72.23912974591937, "Toxic skin eruption ": 80.85767479288174} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/668.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/668.json new file mode 100644 index 00000000000..9e26dfeeb6e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/668.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/669.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/669.json new file mode 100644 index 00000000000..af4c52df716 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/669.json @@ -0,0 +1 @@ +{"Death ": 6.995540191090403} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/67.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/67.json new file mode 100644 index 00000000000..4f991064141 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/67.json @@ -0,0 +1 @@ +{"Abscess ": 7.868278144604589, "Abscess limb ": 23.63360683482409, "Acinetobacter infection ": 95.3788230832942, "Acoustic neuroma ": 89.69608075187472, "Acute generalised exanthematous pustulosis ": 5.658988385009125, "Acute kidney injury ": 4.214671752057169, "Alanine aminotransferase increased ": 2.8693614475672438, "Anticoagulation drug level above therapeutic ": 38.4740518413227, "Anuria ": 4.178088750542549, "Anxiety disorder ": 9.656380191759064, "Aspergillus infection ": 18.113661635648967, "Ataxia ": 2.071857426826283, "Atypical mycobacterial infection ": 45.750479287930375, "Atypical mycobacterium test positive ": 534.8625835358554, "Bacterial infection ": 4.606451117559942, "Blood albumin decreased ": 6.092170882102, "Brain abscess ": 26.55995398593603, "Bronchiectasis ": 10.289576518451682, "Bronchopulmonary aspergillosis ": 6.186924017394556, "Cachexia ": 9.841647946733753, "Candida infection ": 19.01015777720368, "Cheilitis ": 8.653335205272196, "Clostridium difficile colitis ": 19.65318733007692, "Clostridium difficile infection ": 4.058652063326903, "Condition aggravated ": 3.7208174939073615, "Congenital aplasia ": 28.562420385438894, "Cytomegalovirus infection ": 2.975346064102555, "Cytopenia ": 3.585680219840901, "Deafness ": 20.19182224680455, "Deafness bilateral ": 28.48454022944031, "Deafness neurosensory ": 49.65664319903518, "Depressive symptom ": 9.404026951051693, "Dermatitis ": 2.127572083275284, "Dermatitis exfoliative generalised ": 5.746425597486221, "Disease recurrence ": 6.960585413412245, "Disseminated mycobacterium avium complex infection ": 179.9172786839936, "Drug ineffective ": 3.25706331027822, "Drug ineffective for unapproved indication ": 7.270823552460221, "Drug intolerance ": 3.8688369079297513, "Drug reaction with eosinophilia and systemic symptoms ": 19.39997331861376, "Drug 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5.232923293963265, "Hyperbilirubinaemia ": 4.180003636970371, "Hyperlactacidaemia ": 15.303986672376556, "Hypoacusis ": 5.5624242736819625, "Hypoalbuminaemia ": 6.738321961176094, "Hypogammaglobulinaemia ": 13.352707042156537, "Hypomagnesaemia ": 4.913407135136728, "Hypoproteinaemia ": 26.12155459479332, "Hypoxia ": 4.797577679130017, "Immune reconstitution inflammatory syndrome ": 6.272124571394586, "Inflammatory marker increased ": 14.389638833673551, "Intentional product use issue ": 3.1424090786547647, "Klebsiella infection ": 95.87163851363572, "Leukocytosis ": 3.0157308620725773, "Leukopenia ": 2.658030388210914, "Liver abscess ": 15.503320153638995, "Lung transplant rejection ": 86.75445446744452, "Lymphadenitis ": 2.9672722226590413, "Lymphopenia ": 3.1734161064888395, "Metabolic acidosis ": 3.01167565933921, "Microangiopathic haemolytic anaemia ": 70.77640694401363, "Moraxella infection ": 234.4438383409893, "Mucormycosis ": 25.668700284221813, "Multiple organ dysfunction syndrome ": 7.609418994484369, "Multiple-drug resistance ": 9.484347282901172, "Mycobacterial infection ": 51.05499789923144, "Mycobacterium abscessus infection ": 644.3524522687882, "Mycobacterium avium complex infection ": 208.6702244361007, "Neonatal candida infection ": 1321.3792121936094, "Nephropathy toxic ": 18.60198113024841, "Neuropathy peripheral ": 2.56030194212509, "Nodule ": 4.606356276354017, "Off label use ": 2.241205505901953, "Oliguria ": 4.12182206682986, "Optic neuritis ": 8.628884490105358, "Otitis media ": 9.069150587417631, "Ototoxicity ": 275.40436637700014, "Pancytopenia ": 2.3218026713617226, "Pathogen resistance ": 47.53185946752846, "Pleurisy ": 6.735529907934369, "Polyp ": 8.723592742098521, "Product prescribing error ": 4.222294779045326, "Product use in unapproved indication ": 3.434552160653675, "Proteus infection ": 120.9803622922906, "Pseudomembranous colitis ": 6.97841915403745, "Pseudomonas infection ": 22.172232147919782, "Pulmonary cavitation ": 49.7260167254742, "Pulmonary haemorrhage ": 11.089191250638232, "Pulmonary mass ": 5.923889203078185, "Pyelonephritis ": 4.239618964789491, "Rash erythematous ": 2.219900181749688, "Rash maculo-papular ": 8.859653169574724, "Rash morbilliform ": 2.793935905518331, "Red blood cell sedimentation rate increased ": 3.918920902624868, "Renal impairment ": 2.0960871129045366, "Renal tubular necrosis ": 3.884189364934071, "Respiratory distress ": 3.08836736286121, "Respiratory failure ": 3.229233495176351, "Sepsis ": 3.3722477685664174, "Septic shock ": 8.943578777579065, "Shock ": 4.433847037674333, "Skin lesion ": 3.640030679547249, "Staphylococcal infection ": 3.1385542133827, "Staphylococcal sepsis ": 9.81378396551248, "Stevens-Johnson syndrome ": 3.107716393098529, "Streptococcal infection ": 17.30427004045918, "Systemic candida ": 44.04506161520125, "Therapy non-responder ": 3.1886694767922874, "Thrombocytopenia ": 3.252351557203704, "Tinnitus ": 2.754651579354128, "Toxic epidermal necrolysis ": 2.5171902050598183, "Transaminases increased ": 3.188704852199632, "Transplant rejection ": 11.040073635175988, "Treatment failure ": 5.479122433260497, "Tuberculosis ": 10.360097953491495} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/670.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/670.json new file mode 100644 index 00000000000..abbe26afe0a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/670.json @@ -0,0 +1 @@ +{"Activated partial thromboplastin time prolonged ": 4.705462149717445, "Alopecia ": 2.686328531706262, "Anaemia ": 6.796587796311269, "Anal haemorrhage ": 21.132663684390533, "Atrial thrombosis ": 51.04701895647843, "Basal ganglia haemorrhage ": 30.532326583342925, "Bleeding time prolonged ": 25.243346701233516, "Blood loss anaemia ": 7.305957493458125, "Blood pressure decreased ": 2.199693311849252, "Blood urine present ": 35.401728374591656, "Cerebellar haemorrhage ": 26.738081360684, "Cerebral haemorrhage ": 18.79735478375084, "Cerebral infarction ": 6.839039001373485, "Cerebral ischaemia ": 9.805514585996791, "Cerebrovascular accident ": 4.711151968334206, "Chromaturia ": 3.146456318444303, "Colon cancer ": 3.930055850722903, "Conjunctival haemorrhage ": 10.076311803848563, "Contusion ": 2.60595841247187, "Dermatitis allergic ": 2.287985239180357, "Diverticulum intestinal haemorrhagic ": 20.619695137050822, "Duodenal ulcer ": 4.25094939236723, "Duodenal ulcer haemorrhage ": 8.003096730405808, "Ecchymosis ": 3.197845709891234, "Embolic stroke ": 25.81648769626895, "Epistaxis ": 19.17672143604868, "Eye haemorrhage ": 11.539768936071326, "Faeces discoloured ": 9.728128382810135, "Femoral neck fracture ": 6.819362956609835, "Gamma-glutamyltransferase increased ": 4.238830062019366, "Gastric haemorrhage ": 15.098828263106984, "Gastric ulcer haemorrhage ": 7.031904197190437, "Gastrointestinal haemorrhage ": 10.461450232395146, "Gingival bleeding ": 16.23723168019448, "Glomerular filtration rate decreased ": 5.076442554601303, "Haemarthrosis ": 11.77876017032896, "Haematemesis ": 4.907429352664151, "Haematochezia ": 7.792203544167881, "Haematoma ": 11.008780161986602, "Haematoma muscle ": 6.914985491947554, "Haematuria ": 22.550060663647884, "Haemoglobin decreased ": 4.208749713484409, "Haemoptysis ": 4.789159600438884, "Haemorrhage ": 7.066698727829784, "Haemorrhage intracranial ": 5.92703356924056, "Haemorrhage subcutaneous ": 9.625573609595731, "Haemorrhage urinary tract ": 7.682373977381654, "Haemorrhagic diathesis ": 6.808872444652647, "Haemorrhagic stroke ": 6.301820941326927, "Haemorrhoidal haemorrhage ": 12.95557426756336, "Hemiparesis ": 6.195765618403061, "Incorrect dose administered ": 20.41426748653862, "International normalised ratio increased ": 2.9090200625299394, "Intestinal haemorrhage ": 50.37330192525222, "Intraventricular haemorrhage ": 13.1756080849217, "Iron deficiency anaemia ": 11.553149135982896, "Ischaemic stroke ": 9.215540370567451, "Labelled drug-drug interaction medication error ": 2.7724472863580587, "Liver function test increased ": 3.2074843020773915, "Lower gastrointestinal haemorrhage ": 17.50273654570032, "Melaena ": 20.43457538005694, "Mouth haemorrhage ": 15.50421722005541, "Muscle haemorrhage ": 8.788041150014225, "Petechiae ": 3.082395822676621, "Post procedural haemorrhage ": 11.79132078421702, "Prescribed underdose ": 2.2922989361270742, "Product dose omission in error ": 5.319145280218994, "Product prescribing error ": 5.28942153508757, "Product residue present ": 12.95337182245376, "Prothrombin time prolonged ": 10.43832557775457, "Pruritus ": 3.2675712274472994, "Pulmonary embolism ": 2.609819612221366, "Purpura ": 3.008567848157621, "Rash macular ": 2.159497208530759, "Rash morbilliform ": 2.5655028597435705, "Rash pruritic ": 2.15863090811535, "Rash pustular ": 4.269600279974583, "Rectal haemorrhage ": 14.00433180472529, "Renal function test abnormal ": 9.606183613855508, "Renal haemorrhage ": 13.868630299621929, "Shock haemorrhagic ": 10.4689188616605, "Skin discolouration ": 2.1109261913051243, "Skin haemorrhage ": 25.59641644629596, "Small intestinal haemorrhage ": 22.434968652812653, "Subarachnoid haemorrhage ": 7.023625928807696, "Subcutaneous haematoma ": 7.930173410645819, "Subdural haematoma ": 9.90758528625753, "Thalamus haemorrhage ": 44.3668783129533, "Therapy cessation ": 3.9256694180937184, "Thrombosis ": 2.186727757315752, "Transient ischaemic attack ": 3.9484359472683495, "Treatment noncompliance ": 2.443507723054619, "Type IV hypersensitivity reaction ": 11.464208883399063, "Underdose ": 7.08269592862228, "Upper gastrointestinal haemorrhage ": 9.888523175927004, "Urethral haemorrhage ": 43.30575831966736, "Urinary bladder haemorrhage ": 44.1060183245777, "Vaginal haemorrhage ": 4.409942861292236, "Wound haemorrhage ": 12.236597067269292, "Wrong technique in product usage process ": 4.600057914450002} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/671.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/671.json new file mode 100644 index 00000000000..99a569dc051 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/671.json @@ -0,0 +1 @@ +{"Hypokalaemia ": 46.09987669538091} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/672.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/672.json new file mode 100644 index 00000000000..3c2bc737e9c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/672.json @@ -0,0 +1 @@ +{"Febrile neutropenia ": 23.38206119690035, "Nausea ": 2.6557462838163506, "Neutropenia ": 8.457726457204446} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/673.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/673.json new file mode 100644 index 00000000000..a355db77653 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/673.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.029979046351197, "Alopecia ": 2.278752816790884, "Anaemia ": 7.917730241563449, "Ascites ": 6.352302478703547, "Bacteraemia ": 3.005459280679409, "Biliary obstruction ": 31.98337498721818, "Blood bilirubin increased ": 2.6460735743371093, "Blood potassium decreased ": 2.0863835900605374, "Cancer pain ": 22.77968776464956, "Carbohydrate antigen 19-9 increased ": 42.57335920705888, "Carcinoembryonic antigen increased ": 42.55156315410201, "Chromaturia ": 4.276619544596277, "Colon cancer ": 7.129126715469529, "Colon cancer metastatic ": 27.655400712636325, "Colorectal cancer metastatic ": 31.77209285306245, "Constipation ": 3.0480924006547734, "Cytopenia ": 13.812080230516608, "Death ": 11.340613591005068, "Decreased appetite ": 4.048070830752336, "Dehydration ": 4.588668462598244, "Diarrhoea ": 3.075102886713893, "Disease progression ": 33.53438385997516, "Dysphonia ": 2.201331234690422, "Febrile neutropenia ": 9.407784526088236, "Feeding disorder ": 2.7428534297056557, "Full blood count abnormal ": 6.023692379471247, "Gastrointestinal toxicity ": 8.75236664587835, "General physical health deterioration ": 2.427989080984312, "Haematotoxicity ": 7.130697356303676, "Haemoglobin decreased ": 3.645895770628058, "Hepatic failure ": 3.0403359611977687, "Hospitalisation ": 7.42618719347173, "Hydronephrosis ": 5.704149244143079, "Hyperbilirubinaemia ": 2.556312633099909, "Hypophagia ": 2.41741965171428, "Inappropriate schedule of product administration ": 8.573613017843925, "Intentional product use issue ": 6.709232006755912, "Intercepted product prescribing error ": 50.29835026126475, "Intestinal obstruction ": 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17.46911214507023, "Generalised tonic-clonic seizure ": 14.50084368750199, "Hypocalcaemia ": 28.709133522073564, "Hypoparathyroidism ": 532.6009034077952, "Hypotension ": 2.967662823140212, "Mental disorder ": 9.37636320254358, "Muscle twitching ": 12.193786743794403, "Myoclonus ": 32.00133395568836, "Neuroleptic malignant syndrome ": 22.794503539131547, "Overdose ": 6.888201236158349, "Parkinsonism ": 34.10754488140372, "Poisoning ": 64.84474681924394, "Poisoning deliberate ": 59.6502768504546, "Product use in unapproved indication ": 2.804162695976544, "Pulmonary embolism ": 2.5113314247839105, "Sedation ": 14.53558252909778, "Seizure ": 2.501151490031622, "Somnolence ": 3.003379631822912, "Suicide attempt ": 5.288660770896732, "Tardive dyskinesia ": 54.984589144793546, "Toxicity to various agents ": 6.251686584021923, "Treatment failure ": 13.916666631202588, "Weight increased ": 2.1533362830076164} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/677.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/677.json new file mode 100644 index 00000000000..3100a0e40eb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/677.json @@ -0,0 +1 @@ +{"Eye irritation ": 27.923730388082124, "Eye pain ": 17.82701144203305, "Vision blurred ": 4.530590928327984, "Visual acuity reduced ": 38.290648912713706, "Visual impairment ": 5.673552456338943, "Vitreous floaters ": 50.7839591065242} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/678.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/678.json new file mode 100644 index 00000000000..fbc2706b960 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/678.json @@ -0,0 +1 @@ +{"Drug interaction ": 42.273599806397776, "Drug level decreased ": 575.3483451786454} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/679.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/679.json new file mode 100644 index 00000000000..a919988dece --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/679.json @@ -0,0 +1 @@ +{"Corneal opacity ": 533.1505615899403, "Fall ": 5.402952654642398, "Intraocular pressure increased ": 159.09026808163892} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/68.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/68.json new file mode 100644 index 00000000000..c1631bf40f1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/68.json @@ -0,0 +1 @@ +{"Abdominal pain ": 3.3437141919860025, "Adjustment disorder with depressed mood ": 32.407784685791746, "Adverse drug reaction ": 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"Treatment noncompliance ": 2.521055693229441, "Tuberculoma of central nervous system ": 42.360349954131486, "Tuberculosis ": 30.57288789121698, "Uraemic encephalopathy ": 154.98763315654847, "Vaginal discharge ": 87.03466527243312, "Vaginal flatulence ": 206.98563694845055, "Ventricular extrasystoles ": 5.159829738245159, "Weight decreased ": 5.490725383114952, "White blood cell count increased ": 4.48143174191488} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/680.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/680.json new file mode 100644 index 00000000000..70bb32548df --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/680.json @@ -0,0 +1 @@ +{"Dizziness ": 2.903327044432503, "Hypersensitivity ": 10.491812645552178} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/681.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/681.json new file mode 100644 index 00000000000..36145bfc0f5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/681.json @@ -0,0 +1 @@ +{"Adverse drug reaction ": 15.624488438250165, "Alanine aminotransferase increased ": 4.91060464575573, "Aspartate aminotransferase increased ": 5.613064780348587, "Cholestasis ": 18.831227719531736, "Diarrhoea ": 7.907430577262925, "Disease progression ": 128.2050592903027, "Hepatic cytolysis ": 58.380440353621815, "Hepatic enzyme increased ": 7.465820312607308, "Hepatotoxicity ": 50.388295503148655, "Lung adenocarcinoma ": 247.78417504984668, "Non-small cell lung cancer ": 262.62199792081105, "Off label use ": 3.1660013465774504} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/682.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/682.json new file mode 100644 index 00000000000..7407a868556 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/682.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.7249268134251623, "Abdominal pain upper ": 2.3201922779563326, "Acute kidney injury ": 2.3251902215106406, "Alopecia ": 2.1662788086983205, "Blood creatinine increased ": 11.126481027574018, "Blood pressure increased ": 2.42346314653226, "Dehydration ": 3.1530063542706386, "Glomerular filtration rate decreased ": 54.10652661597313, "Hyperkalaemia ": 3.2292311509411893, "Hypertension ": 11.374951146910236, "Joint swelling ": 2.491234741061107, "Lupus nephritis ": 155.4193937872188, "Memory impairment ": 2.151472970190159, "Oedema ": 3.124616948541081, "Product dose omission issue ": 5.418544172281393, "Proteinuria ": 45.94678797603984, "Renal impairment ": 4.386016831111509, "Systemic lupus erythematosus ": 24.51061087989994, "Therapy interrupted ": 60.49324747626236, "Tremor ": 2.3838933776968827, "Urinary tract infection ": 3.1798811876177697, "Urine protein/creatinine ratio increased ": 2514.128171906478, "Weight decreased ": 2.04772593949959} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/683.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/683.json new file mode 100644 index 00000000000..98945e4019f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/683.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 15.157694377695112, "Affect lability ": 25.37238668375416, "Aggression ": 13.398758145226614, "Agitation ": 6.932777359124982, "Akathisia ": 38.58075478871739, "Anosognosia ": 275.6954898661859, "Completed suicide ": 25.219381301105365, "Condition aggravated ": 3.2758868914843324, "Delusion ": 35.31515533057852, "Depressed mood ": 5.137454208885906, "Drug ineffective for unapproved indication ": 40.96367447735837, "Extrapyramidal disorder ": 11.732415876037631, "Hallucination, auditory ": 35.75094149436588, "Hostility ": 134.50611419118653, "Hyperprolactinaemia ": 169.6362941259309, "Intentional product misuse ": 2.365366297291258, "Irritability ": 5.09276508583079, "Mania ": 26.33287787536992, "Medication error ": 14.313870110906905, "Myocarditis ": 5.952689749045105, "Neuroleptic malignant syndrome ": 20.48484485657965, "Off label use ": 4.156123352044497, "Overdose ": 3.9029597959734046, "Paradoxical drug reaction ": 98.99268137396714, "Persecutory delusion ": 86.42905429623825, "Persistent genital arousal disorder ": 4464.526009175805, "Psychotic disorder ": 8.879112032409159, "Psychotic symptom ": 221.79228294144903, "Schizophrenia ": 57.35541437371493, "Sedation ": 18.28555559926985, "Serotonin syndrome ": 34.98809190421349, "Sleep disorder ": 2.4417419319407294, "Suicidal ideation ": 7.637357998055891, "Tardive dyskinesia ": 32.6024874450853, "Therapeutic response decreased ": 7.96995221824886, "Toxicity to various agents ": 8.60669550186828, "Treatment noncompliance ": 13.187563734024057, "Weight increased ": 2.1472522977042146, "Withdrawal syndrome ": 16.10687412437745} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/684.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/684.json new file mode 100644 index 00000000000..6ca22b477c0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/684.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.4284638987535034, "Alopecia ": 3.0420841118096336, "Ascites ": 5.0770647999392216, "Carcinoid crisis ": 729.9988052503513, "Carcinoid syndrome ": 372.307967345474, "Disease progression ": 11.408197248332543, "Eating disorder ": 6.5331749117395095, "Faeces soft ": 27.946625081114437, "Flushing ": 8.427859626246216, "Gastroenteropancreatic neuroendocrine tumour disease ": 1591.4611163225388, "General physical health deterioration ": 7.790425950770851, 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"Weight decreased ": 2.060968086459456} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/685.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/685.json new file mode 100644 index 00000000000..2b77aee8f25 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/685.json @@ -0,0 +1 @@ +{"Alopecia ": 3.763309598438707, "Anaemia ": 5.2412496160105055, "Blood pressure systolic increased ": 19.2508836720835, "Body temperature decreased ": 29.588294205029012, "Carcinoid crisis ": 1264.3536851062606, "Constipation ": 2.0435113117380914, "Disease progression ": 2.279656577696442, "Eating disorder ": 24.130595487623506, "Faeces soft ": 61.352075302252274, "Haematotoxicity ": 53.23100045612008, "Illness ": 2.773754497421828, "Injection site mass ": 24.14235755997068, "Leukopenia ": 7.012303433342856, "Malignant neoplasm progression ": 7.052373895510567, "Myelodysplastic syndrome 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new file mode 100644 index 00000000000..f35554c3d43 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/687.json @@ -0,0 +1 @@ +{"Abdominal distension ": 63.366491315461104, "Abdominal pain ": 13.562397155142616, "Abdominal pain lower ": 41.22377280101578, "Ascites ": 23.48742004773497, "Chest discomfort ": 6.0168872954927695, "Dyspnoea ": 2.584030096245786, "Nausea ": 2.0954448636457466, "Ovarian hyperstimulation syndrome ": 1783.289084149633, "Vomiting ": 2.964469747017076, "Waist circumference increased ": 1068.125355537261} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/688.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/688.json new file mode 100644 index 00000000000..25986b2c839 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/688.json @@ -0,0 +1 @@ +{"Blindness ": 29.528157804574704, "Intraocular pressure increased ": 429.7422670112431, "Photophobia ": 33.10168806744936, "Retinal degeneration ": 8002.012273288915, "Retinal deposits ": 9965.152892245856, "Retinal detachment ": 305.5062079943043, "Retinal tear ": 709.9379170442716, "Vision blurred ": 8.636445954402651, "Visual impairment ": 15.390855893424083} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/689.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/689.json new file mode 100644 index 00000000000..05ec263a419 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/689.json @@ -0,0 +1 @@ +{"Acute leukaemia ": 15.207844750106952, "Acute myeloid leukaemia ": 25.191849407431505, "Adverse drug reaction ": 2.217153309336953, "Anaemia ": 34.21014438528105, "Ascites ": 3.7112777515745257, "Blood creatinine increased ": 2.732543476246841, "Blood test abnormal ": 2.445219008354557, "Carbohydrate antigen 125 increased 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increased ": 12.811893746207485, "Pulmonary toxicity ": 2.8325182373035886, "Recurrent cancer ": 34.705306466483904, "Red blood cell count decreased ": 5.516407801376233, "Renal impairment ": 2.874502390787614, "Stomatitis ": 2.2713300490759063, "Taste disorder ": 6.621062715260355, "Thrombocytopenia ": 4.646955866063744, "Tumour marker increased ": 48.00345852090853, "White blood cell count decreased ": 3.803987908531559} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/69.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/69.json new file mode 100644 index 00000000000..e8080df8023 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/69.json @@ -0,0 +1 @@ +{"Ventricular tachycardia ": 52.8856459910641} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/690.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/690.json new file mode 100644 index 00000000000..832987219b9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/690.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 2.304746112151262, "Accident at work ": 7.896435367570602, "Aggression ": 2.502536961681152, "Agitation ": 2.1496008369226582, "Altered state of consciousness ": 3.5281681128856146, "Amnesia ": 3.2790992933892125, "Aneurysm ": 2.050321555741438, "Anger ": 2.8832334185879467, "Ankle fracture ": 2.265033883015292, "Ataxia ": 3.2096131492473, "Back disorder ": 10.10560767904088, "Back injury ": 3.898304783899627, "Balance disorder ": 2.380580131187978, "Bedridden ": 2.2220456618092865, "Behaviour disorder ": 2.403006636835625, "Bipolar disorder ": 2.1188013758066866, "Bladder disorder ": 2.59103728976664, "Blood disorder ": 2.31766545575503, "Blood pressure abnormal ": 3.5289564209797137, "Blood sodium decreased ": 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10.759858698931872, "Fall ": 3.8967362395573866, "Fear ": 2.716167522723849, "Feeling abnormal ": 3.7713802151917264, "Feeling drunk ": 6.431967538926984, "Fibromyalgia ": 6.984072770589046, "Fluid retention ": 2.0908405856265952, "Foot fracture ": 2.2617666870674014, "Gait disturbance ": 2.994555795534975, "Gait inability ": 2.677998695615264, "Gastrointestinal sounds abnormal ": 2.822372060384305, "Generalised anxiety disorder ": 5.57112066664281, "Hallucination ": 3.016653610318668, "Hallucination, visual ": 3.1899930063484985, "Hallucinations, mixed ": 2.994477298127325, "Head injury ": 2.988036728157918, "Hepatic cytolysis ": 3.411137044179161, "Hernia ": 5.406900300801098, "Hyperlipidaemia ": 2.6633295416151253, "Hypersomnia ": 2.224067639801236, "Hyporeflexia ": 2.718293052472552, "Illness ": 2.3341780381653754, "Impaired driving ability ": 9.84199815922839, "Increased appetite ": 2.715201198991129, "Infective exacerbation of chronic obstructive airways disease ": 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"Psychomotor hyperactivity ": 2.1981642587290597, "Pulmonary thrombosis ": 3.141320055436205, "Pulmonary vascular resistance abnormality ": 189.433727430944, "Raynaud's phenomenon ": 2.0596882465307185, "Respiratory depression ": 3.5042459945546325, "Respiratory rate decreased ": 9.05834803322403, "Rhabdomyolysis ": 2.883749696193728, "Road traffic accident ": 6.22930393514226, "Sciatica ": 2.7674731205533214, "Sedation ": 3.2081484307212422, "Sensory loss ": 2.7508140847018545, "Sinus disorder ": 2.117530144028384, "Sjogren's syndrome ": 2.8975300755347253, "Sleep apnoea syndrome ": 3.2712674102035946, "Small intestinal obstruction ": 2.5140323324628544, "Social avoidant behaviour ": 2.2284792188845395, "Somnambulism ": 3.3853701653873003, "Somnolence ": 4.276325181778902, "Sopor ": 5.673833173102482, "Speech disorder ": 3.746990753168942, "Spinal column injury ": 6.659320175476379, "Spinal disorder ": 12.688716992478335, "Spinal fracture ": 2.605942913916511, "Spinal fusion surgery ": 4.60852882996694, "Spinal operation ": 3.125322458117241, "Spinal stenosis ": 3.167852980412283, "Substance use disorder ": 3.1043065071430163, "Sudden onset of sleep ": 5.416030893573151, "Suicidal ideation ": 2.792754734403592, "Suicide attempt ": 3.544014270839005, "Thinking abnormal ": 6.12180895640913, "Thyroid function test abnormal ": 5.148057677538167, "Toxic encephalopathy ": 2.218905308518178, "Type 2 diabetes mellitus ": 2.123096234314381, "Underdose ": 2.644347220793812, "Upper limb fracture ": 2.950091569427575, "Urinary incontinence ": 2.4252676051722104, "Urinary retention ": 3.242682768891989, "Urine abnormality ": 3.162055417140008, "Vision blurred ": 2.458921802057494, "Vitamin B12 deficiency ": 3.3800254127095326, "Vitamin D decreased ": 3.0119838845911846, "Weight increased ": 5.088366398311565, "Weight loss poor ": 3.929569603194068, "Withdrawal syndrome ": 7.04597262515944, "Wrong patient received product ": 4.618120617291731} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/691.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/691.json new file mode 100644 index 00000000000..c02db439bc2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/691.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 44.281390988049765, "Asthenia ": 2.088182812765148, "Decreased appetite ": 2.039283141278161, "Disturbance in attention ": 5.628209468934589, "Gamma-glutamyltransferase increased ": 12.242512024210331, "General physical health deterioration ": 4.466366245119725, "Hepatic enzyme increased ": 5.57478748706496, "Hypokalaemia ": 3.327568512886822, "Hypothyroidism ": 7.792186168294314, "Malignant neoplasm progression ": 7.1671120220053, "Memory impairment ": 3.0518598258782337, "Off label use ": 2.104002939154881, "Somnolence ": 3.620144475900979, "Vertigo ": 2.235873749672955, "Vomiting ": 2.237848237231778, "Weight decreased ": 3.508755933564427} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/692.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/692.json new file mode 100644 index 00000000000..76ba06a5e62 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/692.json @@ -0,0 +1 @@ +{"Blood glucose abnormal ": 35.67015555704494, "Blood glucose decreased ": 12.020110699608816, "Blood glucose fluctuation ": 29.7734680108193, "Blood glucose increased ": 29.78010194026098, "Drug ineffective ": 2.26426645160208, "Expired product administered ": 15.131490389792624, "Glycosylated haemoglobin increased ": 23.480798525429787, "Hyperglycaemia ": 16.941635120085436, "Hypoglycaemia ": 14.840986533815109, "Incorrect dose administered ": 22.27189997292105, "Infusion site erythema ": 378.7068424793442, "Infusion site haemorrhage ": 262.73610743808274, "Infusion site induration ": 1638.7925262499334, "Infusion site inflammation ": 835.8845780395651, "Infusion site pain ": 1479.5861239778103, "Infusion site pruritus ": 468.8194607652781, "Infusion site swelling ": 121.98537586232004, "Injection site bruising ": 27.97931356491879, "Injection site erythema ": 13.669935236693926, "Injection site induration ": 17.396373382693593, "Injection site mass ": 43.04204303733281, "Injection site pain ": 15.211592454047496, "Injection site pruritus ": 13.984652241906804, "Injection site reaction ": 6.199753713454663, "Wrong technique in product usage process ": 9.733286507377985} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/693.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/693.json new file mode 100644 index 00000000000..24d2d18496c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/693.json @@ -0,0 +1 @@ +{"Agranulocytosis ": 5.171829540164675, "Anaemia ": 2.1898920665727366, "Autoimmune haemolytic anaemia ": 57.82679205829911, "Bone marrow failure ": 29.362793696680864, "Cytomegalovirus infection ": 73.15110159435204, "Cytomegalovirus infection reactivation ": 77.28949380753357, "Guillain-Barre syndrome ": 13.43619225958807, "Hypotension ": 2.623383310914643, "Infection ": 2.892377519863435, "Leukopenia ": 4.59394493019408, "Lymphopenia ": 28.46581378946015, "Malignant neoplasm progression ": 2.2952875163023787, "Neutropenia ": 5.711085702770604, "Pancytopenia ": 12.059216786587651, "Pleural effusion ": 5.514504790889189, "Pneumonia ": 2.297403703866795, "Progressive multifocal leukoencephalopathy ": 67.38752508970668, "Sepsis ": 5.425476585432718, "Thrombocytopenia ": 5.158187948141624} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/694.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/694.json new file mode 100644 index 00000000000..521112148cb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/694.json @@ -0,0 +1 @@ +{"Acute hepatitis B ": 79.25371624289451, "Acute myeloid leukaemia ": 4.141104142459735, "Acute respiratory distress syndrome ": 3.929758691381151, "Agranulocytosis ": 21.35592202430412, "Anaemia ": 2.2912328545258185, "B-cell lymphoma recurrent ": 87.60224945377034, "Bicytopenia ": 13.29593638447238, "Bone marrow failure ": 12.71043646351251, "Cardiac failure ": 2.4231624543484327, "Cardiomyopathy ": 4.673806257893796, "Cytomegalovirus infection ": 3.8908767942613873, "Cytopenia ": 12.448662665677974, "Dermatitis exfoliative generalised ": 5.151369433240756, "Diffuse large B-cell lymphoma recurrent ": 49.93232641021019, "Disease progression ": 4.188394116159946, "Disease recurrence ": 2.5983683547370484, "Ejection fraction decreased ": 3.183457138654644, "Febrile bone marrow aplasia ": 57.595154942346966, "Febrile neutropenia ": 20.043343567149268, "Full blood count decreased ": 6.508644197216642, "Granulocyte count decreased ": 37.55484819352679, "Granulocytopenia ": 12.533068739759791, "Haemoglobin decreased ": 2.2126612255206, "Hepatic cytolysis ": 3.685245391831023, "Hepatic failure ": 2.262710952945633, "Hepatitis B ": 12.968281761654218, "Hepatitis B reactivation ": 60.83092471733034, "Hyperpyrexia ": 2.147906795748211, "Hypogammaglobulinaemia ": 15.9027082667804, "Infection ": 3.3525329448264727, "Infusion related reaction ": 3.663189675439032, "Intentional product use issue ": 4.341645693306297, "Interstitial lung disease ": 6.6573274215883895, "Leukopenia ": 10.52508503688411, "Lung disorder ": 3.182178222229484, "Lung infiltration ": 4.979017783483184, "Lymphoma ": 4.692779402081943, "Lymphopenia ": 8.472184485878547, "Mucosal inflammation ": 4.347918998995172, "Multiple organ dysfunction syndrome ": 2.6259913780759443, "Myelodysplastic syndrome ": 5.493830037244657, "Myelosuppression ": 48.20506914867611, "Neurotoxicity ": 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/695.json new file mode 100644 index 00000000000..67ab6a534f4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/695.json @@ -0,0 +1 @@ +{"Bone deformity ": 25827.71185109847, "Graft complication ": 69022.96824143936, "Transplant failure ": 2971.3211525250745} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/696.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/696.json new file mode 100644 index 00000000000..8881a4046c8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/696.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.328803829800042, "Ascites ": 5.7853181420963065, "Blood pressure decreased ": 4.974155018442401, "Condition aggravated ": 2.2083024410575582, "Disease progression ": 4.7011009169207, "Dyspnoea ": 2.8255215718145386, "Epistaxis ": 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19.20432157929326, "Syncope ": 2.602529832754711, "Vascular device infection ": 70.31561265457778} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/697.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/697.json new file mode 100644 index 00000000000..6bf8617980a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/697.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 6.722012458829095, "Alanine aminotransferase increased ": 3.978084233443691, "Altered state of consciousness ": 5.262091304159024, "Anaphylactic reaction ": 2.537626793672219, "Arrhythmia ": 2.8696161635906186, "Aspartate aminotransferase increased ": 8.81175030362971, "Blood alkaline phosphatase increased ": 7.087680750848746, "Blood bilirubin increased ": 6.658724086828021, "Blood lactate dehydrogenase increased ": 10.213913209647584, "Blood lactic acid increased ": 36.55478555195216, "Bradycardia foetal ": 120.68706507158598, "Brain oedema ": 20.95745080810684, "Cardiomyopathy ": 16.42023319680405, "Disease progression ": 3.117213923467475, "Disseminated intravascular coagulation ": 8.881459736169768, "Drug ineffective ": 2.689694827373577, "Foetal exposure during pregnancy ": 3.0986054003782653, "Gamma-glutamyltransferase increased ": 5.852570473464167, "Gastrointestinal disorder ": 3.216957661056536, "Hepatic function abnormal ": 5.592244400988305, "Hypokalaemia ": 3.987309188677058, "Hyponatraemia ": 4.607503304319176, "Hypotension ": 2.2072612863967334, "Intraocular pressure increased ": 23.955267672282307, "Low birth weight baby ": 14.254371169103957, "Metabolic acidosis ": 7.857124829315548, "Myelosuppression ": 22.981492639911885, "Nephropathy toxic ": 19.14072067562964, "Palmar erythema ": 133.11433221108734, "Platelet count decreased ": 2.359311898350774, "Premature baby ": 8.642685573808313, "Productive cough ": 6.105726415386842, "Respiratory failure ": 3.86729493061424, "Rhabdomyolysis ": 3.344413496146685, "Toxic epidermal necrolysis ": 18.609102870062333, "White blood cell count decreased ": 2.602616067140603, "Withdrawal hypertension ": 843.2177030145225} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/698.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/698.json new file mode 100644 index 00000000000..94d15d3a01b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/698.json @@ -0,0 +1 @@ +{"Back pain ": 4.099885419004326, "Pneumonia ": 4.133408481761401} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/699.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/699.json new file mode 100644 index 00000000000..afa7f1d2986 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/699.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 2.4906783256451277, "Acne ": 2.635085311351826, "Alanine aminotransferase increased ": 5.8258627480972045, "Alopecia ": 6.562565434225435, "Aspartate aminotransferase increased ": 5.061810481386424, "Breast cancer ": 2.1640453128530317, "COVID-19 ": 2.2894308681030706, "Central nervous system lesion ": 10.44359074066859, "Diplopia ": 2.2777941921831943, "Drug-induced liver injury ": 2.164991269747034, "Expanded disability status scale score increased ": 723.4151365460845, "Gamma-glutamyltransferase increased ": 4.950399284891678, "Herpes simplex ": 13.868369911307, "Herpes zoster ": 6.673886345570021, "Leukopenia ": 2.39433463064217, "Live birth ": 5.838032820397292, "Lymphocyte count decreased ": 326.85481159665795, "Lymphopenia ": 245.25829444617733, "Maternal exposure before pregnancy ": 35.14603627754939, "Maternal exposure timing unspecified ": 18.5411422160925, "Multiple sclerosis ": 77.61281487196355, "Multiple sclerosis relapse ": 175.07429808851833, "Nasopharyngitis ": 4.2182235135714405, "Neutrophil count decreased ": 2.499546350397545, "Optic neuritis ": 12.2719335947408, "Oral herpes ": 18.53042827262662, "Product administration error ": 2.096463515476069, "Sensory disturbance ": 2.6691916818738584, "Upper respiratory tract infection ": 4.740294137978795, "Urinary tract infection ": 4.977302044010598, "White blood cell count decreased ": 5.205688873491689} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/7.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/7.json new file mode 100644 index 00000000000..3f4f5e0f797 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/7.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 3.675425746243086, "Abnormal weight gain ": 3.6563687570220855, "Accident ": 3.7244892433680135, "Accommodation disorder ": 4.318415133287264, "Adverse drug reaction ": 3.5350140969338937, "Affective disorder ": 3.127977635794941, "Aggression ": 7.282472135830056, "Agitation ": 3.349745374987725, "Akathisia ": 58.88661279333641, "Alcoholism ": 7.529271427556875, "Allergy to animal ": 7.597548083916496, "Amphetamines positive ": 19.97850996290246, "Analgesic drug level above therapeutic ": 269.13885103715563, "Anger ": 4.138060861153133, "Anorgasmia ": 6.923220431133673, "Anosognosia ": 811.7473321207051, "Antidepressant drug level above therapeutic ": 66.62300005378003, "Antipsychotic drug level below therapeutic ": 237.50794988698203, "Antipsychotic drug level increased ": 3.860186491583365, "Anxiety ": 2.3224671878730354, "Anxiety disorder ": 9.072679408953784, "Apathy ": 5.275930599594846, "Atrophy ": 24.360455772253943, "Attention deficit hyperactivity disorder ": 2.071235623122248, "Behaviour disorder ": 2.1206745283380566, "Binge eating ": 14.41324561334187, "Bipolar I disorder ": 5.5813945059498815, "Bipolar disorder ": 15.764130373977425, "Blood bicarbonate decreased ": 9.1049112387039, "Blood creatine phosphokinase increased ": 3.0012784991716672, "Blood creatinine decreased ": 4.443707301634298, "Blood glucose increased ": 2.7669754743843997, "Blood prolactin abnormal ": 1364.0484434078382, "Blood prolactin increased ": 11.718153295184276, "Blood triglycerides increased ": 2.604114978135373, "Body temperature abnormal ": 2.296994289177632, "Body temperature decreased ": 2.4353530300096207, "Borderline personality disorder ": 14.74527624607922, "Botulism ": 64.09943774249, "Bradykinesia ": 2.265202411747282, "Bradyphrenia ": 2.257940766582806, "Breech presentation ": 79.98185158090354, "Bruxism ": 6.649561515372604, "Bundle branch block right ": 2.438039539429133, "Caesarean section ": 9.982037308704705, "Calcium ionised decreased ": 83.35343939989477, "Catatonia ": 3.995800109314074, "Cleft lip and palate ": 5.813513897146685, "Cogwheel rigidity ": 4.788458877734608, "Coma ": 2.072918949795687, "Communication disorder ": 2.0631288399651333, "Compulsive sexual behaviour ": 66.12822527511668, "Compulsive shopping ": 56.928017852095344, "Concussion ": 3.610408947119077, "Contrast media allergy ": 7.9707485302043395, "Decreased interest ": 3.9465863074468337, "Delusion ": 8.467168362173059, "Delusional disorder, persecutory type ": 152.4840657694575, "Depressed level of consciousness ": 2.198927377811663, "Depression ": 2.8090712789857384, "Depressive symptom ": 3.2467226465185983, "Derealisation ": 2.789014043641911, "Diabetes mellitus ": 7.160985152346186, "Dialysis ": 4.603195056511371, "Disability ": 2.2401280234567853, "Disease recurrence ": 2.3366401785817024, "Disinhibition ": 138.02771173803418, "Disturbance in social behaviour ": 203.7405551609328, "Drooling ": 3.2572314748298234, "Drug effective for unapproved indication ": 4.502342035523024, "Drug interaction ": 2.6554956201486, "Drug withdrawal syndrome neonatal ": 5.645905256300755, "Dry eye ": 2.771828459275965, "Dust allergy ": 4.110600996032065, "Dyskinesia ": 15.692865848775693, "Dyskinesia neonatal ": 78.76470344929817, "Dyslipidaemia ": 40.78053740906228, "Dystonia ": 39.17464153176729, "Eating disorder ": 3.2096263907320277, "Electrocardiogram QT prolonged ": 3.516840318054676, "Emotional disorder ": 4.240201602179114, "Emotional poverty ": 5.3245266242829, "Enuresis ": 3.2189303916592835, "Euphoric mood ": 43.05277876806922, "Exposure via breast milk ": 3.311328262070821, "Extrapyramidal disorder ": 16.605309826226417, "Fear ": 2.457177193388966, "Feeling guilty ": 10.543807530742638, "Feeling of despair ": 4.05434602716916, "Flank pain ": 5.12408247548939, "Flat affect ": 5.291493372011236, "Foetal distress syndrome ": 13.232820404473838, "Foetal exposure during pregnancy ": 3.3994615804209625, "Foetal growth restriction ": 3.2586469485929896, "Foetal heart rate decreased ": 8.86688467539991, "Food craving ": 4.168067091307857, "Galactorrhoea ": 7.464655617758531, "Gambling disorder ": 26.91008209519553, "Gestational diabetes ": 14.376328160011749, "Gestational hypertension ": 24.29753753268703, "Glucose tolerance impaired ": 4.60899047970853, "Gynaecomastia ": 5.557026528778535, "Haemangioma ": 3.315247620901477, "Haematocrit decreased ": 2.4875027140086776, "Hallucination, auditory ": 15.51193521210926, "Hallucination, visual ": 2.330773930251467, "Hallucinations, mixed ": 43.53443381646376, "Homicidal ideation ": 4.973334938760129, "Humidity intolerance ": 86.95783755460094, "Hunger ": 2.830918110374303, "Hyperphagia ": 5.832356104265439, "Hyperprolactinaemia ": 10.5796509433522, "Hypersomnia ": 2.049972688583395, "Hypertension ": 2.605814546966234, "Hyperthermia ": 2.4099568667395035, "Hypoaesthesia eye ": 197.26203943944765, "Hypoglycaemia neonatal ": 7.045818457262448, "Hypomania ": 3.697783357189534, "Hypothermia ": 2.727639078176121, "Hypothyroidism ": 4.175130506125828, "Hypoxic-ischaemic encephalopathy ": 10.157120966813215, "Impatience ": 22.87384207231726, "Impulse-control disorder ": 16.75123112795543, "Impulsive behaviour ": 12.273953157695423, "Inability to afford medication ": 8.930202475636476, "Inappropriate schedule of product administration ": 2.3380392031523503, "Increased appetite ": 33.11811341749913, "Infarction ": 6.195724303536501, "Infertility ": 10.184574056984806, "Insomnia ": 2.223457826243262, "Insurance issue ": 35.8062619548615, "Intentional overdose ": 3.772529946033434, "Intentional self-injury ": 5.965053291818346, "International normalised ratio abnormal ": 6.730385310330717, "Intestinal obstruction ": 2.3371158770762417, "Intrusive thoughts ": 14.927222602381876, "Irritability ": 6.647982920703926, "Jaundice neonatal ": 16.503846071316257, "Joint effusion ": 5.74953079535982, "Large for dates baby ": 12.734298551573785, "Left ventricular dysfunction ": 5.33035179267404, "Leukaemia ": 32.42495844778806, "Leukopenia ": 4.383188797993573, "Libido decreased ": 2.9038114404415607, "Libido increased ": 4.705213970829912, "Ligament sprain ": 3.3090728013630875, "Live birth ": 7.838143885716013, "Loss of employment ": 4.889162168256731, "Loss of libido ": 4.214250623596751, "Major depression ": 4.748040716114136, "Mania ": 11.54587732904396, "Mastication disorder ": 5.240389297729403, "Maternal exposure during pregnancy ": 3.874135695304656, "Memory impairment ": 3.134575846333691, "Menopause ": 4.8554980416227576, "Mental disorder ": 4.886333254395177, "Mental impairment ": 3.039389038283853, "Metabolic disorder ": 83.15517160287843, "Metabolic syndrome ": 29.55024842669443, "Milk allergy ": 10.856886804758512, "Mixed liver injury ": 3.634086902597341, "Mood altered ": 2.954844296794644, "Muscle contracture ": 3.1551888221935767, "Muscle disorder ": 2.947294244670653, "Muscle rigidity ": 4.703394246839595, "Mutism ": 6.850632482819692, "Mycotic allergy ": 4.907725424495013, "Mydriasis ": 2.359942946443465, "Myofascial pain syndrome ": 47.29777488164353, "Negative thoughts ": 3.763533281688927, "Neonatal respiratory distress ": 18.546648288026617, "Neonatal respiratory distress syndrome ": 4.270081839263074, "Neuroleptic malignant syndrome ": 15.226735240454625, "Normal newborn ": 6.236304935827589, "Obesity ": 33.18425407466267, "Obsessive-compulsive disorder ": 73.19126478121633, "Oculogyric crisis ": 28.628464108084536, "Ophthalmoplegia ": 3.656175965973194, "Oropharyngeal discomfort ": 7.23488701428434, "Orthostatic hypertension ": 111.36976972814588, "Overdose ": 2.333792449099305, "Panic disorder ": 2.140331538996817, "Panic reaction ": 8.749059074626432, "Paranoia ": 3.6071599831000976, "Parkinson's disease ": 2.606553734423559, "Parkinsonism ": 18.565155826930127, "Patient elopement ": 19.17713849898944, "Perinatal depression ": 30.666410785618048, "Persecutory delusion ": 4.397965829307505, "Persistent depressive disorder ": 11.225204172208752, "Personal relationship issue ": 12.03718113707504, "Personality change ": 36.76274515306304, "Personality change due to a general medical condition ": 127.7461421799497, "Personality disorder ": 8.349169416418253, "Piloerection ": 6.719464659881618, "Pleurothotonus ": 11.008924038585253, "Pneumonia aspiration ": 2.252954259495824, "Poisoning deliberate ": 2.921610012116054, "Polyuria ": 3.5458609860547385, "Poor feeding infant ": 5.574032999273601, "Post-traumatic stress disorder ": 2.3970855859714644, "Posture abnormal ": 10.40767395781147, "Potentiating drug interaction ": 2.367437073774622, "Pregnancy ": 4.791669390296495, "Premature baby ": 6.548518918479444, "Premature delivery ": 6.642401606456948, "Premature labour ": 3.4091642539582856, "Prescribed overdose ": 14.971827050956584, "Prescribed underdose ": 6.380167763945899, "Product dose omission issue ": 2.2117073725754888, "Product use in unapproved indication ": 5.033011443581888, "Psychiatric decompensation ": 9.615305348013736, "Psychiatric symptom ": 5.616737573158261, "Psychomotor hyperactivity ": 4.158956068754716, "Psychomotor retardation ": 4.697350117455549, "Psychomotor skills impaired ": 4.582932270202171, "Psychotic disorder ": 17.89131769235133, "Psychotic symptom ": 32.83947208469103, "Refusal of treatment by patient ": 10.889222495940286, "Restless legs syndrome ": 2.9236414487355464, "Restlessness ": 4.191271032900143, "Rhabdomyolysis ": 2.330241846867506, "Rhesus incompatibility ": 2170.426636709448, "Rubber sensitivity ": 10.028048987094346, "Salivary hypersecretion ": 4.663403950523844, "Schizoaffective disorder ": 86.50235992561116, "Schizophrenia ": 47.54435432793934, "Schizophreniform disorder ": 25.378071839638825, "Screaming ": 2.157681560492145, "Sedation ": 25.499697330069573, "Self-destructive behaviour ": 6.792979480540944, "Self-injurious ideation ": 2.710593751162179, "Sepsis neonatal ": 18.34742069640324, "Serotonin syndrome ": 3.057834389864757, "Sexual dysfunction ": 53.201182762049015, "Social anxiety disorder ": 8.345624915886523, "Social avoidant behaviour ": 15.426590235610645, "Social fear ": 47.904674034745575, "Somatic symptom disorder ": 18.37543113785225, "Sopor ": 4.072121364993928, "Staphylococcal infection ": 7.904162504974314, "Status epilepticus ": 2.3632228596190266, "Stubbornness ": 111.7568272976294, "Stupor ": 2.7600823538025265, "Substance abuse ": 3.5263130986333024, "Substance use ": 287.73242157640954, "Substance-induced psychotic disorder ": 21.314506958951185, "Sudden cardiac death ": 6.061196339269173, "Suicidal behaviour ": 2.457773213672281, "Suicidal ideation ": 4.838090286753683, "Suicide attempt ": 15.295255075273252, "Symptom recurrence ": 14.386164822575331, "Tachyphrenia ": 5.41640874309355, "Tardive dyskinesia ": 26.24833478342308, "Tension ": 2.224285691146488, "Therapeutic product effect incomplete ": 6.062170272622497, "Therapeutic product effect variable ": 163.82787596914008, "Therapy cessation ": 4.841348670567941, "Therapy change ": 3.113166326444243, "Therapy non-responder ": 2.293477831493164, "Thermal burn ": 34.178912544689204, "Thinking abnormal ": 6.098253062154013, "Throat tightness ": 3.339873002426077, "Tic ": 6.4360146466369, "Toxicity to various agents ": 4.5175373092797, "Transfusion ": 3.281012722375777, "Transient tachypnoea of the newborn ": 47.03481217766212, "Treatment noncompliance ": 7.779769719925113, "Tremor ": 2.1176274035231084, "Type 2 diabetes mellitus ": 2.077054226881724, "Underdose ": 2.7587993031230345, "Unemployment ": 53.00269818008081, "Urinary hesitation ": 4.544969972524501, "Ventricular arrhythmia ": 2.1243181289650934, "Violence-related symptom ": 6.051443351995413, "Weight fluctuation ": 5.700783215477451, "Weight increased ": 9.858281419258695, "Wound ": 5.417214867592367, "Wound complication ": 30.55285461905696, "Wrong technique in product usage process ": 3.3895779553668515} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/70.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/70.json new file mode 100644 index 00000000000..3db954d2d0f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/70.json @@ -0,0 +1 @@ +{"Balance disorder ": 34.13441854842257, "Blood calcium decreased ": 264.26574021931714, "Cognitive disorder ": 63.71014152609484, "Constipation ": 17.15046578978299, "Creatinine renal clearance decreased ": 334.2392335047507, "Creatinine renal clearance increased ": 909.540138114541, "Depressed level of consciousness ": 44.3927610565479, "Dyspnoea ": 3.196263937907502, "Fall ": 11.897991469564742, "Hypotension ": 11.708560867906748, "Mobility decreased ": 42.02602056409437, "Multiple drug therapy ": 1266.7035623438549, "Orthostatic hypotension ": 100.3802837771256, "Pain ": 3.943724599579484, "Product use in unapproved indication ": 3.1539639476941272, "Renal function test abnormal ": 236.61149787421976, "Sedation ": 111.98748844841803, "Sedation complication ": 362.1595705485053, "Toxicity to various agents ": 16.72914899626805} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/700.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/700.json new file mode 100644 index 00000000000..52f7df9ab56 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/700.json @@ -0,0 +1 @@ +{"Drug ineffective ": 2.348361662567159} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/701.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/701.json new file mode 100644 index 00000000000..c5f59688f1d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/701.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 8.203096816302743, "Abdominal pain lower ": 53.635991976801535, "Contusion ": 12.902804217982728, "Eye haemorrhage ": 77.41697412515178, "Hypoaesthesia ": 7.042494970994402, "Multiple sclerosis ": 92.35270030804791, "Musculoskeletal stiffness ": 12.858548505148864, "Vomiting ": 2.204069747062679} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/702.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/702.json new file mode 100644 index 00000000000..e1994314a43 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/702.json @@ -0,0 +1 @@ +{"Cardiomyopathy ": 117.02464658818084} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/703.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/703.json new file mode 100644 index 00000000000..c5eb0261c97 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/703.json @@ -0,0 +1 @@ +{"Acne ": 3.865636637777612, "Acute polyneuropathy ": 18.550491100071337, "Amylase increased ": 2.317058432512847, "Anaplastic thyroid cancer ": 107.3960896031414, "Aspartate aminotransferase increased ": 2.023352671061999, "BRAF V600E mutation positive ": 111.732402846743, "Blindness ": 2.3150491481420974, "Blindness unilateral ": 2.274405063755457, "Blood albumin decreased ": 2.0701002513827924, "Blood calcium increased ": 2.577697898592423, "Blood creatine phosphokinase increased ": 6.735145285361813, "Blood lactate dehydrogenase increased ": 4.528790580533598, "Blood sodium decreased ": 2.3583757126130926, "Body temperature fluctuation ": 3.6736529871470096, "Brain neoplasm ": 11.375793718285378, "Brain neoplasm malignant ": 10.109197679668249, "Brain oedema ": 2.949462287465767, "C-reactive protein increased ": 3.3208199504652347, "Cardiac dysfunction ": 4.445948014653985, "Cardiomyopathy ": 3.503776402091129, "Cardiotoxicity ": 4.198907467459966, "Cell death ": 4.750027300384772, "Central nervous system lesion ": 11.914530964391025, "Cerebral disorder ": 2.381488841366805, "Cholangitis ": 4.815352855375657, "Cholestasis ": 4.683314590844747, "Colon cancer ": 2.1869595158399298, "Concomitant disease aggravated ": 3.572676712201394, "Concomitant disease progression ": 4.156892797559645, "Cutaneous sarcoidosis ": 15.40497449953932, "Death ": 5.00117615218492, "Dehydration ": 2.5350056158082994, "Dermatitis acneiform ": 17.89565332767047, "Disease progression ": 3.087920370927154, "Disseminated intravascular coagulation ": 2.3933374034148223, "Drug resistance ": 2.039196824706073, "Dry skin ": 3.153320323456388, "Dysphagia ": 2.48122294134146, "Ejection fraction abnormal ": 7.852849835832617, "Ejection fraction decreased ": 20.20283254462189, "Electrolyte imbalance ": 2.3677905708133062, "Encephalitis ": 2.754156714888123, "Erythema nodosum ": 21.6150175839276, "Eye disorder ": 2.170084256193644, "Fistula ": 3.3935040049406746, "General physical health deterioration ": 2.091430168229065, "Glioma ": 40.09074554321754, "Haemophagocytic lymphohistiocytosis ": 10.831384908967244, "Hepatic cytolysis ": 5.374563372540807, "Hepatic enzyme abnormal ": 2.606531854955437, "Hepatic lesion ": 3.5467034862827203, "Hepatitis ": 2.3985144491506976, "Hospice care ": 10.62283498436832, "Hospitalisation ": 2.455472691875326, "Hyperkeratosis ": 5.901501649971897, "Hyperpyrexia ": 4.269125840476595, "Hyperthermia ": 5.235849971520797, "Intestinal metastasis ": 21.687245922570543, "Intestinal perforation ": 3.960601882081469, "Iridocyclitis ": 3.4687485683041044, "Left ventricular dysfunction ": 2.192436164083205, "Lipase increased ": 3.830614050862919, "Liver disorder ": 2.676789269560892, "Liver function test increased ": 4.3246056087454114, "Lung adenocarcinoma ": 20.598264502973123, "Lung adenocarcinoma stage IV ": 47.45248308747861, "Lung neoplasm malignant ": 7.526168423111554, "Lung opacity ": 2.348278209407672, "Lymphocyte count decreased ": 3.5939439380494864, "Lymphoedema ": 3.579509541583436, "Macular oedema ": 4.772524171679895, "Malignant 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184.77386873663477, "Metastatic neoplasm ": 8.050283087717638, "Neoplasm ": 6.164231283551559, "Neutrophil count increased ": 3.194014718298717, "Non-small cell lung cancer ": 60.33700972276355, "Panniculitis ": 33.126236917580684, "Papilloedema ": 4.668197301718378, "Paronychia ": 3.3856004634457206, "Pneumonitis ": 3.779837005069093, "Polyneuropathy ": 2.351097961791508, "Product storage error ": 2.3554100402015554, "Product use in unapproved indication ": 5.589253280500519, "Protein total decreased ": 6.385838608670719, "Pulmonary mass ": 2.8087882270481943, "Pyrexia ": 3.2013586110704533, "Rash maculo-papular ": 2.3701106085002603, "Rash pustular ": 2.5146215323180927, "Recurrent cancer ": 14.22858399655825, "Retinal detachment ": 13.613952438710836, "Retinal vein occlusion ": 3.334135001803889, "Retinopathy ": 4.503406878502394, "Rhabdomyolysis ": 5.105861713078274, "Sarcoidosis ": 6.378226086359593, "Second primary malignancy ": 13.001679803304334, "Serous retinal detachment ": 37.03445642689844, "Skin cancer ": 2.330630129479124, "Skin lesion ": 2.5095559123046605, "Skin mass ": 3.649676029315638, "Skin toxicity ": 6.592807795233899, "Soft tissue sarcoma ": 58.41541493545706, "Squamous cell carcinoma ": 4.031246219712018, "Squamous cell carcinoma of skin ": 4.642306902251658, "Systemic inflammatory response syndrome ": 3.8748247051520415, "Therapy partial responder ": 2.9612114573624844, "Thyroid cancer ": 4.020398599762232, "Tubulointerstitial nephritis ": 2.205861343676207, "Uveitis ": 28.61920950305159, "Ventricular hypokinesia ": 4.581137954754486, "Vision blurred ": 2.208958882173063, "Visual acuity reduced ": 2.6044406314163044, "Visual impairment ": 3.3629855414440617, "Vitiligo ": 5.293387619662759, "Vitreous floaters ": 3.790070874074254, "Vogt-Koyanagi-Harada disease ": 29.88034123290466} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/704.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/704.json new file mode 100644 index 00000000000..542528dacb2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/704.json @@ -0,0 +1 @@ +{"Abnormal dreams ": 7.342563868493295, "Acanthosis nigricans ": 233.18590181972124, "Accidental overdose ": 2.9186202413734117, "Aggression ": 4.994595058462952, "Agitation ": 3.7786953375078616, "Akathisia ": 4.804366691540161, "Alcoholism ": 33.60555518721919, "Appendicitis ": 7.715629821638753, "Appendicolith ": 23.776460596043343, "Ascites ": 2.2058623239586965, "Ataxia ": 4.14605254841787, "Bacterial infection ": 5.725215964894002, "Balance disorder ": 2.7099050798361635, "Behaviour disorder ": 4.079860722551242, "Blood cholesterol increased ": 2.141613949999428, "Blood prolactin increased ": 16.034255045091797, "Blood uric acid increased ": 8.691400737340238, "Cardiogenic shock ": 5.567231725404407, "Cardiomegaly ": 4.049634602542373, "Clavicle fracture ": 13.657087953362003, "Cognitive disorder ": 2.578429730851647, "Completed suicide ": 4.102613776946036, "Condition aggravated ": 2.0189659080269644, "Confusional state ": 2.133226659321523, "Constipation ": 2.9063461586420014, "Coordination abnormal ": 3.960724421100133, "Craniofacial fracture ": 28.912226248069658, "Delirium ": 3.2213387239742146, "Depressed level of consciousness ": 5.899756520856015, "Disorientation ": 3.252302476603136, "Distractibility ": 63.75139393289484, "Drug effective for unapproved indication ": 18.2963542504378, "Drug ineffective ": 2.430910298742029, "Drug ineffective for unapproved indication ": 7.517565391667079, "Drug interaction ": 2.2680173743331484, "Dry mouth ": 3.63572550439891, "Electrocardiogram QT prolonged ": 4.01986463270565, "Encephalopathy ": 2.2175173387228395, "Exercise tolerance decreased ": 4.117093602701224, "Exposure via breast milk ": 4.427784604890537, "Eyelid disorder ": 32.09815881046842, "Feeding disorder ": 3.120403623431516, "Feeling abnormal ": 3.2642761857077045, "Hallucination ": 3.950953057873376, "Hallucination, visual ": 4.104160179098392, "Hyperphosphataemia ": 32.79299335480949, "Hypersomnia ": 3.10700474972733, "Hyporeflexia ": 17.372796828632957, "Implant site infection ": 54.33093490658237, "Impulsive behaviour ": 19.403227347769885, "Incontinence ": 8.421779777177536, "Incorrect route of product administration ": 3.908664358311025, "Increased anteroposterior chest diameter ": 888.8504623211425, "Initial insomnia ": 10.813275526940268, "Insomnia ": 5.399498417560318, "Intentional overdose ": 25.59099691240368, "Intentional product misuse ": 4.24822352432333, "Intentional self-injury ": 106.75947978058886, "Irritability ": 2.756344921358165, "Joint range of motion decreased ": 4.003513871482803, "Judgement impaired ": 46.47530925376212, "Memory impairment ": 2.472631349724021, "Middle insomnia ": 46.09640544647803, "Myasthenia gravis ": 11.712335951291577, "Mydriasis ": 4.538616905507444, "Nightmare ": 16.003497676352573, "Obstructive sleep apnoea syndrome ": 13.340426662922388, "Overdose ": 2.4858812853342624, "Poisoning deliberate ": 6.507163746014482, "Poor quality sleep ": 8.041967535022787, "Product prescribing error ": 4.53425719078641, "Product use complaint ": 11.137790585126384, "Product use issue ": 2.4971311887244925, "Restless legs syndrome ": 2.562129463651672, "Rhonchi ": 36.05801041979489, "Sinus tachycardia ": 3.3746216081862626, "Skin disorder ": 2.2774617726156228, "Sleep apnoea syndrome ": 4.600863315791362, "Sleep disorder ": 7.625431222602592, "Somnolence ": 3.938401371397709, "Staphylococcal infection ": 2.246636484554279, "Suicide attempt ": 3.6527397080740527, "Suspected suicide ": 13.56006834994027, "Tardive dyskinesia ": 5.1147555069746025, "Therapeutic response decreased ": 4.485331955666212, "Toxicity to various agents ": 3.515408352386807, "Unevaluable event ": 5.301688634526713, "Vertigo ": 2.7152812272217086} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/705.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/705.json new file mode 100644 index 00000000000..6ce99989b3f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/705.json @@ -0,0 +1 @@ +{"Acute graft versus host disease ": 83.38739046895434, "Acute graft versus host disease in intestine ": 64.2556300606548, "Acute myeloid leukaemia ": 9.619746996967937, "Adenovirus infection ": 71.32142619791969, "Ascites ": 3.146105082320292, "Bacteraemia ": 11.243229974855714, "Blood lactate dehydrogenase increased ": 4.079842593434381, "Cardiac failure ": 2.6894368319022948, "Cardiac failure congestive ": 2.3555939028127857, "Cardiomyopathy ": 4.745125392259742, "Chronic graft versus host disease ": 29.982214913207343, "Clostridium difficile colitis ": 8.944070256971859, "Clostridium difficile infection ": 7.037641393385618, "Colitis ": 2.8259187327942668, "Congenital aplasia ": 35.090598327140405, "Cystitis haemorrhagic ": 19.226264651319976, "Cytomegalovirus infection ": 11.41128180888587, "Cytomegalovirus infection reactivation ": 47.8561605807521, "Cytomegalovirus viraemia ": 34.398773285034835, "Drug ineffective for unapproved indication ": 6.739094433697799, "Febrile neutropenia ": 20.356831366201032, "Graft versus host disease in skin ": 37.25819953393263, "Haemophagocytic lymphohistiocytosis ": 22.19933142471585, "Hepatic cytolysis ": 2.902636152879413, "Hepatitis B reactivation ": 17.29619037851157, "Human herpesvirus 6 infection ": 85.5061207606328, "Hypervolaemia ": 12.324453460790409, "Hypoxia ": 3.2047242109656606, "Incorrect product administration duration ": 7.582793937870976, "Incorrect route of product administration ": 7.8080470551423025, "Iris atrophy ": 421.6769635803152, "Meningitis bacterial ": 54.39845061524957, "Mucosal inflammation ": 29.711473393345468, "Multiple organ dysfunction syndrome ": 7.120862460936055, "Myelodysplastic syndrome ": 18.383451752961964, "Neuropathy peripheral ": 3.499748097091025, "Neutropenia ": 5.420717624557706, "Neutropenic colitis ": 60.461402812124255, "Off label use ": 5.628906474723544, "Pancytopenia ": 7.517998685250997, "Plasma cell myeloma ": 17.811635782609535, "Pleural effusion ": 3.263682816630683, "Pneumonia fungal ": 27.487919385052948, "Product use in unapproved indication ": 4.750421211272868, "Pulmonary hypertension ": 6.042918517704777, "Respiratory failure ": 3.8326384878593664, "Retinal degeneration ": 124.06161256418096, "Sepsis ": 3.486285435335649, "Septic shock ": 7.366596790929221, "Staphylococcal infection ": 4.4873874708435535, "Stomatitis ": 5.63676359675866, "Thrombocytopenia ": 4.619457551631856, "Thrombotic microangiopathy ": 57.31363703392644, "Venoocclusive liver disease ": 92.23983851412775, "Viraemia ": 69.34003307326786} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/706.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/706.json new file mode 100644 index 00000000000..e1ca173a150 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/706.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 7.068974726541299, "Aggression ": 15.149752151390114, "Agitation ": 9.545415854045324, "Altered state of consciousness ": 2.7660166607834733, "Anal incontinence ": 19.12740493642513, "Bradycardia ": 3.785151795454595, "Cardiac failure congestive ": 4.316877947941692, "Cerebrovascular accident ": 2.2962330139238576, "Cognitive disorder ": 3.068364178773824, "Confusional state ": 4.257124430776476, "Death ": 2.6635232559867386, "Dehydration ": 6.914077897941846, "Delirium ": 3.2981429538376545, "Dementia ": 8.75329344637986, "Dementia Alzheimer's type ": 18.50834631317517, "Dysphagia ": 2.5070819687613435, "Electrocardiogram QT prolonged ": 3.4258917463075487, "Fall ": 5.643826753833273, "Gait disturbance ": 3.2962636372886243, "Generalised tonic-clonic seizure ": 3.6486530029508257, "Hallucination ": 3.1470164016387168, "Hallucination, visual ": 5.846093479961975, "Hyponatraemia ": 2.622407360299305, "International normalised ratio increased ": 2.9070948684615576, "Lethargy ": 2.304281742699432, "Mental status changes ": 7.662391456502933, "Myoclonus ": 13.408167635860384, "Pneumonia aspiration ": 7.397405507474271, "Psychomotor hyperactivity ": 7.743706531478124, "Seizure ": 3.826773694336912, "Somnolence ": 2.310396567725583, "Syncope ": 2.218647255873932, "Transient ischaemic attack ": 4.296264435910807, "Treatment failure ": 2.2051036223215963, "Urinary incontinence ": 8.13235659100843, "Urinary tract infection ": 6.981592341460958} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/707.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/707.json new file mode 100644 index 00000000000..677c3ac1458 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/707.json @@ -0,0 +1 @@ +{"Erythema ": 3.484759199449172, "Febrile convulsion ": 44.19335513431783, "Injection site erythema ": 9.239081312419753, "Injection site swelling ": 6.5697580854623325, "Injection site warmth ": 9.453555700609286, "Pyrexia ": 4.403847995145165, "Rash ": 2.6228793186739803, "Urticaria ": 3.650229929913085} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/708.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/708.json new file mode 100644 index 00000000000..b2252cc09bb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/708.json @@ -0,0 +1 @@ +{"Blood pressure decreased ": 2.278941399083135, "Bronchiolitis ": 52.96407928467741, "Cellulitis ": 14.478336598434163, "Cyanosis ": 2.1835449777317977, "Dyskinesia ": 3.2774674902731102, "Eating disorder ": 6.579215815227368, "Erythema ": 5.466266583215194, "Extensive swelling of vaccinated limb ": 15.1349492679496, "Eye movement disorder ": 10.952024416446344, "Febrile convulsion ": 4.8867043759076685, "Flushing ": 4.363958105086375, "Guillain-Barre syndrome ": 5.002027772462974, "Head injury ": 5.515812438376587, "Heart rate decreased ": 3.1463137600313003, "Hyperpyrexia ": 9.755469328811758, "Hypotonia ": 4.567090848444231, "Induration ": 23.65567321618604, "Inflammation ": 8.721181010352149, "Injected limb mobility decreased ": 9.48919609341109, "Injection site erythema ": 5.153677110621563, "Injection site induration ": 7.687753755446627, "Injection site oedema ": 17.455522973032824, "Injection site pruritus ": 2.2141612325441598, "Injection site reaction ": 2.547688211026684, "Irritability ": 3.849798913321313, "Local reaction ": 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3.3443448879763653, "Upper respiratory tract infection ": 2.9832453852425265, "Urticaria ": 2.128916200330295, "Vaccination site cellulitis ": 149.46037768367236, "Vaccination site erythema ": 10.109563158396892, "Vaccination site induration ": 38.6015465631628, "Vaccination site inflammation ": 8.020744994118138, "Vaccination site joint swelling ": 65.08829983941715, "Vaccination site oedema ": 47.43242298537725, "Vaccination site pain ": 2.1860909693921133, "Vaccination site pruritus ": 2.9704376801071093, "Vaccination site reaction ": 4.241963285669499, "Vaccination site swelling ": 5.737976516164305, "Vaccination site warmth ": 15.74673184308442, "Viral infection ": 3.609901953220176} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/709.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/709.json new file mode 100644 index 00000000000..8ce2ad860e9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/709.json @@ -0,0 +1 @@ +{"Abnormal sensation in eye ": 11.515727471543787, "Accident ": 3.301851753700737, "Addison's disease ": 45.041835121308175, "Adrenal insufficiency ": 4.271972979015433, "Adverse drug reaction ": 6.003095183699547, "Airway remodelling ": 95.16366625481815, "Allergic sinusitis ": 85.20755279076121, "Aortic stenosis ": 6.979657621364519, "Aortic valve disease ": 8.870624782641633, "Appetite disorder ": 6.230200995265609, "Aspergillus infection ": 5.681323653147612, "Asphyxia ": 3.860338665188433, "Asplenia ": 184.3753193869933, "Asthma ": 32.75679986943822, "Asthmatic crisis ": 25.428405385345503, "Atelectasis ": 2.044985143358633, "Atrial septal defect ": 2.81266688987522, "Bacterial infection ": 8.887497859691383, "Blood immunoglobulin E increased ": 19.54803941744244, "Blood immunoglobulin M decreased ": 66.63538729671635, "Blood pressure abnormal ": 2.323688576289395, "Blood pressure increased ": 3.0013009219955125, "Blood pressure systolic decreased ": 2.070709567079417, "Blood test abnormal ": 5.704911127696822, "Breast disorder ": 22.839437839806884, "Breast neoplasm ": 13.89880765352929, "Breast operation ": 24.34012161284911, "Breath sounds abnormal ": 13.195933817245791, "Bronchial hyperreactivity ": 6.580119315673018, "Bronchial obstruction ": 97.43421844921116, "Bronchial secretion retention ": 11.529871446452535, "Bronchial wall thickening ": 7.4445153590315325, "Bronchiectasis ": 8.809644625387556, "Bronchiolitis ": 2.0523245159007684, "Bronchitis ": 4.066870378386263, "Bronchitis chronic ": 4.891488166384924, "Bronchopulmonary aspergillosis allergic ": 15.12851016024404, "CFTR gene mutation ": 2174.127046778093, "Cardiac ablation ": 14.567507667419768, "Cardiac murmur ": 3.9450835934059305, "Cataract ": 2.144824758490625, "Cataract operation ": 3.76089216217782, "Chemotherapy ": 5.6393262222795775, "Chest X-ray abnormal ": 3.871594276572379, "Chest 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"Eosinophilia ": 2.253313289091563, "Eosinophilic bronchitis ": 58.02955460244365, "Eosinophilic granulomatosis with polyangiitis ": 5.617161210626048, "Escherichia infection ": 2.8169032388506934, "Exposure to SARS-CoV-2 ": 46.01003521532816, "Extra dose administered ": 2.6112144004334747, "Eye irritation ": 2.1540413066700155, "Eye pruritus ": 8.67638608415968, "FEV1/FVC ratio decreased ": 50.55608645688515, "Feeding disorder ": 5.228702119655191, "Flank pain ": 2.9250859050954965, "Forced expiratory volume abnormal ": 53.1521762333382, "Forced expiratory volume decreased ": 5.025501050625416, "Frustration tolerance decreased ": 2.8992863653286145, "Full blood count abnormal ": 30.025746739401605, "Fungal infection ": 5.48827309614363, "Gait inability ": 2.3049845961166917, "Gastrointestinal obstruction ": 15.247776576126975, "Gastrooesophageal reflux disease ": 2.4684664846831663, "General physical condition abnormal ": 3.0153835563807547, "Glaucoma ": 8.813482547086736, "Granuloma ": 10.26227057793576, "Haemoglobin abnormal ": 4.503253390975902, "Head discomfort ": 2.147052489257701, "Heart sounds ": 95.0641364361324, "Hepatic cyst ": 7.429126593250801, "Hospitalisation ": 4.224066325036662, "Hyperaemia ": 9.012246343986456, "Ill-defined disorder ": 2.541509423199464, "Immunoglobulins increased ": 48.167893669448745, "Inappropriate schedule of product administration ": 4.133627515147525, "Increased bronchial secretion ": 21.032245913482697, "Infection ": 3.690326293272443, "Influenza ": 2.9302143865762544, "Intentional dose omission ": 7.077536511994595, "Intestinal haemorrhage ": 5.839601293681031, "Intestinal stent insertion ": 581.5570786562088, "Kyphosis ": 11.514333265814438, "Laboratory test abnormal ": 5.055496838437614, "Labyrinthitis ": 9.844129040870063, "Lip pruritus ": 18.598154005894145, "Lipohypertrophy ": 10.58935036183204, "Loss of personal independence in daily activities ": 25.248698951458405, "Lower respiratory tract congestion ": 12.116768442813347, "Lower respiratory tract infection ": 8.454618242478228, "Lumbar vertebral fracture ": 3.095252352220609, "Lung diffusion disorder ": 45.47689497459437, "Lung hyperinflation ": 15.38863402841734, "Lung opacity ": 3.523286704059034, "Lymphadenopathy mediastinal ": 9.329706973203116, "Macrocytosis ": 10.842457184564276, "Magnetic resonance imaging heart ": 108.46702368418488, "Middle insomnia ": 12.0458594243768, "Mite allergy ": 15.757386825678555, "Monocyte count increased ": 3.7617063447774512, "Mucosal disorder ": 4.484793931896532, "Multiple allergies ": 17.889475495498083, "Musculoskeletal chest pain ": 8.132743216889573, "Mycobacterium avium complex infection ": 17.91529315822425, "Nasal congestion ": 7.530938140948781, "Nasal discharge discolouration ": 148.91171148216262, "Nasal disorder ": 5.790630077018108, "Nasal obstruction ": 5.129680157424341, "Nasal polyps ": 5.169910165821498, "Nasopharyngitis ": 5.766419129305357, "Nerve compression ": 4.549972307157433, "Neurosensory hypoacusis ": 31.64167749954049, "Obstruction ": 13.535249459310538, "Obstructive airways disorder ": 33.70875074627306, "Ocular discomfort ": 14.676213678293555, "Ocular hyperaemia ": 6.117970676065559, "Oesophageal polyp ": 131.71038952237984, "Oropharyngeal pain ": 2.3394195407731893, "Otitis media ": 2.5308737787287137, "Oxygen saturation abnormal ": 4.304199607577753, "Oxygen saturation decreased ": 3.1686839029537186, "Pancreatitis relapsing ": 25.943104994050174, "Perfume sensitivity ": 41.02014716286871, "Pneumonia ": 5.071873202237676, "Pneumonia respiratory syncytial viral ": 30.23540190848667, "Polymyalgia rheumatica ": 2.648258949268122, "Polyp ": 22.05448892182321, "Post-traumatic stress disorder ": 6.672711702534168, "Presbyacusis ": 26.942616045164947, "Product administration error ": 2.2545662490435574, "Product dose omission issue ": 4.352064644506198, "Productive cough ": 20.413055348865477, "Prolonged expiration ": 64.75583166018866, "Prostatic disorder ": 5.523539286681516, "Pulmonary congestion ": 2.0375779091566675, "Pulmonary eosinophilia ": 19.24550781904297, "Pulmonary function test abnormal ": 10.90099661436422, "Pulmonary mass ": 9.745079026609538, "Rales ": 21.582549911627225, "Rectal cancer ": 8.737845000337044, "Red blood cell count increased ": 9.152397548808349, "Reflux laryngitis ": 56.16086402178681, "Respiration abnormal ": 5.897630707723087, "Respiratory disorder ": 4.641953314301232, "Respiratory gas exchange disorder ": 39.55302457394728, "Respiratory rate increased ": 2.1421562914260424, "Respiratory symptom ": 10.737940061205052, "Respiratory tract congestion ": 14.855088238881269, "Respiratory tract infection ": 6.46393081707223, "Reversible airways obstruction ": 165.91041215958182, "Rhinitis ": 7.544861199545633, "Rhinorrhoea ": 5.1193576864398125, "Right ventricular dysfunction ": 11.446924330030573, "Sarcoidosis ": 3.1972066583225103, "Seasonal allergy ": 24.76085452096457, "Secretion 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"Therapy cessation ": 2.815014678550443, "Throat clearing ": 4.860631988550817, "Tooth extraction ": 2.3330810237935387, "Total lung capacity decreased ": 27.465068316865075, "Transient ischaemic attack ": 2.045139305106808, "Unevaluable event ": 2.07475202496778, "Upper respiratory tract infection ": 5.223758101595506, "Upper-airway cough syndrome ": 21.72670457495433, "Urethritis ": 13.163009888939, "Urine abnormality ": 3.943569849298, "Vaccination site haemorrhage ": 18.417433129844696, "Viral infection ": 7.512845545202341, "Vital capacity decreased ": 33.828378393225535, "Wheelchair user ": 16.213593498519252, "Wheezing ": 42.67550950733181, "Wound infection ": 6.128456544084177} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/71.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/71.json new file mode 100644 index 00000000000..afe0b78e2c5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/71.json @@ -0,0 +1 @@ +{"Depression ": 5.2904288142913645, "Drug resistance ": 27.7725328581426, "Hepatic enzyme increased ": 8.899852357985706, "Lipodystrophy acquired ": 147.90997635781167, "Non-alcoholic steatohepatitis ": 683.7381828613328} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/710.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/710.json new file mode 100644 index 00000000000..3ef63e8d875 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/710.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 7.297124029268871, "Acute lymphocytic leukaemia recurrent ": 18.277856129889, "Acute myeloid leukaemia ": 13.298400265273283, "Agranulocytosis ": 4.254285438140775, "Alanine aminotransferase increased ": 3.270414669057343, "Amylase increased ": 7.198305564678553, "Anaemia ": 2.068082146117088, "Bacteraemia ": 10.45845608051359, "Blood bilirubin increased ": 3.315554842848549, "Bone marrow failure ": 5.531587294169802, "Cholestasis ": 2.5692758690732536, "Colitis ulcerative ": 2.265380030791519, "Crohn's disease ": 6.492516271567511, "Cytomegalovirus chorioretinitis ": 56.61821124982143, "Cytomegalovirus infection ": 16.161915598474675, "Cytopenia ": 7.559227504848666, "Diarrhoea haemorrhagic ": 9.609224261998609, "Disease recurrence ": 5.336959603490218, "Drug-induced liver injury ": 4.53203541926135, "Exposure during pregnancy ": 2.5027456578084637, "Febrile neutropenia ": 48.199582006460346, "Haemoglobin decreased ": 2.8542490886318124, "Haemophagocytic lymphohistiocytosis ": 15.926663805086678, "Hepatic function abnormal ": 2.0764371786360987, "Hepatitis ": 2.245985655132154, "Hepatosplenic T-cell lymphoma ": 283.7303273000464, "Hepatotoxicity ": 11.327954826698743, "Hyperbilirubinaemia ": 5.766278859221334, "Jaundice ": 4.162901294072843, "Langerhans' cell histiocytosis ": 311.60788927957253, "Leukaemia recurrent ": 32.29158903987639, "Leukopenia ": 10.909300572773898, "Lipase increased ": 7.899123843845635, "Liver function test abnormal ": 4.525445890859405, "Lymphopenia ": 6.794389196299509, "Mental disorder ": 3.328053703309068, "Mouth ulceration ": 3.627643433409321, "Mucosal inflammation ": 5.434794374256518, "Myelodysplastic syndrome ": 4.931076439286908, "Myelosuppression ": 32.64145417093603, "Neutropenia ": 6.160829391152121, "Neutrophil count decreased ": 10.69729267415639, "Nodular regenerative hyperplasia ": 137.24568877727535, "Off label use ": 3.7911385634314994, "Pallor ": 2.6016607346539904, "Pancreatitis ": 6.481835431929405, "Pancreatitis acute ": 6.95560824244525, "Pancreatitis necrotising ": 25.499085566225485, "Pancytopenia ": 15.927044981458106, "Platelet count decreased ": 4.643078354051314, "Pneumocystis jirovecii pneumonia ": 5.673383651283134, "Product use issue ": 2.1919666233671906, "Sepsis ": 2.991423231014356, "Splenomegaly ": 4.737562928803312, "Stomatitis ": 2.3046891723574965, "Thrombocytopenia ": 2.2857107949690647, "Upper respiratory tract infection ": 3.0415188096971173, "Viral infection ": 4.01416988430293, "White blood cell count decreased ": 8.45404145884898} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/711.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/711.json new file mode 100644 index 00000000000..8442ede63aa --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/711.json @@ -0,0 +1 @@ +{"Herpes zoster ": 17.952416527121674, "Vaccination failure ": 3.301923646555068} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/712.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/712.json new file mode 100644 index 00000000000..dc3fcbdcaa1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/712.json @@ -0,0 +1 @@ +{"Cerebral haematoma ": 393.1247726909989, "Cerebral haemorrhage ": 179.7815841222343} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/713.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/713.json new file mode 100644 index 00000000000..4a683df7875 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/713.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.2104922963478755, "Acute kidney injury ": 2.232717283082681, "Altered state of consciousness ": 6.941119395343088, "Anuria ": 10.079941522585113, "Appetite disorder ": 12.024749024022574, "Blister ": 18.133870710081453, "Blister rupture ": 449.7576783969333, "Blood creatine phosphokinase increased ": 2.1680684738045417, "Blood glucose increased ": 4.824011318469732, "Blood ketone body increased ": 45.93996937265378, "Blood lactic acid increased ": 12.380623713043832, "Blood pressure systolic increased ": 12.905443169736596, "Blood thyroid stimulating hormone increased ": 22.850829720844008, "Cardiac failure ": 2.63676534816854, "Cerebral infarction ": 3.3476222809366543, "Cognitive disorder ": 4.855232540577087, "Concomitant disease aggravated ": 26.42028381085322, "Concomitant disease progression ": 22.234402459292085, "Constipation ": 2.742269283501876, "Decreased appetite ": 3.022270945845272, "Dehydration ": 5.848554704931077, "Dementia ": 5.124658783209105, "Dermatitis ": 6.074622979168644, "Dermatitis bullous ": 9.986265913816217, "Diabetes mellitus inadequate control ": 46.19856862577995, "Diabetic nephropathy ": 28.19550425164873, "Dyslipidaemia ": 36.77333980987071, "Eczema ": 4.663305494999279, "Eosinophilia ": 3.779736757670315, "Erythema ": 2.946051592165255, "Food allergy ": 21.643411920315177, "Gastrooesophageal reflux disease ": 3.853063278370715, "Glomerular filtration rate decreased ": 3.82382876781628, "Glycosylated haemoglobin increased ": 29.01814730792279, "Haematocrit decreased ": 10.207662634458815, "Haemoglobin decreased ": 2.2575391355425576, "Hepatic function abnormal ": 2.63039415612761, "Hepatic steatosis ": 16.351750291338135, "Hyperglycaemia ": 5.702916967877856, "Hyperkalaemia ": 3.837990250128751, "Hypoglycaemia ": 5.966320988171951, "Hypophagia ": 5.958762500351369, "Hypothyroidism ": 3.5956081282438097, "Inflammation ": 3.74834891863175, "Intercepted product prescribing error ": 103.4576834254992, "Lactic acidosis ": 37.51443785708738, "Lymphocyte count decreased ": 19.43411798016228, "Metabolic acidosis ": 4.27529891119734, "Metastases to liver ": 3.755512816027257, "Mucosal disorder ": 28.135875336172823, "Neutrophil count decreased ": 3.0516477482557485, "Pancreatic carcinoma ": 4.979488155907248, "Pancreatitis acute ": 4.618796183190683, "Papule ": 4.364007459109607, "Pemphigoid ": 186.7322681135001, "Physical deconditioning ": 29.53439335498188, "Prostate cancer ": 10.83510027665936, "Proteinuria ": 7.345176640142861, "Red blood cell count decreased ": 7.5991257544354385, "Renal impairment ": 6.583843222247448, "Respiratory syncytial virus infection ": 11.58714688475367, "Rhabdomyolysis ": 2.844466851094132, "SARS-CoV-2 test positive ": 3.699339718112823, "Shock ": 3.327023834886204, "Skin erosion ": 57.99069923596083, "Skin exfoliation ": 9.748322001508733, "Splenomegaly ": 15.579364799229324, "Tachypnoea ": 2.9277723342477344, "Tonsil cancer ": 142.19237395618146, "Treatment noncompliance ": 3.459413085796258, "Tuberculosis ": 20.661724594586023, "Type 2 diabetes mellitus ": 13.024930574956072, "Vitamin D deficiency ": 12.499801468984623, "Weight decreased ": 2.6985114210581203} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/714.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/714.json new file mode 100644 index 00000000000..f70f752aa83 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/714.json @@ -0,0 +1 @@ +{"Abscess ": 2.122205229408155, "Abscess limb ": 2.2822416028897563, "Action tremor ": 27.84286958552345, "Acute graft versus host disease ": 13.51308298186652, "Acute graft versus host disease in intestine ": 6.581540307748151, "Acute graft versus host disease in skin ": 10.958466725344543, "Acute lymphocytic leukaemia ": 4.344493844457715, "Acute myeloid leukaemia ": 4.306534482996878, "Acute respiratory distress syndrome ": 2.909579435012572, "Adenovirus infection ": 2.79352658759279, "Agranulocytosis ": 2.0361812506376182, "Airway remodelling ": 339.58378892615184, "Angiodysplasia ": 18.634936975850778, "Arthritis ": 3.6538095580888497, "Arthritis bacterial ": 11.7098688324948, "Arthritis infective ": 4.325801482980193, "Arthrodesis ": 14.677417560233964, "Aspergillus infection ": 3.070950899119901, "Atopy ": 153.53550276360943, "Atypical mycobacterial infection ": 5.047644442187632, "Autoinflammatory disease ": 29.169554532888203, "B-cell lymphoma ": 2.7643591427470477, "BK virus infection ": 4.770657727589728, "Bacteraemia ": 2.8035165209913875, "Bacterial infection ": 2.366458461609237, "Benign abdominal neoplasm ": 165.9414240888942, "Benign ovarian tumour ": 39.32899244457196, "Bicytopenia ": 2.3911908765952847, "Blood immunoglobulin E increased ": 12.2320088189661, "Blood iron decreased ": 4.2397270109538825, "Blood pressure diastolic abnormal ": 44.60910514567497, "Blood pressure diastolic decreased ": 9.399491748967844, "Blood pressure diastolic increased ": 12.986421946421276, "Blood pressure fluctuation ": 2.221300094559552, "Blood pressure systolic abnormal ": 39.57823648112768, "Blood pressure systolic increased ": 7.964291621386266, "Blood test abnormal ": 2.061911351679701, "Body temperature decreased ": 6.254419221704143, "Bone marrow failure ": 2.9496365084246565, "Bronchitis ": 3.2512474815829533, "Bronchopulmonary aspergillosis ": 2.549755574728489, "Bronchopulmonary dysplasia ": 11.590866869201236, "Bursa disorder ": 25.03159398630535, "C-reactive protein increased ": 2.931282845900943, "Cardiac septal defect ": 78.07940163432635, "Cardiotoxicity ": 2.213649456317265, "Catheter site pain ": 13.634770004585016, "Cell death ": 2.701128564906756, "Cellulitis ": 2.5520380525700643, "Central nervous system lymphoma ": 24.451601587179177, "Central nervous system mass ": 1229.3545372773394, "Cheilitis ": 5.041176657886832, "Cholelithiasis ": 2.0930801673690014, "Chondritis ": 79.55151568043685, "Chondrodermatitis nodularis chronica helicis ": 433.3969778062538, "Chronic graft versus host disease ": 5.662895687414068, "Chronic sinusitis ": 6.220702374888782, "Clinodactyly ": 16.890677860388443, "Cold urticaria ": 23.91936157796233, "Condition aggravated ": 2.670489593238829, "Congenital aplasia ": 3.298034464318245, "Congenital foot malformation ": 10.754129827194864, "Contusion ": 2.433857040288677, "Crohn's disease ": 2.009539107045673, "Cushingoid ": 6.302913247816661, "Cystitis ": 2.018333717302362, "Cystitis haemorrhagic ": 2.878927827237539, "Cytomegalovirus chorioretinitis ": 4.621902530687314, "Cytomegalovirus infection ": 2.704358660341864, "Cytomegalovirus infection reactivation ": 4.533693167267168, "Cytomegalovirus test positive ": 7.637652729705631, "Cytomegalovirus viraemia ": 4.04419748024166, "Dactylitis ": 15.335636897161702, "Dental restoration failure ": 39.22088388840281, "Dermatitis atopic ": 3.01407703555923, "Dermatitis exfoliative generalised ": 3.624599497675807, "Diaphragmatic disorder ": 11.402566925772032, "Diffuse alopecia ": 4.36622825250318, "Diffuse large B-cell lymphoma ": 4.2550864121936565, "Diffuse large B-cell lymphoma recurrent ": 8.067824499709847, "Disability assessment scale score increased ": 149.32577481034104, "Disease recurrence ": 2.145774538073849, "Disseminated intravascular coagulation ": 2.1577238682920936, "Disseminated tuberculosis ": 4.364934865312127, "Diverticulitis ": 4.263534888588175, "Drug clearance decreased ": 20.15825378359944, "Drug ineffective ": 2.608532987742045, "Drug ineffective for unapproved indication ": 2.650902310453519, "Drug resistance ": 2.2997523685923595, "Duodenitis ": 4.294912259135163, "Dyslipidaemia ": 2.4361771665827, "Ear infection ": 2.5140709592911725, "Encephalitis ": 3.267239466262561, "Endocarditis ": 2.2081796098312885, "Enthesopathy ": 3.1153764683877943, "Eosinophil count decreased ": 34.62703478432783, "Eosinophil count increased ": 6.440821610108237, "Eosinophilic granulomatosis with polyangiitis ": 8.405528270328112, "Eosinophilic myocarditis ": 77.54521044076739, "Eosinophilic pneumonia ": 11.611539858685896, "Epigastric discomfort ": 4.274281154185458, "Epstein-Barr virus associated lymphoproliferative disorder ": 9.562356267342984, "Epstein-Barr virus infection ": 2.349490599655975, "Epstein-Barr virus infection reactivation ": 6.482839888090762, "Erysipelas ": 2.936882119576772, "Escherichia urinary tract infection ": 4.667647904540283, "Eustachian tube dysfunction ": 19.56749366796689, "Febrile bone marrow aplasia ": 8.05808736448486, "Febrile neutropenia ": 5.939602253351101, "Fibromyalgia ": 5.409520646046038, "Fine motor skill dysfunction ": 2.601177752903931, "Finger deformity ": 2.205163117056464, "Follicular lymphoma ": 6.749275816961422, "Food allergy ": 3.545669948095321, "Foot deformity ": 3.603022210928081, "Fungal infection ": 4.672353284830303, "Gastroenteritis ": 2.212072920442408, "Graft versus host disease ": 4.565569365925122, "Graft versus host disease in gastrointestinal tract ": 4.449219040248449, "Graft versus host disease in skin ": 4.513754711445736, "Granulocytopenia ": 2.2536571219641703, "Grip strength decreased ": 29.255564376239136, "Growth retardation ": 6.372239753599802, "Haematotoxicity ": 2.695406933591852, "Haemoglobin increased ": 2.530238492929478, "Haemophagocytic lymphohistiocytosis ": 3.399820832663249, "Haemorrhagic disease of newborn ": 146.23141070904936, "Heart rate decreased ": 3.823242509053709, "Hepatic cirrhosis ": 2.402973221822516, "Hepatic cytolysis ": 3.384673012885153, "Hepatic enzyme abnormal ": 2.7086943387108438, "Hepatic enzyme increased ": 2.4627770087137715, "Hepatic fibrosis ": 3.11179458827036, "Hepatic steatosis ": 4.71717751563075, "Hepatitis ": 2.107396992549177, "Hepatitis B reactivation ": 7.572580587747764, "Hepatocellular injury ": 2.2773875282915883, "Hepatotoxicity ": 2.0846600525657006, "Hernia ": 2.0302163710272287, "Herpes simplex ": 3.795340454575125, "Herpes virus infection ": 2.6482337682729367, "Hiatus hernia ": 2.8967052859513065, "Hodgkin's disease ": 2.890843176311133, "Human papilloma virus test positive ": 5.461207995713782, "Hypersensitivity pneumonitis ": 5.647973478582461, "Hyperthermia malignant ": 4.156609620018274, "Hypertransaminasaemia ": 3.770724786589712, "Hypogammaglobulinaemia ": 5.217861004154536, "Hysterectomy ": 5.848384042759211, "Ichthyosis ": 37.07500869439725, "Illness ": 2.1048150467018893, "Immunosuppression ": 7.1884626568275305, "Infection ": 2.366666544110412, "Infusion related reaction ": 2.863534061549834, "Injection related reaction ": 2.80183805109018, "Interstitial lung disease ": 3.1066998989057337, "Intervertebral disc degeneration ": 2.230448978354386, "Joint destruction ": 7.382546500159423, "Joint effusion ": 5.324050424101543, "Joint stiffness ": 2.5267073441297434, "Joint swelling ": 4.705871396889209, "Kaposi's sarcoma ": 2.535430934241771, "Klebsiella infection ": 2.610137132189445, "Lacrimation increased ": 2.662963271355986, "Latent tuberculosis ": 8.986951198342148, "Leukaemia recurrent ": 9.15323382639019, "Leukoencephalopathy ": 17.08604728385845, "Leukopenia ": 3.176384803800352, "Ligament sprain ": 2.1705543009091555, "Limb mass ": 4.991275058257167, "Lip blister ": 5.037144722518463, "Lip injury ": 6.198313270573319, "Lip ulceration ": 6.239772171286459, "Localised infection ": 2.8038428788548546, "Loss of personal independence in daily activities ": 2.61209946774204, "Low density lipoprotein increased ": 2.966595679882067, "Lower respiratory tract congestion ": 18.264593881615117, "Lower respiratory tract infection ": 2.9778639035922114, "Lung adenocarcinoma ": 3.4577832475125985, "Lung consolidation ": 3.2079220134819004, "Lymphocyte count decreased ": 3.666409925860428, "Lymphoma ": 6.170391237017313, "Lymphopenia ": 5.689556556870365, "Lymphoproliferative disorder ": 37.01473173406536, "Magnetic resonance imaging abnormal ": 4.132993204264399, "Maternal exposure timing unspecified ": 5.702010758519705, "Microangiopathy ": 55.12684820623129, "Micrognathia ": 16.766266809103005, "Monocyte count increased ": 3.6640855520020255, "Morton's neuralgia ": 66.38308767528781, "Mouth ulceration ": 5.725417978367167, "Mucormycosis ": 4.1873357195622845, "Mucosal inflammation ": 6.074778511578046, "Muscle strain ": 3.617632397031544, "Musculoskeletal stiffness ": 2.890659585694976, "Myelodysplastic syndrome ": 2.3726271827000898, "Myelosuppression ": 5.883447214392253, "Nasal polyps ": 11.946702211061604, "Nasopharyngitis ": 3.237274759043305, "Necrotising fasciitis ": 2.4599786724159647, "Nephropathy toxic ": 2.1384798335530584, "Neurological decompensation ": 3.8714090403081256, "Neurotoxicity ": 2.313545862303196, "Neutropenia ": 2.657593509288287, "Neutropenic sepsis ": 7.470973468520317, "Neutrophil count decreased ": 2.716237198149511, "Nocardiosis ": 4.084859426525982, "Nodule ": 7.88998072764187, "Obesity ": 5.799859143616076, "Obstructive airways disorder ": 3.392206572951215, "Obstructive sleep apnoea syndrome ": 3.9948720926526544, "Oral herpes ": 2.1170145290911933, "Organising pneumonia ": 3.813203767555988, "Osteoarthritis ": 7.782439049524688, "Osteomyelitis ": 2.573782797896816, "Osteosarcoma ": 19.1398421968342, "Pancytopenia ": 7.106972193635807, "Pharyngitis ": 2.2388331904949275, "Pharyngitis streptococcal ": 3.105040603046501, "Photosensitivity reaction ": 2.380496607127948, "Pleurisy ": 3.2416719343756286, "Pneumatosis intestinalis ": 2.767444045561092, "Pneumocystis jirovecii pneumonia ": 13.386135596273306, "Pneumonia ": 2.1613951572911243, "Pneumonia bacterial ": 4.773284246319933, "Pneumonia cytomegaloviral ": 4.282878643601265, "Pneumonia fungal ": 4.121622652731253, "Pneumonia pneumococcal ": 4.958864340765277, "Pneumonitis ": 2.622805531827365, "Polyarthritis ": 3.1872655644592256, "Poor venous access ": 6.1303996282856295, "Post transplant lymphoproliferative disorder ": 4.8697238023389415, "Posterior reversible encephalopathy syndrome ": 6.247698308403684, "Postoperative wound infection ": 2.7115333809502022, "Product use in unapproved indication ": 2.394218057585121, "Productive cough ": 3.4274743557448204, "Progressive multifocal leukoencephalopathy ": 3.486667897006588, "Prostate cancer ": 2.986319699099029, "Pseudomonal bacteraemia ": 22.140759919258784, "Psoriasis ": 4.477999324788413, "Psoriatic arthropathy ": 6.121017501358987, "Pulmonary fibrosis ": 2.631852726935992, "Pulmonary toxicity ": 2.107913105681306, "Pulmonary tuberculosis ": 5.99254688417585, "Pulmonary vascular disorder ": 20.16678976526278, "Pyelonephritis ": 2.0914427937989326, "Rebound effect ": 6.54713590247154, "Red blood cell sedimentation rate increased ": 3.392075425820736, "Red cell distribution width increased ": 3.8916536283309098, "Renal disorder ": 2.22583144362492, "Respiratory symptom ": 17.53513735997219, "Respiratory tract congestion ": 2.605522694602895, "Respiratory tract infection ": 5.383637697661907, "Rhabdoid tumour ": 595.4633302978953, "Rheumatic disorder ": 2.565423139816607, "Rheumatoid arthritis ": 8.401388559503568, "Rheumatoid factor positive ": 2.507160281205742, "Rheumatoid nodule ": 17.952708853271382, "Rotator cuff repair ": 89.00792356516351, "Sarcoidosis ": 2.5206733875574825, "Scab ": 2.7699426964015026, "Second primary malignancy ": 2.266190270595195, "Sepsis ": 3.0208114548536757, "Septic shock ": 2.51473574896529, "Sinus congestion ": 2.541106465165386, "Sinusitis ": 2.014928352450434, "Skin abrasion ": 2.323556608149254, "Skin erosion ": 2.303265898630268, "Skin laceration ": 4.488539051743943, "Skin lesion ": 2.442156326896061, "Skin mass ": 2.0753808446780506, "Skin plaque ": 3.074013773105626, "Skin striae ": 4.224015695327822, "Sleep deficit ": 7.311567416306866, "Soft tissue swelling ": 12.658709017066622, "Spinal compression fracture ": 2.693235562519605, "Spinal stenosis ": 30.651788473055056, "Squamous cell carcinoma ": 3.1516098519335283, "Squamous cell carcinoma of the oral cavity ": 24.36838048705268, "Staphylococcal bacteraemia ": 3.0242383000642485, "Staphylococcal infection ": 2.679610827127905, "Staphylococcal sepsis ": 4.963234142527649, "Still's disease ": 11.21360636009102, "Stomatitis ": 2.782426752131696, "Streptococcal bacteraemia ": 11.687368563479223, "Stress ": 2.025588327997877, "Sweat gland tumour ": 58.27519382704307, "Syndactyly ": 6.558981165985358, "Synovitis ": 4.439000049782897, "Tenderness ": 11.126105987470062, "Therapeutic product effect incomplete ": 3.0071358602391656, "Therapeutic response decreased ": 3.5144034360343825, "Thrombotic microangiopathy ": 2.901458598411097, "Tooth abscess ": 8.726740897596994, "Transaminases increased ": 2.9807070703370773, "Treatment failure ": 6.266377635607415, "Tuberculosis ": 4.934652508115583, "Tumour lysis syndrome ": 2.831198008371969, "Umbilical hernia ": 3.0947730936955984, "Urinary tract infection bacterial ": 5.647778706045294, "Urinary tract infection pseudomonal ": 33.68296456542038, "Vaginal infection ": 4.382401532358941, "Vascular device infection ": 2.179155029112528, "Vasomotor rhinitis ": 78.17223334159516, "Venoocclusive disease ": 3.6738470418348266, "Venoocclusive liver disease ": 6.543758047401073, "Ventricular hypokinesia ": 2.60507311346161, "Viral haemorrhagic cystitis ": 8.128413012723303, "Viral infection ": 2.7474832173091137, "White blood cell count decreased ": 2.144316456136059} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/715.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/715.json new file mode 100644 index 00000000000..ff6b357d0da --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/715.json @@ -0,0 +1 @@ +{"Agitation ": 13.827537600908707, "Drug interaction ": 15.257888574229758, "Serotonin syndrome ": 224.85939299049392} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/716.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/716.json new file mode 100644 index 00000000000..4dfc496fe05 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/716.json @@ -0,0 +1 @@ +{"Arrhythmia ": 7.923941572518663, "Arrhythmic storm ": 2550.613125453545, "Cardiac failure ": 11.69400575669215, "Drug ineffective ": 10.963606883826143, "Seizure ": 2.761654251671553, "Torsade de pointes ": 60.34591175080017, "Ventricular fibrillation ": 43.55973498245247, "Ventricular tachycardia ": 61.56323827028558} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/717.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/717.json new file mode 100644 index 00000000000..ca466432047 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/717.json @@ -0,0 +1 @@ +{"Aspergillus infection ": 77.7193910044586, "C-reactive protein increased ": 6.414061249752139, "Candida infection ": 32.02128236375394, "Drug ineffective ": 7.443433649457482, "Drug resistance ": 9.014122277824814, "Eosinophil count increased ": 26.70384928505748, "Hepatic failure ": 11.50809851459593, "Hepatic function abnormal ": 9.703154620030972, "Hypokalaemia ": 5.424385890857232, "Infection ": 2.8467628129589446, "Mucormycosis ": 130.36712523267298, "Multiple organ dysfunction syndrome ": 9.906876627679932, "Off label use ": 3.054272491049891, "Pathogen resistance ": 31.156905845030607, "Pneumonia ": 2.8753094547954787, "Product use in unapproved indication ": 2.081444949468219, "Respiratory failure ": 7.31632086666999, "Therapy non-responder ": 9.206278891030497} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/718.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/718.json new file mode 100644 index 00000000000..7a199997fe0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/718.json @@ -0,0 +1 @@ +{"Accident at work ": 53.41992311586037, "Acute kidney injury ": 3.9574255881122657, "Angina pectoris ": 2.0719069499589384, "Angina unstable ": 2.4281032381504866, "Angioedema ": 5.930562057395212, "Anuria ": 4.070834331402571, "Apraxia ": 16.189786321376353, "Atrial fibrillation ": 2.293629862795349, "Atrioventricular block complete ": 3.53843112563667, "Atrophic vulvovaginitis ": 55.166066792057, "Bite ": 36.44823989957512, "Blood alkaline phosphatase increased ": 3.519377595266276, "Blood chloride decreased ": 11.733266164072802, "Blood cholesterol abnormal ": 7.818801728442826, "Blood creatine phosphokinase increased ": 5.519030324085107, "Blood creatinine increased ": 4.062612593620676, "Blood iron decreased ": 5.281402190095919, "Blood parathyroid hormone increased ": 16.67973220125753, "Blood phosphorus increased ": 8.19004069031512, "Blood potassium increased ": 12.643692887980867, "Blood pressure abnormal ": 4.16251540948135, "Blood pressure decreased ": 4.842245579076026, "Blood pressure diastolic abnormal ": 10.497054259539944, "Blood pressure fluctuation ": 6.198692505277972, "Blood pressure inadequately controlled ": 14.111349640701574, "Blood pressure increased ": 6.917219605308899, "Blood pressure systolic abnormal ": 19.63180176255119, "Blood pressure systolic increased ": 4.52435770638701, "Blood sodium decreased ": 5.391005174904916, "Blood sodium increased ": 13.96356574100327, "Blood urea increased ": 7.788732948248307, "Blood uric acid increased ": 6.080403160675028, "Bradycardia ": 3.81211456152521, "Cardiogenic shock ": 3.3317117032888097, "Cerebral infarction ": 2.075308215495137, "Cholelithiasis ": 2.0002320010327863, "Chromaturia ": 2.080576936172821, "Colitis ischaemic ": 2.4768976150401465, "Colon cancer ": 4.389582527467555, "Cough ": 2.0027531417427524, "Cystitis ": 3.1682360593041827, "Dementia ": 2.3369754469001798, "Dermatitis exfoliative generalised ": 2.991691199469896, "Diabetic foot ": 7.003755022381172, "Diabetic nephropathy ": 9.56806342607366, "Drug eruption ": 4.733788404851223, "Drug-induced liver injury ": 3.139033172190663, "Emphysema ": 2.652561792605161, "Erythema multiforme ": 2.914292761250428, "Face oedema ": 2.666401938327362, "Faeces discoloured ": 2.0672971101502875, "Fall ": 2.056881009636048, "Gamma-glutamyltransferase increased ": 2.3476808176981048, "Generalised oedema ": 2.3712598512539462, "Gout ": 2.1256618449660927, "Growth hormone deficiency ": 141.43696076294944, "Gynaecomastia ": 2.5876431706376444, "Heart rate decreased ": 2.7864702642518, "Hepatic function abnormal ": 6.410125701386251, "Hepatitis acute ": 2.887657515316995, "Hepatitis fulminant ": 4.730475042130308, "Hepatocellular injury ": 3.5332855053765573, "Hyperkalaemia ": 14.4966059202757, "Hypertension ": 2.3738624981221395, "Hypertensive crisis ": 10.890207669079608, "Hypertonic bladder ": 12.76128493142163, "Hyperuricaemia ": 4.241342658728513, "Hypoglycaemia ": 2.0675464773376917, "Hyponatraemia ": 4.029462864451151, "Hypotension ": 4.558775653912811, "Hypovolaemia ": 3.90426144568914, "Infarction ": 5.090403872455663, "Interstitial lung disease ": 5.720546157244377, "Iron deficiency anaemia ": 2.774504229906312, "Jaundice ": 4.340460678317132, "Jaundice cholestatic ": 3.599795558981817, "Laryngeal oedema ": 2.215425717480759, "Left ventricular hypertrophy ": 5.381877839465967, "Liver disorder ": 6.399679187593398, "Loss of consciousness ": 2.2733326443293045, "Lung neoplasm malignant ": 2.2355367858452704, "Lymphocyte stimulation test positive ": 28.22185375056543, "Myocardial infarction ": 2.2968766678505657, "Nocturia ": 3.129573074762157, "Oedema peripheral ": 2.1783737509121246, "Orthostatic hypotension ": 7.423467141442469, "Pancreatic carcinoma stage III ": 212.43699148382075, "Pharyngeal oedema ": 5.952274516129602, "Pneumonia bacterial ": 4.173946467813583, "Product physical issue ": 2.749569767991811, "Product quality issue ": 2.769245848251092, "Pulmonary hypoplasia ": 33.60099092924455, "Rales ": 2.4997666088771604, "Renal artery stenosis ": 16.87920973434076, "Renal impairment ": 3.92047229222548, "Renal tubular necrosis ": 2.1123054684252303, "Rhabdomyolysis ": 5.05372756229684, "Road traffic accident ": 2.2818473215865467, "Shock ": 2.623139078968608, "Sinus node dysfunction ": 7.239345476126208, "Sjogren's syndrome ": 5.987998800269721, "Skin laceration ": 2.3016414544571653, "Stevens-Johnson syndrome ": 2.0262689667685527, "Syncope ": 2.355347912472822, "Tendonitis ": 2.7738688039730124, "Therapy non-responder ": 2.519897007988937, "Thrombocytopenic purpura ": 5.824137463988968, "Toxic skin eruption ": 3.1440399303818216} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/719.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/719.json new file mode 100644 index 00000000000..96a02f35ee0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/719.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 5.897491265979695, "Angioedema ": 2.5709492481470337, "Balance disorder ": 2.647555381000082, "Blood potassium decreased ": 8.607866497485936, "Blood pressure decreased ": 3.765903671417778, "Blood pressure increased ": 2.8455345326658343, "Cough ": 2.0341130240043888, "Dry mouth ": 4.474405118016654, "Electrolyte imbalance ": 16.370008908521847, "Erectile dysfunction ": 11.784280346717562, "Fall ": 2.9352075653624885, "Hyperkalaemia ": 8.32197494230159, "Hypertensive crisis ": 13.864332829667823, "Hyperuricaemia ": 56.98978011291496, "Hypokalaemia ": 6.3623501141381125, "Hyponatraemia ": 36.229688108395926, "Hypotension ": 9.432426115948225, "Inappropriate antidiuretic hormone secretion ": 15.451594909593137, "Lactic acidosis ": 7.595427151077852, "Orthostatic hypotension ": 14.462220024742669, "Pancreatitis ": 2.8276290756533724, "Photosensitivity reaction ": 10.022856636163448, "Presyncope ": 8.445860528172176, "Syncope ": 4.372505665074195, "Vertigo ": 3.2191524161022684} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/72.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/72.json new file mode 100644 index 00000000000..6d71e05288b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/72.json @@ -0,0 +1 @@ +{"Anaemia ": 4.594814524997642, "Bradycardia ": 7.792302572196986, "Drug ineffective ": 2.3448740544693165, "Drug intolerance ": 9.591486456677035, "Dysaesthesia ": 73.24290938521547, "Haemoglobin decreased ": 11.317748609915052, "Myelofibrosis ": 245.4323693937629, "Paraesthesia ": 2.340609127628494, "Platelet count decreased ": 6.713019868553475, "Platelet count increased ": 70.73577353593751, "Sedation ": 29.8445940125878, "Somnolence ": 2.740874758088238, "Splenomegaly ": 66.15655087495634, "Vertigo ": 5.578272728764781} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/720.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/720.json new file mode 100644 index 00000000000..ab3d0dce8ed --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/720.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 2.134830258057685, "Abortion induced ": 2.3308733405785, "Accidental overdose ": 3.2772688344760272, "Acidosis ": 3.491393240837627, "Acute generalised exanthematous pustulosis ": 4.007620142677752, "Acute pulmonary oedema ": 7.090307550211025, "Acute respiratory distress syndrome ": 4.233937740702786, "Acute respiratory failure ": 2.1240334981939646, "Aggression ": 2.5617096540558792, "Agitation ": 7.0282104316902245, "Airway complication of anaesthesia ": 85.7424050434213, "Altered state of consciousness ": 4.247545105585105, "Amino acid level increased ": 115.61316650366412, "Anaesthetic complication ": 17.363640920387503, "Anaesthetic complication neurological ": 638.7951811642432, "Anaphylactic reaction ": 10.714035223382403, "Anaphylactic shock ": 14.79348965057818, "Anaphylactoid reaction ": 8.223422863063975, "Anaphylactoid shock ": 26.216892794461685, "Anticholinergic syndrome ": 19.5927804513776, "Anuria ": 2.128129514204692, "Aortic valve incompetence ": 5.580864451503178, "Apgar score low ": 22.055562715950764, "Apnoea ": 16.42994024524625, "Apnoeic attack ": 29.364445466068627, "Areflexia ": 6.259808284129397, "Arteriospasm coronary ": 6.9711217604801305, "Aspiration ": 12.898824435837671, "Atelectasis ": 4.135318789284506, "Atrioventricular block ": 4.919717117374876, "Autonomic nervous system imbalance ": 8.422349659448837, "Blood bicarbonate decreased ": 11.685211860895532, "Blood calcium decreased ": 2.305060839480027, "Blood creatine phosphokinase increased ": 2.304687369559464, "Blood lactic acid increased ": 3.992186126185759, "Blood magnesium decreased ": 10.386767069033883, "Blood pH decreased ": 11.784678206314409, "Blood pressure decreased ": 3.6412948202447617, "Blood pressure immeasurable ": 23.64965313822041, "Blood pressure systolic decreased ": 9.454372172298322, "Blood sodium increased ": 12.322947252034432, "Bradycardia ": 6.083821605242825, "Bradycardia foetal ": 12.967504067582851, "Bradypnoea ": 13.7373675721881, "Brain death ": 13.21952862325068, "Brain injury ": 3.785393758160047, "Brain oedema ": 6.965477575144787, "Bronchoalveolar lavage abnormal ": 116.80149055447076, "Bronchospasm ": 10.829179709070996, "Caesarean section ": 4.137747097828348, "Cardiac arrest ": 8.956067360263303, "Cardio-respiratory arrest ": 5.166935993950047, "Cardiogenic shock ": 4.965314184854846, "Cardiomegaly ": 3.990734874356425, "Cardiopulmonary failure ": 4.795883744671636, "Cardiovascular insufficiency ": 7.11352083653256, "Cerebral atrophy ": 25.500959837984773, "Cerebral haemorrhage ": 2.120634154303149, "Cerebral haemorrhage foetal ": 226.19706200438043, "Cholestasis ": 4.444385194684785, "Circulatory collapse ": 4.2884347708225645, "Clonus ": 15.327477980575472, "Coma ": 6.380361981717264, "Coma scale abnormal ": 6.312785515866044, "Completed suicide ": 2.421722181057914, "Cyanosis ": 2.1236655575099395, "Deafness unilateral ": 3.3243087264971245, "Delayed recovery from anaesthesia ": 30.52847124930358, "Delirium ": 5.536483393001786, "Depressed level of consciousness ": 6.009667076279464, "Dermatitis allergic ": 3.1203076095173974, "Device related sepsis ": 18.09468777224527, "Diabetes insipidus ": 10.111722140553178, "Disseminated intravascular coagulation ": 3.650980435261428, "Drug abuse ": 3.74175798285502, "Drug diversion ": 7.726450048267389, "Drug ineffective for unapproved indication ": 2.849659646549826, "Drug interaction ": 3.5969596426390607, "Drug level increased ": 2.180560657222442, "Dyskinesia ": 3.587014186919083, "Dystonia ": 7.298356964346864, "Electrocardiogram QRS complex prolonged ": 7.360294660049282, "Electrocardiogram QT prolonged ": 2.3417716922055867, "Electrocardiogram ST segment elevation ": 11.507383922643507, "Electrocardiogram abnormal ": 3.972165131935523, "Electroencephalogram abnormal ": 16.373418698651413, "Encephalopathy ": 4.751640521574726, "Endotracheal intubation ": 5.455276681256489, "Exposure during pregnancy ": 2.360164679340845, "Exposure via breast milk ": 2.1679364316044296, "Extensor plantar response ": 28.5798163757589, "Extrasystoles ": 2.38297051537289, "Fibrinolysis ": 231.08493038647677, "Foetal death ": 7.863048526906474, "Foetal exposure during delivery ": 32.37946294066199, "Foetal exposure during pregnancy ": 4.222672279177228, "Foetal growth restriction ": 14.83003429392651, "Generalised tonic-clonic seizure ": 5.0388484692847335, "Grimacing ": 42.87806276964111, "Haemodynamic instability ": 18.69064788305545, "Hallucination ": 3.127397232006629, "Heart rate decreased ": 4.695325103821082, "Hepatic cytolysis ": 3.158776278356403, "Hiccups ": 2.8204241834172783, "Hydrothorax ": 21.10882132128616, "Hypercapnia ": 25.769717377265444, "Hyperreflexia ": 3.801511957690943, "Hyperthermia ": 6.094639495203747, "Hyperthermia malignant ": 47.17750809826777, "Hypertonia ": 8.426245774606347, "Hypopnoea ": 4.02092944542596, "Hypotension ": 6.600568184509002, "Hypothermia ": 3.0011687092186925, "Hypotonia ": 2.682739318414337, "Hypoventilation ": 31.46992846166537, "Hypovolaemic shock ": 5.578067120436186, "Hypoxia ": 7.946184836165208, "Hypoxic-ischaemic encephalopathy ": 13.915744659229526, "Ileus paralytic ": 7.676027778333676, "Incorrect drug administration rate ": 11.222394195799463, "Incorrect route of product administration ": 4.741102060308593, "Increased bronchial secretion ": 9.80254338599024, "Infantile apnoea ": 31.11785217764841, "Infusion site erythema ": 7.584866298569876, "Injection site urticaria ": 4.449521590604828, "Intentional overdose ": 2.247905576431754, "Intentional product misuse ": 4.460550945793516, "Intracranial pressure increased ": 4.731303430529409, "Kounis syndrome ": 16.56913123992617, "Laryngospasm ": 7.146323346559651, "Left ventricular dysfunction ": 8.197942745723498, "Left ventricular hypertrophy ": 4.096070028400209, "Leukocytosis ": 2.728538967873844, "Lip oedema ": 2.599667521392922, "Mechanical ventilation complication ": 78.83418505750022, "Medication error ": 2.2694086075189874, "Mental status changes ": 2.465309056845878, "Metabolic acidosis ": 6.131424777076011, "Miosis ": 5.535696703805512, "Mononucleosis syndrome ": 226.59276516001088, "Movement disorder ": 3.2797285819601587, "Multiple organ dysfunction syndrome ": 2.650422557865285, "Multiple-drug resistance ": 10.670049301128088, "Mumps ": 18.372625791282527, "Muscle rigidity ": 5.452083975718347, "Mydriasis ": 5.782620041476337, "Myoclonus ": 7.981299992959979, "Nephrogenic diabetes insipidus ": 7.828645544382011, "Nerve injury ": 2.6035976497468103, "Nervous system disorder ": 2.526842079333527, "Normal newborn ": 4.363273233136822, "Nystagmus ": 18.00325735264516, "Oliguria ": 3.1682871995420645, "Orthopnoea ": 5.3724385515650965, "Overdose ": 3.854359542732952, "Oxygen saturation abnormal ": 11.04670330123272, "Oxygen saturation decreased ": 10.08318538212028, "PCO2 increased ": 88.88622571793454, "PO2 increased ": 67.08828438022006, "Paradoxical drug reaction ": 32.84851213305368, "Partial seizures ": 9.50264505072604, "Pneumothorax ": 2.8169399658541883, "Poisoning ": 6.547846293031295, "Poisoning deliberate ": 8.142820011314287, "Poor feeding infant ": 17.71409520889765, "Post procedural haemorrhage ": 2.40358989308267, "Postoperative delirium ": 40.88554487595712, "Potentiating drug interaction ": 4.55981190567656, "Premature baby ": 2.1105320507358947, "Premature delivery ": 2.2668278066916305, "Product administered to patient of inappropriate age ": 4.788238682462222, "Product contamination physical ": 44.27052488058702, "Propofol infusion syndrome ": 15.999732858016284, "Psychomotor hyperactivity ": 5.474875171976252, "Pulmonary hypertensive crisis ": 82.23507540598621, "Pulmonary oedema ": 2.899821349568149, "Pulmonary toxicity ": 2.8981808990452955, "Pulmonary vascular disorder ": 73.89671725978071, "Pulse absent ": 11.9988486016156, "Pulseless electrical activity ": 15.491618592603688, "Pupillary reflex impaired ": 17.40373183429188, "Quadriplegia ": 12.419381586591715, "Rash maculo-papular ": 2.5828295005712776, "Renal ischaemia ": 56.07505156395093, "Respiration abnormal ": 4.333224447277258, "Respiratory acidosis ": 12.832259779831972, "Respiratory arrest ": 12.274701265957283, "Respiratory depression ": 30.651226131331384, "Respiratory disorder ": 2.538912377895171, "Respiratory distress ": 4.208192137088547, "Respiratory failure ": 5.499267495460927, "Respiratory rate decreased ": 6.054903238358053, "Respiratory rate increased ": 6.413143645879517, "Respiratory symptom ": 6.9683458417701365, "Restlessness ": 2.086160344776439, "Resuscitation ": 10.407503097962907, "Rhabdomyolysis ": 3.750315903647772, "Salivary hypersecretion ": 2.9668558410389174, "Schizencephaly ": 345.17629877803074, "Sedation ": 7.712113909653155, "Sedation complication ": 31.106211474758755, "Seizure ": 2.646600842335089, "Seizure like phenomena ": 24.69596755079265, "Serotonin syndrome ": 2.819100199761688, "Sinus tachycardia ": 6.824046963811249, "Somnolence ": 2.119742858544856, "Status epilepticus ": 15.10022263587256, "Stillbirth ": 8.019766682692266, "Stress cardiomyopathy ": 11.479068475452708, "Stupor ": 3.630988388418596, "Substance abuse ": 2.8201015187194085, "Sudden death ": 2.672468995177815, "Tachycardia ": 3.3846395221081487, "Tachyphylaxis ": 62.39276566404961, "Tachypnoea ": 2.6249652405781188, "Therapeutic response decreased ": 2.3633189408760296, "Therapy change ": 11.153434315403125, "Tonic convulsion ": 6.42482942222802, "Torsade de pointes ": 6.301394946101258, "Toxicity to various agents ": 4.682827189843585, "Tricuspid valve disease ": 56.46123559393571, "Type I hypersensitivity ": 7.4184987359905294, "Unresponsive to stimuli ": 9.047745310812244, "Unwanted awareness during anaesthesia ": 112.9254495135968, "Urinary tract candidiasis ": 108.9697483895517, "Ventricular extrasystoles ": 4.772773538230685, "Ventricular fibrillation ": 5.5421267164729375, "Ventricular tachycardia ": 3.272706574472644, "Withdrawal syndrome ": 4.036457781618344, "Wrong patient received product ": 7.322811070309023} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/721.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/721.json new file mode 100644 index 00000000000..8da6b6b87eb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/721.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 31.715570770834983, "Acute myeloid leukaemia recurrent ": 193.72812723359, "Ascites ": 12.16445840759628, "Drug interaction ": 2.5009466553780597, "Electrocardiogram QT prolonged ": 12.564313883995508, "Febrile neutropenia ": 16.53198203611618, "Malignant neoplasm progression ": 6.537038938722183, "Neutropenia ": 2.795933988644413, "Sepsis ": 6.140103921427586, "Septic shock ": 10.536515340003334, "Thrombocytopenia ": 4.082471137701314} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/722.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/722.json new file mode 100644 index 00000000000..05bd6d913c0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/722.json @@ -0,0 +1 @@ +{"Hypersensitivity myocarditis ": 56617.2757639899} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/723.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/723.json new file mode 100644 index 00000000000..ecfe2f350e2 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/723.json @@ -0,0 +1 @@ +{"Abdominal pain upper ": 2.0797347128692896, "Adenoma benign ": 142.36102134351103, "Angiopathy ": 10.238481164956204, "Blood calcium abnormal ": 155.49474724300757, "Blood calcium decreased ": 39.458404272688206, "Blood calcium increased ": 74.11910324376421, "Blood parathyroid hormone abnormal ": 853.2897477860769, "Blood parathyroid hormone decreased ": 68.61286924326238, "Blood parathyroid hormone increased ": 881.6131772894765, "Blood phosphorus decreased ": 22.28517840000421, "Blood phosphorus increased ": 26.900931614474924, "Bone pain ": 3.456732685835604, "Brown tumour ": 2998.3560143191157, "Calciphylaxis ": 153.1362978240474, "Cardiac failure ": 4.138387041176018, "Dementia ": 3.6802490962045935, "Dialysis ": 8.007333561418653, "Drug intolerance ": 13.614901194244338, "Dysphagia ": 10.24079618002619, "Electrocardiogram QT prolonged ": 2.017175315794044, "Eosinophilia ": 2.0786496488732835, "Epilepsy ": 2.533047565713162, "Erectile dysfunction ": 3.4881885459392232, "Gait inability ": 3.216013705819196, "Gastric haemorrhage ": 5.117987947110145, "Gastrointestinal disorder ": 9.903060537196342, "Gastrointestinal tube insertion ": 167.58058502170368, "Gastrostomy ": 155.17940999063666, "General physical health deterioration ": 2.3062790571342644, "Hospitalisation ": 3.356559704483112, "Hungry bone syndrome ": 1741.8962004735863, "Hypercalcaemia ": 58.74948521661065, "Hyperkalaemia ": 2.333956010667844, "Hyperparathyroidism ": 27.879968664447784, "Hyperphosphataemia ": 21.13003939953836, "Hypertensive crisis ": 4.509104610279337, "Hypocalcaemia ": 164.03636205488937, "Hypophosphataemia ": 11.28326852222456, "Malnutrition ": 6.854318975706754, "Muscle spasms ": 2.4120189069019107, "Nausea ": 2.131888829471804, "Nephrocalcinosis ": 80.32732908656111, "Nephrolithiasis ": 2.402138534431345, "Off label use ": 2.488066485273714, "Parathyroid disorder ": 147.73537481203763, "Parathyroid tumour benign ": 487.32319843541393, "Parathyroid tumour malignant ": 819.8834597316322, "Parathyroidectomy ": 988.230776727609, "Premature delivery ": 5.409134156361651, "Purpura ": 3.4626281311087963, "Rash pruritic ": 3.789961535698939, "Renal transplant ": 47.82512990416674, "Skin ulcer ": 4.911313439209337, "Surgery ": 2.374930569350868, "Tetany ": 45.6760341801204, "Therapeutic product effect incomplete ": 2.550045975516255, "Therapy non-responder ": 5.927293972471666, "Transaminases increased ": 3.1103871488772743, "Transplant ": 44.51280032992484, "Treatment noncompliance ": 5.726543965145249, "Underdose ": 11.165910865547437, "Unevaluable event ": 4.113144049503172, "Vomiting ": 2.29419501350584, "Wrong technique in product usage process ": 6.851611353012378} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/724.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/724.json new file mode 100644 index 00000000000..3845ca6dc5b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/724.json @@ -0,0 +1 @@ +{"Altered state of consciousness ": 5.39633365741133, "Atrial fibrillation ": 2.1080446807391726, "Blood pressure increased ": 6.980449298273246, "Constipation ": 3.633571707781436, "Drug interaction ": 2.963879047645045, "Dry mouth ": 4.327617987246495, "Dysuria ": 12.844730137379438, "Hyperammonaemia ": 30.185213718404963, "Hypercholesterolaemia ": 17.775597585053816, "Hypertension ": 7.971688112915015, "Implant site extravasation ": 367.6303099999968, "Incorrect route of product administration ": 8.5014818066818, "Intentional product misuse ": 3.649053886918591, "Lumbar vertebral fracture ": 66.75008605453684, "Muscle spasms ": 2.885954298210821, "Muscle spasticity ": 25.37170189770751, "Narcolepsy ": 112.2460116099052, "Neuropathy peripheral ": 2.9702303373441934, "Osteoporosis ": 2.106147722018445, "Palpitations ": 4.400537275479096, "Plicated tongue ": 426.50703372673775, "Pollakiuria ": 8.62787136213413, "Radial nerve injury ": 1483.774764809838, "Rectal prolapse ": 320.3578260631208, "Restless legs syndrome ": 13.378735557660166, "Rosacea ": 69.51356078794029, "Rotator cuff syndrome ": 25.548840965612587, "Spinal compression fracture ": 29.39997681632112, "Tachycardia ": 4.262459170990752, "Ulnar nerve injury ": 918.679257440768, "Urinary retention ": 24.650958829031502, "Urinary tract infection ": 7.128593923958391, "Urinary tract infection bacterial ": 113.56636034178511, "Vitamin B6 deficiency ": 1151.6607132013544} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/725.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/725.json new file mode 100644 index 00000000000..717bdc07737 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/725.json @@ -0,0 +1 @@ +{"Somnolence ": 6.10735563055617} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/726.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/726.json new file mode 100644 index 00000000000..ba838e43c37 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/726.json @@ -0,0 +1 @@ +{"Agonal respiration ": 378.5960489497312, "Anaemia ": 7.753643759986471, "Anaphylactic reaction ": 3.3934955734555463, "Anaphylactic shock ": 2.231083079273147, "Aplasia pure red cell ": 245.8315059291889, "Blood pressure decreased ": 4.631393462296765, "Blood pressure increased ": 3.4570393743604626, "Cardiac arrest ": 4.069832332566697, "Cardiac failure ": 4.08373523027156, "Cardio-respiratory arrest ": 3.235657699172516, "Cerebral haemorrhage ": 2.6203625704273983, "Cyanosis ": 2.059716480990238, "Death ": 7.532993355746476, "Drug hypersensitivity ": 63.10504240921421, "Drug ineffective ": 2.504344501157931, "Dyspnoea ": 2.788606025795872, "Feeling hot ": 3.396729513191999, "Flushing ": 12.91511937072492, "Fracture ": 2.00521205189836, "Gastrointestinal haemorrhage ": 2.045537022447713, "Haematocrit decreased ": 9.02569323503856, "Haemoglobin decreased ": 27.150315208530746, "Haemoglobin increased ": 35.968062055525465, "Hypersensitivity ": 2.0380517525422133, "Hypotension ": 2.242663784654157, "Iron deficiency anaemia ": 7.847782481175907, "Loss of consciousness ": 2.6975211508941954, "Marasmus ": 233.95195806552343, "Myelodysplastic syndrome ": 12.569013326754238, "Myelodysplastic syndrome with single lineage dysplasia ": 77.4415955149014, "No adverse event ": 16.87373296956922, "Pulmonary oedema ": 2.24889442074537, "Pulse absent ": 44.575794100875946, "Respiratory arrest ": 2.2219640631112245, "Respiratory distress ": 3.6647258506608034, "Reticulocyte count decreased ": 169.81047159311254, "Septic shock ": 2.2379664197970053, "Serum ferritin increased ": 12.76199881401562, "Shock ": 2.314983719551967, "Stevens-Johnson syndrome ": 2.059709091711614, "Therapeutic response decreased ": 5.085444742010496, "Therapy non-responder ": 4.787904904196162, "Throat tightness ": 5.015735851215882, "Unresponsive to stimuli ": 36.19180842117902} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/727.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/727.json new file mode 100644 index 00000000000..249be03d281 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/727.json @@ -0,0 +1 @@ +{"Application site erythema ": 73.8955897172656, "Application site pain ": 11.539053877987769, "Condition aggravated ": 10.170270220550512, "Dermatitis ": 22.39980999291057, "Dermatitis contact ": 68.41485373281414, "Erythema ": 27.253860281990885, "Feeling hot ": 9.760374108496348, "Flushing ": 31.52152054501875, "Hypersensitivity ": 3.3112914639899858, "Rebound effect ": 236.9391005386156, "Rosacea ": 711.5949721018367, "Skin burning sensation ": 105.16860408228771} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/728.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/728.json new file mode 100644 index 00000000000..ff1f9691e2a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/728.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 3.078737307373143, "Abdominal pain upper ": 2.303762379264908, "Abortion induced incomplete ": 376.5301586356688, "Alopecia ": 2.832206746671133, "Aphasia ": 20.773318408665148, "Atrial thrombosis ": 220.9642656207368, "Blister ": 5.008849940659971, "Dyskinesia ": 21.520422080572413, "Exposure during pregnancy ": 3.7550259546928393, "Inappropriate schedule of product administration ": 7.772847748160262, "Induced abortion failed ": 44.36925233704665, "Maternal exposure during pregnancy ": 9.446188138221132, "Metabolic acidosis ": 12.174774813714428, "Muscular weakness ": 6.466238838833422, "Off label use ": 2.791274438059856, "Paraesthesia oral ": 19.61731223106112, "Postpartum haemorrhage ": 274.6963063577937, "Product use in unapproved indication ": 2.3332521360094978, "Pulmonary thrombosis ": 50.67295901262548, "Small for dates baby ": 279.07197100062405, "Surgery ": 40.02432412518667, "Thrombosis ": 6.276124838980427, "Uterine rupture ": 1028.3502611416975, "Vaginal haemorrhage ": 25.645141802749496} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/729.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/729.json new file mode 100644 index 00000000000..0c526bae131 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/729.json @@ -0,0 +1 @@ +{"Adrenal insufficiency ": 143.74734735871854, "Central hypothyroidism ": 1979.9628794670311, "Disease progression ": 7.289522860348299, "Hypothyroidism ": 12.78136320557146, "Malignant neoplasm progression ": 16.095815953969478, "Mineralocorticoid deficiency ": 28927.234211841896, "Off label use ": 14.430669970603438, "Product use in unapproved indication ": 5.6574886459979} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/73.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/73.json new file mode 100644 index 00000000000..194dace53e3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/73.json @@ -0,0 +1 @@ +{"Abscess ": 3.4088407597988524, "Adrenal insufficiency ": 10.160710950054884, "Alpha tumour necrosis factor increased ": 903.530592265182, "Alveolar proteinosis ": 135.4513938645052, "Ankle arthroplasty ": 115.11539136959284, "Ankylosing spondylitis ": 2.260988298120851, "Anti-cyclic citrullinated peptide antibody positive ": 5.267850886950919, "Anti-neutrophil cytoplasmic antibody positive vasculitis ": 10.334892715896435, "Antibody test positive ": 51.39037263212762, "Apparent death ": 699.1225933891851, "Arthritis ": 2.9993302429471487, "Arthrodesis ": 214.09990399409415, "Arthropathy ": 13.007647934214392, "Aspartate aminotransferase ": 100.15806602655712, "Autoinflammatory disease ": 238.03094422202145, "Axial spondyloarthritis ": 173.9816138466296, "Back disorder ": 2.0634008955343472, "Barotrauma ": 647.1328900046018, "Basal cell carcinoma ": 3.061743127016584, "Blister rupture ": 32.52902958506136, "Blood glucose fluctuation ": 2.1190273500288237, "Blood immunoglobulin A increased ": 66.24806939675368, "Blood pressure diastolic decreased ": 8.832667405605523, "Blood pressure fluctuation ": 5.194217442138185, "Blood pressure systolic abnormal ": 14.513795267847357, "Blood pressure systolic decreased ": 6.417537827206794, "Blood test abnormal ": 3.0208704222921985, "Blood uric acid increased ": 3.7484852172391294, "Body height below normal ": 281.1872421712064, "Body tinea ": 165.77864200420166, "Bone density abnormal ": 3.302796236996701, "Bone density increased ": 86.04486263980219, "Bone erosion ": 4.033779177202423, "Bone marrow failure ": 2.450338327596717, "C-reactive protein abnormal ": 30.275370316116856, "C-reactive protein increased ": 11.551156548490807, "Cataract ": 2.676169655529511, "Cholecystitis acute ": 8.412853877057474, "Chondrocalcinosis ": 86.67267192740884, "Clear cell renal cell carcinoma ": 17.51310980137076, "Clubbing ": 169.47928810488636, "Coeliac disease ": 2.747239050458302, "Complications of bone marrow transplant ": 91.57334779058392, "Condition aggravated ": 2.6571572716387206, "Contraindicated product administered ": 21.662319919061044, "Coordination abnormal ": 2.3930557784256137, "Cytokine release syndrome ": 4.4683023572488585, "Deep vein thrombosis ": 6.951022350424736, "Deformity ": 94.89663659365397, "Diverticulitis ": 30.81329001782712, "Drug hypersensitivity ": 11.26621782250936, "Drug ineffective ": 5.274345155357734, "Drug intolerance ": 10.596363906232725, "Drug specific antibody ": 41.92979281788055, "Drug specific antibody present ": 33.578332789708206, "Drug use disorder ": 4.46261842793169, "Endodontic procedure ": 56.488394481051664, "Febrile infection-related epilepsy syndrome ": 512.0796695649108, "Feeling abnormal ": 2.216047695579872, "Fine motor skill dysfunction ": 8.751303192217922, "Finger deformity ": 5.857649107687596, "Foot deformity ": 16.127376329404633, "Foot operation ": 16.853684220720293, "Gastroenteritis viral ": 2.91403498341792, "Gastrointestinal perforation ": 13.037557209225357, "Glucose tolerance impaired ": 22.199137176182617, "Grip strength decreased ": 4.428822769221017, "Haemodynamic instability ": 3.1532712800465563, "Haemoglobin decreased ": 2.951978272253908, "Haemophagocytic lymphohistiocytosis ": 17.560226980134424, "Hair follicle tumour benign ": 239.867692138681, "Hand deformity ": 6.272781466344495, "Heart rate decreased ": 2.213430083068383, "Hepatosplenic T-cell lymphoma ": 129.96523550269524, "Hepatosplenomegaly ": 6.098629660157629, "Hepatotoxicity ": 21.505856923663856, "Herpes zoster ": 2.848264339664613, "Human antichimeric antibody positive ": 327.4727936270185, "Hyperlipidaemia ": 2.091261301758052, "Hyperparathyroidism secondary ": 59.985525982592, "Hypomagnesaemia ": 6.48349124968415, "Ill-defined disorder ": 20.73302986042013, "Impaired healing ": 2.705227249070439, "Impaired quality of life ": 13.052524413582692, "Impaired work ability ": 4.63505431041742, "Infection ": 3.525540576911925, "Infection susceptibility increased ": 6.093063323525795, "Inhibitory drug interaction ": 10.521451883489991, "Injection site hypersensitivity ": 6.726597611740453, "Injection site reaction ": 2.663315037963486, "Intentional product use issue ": 9.21850463348562, "Interleukin level increased ": 106.50186381140963, "Interstitial lung disease ": 5.930703949589351, "Intestinal sepsis ": 1036.883909789384, "Jaw fracture ": 9.31713815930538, "Joint arthroplasty ": 185.2704447919268, "Joint destruction ": 14.494195701865946, "Joint effusion ": 5.571539098105633, "Joint injury ": 10.07924266986508, "Joint range of motion decreased ": 2.9220206063504315, "Joint swelling ": 13.605380101333427, "Juvenile idiopathic arthritis ": 70.2697565729198, "Knee arthroplasty ": 27.68503273740249, "Localised infection ": 4.99459380194368, "Loss of consciousness ": 4.989524303724422, "Lymphoproliferative disorder ": 9.834574828168238, "Magnetic resonance imaging head abnormal ": 10.20912020746489, "Mobility decreased ": 17.891113336828145, "Monocyte chemotactic protein-1 increased ": 4518.732904412501, "Multiple-drug resistance ": 11.218753785241592, "Musculoskeletal disorder ": 47.896622089975885, "Musculoskeletal pain ": 16.16478557257648, "Myocardial infarction ": 2.451164047016015, "Neck pain ": 6.03337410997935, "New onset refractory status epilepticus ": 104.17914485032036, "No adverse event ": 9.29073798697564, "Nodule ": 21.314026062593165, "Obesity ": 7.672484533025304, "Off label use ": 3.588936772623088, "Pain ": 3.0632426423754064, "Photosensitivity reaction ": 13.697778504350682, "Pleural adhesion ": 88.2559498903586, "Pneumonia lipoid ": 108.9085412381968, "Polyarteritis nodosa ": 39.2025044059492, "Polyarthritis ": 12.56571645821245, "Poor quality sleep ": 8.115974618438939, "Post procedural contusion ": 149.62107970785385, "Prescribed underdose ": 16.092328740094636, "Psoriasis ": 2.0365221602968604, "Pulmonary embolism ": 5.026160884739034, "Pulmonary fibrosis ": 8.087008746306887, "Pulmonary thrombosis ": 56.50407474955294, "Quality of life decreased ": 9.834294971345996, "Red blood cell sedimentation rate abnormal ": 162.28748150609337, "Red blood cell sedimentation rate decreased ": 73.31830171228482, "Red blood cell sedimentation rate increased ": 57.61749784620742, "Renal failure ": 2.5998176343247703, "Rheumatoid arthritis ": 14.97446116101984, "Rheumatoid factor positive ": 19.394685961484104, "Sacroiliitis ": 41.80354409344876, "Sciatica ": 2.452075853294096, "Sepsis ": 4.690349100202264, "Septic shock ": 3.497504590144707, "Serum ferritin increased ": 9.350318386341488, "Shoulder arthroplasty ": 115.23191269231651, "Skin fissures ": 8.410424845715989, "Smear cervix abnormal ": 72.09996219437022, "Spinal stenosis ": 2.73631308061473, "Splenomegaly ": 3.927239345850542, "Spondyloarthropathy ": 116.03042657379598, "Stent placement ": 13.54151920680213, "Still's disease ": 38.56846597662207, "Stomatitis ": 3.225649236251964, "Syncope ": 2.257386136910581, "Synovial cyst ": 8.61115687772726, "Synovitis ": 13.943260613063604, "T-cell lymphoma ": 28.901442041962586, "Terminal state ": 76.00822313181803, "Therapeutic product effect decreased ": 16.240962556610636, "Therapeutic product effect incomplete ": 10.216341338857733, "Therapy non-responder ": 3.1689852155767, "Thrombosis ": 3.936072121391616, "Tooth disorder ": 4.6749299971638365, "Toothache ": 3.795449975751888, "Treatment failure ": 12.741733092693355, "Type IV hypersensitivity reaction ": 14.933718151158471, "Ulcer ": 5.846560033257857, "Vitamin D decreased ": 17.13515439897042, "Wheelchair user ": 7.153326826585732} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/730.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/730.json new file mode 100644 index 00000000000..e4eebe5fe37 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/730.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 4.915194563394945, "Anaphylactic shock ": 2.9126298870710503, "Angina pectoris ": 3.6450654210813416, "Blood glucose abnormal ": 21.036016878035117, "Blood glucose decreased ": 7.097214063538854, "Blood glucose fluctuation ": 19.7366608186142, "Blood glucose increased ": 21.191317283004476, "Coma ": 3.123999946806339, "Device failure ": 29.74375471385549, "Diabetes mellitus inadequate control ": 24.90666304953643, "Diabetic coma ": 46.458681894083526, "Diabetic foot ": 85.83869103505633, "Diabetic ketoacidosis ": 27.385474127679416, "Gangrene ": 31.619309296179427, "Glycosylated haemoglobin increased ": 6.568116180033895, "Hyperglycaemia ": 57.06103805491388, "Hypersensitivity ": 4.453007068751582, "Hypoglycaemia ": 34.55391722451432, "Hypoglycaemic coma ": 117.8720885637614, "Injection site abscess ": 68.76364098067428, "Injection site reaction ": 5.044178056233551, "Liquid product physical issue ": 46.19583586412519, "Maternal exposure during pregnancy ": 3.0016215913852964, "Overdose ": 2.180112163946692, "Pallor ": 3.961992413953552, "Product quality issue ": 7.925849101663631, "Product storage error ": 8.659812233775915, "Treatment noncompliance ": 5.101551800741766, "Wrong technique in product usage process ": 4.966540947246091} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/731.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/731.json new file mode 100644 index 00000000000..84102e88e8f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/731.json @@ -0,0 +1 @@ +{"Abnormal faeces ": 2.2191072859617997, "Acute disseminated encephalomyelitis ": 4.90569215227574, "Administration site erythema ": 3.4670877470531285, "Allergy to metals ": 126.83694354529229, "Antibody test negative ": 20.75810856637325, "Apathy ": 2.9328853250945754, "Aphthous ulcer ": 2.1865439005874423, "Apnoea ": 4.161526218099412, "Application site urticaria ": 8.755671041850686, "Ataxia ": 2.0973131117675377, "Autism spectrum disorder ": 7.923270583640497, "Body temperature decreased ": 6.548659433986612, "Body temperature increased ": 3.589282046461688, "Breath holding ": 51.02515718285372, "Catarrh ": 18.710368379659894, "Conjunctival hyperaemia ": 2.807183475292194, "Conjunctivitis ": 18.754667283918312, "Cough ": 3.60011221592302, "Crying ": 49.19719809230512, "Cyanosis ": 3.855174341627112, "Cyanosis central ": 24.479392325066605, "Decreased appetite ": 3.180327101272641, "Delirium febrile ": 29.912972887841025, "Dermatitis atopic ": 4.177515936600098, "Drooling ": 6.935784455908836, "Ear infection ": 7.379085670287184, "Ear swelling ": 2.030182087393097, "Ecchymosis ": 2.269324918225508, "Eczema ": 3.418287827688867, "Enanthema ": 6.144632904899591, "Encephalitis ": 2.413283661116198, "Erythema of eyelid ": 2.844969311147835, "Exanthema subitum ": 44.1801676623634, "Exposure via skin contact ": 5.141620923760652, "Extensive swelling of vaccinated limb ": 2.941809985853985, "Eye discharge ": 2.7405085538727927, "Eye inflammation ": 5.861368482614195, "Eye movement disorder ": 3.96700055365045, "Febrile convulsion ": 61.82734470855022, "Gastroenteritis ": 2.365124807172967, "Gaze palsy ": 15.768668091530634, "Gianotti-Crosti syndrome ": 53.6910382152705, "Head banging ": 14.447342841230578, "Henoch-Schonlein purpura ": 4.151781861430987, "Hyperaemia ": 2.5340654820322897, "Hyperpyrexia ": 61.9294216501321, "Hypertonia ": 7.869019385311396, "Hyporesponsive to stimuli ": 4.631635040947092, "Hypotonia ": 4.534406081600937, "Hypotonic-hyporesponsive episode ": 36.14993408742078, "Immune thrombocytopenia ": 6.732366864583718, "Infantile back arching ": 73.2441974743109, "Infection susceptibility increased ": 2.883652658598969, "Injected limb mobility decreased ": 2.752424731916186, "Injection site discomfort ": 2.01908748162016, "Injection site erythema ": 7.60287510516651, "Injection site inflammation ": 4.126982063857407, "Injection site oedema ": 2.453367024156379, "Injection site rash ": 4.624084386621269, "Injection site swelling ": 2.586641463528682, "Injection site vesicles ": 11.23907686264527, "Injection site warmth ": 2.2419999128532435, "Irritability ": 4.687593131372768, "Irritability postvaccinal ": 593.8582125548261, "Juvenile idiopathic arthritis ": 3.620966937599512, "Laryngitis ": 3.3423246520516656, "Listless ": 78.48819994934202, "Local reaction ": 2.94402812755673, "Lymphadenitis ": 3.674532324759927, "Lymphadenopathy ": 2.980412633495709, "Maternal exposure before pregnancy ": 11.285844510184155, "Measles ": 43.75512412166614, "Measles antibody negative ": 138.13164024857514, "Measles post vaccine ": 137.43701108319576, "Meningism ": 3.955422373628032, "Moaning ": 7.823572444570948, "Mumps ": 21.46837729829788, "Mumps antibody test negative ": 100.51277911411076, "Nasopharyngitis ": 9.713547105587658, "No adverse event ": 2.656756481863554, "Noninfective sialoadenitis ": 14.41155945541538, "Oligodipsia ": 70.21447117876387, "Opisthotonus ": 4.972029947016519, "Oral mucosal eruption ": 5.925652820205065, "Orchitis ": 9.51702650626466, "Otitis media ": 14.109401929844422, "Otitis media acute ": 19.158406091721755, "Pallor ": 5.93730885954629, "Papule ": 2.9653925426285235, "Parotid gland enlargement ": 82.10370106574, "Parotitis ": 34.78395360307713, "Petechiae ": 5.56932217385685, "Pharyngeal erythema ": 19.45851738799934, "Pharyngitis ": 8.14258624957039, "Poor quality sleep ": 2.941150128798684, "Postictal state ": 4.896427972657276, "Pyrexia ": 6.767609389863074, "Rash ": 4.779050063164862, "Rash erythematous ": 4.232976187507645, "Rash macular ": 17.88957498348627, "Rash maculo-papular ": 4.380605918029413, "Rash morbilliform ": 223.28548270895348, "Rash papular ": 12.78169540931529, "Rash pruritic ": 2.410353082935357, "Rash rubelliform ": 506.8084816369881, "Rash vesicular ": 26.97762269354571, "Reaction to excipient ": 26.152224523580703, "Respiration abnormal ": 4.477757732942134, "Respiratory tract infection ": 2.498024128645964, "Restlessness ": 4.237835274856017, "Rhinitis ": 5.836410905507463, "Rhinorrhoea ": 2.561623267502285, "Rubella ": 40.41853472716425, "Rubella antibody negative ": 90.74842407454018, "Salivary gland enlargement ": 4.84422517230094, "Salivary gland pain ": 12.110602093909923, "Scratch ": 28.134086092751165, "Screaming ": 61.73822130358348, "Skin warm ": 3.535789791234909, "Skin wound ": 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3.3889141175212, "Vaccination site granuloma ": 308.6592987071166, "Vaccination site hypertrichosis ": 300.3033382253412, "Vaccination site hypertrophy ": 179.99183316614966, "Vaccination site irritation ": 37.3490613321216, "Vaccination site nodule ": 19.86285678898617, "Vaccination site oedema ": 6.734524941574374, "Vaccination site pruritus ": 6.016484327402222, "Vaccination site rash ": 6.036000036173157, "Vaccination site reaction ": 4.148795048017177, "Vaccination site scar ": 34.217966005721514, "Vaccination site swelling ": 5.4202125544230855, "Vaccination site urticaria ": 3.3470804440743254, "Vaccination site vesicles ": 87.9787336902428, "Viral infection ": 2.170415844695514, "Vomiting ": 2.3333715961180763, "Vomiting projectile ": 3.1169022698731026} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/732.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/732.json new file mode 100644 index 00000000000..3b04915a7eb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/732.json @@ -0,0 +1 @@ +{"Blood glucose increased ": 7.70676283649294, "Constipation ": 5.630627601128025, "Decreased appetite ": 3.348974610353619, "Hypoglycaemia ": 10.871861929520716, "Pancreatitis ": 12.105980806309844} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/733.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/733.json new file mode 100644 index 00000000000..dbe7066a9be --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/733.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.8812252249388832, "Abdominal pain upper ": 2.458505551882922, "Accidental overdose ": 10.739194637913451, "Accidental underdose ": 331.37723142486703, "Asthenia ": 2.0222717689019443, "Back pain ": 4.878319875407518, "Blood pressure increased ": 2.014197915241601, "Bone 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100644 index 00000000000..64442494cb1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/734.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 5.140314491514364, "Acute pulmonary oedema ": 4.294321954024987, "Alanine aminotransferase increased ": 7.750640114159855, "Arrhythmia ": 5.199257544728525, "Aspartate aminotransferase increased ": 7.897331596603005, "Atrial fibrillation ": 42.74937789232369, "Atrial flutter ": 27.74035632452737, "Blood alkaline phosphatase increased ": 7.366273034055711, "Blood bilirubin increased ": 6.128848835164764, "Blood creatinine increased ": 10.203298766751136, "Blood potassium increased ": 2.5343356117869105, "Blood thyroid stimulating hormone increased ": 4.8979461643180615, "Blood urea increased ": 3.67620570405038, "Bradycardia ": 5.644514539408192, "Brain natriuretic peptide increased ": 17.529504878493565, "Cardiac arrest ": 2.258779567346792, "Cardiac failure ": 10.699500476481788, "Cardiac failure chronic ": 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6.985750944358415, "Hepatic enzyme increased ": 4.548486744941788, "Hepatic failure ": 5.437816619526552, "Hepatitis ": 3.08676594123693, "Hepatitis acute ": 3.964794264298266, "Hepatitis toxic ": 6.139875882219048, "Hepatocellular injury ": 59.08653909835128, "Hepatotoxicity ": 2.2396029478194133, "Hyperthyroidism ": 6.79952728465395, "Hypertransaminasaemia ": 2.3460573106831637, "International normalised ratio abnormal ": 8.62087862811712, "International normalised ratio decreased ": 4.887511920054617, "International normalised ratio increased ": 14.238108353615944, "Interstitial lung disease ": 2.251515553064867, "Jaundice ": 3.908589244910284, "Left ventricular failure ": 10.09203072065948, "Liver function test abnormal ": 5.79210362936562, "Liver function test increased ": 6.135229458683927, "Liver injury ": 3.457507176451214, "Long QT syndrome ": 11.484943071370012, "Lung disorder ": 2.1862765197534446, "Lung infiltration ": 5.005714737087952, "Mixed liver injury ": 10.017366773863175, "Oedema ": 3.054920461652236, "Oedema peripheral ": 4.365051480602233, "Papilloedema ": 4.683874972733009, "Pericardial effusion ": 2.284978435869312, "Photosensitivity reaction ": 6.33796335013457, "Pleural effusion ": 2.12957804766806, "Polyneuropathy ": 2.378831802044324, "Prothrombin time prolonged ": 2.7897714157547737, "Pulmonary congestion ": 3.612147838508995, "Pulmonary fibrosis ": 8.012815510561927, "Pulmonary oedema ": 3.857883659075641, "Pulmonary toxicity ": 8.409473394434361, "Sinus bradycardia ": 4.171222645077596, "Sudden cardiac death ": 8.523491933733446, "Sudden death ": 3.38538492458209, "Torsade de pointes ": 13.64594892288073, "Transaminases increased ": 10.02822063539033, "Underdose ": 9.33628254728198, "Ventricular extrasystoles ": 8.343785143255133, "Ventricular fibrillation ": 7.301459660059155, "Ventricular tachycardia ": 15.582914583588828, "Weight increased ": 3.217711318469331, "Wrong technique in product usage process ": 2.202025732545953} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/735.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/735.json new file mode 100644 index 00000000000..aaec224a869 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/735.json @@ -0,0 +1 @@ +{"Hypersensitivity ": 63.82604062080042, "Rash pruritic ": 198.8078758391397, "Urticaria ": 52.12986064766994} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/736.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/736.json new file mode 100644 index 00000000000..a1b6c994b6d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/736.json @@ -0,0 +1 @@ +{"Cardio-respiratory arrest ": 155.41552010783303, "Completed suicide ": 25.99729175529041, "Death ": 13.24132229025374, "Drug abuse ": 72.59094091393193, "Toxicity to various agents ": 31.393186735098087} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/737.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/737.json new file mode 100644 index 00000000000..1f3b7ca54f0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/737.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.376389242629678, "Bacterial endophthalmitis ": 3913.820333543581, "Constipation ": 3.786498101750929, "Disease progression ": 2.786520313663726, "Endophthalmitis ": 48.67939417933724, "Hypertension ": 2.232886592294536, "Intestinal obstruction ": 13.719040317628911, "Macular oedema ": 49.39423957211921, "Neuropathy peripheral ": 16.317162304897654, "Neutropenia ": 3.5918846442892827, "Off label use ": 5.058571844123431, "Ovarian cancer ": 41.772609923864295, "Pulmonary embolism ": 2.0226646515951123, "Rectal haemorrhage ": 4.942017048857083, "Thrombocytopenia ": 4.148706130123995} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/738.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/738.json new file mode 100644 index 00000000000..a061a287848 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/738.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 3.32319548744242, "Aspartate aminotransferase increased ": 3.064833133077701, "Blood bilirubin increased ": 7.456684090815462, "Candida infection ": 30.64944417198894, "Death ": 9.519610973294547, "Drug ineffective ": 2.665997422666876, "Fungal infection ": 12.813244983492597, "Haemolysis ": 38.06759928559801, "Haemolytic anaemia ": 18.52614058850419, "Hepatic cytolysis ": 10.635830280939317, "Hepatic enzyme increased ": 7.11490876436069, "Hepatic function abnormal ": 3.0241408115384925, "Intentional product misuse ": 3.040676915460081, "Jaundice ": 4.9417342443794565, "Multiple organ dysfunction syndrome ": 10.737063867899556, "Off label use ": 7.974546209364599, "Product use in unapproved indication ": 4.381018401171088, "Renal impairment ": 2.3924625668015924, "Respiratory failure ": 3.365906387549908, "Sepsis ": 6.16067849475906, "Thrombocytopenia ": 4.786201285534131, "Transaminases increased ": 9.10346476073404} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/739.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/739.json new file mode 100644 index 00000000000..128cbcc5612 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/739.json @@ -0,0 +1 @@ +{"Abscess ": 3.259838442479331, "Actinic keratosis ": 29.976872359533868, "Acute graft versus host disease ": 18.17143152520908, "Acute graft versus host disease in intestine ": 29.80960152005947, "Acute graft versus host disease in liver ": 58.69114474023494, "Acute graft versus host disease in skin ": 35.37857387935901, "Acute respiratory distress syndrome ": 2.926447753267604, "Adenocarcinoma ": 14.050966833140434, "Adenovirus infection ": 19.08039826910249, "Adjustment disorder with depressed mood ": 5.500815660546509, "Anti-erythropoietin antibody negative ": 62.32364709530312, "Aplasia pure red cell ": 9.399504414378557, "Aspergillus infection ": 22.9935490410116, "Atrial septal defect ": 2.9144085509852693, "Autoimmune disorder ": 4.464571586242477, "BK virus infection ": 64.16217618913932, "Bacteraemia ": 10.709392825571816, "Bacterial infection ": 4.753356925718961, "Bacterial sepsis ": 14.400579843309377, "Basal cell carcinoma ": 3.82562973979104, "Blood creatinine increased ": 3.06481573361942, "Blood pressure diastolic abnormal ": 16.133871072828164, "Bowen's disease ": 64.15577438979065, "Brain abscess ": 16.074020065500108, "Bronchopulmonary aspergillosis ": 26.929603193258327, "C-reactive protein ": 7.7084372572895585, "C-reactive protein abnormal ": 3.4257231173121463, "COVID-19 pneumonia ": 4.37840932876692, "Choroiditis ": 207.8826678735093, "Chronic allograft nephropathy ": 80.89388865194267, "Chronic graft versus host disease ": 25.5321948162184, "Chronic graft versus host disease in skin ": 30.61991320903457, "Clostridium difficile colitis ": 2.867416718776701, "Clostridium difficile infection ": 2.2562725367629133, "Complications of transplanted kidney ": 96.10346077841476, "Condition aggravated ": 2.071515572707461, "Congenital anomaly in offspring ": 118.30553058830397, "Cryptococcosis ": 49.16147166318974, "Cushingoid ": 9.505314501869144, "Cystitis haemorrhagic ": 9.580642855830051, "Cytomegalovirus chorioretinitis ": 10.453757484435751, "Cytomegalovirus colitis ": 49.00925824957943, "Cytomegalovirus infection ": 49.11547792337547, "Cytomegalovirus infection reactivation ": 45.46914466321498, "Cytomegalovirus oesophagitis ": 97.57945056011022, "Cytomegalovirus test positive ": 13.55302129206948, "Cytomegalovirus viraemia ": 67.58303911517848, "Deep vein thrombosis postoperative ": 13.623505003549036, "Delayed graft function ": 213.09868682027556, "Diffuse large B-cell lymphoma ": 6.305544363025444, "Disseminated tuberculosis ": 16.672248245333595, "Drug interaction ": 2.4756588071148644, "Drug level increased ": 3.01768961820426, "Drug resistance ": 3.0396911705658147, "Duodenal ulcer perforation ": 3.714255700967463, "Encephalitis ": 3.838708246930884, "Endophthalmitis ": 8.316813263237535, "Enterococcal infection ": 18.384731467801107, "Epstein-Barr virus infection ": 26.37805706020179, "Epstein-Barr virus infection reactivation ": 19.043328315297224, "Escherichia infection ": 19.504960946915293, "Febrile neutropenia ": 2.587618501224336, "Fibromyalgia ": 2.1538809714135656, "Foetal growth restriction ": 4.008145349538796, "Folliculitis ": 2.090261069093498, "Fungal infection ": 8.881537006431833, "Gingival hypertrophy ": 11.531704646710814, "Graft versus host disease ": 15.416641353226195, "Graft versus host disease in gastrointestinal tract ": 33.62392949366133, "Graft versus host disease in skin ": 35.86845437186013, "Haemolytic anaemia ": 2.3839014661997275, "Haemophagocytic lymphohistiocytosis ": 7.553402835945369, "Heart transplant rejection ": 378.3491857867693, "Helicobacter infection ": 2.1221157607758925, "Hepatitis C ": 4.713906280729081, "Hepatitis E ": 46.77960080420841, "Histoplasmosis disseminated ": 100.02330172977037, "Human herpesvirus 6 infection ": 36.96272924040714, "Hydronephrosis ": 4.2588562025797145, "Hypercholesterolaemia ": 2.7622384369120505, "Hypogammaglobulinaemia ": 7.769776719502889, "Immune reconstitution inflammatory syndrome ": 2.537333217450452, "Immunosuppressant drug level decreased ": 26.11632803558124, "Immunosuppressant drug level increased ": 43.54833528534023, "Immunosuppression ": 6.88959264136623, "Impaired healing ": 2.2702477276897004, "Infection ": 2.3863514447589824, "Infection reactivation ": 50.180485758671146, "Intraocular pressure increased ": 6.39314413551151, "Kaposi's sarcoma ": 29.32600102404875, "Kidney fibrosis ": 27.65951176374417, "Kidney transplant rejection ": 70.929800746366, "Klebsiella infection ": 33.60958885421392, "Leukopenia ": 4.675234305738132, "Liver transplant rejection ": 37.03336670706999, "Localised infection ": 3.712961503535044, "Low birth weight baby ": 2.8153908894174893, "Lung infiltration ": 4.099191160928856, "Lung transplant rejection ": 50.09454433237544, "Lymphopenia ": 4.9875458444564815, "Malignant melanoma ": 2.360610977139317, "Mucormycosis ": 37.814590684748616, "Multiple organ dysfunction syndrome ": 4.072562385233291, "Mycobacterium avium complex infection ": 13.936788747017497, "Mycobacterium chelonae infection ": 40.13034780871492, "Mycobacterium haemophilum infection ": 295.84022379430326, "Myopathy ": 5.382053437002213, "Necrotising fasciitis ": 14.529584344702911, "Nephrectomy ": 16.403682988713747, "Nephropathy toxic ": 6.677698022101296, "Nephrotic syndrome ": 7.424659521508784, "Neutropenia ": 2.6755121806952684, "Nocardiosis ": 70.4218378211067, "Off label use ": 2.8294566652528577, "Opportunistic infection ": 31.335685602671106, "Osteomyelitis ": 2.723360144273229, "Pancytopenia ": 3.3596866918737027, "Papule ": 3.662419762310765, "Parvovirus B19 infection ": 83.11189606042485, "Peritonitis ": 3.214422121006701, "Pneumocystis jirovecii pneumonia ": 13.072287889091877, "Pneumonia ": 2.2162808758006376, "Pneumonia bacterial ": 6.415445726270518, "Pneumonia cytomegaloviral ": 45.275112236602936, "Polyomavirus viraemia ": 50.36090592134553, "Polyomavirus-associated nephropathy ": 175.33610809555947, "Post transplant lymphoproliferative disorder ": 67.84965207266681, "Posterior reversible encephalopathy syndrome ": 5.638336859025644, "Premature baby ": 2.3976253249398645, "Product use in unapproved indication ": 3.8993595125328055, "Progressive multifocal leukoencephalopathy ": 7.6479679881112705, "Proteinuria ": 5.134486465657435, "Pseudomonas infection ": 23.508561960276364, "Pulmonary mass ": 3.2598455729153497, "Pulmonary mucormycosis ": 94.65333735805204, "Pulmonary tuberculosis ": 9.78638286146358, "Pyelonephritis ": 3.543776549256607, "Rales ": 3.842133121245576, "Renal impairment ": 3.0646947639008943, "Renal transplant failure ": 134.16107115004408, "Renal tubular atrophy ": 30.744578105931502, "Renal tubular necrosis ": 7.743604056053625, "Respiratory failure ": 2.507956722803508, "Scleroderma ": 11.16677317624642, "Sepsis ": 4.117192490163676, "Septic shock ": 7.377238464992605, "Skin infection ": 6.338628070887749, "Skin lesion ": 3.4356428215250565, "Skin mass ": 7.927424619355481, "Skin plaque ": 5.740953783497286, "Smooth muscle cell neoplasm ": 116.2992879854938, "Splenomegaly ": 2.2510055548893777, "Squamous cell carcinoma ": 5.615078138353351, "Squamous cell carcinoma of skin ": 32.02257602776981, "Staphylococcal bacteraemia ": 9.481240695555716, "Staphylococcal infection ": 5.953067724101575, "Strongyloidiasis ": 65.07194970070154, "Therapy non-responder ": 4.002827639848039, "Thrombotic microangiopathy ": 11.557000540945156, "Transplant dysfunction ": 21.831008426222034, "Transplant failure ": 28.338988784353685, "Transplant rejection ": 82.47219106475374, "Tuberculosis ": 4.083420163765368, "Tubulointerstitial nephritis ": 2.039295664317062, "Urinary tract infection ": 2.230571036014113, "Urosepsis ": 3.926918980393963, "Uveitis ": 5.969201817680083, "Varicella zoster virus infection ": 24.95384070104273, "Venoocclusive liver disease ": 6.544657757662441, "Viral haemorrhagic cystitis ": 86.586966690326, "Visual acuity reduced ": 3.874615816425727, "Wound infection ": 7.200708827071009} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/74.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/74.json new file mode 100644 index 00000000000..edf9eed75ac --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/74.json @@ -0,0 +1 @@ +{"Completed suicide ": 62.16154448832651} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/740.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/740.json new file mode 100644 index 00000000000..18586884414 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/740.json @@ -0,0 +1 @@ +{"Death ": 20.988130933449742} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/741.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/741.json new file mode 100644 index 00000000000..a7a7460f7f3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/741.json @@ -0,0 +1 @@ +{"Neutropenia ": 17.874909035868072, "Thrombocytopenia ": 11.619604536662752} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/742.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/742.json new file mode 100644 index 00000000000..1c59f18d4bf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/742.json @@ -0,0 +1 @@ +{"Acute respiratory failure ": 5.054972475146406, "Adenoidectomy ": 117.32806557153818, "Aortic valve incompetence ": 21.161389535196328, "Apnoea ": 8.688030289211124, "Atelectasis ": 3.986047322358089, "Bacteraemia ": 4.12489650054704, "Blindness ": 2.930696847597626, "Body temperature increased ": 5.537805575717448, "Bone marrow transplant ": 51.802174574825216, "Brain oedema ": 2.815338211238017, "Bronchitis ": 2.2190030684039117, "Bronchospasm ": 7.0777177538668345, "Cardiac arrest ": 3.0666939014187347, "Cardiac disorder ": 2.6926295172548267, "Cardiac failure ": 2.5466420777667587, 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/745.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/745.json new file mode 100644 index 00000000000..2bc0d645f54 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/745.json @@ -0,0 +1 @@ +{"Completed suicide ": 39.61870617487866} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/746.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/746.json new file mode 100644 index 00000000000..f9824e76f50 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/746.json @@ -0,0 +1 @@ +{"Blood calcium decreased ": 160.57237064988138, "Drug ineffective ": 3.1211574668081687, "Hypocalcaemia ": 270.811839485896, "Paraesthesia ": 2.9420328543551912} \ No newline at end of file diff --git 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/753.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/753.json new file mode 100644 index 00000000000..ee6572d604f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/753.json @@ -0,0 +1 @@ +{"Accidental exposure to product ": 5.244019986987424, "Acute febrile neutrophilic dermatosis ": 19.18093011000357, "Acute myeloid leukaemia ": 2.970203081668104, "Acute respiratory distress syndrome ": 6.764957474492991, "Adverse drug reaction ": 3.011316265978972, "Adverse event ": 2.3149816439248965, "Application site bruise ": 69.43368450228891, "Application site haemorrhage ": 147.94494347623447, "Application site pain ": 2.804927795048449, "Application site swelling ": 2.047586347678803, "Back pain ": 2.6227792385709163, "Blood test abnormal ": 2.6430905838124468, "Body temperature abnormal ": 3.370314982099754, "Bone marrow disorder ": 6.196827253205792, "Bone 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/754.json new file mode 100644 index 00000000000..42f854d4342 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/754.json @@ -0,0 +1 @@ +{"Balance disorder ": 5.218219641160419, "Confusional state ": 2.4794313637043484, "Delusion ": 27.76609363995252, "Drug interaction ": 2.808906238412724, "Dyskinesia ": 16.903616598255795, "Feeling abnormal ": 3.0965184283149387, "Hallucination ": 10.668591887877795, "Hallucination, visual ": 26.680345183922075, "Impulse-control disorder ": 196.8637368244121, "Muscle spasms ": 2.701126862665208, "Paraesthesia ": 3.0162274619266016, "Parkinson's disease ": 37.36175526731196, "Parkinsonism ": 49.79497931617493, "Restless legs syndrome ": 44.914537122909735, "Somnolence ": 3.7610233048737256, "Tremor ": 2.0256489370443838} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/755.json 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6.632189376763898, "Eye inflammation ": 19.05092008840178, "Eye injury ": 44.86974810301137, "Eye irritation ": 69.30522951896134, "Eye pain ": 17.243385244591956, "Eye pruritus ": 9.125705316705805, "Eye swelling ": 9.686785587428348, "Eyelid oedema ": 8.951055236548877, "Foreign body sensation in eyes ": 270.04463671168526, "Glaucoma ": 16.039538818856528, "Incorrect dose administered ": 7.133756729011886, "Incorrect product administration duration ": 26.282126748301376, "Intraocular pressure increased ": 78.22279537298262, "Iris atrophy ": 1279.1583091864472, "Keratitis ": 40.83127661989203, "Lacrimation increased ": 19.52864943822285, "Liquid product physical issue ": 251.35581652330288, "Macular oedema ": 78.65877849794477, "Medication error ": 18.067108264281742, "Musculoskeletal stiffness ": 2.323828710187012, "Ocular discomfort ": 19.42386459040564, "Ocular hyperaemia ": 36.290202634937856, "Off label use ": 3.1496315863932898, "Photophobia ": 7.93625528005635, "Poor quality 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No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/756.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/756.json new file mode 100644 index 00000000000..cb49cffc72b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/756.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 6.866572548616, "Anaemia ": 2.730300400399101, "Blood cholesterol increased ": 2.4965651509278355, "Blood lactic acid increased ": 13.854278052634928, "CD4 lymphocyte percentage decreased ": 2550.2278007409845, "CD4 lymphocytes decreased ": 60.09547117088065, "Caesarean section ": 31.671640644760345, "Cardiac failure ": 4.424284030530442, "Cardiac failure congestive ": 2.2601849228807915, "Congenital central nervous system anomaly ": 97.95426256205126, "Conjunctival hyperaemia ": 21.831025787312583, "Conjunctivitis ": 8.519764558896153, "Dehydration ": 2.9419843847535723, "Developmental delay ": 17.136368666454633, "Drug reaction with eosinophilia and systemic symptoms ": 9.589111702593245, "Drug resistance ": 6.520830090898225, "Drug-induced liver injury ": 2.3634384908254806, "Exposure during pregnancy ": 5.671149179341528, "Foetal distress syndrome ": 34.31511743597952, "Foetal exposure during pregnancy ": 12.142572455099492, "Hepatitis ": 7.86872550732801, "Hepatotoxicity ": 17.634299746053117, "Hypertriglyceridaemia ": 11.968615933076451, "Hypotension ": 3.59620508815415, "Jaundice ": 3.4900073648353533, "Lactic acidosis ": 3.561322697959865, "Large intestine infection ": 118.8266648491754, "Lipodystrophy acquired ": 30.515514340110848, "Liver function test abnormal ": 3.90455602302544, "Maternal exposure during pregnancy ": 6.852834294827379, "Pancreatitis ": 2.6717245412653083, "Pregnancy ": 24.456437645591368, "Rash ": 2.659059907965461, "Rash erythematous ": 2.9038120464215305, "Rash maculo-papular ": 6.593499741032102, "Skin exfoliation ": 13.705335866268175, "Stevens-Johnson syndrome ": 86.68310203512402, "Stillbirth ": 35.25322250807682, "Toxic epidermal necrolysis ": 42.56978628869768, "Virologic failure ": 46.82189593573251} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/757.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/757.json new file mode 100644 index 00000000000..3ef8b42aee4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/757.json @@ -0,0 +1 @@ +{"Abdominal abscess ": 3.4208625086148183, "Abdominal lymphadenopathy ": 14.390225556137, "Abnormal loss of weight ": 2.884630197055093, "Abscess limb ": 2.258015054011106, "Acute abdomen ": 3.1720363172057837, "Acute coronary syndrome ": 3.2599777359171687, "Acute hepatic failure ": 3.21338627833468, "Acute interstitial pneumonitis ": 10.778957736920356, "Acute myocardial infarction ": 3.304658781788562, "Alanine aminotransferase abnormal ": 4.338331987285797, "Alanine aminotransferase increased ": 4.30035839253584, "Albumin urine present ": 17.109712630113386, "Alopecia ": 3.1744523086886707, "Alpha 1 foetoprotein abnormal ": 70.07344786311162, "Alpha 1 foetoprotein increased ": 262.19548775766816, "Ammonia increased ": 12.103147509851594, "Amylase increased ": 11.204096282799698, "Anal abscess ": 3.717694595348619, "Anal fistula ": 3.8626713946848215, "Anal ulcer ": 4.795745054407323, "Aortic dissection ": 4.539225268954751, "Aphthous ulcer ": 2.2346349326458785, "Ascites ": 14.769718058471272, "Aspartate aminotransferase abnormal ": 8.290245484033543, "Aspartate aminotransferase increased ": 5.725847411890204, "Asterixis ": 5.940329626523916, "Basal ganglia haemorrhage ": 5.584904634608644, "Bile duct stone ": 3.1322955378131527, "Biliary obstruction ": 5.109036920593755, "Blister ": 4.592003870250461, "Blood albumin decreased ": 6.378044209935301, "Blood bilirubin abnormal ": 4.833402952007588, "Blood bilirubin increased ": 11.522375727930156, "Blood pressure increased ": 2.334930103542417, "Blood thyroid stimulating hormone increased ": 2.807108039778952, "Brain stem haemorrhage ": 8.327588874693083, "Brain stem infarction ": 3.117070165763841, "C-reactive protein increased ": 2.336644432733549, "Cachexia ": 4.799714315454355, "Cancer pain ": 10.26437768483618, "Cerebellar haemorrhage ": 4.653300268645264, "Cerebral haemorrhage ": 3.202158516878405, "Cerebral infarction ": 3.449978452833957, "Child-Pugh-Turcotte score increased ": 30.98701604734112, "Cholangiocarcinoma ": 4.56239475175476, "Cholangitis ": 10.43012482591973, "Cholecystitis ": 2.4764229365856085, "Cholecystitis acute ": 3.260053774123534, "Colitis ischaemic ": 2.6145519494873977, "Coma hepatic ": 24.850311588862976, "Coronary artery stenosis ": 2.170399361140439, "Death ": 2.503465724243908, "Decreased appetite ": 4.270074362743918, "Dermal cyst ": 4.526140502652323, "Dermatitis ": 3.474828196584517, "Dermatitis acneiform ": 2.313862545664453, "Dermatitis bullous ": 3.4760071191104784, "Dermatitis exfoliative ": 3.940516452845788, "Dermatitis psoriasiform ": 2.076956033137758, "Desmoid tumour ": 31.28700167329784, "Diarrhoea ": 4.365043504982423, "Disseminated intravascular coagulation ": 3.661003157919884, "Diverticular perforation ": 4.79876505324729, "Diverticulum intestinal haemorrhagic ": 2.33225968549136, "Drug eruption ": 3.1744324025329207, "Dry skin ": 4.386110742939916, "Duodenal ulcer haemorrhage ": 2.3628842627026434, "Dyslalia ": 2.755021144384417, "Dysphonia ": 6.287836771291168, "Eastern Cooperative Oncology Group performance status worsened ": 12.243618517336646, "Eating disorder ": 2.285514767836658, "Enanthema ": 6.288340282235854, "Encephalopathy ": 3.0541839438948237, "Enterocolitis ": 2.2230404333965, "Enterocolitis haemorrhagic ": 2.0096649774626254, "Epidermolysis ": 10.292004997085044, "Erythema multiforme ": 19.887232018501354, "Exfoliative rash ": 2.618476216275731, "Extremity necrosis ": 2.910304177394224, "Faeces discoloured ": 3.241241134641345, "Fistula ": 3.379818527178277, "Food refusal ": 8.308368799274705, "Furuncle ": 2.9628835777323466, "Gastric antral vascular ectasia ": 30.554153342376058, "Gastric haemorrhage ": 5.518878763099375, "Gastric ulcer ": 3.158396165668956, "Gastric ulcer haemorrhage ": 4.340003391782286, "Gastric varices haemorrhage ": 41.71983923940159, "Gastrointestinal haemorrhage ": 2.939306113624412, "Gastrointestinal perforation ": 10.247663107593302, "Gastrointestinal stromal tumour ": 2.679323249244824, "General physical health deterioration ": 3.0455009523359715, "Gingival bleeding ": 3.17010531532471, "Glossitis ": 2.618656485935144, "Haematemesis ": 4.566180596194154, "Haematochezia ": 2.065175509226473, "Haemobilia ": 55.40618228772155, "Haemoperitoneum ": 2.38478140710606, "Haemoptysis ": 5.931159267589055, "Haemothorax ": 4.453077289386711, "Hepatic cancer ": 26.53183321462419, "Hepatic cancer metastatic ": 22.59660865467791, "Hepatic cancer recurrent ": 23.004327011639884, "Hepatic cancer stage IV ": 21.91977100199012, "Hepatic cirrhosis ": 3.32044331466792, "Hepatic cyst ": 2.2306814444562675, "Hepatic encephalopathy ": 42.154087398225926, "Hepatic failure ": 11.48919229175478, "Hepatic function abnormal ": 8.49895943130735, "Hepatic infarction ": 30.31547483983686, "Hepatic lesion ": 14.791776052853082, "Hepatic mass ": 7.88935457435623, "Hepatic necrosis ": 2.176164379130741, "Hepatic neoplasm ": 4.138244583619787, "Hepatic rupture ": 77.29630421893182, "Hepatitis B reactivation ": 2.228811547482642, "Hepatitis acute ": 2.626900605097561, "Hepatitis fulminant ": 2.154395045709915, "Hepatocellular carcinoma ": 523.0707210796588, "Hepatorenal failure ": 6.587030998065674, "Hepatorenal syndrome ": 13.417094230003466, "Hiccups ": 3.107871733802602, "Hilar lymphadenopathy ": 8.536389729584071, "Hyperammonaemia ": 3.817834493446929, "Hyperamylasaemia ": 18.404690150414865, "Hyperbilirubinaemia ": 4.206334954951767, "Hyperkeratosis ": 23.754024647137253, "Hypertension ": 4.752470758247491, "Hypertransaminasaemia ": 2.3681407466998494, "Hyperuricaemia ": 2.3850677568379104, "Hypoalbuminaemia ": 4.714868488078781, "Hypocalcaemia ": 4.161016356003176, "Hypophosphataemia ": 9.03541799987023, "Hypoproteinaemia ": 3.3533500723636074, "Interstitial lung disease ": 2.0728150186380643, "Intestinal perforation ": 2.091346001228908, "Intra-abdominal haemorrhage ": 3.892114291958697, "Iron deficiency ": 2.1646648075155395, "Jaundice ": 5.969779730059007, "Jaundice cholestatic ": 6.9100771723361385, "Keratoacanthoma ": 25.238659201396885, "Lacunar infarction ": 3.2938767148953887, "Large intestinal haemorrhage ": 4.913895639642781, "Large intestine perforation ": 4.894418353014849, "Leukoencephalopathy ": 2.7692695604274853, "Lipase increased ": 5.687153491700794, "Liver abscess ": 10.125482308195616, "Liver carcinoma ruptured ": 297.61951492211045, "Liver disorder ": 4.91871587189219, "Liver function test increased ": 3.1704099325642408, "Lower gastrointestinal haemorrhage ": 4.407844073319892, "Lung abscess ": 3.4396696421049247, "Lung cancer metastatic ": 2.8190849298960323, "Lung neoplasm ": 3.069204360384449, "Lymphadenopathy mediastinal ": 10.950571625321064, "Lymphangiosis carcinomatosa ": 6.543280564162787, "Malignant ascites ": 9.704594799694252, "Malignant pleural effusion ": 7.209523246523186, "Melaena ": 5.33317546389968, "Mesenteric vein thrombosis ": 2.9009174589856137, "Metastases to abdominal cavity ": 25.96536125872216, "Metastases to adrenals ": 43.63209954533655, "Metastases to bone ": 9.928395767594251, "Metastases to central nervous system ": 4.810446488160231, "Metastases to heart ": 17.7977981189221, "Metastases to liver ": 3.053413220496524, "Metastases to lung ": 35.83003586033936, "Metastases to lymph nodes ": 11.363897750905126, "Metastases to peritoneum ": 11.751850587579357, "Metastases to pleura ": 9.428577915943851, "Metastases to spine ": 16.876739383629452, "Metastases to spleen ": 11.90556601257187, "Metastasis ": 6.630588623025816, "Metastatic renal cell carcinoma ": 8.197947416268333, "Mouth haemorrhage ": 3.678798995538519, "Mouth ulceration ": 2.2890906393397765, "Mucosal disorder ": 2.252510641610624, "Mucosal inflammation ": 4.406268651420727, "Myocardial ischaemia ": 2.83048811523868, "Nephrotic syndrome ": 7.691775605357985, "Ocular icterus ": 3.0906704393524307, "Oesophageal haemorrhage ": 5.47133373356446, "Oesophageal ulcer ": 3.5069615807318923, "Oesophageal varices haemorrhage ": 64.93929950231525, "Off label use ": 2.3037814594639823, "Oral mucosa erosion ": 6.173828220541467, "Oral pain ": 2.1853232110713425, "Osteitis ": 4.8747877273999, "Osteolysis ": 5.407297025091355, "Osteonecrosis of jaw ": 2.549461265328836, "Osteosarcoma ": 8.099751990899538, "Pain of skin ": 4.649006485479259, "Palmar erythema ": 8.540918636972627, "Palmar-plantar erythrodysaesthesia syndrome ": 119.08039126054707, "Palmoplantar keratoderma ": 44.17969983410938, "Pancreatic enzymes increased ": 16.551433861855426, "Pancreatitis acute ": 3.215301896133324, "Papillary thyroid cancer ": 9.220969723878095, "Performance status decreased ": 2.4707477031365843, "Peritonitis ": 2.4924478670896604, "Physical deconditioning ": 2.456040975280282, "Plantar erythema ": 38.92430833213189, "Platelet count decreased ": 5.221128355810861, "Pleurisy ": 2.0141032359866107, "Pneumatosis intestinalis ": 4.561519399465767, "Pneumoperitoneum ": 6.331969999942376, "Portal hypertension ": 2.409117571334489, "Portal vein thrombosis ": 10.14030283768059, "Protein induced by vitamin K absence or antagonist II increased ": 369.74579649025935, "Protein urine present ": 2.79279986788058, "Proteinuria ": 4.354487559138087, "Pulmonary mass ": 2.852158342263045, "Pulmonary tuberculosis ": 2.0155529752909755, "Pustular psoriasis ": 2.572310224818957, "Pustule ": 2.446503208664056, "Rash ": 2.4454036030821573, "Rash maculo-papular ": 2.130480555193378, "Rash papular ": 2.0587197190261666, "Reactive perforating collagenosis ": 74.97237136613865, "Renal cancer ": 3.4458437632729155, "Renal cancer metastatic ": 4.367835073890012, "Renal cell carcinoma ": 27.15587457743393, "Retinal vein thrombosis ": 3.3760254092020348, "Retroperitoneal lymphadenopathy ": 22.06095574041033, "Scrotal erythema ": 49.05166207153078, "Secondary hypertension ": 12.399022293355722, "Skin erosion ": 3.58359426885511, "Skin exfoliation ": 6.737145521819704, "Skin fissures ": 11.052755173513928, "Skin hypertrophy ": 3.13637128543387, "Skin lesion ": 2.8528256510139136, "Skin necrosis ": 2.8949519108641115, "Skin papilloma ": 2.328719717175764, "Skin reaction ": 3.3555249558991327, "Skin swelling ": 2.223583113398042, "Skin toxicity ": 19.81953950381269, "Skin ulcer ": 5.04497692804652, "Skin wound ": 3.6028465880742018, "Small intestinal haemorrhage ": 5.025707128924461, "Spontaneous bacterial peritonitis ": 11.543509920376112, "Squamous cell carcinoma ": 3.585907864689541, "Squamous cell carcinoma of skin ": 8.954914664525031, "Stevens-Johnson syndrome ": 2.570901837935917, "Stomatitis ": 4.845770834726587, "Thrombotic cerebral infarction ": 10.021200334572695, "Thyroid cancer ": 13.379094114689812, "Thyroid cancer metastatic ": 93.56880461316815, "Tongue blistering ": 2.9083840566205024, "Tongue ulceration ": 3.669896184241869, "Toxic skin eruption ": 4.024337606158823, "Tracheal haemorrhage ": 13.416407925936026, "Transaminases increased ": 3.54633526374638, "Tumour embolism ": 126.33581840400608, "Tumour haemorrhage ": 20.554212242039533, "Tumour invasion ": 15.693968202299128, "Tumour lysis syndrome ": 4.022796509248779, "Tumour marker increased ": 5.3202378299742366, "Tumour necrosis ": 22.585449187161284, "Tumour rupture ": 59.175492977968176, "Tumour thrombosis ": 148.05952665516938, "Upper gastrointestinal haemorrhage ": 2.696728308867445, "Varices oesophageal ": 6.068199854847933, "Varicose vein ruptured ": 64.65052143230412, "Weight decreased ": 2.17963390024521, "Wound dehiscence ": 3.5971583132565668, "Xerosis ": 6.102032463806109, "Yellow skin ": 2.7508372151864373} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/758.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/758.json new file mode 100644 index 00000000000..effd4ec45e5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/758.json @@ -0,0 +1 @@ +{"Graft loss ": 3295.829608504337, "Haemorrhage ": 13.373231443085857, "Off label use ": 7.086259099377228, "Pain ": 17.185945869110345, "Wound complication ": 689.5894839996491, "Wound infection ": 560.1063922133287} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/759.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/759.json new file mode 100644 index 00000000000..5ea47dfd5f9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/759.json @@ -0,0 +1 @@ +{"Arthralgia ": 2.6465026260726554, "Muscle discomfort ": 632.4611504205525, "Muscle spasms ": 13.794132353558789, "Myalgia ": 14.417780807854356} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/76.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/76.json new file mode 100644 index 00000000000..ab2aa58af24 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/76.json @@ -0,0 +1 @@ +{"Live birth ": 139.48583358761417} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/760.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/760.json new file mode 100644 index 00000000000..c993f499312 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/760.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 19.27922283498472, "Acute lymphocytic leukaemia recurrent ": 26.79481134470553, "Acute myocardial infarction ": 8.669747674408413, "Amylase increased ": 9.21739275793892, "Angina pectoris ": 4.542590492063399, "Arterial occlusive disease ": 10.465354402752332, "Arteriosclerosis ": 8.397776624493467, "Atrial fibrillation ": 2.66955785282084, "Blast crisis in myelogenous leukaemia ": 286.3203678106457, "Blood bilirubin increased ": 10.102352696042926, "Bone marrow failure ": 6.393172293640476, "Carotid artery stenosis ": 48.48881012128784, "Cerebral infarction ": 3.666792595541985, "Cerebrovascular accident ": 2.715151057151425, "Chronic myeloid leukaemia ": 158.3877757950397, "Chronic myeloid leukaemia recurrent ": 426.109057707447, "Chronic myeloid leukaemia transformation ": 427.7568557672759, "Coronary artery disease ": 5.716901534865498, "Coronary artery stenosis ": 41.54664126575262, "Cytogenetic analysis abnormal ": 695.3249029532374, "Cytopenia ": 20.32585334241448, "Diabetes mellitus ": 2.232325302117588, "Drug intolerance ": 12.934424257179831, "Drug resistance ": 23.846169402817285, "Dry skin ": 2.470110313204726, "Electrocardiogram QT prolonged ": 9.12100456628418, "Fluid retention ": 2.1735223635987717, "Gastrointestinal stromal tumour ": 11.736393193335884, "Haematotoxicity ": 26.942674821013792, "Hepatotoxicity ": 12.271001638090668, "Hyperbilirubinaemia ": 13.603184943644372, "Hypercholesterolaemia ": 10.103422689135725, "Intermittent claudication ": 154.9842544643605, "Ischaemic stroke ": 5.555166720576056, "Leukocytosis ": 4.618693393519429, "Lipase increased ": 16.270825269823412, "Malignant neoplasm progression ": 7.997743830252789, "Myocardial infarction ": 2.908153651936296, "Myocardial ischaemia ": 14.560143763627284, "Neutropenia ": 2.4572411260781344, "Pancreatitis ": 4.563984729764407, "Pancreatitis acute ": 4.265214066736592, "Pancytopenia ": 5.354800560503826, "Pericardial effusion ": 9.851013085097676, "Pericarditis ": 2.1593319854123867, "Peripheral arterial occlusive disease ": 250.70679987256895, "Peripheral artery occlusion ": 46.78502574437142, "Peripheral artery stenosis ": 363.3881513720295, "Peripheral vascular disorder ": 22.549931040880217, "Philadelphia chromosome positive ": 196.87095117596877, "Platelet count decreased ": 2.9466939666601366, "Pleural effusion ": 7.70811254900449, "Product use in unapproved indication ": 4.127722656021543, "Pulmonary arterial hypertension ": 6.028320894887822, "Pulmonary hypertension ": 6.39518956726823, "Second primary malignancy ": 36.12489304745866, "Skin lesion ": 2.745255098152901, "Splenomegaly ": 9.987489118933468, "Therapeutic response decreased ": 10.967238887376364, "Therapy non-responder ": 7.511798336203002, "Thrombocytopenia ": 6.080852023815987, "Thrombocytosis ": 15.432165365654727, "Transaminases increased ": 2.0239945791846257, "Treatment failure ": 5.478817510500663, "White blood cell count increased ": 3.852166419725144} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/761.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/761.json new file mode 100644 index 00000000000..9b85f7623c4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/761.json @@ -0,0 +1 @@ +{"Acute disseminated encephalomyelitis ": 15.707706326410412, "Allergy to vaccine ": 11.163051616019644, "Angioedema ": 2.0193988998842736, "Body temperature increased ": 3.0589154877873166, "Crying ": 7.764145154594899, "Cyanosis ": 2.734425840642007, "Decreased appetite ": 2.193802118274974, "Encephalitis ": 3.7071687956924055, "Erythema ": 2.2121848386414182, "Extensive swelling of vaccinated limb ": 5.430038249084654, "Eye movement disorder ": 6.689054600506044, "Febrile convulsion ": 45.85029231307813, "Feeling of body temperature change ": 2.3880433608597538, "Gaze palsy ": 4.665709502045421, "Generalised tonic-clonic seizure ": 2.9679871469706884, "Guillain-Barre syndrome ": 2.0029548703560405, "Headache ": 2.3428405774809, "Hyperpyrexia ": 11.590817879324767, "Hypersomnia ": 4.714902671182138, "Hyperthermia ": 2.214580913911386, "Hyporesponsive to stimuli ": 18.797493621394835, "Hypotonia ": 2.367011009428384, "Hypotonic-hyporesponsive episode ": 11.353942900704736, "Immunisation reaction ": 2.48268413298265, "Induration ": 4.377577023650129, "Infant irritability ": 195.46272851523128, "Infantile vomiting ": 69.99738985663316, "Injected limb mobility decreased ": 3.33883993661782, "Injection site discomfort ": 7.488189960521683, "Injection site erythema ": 7.454712751021688, "Injection site inflammation ": 8.70069368119491, "Injection site oedema ": 4.468518269402137, "Injection site pain ": 3.148522282930843, "Injection site pruritus ": 7.378142051352186, "Injection site rash ": 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3.5169239498910576, "Sepsis ": 3.438566071639955, "Thrombosis ": 2.08882954836856, "Upper respiratory tract infection ": 2.1587438697775645, "Urinary tract infection ": 2.4603594319233664, "White blood cell count decreased ": 4.675813905010871} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/763.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/763.json new file mode 100644 index 00000000000..a85b5dff386 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/763.json @@ -0,0 +1 @@ +{"Diarrhoea ": 3.1437602900644626, "Vomiting ": 2.989973493555093} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/764.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/764.json new file mode 100644 index 00000000000..4c5d4f5af15 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/764.json @@ -0,0 +1 @@ +{"Drug interaction ": 29.03088900401679} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/765.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/765.json new file mode 100644 index 00000000000..747f1ff952e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/765.json @@ -0,0 +1 @@ +{"Drug ineffective ": 6.337790220932591, "Pleural effusion ": 19.000574397200637, "Therapy non-responder ": 40.36109660048658} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/766.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/766.json new file mode 100644 index 00000000000..1293d887d27 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/766.json @@ -0,0 +1 @@ +{"Back pain ": 6.015607359172312, "Bone pain ": 40.68673118342683, "Drug ineffective ": 2.88515984082921, "Erythema ": 4.622935345100571, "Febrile neutropenia ": 6.590292384945143, "Neutropenia ": 8.226211923625936, "Neutrophil count decreased ": 10.95394276252234, "Pruritus ": 2.741177310082855, "Therapy non-responder ": 16.099585110706617, "Thrombocytopenia ": 2.720000603483483, "Urticaria ": 2.451921111089596} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/767.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/767.json new file mode 100644 index 00000000000..f53b13bdaf4 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/767.json @@ -0,0 +1 @@ +{"Autoimmune colitis ": 277.12504022806064, "Autoimmune hepatitis ": 17.757873940261966, "Colitis ": 19.19143562446282, "Cytokine release syndrome ": 9.860012062117296, "Diarrhoea ": 2.1930670218441155, "Disease progression ": 2.9191940395170746, "Disseminated intravascular coagulation ": 6.418862853447184, "Febrile neutropenia ": 4.432164173693639, "General physical health deterioration ": 3.6289708757655954, "Hepatitis ": 8.061960965788677, "Hyperthyroidism ": 13.778586527824569, "Hypophysitis ": 43.84328165206169, "Hypothyroidism ": 9.037974754439654, "Hypoxia ": 6.673028803452018, "Immune effector cell-associated neurotoxicity syndrome ": 29.267269951826894, "Immune-mediated enterocolitis ": 19.27855314949008, "Immune-mediated lung disease ": 43.27989002890576, "Intentional product use issue ": 15.92180494662868, "Interstitial lung disease ": 6.806957161231257, "Liver disorder ": 3.7817380314767433, "Malignant neoplasm progression ": 16.770999437033964, "Myelosuppression ": 2.816398540645348, "Myocarditis ": 2.2610322161649843, "Neuropathy peripheral ": 4.59289338589455, "Neutrophil count decreased ": 3.914067922108416, "Off label use ": 2.507685124925671, "Pemphigoid ": 8.241259495879213, "Platelet count decreased ": 2.244857411606162, "Pneumonia aspiration ": 8.820163313211008, "Pneumonitis ": 12.63028930487864, "Rash maculo-papular ": 3.2160327820643664, "Thyroiditis ": 22.22660525458709, "Transaminases increased ": 3.407062401391325, "Tubulointerstitial nephritis ": 12.28610223157174, "White blood cell count decreased ": 2.8638986780071414} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/768.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/768.json new file mode 100644 index 00000000000..043f12b3743 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/768.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 12.206761895527944, "Atrial fibrillation ": 6.665321115464096, "Hyperkalaemia ": 11.223407434579828, "Hypotension ": 9.320587689618486} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/769.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/769.json new file mode 100644 index 00000000000..3df83695419 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/769.json @@ -0,0 +1 @@ +{"Crying ": 35.775660033151794, "Pyrexia ": 2.3064283102326253, "Rash ": 2.4208877249915446} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/77.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/77.json new file mode 100644 index 00000000000..436df79ac1a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/77.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 9.00567855366251, "Completed suicide ": 35.925444641320624, "Drug ineffective ": 2.2254407225223947, "Toxicity to various agents ": 16.31705215644659} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/770.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/770.json new file mode 100644 index 00000000000..e3cc7eab524 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/770.json @@ -0,0 +1 @@ +{"Abortion spontaneous ": 7.254318368077092, "Acute kidney injury ": 5.211057898454889, "Adrenal insufficiency ": 12.192195844638164, "Adverse event ": 2.237508494936895, "Atrioventricular septal defect ": 156.6128739519058, "Blood bilirubin increased ": 9.56020195014718, "Blood creatine phosphokinase increased ": 2.002202934435132, "Blood creatinine increased ": 2.241142161003636, "Blood phosphorus decreased ": 24.19163771582701, "Blood triglycerides increased ": 3.241793039219291, "Caesarean section ": 37.7469176081207, "Calculus urinary ": 112.9198028176019, "Cell death ": 34.658507580573975, "Cervical incompetence ": 116.0334952499294, "Cholecystitis ": 6.794073087952374, "Cholelithiasis ": 9.640760788165757, "Cholestasis ": 8.065466469323013, "Congenital bowing of long bones ": 532.2562342398328, "Conjunctivitis ": 2.0567808723047305, "Coronary artery occlusion ": 4.184810950196142, "Cortisol decreased ": 34.022475760079764, "Cushing's syndrome ": 147.495289442233, "Cushingoid ": 70.86810849352483, "Drug interaction ": 7.566770834400439, "Drug level decreased ": 5.582330660875571, "Drug level increased ": 2.8310270506297863, "Drug reaction with eosinophilia and systemic symptoms ": 5.079185470480707, "Drug withdrawal syndrome neonatal ": 4.830257194988777, "Dyslipidaemia ": 22.02834438013721, "End stage renal disease ": 2.6632980671724806, "Eosinophilia ": 2.248148411607312, "Exposure during pregnancy ": 6.037017700391125, "Eye disorder ": 2.056079777300712, "Eyelid oedema ": 4.209716842282538, "Fanconi syndrome ": 65.88646132650825, "Fanconi syndrome acquired ": 13.237790094603763, "Foetal death ": 9.983281402854429, "Foetal exposure during pregnancy ": 10.133152246833808, "Foetal growth restriction ": 11.290556341965608, "Gestational diabetes ": 28.894697793690543, "Glycosuria ": 13.658677211931511, "Gynaecomastia ": 3.833056649095538, "HIV infection ": 27.34268683994153, "Haemolytic anaemia ": 2.356238692080797, "Heart disease congenital ": 22.051945591775198, "Hepatic cytolysis ": 17.42151593690474, "Hepatic enzyme increased ": 3.0386557845788955, "Hepatic steatosis ": 5.292626917247405, "Hepatitis ": 6.5386685202581765, "Hepatitis C ": 2.3846614160916837, "Hepatotoxicity ": 2.034388551964605, "Heterotaxia ": 182.35772313239215, "Hydronephrosis ": 19.56728830786064, "Hyperbilirubinaemia ": 42.8540899561524, "Hypercapnia ": 12.482923692416897, "Hypercholesterolaemia ": 3.832174146612736, "Hypophosphataemia ": 9.305293571570456, "Immune reconstitution inflammatory syndrome ": 36.19482630371997, "Jaundice ": 17.575446734860776, "Lactic acidosis ": 2.1900375161912287, "Lipodystrophy acquired ": 51.442515404716, "Lipohypertrophy ": 60.87722005330464, "Live birth ": 25.246827942120824, "Low birth weight baby ": 3.490716487831572, "Lymphoma ": 7.656605140753281, "Maternal exposure during pregnancy ": 6.9877197980120105, "Metabolic acidosis ": 2.035549662981824, "Mycobacterium avium complex infection ": 13.744392662934828, "Myoglobin blood increased ": 19.64221659720473, "Nephrolithiasis ": 24.02392613476737, "Nephropathy toxic ": 5.664561806643916, "Neuropathy peripheral ": 2.1148123957168536, "Normal newborn ": 16.84186026990361, "Ocular icterus ": 41.01902061840364, "Oedema ": 2.0137407408963885, "Oral candidiasis ": 3.1838893230475063, "Osteonecrosis ": 2.3158143652694068, "Osteoporosis ": 6.157647300067522, "Pancreatitis ": 3.62235554795027, "Pancreatitis acute ": 2.147938191645139, "Pancreatitis necrotising ": 14.842834958997877, "Patent ductus arteriosus ": 14.95502870289387, "Peripheral motor neuropathy ": 36.550546887176736, "Peripheral sensory neuropathy ": 7.426022793299137, "Polyneuropathy ": 5.739199544723217, "Pregnancy ": 19.068601939595894, "Pregnancy on contraceptive ": 58.381615201498406, "Premature baby ": 7.138323483931827, "Premature delivery ": 9.566251248974568, "Premature labour ": 18.05163915933248, "Premature rupture of membranes ": 36.794002436428336, "Proteinuria ": 7.953206706559948, "Rash macular ": 2.1732448113742127, "Rash maculo-papular ": 6.381747973221551, "Renal colic ": 126.2362430253976, "Renal failure ": 2.4082603796219657, "Renal tubular acidosis ": 32.84003602602806, "Renal tubular disorder ": 79.18725397218712, "Renal tubular necrosis ": 6.1356269078419645, "Rhabdomyolysis ": 3.186967632131719, "Rib fracture ": 2.2766374056063348, "Spinal compression fracture ": 8.421295783284583, "Stillbirth ": 18.583614530309685, "Toxic skin eruption ": 6.115183930949762, "Transaminases increased ": 4.016448649399696, "Tubulointerstitial nephritis ": 4.546324602029553, "Type 1 diabetes mellitus ": 3.2835210247272197, "Uveitis ": 7.044802104637939, "Ventricular fibrillation ": 2.601898624979444, "Ventricular septal defect ": 16.849989176550306, "Viral load increased ": 18.752262737242443} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/771.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/771.json new file mode 100644 index 00000000000..14d4ca7d5d8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/771.json @@ -0,0 +1 @@ +{"Adverse event ": 3.590686376299836, "Angina unstable ": 4.239119553640717, "Apnoea ": 2.2698479644444087, "Atelectasis ": 3.1221692277212894, "Autism spectrum disorder ": 14.291885322595691, "Bacterial infection ": 2.682976584492553, "Blood potassium increased ": 2.2236532236778337, "Body temperature decreased ": 3.2569288712147344, "Bundle branch block left ": 7.8619749980933635, "Candida infection ": 2.76320646320378, "Cardiac arrest ": 4.020238732148068, "Cardio-respiratory arrest ": 5.563850512307703, "Clostridium difficile colitis ": 6.956412937382509, "Completed suicide ": 14.45282963815395, "Crying ": 4.117310786986261, "Cyanosis ": 4.385067069084985, "Cytomegalovirus infection ": 3.03590129454706, "Deafness neurosensory ": 12.530174202446329, "Dehydration ": 2.349773240712988, "Dermatitis contact ": 4.870256629086287, "Drug abuse ": 8.004700452066203, "Drug interaction ": 2.227006661370445, "Drug-induced liver injury ": 2.1596278797698503, "Dysstasia ": 2.2321176366612145, "Encephalopathy ": 2.511557103640587, "Eosinophil count increased ": 2.407488415386257, "Febrile convulsion ": 4.226643834834412, "Febrile neutropenia ": 2.598327012138187, "Haemolytic anaemia ": 2.4442927886467456, "Hepatic artery stenosis ": 316.24411147327004, "Hepatic function abnormal ": 2.731961783495609, "Herpes zoster ": 2.548771515691624, "Hyperlipidaemia ": 3.158938388842871, "Hypotonia ": 4.338967905265661, "Hypotonic-hyporesponsive episode ": 20.812459476653828, "Micturition urgency ": 3.395840337597743, "Nervous system disorder ": 4.132229480147723, "Ophthalmic herpes zoster ": 5.990997569429214, "Overdose ": 5.136330255025773, "Pallor ": 3.717125591331736, "Poisoning ": 3.0863450055831905, "Post herpetic neuralgia ": 9.798881532023334, "Product administration error ": 2.6489762917871937, "Respiratory arrest ": 7.860429297354565, "Second primary malignancy ": 3.2761814822481186, "Serotonin syndrome ": 3.847451254053208, "Suicide attempt ": 2.4339439790766195, "Toxic epidermal necrolysis ": 3.466140014766302, "Toxicity to various agents ": 3.802238221195037, "Tuberculosis ": 4.251922774232854, "Urinary incontinence ": 2.281109379589915, "Urinary tract infection bacterial ": 22.279676895935197, "Urine output decreased ": 3.824418318454219, "Vaccination site inflammation ": 2.5961379245385032, "Ventricular tachycardia ": 2.27077666268135} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/772.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/772.json new file mode 100644 index 00000000000..73680c4bfb5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/772.json @@ -0,0 +1 @@ +{"Blood glucose increased ": 10.042285367449557, "Diabetes mellitus inadequate control ": 38.6016981657808, "Diabetic ketoacidosis ": 12.350700832129338, "Exposure during pregnancy ": 4.833433619030855, "Hyperglycaemia ": 8.589314474132722, "Hypersensitivity ": 2.1337206904577357, "Hypoglycaemia ": 35.05767410149898, "Hypoglycaemic coma ": 165.189958337253, "Injection site pruritus ": 13.209800082830222, "Product dispensing error ": 39.40436118860804, "Product prescribing error ": 30.03727917918204, "Wrong product administered ": 83.92931315587076} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/773.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/773.json new file mode 100644 index 00000000000..18d7d1d2652 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/773.json @@ -0,0 +1 @@ +{"Acidosis ": 8.83169939629433, "Acute kidney injury ": 3.179576466412029, "Aphasia ": 4.743917001567636, "Autoimmune haemolytic anaemia ": 21.04589928996799, "Blood alkaline phosphatase increased ": 2.420845792026028, "Blood glucose decreased ": 2.889050155628556, "Blood glucose increased ": 2.9686170471008397, "Cholestasis ": 4.777065640616162, "Confusional state ": 3.2488741302965143, "Cutaneous vasculitis ": 8.597949967501325, "Diabetes mellitus inadequate control ": 16.849524671917386, "Drug interaction ": 2.55525570098869, "Dysarthria ": 3.80569693573888, "Eczema ": 5.52689235654284, "Eosinophilia ": 10.36986542694903, "Fall ": 2.034365480051007, "Gamma-glutamyltransferase increased ": 3.979566684953581, "Glycosylated haemoglobin increased ": 14.670057517393955, "Haemolytic anaemia ": 9.242107666145804, "Hepatic cytolysis ": 9.237396918335149, "Hepatic function abnormal ": 2.599755096988864, "Hepatitis ": 7.685350525024852, "Hepatitis cholestatic ": 7.083807913223398, "Hyperglycaemia ": 8.824095389220867, "Hyperkalaemia ": 5.269981239572672, "Hypoglycaemia ": 71.20607597732156, "Hypoglycaemic coma ": 124.80168898165324, "Hypoglycaemic seizure ": 45.6029861522495, "Hypoglycaemic unconsciousness ": 11.314966706868717, "Hyponatraemia ": 2.391470496955677, "Hypotension ": 2.094164582825625, "Jaundice ": 3.630345755487389, "Lactic acidosis ": 8.07938423012479, "Medication error ": 3.409721139114368, "Pancreatitis ": 2.964748557750767, "Pemphigoid ": 6.719764484327032, "Petechiae ": 2.9587553744478896, "Presyncope ": 2.031940858440355, "Pruritus ": 2.792910358094476, "Purpura ": 4.640106985486704, "Rash erythematous ": 2.9568521690083385, "Rash maculo-papular ": 3.134509368537787, "Rhabdomyolysis ": 3.2965332850104714, "Sopor ": 32.19721331352718, "Stevens-Johnson syndrome ": 2.516191609823207, "Thrombocytopenia ": 2.3743782240369784, "Toxic skin eruption ": 10.655662568813671, "Transaminases increased ": 3.1544603252198127, "Vascular purpura ": 32.95197618923166} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/774.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/774.json new file mode 100644 index 00000000000..267bcd40ce3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/774.json @@ -0,0 +1 @@ +{"Accidental overdose ": 2.494252812938781, "Acetonaemia ": 31.514305333600795, "Anti-insulin antibody ": 286.48426815482804, "Anti-insulin antibody increased ": 110.0534227974708, "Anti-insulin antibody positive ": 125.76838697673116, "Blood glucose abnormal ": 39.75551157948605, "Blood glucose decreased ": 13.582459517961498, "Blood glucose fluctuation ": 56.583154744522645, "Blood glucose increased ": 62.05921934681912, "Blood ketone body ": 102.03766450034472, "Blood ketone body increased ": 89.67966453289556, "Blood ketone body present ": 1137.230427559035, "Cardiac operation ": 2.428297073316964, "Device breakage ": 81.84880374389091, "Device defective ": 34.47464415034286, "Device delivery system issue ": 42.2995124722648, "Device failure ": 82.04485592353478, "Device information output issue ": 239.37985664292012, "Device issue ": 30.279035304452343, "Device leakage ": 26.34448268205088, "Device malfunction ": 24.469430004656537, "Device mechanical issue ": 53.05827220231231, "Device occlusion ": 11.124646932472244, "Diabetes mellitus inadequate control ": 22.655253030706724, "Diabetic coma ": 4.533220415054642, "Diabetic foot ": 7.206626437068032, "Diabetic hyperglycaemic coma ": 39.17742908418572, "Diabetic ketoacidosis ": 46.18896473969487, "Diabetic ketoacidotic hyperglycaemic coma ": 39.75700705592475, "Diabetic ketosis ": 51.01979435211996, "Diabetic metabolic decompensation ": 9.84286379241238, "Diabetic retinopathy ": 9.194256592183038, "Drug effect less than expected ": 6.99623203876677, "Drug ineffective ": 3.5574089786754777, "Expired device used ": 49.00452325977799, "Expired product administered ": 3.846701851471861, "Exposure during pregnancy ": 3.0728010151267915, "Extra dose administered ": 11.69138153834254, "Foetal death ": 3.064037414838908, "Foetal distress syndrome ": 4.268012105755982, "Foetal exposure during pregnancy ": 3.1021002757896534, "Foetal growth restriction ": 4.8300422246110815, "Glycosylated haemoglobin abnormal ": 10.467937207372954, "Glycosylated haemoglobin increased ": 8.753577792273283, "Hunger ": 3.888563228743098, "Hyperglycaemia ": 83.28236223461992, "Hyperglycaemic unconsciousness ": 34.30867187137813, "Hyperinsulinaemic hypoglycaemia ": 23.778744399440228, "Hypoglycaemia ": 35.701191685792395, "Hypoglycaemia neonatal ": 13.321213904900002, "Hypoglycaemia unawareness ": 61.924815308449226, "Hypoglycaemic coma ": 40.732862030309256, "Hypoglycaemic encephalopathy ": 35.47961488533972, "Hypoglycaemic seizure ": 30.327697679174417, "Hypoglycaemic unconsciousness ": 49.929967348883615, "Incorrect dose administered ": 3.7889825724727375, "Incorrect dose administered by device ": 80.0238247811495, "Incorrect dose administered by product ": 31.850682159709184, "Increased insulin requirement ": 122.6253279074092, "Injection site atrophy ": 68.0236216001251, "Injection site hypersensitivity ": 4.817707583247729, "Injection site induration ": 3.4819774416232767, "Injection site mass ": 3.907895879742018, "Injection site rash ": 3.214744312999425, "Injection site urticaria ": 3.667253414712229, "Insulin resistance ": 17.916036704348898, "Intentional overdose ": 3.0614023831950026, "Ketoacidosis ": 8.495371101314843, "Ketosis ": 15.509255853264104, "Lack of injection site rotation ": 29.727780283293317, "Lipoatrophy ": 28.799145734600717, "Lipodystrophy acquired ": 5.226307908481054, "Lipohypertrophy ": 11.228253514148156, "Liquid product physical issue ": 388.0570938410197, "Maternal exposure during pregnancy ": 2.026240384028059, "Medication error ": 3.0556670585330057, "Multiple use of single-use product ": 16.014334764099562, "Needle issue ": 3.167046360729976, "Postprandial hypoglycaemia ": 97.1444273327776, "Pregnancy ": 2.5004122990402022, "Premature baby ": 4.686371898358253, "Premature delivery ": 2.7337242401064725, "Product administration error ": 2.517178850624717, "Product appearance confusion ": 16.30443179020188, "Product colour issue ": 8.00412571229209, "Product container issue ": 267.482597579064, "Product dispensing error ": 2.2251275871619924, "Product leakage ": 2060.6516560101154, "Product odour abnormal ": 19.287825546322203, "Product physical issue ": 278.4674230502161, "Product preparation error ": 8.550148413329795, "Product quality issue ": 43.95207905871248, "Product storage error ": 19.74191149168975, "Shock hypoglycaemic ": 11.988244192051583, "Suicide attempt ": 2.7650058371984563, "Suspected counterfeit product ": 3.388987555056583, "Suspected product quality issue ": 4.982845235291706, "Therapeutic product effect decreased ": 3.4513376420951225, "Therapeutic product effect delayed ": 27.396337164269465, "Therapeutic product effect variable ": 7.985875415631403, "Thrombin time prolonged ": 119.58125356646327, "Treatment noncompliance ": 2.207815894259765, "Urine ketone body present ": 32.5216082534543, "Wrong product administered ": 12.17244398819975, "Wrong technique in device usage process ": 5.895279498626724, "Wrong technique in product usage process ": 13.286197041593647} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/775.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/775.json new file mode 100644 index 00000000000..56305c965dc --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/775.json @@ -0,0 +1 @@ +{"Abdominal sepsis ": 156.82509829685773, "Acute myocardial infarction ": 9.381868743964557, "Acute respiratory distress syndrome ": 10.83044446029163, "Anaphylactic reaction ": 2.590083057009188, "Anti factor VII antibody positive ": 4404.315166762161, "Antibody test positive ": 52.64303882449443, "Aortic thrombosis ": 74.40118164937415, "Arterial thrombosis ": 55.73916270229012, "Atrial thrombosis ": 54.12663883398388, "Brain death ": 25.612816933672114, "Brain injury ": 6.294831099992516, "Cardiac arrest ": 4.81014164974593, "Cardiac ventricular thrombosis ": 41.58012002717472, "Cardio-respiratory arrest ": 2.245226836950024, "Cerebral artery thrombosis ": 76.9067716569572, "Cerebral haemorrhage ": 4.722719853344857, "Cerebral infarction ": 24.097896312405474, "Cerebral ischaemia ": 49.06690376038344, "Cerebral thrombosis ": 21.579610112702134, "Cerebral venous sinus thrombosis ": 11.29863909780962, "Cerebrovascular accident ": 4.332363581482891, "Complication associated with device ": 31.177213612479523, "Concomitant disease progression ": 1018.7300870919788, "Coronary bypass thrombosis ": 1849.405728704364, "Death ": 8.805686075534213, "Deep vein thrombosis ": 20.65426123238788, "Device related thrombosis ": 73.5638634286628, "Dialysis ": 37.984717029716926, "Disseminated intravascular coagulation ": 46.49702813315186, "Drug ineffective ": 4.793173234629237, "Drug ineffective for unapproved indication ": 8.8789786987713, "Embolic stroke ": 27.60877028983399, "Embolism ": 33.62984673505934, "Embolism venous ": 26.891865923093462, "Exsanguination ": 960.9056807734388, "Factor VII inhibition ": 5911.667594544416, "Factor VIII inhibition ": 30.2553417773186, "Haemarthrosis ": 42.15458499907231, "Haematoma ": 6.861519736742956, "Haematuria ": 6.422925631293882, "Haemoperitoneum ": 31.41375430989804, "Haemorrhage ": 17.61263571739453, "Haemorrhage intracranial ": 18.8527181572159, "Haemothorax ": 27.37382281177756, "Hemiparesis ": 4.604553943933594, "Hepatic failure ": 3.888384459819625, "Hepatitis C ": 2.0385591352302272, "Hydrocephalus ": 12.765679601474098, "Hypovolaemic shock ": 27.48841974177974, "Intestinal ischaemia ": 38.035769153883145, "Intra-abdominal haemorrhage ": 26.907526308012773, "Intrapericardial thrombosis ": 1585.301723097751, "Ischaemia ": 16.876166078491035, "Ischaemic stroke ": 14.52672044546472, "Jugular vein thrombosis ": 71.44507794814716, "Knee arthroplasty ": 4.52778934410037, "Mesenteric vein thrombosis ": 48.53319812038328, "Multiple organ dysfunction syndrome ": 39.48044985677456, "Muscle haemorrhage ": 35.37199944726619, "Myocardial infarction ": 5.689921343228859, "Myocardial ischaemia ": 6.970902287729764, "Necrosis ": 15.89311978233603, "Off label use ": 5.0940904456049765, "Pelvic venous thrombosis ": 96.6587143580445, "Peripheral artery thrombosis ": 137.68330558704656, "Peripheral ischaemia ": 55.96816978497376, "Portal vein thrombosis ": 34.18865079316216, "Post procedural haemorrhage ": 18.917217920078333, "Postpartum haemorrhage ": 49.250872995599, "Pulmonary embolism ": 16.17265945187263, "Pulmonary haemorrhage ": 16.943045039242946, "Pulmonary oedema ": 2.615455282803346, "Renal cortical necrosis ": 426.38523158099525, "Respiratory distress ": 2.664804157544525, "Sepsis ": 7.082085622208874, "Septic shock ": 8.011561883013968, "Shock ": 4.882720249727275, "Shock haemorrhagic ": 48.33520035500083, "Subarachnoid haemorrhage ": 5.5505605038922665, "Subclavian vein thrombosis ": 109.26752282674882, "Therapeutic response decreased ": 42.53762691843345, "Therapy non-responder ": 2.6224624656119526, "Thrombosis ": 12.16081409048568, "Thrombosis in device ": 36.71735091326151, "Thrombotic stroke ": 202.00877410635283, "Vena cava thrombosis ": 169.02767191097865, "Venous thrombosis ": 28.67044132554181, "Venous thrombosis limb ": 26.47923832804478} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/776.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/776.json new file mode 100644 index 00000000000..ed397541c3e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/776.json @@ -0,0 +1 @@ +{"Acquired apparent mineralocorticoid excess ": 2864.886879155343, "Acute kidney injury ": 2.3852890717477555, "Acute myeloid leukaemia ": 24.785084851839628, "Acute respiratory failure ": 4.208014704671731, "Adrenal insufficiency ": 3.9711009107998536, "Adverse event ": 22.59553898658379, "Aspartate aminotransferase increased ": 2.4028057381702985, "Aspergillus infection ": 30.32686296215917, "Bilirubin conjugated increased ": 20.31168938613883, "Blood alkaline phosphatase increased ": 3.31284119327257, "Blood bilirubin increased ": 3.69024215970927, "Blood potassium decreased ": 2.945177435864435, "Bone marrow transplant ": 41.72220930244511, "Brain oedema ": 3.990498097432586, "Bronchopulmonary aspergillosis ": 38.15860262220375, "Cardiac arrest ": 2.0398123914579114, "Cholestasis ": 14.473180428141289, "Clostridium difficile colitis ": 6.237991797570545, "Death ": 6.051921372326699, "Disseminated intravascular coagulation ": 3.526934410348404, "Drug eruption ": 2.432980672758028, "Drug interaction ": 4.8728660879750905, "Drug level below therapeutic ": 65.37934506990794, "Drug level decreased ": 27.332020931715466, "Drug level increased ": 10.15602281033183, "Drug-induced liver injury ": 11.350082414503678, "Electrocardiogram QT prolonged ": 12.799748002865092, "Febrile neutropenia ": 4.697960667887392, "Fungal infection ": 8.594273963669927, "Fusarium infection ": 83.96084495144952, "Gamma-glutamyltransferase increased ": 5.3613844045880565, "Gastrointestinal tube insertion ": 16.854719342134363, "Graft versus host disease ": 30.741090940429768, "Graft versus host disease in gastrointestinal tract ": 20.70373000431945, "Hallucination, visual ": 3.4786890835323323, "Hepatic cytolysis ": 16.68721068391925, "Hepatic enzyme increased ": 3.214384020088055, "Hepatic failure ": 3.2106361777137837, "Hepatic function abnormal ": 2.9074267306114456, "Hepatitis ": 2.826114714885663, "Hepatitis cholestatic ": 4.309402186794785, "Hepatotoxicity ": 9.44454040464298, "Hyperbilirubinaemia ": 12.02073830328612, "Hypertransaminasaemia ": 9.717181600805674, "Hypokalaemia ": 18.0082903154935, "Hypomagnesaemia ": 13.258917634714832, "Ileus ": 4.532827050205031, "Ileus paralytic ": 11.322323292353287, "Inappropriate schedule of product administration ": 2.6324839157921502, "Incorrect dose administered ": 5.624872202858161, "Incorrect product dosage form administered ": 121.41060628921166, "Incorrect route of product administration ": 3.450011556572698, "Infection ": 2.389487812297622, "Intestinal haemorrhage ": 13.06149933180976, "Jaundice ": 2.3434798526277407, "Leukaemia ": 21.38399227889401, "Leukaemia recurrent ": 24.593829632849364, "Liver function test increased ": 4.335560642673161, "Liver injury ": 5.327940108793181, "Malabsorption ": 10.608870916373665, "Mucormycosis ": 29.03308476274195, "Mucosal inflammation ": 2.6580712168914555, "Multiple organ dysfunction syndrome ": 2.4287226916008247, "Myelodysplastic syndrome ": 11.827850148551256, "Neuralgia ": 2.1974396879125173, "Neurotoxicity ": 6.764302951957865, "Neutropenia ": 2.096169743875733, "Neutropenic colitis ": 39.42474232419959, "Oedematous pancreatitis ": 80.13697504153676, "Pancytopenia ": 2.8009232853139765, "Pathogen resistance ": 5.083665961297556, "Pericardial effusion ": 2.384937464532678, "Pneumonia fungal ": 53.83966995819555, "Polyneuropathy ": 2.94554929983637, "Posterior reversible encephalopathy syndrome ": 6.140828521412818, "Potentiating drug interaction ": 12.11631913255806, "Prescribed overdose ": 4.341061389787439, "Primary adrenal insufficiency ": 124.51802954776834, "Product administered to patient of inappropriate age ": 9.057095832837096, "Product administration error ": 2.076004331048994, "Product prescribing error ": 9.248677374246196, "Product quality issue ": 2.685614224675173, "Product use in unapproved indication ": 4.556961834277461, "Product use issue ": 4.942068034371759, "Pseudoaldosteronism ": 411.6086505306429, "Pulmonary arterial hypertension ": 5.0337067460999245, "Pulmonary mass ": 4.456824297816995, "Rash maculo-papular ": 5.526468746979514, "Respiratory failure ": 2.230110438408157, "Rhabdomyolysis ": 2.626002675550662, "Sepsis ": 2.869312625301245, "Septic shock ": 4.28646637287122, "Surgery ": 2.16621510444783, "Systemic candida ": 33.47062391872174, "Systemic mycosis ": 60.837678206015845, "Therapeutic product ineffective ": 44.95315197238797, "Torsade de pointes ": 5.670727954872186, "Toxic skin eruption ": 5.3662063533103606, "Transaminases increased ": 2.3729938327800726, "Transplant ": 31.952443550984203, "Ventricular fibrillation ": 3.404301669823714, "Ventricular tachycardia ": 2.1577874157700605} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/777.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/777.json new file mode 100644 index 00000000000..0b12cbb6fdb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/777.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 3.087925402979168, "Acute leukaemia ": 11.176246968425763, "Acute myeloid leukaemia ": 17.345181884714155, "Acute myocardial infarction ": 3.7500235484250375, "Acute respiratory distress syndrome ": 2.977634247453474, "Acute respiratory failure ": 3.064471804300969, "Antibody test positive ": 20.66925026279972, "Aplastic anaemia ": 8.982684556704914, "Atelectasis ": 4.484617580991387, "Bacteraemia ": 3.389601660596536, "Biopsy bone marrow abnormal ": 626.922686658039, "Blast cell count increased ": 18.90257243573125, "Blood blister ": 15.059613537086902, "Bone marrow disorder ": 34.29551846940135, "Bone marrow failure ": 2.7653250396083124, "Cardiac failure congestive ": 3.0831628535593083, "Cardiac operation ": 3.292851521059287, "Cerebrovascular accident ": 2.218281948621779, "Chronic lymphocytic leukaemia ": 65.19615218052027, "Chronic myeloid leukaemia ": 7.391607919050483, "Chronic myelomonocytic leukaemia ": 94.18328327149382, "Chronic obstructive pulmonary disease ": 2.272520148987166, "Colon cancer ": 2.439802816128359, "Contusion ": 4.031802295293554, "Death ": 4.6084819653539855, "Deep vein thrombosis ": 6.6693390811726845, "Drug ineffective ": 4.708756064623125, "Ecchymosis ": 10.495947772092176, "Embolic stroke ": 5.517723805720633, "Embolism ": 19.10742456150288, "End stage renal disease ": 2.08161450725286, "Epistaxis ": 3.814291566420444, "Evans syndrome ": 88.72577118324857, "Failure to thrive ": 8.235299558146043, "Fibrosis ": 8.887544667574392, "Gastrointestinal haemorrhage ": 3.2976614403712707, "Gingival bleeding ": 5.727288356321504, "Haematological malignancy ": 89.06962410391, "Haemolysis ": 2.371862999466807, "Haemolytic anaemia ": 3.15142464965738, "Haemorrhage ": 5.925795297407532, "Haemorrhage intracranial ": 6.177479515365452, "Haemorrhagic diathesis ": 6.169661660172122, "Hepatic cirrhosis ": 5.375563519809614, "Hospitalisation ": 10.694966266236486, "Hypervolaemia ": 2.727583185079108, "Immune thrombocytopenia ": 19.30216738565376, "Immunosuppression ": 5.897940324943267, "Increased tendency to bruise ": 7.163117585870479, "Iron deficiency anaemia ": 2.9437158384846045, "Ischaemic stroke ": 2.3602931562124865, "Leukaemia ": 5.240278610971806, "Leukocytosis ": 10.095916600891856, "Loss of therapeutic response ": 11.631305082728998, "Lung cancer metastatic ": 11.467003295264314, "Lung infiltration ": 2.1311599455599515, "Lung neoplasm malignant ": 3.222570331459524, "Lymphoma ": 11.45106539331197, "Malnutrition ": 6.010383354639162, "Marrow hyperplasia ": 37.25801268760016, "Megakaryocytes increased ": 116.04096468830942, "Metastases to central nervous system ": 2.2319180727125825, "Mouth haemorrhage ": 14.5808009714183, "Mucosal haemorrhage ": 32.88185867075616, "Multimorbidity ": 70.97405534452291, "Myelodysplastic syndrome ": 45.83262020298119, "Myelofibrosis ": 172.97106796132394, "Myeloproliferative neoplasm ": 33.1015936978901, "Neutrophilia ": 7.265477843620469, "Non-Hodgkin's lymphoma ": 15.2589506438617, "Normochromic normocytic anaemia ": 6.497698601778965, "Oedema peripheral ": 2.073364648811989, "Ovarian cancer ": 5.093898146353857, "Pancytopenia ": 2.8743240396404888, "Petechiae ": 13.91609803673088, "Plasma cell myeloma ": 3.043583585862543, "Platelet count abnormal ": 460.8840840660201, "Platelet count decreased ": 23.80966116232555, "Platelet count increased ": 57.43959250496793, "Platelet disorder ": 28.565846645997446, "Pleural effusion ": 4.769703720102466, "Pneumonia ": 2.0303820629317406, "Portal hypertension ": 6.3400550753037965, "Portal vein thrombosis ": 9.267955716133097, "Post procedural complication ": 3.8925661779645377, "Pulmonary embolism ": 3.889300773120176, "Pulmonary haemorrhage ": 4.167726210467282, "Purpura ": 4.146955793793382, "Refusal of treatment by patient ": 28.88365778285081, "Respiratory failure ": 3.5677381090846887, "Sepsis ": 4.192723972528166, "Skin haemorrhage ": 5.2744455099479, "Splenectomy ": 311.73620254576184, "Splenomegaly ": 8.178013985838023, "Subdural haematoma ": 3.1179691023027325, "Surgery ": 3.460631573381158, "Therapeutic product effect decreased ": 6.578052971960744, "Therapeutic response decreased ": 83.09796888638398, "Therapy non-responder ": 7.145311460460656, "Thrombocytopenia ": 7.866046156448394, "Thrombocytosis ": 43.84949571751786, "Thrombosis ": 4.1292473083755565, "Treatment noncompliance ": 2.0192496068647863, "Unevaluable event ": 3.153059293777298, "Venous thrombosis ": 3.3918256674430105, "Viral infection ": 2.617038220945177, "White blood cell count increased ": 4.054179709338397} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/778.json 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/780.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/780.json new file mode 100644 index 00000000000..e4eeca6881e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/780.json @@ -0,0 +1 @@ +{"Accidental exposure to product ": 3.5218586355888664, "Addison's disease ": 54.51033010058474, "Adverse drug reaction ": 3.607589687386088, "Antineutrophil cytoplasmic antibody ": 90.51391258008884, "Aphonia ": 2.2660679947393056, "Appetite disorder ": 2.5267073739393293, "Areflexia ": 2.7301664594454587, "Asphyxia ": 2.0587769838947976, "Aspiration ": 4.9843300911235415, "Asthma ": 29.15553155286551, "Asthmatic crisis ": 56.63213649759543, "Atelectasis ": 7.488699292738349, "Blood calcium increased ": 3.115085452267677, "Blood immunoglobulin E increased ": 4.54511312955349, "Blood lactic acid increased ": 40.259823225568354, "Blood potassium decreased ": 14.982065620990562, "Blood test abnormal ": 5.777465402095108, "Breath sounds abnormal ": 73.47428160643537, "Bronchial hyperreactivity ": 6.511848256408243, "Bronchial obstruction ": 18.436061770516137, "Bronchial secretion retention ": 11.75302990976973, "Bronchial wall thickening ": 27.33815615126919, "Bronchiectasis ": 13.944320408380218, "Bronchitis ": 4.293013463825864, "Bronchopulmonary aspergillosis allergic ": 35.292782774382566, "Bronchospasm ": 3.5906078473650016, "Chest X-ray abnormal ": 65.1313711858788, "Chest discomfort ": 5.256251788860213, "Choking ": 2.7782184905837437, "Chronic obstructive pulmonary disease ": 2.74879855952992, "Chronic sinusitis ": 8.771773175649724, "Circumstance or information capable of leading to medication error ": 2.598652114433037, "Condition aggravated ": 2.546617939314827, "Coronavirus infection ": 7.874167899892764, "Coronavirus test positive ": 34.91366486644537, "Costochondritis ": 2.7969943388596783, "Cough ": 5.687454229874471, "Crepitations ": 5.7458121102828015, "Cushingoid ": 5.550538277420239, "Cystitis ": 7.1193810432333375, "Decreased activity ": 4.226112438147708, "Decreased immune responsiveness ": 2.020636795964992, "Depressive symptom ": 2.385547425297526, "Discouragement ": 6.936627179755137, "Disease recurrence ": 2.864808161385091, "Drug effective for unapproved indication ": 2.2245982795728616, "Dysphonia ": 2.078571297234622, "Dyspnoea ": 4.560843310605736, "Dyspnoea exertional ": 6.0232642095907, "Ear disorder ": 2.4052074984885774, "Ear pruritus ": 77.35007943592682, "Eczema ": 3.318838805740992, "Emergency care ": 7.68482735417072, "Emphysema ": 4.2438251962019455, "Endotracheal intubation ": 2.146490429448382, "Eosinophil count abnormal ": 47.422038003134645, "Eosinophil count decreased ": 10.040416379536142, "Eosinophil count increased ": 16.00585565035049, "Eosinophilia ": 9.331775714589345, "Eosinophilic granulomatosis with polyangiitis ": 10.801868831141098, "Exercise tolerance decreased ": 2.5743509484196205, "Exposure via skin contact ": 69.02797586140414, "Eye paraesthesia ": 34.26641955359657, "Eye pruritus ": 16.47889463962502, "Eye swelling ": 4.59107640911883, "Facial discomfort ": 5.504395214122872, "Fear of injection ": 16.948859976954825, "Flank pain ": 2.0012056515420373, "Forced expiratory volume decreased ": 10.266101818017672, "Forced expiratory volume increased ": 101.09095623438807, "Forced vital capacity decreased ": 33.55650450346649, "Full blood count abnormal ": 48.52047214251426, "Glaucoma ": 3.118923398213462, "Glucose tolerance impaired ": 3.803117986316304, "Goitre ": 3.524571283344288, "Haemophilus infection ": 25.818799675999053, "Haemoptysis ": 4.947750098599382, "Heart sounds ": 38.88681779653847, "Hospitalisation ": 4.702095792755077, "Hypereosinophilic syndrome ": 21.410970149285266, "Hypersensitivity pneumonitis ": 5.442411682079951, "Hypoventilation ": 5.318175688124239, "Ill-defined disorder ": 2.1149261151146166, "Illness ": 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4.715258109487136, "Rales ": 2.9297755110967154, "Rash erythematous ": 2.306004017275608, "Respiration abnormal ": 3.466113310119357, "Respiratory disorder ": 2.870849392494544, "Respiratory symptom ": 12.58699667424182, "Respiratory tract congestion ": 2.7244459686056373, "Respiratory tract infection ": 6.246309394523245, "Respiratory tract inflammation ": 17.555974229529102, "Restrictive pulmonary disease ": 14.675793833963285, "Reversible airways obstruction ": 13.911099665157383, "Rhinitis ": 4.082721937641772, "Rhinitis allergic ": 33.946734373763285, "Rhinorrhoea ": 7.345957782910604, "Rhonchi ": 8.904008941358247, "Scratch ": 5.729787806531688, "Seasonal allergy ": 12.068956122152686, "Secretion discharge ": 11.021208206452304, "Sense of oppression ": 5.056920313384757, "Sensitivity to weather change ": 4.195474716363843, "Sinonasal obstruction ": 34.29703659789128, "Sinus congestion ": 4.600022501682807, "Sinus disorder ": 2.560227120934633, "Sinus operation ": 8.964327499965702, "Sinusitis ": 5.587272853487301, "Skin fragility ": 16.48256749082065, "Skin laceration ": 2.0639544237429783, "Sleep disorder ": 2.593641060892796, "Sleep disorder due to a general medical condition ": 65.7299016530361, "Sneezing ": 16.031872127516685, "Social problem ": 16.87482700352584, "Spirometry abnormal ": 14.517285159092827, "Sputum abnormal ": 8.203618624413462, "Sputum discoloured ": 26.611245096240008, "Sputum purulent ": 16.456441624276096, "Sputum retention ": 21.661509990296125, "Surgery ": 2.311737178570053, "Symptom recurrence ": 4.96630252462112, "Therapeutic product effect incomplete ": 24.457094261444837, "Therapeutic response decreased ": 3.2429499302590523, "Therapy cessation ": 4.22584739676654, "Therapy interrupted ": 11.651533274925027, "Total lung capacity increased ": 12.582571534263272, "Tracheomalacia ": 17.997598113826598, "Tumour excision ": 12.919994594572508, "Upper respiratory tract congestion ": 6.57909633302121, "Upper respiratory tract infection ": 3.2238681238271245, "Upper-airway cough syndrome ": 64.30722268327983, "Urinary tract disorder ": 4.849096109410918, "Use of accessory respiratory muscles ": 38.43816974395397, "Vasculitis ": 13.480226469708178, "Viral infection ": 2.2828609024379247, "Vital capacity decreased ": 37.23038751428189, "Vocal cord dysfunction ": 10.766900999354563, "Vulvovaginal candidiasis ": 2.5850782775963808, "Wheezing ": 37.915359059490925, "Wrong technique in device usage process ": 7.756983701620193} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/781.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/781.json new file mode 100644 index 00000000000..d9415f9670f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/781.json @@ -0,0 +1 @@ +{"Vomiting ": 2.348133439257855} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/782.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/782.json new file mode 100644 index 00000000000..c56642c69ee --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/782.json @@ -0,0 +1 @@ +{"Myalgia ": 4.250344691869928} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/783.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/783.json new file mode 100644 index 00000000000..ec88c91ac4b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/783.json @@ -0,0 +1 @@ +{"Epiphysiolysis ": 882.160968263104, "Intracranial pressure increased ": 66.21940442186816, "Meningioma ": 137.41681124373372, "Pneumonia ": 2.8336723434818083, "Scoliosis ": 165.5105509865673, "Seizure ": 2.878030355072476} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/784.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/784.json new file mode 100644 index 00000000000..6cdbfbd9442 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/784.json @@ -0,0 +1 @@ +{"Injection site haematoma ": 67.45453114642442, "Injection site pain ": 7.479922708016208} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/785.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/785.json new file mode 100644 index 00000000000..4c96fd326c6 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/785.json @@ -0,0 +1 @@ +{"Gamma-glutamyltransferase abnormal ": 1002.8322798423314, "Hepatic cirrhosis ": 52.45252841805807, "Product dose omission issue ": 6.862924498692259, "Pruritus ": 12.693377056655589} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/786.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/786.json new file mode 100644 index 00000000000..12a54863d74 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/786.json @@ -0,0 +1 @@ +{"Anaemia ": 3.04461810338983, "COVID-19 ": 3.1403432501461808, "COVID-19 pneumonia ": 35.547773488051604, "Cardiac disorder ": 3.986779381085997, "Chest discomfort ": 2.088978036511576, "Chronic lymphocytic leukaemia ": 32.88237100336362, "Cytokine release syndrome ": 4.613834293176742, "Cytomegalovirus chorioretinitis ": 38.14957595414204, "Cytomegalovirus infection ": 11.536225675524626, "Diffuse large B-cell lymphoma ": 16.381827453046256, "Disease progression ": 10.809035855524188, "Encephalopathy ": 3.36156516715479, "Febrile neutropenia ": 15.055158129567705, "Follicular lymphoma ": 363.2573263171178, "Haematotoxicity ": 12.510331163226136, "Hypogammaglobulinaemia ": 55.98488618870621, "Hypotension ": 2.11815358719954, "Infection ": 2.104484747780238, "Infusion related reaction ": 23.44582970320656, "Intentional product use issue ": 3.3335878198901407, "Lower respiratory tract infection ": 3.6044861194639073, "Lymphocyte count decreased ": 21.73966608870621, "Myelosuppression ": 9.993352816734342, "Neutropenia ": 17.50607540846971, "Neutropenic sepsis ": 26.11896152102213, "Neutrophil count decreased ": 7.683365102059168, "Off label use ": 4.034087234644688, "Oxygen saturation decreased ": 3.634564435890242, "Pancytopenia ": 2.248656063809772, "Platelet count decreased ": 5.313792504208246, "Pneumonia ": 5.5362657128565536, "Prescribed underdose ": 59.929557590833554, "Progressive multifocal leukoencephalopathy ": 24.636375546315737, "Septic shock ": 4.43836908477213, "Therapy partial responder ": 17.4979119892943, "Thrombocytopenia ": 8.375632949669955, "Tumour lysis syndrome ": 105.11442352676312, "Urinary tract infection ": 2.4348901757067654, "White blood cell count decreased ": 3.640182497062746} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/787.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/787.json new file mode 100644 index 00000000000..379a3ad4c8f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/787.json @@ -0,0 +1 @@ +{"Abdominal distension ": 4.050580729989552, "Alanine aminotransferase increased ": 3.1516736017069285, "Ascites ": 15.496527183662744, "Aspartate aminotransferase abnormal ": 79.22118340654633, "Aspartate aminotransferase increased ": 3.3833438359343453, "Blood albumin decreased ": 17.153475142848897, "Blood alkaline phosphatase abnormal ": 653.362880489703, "Blood alkaline phosphatase increased ": 26.190048824191013, "Blood bilirubin abnormal ": 88.7207386379766, "Blood bilirubin increased ": 30.106597693477987, "Child-Pugh-Turcotte score 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11.790712629326505, "Liver disorder ": 2.315184593772416, "Liver function test increased ": 4.70692040957297, "Liver transplant ": 62.27696103920935, "Model for end stage liver disease score increased ": 3834.7455166239465, "Nervousness ": 2.500585402662928, "No adverse event ": 4.274842085440388, "Ocular icterus ": 16.88078745165721, "Oedema peripheral ": 2.6813740826178183, "Oesophageal varices haemorrhage ": 39.952015691301774, "Oral pain ": 3.645594118980828, "Portal hypertension ": 23.18355387462372, "Primary biliary cholangitis ": 131.2628631456531, "Product dose omission issue ": 4.929712691411372, "Product prescribing error ": 15.9354432815253, "Pruritus ": 13.14567507731868, "Skin haemorrhage ": 12.113433842089394, "Skin lesion ": 2.2192977404845484, "Splenomegaly ": 6.826762285652174, "Surgery ": 3.3667616356496044, "Therapy interrupted ": 57.92968715427239, "Transaminases increased ": 2.7240231985321826, "Treatment noncompliance ": 3.8220451455064, "Urinary tract infection ": 2.3210663771414404, "Varices oesophageal ": 24.7514758920342, "Viral infection ": 2.96029910183373, "Yellow skin ": 10.414216359918186} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/788.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/788.json new file mode 100644 index 00000000000..11f6eaad781 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/788.json @@ -0,0 +1 @@ +{"Abdominal pain ": 4.280217286548042, "Anal incontinence ": 143.4849730525466, "Arthropathy ": 17.62765613959282, "Back pain ": 6.007984708625272, "Bacterial disease carrier ": 1932.5772961263, "Bronchiectasis ": 179.1479124851229, "Carpal tunnel syndrome ": 134.7226658250234, "Chronic respiratory failure ": 1247.990565363114, "Decubitus ulcer ": 276.19978532385227, "Depression ": 6.944386209982682, "Dysphagia ": 14.487076422584666, "Enterobacter infection ": 1176.461061785761, "Hypertonia 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/789.json @@ -0,0 +1 @@ +{"Agitation ": 2.0781078963859687, "Ankle fracture ": 11.93051982137408, "Balance disorder ": 6.40007148496775, "Burning sensation ": 2.048363051342529, "Colitis ulcerative ": 4.479616177531013, "Cystitis ": 9.502557385770825, "Depressed mood ": 3.943279236267077, "Depression ": 2.663208415682806, "Drug hypersensitivity ": 2.3120015287754905, "Dysuria ": 4.783148104567157, "Fall ": 3.3049713627916786, "Feeling abnormal ": 4.286433740276772, "Flushing ": 8.826861607626638, "Gait disturbance ": 3.157758411947072, "Gait inability ": 3.200188349749077, "Hiatus hernia ": 12.404243996863334, "Hypersomnia ": 10.1666284150812, "Hypoaesthesia ": 2.9323980622877683, "Illness ": 3.0043904013298826, "Immunodeficiency ": 11.728567939078518, "Inflammation ": 3.799330447727375, "Infusion related reaction ": 35.30788970180757, "Lymphocyte count decreased ": 18.01233369918397, "Memory impairment ": 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/79.json @@ -0,0 +1 @@ +{"Acute myocardial infarction ": 9.35550442101695, "Bradycardia ": 3.2330281139724, "Cardiac arrest ": 12.874130494253755, "Cardiac failure ": 2.4778144360344303, "Cardiac tamponade ": 99.2925357550834, "Cardio-respiratory arrest ": 9.684193719005332, "Cardiogenic shock ": 21.47309423000936, "Cerebral haemorrhage ": 6.251988302359264, "Chest pain ": 2.0049694070971675, "Coagulation time abnormal ": 6112.261523717118, "Coagulopathy ": 20.283819701341173, "Coronary artery dissection ": 1089.2542757072365, "Coronary artery occlusion ": 37.35231260250416, "Coronary artery perforation ": 7196.372120109358, "Coronary artery thrombosis ": 731.2447008081293, "Death ": 2.177920083353408, "Device occlusion ": 152.72878465706273, "Device related thrombosis ": 252.83703855717584, "Haematoma ": 7.602528803716543, "Haemoglobin decreased ": 5.936204469293225, "Haemorrhage ": 9.510545799059694, "Haemorrhage 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100644 index 00000000000..b39900a26f0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/790.json @@ -0,0 +1 @@ +{"Fall ": 3.271074885123871, "Gait disturbance ": 3.4849616183587555, "Intentional product use issue ": 7.445990178470172, "Multiple sclerosis ": 38.058270279091005, "Multiple sclerosis relapse ": 29.09856964033237} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/791.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/791.json new file mode 100644 index 00000000000..b7995706300 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/791.json @@ -0,0 +1 @@ +{"Anti factor VIII antibody positive ": 4529.024532274634, "Drug ineffective ": 7.684214562875225, "Factor VIII inhibition ": 1707.5779513017712} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/792.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/792.json new file mode 100644 index 00000000000..bd9f21a4c92 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/792.json @@ -0,0 +1 @@ +{"Abdominal distension ": 3.718576062726355, "Bone pain ": 4.514649864366543, "Cholelithiasis ": 19.996518143655745, "Disease progression ": 2.839871820071082, "Disseminated intravascular coagulation ": 19.71523571605949, "Drug reaction with eosinophilia and systemic symptoms ": 7.935000261638885, "Epistaxis ": 2.7555047985676877, "Heart rate decreased ": 11.257876641843296, "Hyperglycaemia ": 6.794022826848816, "Illness ": 4.5321324450549, "Malignant neoplasm progression ": 6.346768049164015, "Metastases to liver ": 19.263468254725467, "Post procedural haemorrhage ": 40.42174416181631, "Product use in unapproved indication ": 2.309634455269961, "Rectal haemorrhage ": 6.984364082233032, "Sepsis ": 6.38044491014} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/793.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/793.json new file mode 100644 index 00000000000..43e66a0054c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/793.json @@ -0,0 +1 @@ +{"Anaemia ": 2.8867400411180806, "Chronic lymphocytic leukaemia ": 170.2732843630645, "Diffuse large B-cell lymphoma ": 96.02542075337604, "Diffuse large B-cell lymphoma recurrent ": 218.4133132089203, "Malignant neoplasm progression ": 7.042521180092629, "Neutropenia ": 2.618424355129595, "Pneumonia ": 2.2505228850080816, "Product use in unapproved indication ": 15.181705285752845, "Throat irritation ": 12.142701430593592, "Toxicity to various agents ": 3.286302126994183} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/794.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/794.json new file mode 100644 index 00000000000..2cf778e9124 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/794.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.292965435047865, "Abdominal distension ": 2.052415346549608, "Abdominal pain ": 2.953012582476298, "Abdominal pain upper ": 2.7787216174869185, "Abnormal loss of weight ": 9.189783815760324, "Acute coronary syndrome ": 4.000394916872363, "Acute myocardial infarction ": 2.8617991978765023, "Acute respiratory failure ": 2.695192903565324, "Anal incontinence ": 2.206531905684396, "Blood pressure diastolic abnormal ": 13.753948699635435, "COVID-19 pneumonia ": 2.2884836677368563, "Chronic respiratory failure ": 19.23280302137393, "Constipation ": 3.2903745057308997, "Coronavirus infection ": 3.8549080581601096, "Cough ": 2.682697929912185, "Death ": 7.147434911904626, "Decreased appetite ": 6.200385622608918, "Diarrhoea ": 13.028577007205682, "Diarrhoea haemorrhagic ": 2.884805684208494, "Diverticulitis ": 3.2795509670615868, "Dyspepsia ": 3.006162773041564, "Dyspnoea exertional ": 8.314153551343185, "Epistaxis ": 2.2470087561358683, "Faeces discoloured ": 2.76097139749974, "Faeces soft ": 27.11674947633393, "Flatulence ": 5.593547113798278, "Forced vital capacity decreased ": 89.14292732257697, "Gamma-glutamyltransferase increased ": 4.293371678104928, "Gastric haemorrhage ": 2.6180614604235624, "Gastrointestinal disorder ": 5.779469064507282, "Gastrointestinal pain ": 2.742896542182305, "Gastrointestinal perforation ": 4.392510452123849, "Gastrointestinal sounds abnormal ": 4.484790637477156, "General physical health deterioration ": 2.2713233192511337, "Haemoptysis ": 3.524722204336436, "Hepatic cytolysis ": 2.5698406498407995, "Hepatic enzyme increased ": 5.231652055886028, "Hepatotoxicity ": 3.9754868498428086, "Hip fracture ": 3.044727896251443, "Hypertransaminasaemia ": 7.158299680220993, "Hypophagia ": 4.469428165076442, "Hypoxia ": 2.2809805020470924, "Idiopathic pulmonary fibrosis ": 650.3447195237708, "Interstitial lung disease ": 2.848202196193612, "Intestinal perforation ": 4.069453398153047, "Investigation abnormal ": 18.684351061546703, "KL-6 increased ": 15.814963824351024, "Liver disorder ": 2.3109187802046227, "Liver function test abnormal ": 2.7050995841816503, "Liver function test increased ": 9.71141303055552, "Lower gastrointestinal haemorrhage ": 2.404607702312918, "Lung diffusion test decreased ": 39.5815663846807, "Lung disorder ": 4.593783756963166, "Lung neoplasm malignant ": 5.500278878535834, "Lung transplant ": 51.13058623378122, "Myocardial infarction ": 2.170622258264545, "Nausea ": 2.121303412956336, "Nephrotic syndrome ": 2.398954613152664, "Oxygen consumption increased ": 26.952328427651786, "Oxygen saturation decreased ": 7.071504980995843, "Physical deconditioning ": 9.419122685306077, "Pneumomediastinum ": 12.962014744564977, "Pneumonia ": 2.949082973703358, "Pneumothorax ": 12.751779894493763, "Post procedural complication ": 2.691475955140743, "Productive cough ": 7.921496209644519, "Pulmonary arterial hypertension ": 3.181696056288685, "Pulmonary fibrosis ": 10.79908655657334, "Pulmonary function test decreased ": 16.866008493366138, "Pulmonary hypertension ": 8.38786401808802, "Pulseless electrical activity ": 14.659397352398202, "Respiratory disorder ": 2.173575047090299, "Respiratory failure ": 4.068766326553877, "Respiratory rate increased ": 3.1611292400371265, "Right ventricular failure ": 4.051303740074024, "Scleroderma ": 8.986190619908276, "Seasonal allergy ": 3.507581480832375, "Sputum discoloured ": 2.947600543336244, "Taste disorder ": 2.0028583095256924, "Tooth infection ": 3.696739249755713, "Transaminases increased ": 8.834659061321089, "Transient ischaemic attack ": 2.369054124380918, "Varicose vein ": 3.4721469064555444, "Vomiting ": 2.462672681721218, "Weight decreased ": 12.07469519066245} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/795.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/795.json new file mode 100644 index 00000000000..e24fcd5ea27 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/795.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 5.2419048816385, "Abnormal weight gain ": 11.246950159165372, "Abulia ": 5.886206226120309, "Accidental death ": 80.61733219893797, "Accidental exposure to product by child ": 5.823193115990974, "Accidental overdose ": 3.273911711555235, "Acute psychosis ": 5.765437993356041, "Acute pulmonary oedema ": 2.4004492326908715, "Affect lability ": 3.424144708205358, "Affective disorder ": 4.633541349463407, "Aggression ": 6.04988281386844, "Agitated depression ": 36.11741074022127, "Agitation ": 5.860586630882987, "Agitation neonatal ": 9.707724095089349, "Agranulocytosis ": 2.334557891442586, "Akathisia ": 21.53859848925718, "Akinesia ": 6.136929522745733, "Alanine aminotransferase increased ": 2.1849079482094584, "Alcohol withdrawal syndrome ": 15.003346999506974, "Altered state of consciousness ": 3.4109151356141263, "Amimia ": 48.025924027778274, "Ammonia increased ": 2.901280505008553, "Anosognosia ": 11.127151250086804, "Anticholinergic syndrome ": 65.76881218578033, "Antiphospholipid antibodies ": 32.25696391938091, "Antipsychotic drug level below therapeutic ": 3.4954684399884868, "Antipsychotic drug level increased ": 19.266132377911028, "Antisocial behaviour ": 8.959125441339296, "Apallic syndrome ": 6.864923034946712, "Apathy ": 3.939502746445686, "Areflexia ": 3.113231895045645, "Arteriosclerosis coronary artery ": 2.2989359988665967, "Aspartate aminotransferase increased ": 2.1454491163332845, "Asphyxia ": 2.4335233979392616, "Aspiration ": 4.270124471329763, "Ataxia ": 2.7552988641642573, "Atrioventricular block first degree ": 2.317278643333808, "Atrioventricular septal defect ": 13.633059911382356, "Autonomic nervous system imbalance ": 7.107026321384545, "Behaviour disorder ": 3.74630776013136, "Benign ethnic neutropenia ": 268.9572815303201, "Bezoar ": 12.69115397249462, "Bipolar I disorder ": 20.51866285655935, "Bipolar disorder ": 6.2101257248433255, "Blood bicarbonate decreased ": 3.054626961801964, "Blood chloride decreased ": 3.002825638621942, "Blood chloride increased ": 3.0919741061681267, "Blood creatine phosphokinase MB increased ": 3.908728399079709, "Blood creatine phosphokinase increased ": 7.899807788702598, "Blood osmolarity increased ": 9.231411979906357, "Blood prolactin increased ": 29.073941991485032, "Blood sodium increased ": 6.541851133824914, "Blood triglycerides increased ": 4.521105132450023, "Blood urea decreased ": 13.90761467769775, "Blunted affect ": 16.254253827353367, "Body mass index increased ": 8.07268986998991, "Borderline personality disorder ": 11.509861677372, "Bradykinesia ": 20.263084058876075, "Bradyphrenia ": 2.3138872649264988, "Brain death ": 3.165511673955791, "Brain injury ": 3.004951386655479, "Brain oedema ": 2.376411346632072, "Bundle branch block right ": 2.7729175962758785, "Camptocormia ": 84.78663070257144, "Cardiac arrest ": 2.605185644985282, "Cardio-respiratory arrest ": 5.881980776594869, "Cardiomyopathy ": 4.186961524971776, "Catatonia ": 47.71680434909285, "Cerebellar atrophy ": 4.422468660015504, "Cerebral atrophy ": 3.8895803964417466, "Cerebral ischaemia ": 2.0264991344839265, "Chorea ": 4.670603461658708, "Clonus ": 6.949665684448042, "Cognitive disorder ": 3.51444429254314, "Cogwheel rigidity ": 34.11785841693764, "Colitis ischaemic ": 4.194947631464654, "Coma ": 5.460787019478733, "Coma scale abnormal ": 8.067559918326827, "Communication disorder ": 4.92814037139773, "Compartment syndrome ": 4.712936222785347, "Completed suicide ": 9.062449783459076, "Confusional state ": 2.47957690537733, "Consciousness fluctuating ": 9.429362502258442, "Decreased interest ": 3.404417598105121, "Decubitus ulcer ": 2.8332524394686125, "Delirium ": 6.626404500487753, "Delusion ": 14.141258067707325, "Delusion of grandeur ": 18.813203501731092, "Delusion of replacement ": 120.23698780931264, "Dementia with Lewy bodies ": 26.069378498150364, "Depressed level of consciousness ": 4.707869162000302, "Depressive symptom ": 2.476345667833245, "Derealisation ": 2.692353059626565, "Diabetes insipidus ": 3.785527016663176, "Diabetes mellitus ": 3.1691932370526965, "Diabetic ketoacidosis ": 2.634341098214647, "Discoloured vomit ": 30.92079707612087, "Disinhibition ": 5.750037767893161, "Disorganised speech ": 2.486484061739235, "Disorientation ": 2.9804685547471754, "Disturbance in social behaviour ": 4.405441948850473, "Drooling ": 3.4997817277510266, "Drug abuse ": 4.671947589421734, "Drug interaction ": 4.2991842755337215, "Drug level above therapeutic ": 9.74909543278086, "Drug level increased ": 4.030026095105472, "Drug screen positive ": 3.654101336807519, "Drug withdrawal syndrome neonatal ": 3.501615035932806, "Drug-induced liver injury ": 2.3838026552214964, "Dysarthria ": 4.363400018441745, "Dyskinesia ": 6.049791328036221, "Dyslipidaemia ": 4.651356975304616, "Dysphemia ": 2.918834384814183, "Dysphoria ": 2.817686011247777, "Dystonia ": 16.799632656291084, "Electrocardiogram QRS complex prolonged ": 5.405784864839431, "Electrocardiogram QT prolonged ": 7.857470223806124, "Electrocardiogram T wave inversion ": 3.395041870017632, "Electrocardiogram abnormal ": 3.819595401994779, "Electroencephalogram abnormal ": 4.943405819363087, "Embolism venous ": 15.407549221040592, "Encephalitis autoimmune ": 2.396197975952264, "Endotracheal intubation ": 3.365308209875552, "Enuresis ": 2.615079368620928, "Eosinophil count decreased ": 5.101034076783346, "Euphoric mood ": 6.380709884814332, "Excessive eye blinking ": 8.235463546387367, "Extrapyramidal disorder ": 31.59042515538941, "Eye movement disorder ": 2.072099087014061, "Faecaloma ": 6.012244796546263, "Feeling guilty ": 13.111634603880336, "Flat affect ": 4.068530612828039, "Flight of ideas ": 30.211421559429255, "Fluid intake reduced ": 2.7311109480522857, "Foaming at mouth ": 2.260484008020889, "Foetal exposure timing unspecified ": 4.034864742812943, "Food craving ": 4.02002232787715, "Frustration tolerance decreased ": 4.37571448607221, "Galactorrhoea ": 8.440105828096973, "Gastrointestinal hypomotility ": 10.899062263753558, "Gastrointestinal necrosis ": 2.9361393491811647, "Gastrointestinal sounds abnormal ": 5.160806530250731, "Gaze palsy ": 3.1894547602953405, "Generalised anxiety disorder ": 5.024530229898881, "Generalised tonic-clonic seizure ": 2.8720648107859748, "Gestational diabetes ": 9.594948023581908, "Glucose urine present ": 4.372717211170411, "Grandiosity ": 19.55065459329453, "Granulocytopenia ": 4.1550398468896415, "Gynaecomastia ": 2.882632510130985, "Haematocrit increased ": 2.2046835363884574, "Haemodynamic instability ": 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9.635199522821653, "Hypertonia ": 7.773807210478494, "Hypertriglyceridaemia ": 5.820701599233047, "Hyperuricaemia ": 3.793125129361596, "Hypoalbuminaemia ": 2.238354369643893, "Hypocalcaemia ": 2.199427413226372, "Hypomania ": 7.622981146320928, "Hyponatraemia ": 2.579177164353873, "Hypophagia ": 3.0593361504695524, "Hyporeflexia ": 2.223539220828348, "Hypothermia ": 7.957704254517482, "Hypotonia neonatal ": 5.8236503102731785, "Hypoventilation ": 4.83560549183394, "Hypoxic-ischaemic encephalopathy ": 3.42564366408953, "Ileus paralytic ": 8.155465312920613, "Illusion ": 2.8556700212093324, "Immobile ": 2.45125955451049, "Impulsive behaviour ": 8.136177134481038, "Inappropriate antidiuretic hormone secretion ": 4.98296706928932, "Incoherent ": 2.9484518453631647, "Incontinence ": 2.407502371630319, "Increased appetite ": 9.939609644550854, "Increased bronchial secretion ": 3.335935127303889, "Intentional overdose ": 7.554817683992456, "Intentional product misuse ": 2.1397681211237107, "Intentional self-injury ": 7.8334947877281875, "Intestinal obstruction ": 2.750556602696021, "Intestinal pseudo-obstruction ": 11.010588333359712, "Irritability ": 2.665301663549413, "Judgement impaired ": 7.769870232645914, "Ketonuria ": 4.960717835746749, "Labelled drug-drug interaction issue ": 6.417893443804156, "Labelled drug-food interaction medication error ": 32.27977575299081, "Labile blood pressure ": 4.762087110553849, "Large intestinal obstruction ": 10.07359796062237, "Leukocyte adhesion deficiency ": 549.0021310917658, "Leukocytosis ": 4.959125689385736, "Leukopenia ": 3.029217321782993, "Libido increased ": 5.217943264426953, "Lipids increased ": 4.002983003452871, "Liver function test abnormal ": 2.0787003756372027, "Logorrhoea ": 3.6690582505569904, "Long QT syndrome ": 8.324889743984125, "Lymphocyte count decreased ": 4.587936696652833, "Major depression ": 5.48732768183777, "Mania ": 10.67150246896983, "Megacolon ": 9.863359753195429, "Meige's syndrome ": 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2.40461590457212, "Neutrophil count increased ": 6.995768602379992, "Neutrophilia ": 3.442482096648433, "Normal newborn ": 2.87799180720436, "Obesity ": 5.668834166547385, "Obsessive thoughts ": 6.924538703314073, "Obsessive-compulsive disorder ": 11.01658567352957, "Obsessive-compulsive symptom ": 47.47952688971287, "Oculogyric crisis ": 25.772206569072985, "Opisthotonus ": 4.452592573666275, "Oromandibular dystonia ": 13.729124271715389, "Orthostatic hypotension ": 2.933419926990098, "Ovarian cancer ": 2.6596420955391373, "Overdose ": 4.315073173179077, "Overweight ": 5.306813913390497, "Painful erection ": 25.293361852981807, "Pancreatic neuroendocrine tumour metastatic ": 11.680702112028191, "Pancreatitis haemorrhagic ": 10.231150068199211, "Pancreatitis necrotising ": 5.879915436039491, "Paranoia ": 5.36353819543423, "Parkinsonian gait ": 10.39507516048998, "Parkinsonian rest tremor ": 19.91414013769362, "Parkinsonism ": 25.270518300614523, "Paternal exposure timing unspecified ": 10.93077297010494, "Persecutory delusion ": 19.83305203951076, "Personality disorder ": 3.244798425416371, "Phagophobia ": 205.8791551113204, "Phobia ": 7.324603873684357, "Pituitary tumour benign ": 5.49796598715079, "Pleurothotonus ": 69.58405259296852, "Pneumonia aspiration ": 6.485847307012103, "Pneumonitis aspiration ": 9.08012560922131, "Poisoning ": 7.454475427875071, "Poisoning deliberate ": 9.653937600898152, "Polydipsia ": 7.217015639482775, "Polydipsia psychogenic ": 26.074045327665026, "Polyuria ": 2.2375607622588274, "Post-injection delirium sedation syndrome ": 20.932082239866972, "Post-traumatic stress disorder ": 2.308234006745232, "Postoperative ileus ": 28.413322761654747, "Posture abnormal ": 13.451442547437908, "Prescribed overdose ": 6.759460124181447, "Pressure of speech ": 22.70129626412294, "Priapism ": 26.895689545416836, "Product communication issue ": 14.089062967658434, "Product monitoring error ": 8.01080142083515, "Product substitution issue ": 2.278071779154693, "Progressive supranuclear palsy ": 41.07468947631209, "Protrusion tongue ": 11.507858120138104, "Psychiatric decompensation ": 14.85222806556086, "Psychiatric symptom ": 5.079072930928464, "Psychomotor hyperactivity ": 5.808412534572094, "Psychomotor retardation ": 12.185465414783588, "Psychotic behaviour ": 10.31930889480686, "Psychotic disorder ": 10.875990363254797, "Psychotic symptom ": 39.66808173952492, "Pulmonary congestion ": 6.12920825377303, "Pulmonary embolism ": 2.3233143192781363, "Pulse absent ": 5.014710812951462, "Pupil fixed ": 3.603821993950385, "Quadriparesis ": 3.937688202581549, "Rebound effect ": 6.256105129507945, "Rebound psychosis ": 106.88922511972568, "Red blood cell count increased ": 3.3472621968584666, "Reduced facial expression ": 11.51494444522018, "Respiratory acidosis ": 3.5412625369690804, "Respiratory arrest ": 3.744397413722359, "Respiratory depression ": 4.45453561669157, "Respiratory distress ": 2.3129881330409603, "Resting 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3.4459214675349013, "Snoring ": 2.157603759288647, "Social avoidant behaviour ": 5.602915092644413, "Somatic delusion ": 79.8906018459257, "Somatic symptom disorder ": 2.7480651906108675, "Somnambulism ": 5.7574073115956, "Somnolence ": 3.6051522537141913, "Sopor ": 6.3811161769568, "Spasmodic dysphonia ": 62.15194642266471, "Speech disorder ": 2.855620406661849, "Stenosis ": 5.312404302100536, "Stupor ": 3.687672587905474, "Substance-induced psychotic disorder ": 22.212046276659617, "Sudden cardiac death ": 14.035715310762845, "Sudden death ": 3.5164558949664677, "Suicidal behaviour ": 3.7922439842708897, "Suicidal ideation ": 2.6097991421378803, "Suicide attempt ": 5.049573598934948, "Suspected suicide ": 9.95785460917635, "Suspiciousness ": 25.30100663086496, "Systolic dysfunction ": 4.341338407462684, "Tachycardia ": 2.515647125976313, "Tachyphrenia ": 2.6401312264251247, "Tachypnoea ": 3.702502457495119, "Talipes ": 2.440000705024947, "Tardive dyskinesia ": 35.111911796354974, "Tension ": 2.923917671602552, "Therapy non-responder ": 2.181324211627683, "Thinking abnormal ": 4.254875081280143, "Tobacco interaction ": 112.26635843984668, "Tongue biting ": 3.2966425279324736, "Tonic convulsion ": 2.711712706108903, "Torsade de pointes ": 5.666907076393908, "Torticollis ": 11.14843886135258, "Toxicity to various agents ": 8.097498045037192, "Transaminases increased ": 2.776748634753388, "Treatment noncompliance ": 6.938691579312748, "Tremor ": 2.26519675361044, "Troponin T increased ": 3.7262373177769006, "Troponin increased ": 4.913117012979564, "Type 1 diabetes mellitus ": 2.2965221425861517, "Type 2 diabetes mellitus ": 3.0062617417180237, "Unresponsive to stimuli ": 4.835882599316331, "Urinary hesitation ": 2.512166259223931, "Urinary incontinence ": 2.2507077602968293, "Urinary retention ": 2.807135647745135, "Vascular neoplasm ": 111.0995887837676, "Ventricular arrhythmia ": 4.67490220093029, "Violence-related symptom ": 7.465011213617355, "Water intoxication ": 12.226337145241295, "Weight increased ": 7.9049412818814, "White blood cell count increased ": 3.8552802304920464, "Withdrawal syndrome ": 2.71668153838363, "Wrong patient ": 17.458444581781713, "Wrong patient received product ": 11.013083263651046, "Xanthoma ": 34.39158731469135} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/796.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/796.json new file mode 100644 index 00000000000..f2a35bce6b1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/796.json @@ -0,0 +1 @@ +{"Acute myeloid leukaemia ": 18.25791755637005, "Alanine aminotransferase increased ": 2.6815610492767963, "Anaemia ": 23.27578665585569, "Asthenia ": 2.6356532768473744, "Carbohydrate antigen 125 increased ": 103.72063657122432, "Disease progression ": 3.049097229638003, "Drug resistance ": 8.319354230066157, "Dyspnoea exertional ": 2.6853782465150915, "Haematotoxicity ": 31.78129426960385, "Haemoglobin abnormal ": 28.3281796527241, "Haemoglobin decreased ": 5.354272763753961, "Leukopenia ": 7.88560598918799, "Lymphopenia ": 14.303938738756528, "Malignant neoplasm progression ": 20.91696188034176, "Metastases to bone ": 14.81828111570877, "Metastases to central nervous system ": 13.157402366366735, "Metastases to liver ": 20.452640339256494, "Metastases to lung ": 14.223318352326697, "Metastases to lymph nodes ": 16.58734584391089, "Metastases to pelvis ": 142.41297073437656, "Metastases to spine ": 41.00453127641667, "Myelodysplastic syndrome ": 84.84470807194162, "Myelosuppression ": 10.070589398960326, "Nausea ": 2.379809113658327, "Neutropenia ": 6.662389274626959, "Off label use ": 3.261221889821022, "Ovarian cancer recurrent ": 228.7139975240651, "Pancytopenia ": 5.098888063138287, "Platelet count decreased ": 2.806226231860063, "Pneumonitis ": 6.580111946942954, "Product use in unapproved indication ": 3.247397749063283, "Prostatic specific antigen increased ": 9.581649539149394, "Red blood cell count decreased ": 5.361850044180246, "Thrombocytopenia ": 8.613044668658455, "White blood cell count decreased ": 3.089787173753777} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/797.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/797.json new file mode 100644 index 00000000000..bcb0c101a30 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/797.json @@ -0,0 +1 @@ +{"Alopecia areata ": 508.9692650940183, "Drug-induced liver injury ": 41.10149991505892, "Hepatic function abnormal ": 20.77731600369258, "Pancytopenia ": 10.366808009349796, "Urticaria ": 3.071350674460613} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/798.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/798.json new file mode 100644 index 00000000000..66d1b95c7ae --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/798.json @@ -0,0 +1 @@ +{"Herpes zoster ": 6.555151153543076} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/799.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/799.json new file mode 100644 index 00000000000..635a946f27d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/799.json @@ -0,0 +1 @@ +{"Acute hepatic failure ": 8.180619852071928, "Alanine aminotransferase increased ": 2.2722500177165923, "Anaemia ": 4.7249467804610585, "Anuria ": 3.2301788820576784, "Ascites ": 11.281419352584866, "Aspartate aminotransferase increased ": 2.670807948973907, "Blood albumin decreased ": 9.268549993358006, "Blood alkaline phosphatase increased ": 2.070767466038057, "Blood bilirubin abnormal ": 54.23594779242484, "Blood bilirubin increased ": 31.52470415886541, "Cheilitis ": 17.171008689501928, "Dermatitis bullous ": 4.730784363599918, "Drug ineffective ": 6.509786942443665, "Eczema ": 2.2986677950224768, "Encephalopathy ": 3.251525412656104, "Haemoglobin decreased ": 3.2054666526803826, "Hepatic cancer ": 5.621424277234415, "Hepatic cirrhosis ": 12.51313699003402, "Hepatic encephalopathy ": 20.83149632821512, "Hepatic failure ": 18.711822179841597, "Hepatic function abnormal ": 2.22619695749173, "Hepatic lesion ": 8.933914118091076, "Hepatitis C ": 119.83930948018384, "Hepatitis C RNA ": 530.1486413459464, "Hepatitis C RNA increased ": 68.92528886197735, "Hepatitis C virus test positive ": 43.4134411319507, "Hepatitis acute ": 4.657834937980569, "Hepatocellular carcinoma ": 20.56345777099131, "Hepatorenal syndrome ": 50.17000056017976, "Hyperbilirubinaemia ": 61.468550347275226, "Irritability ": 2.3920423296030413, "Jaundice ": 14.887130439995582, "Lip oedema ": 3.1115354828713917, "Liver transplant ": 19.22634199254209, "Lung adenocarcinoma ": 28.043911661689865, "Lymphopenia ": 4.572777251010968, "Multiple organ dysfunction syndrome ": 2.102722631470594, "Off label use ": 9.880882689573005, "Photosensitivity reaction ": 61.43671189451053, "Portal vein thrombosis ": 16.432735008781343, "Product quality issue ": 13.823559289434725, "Pruritus ": 2.428640077078519, "Sinus bradycardia ": 7.737885858959147, "Skin exfoliation ": 2.2929879370282253, "Solar dermatitis ": 83.46544440553645, "Sudden death ": 5.140131934387264, "Sunburn ": 74.22520496059998, "Therapy non-responder ": 2.743193873313693, "Toxic skin eruption ": 4.347186937978319, "Transaminases increased ": 4.391375733580238, "Transplant rejection ": 10.127033979340144, "Treatment failure ": 8.773391275663554, "Treatment noncompliance ": 2.5238475424439133, "Viral load increased ": 40.2837904915344, "Viral mutation identified ": 12.719277201096364, "Virologic failure ": 12.010557119057042, "White blood cell count increased ": 2.056386271795356} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/8.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/8.json new file mode 100644 index 00000000000..967fb08034c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/8.json @@ -0,0 +1 @@ +{"Acute coronary syndrome ": 98.12491820156411, "Acute kidney injury ": 7.839449914233081, "Disease progression ": 19.19293996840077, "Drug interaction ": 2.729721991634752, "Hepatotoxicity ": 27.09826907391346, "Hormone-refractory prostate cancer ": 497.7202871067497, "Hypokalaemia ": 9.00798235062046, "Malignant neoplasm progression ": 9.80531146295762, "Prostate cancer metastatic ": 758.3802573695656, "Rhabdomyolysis ": 27.94208360278053} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/80.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/80.json new file mode 100644 index 00000000000..1be96b0252d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/80.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 3.6412271830490575, "Anaemia ": 2.371752324636192, "Bacteraemia ": 27.023867156305663, "Bronchopulmonary aspergillosis ": 62.51483531482919, "COVID-19 pneumonia ": 38.77825477129275, "Candida infection ": 44.95447980235934, "Cellulitis ": 6.978286938413132, "Condition aggravated ": 7.618217268206459, "Drug ineffective ": 3.271138709902172, "Drug resistance ": 32.48423929122619, "Eye infection fungal ": 1305.0195962222592, "Haemodynamic instability ": 68.80844849758704, "Intraocular pressure test ": 1512.9765152147052, "Intraocular pressure test abnormal ": 697.7867588970669, "Klebsiella infection ": 74.67587544324111, "Multi-organ disorder ": 149.71178760117215, "Multiple organ dysfunction syndrome ": 32.04139621301433, "Neutropenia ": 8.283197941217677, "Pancytopenia ": 3.9428006652885976, "Pathogen resistance ": 41.06116395601374, "Peritonitis ": 33.843766951424854, "Renal impairment ": 3.5051184866331315, "Respiratory failure ": 4.206649519313346, "Scedosporium infection ": 1236.0227957260513, "Sepsis ": 7.635830207299897, "Septic shock ": 22.45631767990235, "Thrombocytopenia ": 2.7263637091714057} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/800.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/800.json new file mode 100644 index 00000000000..0feeb9c4621 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/800.json @@ -0,0 +1 @@ +{"Accident ": 3.056239258440144, "Allergy to animal ": 59.334493209915, "Allergy to chemicals ": 28.60604262039675, "Allergy to metals ": 10.359655157342216, "Allergy to plants ": 169.27800812603675, "Alpha 1 globulin increased ": 120.3782051321448, "Alpha 2 globulin increased ": 120.3782051321448, "Alveolar osteitis ": 318.7836480658726, "Anaphylactic reaction ": 2.5126463308115072, "Aneurysm ": 4.402838179403826, "Angioedema ": 2.38977781356213, "Animal scratch ": 185.6870593965517, "Aortic aneurysm ": 5.654030358498327, "Aphonia ": 3.3723739464537097, "Arthropod bite ": 4.1974747059302215, "Asthma ": 20.348422047350333, "Asthmatic crisis ": 3.3839733280445805, "Basophil percentage decreased ": 196.94243336374657, "Biliary colic ": 4.819398578611437, "Bladder pain ": 18.334293330578927, "Blood immunoglobulin E increased ": 30.152529532280926, "Blood iron decreased ": 18.139878914935984, "Blood pressure diastolic decreased ": 7.144644246218551, "Blood pressure diastolic increased ": 6.992976739592857, "Blood pressure increased ": 4.021068855045272, "Blood pressure systolic increased ": 31.539085377525303, "Blood test abnormal ": 3.872188813681152, "Blood urine present ": 4.195451152866994, "Body temperature 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3.4153061409529117, "Incorrect dose administered ": 2.112311293662732, "Increased bronchial secretion ": 8.76056365018181, "Increased upper airway secretion ": 4.437324169530553, "Influenza ": 2.817614568065777, "Injection site bruising ": 6.12299501848918, "Injection site haemorrhage ": 2.417497171054172, "Joint dislocation ": 4.119786123383254, "Lacrimation increased ": 2.08615339088857, "Laryngitis ": 4.808069788968769, "Ligament rupture ": 9.482026379166994, "Ligament sprain ": 7.911694007255219, "Loss of personal independence in daily activities ": 2.7422822870531185, "Lower respiratory tract infection ": 6.16530331518118, "Lung consolidation ": 8.00091386457747, "Lung diffusion test decreased ": 61.35249931651309, "Lung disorder ": 4.268430244772706, "Lymphocyte percentage decreased ": 10.779133786317669, "Mast cell activation syndrome ": 7.42692119857508, "Mastocytosis ": 24.92111361971912, "Mechanical urticaria ": 4.674798296271496, "Middle insomnia ": 25.712367272315667, 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"Pulmonary congestion ": 2.3897913851600987, "Pulmonary function test decreased ": 7.83653574971045, "Pulmonary thrombosis ": 6.218314566471951, "Pyelonephritis ": 2.136523295454161, "Quality of life decreased ": 2.653036056217251, "Renal neoplasm ": 13.810943766533995, "Respiration abnormal ": 2.9662403606150654, "Respiratory disorder ": 3.536565114041612, "Respiratory rate decreased ": 4.997827755906314, "Respiratory rate increased ": 7.518790513776855, "Respiratory tract congestion ": 20.169682576198927, "Respiratory tract infection ": 21.58096657896734, "Respiratory tract infection fungal ": 27.6704034917253, "Restrictive pulmonary disease ": 12.29904324609998, "Rhinorrhoea ": 3.647646075692884, "Rubber sensitivity ": 67.94600535346616, "Scratch ": 11.26370358883795, "Seasonal allergy ": 9.120068804313505, "Secretion discharge ": 8.034700169657185, "Sensitivity to weather change ": 69.57827674274456, "Sinus congestion ": 6.591708898377648, "Sinus disorder ": 5.591133500570365, 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end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/810.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/810.json new file mode 100644 index 00000000000..061fa678095 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/810.json @@ -0,0 +1 @@ +{"Addison's disease ": 10.721286382533403, "Adrenal disorder ": 24.177262636318197, "Adrenal insufficiency ": 89.26868147766206, "Adrenocortical insufficiency acute ": 27.73348853346601, "Adrenocorticotropic hormone deficiency ": 314.68175790908253, "Alanine aminotransferase increased ": 2.1454070062029933, "Amylase increased ": 4.95806308725641, "Aspartate aminotransferase increased ": 2.3023644968115566, "Autoimmune colitis ": 95.6025489184596, "Autoimmune dermatitis ": 78.15567788188058, "Autoimmune haemolytic anaemia ": 4.155068233475303, "Autoimmune hepatitis ": 26.58098832801254, "Autoimmune nephritis ": 37.69317824285383, "Autoimmune pancreatitis ": 41.17946796875452, "Autoimmune thyroiditis ": 10.513798600314455, "Blood corticotrophin decreased ": 62.27091645409207, "Blood creatine phosphokinase increased ": 2.1419227580911206, "Blood thyroid stimulating hormone abnormal ": 19.05353379167592, "Blood thyroid stimulating hormone decreased ": 10.746159253462151, "Blood thyroid stimulating hormone increased ": 2.940238192872663, "Brain oedema ": 2.2233192991500506, "Bronchopulmonary aspergillosis ": 2.852820722390136, "C-reactive protein increased ": 2.6225406050329614, "Central hypothyroidism ": 26.05312368843499, "Cholangitis ": 9.07120859395352, "Cholangitis sclerosing ": 18.55649613057516, "Cholecystitis ": 2.9151497116995624, "Cholestasis ": 2.398980272128844, "Chronic gastritis ": 3.407306997076868, "Colitis ": 37.01876210175181, "Colitis microscopic ": 5.047996020770578, "Coronavirus infection ": 3.072776966096285, "Cortisol decreased ": 17.502826210074264, "Cytokine release syndrome ": 11.937667423042948, "Cytomegalovirus enterocolitis ": 13.245436749455424, "Decreased appetite ": 2.909941317599181, "Dermatitis ": 4.015389865251529, "Dermatitis psoriasiform ": 6.18950933479755, "Diabetic ketoacidosis ": 3.257024816621925, "Diarrhoea ": 2.047321335303416, "Disseminated intravascular coagulation ": 6.33840348610658, "Drug eruption ": 5.390890298927222, "Drug-induced liver injury ": 4.198966253786695, "Duodenal ulcer ": 2.243668147278874, "Duodenitis ": 8.178438769507647, "Dyslalia ": 5.147577799946268, "Encephalitis ": 10.964496760472093, "Encephalitis autoimmune ": 13.15738855375916, "Endocrine disorder ": 19.05909630543023, "Enteritis ": 6.857863249905643, "Enterocolitis ": 30.508664701013632, "Eosinophil count increased ": 4.270700288981342, "Erythema multiforme ": 7.386131501351977, "Eyelid ptosis ": 5.760881421450782, "Febrile neutropenia ": 2.621422649534555, "Fulminant type 1 diabetes mellitus ": 176.56552251434485, "Gastritis ": 2.026011428351472, "Gastrointestinal perforation ": 4.875137917493226, "Glucocorticoid deficiency ": 27.08891849697116, "Graves' disease ": 3.2690845328398903, "Guillain-Barre syndrome ": 3.6578166407226256, "Haemophagocytic lymphohistiocytosis ": 16.57668238767877, "Hair colour changes ": 2.031473398392185, "Hepatic cytolysis ": 4.644697985158562, "Hepatic failure ": 2.0937343647489457, "Hepatic function abnormal ": 8.778091511202947, "Hepatitis ": 9.805443579049854, "Hepatitis acute ": 2.721252679289698, "Hepatitis fulminant ": 4.283665611637545, "Hepatotoxicity ": 3.769746093408006, "Hypercalcaemia ": 2.2228626430324225, "Hyperlipasaemia ": 10.321826929736323, "Hyperthyroidism ": 16.879856701432683, "Hypertransaminasaemia ": 2.152801648897868, "Hypophysitis ": 166.2949415065339, "Hypopituitarism ": 224.7886056633029, "Hypothalamo-pituitary disorder ": 61.05255206910652, "Hypothyroidism ": 19.828938271863997, "Immune thrombocytopenia ": 3.2852145534871084, "Immune-mediated adrenal insufficiency ": 233.0824053732555, "Immune-mediated adverse reaction ": 111.99013875702488, "Immune-mediated arthritis ": 91.7969739074402, "Immune-mediated cholangitis ": 70.12170709435715, "Immune-mediated dermatitis ": 385.580392753696, "Immune-mediated encephalitis ": 68.50200807486466, "Immune-mediated endocrinopathy ": 135.6052457121074, "Immune-mediated enterocolitis ": 153.57751843105626, "Immune-mediated gastritis ": 80.50611893721674, "Immune-mediated hepatic disorder ": 206.16830038711043, "Immune-mediated hepatitis ": 99.53363435730144, "Immune-mediated hyperthyroidism ": 59.723152833924566, "Immune-mediated hypophysitis ": 136.43005773823856, "Immune-mediated hypothyroidism ": 55.93186619878118, "Immune-mediated lung disease ": 152.35088760516322, "Immune-mediated myasthenia gravis ": 37.014866421035, "Immune-mediated myocarditis ": 71.98375210372812, "Immune-mediated myositis ": 53.16995419712262, "Immune-mediated nephritis ": 108.7827885815122, "Immune-mediated neuropathy ": 37.32379813315822, "Immune-mediated 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3.940960003961727, "Metastases to central nervous system ": 13.022718873683932, "Metastases to liver ": 3.0259874143756504, "Metastases to lung ": 3.818139964867101, "Metastases to lymph nodes ": 4.581561098716215, "Metastases to meninges ": 5.882507387465225, "Metastases to spine ": 6.397980894324145, "Metastatic malignant melanoma ": 3.885011201384616, "Myasthenia gravis ": 22.258222480237016, "Myasthenic syndrome ": 9.244769872030815, "Myocarditis ": 6.062662293770092, "Myositis ": 25.150991347116992, "Nephritis ": 13.70680988880464, "Neuropathy peripheral ": 2.7190084123034666, "Neutrophil count decreased ": 3.676145429187547, "Non-small cell lung cancer ": 430.24269236953, "Oesophagitis ": 2.219618530629032, "Organising pneumonia ": 12.062849410281848, "Pancreatic enzymes increased ": 7.751427497641741, "Pemphigoid ": 4.0324965854222174, "Performance status decreased ": 3.0128219635834146, "Peripheral sensory neuropathy ": 4.0890285886855136, "Peritonitis ": 2.603082735384791, "Physical deconditioning ": 3.407527251903232, "Pituitary enlargement ": 66.88881843522914, "Platelet count decreased ": 2.11562675035154, "Pleural effusion ": 2.898203566072025, "Pneumocystis jirovecii pneumonia ": 3.897909439326853, "Pneumonia aspiration ": 3.1114679618671586, "Pneumonia bacterial ": 7.333087599237727, "Pneumonitis ": 22.54156935062784, "Polyarthritis ": 3.054261960266129, "Polymyalgia rheumatica ": 7.063942355122454, "Polymyositis ": 9.135383838466224, "Prescribed overdose ": 4.195065923211207, "Prescribed underdose ": 4.590715224437839, "Primary adrenal insufficiency ": 35.38583373398441, "Primary hypothyroidism ": 32.870005717940174, "Pulmonary toxicity ": 15.986156831300322, "Radiation pneumonitis ": 32.73041213859531, "Rash ": 2.518404743878045, "Rash maculo-papular ": 2.797687070726397, "Renal disorder ": 2.858053983501152, "Renal impairment ": 2.1334675891689945, "Sarcoidosis ": 3.400919556746724, "Secondary adrenocortical insufficiency ": 214.4315939123931, "Sialoadenitis ": 10.437767186324118, "Silent thyroiditis ": 185.3268309983824, "Sjogren's syndrome ": 3.701618463095721, "Skin disorder ": 7.958009716743746, "Skin toxicity ": 5.206369224972339, "Steroid diabetes ": 7.85353687757981, "Stevens-Johnson syndrome ": 2.238393996782843, "Thrombophlebitis migrans ": 42.0414189899959, "Thyroid disorder ": 13.751972503811968, "Thyroiditis ": 65.88600664414933, "Thyroiditis subacute ": 7.0407337600354944, "Thyrotoxic crisis ": 12.941417456050493, "Toxic epidermal necrolysis ": 2.503009088371614, "Troponin increased ": 2.364477633319907, "Tubulointerstitial nephritis ": 9.04539935680851, "Tumour haemorrhage ": 7.962916417110066, "Tumour lysis syndrome ": 4.7530033151256585, "Tumour pseudoprogression ": 62.74309221286461, "Type 1 diabetes mellitus ": 21.305147466049306, "Uveitis ": 7.802749831210593, "Vitiligo ": 11.99276302293395, "Vogt-Koyanagi-Harada disease ": 39.36864820526257} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/811.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/811.json new file mode 100644 index 00000000000..53f056e6414 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/811.json @@ -0,0 +1 @@ +{"Drug abuse ": 90.323352896149} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/812.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/812.json new file mode 100644 index 00000000000..87cc0a4edee --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/812.json @@ -0,0 +1 @@ +{"Drug withdrawal syndrome neonatal ": 140.61201824392026, "Exposure via breast milk ": 155.96923786553293, "Foetal exposure during pregnancy ": 29.85030895051288, "Premature baby ": 39.337907723587456} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/813.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/813.json new file mode 100644 index 00000000000..8c340a7c2a9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/813.json @@ -0,0 +1 @@ +{"Cardio-respiratory arrest ": 150.16074822092176, "Completed suicide ": 119.96856128627208, "Death ": 16.92783660823521, "Drug abuse ": 43.20457782376957, "Respiratory arrest ": 54.78702525440836, "Toxicity to various agents ": 19.32159908955936} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/814.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/814.json new file mode 100644 index 00000000000..9c98d09db83 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/814.json @@ -0,0 +1 @@ +{"Accidental overdose ": 16.81550769169097, "Cardio-respiratory arrest ": 12.917513539631653, "Completed suicide ": 13.00993482950356, "Death ": 2.390661946630833, "Drug abuse ": 32.69048150657904, "Drug dependence ": 30.465534988836197, "Drug screen positive ": 169.0674731848615, "Drug withdrawal syndrome ": 27.80155307735634, "Drug withdrawal syndrome neonatal ": 121.97395366582086, "Exposure via breast milk ": 51.87075023362419, "Foetal exposure during pregnancy ": 14.90641647128799, "Intentional overdose ": 7.009035091167111, "Jaundice neonatal ": 117.36398677284554, "Loss of consciousness ": 2.408752465899624, "Maternal exposure during pregnancy ": 3.468688777077636, "Overdose ": 14.344372271990986, "Product preparation issue ": 72.06738655976147, "Product use issue ": 3.147240815027134, "Somnolence ": 2.160562168160004, "Substance abuse ": 107.88791336990845, "Toxicity to various agents ": 11.557335086071468} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/815.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/815.json new file mode 100644 index 00000000000..bd611fbe1ac --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/815.json @@ -0,0 +1 @@ +{"Abdominal cavity drainage ": 58.94025901768779, "Abdominal distension ": 2.411093440593049, "Acute respiratory failure ": 6.627407599890486, "Adverse event ": 2.327514727965767, "Anaemia ": 2.272610108949878, "Angioplasty ": 6.684156862468332, "Aortic stenosis ": 2.2939467252497585, "Appendicectomy ": 3.6138740843140384, "Application site irritation ": 2.91534735939021, "Ascites ": 4.271538195890879, "Aspiration pleural cavity ": 24.128492591423804, "Atrial flutter ": 6.172755912901156, "Atrial septal defect repair ": 75.08161798233901, "Atrial tachycardia ": 2.2471425237514016, "Bacteraemia ": 3.0465467580142147, "Biopsy lung ": 27.363848627874397, "Blood culture negative ": 79.30190455036674, "Blood culture positive ": 17.568811855734396, "Blood iron decreased ": 6.606844225701386, "Blood magnesium decreased ": 3.040778531316962, "Blood potassium decreased ": 3.3082934855811588, "Brain natriuretic peptide increased ": 18.82167604106816, "Brain operation ": 4.88957517049012, "Bronchitis ": 2.846184472045227, "Cardiac ablation ": 11.329016963963122, "Cardiac failure ": 5.412022013307429, "Cardiac failure acute ": 3.359262120792448, "Cardiac failure congestive ": 4.206451872560103, "Cardiac failure high output ": 42.57542337612482, "Cardiac operation ": 9.174033394060451, "Cardiac output increased ": 52.08328124333962, "Cardiac pacemaker insertion ": 7.80984836768759, "Cardiopulmonary failure ": 2.2315585711772985, "Cardiovascular insufficiency ": 2.3552956199796875, "Cardioversion ": 6.732114424865575, "Catheter management ": 215.6054822398508, "Catheter placement ": 51.99438268895771, "Catheter removal ": 45.30606075588232, "Catheter site discharge ": 87.15336672724418, "Catheter site discolouration ": 158.12701944966307, "Catheter site erythema ": 88.63810958396907, "Catheter site haemorrhage ": 34.06766858394086, "Catheter site infection ": 66.03319479758315, "Catheter site irritation ": 136.5100199846976, "Catheter site pain ": 66.7711346235791, "Catheter site pruritus ": 152.28657713147533, "Catheter site rash ": 94.49781077549986, "Catheter site related reaction ": 29.90964209968053, "Catheter site swelling ": 61.04922292827579, "Catheterisation cardiac ": 28.22678027353397, "Catheterisation cardiac abnormal ": 32.37743745352398, "Cellulitis ": 2.3842422031615835, "Central venous catheterisation ": 20.51310157002341, "Chemotherapy ": 8.046396699684333, "Chest injury ": 4.975825637585127, "Cholecystectomy ": 3.4760526481695693, "Chronic obstructive pulmonary disease ": 3.2138893862480225, "Chronic respiratory failure ": 10.753568419610849, "Clostridium difficile infection ": 3.1238109779995007, "Complication associated with device ": 17.73794551162015, "Concomitant disease aggravated ": 16.37921211863474, "Concomitant disease progression ": 8.339735487176707, "Condition aggravated ": 3.733253601802327, "Congestive hepatopathy ": 11.679755674874226, "Cor pulmonale ": 8.722431909006533, "Death ": 7.382741041761854, "Dependence on oxygen therapy ": 17.24145250144739, "Dermatitis contact ": 5.437985883156154, "Device alarm issue ": 92.04116868389067, "Device breakage ": 13.271947843482458, "Device delivery system issue ": 4.329066948947553, "Device dislocation ": 38.55384531699643, "Device infusion issue ": 18.77176855363161, "Device issue ": 3.191988160904049, "Device leakage ": 21.341079510863743, "Device malfunction ": 2.925824197975192, "Device occlusion ": 9.98034018169426, "Device physical property issue ": 10.189654006060865, "Device related infection ": 15.88712741232774, "Device related sepsis ": 16.412946276396884, "Dialysis ": 15.951529258930387, "Diastolic dysfunction ": 2.066998286045499, "Disease complication ": 18.527501521369302, "Disease progression ": 4.781999671438772, "Dizziness postural ": 2.294030732177548, "Dyspnoea ": 3.594025366506276, "Dyspnoea at rest ": 9.182742724084338, "Dyspnoea exertional ": 9.887235955672486, "Emergency care ": 15.424324189258108, "Endarterectomy ": 55.20156363860814, "Endotracheal intubation ": 4.859550526111471, "Exercise tolerance decreased ": 2.0817930383592755, "Eye operation ": 2.9027119802160875, "Fall ": 2.109423885125416, "Fluid retention ": 27.254934958004824, "Flushing ": 3.906152391992839, "Gallbladder disorder ": 2.1534850725685084, "Gastroenteritis viral ": 3.641284591439321, "Gastrointestinal tube insertion ": 3.6347252609911336, "Generalised oedema ": 2.2570327864732005, "Haematocrit decreased ": 3.691477820664484, "Haemodialysis ": 4.524268557556765, "Haemoglobin decreased ": 3.5894246287493665, "Haemoptysis ": 3.142504543574226, "Head injury ": 2.1011970579048507, "Heart and lung transplant ": 116.41666058635778, "Heart transplant ": 15.5823138595535, "Hepatic cirrhosis ": 2.2101121475318863, "Hepatic enzyme abnormal ": 2.013816510584633, "Hernia repair ": 6.401501456095998, "Hip fracture ": 2.8809232767830277, "Hip surgery ": 3.2827659714076862, "Hospice care ": 16.391617581810436, "Hospitalisation ": 13.169944659777116, "Hypercapnia ": 4.335594664602928, "Hypervolaemia ": 55.13099627130838, "Hypotension ": 3.048599558976038, "Hypoxia ": 9.636424373122932, "Hysterectomy ": 3.969902988576408, "Idiopathic pulmonary fibrosis ": 2.911343106628782, "Illness ": 2.4235401947604167, "Increased bronchial secretion ": 2.9277141974958, "Infusion site erythema ": 8.782139207578485, "Infusion site haemorrhage ": 12.166212180259745, "Infusion site infection ": 40.25640677337759, "Infusion site irritation ": 29.90641575581305, "Infusion site pain ": 17.139914461970182, "Infusion site pruritus ": 9.688391800438271, "Infusion site swelling ": 13.12940867982921, "Infusion site warmth ": 21.855279499912218, "Internal haemorrhage ": 3.5998042139603865, "Intra-abdominal fluid collection ": 9.08150962349295, "Iron deficiency ": 2.4380643014211425, "Iron deficiency anaemia ": 5.241081661584681, "Left ventricular failure ": 12.504269814102663, "Liver transplant ": 12.583385700327966, "Localised infection ": 2.3605882940444314, "Lung disorder ": 2.10289114582812, "Lung transplant ": 114.28771266575342, "Mechanical ventilation ": 2.350065859815498, "Medical device change ": 75.4139689515332, "Mineral supplementation ": 62.02983418708365, "Multiple allergies ": 2.6988065021335736, "Multiple organ dysfunction syndrome ": 2.115070514807774, "N-terminal prohormone brain natriuretic peptide increased ": 7.347931725609952, "Nasal congestion ": 7.082429166701621, "Nasal dryness ": 2.3071541205084647, "Nasopharyngitis ": 2.012006443709877, "Oedema ": 6.015809866413793, "Oedema peripheral ": 5.1701702412845005, "Orthopnoea ": 6.6902349670391885, "Oxygen consumption increased ": 91.22856756866656, "Oxygen saturation abnormal ": 6.12531872656195, "Oxygen saturation decreased ": 10.51309914329442, "Oxygen therapy ": 13.125976067632, "Pain in jaw ": 18.829791754004464, "Palliative care ": 12.555415669859109, "Paracentesis ": 64.5026697992598, "Paranasal sinus discomfort ": 3.702123196102472, "Paranasal sinus hypersecretion ": 8.323526228462041, "Pericardial effusion ": 5.225951097576325, "Peripheral swelling ": 2.1505224748492897, "Platelet transfusion ": 26.24741529965362, "Pleural effusion ": 3.447341206646472, "Pneumonia ": 4.145584998703784, "Portal hypertension ": 4.102645259013127, "Portal hypertensive gastropathy ": 15.664425126822003, "Postoperative wound infection ": 2.066998286045499, "Procedural complication ": 8.669934685915337, "Product dose omission issue ": 4.517331757849565, "Product supply issue ": 2.055773797170493, "Productive cough ": 3.196057559369708, "Pulmonary alveolar haemorrhage ": 3.155913088536193, "Pulmonary arterial hypertension ": 140.53341881036673, "Pulmonary arterial pressure abnormal ": 43.99353773142183, "Pulmonary arterial pressure increased ": 71.29521420598124, "Pulmonary arterial wedge pressure increased ": 88.27062479916009, "Pulmonary artery dilatation ": 34.98929783412678, "Pulmonary congestion ": 4.969111585035855, "Pulmonary endarterectomy ": 300.32451154033663, "Pulmonary haemorrhage ": 2.559152180019192, "Pulmonary hypertension ": 31.738627186307436, "Pulmonary oedema ": 7.698999011975298, "Pulmonary thrombosis ": 2.9325382977160577, "Pulmonary veno-occlusive disease ": 50.883443068640695, "Pulseless electrical activity ": 4.8811637415524745, "Red blood cell transfusion ": 26.234829395404983, "Rehabilitation therapy ": 20.047142849401386, "Respiration abnormal ": 2.0070066495172165, "Respiratory failure ": 4.96909141395774, "Respiratory syncytial virus infection ": 3.478501779432178, "Respiratory tract congestion ": 4.499268914058862, "Respiratory tract infection viral ": 5.847635285556516, "Right ventricular dilatation ": 15.83053765456224, "Right ventricular dysfunction ": 28.88555525272328, "Right ventricular failure ": 87.0866361982028, "Right ventricular hypertrophy ": 7.783177629039145, "Right ventricular systolic pressure increased ": 29.219766772787864, "Scleroderma ": 25.40315210121928, "Seasonal allergy ": 5.242990050003099, "Secretion discharge ": 2.1248395664729496, "Sepsis ": 3.3349704607958963, "Sinus congestion ": 6.576406023088784, "Sinus disorder ": 2.505655099495208, "Skin infection ": 2.250306152536794, "Sluggishness ": 2.122619446410792, "Sputum discoloured ": 2.924145794291975, "Staphylococcal infection ": 2.5910246966929185, "Staphylococcus test positive ": 8.821875751609378, "Stent placement ": 2.8128606993852032, "Sudden death ": 3.044891098987419, "Surgery ": 3.232402278812138, "Systemic scleroderma ": 15.174113401869349, "Terminal state ": 12.696149308023712, "Therapy cessation ": 3.0212992698945387, "Therapy change ": 32.7635883429137, "Therapy interrupted ": 2.640663319889721, "Therapy non-responder ": 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": 87.93454386707116} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/820.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/820.json new file mode 100644 index 00000000000..8a5a2aabbce --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/820.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 3.942073738760807, "Abdominal distension ": 10.029114237798856, "Abdominal pain ": 4.732635404329264, "Abdominal pain lower ": 23.462033419613583, "Abortion spontaneous ": 23.42208079717694, "Ascites ": 102.59086172730392, "Haematocrit increased ": 161.93228765978904, "Incorrect route of product administration ": 21.48588750191, "Ovarian hyperstimulation syndrome ": 2249.0641223469383, "Overdose ": 5.858271996896808, "Pelvic fluid collection ": 925.225940880982, "Pleural effusion ": 9.870513781926528} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/821.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/821.json new file mode 100644 index 00000000000..dbbb57c185f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/821.json @@ -0,0 +1 @@ +{"Asthenia ": 4.496947953687483, "Hot flush ": 32.71852701561732} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/822.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/822.json new file mode 100644 index 00000000000..bea2968cf46 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/822.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 4.888808557175275, "Aspartate aminotransferase increased ": 5.5892127013615776, "Bacterial infection ": 4.663154745259368, "Blood creatine phosphokinase increased ": 5.952503525734808, "Bronchiectasis ": 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12.892589610542563, "Liver function test increased ": 4.7155056174303445, "Lower respiratory tract infection ": 2.3053675980509354, "Lung disorder ": 5.239077716003076, "Lung transplant ": 112.21702162275216, "Mood swings ": 3.379896707076513, "Nasal congestion ": 2.2737378618230006, "Nasopharyngitis ": 2.8936978937871003, "Pneumonia ": 7.335855264313565, "Pneumonia pseudomonal ": 37.72375508149661, "Pneumonia staphylococcal ": 34.55838598085397, "Pneumothorax ": 13.334877501826746, "Productive cough ": 6.474440952637258, "Pseudomonas infection ": 59.52932317879984, "Pulmonary function test decreased ": 366.0563109608832, "Rales ": 6.697439608737049, "Respiration abnormal ": 45.7458022871807, "Respiratory disorder ": 3.1851075493451675, "Respiratory failure ": 3.851561895345722, "Respiratory symptom ": 23.92436941742956, "Respiratory syncytial virus infection ": 10.525695005938278, "Respiratory tract infection ": 5.24819095864479, "Rhinovirus infection ": 27.60171613281335, "Sinus 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interaction ": 16.37897112555646, "Renal impairment ": 15.060810848822332} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/824.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/824.json new file mode 100644 index 00000000000..5b40d9539d7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/824.json @@ -0,0 +1 @@ +{"Condition aggravated ": 2.681991856107963, "Drug ineffective ": 3.390188248075743, "Drug interaction ": 3.3406336642954604, "Drug resistance ": 10.3997089083515, "Drug-induced liver injury ": 5.065667845388361, "Electrocardiogram QT prolonged ": 3.324427897010496, "Enterocolitis haemorrhagic ": 68.26254035280253, "Erythema multiforme ": 6.166523403500603, "Exposure during pregnancy ": 3.010433366954093, "Foetal death ": 14.3726956600107, "Foetal exposure during pregnancy ": 14.20124506709699, "Foetal growth restriction ": 29.65656131696017, 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/825.json @@ -0,0 +1 @@ +{"Acquired gene mutation ": 1267.3087728740286, "Cardiac failure ": 4.929872617388778, "Cardiomyopathy ": 6.939818742311763, "Cardiotoxicity ": 26.771586678691445, "Deep vein thrombosis ": 3.057609333367075, "Disease progression ": 5.982463005698374, "Drug resistance ": 104.07428461205674, "EGFR gene mutation ": 812.9786154550924, "Electrocardiogram QT prolonged ": 5.64770763476954, "Interstitial lung disease ": 16.746301250464988, "Malignant neoplasm progression ": 46.0742427092143, "Malignant transformation ": 887.0728703677532, "Metastases to bone ": 19.71399934239578, "Metastases to central nervous system ": 67.20668007534422, "Metastases to liver ": 20.23584385119665, "Metastases to lung ": 20.150139670735104, "Metastases to lymph nodes ": 19.914064423452132, "Metastases to meninges ": 313.46420020359267, "Metastasis ": 21.220950133878887, "Mucosal inflammation ": 9.77079322761784, "Myelosuppression ": 3.9137885572720768, "Off label use ": 2.22759611665831, "Paronychia ": 101.30965749809664, "Platelet count decreased ": 2.479700193737973, "Pleural effusion ": 6.853987656099673, "Pneumonitis ": 53.44695903828789, "Pulmonary embolism ": 4.272548256537188, "Respiratory failure ": 4.806542988183671, "Skin toxicity ": 23.41604806846981, "Thrombocytopenia ": 4.565497674625321, "Torsade de pointes ": 9.240178552416998} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/826.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/826.json new file mode 100644 index 00000000000..78f9563909d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/826.json @@ -0,0 +1 @@ +{"Drug reaction with eosinophilia and systemic symptoms ": 36.90327943788094, "Pruritus ": 2.706152432639293} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/827.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/827.json new file mode 100644 index 00000000000..3eece064892 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/827.json @@ -0,0 +1 @@ +{"Diarrhoea ": 2.9770304467694824, "Drug hypersensitivity ": 4.151935281439509, "Psoriasis ": 38.38255102083125, "Psoriatic arthropathy ": 26.592657008632838, "Weight decreased ": 4.909919295936933} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/828.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/828.json new file mode 100644 index 00000000000..f746bbfa5c9 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/828.json @@ -0,0 +1 @@ +{"Blood pressure increased ": 3.1218108046572746, "Drug abuse ": 7.128216886330796, "Insomnia ": 2.366340398865943, "Intentional product misuse ": 7.512509041822097, "Substance abuse ": 37.17149324059408, "Suicide attempt ": 7.229269849543266} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/829.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/829.json new file mode 100644 index 00000000000..cc54aeb3ef8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/829.json @@ -0,0 +1 @@ +{"Ovarian hyperstimulation syndrome ": 1564.2258460080902} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/83.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/83.json new file mode 100644 index 00000000000..780a780b1fe --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/83.json @@ -0,0 +1 @@ +{"Pruritus ": 27.77970820789924, "Rash ": 21.00269848737633} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/830.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/830.json new file mode 100644 index 00000000000..27f31dd8d13 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/830.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.522187518918283, "Abdominal distension ": 7.14126767522207, "Abdominal pain ": 5.493954304155022, "Abdominal pain lower ": 28.95095897584982, "Abortion spontaneous ": 9.620444076127043, "Adnexa uteri pain ": 51.017414811595714, "Adnexal torsion ": 591.9121127087847, "Ascites ": 133.2724701498231, "Breast pain ": 20.400663249231133, "Incorrect dose administered ": 4.398355316929645, "Oliguria ": 30.542230143812077, "Ovarian hyperstimulation syndrome ": 1323.0010622929744, "Pleural effusion ": 12.057259500379256, "Vaginal discharge ": 21.034741252317108} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/831.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/831.json new file mode 100644 index 00000000000..e0e40e1d8e3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/831.json @@ -0,0 +1 @@ +{"Sickle cell anaemia with crisis ": 1255.2332632313437} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/832.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/832.json new file mode 100644 index 00000000000..3792d03c899 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/832.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.377770569090449, "Abnormal behaviour ": 3.974543768811076, "Accidental overdose ": 7.830287933504132, "Adverse drug reaction ": 2.7218198777741502, "Agitation ": 2.423883306611167, "Amnesia ": 3.848524935106429, 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/835.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/835.json new file mode 100644 index 00000000000..d9c94c8db4e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/835.json @@ -0,0 +1 @@ +{"Neuropathy peripheral ": 17.53286875165086, "Off label use ": 3.681741211799794, "Product use issue ": 17.66970884703083, "Rash ": 3.71706547351106} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/836.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/836.json new file mode 100644 index 00000000000..cb91cc33a51 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/836.json @@ -0,0 +1 @@ +{"Joint injury ": 330.36144888742234, "Musculoskeletal pain ": 135.39174423901332} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/837.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/837.json new file mode 100644 index 00000000000..1f3edf862f8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/837.json @@ -0,0 +1 @@ +{"Febrile neutropenia ": 7.63696506270799, "Haemoglobin decreased ": 5.9023788002993145, "Malignant neoplasm progression ": 4.67972848222079, "Neoplasm progression ": 32.93367121164228, "Neutropenia ": 16.458955226985417, "Neutrophil count decreased ": 10.698972995350609} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/838.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/838.json new file mode 100644 index 00000000000..b1b67c5bd4d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/838.json @@ -0,0 +1 @@ +{"Agitation ": 4.417861392365098, "Alanine aminotransferase increased ": 3.1201835625851184, "Altered state of consciousness ": 5.854295983308866, "Anxiety ": 2.349022033762413, "Aspartate aminotransferase increased ": 3.1496770467135624, "Blood creatine phosphokinase increased ": 5.758346355844452, "Cardiac arrest ": 3.400350905701708, "Completed suicide ": 6.398956770838945, "Confusional state ": 2.0147222200434007, "Constipation ": 2.946819102052445, "Delusion ": 20.998724996593538, "Depression ": 3.146461521521919, "Drug abuse ": 3.801343130606583, "Drug interaction ": 5.884099235935408, "Extrapyramidal disorder ": 34.98160331614806, "Hallucination ": 4.432568208933654, "Intentional product misuse ": 3.538349011329053, "Mental status changes ": 14.321456635387635, "Muscle rigidity ": 33.29453172440556, "Myocarditis ": 6.188728971692331, "Neuroleptic malignant syndrome ": 45.18296401804053, "Platelet count decreased ": 2.02110970608891, "Schizophrenia ": 30.07224782992016, "Sinus tachycardia ": 17.46551794281048, "Toxicity to various agents ": 8.912159776758319, "Troponin increased ": 33.06369737596907} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/839.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/839.json new file mode 100644 index 00000000000..ad7eeb8880c --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/839.json @@ -0,0 +1 @@ +{"Myelosuppression ": 25.27011654010468} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/84.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/84.json new file mode 100644 index 00000000000..d887e636f89 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/84.json @@ -0,0 +1 @@ +{"Foetal exposure during pregnancy ": 6.945300574762279} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/840.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/840.json new file mode 100644 index 00000000000..9e26dfeeb6e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/840.json @@ -0,0 +1 @@ +{} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/841.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/841.json new file mode 100644 index 00000000000..54f983d8857 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/841.json @@ -0,0 +1 @@ +{"Carcinoembryonic antigen increased ": 71.55271718577454, "Colorectal cancer metastatic ": 179.06056635253694, "Conjunctivitis ": 14.84816037599784, "Constipation ": 3.746494245105028, "Decreased appetite ": 2.0507185418991187, "Dehydration ": 2.319805337464837, "Dermatitis acneiform ": 252.1960532479539, "Diarrhoea ": 2.895725298359987, "Disease progression ": 2.6827067926305115, "Drug resistance ": 5.462208552802176, "Febrile neutropenia ": 10.10843594832608, "Hepatic encephalopathy ": 23.76121476728033, "Hyperammonaemia ": 27.327104888389982, "Hypomagnesaemia ": 104.78900949670944, "Interstitial lung disease ": 8.23785319977784, "Leukopenia ": 2.493709518175643, "Metastases to liver ": 18.687314237067422, "Myelosuppression ": 4.677550248368575, "Neuropathy peripheral ": 18.821014919104133, "Neurotoxicity ": 29.940356339272107, "Neutropenia ": 11.851961271274202, "Neutrophil count decreased ": 4.382190066521645, "Palmar-plantar erythrodysaesthesia syndrome ": 5.486448857272092, "Paraesthesia ": 2.317240975091024, "Paronychia ": 236.9122316971992, "Peripheral sensory neuropathy ": 38.809223758920666, "Pneumonia aspiration ": 9.305473080743532, "Polyneuropathy ": 17.62130888824201, "Rash ": 3.5228901889837947, "Rash maculo-papular ": 3.111255042219162, "Rash pustular ": 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hypochloraemic ": 101.91377913855784, "Allergy to animal ": 47.73836835976505, "Antineutrophil cytoplasmic antibody positive ": 51.87459937090336, "Appetite disorder ": 3.460504311852878, "Asthma ": 2.3572900076589955, "Ataxia ": 5.778703416993072, "Atelectasis ": 8.742439929774813, "Atrial fibrillation ": 2.045341204475924, "Atrial flutter ": 2.286983998935986, "Bladder transitional cell carcinoma ": 44.18745718390277, "Blood magnesium decreased ": 15.218748543545493, "Blood phosphorus decreased ": 14.019854811125455, "Blood potassium decreased ": 2.955336065273546, "Blood pressure diastolic decreased ": 30.956320520812373, "Blood pressure systolic decreased ": 9.16132134477122, "Blood pressure systolic increased ": 14.128350794261628, "Blood triglycerides increased ": 3.869062506021319, "Blood urea increased ": 3.181715967550581, "Body temperature decreased ": 20.32743252237411, "Breath sounds abnormal ": 8.986749377137475, "Bronchial disorder ": 47.23891419686456, "Bronchial obstruction ": 27.16930056752932, "Bronchiectasis ": 2.5151533880274, "Bronchitis ": 3.1280184967955167, "Carcinoid tumour ": 111.28891444343508, "Cardiac failure chronic ": 8.36695659827363, "Cardiac murmur ": 2.361995770392136, "Choking ": 2.005047878103515, "Cholelithiasis ": 2.0393527855039646, "Cholestasis ": 6.456960811393289, "Chronic obstructive pulmonary disease ": 3.0829464379528, "Completed suicide ": 5.556029366366125, "Coronary artery bypass ": 7.934871352749409, "Creatinine renal clearance decreased ": 3.623678752599519, "Crohn's disease ": 2.275134595879334, "Decreased immune responsiveness ": 9.80154880107053, "Dehydration ": 2.6206706042209182, "Dilated cardiomyopathy ": 3.266267189842353, "Disease recurrence ": 5.858746857061088, "Diverticulum intestinal ": 3.407102626698349, "Drug interaction ": 2.6994336712150377, "Drug reaction with eosinophilia and systemic symptoms ": 6.759418479390445, "Duodenal ulcer ": 3.553693230843065, "Dust allergy ": 25.50882618684002, "Dyspnoea at rest ": 7.485024691876232, "Dyspnoea exertional ": 3.900207705920399, "Ecchymosis ": 3.4578867794288284, "Ejection fraction decreased ": 3.985439746696489, "Electrolyte imbalance ": 5.11357497549414, "End stage renal disease ": 3.826238388599465, "Eosinophilia ": 7.126923951347549, "Erythema nodosum ": 11.068155288946382, "Exercise tolerance decreased ": 5.143940418699156, "Eye pruritus ": 3.074106916928772, "Fall ": 2.0958945562881843, "Fixed eruption ": 6.132837367667432, "Frequent bowel movements ": 3.66422873196264, "Full blood count abnormal ": 6.221342804685814, "Gastric haemorrhage ": 2.038616831747365, "Gastritis ": 2.536647848078964, "Gastritis fungal ": 611.4482253764104, "Gastrointestinal obstruction ": 16.61317386606097, "Grandiosity ": 56.5453531010181, "Grip strength decreased ": 4.580796621850888, "Heart rate decreased ": 4.518689831524696, "Hepatic cytolysis ": 6.173434281908447, "Hepatic pain ": 3.810240650192357, "Hepatic steatosis ": 2.08926869072572, "Hepatitis A antibody abnormal ": 1130.341188694426, "Hepatitis cholestatic ": 8.286009017230423, "Hepatomegaly ": 2.6609816737329206, "Hip fracture ": 4.70474611388028, "Hypercalcaemia ": 3.4644149399409105, "Hypercholesterolaemia ": 2.142046353793268, "Hyperkalaemia ": 2.0032822689240697, "Hypernatraemia ": 6.213643666350265, "Hypocalcaemia ": 7.256601334272997, "Hypokalaemia ": 2.0284315296010758, "Hypomagnesaemia ": 18.934579906530296, "Hyponatraemia ": 5.084263988126934, "Hypopnoea ": 7.827678239651715, "Immune thrombocytopenia ": 2.2253361484162384, "Implant site dehiscence ": 213.77349202416715, "Implant site erosion ": 101.5500062207642, "Implant site erythema ": 112.87100087956834, "Implant site inflammation ": 203.80122711198308, "Implant site pruritus ": 453.741438065735, "Inappropriate antidiuretic hormone secretion ": 3.623630397504133, "Klebsiella test positive ": 112.63064890491444, "Lacrimation increased ": 2.0005300337806, "Lactic acidosis ": 2.646179865189945, "Large intestine polyp ": 12.965964232092604, "Libido increased ": 8.035659682944493, "Loss of personal independence in daily activities ": 3.928475453990444, "Low birth weight baby ": 2.836875361485474, "Lung consolidation ": 8.576661420585728, "Lung disorder ": 2.055998363455411, "Lung opacity ": 8.60266563296315, "Lymphopenia ": 2.17658035063958, "Medical device site bruise ": 512.8726411463114, "Medical device site erosion ": 120.44037892017955, "Medical device site erythema ": 147.20905208316307, "Medical device site haemorrhage ": 157.729003413971, "Mental disorder ": 7.765789611244798, "Mental impairment ": 2.60990286126989, "Mitral valve incompetence ": 3.5131424198356003, "Mood altered ": 2.5556111218383437, "Muscle atrophy ": 2.11025283295399, "Nasal polyps ": 15.022383563728509, "Needle issue ": 6.658691855814617, "Obstructive airways disorder ": 6.994172432874352, "Oesophagitis ": 2.9722990858142424, "Oral mucosal eruption ": 7.882798355272097, "Oropharyngeal discomfort ": 3.135450896599251, "Osteoarthritis ": 2.063673387923775, "Papillary renal cell carcinoma ": 170.29637498110682, "Parkinson's disease ": 4.848278624168591, "Persecutory delusion ": 12.139531286875318, "Petechiae ": 2.1824334867224597, "Platelet count increased ": 3.0373225541014124, "Pleuritic pain ": 13.008268417714902, "Poisoning ": 2.670251031494801, "Pregnancy ": 2.241306864260675, "Premature labour ": 8.194132050849895, "Productive cough ": 4.8275802264505145, "Pseudomembranous colitis ": 7.692721310931113, "Psychiatric symptom ": 3.35382497446061, "Pulmonary congestion ": 2.6408026265386635, "Rash maculo-papular ": 6.852038565926217, "Rash pustular ": 4.145341114980701, "Rebound acid hypersecretion ": 201.99861287978104, "Seasonal allergy ": 6.329050494785357, "Shock haemorrhagic ": 2.5752072038580494, "Sleep disorder due to a general medical condition ": 9.535732436272411, "Spinal stenosis ": 6.454710541672579, "Suspected suicide ": 13.106112024400746, "Symmetrical drug-related intertriginous and flexural exanthema ": 36.53741958684044, "Therapeutic product effect incomplete ": 3.319942534893044, "Therapy cessation ": 4.831832781075586, "Therapy interrupted ": 5.390020646762437, "Tonsil cancer ": 40.74595820885498, "Toxic epidermal necrolysis ": 6.325751750610192, "Toxic skin eruption ": 2.0691621885211884, "Tricuspid valve incompetence ": 4.351704328288826, "Troponin increased ": 4.382389157100061, "Tubulointerstitial nephritis ": 8.869809462172421, "Urinary incontinence ": 3.3485943975497943, "Ventricular hypertrophy ": 38.86235888093664, "Ventricular hypokinesia ": 18.019966680824023, "Vitamin B12 decreased ": 36.46712627755692, "Vitamin B12 deficiency ": 14.746295557780602, "Wheelchair user ": 7.979754646464273, "Wheezing ": 5.52654720712097} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/843.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/843.json new file mode 100644 index 00000000000..e3594f5ffb0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/843.json @@ -0,0 +1 @@ +{"Anaphylactic reaction ": 46.2812076369364} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/844.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/844.json new file mode 100644 index 00000000000..99808ef2113 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/844.json @@ -0,0 +1 @@ +{"Anaemia ": 4.122422400007743, "Blood glucose increased ": 7.9578876685045135, "Blood pressure increased ": 9.312455956084708, "Concomitant disease aggravated ": 143.31916048400728, "Cough ": 3.281079737210412, "Diabetes mellitus ": 53.81031866087957, "Diabetes mellitus inadequate control ": 15.64736701682251, "Diarrhoea ": 2.119854734739539, "Drug ineffective ": 3.413064967226218, "Faeces discoloured ": 49.47961987141578, "Glucose tolerance impaired ": 115.57485983627264, "Glycosylated haemoglobin increased ": 17.48409997184417, "Hyperglycaemia ": 27.339750345512016, "Inappropriate schedule of product administration ": 8.664967430745136, "Nasopharyngitis ": 8.985880492502382, "Neoplasm malignant ": 21.03353439972257, "Nocturia ": 116.77161584677452, "Oropharyngeal pain ": 8.802529081531612, "Product use in unapproved indication ": 3.223705755156072, "Sleep apnoea syndrome ": 78.53406379154528, "Type 2 diabetes mellitus ": 23.623451677332252, "Weight increased ": 3.757924022007887} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/845.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/845.json new file mode 100644 index 00000000000..cd68eefdd26 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/845.json @@ -0,0 +1 @@ +{"Balance disorder ": 3.776642041061872, "Bradycardia ": 4.522539105533408, "COVID-19 ": 2.9767309870690646, "Confusional state ": 2.7840659761709534, "Contraindicated product administered ": 5.171335477168774, "Decreased appetite ": 2.1039853110875737, "Diarrhoea ": 2.2100780189255773, "Drug interaction ": 15.386146296622652, "Dysgeusia ": 17.681183237595107, "Feeling abnormal ": 2.7775552601216478, "Urinary tract infection ": 3.4181698885354312} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/846.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/846.json new file mode 100644 index 00000000000..7f6c9c36024 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/846.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 6.005476762618425, "Alveolar soft part sarcoma ": 2393.722277868474, "Amylase increased ": 5.899918398429357, "Ascites ": 2.204751588921844, "Aspartate aminotransferase increased ": 4.96016328553554, "Blood alkaline phosphatase increased ": 2.1979120649952697, "Blood bilirubin increased ": 7.800948825404019, "Blood pressure increased ": 2.1557975006304075, "Blood pressure systolic increased ": 4.562947080318598, "Blood thyroid stimulating hormone increased ": 12.126120596847892, "Cardiac failure ": 2.169485130122355, "Clear cell renal cell carcinoma ": 376.3078547219088, "Decreased appetite ": 3.4464240193774587, "Diarrhoea ": 2.95250785084866, "Disease progression ": 4.687897009170715, "Drug-induced liver injury ": 5.510970339677155, "Ewing's sarcoma ": 190.91307841316643, "Gastrointestinal toxicity ": 14.277915741464014, "Haemoptysis ": 2.8429838048179588, "Hair colour changes ": 69.88264006999313, "Hepatic failure ": 2.9361488499410715, "Hepatic function abnormal ": 5.457018408316558, "Hepatotoxicity ": 21.881884249347717, "Hyperbilirubinaemia ": 8.237906255736153, "Hypertension ": 5.495674879670127, "Hypertransaminasaemia ": 7.294641958004463, "Hypothyroidism ": 7.411496511870068, "Intestinal perforation ": 8.819903321288153, "Jaundice ": 2.985917401333833, "Leiomyosarcoma ": 233.90928402187205, "Liver function test abnormal ": 2.583598603221104, "Liver function test increased ": 4.620312609536337, "Liver injury ": 3.2495188569297917, "Malignant neoplasm progression ": 38.95369816501778, "Metastases to bone ": 12.616916336947613, "Metastases to central nervous system ": 17.219248089598665, "Metastases to liver ": 10.105666365323083, "Metastases to lung ": 47.94854878515119, "Metastases to lymph nodes ": 18.11540227348305, "Metastases to spine ": 23.342671409656152, "Metastatic renal cell carcinoma ": 52.539787273854216, "Mucosal inflammation ": 2.913754855245118, "Neoplasm progression ": 2.3883253303420777, "Nephrotic syndrome ": 6.527876194109605, "Neutropenia ": 2.14011295883924, "Osteosarcoma metastatic ": 862.0287985077421, "Palmar-plantar erythrodysaesthesia syndrome ": 16.5570235431447, "Platelet count decreased ": 2.5470386332828068, "Pleural effusion ": 3.8665750483282393, "Pneumothorax ": 32.419494668662544, "Posterior reversible encephalopathy syndrome ": 12.325488290256157, "Product use in unapproved indication ": 8.362667981663801, "Proteinuria ": 9.60978881754176, "Pulmonary mass ": 4.235672980853655, "Renal cancer ": 3.280296527797834, "Renal cell carcinoma ": 29.374748934370736, "Soft tissue sarcoma ": 266.8290850373411, "Taste disorder ": 2.1667296057952354, "Therapeutic response decreased ": 6.040715336343409, "Therapy partial responder ": 13.153834687498836, "Thrombocytopenia ": 2.639548826243912, "Transaminases increased ": 10.601328872373006} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/847.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/847.json new file mode 100644 index 00000000000..193b6651569 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/847.json @@ -0,0 +1 @@ +{"Abdominal pain ": 2.2665945999167167, "Agranulocytosis ": 13.683229995519577, "Anaphylactic reaction ": 2.841899556835528, "Antithrombin III decreased ": 575.9895961791626, "Coagulopathy ": 15.246538514936956, "Embolism venous ": 191.89311462798915, "Febrile neutropenia ": 15.743999083044455, "Granulocytopenia ": 22.93374745433444, "Haemoglobin decreased ": 2.150854898690236, "Hepatic function abnormal ": 2.9499715632230257, "Hypersensitivity ": 3.895219141871332, "Hypertriglyceridaemia ": 55.46322503486626, "Infection ": 3.015463228536685, "Leukopenia ": 3.1753234105710217, "Myelosuppression ": 92.99782563488202, "Neutrophil count decreased ": 7.549995066028913, "Pancreatitis ": 5.48124796280896, "Pancytopenia ": 7.840648745542014, "Platelet count decreased ": 6.097167600834943, "Thrombocytopenia ": 3.039499043319568, "Urticaria ": 2.684207431501586, "White blood cell count decreased ": 8.112431180730317} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/848.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/848.json new file mode 100644 index 00000000000..6b9b063f59d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/848.json @@ -0,0 +1 @@ +{"Abdominal infection ": 2.394671059154865, "Abortion spontaneous ": 2.114093662417026, "Abscess ": 2.8200358057637023, "Abscess limb ": 3.1456478539677666, "Acquired haemophilia ": 3.138899803904076, "Acute psychosis ": 3.270185807663208, "Acute stress disorder ": 2.969714753494276, "Affective disorder ": 2.073042001878912, "Alanine aminotransferase abnormal ": 3.366536908045192, "Alanine aminotransferase increased ": 2.4862034969428417, "Alcohol use ": 6.55870769963997, "Alcoholism ": 2.148644745952752, "Alopecia ": 3.020918928808236, "Alopecia totalis ": 3.1805242980303534, "Alpha 1 foetoprotein increased ": 10.339133414728591, "Ammonia increased ": 8.490191464134423, "Anaemia ": 10.856081212774754, "Anaemia macrocytic ": 4.5229869174040775, "Anal fissure ": 2.238158940034937, "Anal haemorrhage ": 2.6022841428211843, "Anal inflammation ": 4.660851110761988, "Anal pruritus ": 28.45281085338077, "Anger ": 4.828531391228215, "Angular cheilitis ": 6.427978045524723, "Anorectal discomfort ": 37.35516016730588, "Anorectal disorder ": 5.565616156234569, "Anti-thyroid antibody positive ": 3.157985364535693, "Aplasia pure red cell ": 2.114870246685556, "Aplastic anaemia ": 4.636340723237672, "Appendicectomy ": 2.226816329081166, "Appetite disorder ": 2.1208590456183827, "Arthritis bacterial ": 2.023159462034352, "Ascites ": 4.447282353762029, "Aspartate aminotransferase abnormal ": 2.097610924178935, "Atypical pneumonia ": 2.232197470738288, "Autoimmune haemolytic anaemia ": 5.221186678051403, "Autoimmune hepatitis ": 4.425602181478599, "Autoimmune thyroiditis ": 4.758853497458105, "Biliary obstruction ": 2.3751071361874816, "Bipolar I disorder ": 4.610085778720421, "Bipolar disorder ": 2.7897418349701733, "Blood albumin decreased ": 2.340341314977856, "Blood bilirubin increased ": 2.3129320299976044, "Blood disorder ": 2.9058122341275303, "Blood electrolytes decreased ": 3.5058034967179688, "Blood iron increased ": 3.686231978703912, "Blood potassium abnormal ": 2.820045882152264, "Blood potassium decreased ": 3.145081888916673, "Blood test abnormal ": 2.8223681388621675, "Blood thyroid stimulating hormone decreased ": 4.843458456607736, "Blood thyroid stimulating hormone increased ": 3.965919619290296, "Blood triglycerides increased ": 2.433619121002644, "Blood uric acid increased ": 2.2211819539518656, "Bone marrow disorder ": 3.567110032805449, "Bone marrow failure ": 2.340701173798871, "Bone marrow oedema ": 2.9542107648907314, "Brain abscess ": 2.553401724187239, "Brain hypoxia ": 2.0026783142203635, "Brain stem haemorrhage ": 2.251000747453597, "Carbohydrate antigen 19-9 increased ": 4.272514641406242, "Cellulitis ": 2.1801629576672634, "Cerebellar haemorrhage ": 2.882877143779838, "Chapped lips ": 2.70185097197796, "Chorea ": 2.4858534341170944, "Chronic hepatic failure ": 8.225071437874885, "Chronic hepatitis C ": 9.53626242358278, "Clubbing ": 5.540838200373807, "Colitis ischaemic ": 3.7135905529107336, "Coma hepatic ": 2.1299743612146083, "Crying ": 2.001387773829051, "Cryoglobulinaemia ": 21.537640796997987, "Cutaneous sarcoidosis ": 8.232388210848448, "Deafness ": 2.204780301795479, "Deafness unilateral ": 2.271282694386239, "Decreased appetite ": 2.473128561778609, "Dehydration ": 2.9914671167591065, "Demyelinating polyneuropathy ": 2.397865990226409, "Dental caries ": 2.095454291685986, "Dental restoration failure ": 4.119843891416878, "Depression ": 6.374490651132759, "Depressive symptom ": 2.622464177618415, "Dermal cyst ": 2.4183025313187896, "Dermatitis ": 2.3261861166993985, "Dermatitis infected ": 7.027374826211197, "Diabetes mellitus ": 2.036904087521839, "Drug specific antibody absent ": 2.7744894909161397, "Dry skin ": 5.326728429618185, "Dyschezia ": 3.7787155897268376, "Dysgeusia ": 2.6576526095404804, "Emotional disorder ": 2.4549170492396573, "Empyema ": 2.555324873058888, "Endocarditis ": 3.8035423732818976, "Endocarditis bacterial ": 3.966557141860426, "Endodontic procedure ": 3.844208586611816, "Eosinophil count decreased ": 2.1210880057740438, "Erythema nodosum ": 2.434671991097386, "Escherichia sepsis ": 2.921100836387362, "Exposure via body fluid ": 2.433652797289394, "Exposure via skin contact ": 2.6800920082488298, "Failure to thrive ": 4.895895703818265, "Fat tissue increased ": 2.1568549551210863, "Fibrosis ": 2.5639962661187194, "Full blood count abnormal ": 2.665764304262987, "Full blood count decreased ": 8.724457781966105, "Furuncle ": 2.5750134696979226, "Gallbladder polyp ": 3.80025163421434, "Gastric pH decreased ": 2.872197029649099, "Gingival bleeding ": 3.71265382402777, "Gingival pain ": 2.3317856275493303, "Granulocyte count decreased ": 7.660713173576283, "Granulocytopenia ": 5.520841947653116, "Granulomatous liver disease ": 4.532703579706318, "Graves' disease ": 4.517214762417995, "Gravitational oedema ": 2.6643805846401776, "Haemangioma of liver ": 3.0180354213133453, "Haematemesis ": 2.233979819319233, "Haematocrit abnormal ": 5.25921771551082, "Haematocrit decreased ": 6.866375065843592, "Haematology test abnormal ": 8.399116914428886, "Haemochromatosis ": 8.25056931707855, "Haemoglobin ": 20.63941900416405, "Haemoglobin abnormal ": 4.651654299375388, "Haemoglobin decreased ": 9.655638470666378, "Haemolytic anaemia ": 8.697255856136703, "Haemorrhoidal haemorrhage ": 2.493162542268886, "Haemorrhoids ": 4.931697417775261, "Haemorrhoids thrombosed ": 3.2380903027789647, "Hand dermatitis ": 2.356356897487794, "Hepatic cancer ": 2.730850008307717, "Hepatic cancer recurrent ": 8.891482554877246, "Hepatic cirrhosis ": 10.55538089373633, "Hepatic encephalopathy ": 5.130926981523602, "Hepatic failure ": 3.443414651590041, "Hepatic fibrosis ": 4.754606118452727, "Hepatic mass ": 3.794014914531565, "Hepatic neoplasm ": 3.3080952244922788, "Hepatic pain ": 8.362370050043396, "Hepatitis B DNA increased ": 3.472633003225663, "Hepatitis B surface antigen positive ": 13.26700719516867, "Hepatitis C ": 10.999716272042145, "Hepatitis C RNA increased ": 29.76771912571276, "Hepatitis C RNA positive ": 17.49627553969152, "Hepatitis C virus test ": 40.57473560326963, "Hepatitis C virus test positive ": 11.618981624459783, "Hepatocellular carcinoma ": 2.308174788477719, "Hepatorenal failure ": 5.791091835619644, "Homicidal ideation ": 11.84520654733562, "Homicide ": 2.7195326283713595, "Hyperparathyroidism ": 6.265516394401678, "Hyperthyroidism ": 6.011153763663096, "Hypothyroidism ": 5.313897539842043, "Immune thrombocytopenia ": 3.4697071477254227, "Impatience ": 3.646684457617973, "Infected cyst ": 5.59189523804532, "Infected skin ulcer ": 2.1984251621212323, "Infertility ": 2.906384737347863, "Injection site bruising ": 3.0045083914284625, "Injection site infection ": 3.627809809232158, "Injection site rash ": 4.488240407203239, "Injection site ulcer ": 2.5739437988065528, "Insomnia ": 3.0587966948514373, "Intercepted product storage error ": 35.60219331159884, "Interstitial lung disease ": 3.715013316673896, "Iron overload ": 3.2150869425324564, "Irritability ": 5.051250139894244, "Klebsiella bacteraemia ": 3.1353055812921675, "Laboratory test abnormal ": 2.6750691600372205, "Leukopenia ": 5.398825452045159, "Limb mass ": 2.6378063666562963, "Liver tenderness ": 4.323495871313302, "Liver transplant ": 2.4687698225527845, "Liver transplant rejection ": 3.294369690463115, "Loose tooth ": 2.891460078326796, "Lung abscess ": 2.005352668416377, "Lymph node tuberculosis ": 2.949003532312677, "Lymphocyte count increased ": 3.182507242259926, "Macrocytosis ": 3.1822239735592426, "Major depression ": 2.599668333410378, "Mass ": 2.1574938055007142, "Memory impairment ": 2.35219547194414, "Meningitis viral ": 2.343774189009945, "Mental disorder ": 2.5043278693789026, "Mononeuropathy multiplex ": 5.523378368757425, "Mood altered ": 3.9170019104844354, "Mood swings ": 3.773605450971736, "Mouth injury ": 2.0821070060505384, "Muscle abscess ": 4.729710007216791, "Nasal ulcer ": 3.2651175792031752, "Nephrotic syndrome ": 2.2435592816047065, "Nervousness ": 2.1920055466226738, "Neutropenia ": 4.936914367766404, "Neutrophil count abnormal ": 5.209846730989928, "Neutrophil count decreased ": 8.76777296289789, "No adverse event ": 3.959864859315759, "Ocular vascular disorder ": 3.534021348166976, "Oesophageal varices haemorrhage ": 7.543699955078122, "Optic ischaemic neuropathy ": 4.439784482206279, "Optic neuritis ": 2.159315863619944, "Optic neuropathy ": 2.4748696296274693, "Oral fungal infection ": 3.160035187627252, "Oral infection ": 3.1820411826383297, "Oral lichen planus ": 2.498449708420172, "Oral mucosal blistering ": 3.297024115683356, "Osmotic demyelination syndrome ": 7.2797245048246015, "Pancytopenia ": 5.848013727865227, "Papilloedema ": 2.7331147756334957, "Paranoia ": 3.679762711832305, "Paternal exposure timing unspecified ": 8.31624681105071, "Peripheral motor neuropathy ": 2.9221716322032134, "Peripheral sensorimotor neuropathy ": 2.0087261054667325, "Peritonitis bacterial ": 3.8031219938512897, "Peroneal nerve palsy ": 2.3608292066645986, "Pharyngeal disorder ": 2.8197355795100525, "Pharyngeal ulceration ": 5.874985072507446, "Physical assault ": 2.0237567444924363, "Platelet count abnormal ": 4.764929184154894, "Platelet count decreased ": 9.857234295713363, "Platelet disorder ": 4.254657659778611, "Pleurisy ": 2.493331852741769, "Pneumococcal sepsis ": 3.7472211405682647, "Pneumonia pneumococcal ": 2.442649027553118, "Pneumonia staphylococcal ": 2.957090187807436, "Pneumonia streptococcal ": 7.061844426530764, "Polymyositis ": 6.100394054249318, "Porphyria non-acute ": 16.16536088612806, "Portal hypertension ": 5.313027487976421, "Pregnancy of partner ": 12.513707960459236, "Procedural complication ": 2.394694919680528, "Proctalgia ": 6.765729653415421, "Product counterfeit ": 2.4270704554170552, "Prurigo ": 3.3932990885150165, "Psoas abscess ": 4.096950187522695, "Psoriasis ": 2.3397961595430514, "Psychotic disorder ": 4.165478632477139, "Pulmonary granuloma ": 2.546950649512058, "Pulmonary sarcoidosis ": 8.894496582030062, "Pulmonary tuberculosis ": 2.913748357730022, "Rash ": 2.0168070429978293, "Rectal abscess ": 5.259920454766123, "Red blood cell abnormality ": 6.155601416996599, "Red blood cell count abnormal ": 3.7122073522632566, "Red blood cell count decreased ": 19.262463026304136, "Red blood cell count increased ": 2.1716365869484715, "Red blood cell morphology abnormal ": 20.63941900416405, "Red blood cell transfusion ": 2.3889335889434657, "Respiratory tract congestion ": 2.5453298115621683, "Reticulocyte count decreased ": 3.308455097905944, "Retinal artery thrombosis ": 4.077166531413983, "Retinal detachment ": 4.440742394406674, "Retinal disorder ": 3.690120327247411, "Retinal exudates ": 36.38676998837902, "Retinal haemorrhage ": 8.884964568376708, "Retinal injury ": 2.335385519740654, "Retinal ischaemia ": 3.854736152723765, "Retinal tear ": 2.89043483767409, "Retinal vascular thrombosis ": 2.4073594416780324, "Retinal vein thrombosis ": 3.852955619705516, "Retinitis ": 3.638104008018494, "Retinopathy ": 13.870868379099276, "Saliva altered ": 2.2615832925699286, "Salmonellosis ": 4.93995077456119, "Sarcoidosis ": 14.46405046873486, "Scrotal swelling ": 2.8410989769345627, "Self-injurious ideation ": 5.67433429611298, "Sepsis ": 2.259438918384433, "Serum ferritin increased ": 3.3735598977719947, "Sjogren's syndrome ": 2.075421285968232, "Skin fissures ": 3.6001088599828157, "Skin infection ": 2.1935926577847207, "Skin laceration ": 2.036222775639738, "Skin ulcer ": 3.695326758901957, "Splenomegaly ": 3.061192303909928, "Spondylitis ": 2.3040922480987542, "Spontaneous bacterial peritonitis ": 19.099931836037594, "Sputum abnormal ": 2.8273863177485663, "Staphylococcal infection ": 3.1196453740335053, "Staphylococcal sepsis ": 3.9824985413981504, "Staphylococcal skin infection ": 7.225551169262287, "Subcutaneous abscess ": 2.2214322708335352, "Sudden hearing loss ": 2.162228198410713, "Sudden visual loss ": 6.140997253798575, "Suicidal ideation ": 4.10570553554784, "Taste disorder ": 2.2379391352285785, "Testicular swelling ": 3.4487037979944333, "Therapeutic product ineffective ": 4.127230288387025, "Therapeutic response delayed ": 2.0026783142203635, "Therapy non-responder ": 3.5095080434469907, "Thinking abnormal ": 2.238463428566778, "Thrombocytopenia ": 4.416026190709739, "Thrombocytopenic purpura ": 3.114171628324546, "Thrombotic thrombocytopenic purpura ": 3.595159884021149, "Thyroid disorder ": 4.371569488329394, "Thyroid function test abnormal ": 9.533002508274675, "Thyroid hormones increased ": 4.458305022485583, "Thyroiditis ": 5.011843303437852, "Thyroiditis acute ": 5.4604569705428805, "Thyroxine increased ": 3.674212625672781, "Tongue disorder ": 2.371113596964113, "Tongue erythema ": 2.197327208547188, "Tooth abscess ": 2.544499742450005, "Tooth infection ": 2.2149747826574537, "Toxic shock syndrome ": 5.732189841457928, "Transfusion ": 8.967226893388936, "Trisomy 21 ": 2.6579682507136004, "Tuberculin test positive ": 2.172627861645715, "Tuberculosis ": 2.311289699114206, "Tuberculous pleurisy ": 4.891064107128184, "Tympanic membrane perforation ": 2.180159899447024, "Type 1 diabetes mellitus ": 5.593327030678427, "Underweight ": 2.474092611415737, "Urosepsis ": 2.496483875191424, "Varices oesophageal ": 13.218864828360244, "Violence-related symptom ": 4.367869339207155, "Viral load decreased ": 16.132272360540007, "Viral load increased ": 22.90058888141333, "Viral test positive ": 4.785999630580513, "Virologic failure ": 2.1131899223825954, "Vision blurred ": 2.05337653587614, "Vogt-Koyanagi-Harada disease ": 10.081442698463515, "Weight decreased ": 4.122401412320108, "White blood cell count abnormal ": 3.66934892534104, "White blood cell count decreased ": 14.329082505493377, "White blood cell disorder ": 7.37444050070655} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/849.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/849.json new file mode 100644 index 00000000000..b56aaac925d --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/849.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.2689764200619247, "Agranulocytosis ": 2.809958748333007, "Anaemia ": 2.814067266152577, "Anaphylactic reaction ": 2.145119190993866, "Aortitis ": 613.5579472683735, "Arrhythmia ": 5.632229392640844, "Blood lactate dehydrogenase increased ": 18.46529312678713, "Bone pain ": 26.96172059293343, "Bronchitis ": 4.748375636996808, "C-reactive protein increased ": 10.39945341041051, "Embolism ": 21.819417677679464, "Febrile neutropenia ": 49.12868073982738, "General physical health deterioration ": 7.686962778184768, "Infection ": 4.571167718882419, "Leukocytosis ": 11.068767733409931, "Leukopenia ": 8.335218267401745, "Mucosal inflammation ": 13.12904535157648, "Myelosuppression ": 2.175068292087747, "Neutropenia ": 11.04271500012666, "Neutrophil count decreased ": 13.693435977510296, "Pneumonia ": 3.004271124115495, "Pulmonary embolism ": 3.4296730116728518, "Pulmonary thrombosis ": 17.390031690283337, "Sepsis ": 5.571065086426875, "Stomatitis ": 2.6350230536707504, "Thrombocytopenia ": 4.760673530303117, "Urinary tract infection ": 4.063659520204881, "Vasculitis ": 10.577852194339638, "White blood cell count decreased ": 4.027264239750097} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/85.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/85.json new file mode 100644 index 00000000000..f57135c0ffa --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/85.json @@ -0,0 +1 @@ +{"Abdominal distension ": 2.102098540673646, "Abnormal behaviour ": 7.656193957164304, "Aggression ": 4.091737896443417, "Agitation ": 3.16552049140356, "Decreased interest ": 41.17722194602349, "Dehydration ": 2.361467071903381, "Drug interaction ": 2.8139688350245, "Exposure during pregnancy ": 4.752764445805536, "Fear ": 8.642087545705975, "Hallucination, auditory ": 7.925452504116055, "Hypokalaemia ": 2.498696863856688, "Inappropriate affect ": 96.89138874033952, "Intentional product misuse ": 2.0501502427803837, "Irritability ": 2.3182879642361813, "Live birth ": 24.482197729375407, "Lung disorder ": 5.23722881344897, "Maternal exposure during pregnancy ": 3.256675899068878, "Memory impairment ": 2.291643309185935, "Mental status changes ": 16.5333227963875, "Normal newborn ": 32.74166895002574, "Paranoia ": 26.71934929252364, "Pneumonia ": 2.4517125532394286, "Premature baby ": 4.105853583309913, "Respiratory failure ": 2.812617853814052, "Social avoidant behaviour ": 29.35255761224113, "Substance abuse ": 8.95778877498611, "Substance-induced psychotic disorder ": 64.38417378455624, "Urinary tract infection ": 4.69448113040033} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/850.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/850.json new file mode 100644 index 00000000000..1b41ce6abf1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/850.json @@ -0,0 +1 @@ +{"Abdominal tenderness ": 2.05175768503502, "Adverse event ": 2.486045021160743, "Alanine aminotransferase increased ": 2.1932950732357, "Alopecia totalis ": 24.299120254590505, "Alopecia universalis ": 86.02430164649437, "Anaemia ": 18.12663363403021, "Anal haemorrhage ": 6.423823976199437, "Anal pruritus ": 67.68052608117532, "Angiotensin converting enzyme increased ": 70.14436932856873, "Anorectal discomfort ": 30.33917692142135, "Anorectal disorder ": 8.284601741361508, "Aplasia pure red cell ": 7.73264308463609, "Aplastic anaemia ": 7.197434266897775, "Ascites ": 3.7841851538138807, "Autoimmune haemolytic anaemia ": 8.787393852965156, "Autoimmune hepatitis ": 12.574081858862918, "Autoimmune thyroiditis ": 9.667195420543443, "Bilirubin conjugated increased ": 4.750818852246233, "Blood bilirubin increased ": 2.3208578132636024, "Blood creatinine increased ": 2.1289510188418657, "Blood disorder ": 9.098414215858968, "Blood urea increased ": 2.052053170207212, "Blood uric acid increased ": 4.5403269253159015, "Bone marrow failure ": 3.902716244180676, "Chronic hepatitis C ": 87.96849830878531, "Coeliac disease ": 2.0860795364404403, "Colitis ischaemic ": 4.380923873031978, "Cryoglobulinaemia ": 27.820140695207844, "Cutaneous sarcoidosis ": 80.12832841453931, "Cutaneous vasculitis ": 2.0604717485991317, "Cytopenia ": 4.204027216059306, "Deafness neurosensory ": 9.773174139675096, "Decreased appetite ": 2.593341374186155, "Depression ": 4.292448384359702, "Dermatitis ": 2.5641203226093623, "Disease recurrence ": 2.278641552618645, "Drug eruption ": 4.110204965752982, "Drug reaction with eosinophilia and systemic symptoms ": 11.392028513729947, "Dry skin ": 4.629284477818826, "Erysipelas ": 2.00152995649778, "Erythema multiforme ": 3.9199138697663782, "Escherichia infection ": 5.899741271473969, "Factor VIII inhibition ": 4.734202100470303, "Glomerular filtration rate decreased ": 2.972268343849347, "Granuloma ": 5.031263637677742, "Graves' disease ": 7.60540509998259, "Haemoglobin decreased ": 9.07603874253652, "Haemolysis ": 2.2511420796755077, "Haemolytic anaemia ": 7.266141775465452, "Haemorrhoidal haemorrhage ": 7.772747236671253, "Haemorrhoids ": 9.805466173611904, "Hepatic cancer ": 2.6258783517408126, "Hepatic cirrhosis ": 5.24890516232784, "Hepatic encephalopathy ": 6.438705734719675, "Hepatic failure ": 5.390482336424336, "Hepatic pain ": 3.140197980507461, "Hepatitis C ": 31.911282572903563, "Hepatitis chronic active ": 51.8312100964621, "Hepatocellular carcinoma ": 6.808505291656262, "Hepatorenal syndrome ": 10.755862477019967, "Hyperbilirubinaemia ": 4.504520115829125, "Hyperthyroidism ": 5.790279601059841, "Hyperuricaemia ": 23.365808676321887, "Hypothyroidism ": 2.484518463119456, "Hypovolaemia ": 2.757941523948967, "Immune thrombocytopenia ": 4.159875894222123, "Injection site necrosis ": 6.651264214852836, "Interstitial lung disease ": 2.073324629199424, "Irritability ": 2.3774481633318847, "Leukopenia ": 8.592014690829139, "Liver transplant ": 9.091632786840236, "Liver transplant failure ": 216.20921605597152, "Liver transplant rejection ": 13.699027567553191, "Lung infiltration ": 3.349489498541369, "Lymph node tuberculosis ": 27.136394997868923, "Lymphadenopathy mediastinal ": 5.910927332641744, "Lymphopenia ": 3.106132958839261, "Major depression ": 2.7815453689361043, "Mental disorder ": 3.125436440683549, "Monocyte count increased ": 5.066591548712127, "Mood altered ": 3.1912271811445683, "Mouth ulceration ": 3.348314523951591, "Myasthenia gravis ": 2.538010425065013, "Mycobacterium abscessus infection ": 39.40274218024246, "Neutropenia ": 5.444309064908002, "Neutrophil count decreased ": 2.188947101101673, "Oesophageal candidiasis ": 3.590199469276407, "Optic ischaemic neuropathy ": 6.866297589043155, "Optic neuropathy ": 9.950603839118072, "Oral candidiasis ": 2.384868751403672, "Oral disorder ": 3.681851384405282, "Organising pneumonia ": 3.297238594525865, "Pancreatitis acute ": 2.693064518090718, "Pancytopenia ": 6.1828429366359225, "Papule ": 2.158713462508949, "Platelet count decreased ": 4.439588413347259, "Porphyria non-acute ": 41.67349272695679, "Proctalgia ": 13.737783149482118, "Pruritus ": 2.547932403338558, "Psoriasis ": 2.5079651191003878, "Psychotic disorder ": 3.820405327661158, "Pulmonary sarcoidosis ": 44.70135045759712, "Pulmonary tuberculosis ": 9.361609573384415, "Rales ": 2.1896283999018222, "Rash ": 3.293465344417725, "Red blood cell count decreased ": 2.1769398448989614, "Red blood cell transfusion ": 11.510305786449738, "Renal impairment ": 2.4327356714257933, "Retinal exudates ": 64.12214875453809, "Retinal haemorrhage ": 8.071470233191773, "Retinal ischaemia ": 87.61303857610712, "Retinal vein occlusion ": 3.3561024058885565, "Retinopathy ": 46.848390521921615, "Sarcoidosis ": 38.58698353506783, "Sepsis ": 2.4544871203342327, "Serum ferritin increased ": 4.434013604529469, "Skin hyperpigmentation ": 2.8590961768122565, "Skin lesion ": 2.376360741241249, "Skin mass ": 2.8792148646658746, "Skin plaque ": 6.559127872448173, "Skin reaction ": 2.527961094190675, "Skin ulcer ": 2.9075215145798965, "Spontaneous bacterial peritonitis ": 21.26076367312149, "Staphylococcal bacteraemia ": 5.882792861410981, "Staphylococcal sepsis ": 4.902448837393527, "Stevens-Johnson syndrome ": 2.3941538326788865, "Sudden hearing loss ": 2.9991412085072646, "Therapy non-responder ": 7.352327101590116, "Thrombocytopenia ": 6.69414669382517, "Thrombotic thrombocytopenic purpura ": 4.45445813904927, "Thyroiditis ": 3.3266136747177044, "Toxic skin eruption ": 3.906682617415401, "Transaminases increased ": 2.1330957442382337, "Transfusion ": 10.60633124393717, "Transplant failure ": 9.662342030301026, "Transplant rejection ": 3.826532961537925, "Treatment failure ": 4.141818999594627, "Tuberculosis ": 3.5212570658391678, "Type 1 diabetes mellitus ": 7.587471402362171, "Urosepsis ": 2.5348248441830563, "Viraemia ": 12.363230589761692, "Viral load increased ": 6.039716537112199, "Virologic failure ": 15.943060221728189, "Visual acuity reduced ": 2.4734504262372723, "Vogt-Koyanagi-Harada disease ": 38.49693201227187, "Weight decreased ": 3.0624903048551, "White blood cell count decreased ": 3.2334232606248388} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/851.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/851.json new file mode 100644 index 00000000000..e013f6469a7 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/851.json @@ -0,0 +1 @@ +{"Abnormal sensation in eye ": 2.084322590103024, "Abortion induced ": 7.867377124620278, "Abortion spontaneous ": 2.320057112257917, "Abscess ": 3.824662725041792, "Acute psychosis ": 5.606059565663121, "Acute respiratory distress syndrome ": 3.177103189258625, "Adverse event ": 2.0007126100283528, "Affect lability ": 2.0667101406331296, "Aggression ": 3.2070435027517714, "Alcohol abuse ": 2.522592023484853, "Alcoholism ": 10.367670195178016, "Alopecia ": 2.475212123268486, "Alopecia universalis ": 9.122425473278778, "Alveolitis ": 4.49384184019817, "Ammonia increased ": 3.3838107428023614, "Amnesia ": 2.071123063389523, "Anaemia ": 9.990574269084108, "Anaemia macrocytic ": 2.887803207817908, "Anal pruritus ": 3.9272887637429887, "Anger ": 3.96912224177088, "Anorectal discomfort ": 3.7577784435142942, "Anti-neutrophil cytoplasmic antibody positive vasculitis ": 4.091608767835779, "Anti-thyroid antibody positive ": 7.516104243376881, "Aplasia pure red cell ": 6.453376607821674, "Appendicitis ": 5.360149010088953, "Appetite disorder ": 2.3135784099238754, "Arthritis bacterial ": 2.976347410812122, "Ascites ": 3.2844314620525217, "Autoimmune haemolytic anaemia ": 4.711918642980698, "Autoimmune hepatitis ": 8.120395641296605, "Autoimmune thyroiditis ": 5.786724383722938, "Azotaemia ": 2.006257349114239, "B-cell lymphoma ": 2.109318584747225, "Bacterial sepsis ": 2.7708975411929413, "Bipolar I disorder ": 4.966625361874993, "Bladder spasm ": 5.88492601916547, "Blood bilirubin increased ": 2.3804710663731603, "Blood disorder ": 7.340849029817821, "Blood potassium decreased ": 3.25666084427149, "Blood thyroid stimulating hormone abnormal ": 7.516104243376881, "Blood thyroid stimulating hormone decreased ": 2.865633780662524, "Blood thyroid stimulating hormone increased ": 2.6907482269227407, "Blood uric acid increased ": 6.849380935879915, "Brain abscess ": 2.833479219816101, "CD4 lymphocytes decreased ": 4.0338954823160815, "Cardiomyopathy ": 2.1187359744430783, "Cellulitis ": 2.522573468139489, "Cerebellar infarction ": 4.459796079300907, "Cerebral haemorrhage ": 2.540970976298055, "Cerebral infarction ": 2.8655319410860622, "Chapped lips ": 2.800322583820305, "Cholecystectomy ": 2.655286764176956, "Chronic inflammatory demyelinating polyradiculoneuropathy ": 4.511070856971684, "Colitis ischaemic ": 11.214496666626587, "Connective tissue disorder ": 11.53237051439903, "Coombs positive haemolytic anaemia ": 11.21888842208301, "Cryoglobulinaemia ": 28.02724341520697, "Cutaneous sarcoidosis ": 8.350869435698465, "Deafness ": 2.2004023581835623, "Deafness neurosensory ": 2.7178549290624803, "Decreased appetite ": 3.267920827939701, "Decreased immune responsiveness ": 3.022503091221117, "Dehydration ": 3.4292589433707006, "Delusion ": 2.635276954199362, "Depression ": 4.686396471036185, "Depressive symptom ": 18.02828028460847, "Diabetes mellitus ": 4.677338784516457, "Diabetic ketosis ": 6.195044171748146, "Disseminated intravascular coagulation ": 2.8599875684713667, "Drug eruption ": 4.672010911985311, "Drug exposure before pregnancy ": 8.69825360655664, "Dry mouth ": 2.065606381219386, "Dry skin ": 3.585168494221376, "Dysgeusia ": 4.881739417072375, "Eczema asteatotic ": 8.603176086683266, "Encephalopathy ": 2.280285349255256, "Enteritis infectious ": 8.562411264644265, "Enterocolitis haemorrhagic ": 2.1140361391768483, "Erythema multiforme ": 3.441690826109807, "Escherichia sepsis ": 2.268377086942889, "Exposure via body fluid ": 27.624750342598524, "Facial paralysis ": 2.5092059960530646, "Feeding disorder ": 2.0230253038636388, "Fluid intake reduced ": 2.172692381010178, "Fluid replacement ": 15.2184793924201, "Gastrointestinal infection ": 3.210533593246148, "Gingival bleeding ": 3.036156598972957, "Goitre ": 3.4144234193954053, "Granulocytopenia ": 2.4157308133168165, "Graves' disease ": 12.593643762371324, "Haematocrit decreased ": 2.933802179443729, "Haemoglobin abnormal ": 2.26491664928827, "Haemoglobin decreased ": 7.68179900267006, "Haemolysis ": 2.482441073657569, "Haemolytic anaemia ": 7.391910526407071, "Haemorrhagic cerebral infarction ": 6.815147075760715, "Haemorrhoidal haemorrhage ": 2.5254171607097837, "Hair texture abnormal ": 2.5563502465571144, "Hepatic artery stenosis ": 65.52921356671662, "Hepatic cancer ": 2.160604981712785, "Hepatic cirrhosis ": 6.160783178397923, "Hepatic encephalopathy ": 6.377218557353179, "Hepatic failure ": 2.241652016966446, "Hepatic fibrosis ": 3.994828936692246, "Hepatic mass ": 3.5459208449778123, "Hepatic neoplasm ": 3.539833829639244, "Hepatic pain ": 4.081818816527785, "Hepatitis C ": 5.7032020278508, "Hepatitis C RNA increased ": 18.03834365547028, "Hepatocellular carcinoma ": 2.463860480363384, "Hepatorenal syndrome ": 5.677108487319266, "Homicidal ideation ": 16.966296080411045, "Homicide ": 10.86144446340948, "Hyaluronic acid increased ": 229.9380837770497, "Hypersensitivity pneumonitis ": 2.632444135533732, "Hyperthyroidism ": 8.831558827005379, "Hyperuricaemia ": 24.50673824102144, "Hypoacusis ": 3.0076588118825054, "Hypoalbuminaemia ": 2.078539569897931, "Hypothyroidism ": 5.864273946906122, "Immune thrombocytopenia ": 2.62063852971095, "Infection reactivation ": 14.047558024561583, "Influenza like illness ": 2.0285873433263046, "Injection site abscess ": 9.707400605901418, "Injection site cellulitis ": 13.684776272772432, "Injection site discolouration ": 3.286596304190232, "Injection site infection ": 6.618334975687935, "Injection site necrosis ": 41.4015605968823, "Injection site rash ": 5.529265529774063, "Injection site reaction ": 2.814292652181166, "Injection site ulcer ": 54.40757624041827, "Injection site vesicles ": 2.89159128554541, "Insomnia ": 2.478233936671585, "Interstitial lung disease ": 5.369333950365591, "Intervertebral discitis ": 5.502203486851474, "Intracranial aneurysm ": 4.749091614008878, "Irritability ": 3.651052494354712, "Jaundice ": 2.387202274608553, "Lacunar infarction ": 2.118287269868794, "Leukopenia ": 5.24453041822838, "Lip dry ": 2.605827300433849, "Liver transplant ": 6.172533444558133, "Liver transplant rejection ": 6.073202179948938, "Lung infiltration ": 3.834235648844026, "Lymph node tuberculosis ": 6.254891066078447, "Lymphatic disorder ": 15.5253665329719, "Lymphoma ": 3.008843057415183, "Mallory-Weiss syndrome ": 5.054866311248769, "Malnutrition ": 2.100944198813491, "Mania ": 2.4160397795734907, "Mean cell volume increased ": 5.502575046946735, "Memory impairment ": 2.933787384267375, "Meningitis bacterial ": 3.074499234801986, "Mental disorder ": 3.084396250006178, "Mental status changes ": 3.210409064732784, "Mononeuropathy multiplex ": 13.961157350823347, "Mood altered ": 2.5368567787863925, "Mood swings ": 3.3228463373999326, "Muscle abscess ": 8.03650631955333, "Muscle atrophy ": 2.279827764167504, "Musculoskeletal disorder ": 3.5864156883165847, "Necrotising fasciitis ": 3.515391834048868, "Nervousness ": 2.281610054257478, "Neurosis ": 11.744435572666768, "Neutropenia ": 2.937445766229771, "Neutrophil count decreased ": 3.182234615391523, "Non-cardiac chest pain ": 2.7152423874740137, "Normocytic anaemia ": 3.962046917388971, "Oesophageal varices haemorrhage ": 3.1623683826218723, "Optic ischaemic neuropathy ": 7.8836263184468995, "Optic nerve disorder ": 5.08671583400806, "Optic neuritis ": 5.74878954844395, "Optic neuropathy ": 8.783995469735185, "Pancreatic disorder ": 2.273628560753431, "Pancreatitis acute ": 2.2729548882269266, "Pancytopenia ": 4.301841055928266, "Papilloedema ": 6.061506012587965, "Paranoia ": 4.397214970717138, "Paternal exposure timing unspecified ": 9.640458377205611, "Peritoneal tuberculosis ": 20.86643233759957, "Peritonitis ": 2.3135606293766737, "Peritonitis bacterial ": 11.375328909316169, "Peroneal nerve palsy ": 4.7922438923996005, "Platelet count decreased ": 5.639694258630891, "Pleurisy ": 2.2881452715823616, "Pneumonia staphylococcal ": 4.110125124260783, "Polymyositis ": 4.003886628389784, "Portal vein thrombosis ": 2.114847633981307, "Proctalgia ": 2.199082126005491, "Product quality issue ": 3.8121735086498303, "Psoas abscess ": 8.689713970945844, "Psychiatric symptom ": 3.281670866273176, "Psychotic disorder ": 4.740014972610066, "Pulmonary sarcoidosis ": 8.498278330957756, "Pulmonary tuberculosis ": 3.2402997459025897, "Pyelonephritis ": 2.421579526196039, "Raynaud's phenomenon ": 2.2664341551497014, "Red blood cell count decreased ": 7.588078949916194, "Red blood cell transfusion ": 4.520038591047882, "Retinal artery occlusion ": 5.978729605743709, "Retinal artery thrombosis ": 16.190850188273497, "Retinal detachment ": 3.3842548095876235, "Retinal disorder ": 4.0169389983323285, "Retinal exudates ": 94.25267125992168, "Retinal haemorrhage ": 24.14369905346032, "Retinal ischaemia ": 22.977075856824367, "Retinal vascular thrombosis ": 5.725431121513322, "Retinal vein occlusion ": 11.679088892669055, "Retinal vein thrombosis ": 9.97927039068865, "Retinitis ": 4.925367400351732, "Retinopathy ": 30.705000610015883, "Sarcoidosis ": 14.531881927398729, "Sepsis ": 2.415427634791253, "Serum ferritin increased ": 2.072456724900973, "Sjogren's syndrome ": 2.178699722143336, "Skin disorder ": 2.459574525065867, "Skin necrosis ": 3.44230165991304, "Skin ulcer ": 2.3561383943173264, "Splenic infarction ": 2.61026036006261, "Spontaneous bacterial peritonitis ": 10.715034833200743, "Staphylococcal infection ": 2.660549738248412, "Staring ": 2.589372448623031, "Streptococcal infection ": 2.99569724684197, "Subarachnoid haemorrhage ": 3.3067832041759617, "Substance use ": 4.424820512520087, "Sudden hearing loss ": 5.70686964067958, "Suicidal ideation ": 3.1354626028712, "Thalamus haemorrhage ": 7.532296595928472, "Therapeutic product ineffective ": 7.002435721320284, "Thirst ": 2.452659173528025, "Thrombocytopenia ": 2.597146737202438, "Thrombotic thrombocytopenic purpura ": 4.25788171645187, "Thyroid disorder ": 3.411711297197196, "Thyroid function test abnormal ": 3.3548828495788072, "Thyroiditis ": 6.9752149101148815, "Tongue disorder ": 2.5842445354635366, "Tongue ulceration ": 3.4065075693555658, "Tooth abscess ": 2.4929345199523385, "Toxic skin eruption ": 2.357253317035293, "Transfusion ": 20.685621712119307, "Tuberculosis ": 2.0771039166099965, "Tuberculous pleurisy ": 10.374034978172435, "Tunnel vision ": 3.1594182052319075, "Type 1 diabetes mellitus ": 21.897156254167225, "Varices oesophageal ": 6.368217206785163, "Vasculitis ": 2.1351152580651007, "Violence-related symptom ": 3.662840562905101, "Viral load increased ": 3.5837865174260566, "Visual acuity reduced ": 2.2511329986056112, "Visual field defect ": 5.325001982935796, "Vogt-Koyanagi-Harada disease ": 25.70195007680612, "Weight decreased ": 4.432535373979823, "White blood cell count abnormal ": 3.894777321082533, "White blood cell count decreased ": 5.453411006971207} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/852.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/852.json new file mode 100644 index 00000000000..2c5fa8a6af0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/852.json @@ -0,0 +1 @@ +{"Drug ineffective ": 5.419638698076185, "Neutropenia ": 15.79702458550655} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/853.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/853.json new file mode 100644 index 00000000000..86b3b219d47 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/853.json @@ -0,0 +1 @@ +{"Accident ": 2.472498645656977, "Acute kidney injury ": 2.466616059031439, "Adenocarcinoma ": 13.406164798044175, "Adrenal insufficiency ": 12.209168077941726, "Adrenocorticotropic hormone deficiency ": 26.99864727474692, "Adverse event ": 3.387185153110514, "Anaemia ": 2.2395681729304133, "Atelectasis ": 2.228559301944032, "Atrioventricular block complete ": 3.719383453620359, "Autoimmune colitis ": 49.98372814426921, "Autoimmune haemolytic anaemia ": 11.953762954989994, "Autoimmune hepatitis ": 14.3734381364922, "Autoimmune hypothyroidism ": 86.8681272190973, "Autoimmune nephritis ": 77.26029267063099, "Autoimmune thyroiditis ": 11.73677481739524, "Blood thyroid stimulating hormone increased ": 5.545284949608902, "Bronchiectasis ": 2.298979924993493, "Cachexia ": 4.193654564646776, "Cardiac tamponade ": 4.039961880598208, "Central nervous system lesion ": 5.045507899970961, "Cholangitis ": 3.661618814149698, "Cholangitis sclerosing ": 16.05668030423402, "Cholecystitis ": 2.176121024718049, "Colitis ": 13.47612884143322, "Colitis microscopic ": 4.974813588076522, "Conjunctivitis ": 2.2779569168929434, "Cortisol decreased ": 11.87311502579998, "Cytokine release syndrome ": 3.161227625280937, "Cytopenia ": 2.721372608881852, "Dermatitis ": 3.59109310304366, "Dermatitis bullous ": 3.4839091246619787, "Diabetic ketoacidosis ": 5.312508188414273, "Drug effective for unapproved indication ": 15.535301193842452, "Drug-induced liver injury ": 3.328505832082729, "Eastern Cooperative Oncology Group performance status worsened ": 23.19455912006784, "Emphysema ": 2.35432785203974, "Encephalitis ": 5.745775811421783, "Encephalitis autoimmune ": 24.493644340755257, "Enterocolitis ": 3.135613259331224, "Eosinophilic fasciitis ": 70.56382415727057, "Eyelid ptosis ": 4.887155769292368, "Febrile neutropenia ": 3.438972151551652, "Fulminant type 1 diabetes mellitus ": 35.50521286446824, "Gastritis ": 2.207693137752005, "Gastrointestinal toxicity ": 4.179261713500728, "General physical health deterioration ": 2.876840895024185, "Groin pain ": 2.294625599913508, "Guillain-Barre syndrome ": 3.499112921541484, "Haematotoxicity ": 4.317666568753709, "Haemophagocytic lymphohistiocytosis ": 5.397512314161308, "Hepatitis ": 7.479720119548079, "Hepatitis toxic ": 3.7612757727925183, "Hepatotoxicity ": 6.909165705241249, "Hydronephrosis ": 3.827272070429225, "Hyperthyroidism ": 7.741051333738926, "Hypertransaminasaemia ": 9.423320697365924, "Hypophysitis ": 41.53316971573458, "Hypopituitarism ": 11.891688088871067, "Hypothyroidism ": 16.805180227366627, "Immune thrombocytopenia ": 3.804977470381414, "Immune-mediated adrenal insufficiency ": 12.18187611565332, "Immune-mediated adverse reaction ": 218.3804629883757, "Immune-mediated arthritis ": 225.4212119315721, "Immune-mediated dermatitis ": 110.2914143779514, "Immune-mediated encephalitis ": 88.13259325476984, "Immune-mediated enterocolitis ": 87.02014699375799, "Immune-mediated gastritis ": 138.76480206238105, "Immune-mediated hepatic disorder ": 17.702906219432123, "Immune-mediated hepatitis ": 159.59737572674177, "Immune-mediated hyperthyroidism ": 79.05340558283008, "Immune-mediated hypophysitis ": 68.77815117475505, "Immune-mediated hypothyroidism ": 108.51083532945196, "Immune-mediated lung disease ": 252.31174980586215, "Immune-mediated myasthenia gravis ": 142.78294347950708, "Immune-mediated myocarditis ": 222.96752296417367, "Immune-mediated myositis ": 163.0249869285506, "Immune-mediated nephritis ": 97.79539167654733, "Immune-mediated neuropathy ": 76.49009480494051, "Immune-mediated pancreatitis ": 106.91384188795674, "Immune-mediated renal disorder ": 41.03041589550981, "Immune-mediated thyroiditis ": 272.9409870106071, "Immune-mediated uveitis ": 87.25310306014602, "Inappropriate schedule of product administration ": 4.670820252626418, "Interstitial lung disease ": 3.30496325809951, "Intestinal perforation ": 2.306969561045507, "Lichen planus ": 8.72861911035164, "Lichenoid keratosis ": 15.455843731148954, "Lung adenocarcinoma ": 8.450147929399304, "Lung consolidation ": 7.839506423332576, "Lymphocytic hypophysitis ": 41.1719771148286, "Malignant neoplasm progression ": 22.544986335850417, "Metastases to adrenals ": 16.600920758504564, "Metastases to central nervous system ": 2.048016328557937, "Metastases to lung ": 2.1447424190208206, "Mucosal inflammation ": 5.08786367137818, "Multi-organ disorder ": 20.00576718863162, "Myasthenia gravis ": 26.215648034731014, "Myasthenia gravis crisis ": 30.418324473380853, "Myasthenic syndrome ": 33.76937177007655, "Myocarditis ": 5.851308603952155, "Myopathy ": 2.699496723212772, "Myositis ": 17.149963639662726, "Nephritis ": 31.09587608715112, "Nephropathy toxic ": 4.4615282099775095, "Neutropenia ": 2.759050502782986, "Neutropenic sepsis ": 4.578900562803577, "Non-small cell lung cancer ": 4.549050977466058, "Non-small cell lung cancer metastatic ": 35.32621984119697, "Ocular myasthenia ": 45.98025625679719, "Off label use ": 2.2260894039320007, "Ophthalmoplegia ": 8.032282111595299, "Organising pneumonia ": 12.523307405207756, "Palmar-plantar erythrodysaesthesia syndrome ": 2.6386768565817307, "Pancytopenia ": 3.2001865606127686, "Pemphigoid ": 17.85239913267581, "Performance status decreased ": 2.689200158241418, "Pericardial effusion ": 2.186758890047929, "Pleural effusion ": 2.375550063168703, "Pneumocystis jirovecii pneumonia ": 2.3491300736374656, "Pneumonitis ": 30.10659730805594, "Pneumothorax ": 2.01628070961675, "Polyarthritis ": 17.233569810920102, "Polymyalgia rheumatica ": 13.494303455996013, "Posterior reversible encephalopathy syndrome ": 3.855960667303973, "Prescribed underdose ": 3.812801396102118, "Primary hypothyroidism ": 87.03208616193082, "Product use in unapproved indication ": 5.701699506444728, "Product use issue ": 5.152339237576816, "Proteinuria ": 4.052773951805703, "Psoriasis ": 2.412262972984238, "Pulmonary fibrosis ": 2.3439105708916537, "Pulmonary toxicity ": 8.069315406345059, "Radiotherapy ": 31.937862675345663, "Rash maculo-papular ": 2.118334824169172, "Renal cyst ": 3.613544137050373, "Renal tubular necrosis ": 8.048350806156884, "Respiratory failure ": 2.1706551005134904, "Sarcoidosis ": 8.471164720858777, "Secondary adrenocortical insufficiency ": 18.566455566098043, "Sjogren's syndrome ": 8.423800994486738, "Skin infection ": 3.2701089129512866, "Skin toxicity ": 24.193048356096604, "Stevens-Johnson syndrome ": 2.8707566242744376, "Therapy non-responder ": 6.449377838043633, "Therapy partial responder ": 97.89781064909909, "Thyroiditis ": 18.04392353236316, "Toxic epidermal necrolysis ": 5.781953473209828, "Troponin increased ": 2.3393398088714794, "Tubulointerstitial nephritis ": 15.032409516279172, "Tumour hyperprogression ": 286.3694136234043, "Tumour pseudoprogression ": 184.13392856790887, "Type 1 diabetes mellitus ": 29.26185608868576, "Uveitis ": 3.437673698302169, "Vasculitis ": 2.9312153737948616, "Vitiligo ": 44.42715331401061} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/854.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/854.json new file mode 100644 index 00000000000..13167a82f22 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/854.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.4589991346483107, "Adenocarcinoma ": 29.411759205478, "Anaemia ": 8.254263839702183, "Blood creatinine increased ": 2.65723815982791, "Bone marrow failure ": 3.5571300506083587, "Cytopenia ": 8.661589289839752, "Decreased appetite ": 2.0597320403413653, "Disease progression ": 8.779625294981704, "Erysipelas ": 8.459825764561852, "Eyelid oedema ": 5.943825526776097, "Febrile bone marrow aplasia ": 26.772052895399803, "Febrile neutropenia ": 9.213016454774568, "Fluid retention ": 2.3767697755699704, "Gastrointestinal toxicity ": 15.46480298601168, "General physical health deterioration ": 2.038273245465963, "Glomerular filtration rate decreased ": 2.3813590387932786, "Haematotoxicity ": 59.72475605556156, "Haemoglobin decreased ": 2.1430363265182244, "Haemoptysis ": 4.260469760728439, "Hepatic function abnormal ": 4.0343043886864685, "Hepatotoxicity ": 8.437011960379898, "Hypercreatininaemia ": 55.48299098868674, "Hypertransaminasaemia ": 6.8597886032104185, "Interstitial lung disease ": 3.037791356837816, "Kidney fibrosis ": 29.308097536992346, "Lacrimation increased ": 2.560465838973916, "Leukopenia ": 7.476794303000054, "Liver injury ": 2.278333507171818, "Lung adenocarcinoma ": 86.98840776426681, "Lung adenocarcinoma stage IV ": 142.9284234042745, "Malignant neoplasm progression ": 20.37061834568109, "Metastases to bone ": 3.4453514551195266, "Metastases to central nervous system ": 6.874710134936829, "Metastases to liver ": 2.6483612872406144, "Metastases to lung ": 3.569441367978779, "Mouth ulceration ": 2.584181272144885, "Mucosal inflammation ": 7.7321859486767535, "Myelosuppression ": 44.96270929325553, "Neoplasm progression ": 5.898010270704583, "Nephropathy toxic ": 17.20789078806694, "Neutropenia ": 10.085150629041744, "Neutropenic colitis ": 26.199465956507265, "Neutropenic sepsis ": 15.810092617644823, "Neutrophil count decreased ": 10.364620404842864, "Non-small cell lung cancer ": 29.84811142501192, "Oedema peripheral ": 2.0148124283467843, "Off label use ": 2.1542632275926006, "Osteonecrosis of jaw ": 4.687289583030724, "Ototoxicity ": 31.348768565678352, "Pancytopenia ": 10.621235728969689, "Peripheral ischaemia ": 11.482248470918138, "Platelet count decreased ": 6.5236565887887, "Pleural effusion ": 2.607980512916922, "Pneumonia ": 2.149662413314887, "Pneumonitis ": 7.623794091325042, "Pneumothorax ": 2.871185898940192, "Proteinuria ": 2.8281726182896776, "Pseudocellulitis ": 1527.0649025067391, "Pulmonary toxicity ": 7.914760144598592, "Renal impairment ": 4.191925576994509, "Renal tubular necrosis ": 13.187362614981147, "Respiratory failure ": 4.325437726915787, "Scleroderma ": 22.765918159140377, "Sepsis ": 2.422509859981268, "Skin hyperpigmentation ": 7.596153956270079, "Skin toxicity ": 16.728436226166863, "Therapeutic response decreased ": 2.603158947398427, "Therapy partial responder ": 19.845889263031644, "Thrombocytopenia ": 6.064010459598344, "Toxic epidermal necrolysis ": 3.070247010802734, "Treatment failure ": 2.949165635338668, "Tubulointerstitial nephritis ": 7.006932152896293, "White blood cell count decreased ": 7.598839570149743} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/855.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/855.json new file mode 100644 index 00000000000..753d3855c01 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/855.json @@ -0,0 +1 @@ +{"Aggression ": 33.183438752010844, "Altered state of consciousness ": 12.23001555370216, "Anger ": 33.01116502743489, "Balance disorder ": 7.2792627732616015, "Drug interaction ": 5.968937727079735, "Epilepsy ": 15.057648403573708, "Gait disturbance ": 3.9467880703460914, "Intentional overdose ": 9.741663556189955, "Irritability ": 17.189651770743307, "Multiple-drug resistance ": 151.4527106111148, "Off label use ": 2.142332320174703, "Partial seizures ": 45.44369259789571, "Pneumonia aspiration ": 20.82629814709234, "Product use in unapproved indication ": 3.702873554639356, "Seizure ": 5.877154859472207, "Somnolence ": 3.51008302730924, "Suicidal ideation ": 4.93186003540748, "Suicide attempt ": 8.905146422301383} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/856.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/856.json new file mode 100644 index 00000000000..129ae13b55f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/856.json @@ -0,0 +1 @@ +{"Anaphylactic reaction ": 5.249903384308326, "Anaphylactic shock ": 5.335533042116636, "Blood pressure increased ": 2.3280484829120605, "Bone pain ": 2.049112437286263, "Cardiac failure ": 4.754201012928661, "Chest discomfort ": 2.7412139608184813, "Death ": 4.665329894546545, "Dehydration ": 2.466418119290907, "Diarrhoea ": 4.829383774564465, "Disease progression ": 6.933375395934014, "Dyspnoea ": 2.214366326172601, "Ejection fraction decreased ": 18.93911789607467, "Febrile neutropenia ": 4.567332124354529, "Flushing ": 6.53996650230572, "Heart rate increased ": 2.0255045571431425, "Hyperpyrexia ": 6.544825074071549, "Hypersensitivity ": 4.506661707713622, "Infusion related reaction ": 22.759051600025884, "Interstitial lung disease ": 2.9442108924753807, "Leukopenia ": 2.3851098462010696, "Metastases to central nervous system ": 10.500135282061494, "Myelosuppression ": 10.975652294960303, "Neuropathy peripheral ": 2.2974886740037377, "Neutropenia ": 3.101452895956794, "Neutrophil count decreased ": 6.887184139759491, "Oxygen saturation decreased ": 8.046205184682673, "Respiratory distress ": 2.9171843994845124, "Tachycardia ": 2.4274643492201573, "White blood cell count decreased ": 5.92307378257393} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/857.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/857.json new file mode 100644 index 00000000000..ba9b047fa06 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/857.json @@ -0,0 +1 @@ +{"Cardiac failure ": 7.725287309307281, "Cardiotoxicity ": 55.73073659640681, "Diarrhoea ": 3.242182744686482, "Disease progression ": 8.543077741966828, "Ejection fraction decreased ": 75.59941775510055, "Febrile neutropenia ": 17.226346395835417, "Flushing ": 4.300065078677275, "Infusion related reaction ": 10.059885656161416, "Left ventricular dysfunction ": 37.70973436625419, "Leukopenia ": 3.2880506145431565, "Metastases to central nervous system ": 16.292755740890993, "Myelosuppression ": 21.30114627392455, "Neuropathy peripheral ": 5.842784754656542, "Neutropenia ": 9.378346503749755, "Neutrophil count decreased ": 10.451775582788557, "Off label use ": 2.626503223305213, "Renal impairment ": 2.857344746851234, "White blood cell count decreased ": 4.636403099802152} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/858.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/858.json new file mode 100644 index 00000000000..3dcc84565ef --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/858.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 2.081425096886747, "Cardio-respiratory arrest ": 6.227740874401152, "Completed suicide ": 14.62938634371715, "Drug interaction ": 2.612723980660734, "Hallucination, visual ": 65.54495287783573, "Hepatic enzyme increased ": 2.19872677036686, "Hyperglycaemia ": 2.5777670484436626, "Hyperthyroidism ": 57.903364911478015, "Hypoglycaemia ": 16.123977300365524, "Hypoglycaemic coma ": 27.96394571728185, "Influenza ": 10.12611224470729, "Intentional overdose ": 5.9082427349603925, "Neutropenia ": 7.91768885037507, "Renal impairment ": 2.5590417102822065, "Shock ": 12.637787872803091, "Suspected suicide ": 32.93100537419011, "Toxicity to various agents ": 3.657993130570947, "Type 2 diabetes mellitus ": 80.67181806877197, "Weight increased ": 5.19238448640317, "White blood cell count decreased ": 14.337367824150247, "White blood cell count increased ": 6.863550994172742} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/859.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/859.json new file mode 100644 index 00000000000..d0a367b5fe3 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/859.json @@ -0,0 +1 @@ +{"Blood glucose increased ": 12.713191127032475, "Breast cancer ": 5.626746484333479, "Breast cancer metastatic ": 43.98467014680431, "Colitis ": 6.025353199249127, "Dehydration ": 2.3588537905735776, "Diabetes mellitus ": 9.45279038400892, "Diabetic ketoacidosis ": 18.280216893171648, "Diarrhoea ": 3.851986577253494, "Disease progression ": 3.2311302779948297, "Hyperglycaemia ": 90.6698687634995, "Hyperglycaemic hyperosmolar nonketotic syndrome ": 217.3686244158599, "Ketoacidosis ": 20.65949515863162, "Malignant neoplasm progression ": 10.087116948684503, "Metastases to liver ": 9.271530529835005, "Mucosal inflammation ": 7.152458026021125, "Off label use ": 2.7299149608412363, "Rash ": 8.382434411308836, "Stomatitis ": 6.4326821372027245, "Weight decreased ": 2.088678424041207} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/86.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/86.json new file mode 100644 index 00000000000..96a2a1811a0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/86.json @@ -0,0 +1 @@ +{"Toxicity to various agents ": 34.113043035237474} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/860.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/860.json new file mode 100644 index 00000000000..f98f8eea10b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/860.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 2.295053504635189, "Adverse drug reaction ": 21.581837887027127, "Adverse reaction ": 48.55819001664136, "Bronchiectasis ": 21.00905712958486, "Cerebrovascular accident ": 2.394732718545204, "Cough ": 3.541896485043054, "Death ": 3.5399156404638354, "Decreased appetite ": 7.512051753676739, "Drug intolerance ": 2.557877738884144, "Dyspepsia ": 2.375431447975917, "Erythema ": 2.533073561078234, "Forced vital capacity decreased ": 405.76837801449045, "Gastrointestinal disorder ": 3.178118821584988, "Hypoxia ": 4.280869916629347, "Idiopathic pulmonary fibrosis ": 166.8642218539805, "Illness ": 8.242357090670469, "Interstitial lung disease ": 4.001933157703228, "Lower respiratory tract infection ": 7.363690924686139, "Oxygen saturation decreased ": 5.823960767821354, "Photosensitivity reaction ": 81.87302339553328, "Pneumonia ": 2.44732457716062, "Pulmonary function test decreased ": 46.75724283173488, "Rash ": 2.2413771349890736, "Transaminases increased ": 3.3914089065389272, "Weight decreased ": 6.143638566505758} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/861.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/861.json new file mode 100644 index 00000000000..fc0d2a03e30 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/861.json @@ -0,0 +1 @@ +{"Abdominal wall haematoma ": 6.28994304063291, "Acquired haemophilia ": 3.172403983703888, "Activated partial thromboplastin time prolonged ": 2.432589292809432, "Acute coronary syndrome ": 3.9878396818999975, "Acute myocardial infarction ": 5.3238830434327, "Agranulocytosis ": 4.914840252785733, "Anaemia ": 6.169419127117733, "Aneurysm ": 2.783163353400479, "Angina pectoris ": 4.223473972436615, "Angina unstable ": 8.81379350964742, "Angiopathy ": 3.764565025197937, "Angioplasty ": 3.645819862662734, "Aortic aneurysm ": 4.924655058951651, "Aortic valve disease ": 3.2401241714763445, "Aplastic anaemia ": 4.213671247983228, "Arterial disorder ": 2.1811583509497425, "Arterial haemorrhage ": 6.355952011316006, "Arterial occlusive disease ": 4.987798560949623, "Arterial restenosis ": 47.25363266924098, "Atrial fibrillation ": 2.1074601914480384, "Barrett's oesophagus ": 5.1052873628851945, "Bladder neoplasm ": 5.681022915342981, "Bleeding time prolonged ": 13.806287259183332, "Blood cholesterol decreased ": 6.074325505852805, "Blood disorder ": 2.44863060689101, "Blood iron decreased ": 2.2096870435447684, "Blood loss anaemia ": 29.43288107468145, "Blood urine present ": 3.772079829271092, "Bloody discharge ": 4.297140245820985, "Brain herniation ": 4.35350699944449, "Brain stem haemorrhage ": 9.950861928007686, "Cardiac fibrillation ": 4.203533454656158, "Cardiac operation ": 2.083659650300775, "Cardiac pacemaker insertion ": 3.981885956921984, "Cardiac ventricular thrombosis ": 2.288216277309869, "Carotid artery occlusion ": 7.949387345977489, "Carotid artery stenosis ": 2.026510596699157, "Catheter site haematoma ": 79.02445855326559, "Catheter site haemorrhage ": 7.309961457209004, "Cerebellar haematoma ": 16.47518721007987, "Cerebellar haemorrhage ": 10.645445404572689, "Cerebral haematoma ": 26.294385903518837, "Cerebral haemorrhage ": 22.115280497227296, "Cerebral infarction ": 3.1488466332521177, "Cerebral mass effect ": 5.778248954039571, "Cerebrovascular accident ": 6.141716358074126, "Cholestatic liver injury ": 2.6432378196066355, "Chronic gastritis ": 4.165668029460797, "Coagulation time prolonged ": 3.3581803388588307, "Coagulopathy ": 5.12737158090706, "Colitis ischaemic ": 2.405394736046309, "Compartment syndrome ": 2.3402767808434057, "Conjunctival haemorrhage ": 8.764617160620695, "Contusion ": 4.908728369407085, "Coronary arterial stent insertion ": 7.942217765510513, "Coronary artery disease ": 2.4728509277392035, "Coronary artery occlusion ": 23.35166740383886, "Coronary artery restenosis ": 33.19882751125416, "Coronary artery stenosis ": 6.49371448584202, "Coronary artery thrombosis ": 13.131033253766349, "Decubitus ulcer ": 2.066303273499224, "Deformity ": 3.644726580040652, "Dermatitis exfoliative ": 2.6214398934785423, "Dermatitis exfoliative generalised ": 3.0306962728208697, "Device occlusion ": 12.190020800317544, "Dieulafoy's vascular malformation ": 28.778328679139065, "Discoloured vomit ": 6.5218593584853695, "Diverticulitis intestinal haemorrhagic ": 29.5160022152292, "Diverticulum ": 2.6408760654630403, "Diverticulum intestinal haemorrhagic ": 31.835245275498075, "Drug interaction ": 2.7165233277278413, "Duodenal ulcer ": 12.413672636828542, "Duodenal ulcer haemorrhage ": 28.28715668362136, "Duodenitis ": 5.498682416117826, "Dysgraphia ": 2.432414536987068, "Ear haemorrhage ": 9.300917612588314, "Ecchymosis ": 8.819045324516733, "Embolic stroke ": 4.020423737633144, "Enterocolitis haemorrhagic ": 2.533554145891677, "Eosinophilic pneumonia ": 2.7188848092557523, "Epistaxis ": 10.48132167463632, "Erosive duodenitis ": 14.104380110500095, "Erosive oesophagitis ": 4.324117920289487, "Erythema multiforme ": 2.1051280324286297, "Extradural haematoma ": 14.325601460742062, "Eye haemorrhage ": 9.721068054294289, "Faeces discoloured ": 10.375083645609507, "Gastric haemorrhage ": 22.330132128091737, "Gastric mucosal lesion ": 5.215361841865585, "Gastric ulcer ": 12.071694248665333, "Gastric ulcer haemorrhage ": 34.883538878970114, "Gastric ulcer perforation ": 4.852684293276983, "Gastritis ": 3.897352625413544, "Gastritis erosive ": 12.56743173742952, "Gastritis haemorrhagic ": 16.090567457107856, "Gastrointestinal haemorrhage ": 58.14072678754583, "Gastrointestinal polyp haemorrhage ": 18.225551095337597, "Gastrointestinal ulcer ": 10.108990527443789, "Gastrointestinal ulcer haemorrhage ": 29.122399363631228, "Gastrointestinal vascular malformation haemorrhagic ": 63.69759577999172, "Gingival bleeding ": 8.888100807556258, "Granulocytopenia ": 4.277655841332218, "Haemarthrosis ": 3.708443549757176, "Haematemesis ": 17.439718897034922, "Haematochezia ": 7.555389457139873, "Haematocrit decreased ": 3.330966251613269, "Haematoma ": 8.820475291757107, "Haematoma muscle ": 9.283363490721277, "Haematuria ": 12.126307237353275, "Haemobilia ": 8.634130011881549, "Haemoglobin decreased ": 4.203883964242581, "Haemoperitoneum ": 6.824813963704834, "Haemoptysis ": 8.711071841550929, "Haemorrhage ": 15.74756841204318, "Haemorrhage intracranial ": 13.366081867265708, "Haemorrhage subcutaneous ": 31.575018865403024, "Haemorrhage urinary tract ": 12.316908246133815, "Haemorrhagic arteriovenous malformation ": 159.1499442552488, "Haemorrhagic cerebral infarction ": 9.178141916272528, "Haemorrhagic diathesis ": 11.20542355451585, "Haemorrhagic erosive gastritis ": 17.458051117642274, "Haemorrhagic stroke ": 29.191157039294648, "Haemorrhagic transformation stroke ": 21.71508144073877, "Haemorrhoidal haemorrhage ": 12.933937152801573, "Haemothorax ": 8.13287277779388, "Head injury ": 2.0672421933858205, "Hemiparesis ": 2.916338004213289, "Hemiplegia ": 5.544016957274099, "Hepatic function abnormal ": 2.2849152445377507, "Hepatitis fulminant ": 2.5274009662209256, "Hepatocellular injury ": 2.4162069549370897, "Hernia repair ": 2.7759190970341665, "Hiatus hernia ": 2.2823871712581205, "Hypochromic anaemia ": 4.375159934178359, "Hypovolaemic shock ": 5.373140518859981, "Implant site fibrosis ": 66.67846209606256, "Incision site haemorrhage ": 11.315875907389444, "Increased tendency to bruise ": 6.002860946020523, "Injury ": 3.6589711094991326, "Internal haemorrhage ": 22.00420456040948, "International normalised ratio abnormal ": 2.389411160153802, "International normalised ratio decreased ": 2.622995884057844, "International normalised ratio fluctuation ": 3.312278737729205, "International normalised ratio increased ": 3.953282338771351, "Interstitial lung disease ": 2.006127152272874, "Intestinal haemorrhage ": 8.89784697878515, "Intra-abdominal haematoma ": 9.32629301844029, "Intra-abdominal haemorrhage ": 8.211581888668155, "Intracranial aneurysm ": 4.169441733018772, "Intracranial haematoma ": 19.375652686918187, "Intraventricular haemorrhage ": 12.696408752265803, "Iron deficiency anaemia ": 6.184302645079456, "Ischaemic stroke ": 5.542897982559905, "Jaundice ": 2.095808299797725, "Labelled drug-drug interaction issue ": 12.721136889703276, "Labelled drug-drug interaction medication error ": 21.651846697026063, "Large intestinal haemorrhage ": 15.846210390817337, "Large intestinal ulcer ": 2.461264012467892, "Lip erosion ": 3.278526683660457, "Loss of employment ": 9.382258376442618, "Lower gastrointestinal haemorrhage ": 33.28197483813736, "Mallory-Weiss syndrome ": 10.190047385489, "Melaena ": 28.27726551692328, "Meningorrhagia ": 20.7498074890058, "Microcytic anaemia ": 7.310789076838037, "Mouth haemorrhage ": 8.651168684259495, "Mucosal haemorrhage ": 3.659441874727186, "Multiple injuries ": 352.4772273286153, "Muscle haemorrhage ": 9.421461851994469, "Myocardial infarction ": 5.375368047075587, "Non-cardiac chest pain ": 2.1682345078921483, "Normochromic normocytic anaemia ": 2.1963222721546933, "Normocytic anaemia ": 4.639052070488683, "Occult blood positive ": 23.09045927506125, "Oesophageal disorder ": 2.7366045691650527, "Oesophageal haemorrhage ": 19.13280329807113, "Oesophageal ulcer ": 7.309920750555538, "Oesophageal ulcer haemorrhage ": 19.72427474693973, "Oesophagitis ": 3.2582806962705613, "Oesophagitis ulcerative ": 16.360918015580044, "Pelvic haematoma ": 9.703096181327036, "Peptic ulcer ": 4.693988125896942, "Peptic ulcer haemorrhage ": 27.74344239253145, "Pericardial haemorrhage ": 14.51154824823795, "Periorbital haematoma ": 11.850185208903696, "Peripheral arterial occlusive disease ": 4.547100305217328, "Peripheral artery occlusion ": 6.299287492240356, "Petechiae ": 2.707744136286437, "Pharyngeal haemorrhage ": 4.91471827264757, "Pharyngeal ulceration ": 5.654245672630367, "Physical disability ": 8.682241137144018, "Platelet function test abnormal ": 51.65079099407865, "Polyp ": 2.2464824514100585, "Poor peripheral circulation ": 2.338066155825059, "Post procedural haematoma ": 15.375998685287408, "Post procedural haemorrhage ": 22.005186251289697, "Potentiating drug interaction ": 2.329421002551059, "Prescribed overdose ": 4.576202617219796, "Procedural haemorrhage ": 9.988297316909538, "Product counterfeit ": 24.487052627680413, "Prothrombin level decreased ": 2.0910749344927826, "Prothrombin time prolonged ": 3.488216579291176, "Psychological trauma ": 36.87053850096279, "Pulmonary alveolar haemorrhage ": 3.4027531918162035, "Pulmonary haemorrhage ": 5.6282966646416615, "Puncture site haemorrhage ": 10.865019481166508, "Purpura ": 4.32140517014488, "Putamen haemorrhage ": 9.19892587962771, "Rebound effect ": 2.2488448511020303, "Rectal haemorrhage ": 20.238873400085225, "Renal artery stenosis ": 4.385696259218197, "Renal haematoma ": 13.70401063190136, "Renal haemorrhage ": 8.94223423357372, "Respiratory tract haemorrhage ": 11.714670556254262, "Retinal haemorrhage ": 8.532573482211335, "Retroperitoneal haematoma ": 11.33185287564944, "Retroperitoneal haemorrhage ": 16.624812849855513, "Serum sickness ": 2.773883560134318, "Shock haemorrhagic ": 19.310729220045054, "Skin haemorrhage ": 5.331956820961318, "Small intestinal haemorrhage ": 11.541507891939714, "Social problem ": 5.501297041371289, "Spinal cord haematoma ": 11.912684503082938, "Spinal epidural haematoma ": 4.902329017024855, "Splenic haemorrhage ": 15.067286629194433, "Spontaneous haematoma ": 5.386888734547451, "Stent malfunction ": 29.02105724509085, "Stent placement ": 12.499347093002909, "Subarachnoid haemorrhage ": 12.19462490815097, "Subcutaneous haematoma ": 10.83445632794738, "Subdural haematoma ": 30.88754166314978, "Subdural haemorrhage ": 15.223391912779832, "Suspected counterfeit product ": 5.929053760194957, "Tension ": 3.7976619066512503, "Thalamus haemorrhage ": 11.22157820880138, "Thrombocytopenia ": 2.8054441316982617, "Thrombocytopenic purpura ": 11.594030724354718, "Thrombosis ": 2.866722261456152, "Thrombosis in device ": 35.79999473605581, "Thrombotic thrombocytopenic purpura ": 68.76039314357067, "Tongue haemorrhage ": 7.997916733861288, "Toxic skin eruption ": 2.7612730998833723, "Transient ischaemic attack ": 6.969541862351431, "Traumatic haematoma ": 20.201368983726788, "Traumatic haemorrhage ": 10.825895147601576, "Traumatic intracranial haemorrhage ": 25.100812869438226, "Tumour haemorrhage ": 2.688830446313793, "Ulcer ": 4.05031424190119, "Ulcer haemorrhage ": 231.8802514471334, "Upper gastrointestinal haemorrhage ": 34.89233105922272, "Urethral haemorrhage ": 9.160502241040277, "Urinary bladder haemorrhage ": 14.492368530081992, "Uterine haemorrhage ": 2.460827862492041, "Vascular graft ": 6.808008210158391, "Vascular occlusion ": 17.49389637437199, "Vascular pseudoaneurysm ": 20.764356914504603, "Vascular stent occlusion ": 54.43452760316192, "Vascular stent stenosis ": 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\ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/870.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/870.json new file mode 100644 index 00000000000..ccc20e101eb --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/870.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 2.1297187683257275, "Aspergillus infection ": 30.36901757396796, "Blood bilirubin increased ": 2.3390358965387645, "Bronchopulmonary aspergillosis ": 13.653872966793005, "Candida infection ": 13.488552157105609, "Cholestasis ": 5.063814515427367, "Condition aggravated ": 2.6823732668275038, "Disease progression ": 3.227390373072085, "Drug ineffective ": 5.585096023072153, "Drug ineffective for unapproved indication ": 10.785472909912825, "Drug interaction ": 16.904420404916365, "Drug level below therapeutic ": 86.68917342704319, "Drug level decreased ": 18.90997515650169, "Drug level increased ": 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index 00000000000..d508445521a --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/872.json @@ -0,0 +1 @@ +{"Activated partial thromboplastin time prolonged ": 24.961551686533923, "Acute kidney injury ": 5.163366593166926, "Acute myocardial infarction ": 2.397096144436281, "Anaemia ": 4.271629460159758, "Atrial fibrillation ": 5.063531688034881, "Atrial flutter ": 9.031644623877863, "Blood loss anaemia ": 35.61284548976116, "Cardiac arrest ": 2.631377587274264, "Cardiac failure ": 3.289042336680393, "Cardio-respiratory arrest ": 2.5605745715425776, "Cerebral haematoma ": 11.21386438796598, "Cerebral haemorrhage ": 6.267278424431333, "Cerebral infarction ": 2.0183107372755544, "Cerebrovascular accident ": 3.0720222914856365, "Coagulopathy ": 29.09194849269363, "Contusion ": 2.201419407419697, "Drug interaction ": 4.688270490969302, "Embolic stroke ": 19.751723426223187, "Epistaxis ": 3.754822060273004, "Faeces discoloured ": 3.6572667401456633, "Fall 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/873.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/873.json new file mode 100644 index 00000000000..f611df9cddd --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/873.json @@ -0,0 +1 @@ +{"Myalgia ": 2.5189684738246845} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/874.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/874.json new file mode 100644 index 00000000000..c7e1cb0297f --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/874.json @@ -0,0 +1 @@ +{"Abdominal discomfort ": 3.025812279689638, "Condition aggravated ": 2.5570218399762155, "Hallucination ": 20.583403914815182, "Hyperhidrosis ": 3.4731125668744016, "Insomnia ": 2.9811683868457397, "Oedema peripheral ": 11.577403354098026, "Off label use ": 2.088606678539077, "Product use in unapproved indication ": 3.251001727753705, "Somnolence ": 6.535247268881274, "Suicidal ideation ": 5.748310049704841} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/875.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/875.json new file mode 100644 index 00000000000..5fba75b1b97 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/875.json @@ -0,0 +1 @@ +{"Blood glucose increased ": 8.331648465286401, "Hypoglycaemia ": 13.256137182522496, "Hypoglycaemic coma ": 104.73430579604802} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/876.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/876.json new file mode 100644 index 00000000000..6cc3d5ed720 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/876.json @@ -0,0 +1 @@ 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23.09488376151867, "Frequent bowel movements ": 16.29850977187622, "Full blood count abnormal ": 3.678880157178435, "Haematochezia ": 5.211406089267794, "Hallucination, visual ": 2.5856107724894604, "Hepatic cytolysis ": 2.127093626981684, "Hepatic steatosis ": 3.58156528209786, "Hormone level abnormal ": 3.23126701580303, "Hypercapnia ": 8.025811553870865, "Hypothermia ": 2.254572635668405, "Hypovolaemia ": 3.4382222589754106, "Impaired driving ability ": 3.151123067066041, "Inadequate analgesia ": 16.694727020514254, "Infusion related reaction ": 5.042370566723563, "Intentional overdose ": 4.761976522278563, "Intentional product misuse ": 7.825524793513819, "Intentional self-injury ": 4.461698494727343, "Iron deficiency ": 11.36202917709176, "Lip discolouration ": 45.517006873899646, "Metabolic disorder ": 4.542569620838044, "Middle insomnia ": 10.034790778955744, "Miosis ": 16.05252066141492, "Multiple sclerosis ": 2.3627923084863034, "Muscle tightness ": 3.4329693007340705, 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/879.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/879.json new file mode 100644 index 00000000000..3a27c2f9af0 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/879.json @@ -0,0 +1 @@ +{"Blood alkaline phosphatase increased ": 23.79542210462477, "Blood calcium increased ": 121.49477305195362, "Decreased appetite ": 2.297170738181346, "Hypercalcaemia ": 273.23643781903644, "Nausea ": 2.5397828714246398, "Palpitations ": 3.195143846090982, "Spinal fracture ": 50.47369314178402, "Weight decreased ": 5.452312202527639} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/88.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/88.json new file mode 100644 index 00000000000..f8931503001 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/88.json @@ -0,0 +1 @@ +{"Completed suicide ": 10.70798892837862, "Drug dependence ": 17.39829051045501, "Overdose ": 7.557112045353668, "Substance abuse ": 90.91997633762354} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/880.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/880.json new file mode 100644 index 00000000000..843608032c5 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/880.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 19.842860680126417, "Aspartate aminotransferase increased ": 20.78805621349088, "Electrocardiogram QT prolonged ": 22.08900263208421} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/881.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/881.json new file mode 100644 index 00000000000..3b0014691bf --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/881.json @@ -0,0 +1 @@ +{"Abnormal behaviour ": 2.0316697162902413, "Allergy to metals ": 103.4896340748829, "Anaphylactic reaction ": 2.6719949065830777, "Apathy ": 3.4146565422771413, "Apnoea ": 19.58757845662804, "Autism spectrum disorder ": 28.46206393260012, "Cardio-respiratory arrest ": 2.119375581134088, "Choking ": 3.440455028525097, "Conjunctivitis ": 5.461493573092191, "Crying ": 30.895838871539688, "Cyanosis ": 14.652702315393851, "Decreased appetite ": 2.096611770759232, "Developmental delay ": 8.455937997491173, "Dyskinesia ": 2.690482314826129, "Eczema ": 2.9660772002206333, "Erythema ": 2.3628016484197567, "Erythema multiforme ": 3.523600250929058, "Eye movement disorder ": 6.301527756001803, "Febrile convulsion ": 58.6699166913204, "Flatulence ": 2.615509628668609, "Gastroenteritis ": 5.923794995236322, "Gastroenteritis rotavirus ": 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11.787694360646636, "Purpura ": 6.663251033504417, "Pyrexia ": 3.4804902135149423, "Rash ": 2.0251166961042397, "Rash macular ": 3.7838574689351647, "Rash maculo-papular ": 2.4936435357451887, "Rash morbilliform ": 10.694546844844876, "Reaction to excipient ": 27.390414591103124, "Respiratory arrest ": 3.918616804685032, "Restlessness ": 8.435183808845776, "Rhinorrhoea ": 5.32850482029045, "Scratch ": 19.639214333628622, "Screaming ": 33.56137946092968, "Seizure ": 3.892739271317128, "Skin wound ": 46.76304399660237, "Speech disorder developmental ": 20.707825926869564, "Staring ": 17.586787577628197, "Sudden death ": 4.549799579895668, "Sudden infant death syndrome ": 93.29158502596154, "Thrombocytopenic purpura ": 44.74746314121028, "Unresponsive to stimuli ": 6.618483593562401, "Upper respiratory tract infection ": 4.000349251026849, "Urticaria ": 2.1173654720942245, "Vaccination complication ": 59.395613897084125, "Vaccination site erythema ": 3.684474335846635, "Vaccination site 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2.618855389993735, "Rash maculo-papular ": 8.311663762314943} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/883.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/883.json new file mode 100644 index 00000000000..7e520017f93 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/883.json @@ -0,0 +1 @@ +{"Anxiety ": 2.998800227940469, "Blood pressure increased ": 2.0026373772275017, "Cardiac arrest ": 6.58525693726546, "Chest X-ray abnormal ": 105.50992778025244, "Confusional state ": 4.004864637665608, "Drug withdrawal syndrome ": 24.6190452188728, "Feeling abnormal ": 3.3862928186652064, "Hallucination ": 9.680678579928584, "Loss of consciousness ": 6.701840247718767, "Memory impairment ": 4.426920092772397, "Mental status changes ": 19.506438340585365, "Off label use ": 3.0059477027440256, "Overdose ": 8.329305050587235, "Pain ": 2.6518190039929026, "Respiratory 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b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/885.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 8.015651642333145, "Angioedema ": 6.576439548123348, "Blood pressure increased ": 4.776165062191402, "Hyperkalaemia ": 10.57789017706332, "Hypertension ": 2.591275157070762, "Hyponatraemia ": 6.851189071467454, "Hypotension ": 8.082714785579464, "Lactic acidosis ": 11.059916099594156, "Syncope ": 5.539313156083034, "Therapy non-responder ": 13.038655792751152, "Urinary retention ": 8.228538927804658} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/886.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/886.json new file mode 100644 index 00000000000..61311242112 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/886.json @@ -0,0 +1 @@ +{"Acute kidney injury ": 5.06486137229661, "Hypokalaemia ": 15.130603851658217, "Hyponatraemia ": 43.86941329753903, "Hypotension ": 12.778253573492035, "Orthostatic hypotension ": 80.7792087104857, "Presyncope ": 15.515070674962002, "Syncope ": 5.122572817708822} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/887.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/887.json new file mode 100644 index 00000000000..475059ff9c1 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/887.json @@ -0,0 +1 @@ +{"Acute pulmonary oedema ": 6.1841997790620615, "Allergic transfusion reaction ": 272.9148648519022, "Anaphylactic reaction ": 3.961812408145085, "Anaphylactoid reaction ": 3.1710018807822, "Anti A antibody positive ": 411.1213401477086, "Anti-erythrocyte antibody ": 319.5880767178647, "Anti-erythrocyte antibody positive ": 730.083056576617, "Autoimmune haemolytic anaemia ": 3.6635580061077113, "Back pain ": 2.6356742134845845, "Bacteraemia ": 7.2704653184229, "Blood lactate dehydrogenase increased ": 3.3082874692811566, "Blood pressure decreased ": 2.029604099352155, "Blood pressure increased ": 2.722239161204472, "Body temperature increased ": 3.790242614227624, "Bronchospasm ": 4.148995036433701, "Chills ": 3.014999674561454, "Chromaturia ": 2.622878860751225, "Chronic inflammatory demyelinating polyradiculoneuropathy ": 29.24673654037771, "Coombs direct test positive ": 210.28683316964447, "Cyanosis ": 4.118398060471376, "Delayed haemolytic transfusion reaction ": 495.6868531747263, "Dermatitis allergic ": 3.23224443753568, "Dermatitis exfoliative generalised ": 2.0205750252300785, "Device related infection ": 2.9943085932331317, "Drug ineffective for unapproved indication ": 5.125674555785447, "Dyshidrotic eczema ": 26.660673261154635, "Dyspnoea ": 2.0678915008373484, "Eczema ": 4.765227278160462, "Extravasation ": 12.787199123165037, "Febrile nonhaemolytic transfusion reaction ": 317.7727198394914, "Feeling cold ": 2.475796150970327, "Flank pain ": 3.1278612369409178, "Flushing ": 5.949458327414318, "Gynaecomastia ": 3.709308692450034, "Haemoglobin decreased ": 4.920588638963006, "Haemoglobinuria ": 53.542714015237856, "Haemolysis ": 61.155702214235205, "Haemolytic anaemia ": 31.21080953731264, "Haptoglobin decreased ": 36.938125840309176, "Heart rate increased ": 2.19595753276031, "Hepatitis B ": 10.453215321051678, "Hepatitis B core antibody positive ": 208.86329001087176, "Hepatitis B surface antibody positive ": 195.02144887657207, "Hyper IgE syndrome ": 899.2415428498616, "Hyperpyrexia ": 2.0282736378861026, "Hypersensitivity ": 2.934393403044051, "Hypertension ": 3.20228563213158, "Hyperthermia ": 7.607573797966813, "Hypervolaemia ": 5.634730193326282, "Hypotension ": 2.63594851614826, "Hypothermia ": 2.376735416412435, "Hypoxia ": 7.532469597979104, "Incorrect drug administration rate ": 37.95988970092924, "Infusion related reaction ": 4.275398723087484, "Infusion site erythema ": 7.022568771584545, "Infusion site extravasation ": 13.581766027170556, "Infusion site swelling ": 8.981761725849443, "Intravascular haemolysis ": 39.990700029654185, "Livedo reticularis ": 19.03912835262059, "Lung infiltration ": 2.6600506191558626, "Meningeal disorder ": 51.82943737253477, "Meningism ": 43.225935869015366, "Meningitis ": 6.605751755991852, "Meningitis aseptic ": 180.9170365490505, "Musculoskeletal stiffness ": 3.0584277161268454, "Myasthenia gravis ": 2.5122200044316805, "Neck pain ": 2.193681865750557, "No adverse event ": 43.07986275294141, "Nuchal rigidity ": 22.847411545135053, "Oxygen saturation decreased ": 8.897954141189457, "Pallor ": 2.6533243868124803, "Phonophobia ": 25.714108279276303, "Photophobia ": 9.29597606194154, "Pneumonia staphylococcal ": 23.70586074885136, "Product use in unapproved indication ": 2.2924063894471667, "Pulmonary embolism ": 2.0149134485371296, "Rash pruritic ": 2.1022444291990205, "Recalled product administered ": 29.230659891431067, "Red blood cell 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index 00000000000..27993e8ea74 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/889.json @@ -0,0 +1 @@ +{"Anxiety ": 2.999901777382809, "Arthritis ": 3.1474188356173176, "Autoimmune disorder ": 9.30614159252814, "Back pain ": 2.1297964786699315, "Blood parathyroid hormone increased ": 80.47040917665356, "Blood pressure increased ": 5.105591455729214, "Bone pain ": 2.833537344080409, "Dysuria ": 6.945468874700508, "Fall ": 2.3512809644354324, "Femur fracture ": 15.044543227503732, "Hypocalcaemia ": 44.18413924393011, "Hyponatraemia ": 7.665441288249248, "Impaired healing ": 7.726653681938115, "Jaundice ": 3.6114092421598, "Nervousness ": 4.0959464766758495, "Osteoarthritis ": 5.216499118007124, "Osteonecrosis of jaw ": 24.149922892268723, "Sleep disorder ": 2.791366773875038, "Urinary tract infection ": 2.6287628060295765, "Weight decreased ": 2.3125827648970656} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/89.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/89.json new file mode 100644 index 00000000000..e4c068f027b --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/89.json @@ -0,0 +1 @@ +{"Drug ineffective ": 6.068142641212956} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/890.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/890.json new file mode 100644 index 00000000000..d9ba06e1966 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/890.json @@ -0,0 +1 @@ +{"Abscess ": 5.575513494058053, "Accidental overdose ": 2.432886351274688, "Akathisia ": 6.113084100920687, "Altered state of consciousness ": 3.2260480695283427, "Atrioventricular block ": 5.165848409677793, "Blood pressure systolic decreased ": 13.284823948958318, "Blood 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\ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/893.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/893.json new file mode 100644 index 00000000000..65f3bb5cea8 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/893.json @@ -0,0 +1 @@ +{"Alanine aminotransferase increased ": 3.333100499717094, "Amnesia ": 5.049670818159369, "Angioedema ": 2.879188159190186, "Aspartate aminotransferase increased ": 2.3873011206980417, "Blood alkaline phosphatase increased ": 5.092025947720859, "Blood creatine phosphokinase increased ": 3.1172410031194104, "Blood lactate dehydrogenase increased ": 4.881780841508879, "Blood pressure increased ": 2.3575046156835926, "Bone pain ": 2.520865924539914, "C-reactive protein increased ": 6.220816402775791, "Deep vein thrombosis ": 18.976521298233443, "Dermatitis bullous ": 7.295777580713275, "Disorientation ": 2.5225128899865514, "Drug 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a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/9.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/9.json new file mode 100644 index 00000000000..973f1196589 --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/9.json @@ -0,0 +1 @@ +{"Emotional distress ": 161.85208465362794, "Hypersensitivity ": 70.04082379006084, "Injury ": 405.3413816831731} \ No newline at end of file diff --git a/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/90.json b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/90.json new file mode 100644 index 00000000000..d04d1f1e71e --- /dev/null +++ b/docs/SymptomsCausedByDrugs/data/ProportionalReportingRatios/vaccines/90.json @@ -0,0 +1 @@ +{"Cardio-respiratory arrest ": 28.557408124964653, "Completed suicide ": 24.51375262499884, "Overdose ": 9.465665925996325} \ No newline at end of file diff --git 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